
                                SEQUENCE LISTING

<110> Halozyme Inc.
      Gilbert Keller
      Gregory Frost

<120> In Vivo Temporal Control of Activatable
  Matrix-Degrading Enzymes
  

<130> 0119374-00101/ 3056PC

<140> Not yet assigned
<141> Herewith

<150> US 61/127,725
<151> 2008-05-14

<150> US 61/068,667
<151> 2008-03-06

<160> 537

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 220
<212> PRT
<213> Homo sapiens

<220> 
<223> Cathepsin L mature

<220> 
<223> cathepsin L1 heavy chain 1-175

<220> 
<223> cathepsin L1 light chain 179-220

<400> 1
Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro Val
 1               5                  10                  15      
Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr Gly
            20                  25                  30          
Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser Leu
        35                  40                  45              
Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu Gly
    50                  55                  60                  
Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp Asn
65                  70                  75                  80  
Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu Glu
                85                  90                  95      
Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly Phe
            100                 105                 110         
Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala Thr
        115                 120                 125             
Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe Leu
    130                 135                 140                 
Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu Asp
145                 150                 155                 160 
Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr Glu
                165                 170                 175     
Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu Glu
            180                 185                 190         
Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn His
        195                 200                 205             
Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val
    210                 215                 220 


<210> 2
<211> 22
<212> PRT
<213> Homo sapiens

<220> 
<223>  kappa IgG heterologous signal sequence

<400> 2
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp
 1               5                  10                  15      
Leu Pro Gly Ala Arg Gly
            20          


<210> 3
<211> 1032
<212> DNA
<213> Homo sapiens

<220> 
<223> Optimized synthetic Cat-L construct with
      heterologous signal sequence and Nhe1 and BamHI
      restriction sites

<400> 3
gctagcatgg acatgcgcgt acctgctcag ttgttggggc tcttgctgct gtggttgccc 60
ggggcacgtg ggactctgac cttcgaccat tcactggagg cccagtggac taagtggaag 120
gctatgcata atcgacttta cggcatgaac gaggagggtt ggcggcgggc tgtgtgggag 180
aagaatatga aaatgatcga actgcataac caggaataca gagagggcaa gcacagtttt 240
accatggcaa tgaatgcatt tggggacatg actagcgagg aatttcggca agtgatgaat 300
ggtttccaga atcgcaagcc aagaaaaggg aaggtcttcc aggagcccct cttctacgag 360
gcccctcgta gtgtcgactg gcgggagaaa ggctacgtga caccagtcaa aaaccagggc 420
caatgcggct cctgctgggc attttctgcc accggtgctc tggaaggaca aatgttcagg 480
aagactggcc gtctcatctc cttgtccgaa cagaacctgg tggactgctc cgggccacag 540
gggaatgagg ggtgcaacgg ggggcttatg gactacgcct tccagtacgt gcaggataat 600
gggggtctcg attccgagga atcctacccc tacgaagcaa ctgaggaatc ttgcaagtat 660
aaccctaagt attccgtggc aaatgatact ggcttcgtgg atatccctaa acaggaaaag 720
gccctcatga aggccgtagc caccgtgggc cccatctctg tcgcaattga cgctggtcac 780
gagtctttcc tcttctataa ggaaggtata tactttgaac ccgattgcag cagtgaggac 840
atggatcatg gcgtactcgt cgtcgggtat ggttttgaga gtaccgaatc agataataat 900
aaatattggc tggtgaaaaa cagctggggt gaggagtggg gtatgggtgg ctacgtcaag 960
atggccaagg accgtaggaa ccattgtggt atcgcatctg ctgcatctta tcccactgtg 1020
taatagggat cc                                                     1032

<210> 4
<211> 338
<212> PRT
<213> Homo sapiens

<220> 
<223> Optimized synthetic Cat-L construct with
      heterologous signal sequence
      

<400> 4
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp
 1               5                  10                  15      
Leu Pro Gly Ala Arg Gly Thr Leu Thr Phe Asp His Ser Leu Glu Ala
            20                  25                  30          
Gln Trp Thr Lys Trp Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn
        35                  40                  45              

Glu Glu Gly Trp Arg Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile
    50                  55                  60                  
Glu Leu His Asn Gln Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met
65                  70                  75                  80  
Ala Met Asn Ala Phe Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val
                85                  90                  95      
Met Asn Gly Phe Gln Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln
            100                 105                 110         
Glu Pro Leu Phe Tyr Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys
        115                 120                 125             
Gly Tyr Val Thr Pro Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp
    130                 135                 140                 
Ala Phe Ser Ala Thr Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr
145                 150                 155                 160 
Gly Arg Leu Ile Ser Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly
                165                 170                 175     
Pro Gln Gly Asn Glu Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe
            180                 185                 190         
Gln Tyr Val Gln Asp Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro
        195                 200                 205             
Tyr Glu Ala Thr Glu Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val
    210                 215                 220                 
Ala Asn Asp Thr Gly Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu
225                 230                 235                 240 
Met Lys Ala Val Ala Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala
                245                 250                 255     
Gly His Glu Ser Phe Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro
            260                 265                 270         
Asp Cys Ser Ser Glu Asp Met Asp His Gly Val Leu Val Val Gly Tyr
        275                 280                 285             
Gly Phe Glu Ser Thr Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys
    290                 295                 300                 
Asn Ser Trp Gly Glu Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala
305                 310                 315                 320 
Lys Asp Arg Arg Asn His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro
                325                 330                 335     
Thr Val
        


<210> 5
<211> 6201
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic Cat-L HZ24 expression vector with
      heterologous signal sequence
      
      

<400> 5
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta 60
ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc 120
aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg 180
gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc 240
gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat 300
agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc 360
ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga 420
cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg 480
gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac 540
caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt 600
caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc 660
cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc 720
tcgtttagtg aaccgtcaga tcactagaag ctttattgcg gtagtttatc acagttaaat 780
tgctaacgca gtcagtgctt ctgacacaac agtctcgaac ttaagctgca gaagttggtc 840
gtgaggcact gggcaggtaa gtatcaaggt tacaagacag gtttaaggag accaatagaa 900
actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta ttggtcttac 960
tgacatccac tttgcctttc tctccacagg tgtccactcc cagttcaatt acagctctta 1020
aggctagagt acttaatacg actcactata ggctagcatg gacatgcgcg tacctgctca 1080
gttgttgggg ctcttgctgc tgtggttgcc cggggcacgt gggactctga ccttcgacca 1140
ttcactggag gcccagtgga ctaagtggaa ggctatgcat aatcgacttt acggcatgaa 1200
cgaggagggt tggcggcggg ctgtgtggga gaagaatatg aaaatgatcg aactgcataa 1260
ccaggaatac agagagggca agcacagttt taccatggca atgaatgcat ttggggacat 1320
gactagcgag gaatttcggc aagtgatgaa tggtttccag aatcgcaagc caagaaaagg 1380
gaaggtcttc caggagcccc tcttctacga ggcccctcgt agtgtcgact ggcgggagaa 1440
aggctacgtg acaccagtca aaaaccaggg ccaatgcggc tcctgctggg cattttctgc 1500
caccggtgct ctggaaggac aaatgttcag gaagactggc cgtctcatct ccttgtccga 1560
acagaacctg gtggactgct ccgggccaca ggggaatgag gggtgcaacg gggggcttat 1620
ggactacgcc ttccagtacg tgcaggataa tgggggtctc gattccgagg aatcctaccc 1680
ctacgaagca actgaggaat cttgcaagta taaccctaag tattccgtgg caaatgatac 1740
tggcttcgtg gatatcccta aacaggaaaa ggccctcatg aaggccgtag ccaccgtggg 1800
ccccatctct gtcgcaattg acgctggtca cgagtctttc ctcttctata aggaaggtat 1860
atactttgaa cccgattgca gcagtgagga catggatcat ggcgtactcg tcgtcgggta 1920
tggttttgag agtaccgaat cagataataa taaatattgg ctggtgaaaa acagctgggg 1980
tgaggagtgg ggtatgggtg gctacgtcaa gatggccaag gaccgtagga accattgtgg 2040
tatcgcatct gctgcatctt atcccactgt gtaataggga tccatagcta acgcccctct 2100
ccctcccccc cccctaacgt tactggccga agccgcttgg aataaggccg gtgtgcgttt 2160
gtctatatgt tattttccac catattgccg tcttttggca atgtgagggc ccggaaacct 2220
ggccctgtct tcttgacgag cattcctagg ggtctttccc ctctcgccaa aggaatgcaa 2280
ggtctgttga atgtcgtgaa ggaagcagtt cctctggaag cttcttgaag acaaacaacg 2340
tctgtagcga ccctttgcag gcagcggaac cccccacctg gcgacaggtg cctctgcggc 2400
caaaagccac gtgtataaga tacacctgca aaggcggcac aaccccagtg ccacgttgtg 2460
agttggatag ttgtggaaag agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg 2520
aaggatgccc agaaggtacc ccattgtatg ggatctgatc tggggcctcg gtgcacatgc 2580
tttacatgtg tttagtcgag gttaaaaaaa cgtctaggcc ccccgaacca cggggacgtg 2640
gttttccttt gaaaaacacg atgataagct tgccacaacc cacagcggcc gctgccatca 2700
tggttcgacc attgaactgc atcgtcgccg tgtcccaaaa tatggggatt ggcaagaacg 2760
gagacctacc ctggcctccg ctcaggaacg agttcaagta cttccaaaga atgaccacaa 2820
cctcttcagt ggaaggtaaa cagaatctgg tgattatggg taggaaaacc tggttctcca 2880
ttcctgagaa gaatcgacct ttaaaggaca gaattaatat agttctcagt agagaactca 2940
aagaaccacc acgaggagct cattttcttg ccaaaagttt ggatgatgcc ttaagactta 3000
ttgaacaacc ggaattggca agtaaagtag acatggtttg gatagtcgga ggcagttctg 3060
tttaccagga agccatgaat caaccaggcc acctcagact ctttgtgaca aggatcatgc 3120
aggaatttga aagtgacacg tttttcccag aaattgattt ggggaaatat aaacttctcc 3180
cagaataccc aggcgtcctc tctgaggtcc aggaggaaaa aggcatcaag tataagtttg 3240
aagtctacga gaagaaagac taaacgcgtg gtacctctag agtcgacctg ggcggccgct 3300
tcgagcagac atgataagat acattgatga gtttggacaa accacaacta gaatgcagtg 3360
aaaaaaatgc tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag 3420
ctgcaataaa caagttaaca acaacaattg cattcatttt atgtttcagg ttcaggggga 3480
gatgtgggag gttttttaaa gcaagtaaaa cctctacaaa tgtggtaaaa tcgataagta 3540
tccgggctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac agttgcgcag 3600
cctgaatggc gaatggacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt 3660
acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc 3720
ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct 3780
ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat 3840
ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc 3900
acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc 3960
tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg 4020
atttaacaaa aatttaacgc gaattttaac aaaatattaa cgcttacaat ttcctgatgc 4080
ggtattttct ccttacgcat ctgtgcggta tttcacaccg catatggtgc actctcagta 4140
caatctgctc tgatgccgca tagttaagcc agccccgaca cccgccaaca cccgctgacg 4200
cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg accgtctccg 4260
ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc 4320
tcgtgatacg cctattttta taggttaatg tcatgataat aatggtttct tagacgtcag 4380
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 4440
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 4500
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 4560
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 4620
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 4680
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 4740
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 4800
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 4860
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 4920
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 4980
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 5040
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 5100
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 5160
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 5220
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 5280
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 5340
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 5400
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 5460
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 5520
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 5580
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 5640
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgttctt ctagtgtagc 5700
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 5760
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 5820
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 5880
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 5940
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 6000
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 6060
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 6120
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 6180
ctcacatggc tcgacagatc t                                           6201



<210> 6
<211> 1068
<212> DNA
<213> Homo sapiens

<220> 
<223> Optimized synthetic Cat-L His construct with
      heterologous signal sequence and restriction sites
      

<400> 6
gctagcatgg acatgcgtgt acctgctcag ctgctgggcc tgttgctctt gtggcttccc 60
ggagcccggg gaaccctgac attcgatcac tctctggagg cccagtggac aaaatggaag 120
gctatgcaca ataggctcta cgggatgaat gaggaaggct ggagaagggc cgtttgggag 180
aagaatatga aaatgattga gctgcacaac caggagtacc gagagggaaa gcattccttt 240
accatggcaa tgaatgcctt tggggacatg acatcagagg agtttcggca ggtgatgaac 300
ggatttcaga atagaaagcc ccgaaaaggc aaagtgttcc aagagcccct cttttacgag 360
gccccacgct ccgtcgactg gcgtgaaaaa gggtatgtaa ctcccgtcaa aaaccaggga 420
cagtgcggca gttgttgggc cttttctgct accggggcat tggagggcca gatgttcagg 480
aagaccggac gtcttatctc cctttcagaa cagaacctgg tcgactgtag cggaccccag 540
ggaaacgagg ggtgcaatgg agggctcatg gactatgcat ttcagtacgt gcaggacaat 600
ggaggcctgg attcagagga atcctaccct tacgaggcta cagaagaaag ctgcaagtat 660
aaccctaagt acagcgtcgc caacgacacc gggtttgtcg atattccaaa gcaggagaag 720
gccctgatga aagcagttgc caccgtgggc cccatctcag tcgcaattga tgccggccac 780
gagtcttttc tgttttataa agaaggtatt tactttgagc ccgattgcag ctctgaagac 840
atggatcacg gagtgttggt tgtaggctac ggcttcgagt ccaccgagtc agacaacaat 900
aaatactggt tggtgaaaaa ctcctggggg gaggagtggg gcatgggcgg atacgtgaag 960
atggccaaag acagaaggaa tcactgtgga atcgcatctg ctgccagcta tccaactgta 1020
ggaggaggcg gttcaggtca ccaccaccat caccactagt gaggatcc              1068

<210> 7

<211> 350
<212> PRT
<213> Homo sapiens

<220> 
<223> Optimized synthetic Cat-L-His construct with
      heterologous signal sequence
      

<400> 7
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp
 1               5                  10                  15      
Leu Pro Gly Ala Arg Gly Thr Leu Thr Phe Asp His Ser Leu Glu Ala
            20                  25                  30          
Gln Trp Thr Lys Trp Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn
        35                  40                  45              
Glu Glu Gly Trp Arg Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile
    50                  55                  60                  
Glu Leu His Asn Gln Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met
65                  70                  75                  80  
Ala Met Asn Ala Phe Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val
                85                  90                  95      
Met Asn Gly Phe Gln Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln
            100                 105                 110         
Glu Pro Leu Phe Tyr Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys
        115                 120                 125             
Gly Tyr Val Thr Pro Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp
    130                 135                 140                 
Ala Phe Ser Ala Thr Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr
145                 150                 155                 160 
Gly Arg Leu Ile Ser Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly
                165                 170                 175     
Pro Gln Gly Asn Glu Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe
            180                 185                 190         
Gln Tyr Val Gln Asp Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro
        195                 200                 205             
Tyr Glu Ala Thr Glu Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val
    210                 215                 220                 
Ala Asn Asp Thr Gly Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu
225                 230                 235                 240 
Met Lys Ala Val Ala Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala
                245                 250                 255     
Gly His Glu Ser Phe Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro
            260                 265                 270         
Asp Cys Ser Ser Glu Asp Met Asp His Gly Val Leu Val Val Gly Tyr
        275                 280                 285             
Gly Phe Glu Ser Thr Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys
    290                 295                 300                 
Asn Ser Trp Gly Glu Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala
305                 310                 315                 320 
Lys Asp Arg Arg Asn His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro
                325                 330                 335     
Thr Val Gly Gly Gly Gly Ser Gly His His His His His His
            340                 345                 350 


<210> 8
<211> 6237
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Cat-L-His expression vector with
      heterologous signal sequence
      
      

<400> 8
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta 60
ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc 120
aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg 180
gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc 240
gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat 300
agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc 360
ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga 420
cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg 480
gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac 540
caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt 600
caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc 660
cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc 720
tcgtttagtg aaccgtcaga tcactagaag ctttattgcg gtagtttatc acagttaaat 780
tgctaacgca gtcagtgctt ctgacacaac agtctcgaac ttaagctgca gaagttggtc 840
gtgaggcact gggcaggtaa gtatcaaggt tacaagacag gtttaaggag accaatagaa 900
actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta ttggtcttac 960
tgacatccac tttgcctttc tctccacagg tgtccactcc cagttcaatt acagctctta 1020
aggctagagt acttaatacg actcactata ggctagcatg gacatgcgtg tacctgctca 1080
gctgctgggc ctgttgctct tgtggcttcc cggagcccgg ggaaccctga cattcgatca 1140
ctctctggag gcccagtgga caaaatggaa ggctatgcac aataggctct acgggatgaa 1200
tgaggaaggc tggagaaggg ccgtttggga gaagaatatg aaaatgattg agctgcacaa 1260
ccaggagtac cgagagggaa agcattcctt taccatggca atgaatgcct ttggggacat 1320
gacatcagag gagtttcggc aggtgatgaa cggatttcag aatagaaagc cccgaaaagg 1380
caaagtgttc caagagcccc tcttttacga ggccccacgc tccgtcgact ggcgtgaaaa 1440
agggtatgta actcccgtca aaaaccaggg acagtgcggc agttgttggg ccttttctgc 1500
taccggggca ttggagggcc agatgttcag gaagaccgga cgtcttatct ccctttcaga 1560
acagaacctg gtcgactgta gcggacccca gggaaacgag gggtgcaatg gagggctcat 1620
ggactatgca tttcagtacg tgcaggacaa tggaggcctg gattcagagg aatcctaccc 1680
ttacgaggct acagaagaaa gctgcaagta taaccctaag tacagcgtcg ccaacgacac 1740
cgggtttgtc gatattccaa agcaggagaa ggccctgatg aaagcagttg ccaccgtggg 1800
ccccatctca gtcgcaattg atgccggcca cgagtctttt ctgttttata aagaaggtat 1860
ttactttgag cccgattgca gctctgaaga catggatcac ggagtgttgg ttgtaggcta 1920
cggcttcgag tccaccgagt cagacaacaa taaatactgg ttggtgaaaa actcctgggg 1980
ggaggagtgg ggcatgggcg gatacgtgaa gatggccaaa gacagaagga atcactgtgg 2040
aatcgcatct gctgccagct atccaactgt aggaggaggc ggttcaggtc accaccacca 2100
tcaccactag tgaggatcca tagctaacgc ccctctccct cccccccccc taacgttact 2160
ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt ttccaccata 2220
ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt gacgagcatt 2280
cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt cgtgaaggaa 2340
gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct ttgcaggcag 2400
cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt ataagataca 2460
cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt ggaaagagtc 2520
aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa ggtaccccat 2580
tgtatgggat ctgatctggg gcctcggtgc acatgcttta catgtgttta gtcgaggtta 2640
aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa aacacgatga 2700
taagcttgcc acaacccaca gcggccgctg ccatcatggt tcgaccattg aactgcatcg 2760
tcgccgtgtc ccaaaatatg gggattggca agaacggaga cctaccctgg cctccgctca 2820
ggaacgagtt caagtacttc caaagaatga ccacaacctc ttcagtggaa ggtaaacaga 2880
atctggtgat tatgggtagg aaaacctggt tctccattcc tgagaagaat cgacctttaa 2940
aggacagaat taatatagtt ctcagtagag aactcaaaga accaccacga ggagctcatt 3000
ttcttgccaa aagtttggat gatgccttaa gacttattga acaaccggaa ttggcaagta 3060
aagtagacat ggtttggata gtcggaggca gttctgttta ccaggaagcc atgaatcaac 3120
caggccacct cagactcttt gtgacaagga tcatgcagga atttgaaagt gacacgtttt 3180
tcccagaaat tgatttgggg aaatataaac ttctcccaga atacccaggc gtcctctctg 3240
aggtccagga ggaaaaaggc atcaagtata agtttgaagt ctacgagaag aaagactaaa 3300
cgcgtggtac ctctagagtc gacctgggcg gccgcttcga gcagacatga taagatacat 3360
tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat 3420
ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa 3480
caattgcatt cattttatgt ttcaggttca gggggagatg tgggaggttt tttaaagcaa 3540
gtaaaacctc tacaaatgtg gtaaaatcga taagtatccg ggctggcgta atagcgaaga 3600
ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat ggacgcgccc 3660
tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt 3720
gccagcgccc tagcgcccgc tcctttcgct ttcttccctt cctttctcgc cacgttcgcc 3780
ggctttcccc gtcaagctct aaatcggggg ctccctttag ggttccgatt tagtgcttta 3840
cggcacctcg accccaaaaa acttgattag ggtgatggtt cacgtagtgg gccatcgccc 3900
tgatagacgg tttttcgccc tttgacgttg gagtccacgt tctttaatag tggactcttg 3960
ttccaaactg gaacaacact caaccctatc tcggtctatt cttttgattt ataagggatt 4020
ttgccgattt cggcctattg gttaaaaaat gagctgattt aacaaaaatt taacgcgaat 4080
tttaacaaaa tattaacgct tacaatttcc tgatgcggta ttttctcctt acgcatctgt 4140
gcggtatttc acaccgcata tggtgcactc tcagtacaat ctgctctgat gccgcatagt 4200
taagccagcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc 4260
cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt 4320
caccgtcatc accgaaacgc gcgagacgaa agggcctcgt gatacgccta tttttatagg 4380
ttaatgtcat gataataatg gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc 4440
gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac 4500
aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt 4560
tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag 4620
aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg 4680
aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa 4740
tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc 4800
aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag 4860
tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa 4920
ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc 4980
taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg 5040
agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa 5100
caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa 5160
tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg 5220
gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag 5280
cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg 5340
caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt 5400
ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt 5460
aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac 5520
gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag 5580
atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg 5640
tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca 5700
gagcgcagat accaaatact gttcttctag tgtagccgta gttaggccac cacttcaaga 5760
actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca 5820
gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc 5880
agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca 5940
ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa 6000
aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc 6060
cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc 6120
gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg 6180
cctttttacg gttcctggcc ttttgctggc cttttgctca catggctcga cagatct    6237



<210> 9
<211> 333
<212> PRT
<213> Homo sapiens

<220> 
<223> Human Cat-L protein containing heterologous
      secretory signal
      

<400> 9
Met Asp Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser
 1               5                  10                  15      
Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp
            20                  25                  30          
Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg
        35                  40                  45              
Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln
    50                  55                  60                  
Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe
65                  70                  75                  80  
Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln
                85                  90                  95      
Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr
            100                 105                 110         
Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro
        115                 120                 125             
Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr
    130                 135                 140                 
Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser
145                 150                 155                 160 
Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu
                165                 170                 175     
Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp
            180                 185                 190         
Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu
        195                 200                 205             

Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly
    210                 215                 220                 
Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala
225                 230                 235                 240 
Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe
                245                 250                 255     
Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu
            260                 265                 270         
Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr
        275                 280                 285             
Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu
    290                 295                 300                 
Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn
305                 310                 315                 320 
His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val
                325                 330             



<210> 10
<211> 1002
<212> DNA
<213> Homo sapiens

<220> 
<223> Sequenced cDNA of Cat-L insert (BATJ)

<400> 10
atggatccta cactcatcct tgctgccttt tgcctgggaa ttgcctcagc tactctaaca 60
tttgatcaca gtttagaggc acagtggacc aagtggaagg cgatgcacaa cagattatac 120
ggcatgaatg aagaaggatg gaggagagca gtgtgggaga agaacatgaa gatgattgaa 180
ctgcacaatc aggaatacag ggaagggaaa cacagcttca caatggccat gaacgccttt 240
ggagacatga ccagtgaaga attcaggcag gtgatgaatg gctttcaaaa ccgtaagccc 300
aggaagggga aagtgttcca ggaacctctg ttttatgagg cccccagatc tgtggattgg 360
agagagaaag gctacgtgac tcctgtgaag aatcagggtc agtgtggttc ttgttgggct 420
tttagtgcta ctggtgctct tgaaggacag atgttccgga aaactgggag gcttatctca 480
ctgagtgagc agaatctggt agactgctct gggcctcaag gcaatgaagg ctgcaatggt 540
ggcctaatgg attatgcttt ccagtatgtt caggataatg gaggcctgga ctctgaggaa 600
tcctatccat atgaggcaac agaagaatcc tgtaagtaca atcccaagta ttctgttgct 660
aatgacaccg gctttgtgga catccctaag caggagaagg ccctgatgaa ggcagttgca 720
actgtggggc ccatttctgt tgctattgat gcaggtcatg agtccttcct gttctataaa 780
gaaggcattt attttgagcc agactgtagc agtgaagaca tggatcatgg tgtgctggtg 840
gttggctacg gatttgaaag cacagaatca gataacaata aatattggct ggtgaagaac 900
agctggggtg aagaatgggg catgggtggc tacgtaaaga tggccaaaga ccggagaaac 960
cattgtggaa ttgcctcagc agccagctac cccactgtgt ga                    1002

<210> 11
<211> 6190
<212> DNA
<213> Artificial Sequence

<220> 
<223> HZ24 expression vector containin Cat-L cDNA
      
      

<400> 11
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta 60
ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc 120
aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg 180
gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc 240
gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat 300
agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc 360
ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga 420
cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg 480
gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac 540
caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt 600
caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc 660
cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc 720
tcgtttagtg aaccgtcaga tcactagaag ctttattgcg gtagtttatc acagttaaat 780
tgctaacgca gtcagtgctt ctgacacaac agtctcgaac ttaagctgca gaagttggtc 840
gtgaggcact gggcaggtaa gtatcaaggt tacaagacag gtttaaggag accaatagaa 900
actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta ttggtcttac 960
tgacatccac tttgcctttc tctccacagg tgtccactcc cagttcaatt acagctctta 1020
aggctagagt acttaatacg actcactata ggctagccac catggatcct acactcatcc 1080
ttgctgcctt ttgcctggga attgcctcag ctactctaac atttgatcac agtttagagg 1140
cacagtggac caagtggaag gcgatgcaca acagattata cggcatgaat gaagaaggat 1200
ggaggagagc agtgtgggag aagaacatga agatgattga actgcacaat caggaataca 1260
gggaagggaa acacagcttc acaatggcca tgaacgcctt tggagacatg accagtgaag 1320
aattcaggca ggtgatgaat ggctttcaaa accgtaagcc caggaagggg aaagtgttcc 1380
aggaacctct gttttatgag gcccccagat ctgtggattg gagagagaaa ggctacgtga 1440
ctcctgtgaa gaatcagggt cagtgtggtt cttgttgggc ttttagtgct actggtgctc 1500
ttgaaggaca gatgttccgg aaaactggga ggcttatctc actgagtgag cagaatctgg 1560
tagactgctc tgggcctcaa ggcaatgaag gctgcaatgg tggcctaatg gattatgctt 1620
tccagtatgt tcaggataat ggaggcctgg actctgagga atcctatcca tatgaggcaa 1680
cagaagaatc ctgtaagtac aatcccaagt attctgttgc taatgacacc ggctttgtgg 1740
acatccctaa gcaggagaag gccctgatga aggcagttgc aactgtgggg cccatttctg 1800
ttgctattga tgcaggtcat gagtccttcc tgttctataa agaaggcatt tattttgagc 1860
cagactgtag cagtgaagac atggatcatg gtgtgctggt ggttggctac ggatttgaaa 1920
gcacagaatc agataacaat aaatattggc tggtgaagaa cagctggggt gaagaatggg 1980
gcatgggtgg ctacgtaaag atggccaaag accggagaaa ccattgtgga attgcctcag 2040
cagccagcta ccccactgtg tgatgaggat ccatagctaa cgcccctctc cctccccccc 2100
ccctaacgtt actggccgaa gccgcttgga ataaggccgg tgtgcgtttg tctatatgtt 2160
attttccacc atattgccgt cttttggcaa tgtgagggcc cggaaacctg gccctgtctt 2220
cttgacgagc attcctaggg gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa 2280
tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac 2340
cctttgcagg cagcggaacc ccccacctgg cgacaggtgc ctctgcggcc aaaagccacg 2400
tgtataagat acacctgcaa aggcggcaca accccagtgc cacgttgtga gttggatagt 2460
tgtggaaaga gtcaaatggc tctcctcaag cgtattcaac aaggggctga aggatgccca 2520
gaaggtaccc cattgtatgg gatctgatct ggggcctcgg tgcacatgct ttacatgtgt 2580
ttagtcgagg ttaaaaaaac gtctaggccc cccgaaccac ggggacgtgg ttttcctttg 2640
aaaaacacga tgataagctt gccacaaccc acagcggccg ctgccatcat ggttcgacca 2700
ttgaactgca tcgtcgccgt gtcccaaaat atggggattg gcaagaacgg agacctaccc 2760
tggcctccgc tcaggaacga gttcaagtac ttccaaagaa tgaccacaac ctcttcagtg 2820
gaaggtaaac agaatctggt gattatgggt aggaaaacct ggttctccat tcctgagaag 2880
aatcgacctt taaaggacag aattaatata gttctcagta gagaactcaa agaaccacca 2940
cgaggagctc attttcttgc caaaagtttg gatgatgcct taagacttat tgaacaaccg 3000
gaattggcaa gtaaagtaga catggtttgg atagtcggag gcagttctgt ttaccaggaa 3060
gccatgaatc aaccaggcca cctcagactc tttgtgacaa ggatcatgca ggaatttgaa 3120
agtgacacgt ttttcccaga aattgatttg gggaaatata aacttctccc agaataccca 3180
ggcgtcctct ctgaggtcca ggaggaaaaa ggcatcaagt ataagtttga agtctacgag 3240
aagaaagact aaacgcgtgg tacctctaga gtcgacctgg gcggccgctt cgagcagaca 3300
tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct 3360
ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac 3420
aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag atgtgggagg 3480
ttttttaaag caagtaaaac ctctacaaat gtggtaaaat cgataagtat ccgggctggc 3540
gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg 3600
aatggacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt 3660
gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct 3720
cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg 3780
atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag 3840
tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa 3900
tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga 3960
tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa 4020
atttaacgcg aattttaaca aaatattaac gcttacaatt tcctgatgcg gtattttctc 4080
cttacgcatc tgtgcggtat ttcacaccgc atatggtgca ctctcagtac aatctgctct 4140
gatgccgcat agttaagcca gccccgacac ccgccaacac ccgctgacgc gccctgacgg 4200
gcttgtctgc tcccggcatc cgcttacaga caagctgtga ccgtctccgg gagctgcatg 4260
tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac gaaagggcct cgtgatacgc 4320
ctatttttat aggttaatgt catgataata atggtttctt agacgtcagg tggcactttt 4380
cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat 4440
ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg 4500
agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg ccttcctgtt 4560
tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt gggtgcacga 4620
gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa 4680
gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt attatcccgt 4740
attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa tgacttggtt 4800
gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag agaattatgc 4860
agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac aacgatcgga 4920
ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac tcgccttgat 4980
cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac cacgatgcct 5040
gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac tctagcttcc 5100
cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact tctgcgctcg 5160
gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg tgggtctcgc 5220
ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt tatctacacg 5280
acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat aggtgcctca 5340
ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta gattgattta 5400
aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc 5460
aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa 5520
ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca 5580
ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta 5640
actggcttca gcagagcgca gataccaaat actgttcttc tagtgtagcc gtagttaggc 5700
caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca 5760
gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta 5820
ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag 5880
cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt 5940
cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc 6000
acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac 6060
ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac 6120
gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatggct 6180
cgacagatct                                                        6190



<210> 12
<211> 339
<212> PRT
<213> Homo sapiens

<220> 
<223> Human-Cat-L-His containing heterologous secretory
      signal
      

<400> 12
Met Asp Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser
 1               5                  10                  15      
Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp
            20                  25                  30          
Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg
        35                  40                  45              
Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln
    50                  55                  60                  
Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe
65                  70                  75                  80  
Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln
                85                  90                  95      
Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr
            100                 105                 110         
Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro
        115                 120                 125             
Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr
    130                 135                 140                 
Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser
145                 150                 155                 160 
Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu
                165                 170                 175     
Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp
            180                 185                 190         
Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu
        195                 200                 205             
Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly
    210                 215                 220                 
Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala
225                 230                 235                 240 
Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe
                245                 250                 255     
Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu
            260                 265                 270         
Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr
        275                 280                 285             
Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu
    290                 295                 300                 
Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn
305                 310                 315                 320 
His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val His His His
                325                 330                 335     
His His His
            


<210> 13
<211> 1020
<212> DNA
<213> Homo sapiens

<220> 
<223> Encoding human cat-L-His
      

<400> 13
atggatccta cactcatcct tgctgccttt tgcctgggaa ttgcctcagc tactctaaca 60
tttgatcaca gtttagaggc acagtggacc aagtggaagg cgatgcacaa cagattatac 120
ggcatgaatg aagaaggatg gaggagagca gtgtgggaga agaacatgaa gatgattgaa 180
ctgcacaatc aggaatacag ggaagggaaa cacagcttca caatggccat gaacgccttt 240
ggagacatga ccagtgaaga attcaggcag gtgatgaatg gctttcaaaa ccgtaagccc 300
aggaagggga aagtgttcca ggaacctctg ttttatgagg cccccagatc tgtggattgg 360
agagagaaag gctacgtgac tcctgtgaag aatcagggtc agtgtggttc ttgttgggct 420
tttagtgcta ctggtgctct tgaaggacag atgttccgga aaactgggag gcttatctca 480
ctgagtgagc agaatctggt agactgctct gggcctcaag gcaatgaagg ctgcaatggt 540
ggcctaatgg attatgcttt ccagtatgtt caggataatg gaggcctgga ctctgaggaa 600
tcctatccat atgaggcaac agaagaatcc tgtaagtaca atcccaagta ttctgttgct 660
aatgacaccg gctttgtgga catccctaag caggagaagg ccctgatgaa ggcagttgca 720
actgtggggc ccatttctgt tgctattgat gcaggtcatg agtccttcct gttctataaa 780
gaaggcattt attttgagcc agactgtagc agtgaagaca tggatcatgg tgtgctggtg 840
gttggctacg gatttgaaag cacagaatca gataacaata aatattggct ggtgaagaac 900
agctggggtg aagaatgggg catgggtggc tacgtaaaga tggccaaaga ccggagaaac 960
cattgtggaa ttgcctcagc agccagctac cccactgtgc atcatcatca tcatcattga 1020


<210> 14
<211> 6205
<212> DNA
<213> Artificial Sequence

<220> 
<223> HZ24 expression vector contain Cat-L-His cDNA
      
      
      

<400> 14
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta 60
ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc 120
aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg 180
gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc 240
gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat 300
agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc 360
ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga 420
cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg 480
gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac 540
caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt 600
caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc 660
cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc 720
tcgtttagtg aaccgtcaga tcactagaag ctttattgcg gtagtttatc acagttaaat 780
tgctaacgca gtcagtgctt ctgacacaac agtctcgaac ttaagctgca gaagttggtc 840
gtgaggcact gggcaggtaa gtatcaaggt tacaagacag gtttaaggag accaatagaa 900
actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta ttggtcttac 960
tgacatccac tttgcctttc tctccacagg tgtccactcc cagttcaatt acagctctta 1020
aggctagagt acttaatacg actcactata ggctagccac catggatcct acactcatcc 1080
ttgctgcctt ttgcctggga attgcctcag ctactctaac atttgatcac agtttagagg 1140
cacagtggac caagtggaag gcgatgcaca acagattata cggcatgaat gaagaaggat 1200
ggaggagagc agtgtgggag aagaacatga agatgattga actgcacaat caggaataca 1260
gggaagggaa acacagcttc acaatggcca tgaacgcctt tggagacatg accagtgaag 1320
aattcaggca ggtgatgaat ggctttcaaa accgtaagcc caggaagggg aaagtgttcc 1380
aggaacctct gttttatgag gcccccagat ctgtggattg gagagagaaa ggctacgtga 1440
ctcctgtgaa gaatcagggt cagtgtggtt cttgttgggc ttttagtgct actggtgctc 1500
ttgaaggaca gatgttccgg aaaactggga ggcttatctc actgagtgag cagaatctgg 1560
tagactgctc tgggcctcaa ggcaatgaag gctgcaatgg tggcctaatg gattatgctt 1620
tccagtatgt tcaggataat ggaggcctgg actctgagga atcctatcca tatgaggcaa 1680
cagaagaatc ctgtaagtac aatcccaagt attctgttgc taatgacacc ggctttgtgg 1740
acatccctaa gcaggagaag gccctgatga aggcagttgc aactgtgggg cccatttctg 1800
ttgctattga tgcaggtcat gagtccttcc tgttctataa agaaggcatt tattttgagc 1860
cagactgtag cagtgaagac atggatcatg gtgtgctggt ggttggctac ggatttgaaa 1920
gcacagaatc agataacaat aaatattggc tggtgaagaa cagctggggt gaagaatggg 1980
gcatgggtgg ctacgtaaag atggccaaag accggagaaa ccattgtgga attgcctcag 2040
cagccagcta ccccactgtg catcatcatc atcatcattg aggatccata gctaacgccc 2100
ctctccctcc ccccccccta acgttactgg ccgaagccgc ttggaataag gccggtgtgc 2160
gtttgtctat atgttatttt ccaccatatt gccgtctttt ggcaatgtga gggcccggaa 2220
acctggccct gtcttcttga cgagcattcc taggggtctt tcccctctcg ccaaaggaat 2280
gcaaggtctg ttgaatgtcg tgaaggaagc agttcctctg gaagcttctt gaagacaaac 2340
aacgtctgta gcgacccttt gcaggcagcg gaacccccca cctggcgaca ggtgcctctg 2400
cggccaaaag ccacgtgtat aagatacacc tgcaaaggcg gcacaacccc agtgccacgt 2460
tgtgagttgg atagttgtgg aaagagtcaa atggctctcc tcaagcgtat tcaacaaggg 2520

gctgaaggat gcccagaagg taccccattg tatgggatct gatctggggc ctcggtgcac 2580
atgctttaca tgtgtttagt cgaggttaaa aaaacgtcta ggccccccga accacgggga 2640
cgtggttttc ctttgaaaaa cacgatgata agcttgccac aacccacagc ggccgctgcc 2700
atcatggttc gaccattgaa ctgcatcgtc gccgtgtccc aaaatatggg gattggcaag 2760
aacggagacc taccctggcc tccgctcagg aacgagttca agtacttcca aagaatgacc 2820
acaacctctt cagtggaagg taaacagaat ctggtgatta tgggtaggaa aacctggttc 2880
tccattcctg agaagaatcg acctttaaag gacagaatta atatagttct cagtagagaa 2940
ctcaaagaac caccacgagg agctcatttt cttgccaaaa gtttggatga tgccttaaga 3000
cttattgaac aaccggaatt ggcaagtaaa gtagacatgg tttggatagt cggaggcagt 3060
tctgtttacc aggaagccat gaatcaacca ggccacctca gactctttgt gacaaggatc 3120
atgcaggaat ttgaaagtga cacgtttttc ccagaaattg atttggggaa atataaactt 3180
ctcccagaat acccaggcgt cctctctgag gtccaggagg aaaaaggcat caagtataag 3240
tttgaagtct acgagaagaa agactaaacg cgtggtacct ctagagtcga cctgggcggc 3300
cgcttcgagc agacatgata agatacattg atgagtttgg acaaaccaca actagaatgc 3360
agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta 3420
taagctgcaa taaacaagtt aacaacaaca attgcattca ttttatgttt caggttcagg 3480
gggagatgtg ggaggttttt taaagcaagt aaaacctcta caaatgtggt aaaatcgata 3540
agtatccggg ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc 3600
gcagcctgaa tggcgaatgg acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt 3660
ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt 3720
cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa atcgggggct 3780
ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac ttgattaggg 3840
tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt tgacgttgga 3900
gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca accctatctc 3960
ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt taaaaaatga 4020
gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgctta caatttcctg 4080
atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatatg gtgcactctc 4140
agtacaatct gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct 4200
gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc 4260
tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag 4320
ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg 4380
tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata 4440

cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga 4500
aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca 4560
ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat 4620
cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag 4680
agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc 4740
gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct 4800
cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca 4860
gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt 4920
ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat 4980
gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt 5040
gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta 5100
cttactctag cttcccggca acaattaata gactggatgg aggcggataa agttgcagga 5160
ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt 5220
gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc 5280
gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct 5340
gagataggtg cctcactgat taagcattgg taactgtcag accaagttta ctcatatata 5400
ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt 5460
gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc 5520
gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg 5580
caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact 5640
ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt tcttctagtg 5700
tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg 5760
ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac 5820
tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca 5880
cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga 5940
gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc 6000
ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct 6060
gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg 6120
agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct 6180
tttgctcaca tggctcgaca gatct                                       6205



<210> 15
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> linker
           

<400> 15
Gly Gly Gly Gly Ser Gly
 1               5      


<210> 16
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> Human Cat-L 5? primer
      
<400> 16
aaggccgcta gccaccatgg atcctacact catccttgct gc                    42


<210> 17
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> Human Cat-L 3? primer
      
<400> 17
gagcacggat cctcatcaca cagtggggta gctgg                            35


<210> 18
<211> 49
<212> DNA
<213> Artificial Sequence

<220> 
<223> Human Cat-L-His primer      

<400> 18
cctgccggat cctcaatgat gatgatgatg atgcacagtg gggtagctg             49


<210> 19
<211> 952
<212> DNA
<213> Homo sapiens

<220> 
<223> Pancreatic elastase (PE1; Elastase-1) precursor
      

<400> 19
ttggtccaag caagaaggca gtggtctact ccatcggcaa catgctggtc ctttatggac 60
acagcaccca ggaccttccg gaaaccaatg cccgcgtagt cggagggact gaggccggga 120
ggaattcctg gccctctcag atttccctcc agtaccggtc tggaggttcc cggtatcaca 180
cctgtggagg gacccttatc agacagaact gggtgatgac agctgctcac tgcgtggatt 240
accagaagac tttccgcgtg gtggctggag accataacct gagccagaat gatggcactg 300
agcagtacgt gagtgtgcag aagatcgtgg tgcatccata ctggaacagc gataacgtgg 360
ctgccggcta tgacatcgcc ctgctgcgcc tggcccagag cgttaccctc aatagctatg 420
tccagctggg tgttctgccc caggagggag ccatcctggc taacaacagt ccctgctaca 480
tcacaggctg gggcaagacc aagaccaatg ggcagctggc ccagaccctg cagcaggctt 540
acctgccctc tgtggactac gccatctgct ccagctcctc ctactggggc tccactgtga 600
agaacaccat ggtgtgtgct ggtggagatg gagttcgctc tggatgccag ggtgactctg 660
ggggccccct ccattgcttg gtgaatggca agtattctgt ccatggagtg accagctttg 720
tgtccagccg gggctgtaat gtctccagga agcctacagt cttcacccag gtctctgctt 780
acatctcctg gataaataat gtcatcgcct ccaactgaac attttcctga gtccaacgac 840
cttcccaaaa tggttcttag atctgcaata ggacttgcga tcaaaaagta aaacacattc 900
tgaaagacta ttgagccatt gatagaaaag caaataaaac tagatataca tt         952

<210> 20
<211> 258
<212> PRT
<213> Homo sapiens

<220> 
<223> Pancreatic elastase (PE1; Elastase-1) precursor
      

<400> 20
Met Leu Val Leu Tyr Gly His Ser Thr Gln Asp Leu Pro Glu Thr Asn
 1               5                  10                  15      
Ala Arg Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser
            20                  25                  30          
Gln Ile Ser Leu Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Thr Cys
        35                  40                  45              
Gly Gly Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys
    50                  55                  60                  
Val Asp Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu
65                  70                  75                  80  
Ser Gln Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val
                85                  90                  95      
Val His Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile
            100                 105                 110         
Ala Leu Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln
        115                 120                 125             
Leu Gly Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro
    130                 135                 140                 
Cys Tyr Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala
145                 150                 155                 160 
Gln Thr Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys
                165                 170                 175     
Ser Ser Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys
            180                 185                 190         
Ala Gly Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly
        195                 200                 205             
Pro Leu His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr
    210                 215                 220                 
Ser Phe Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val
225                 230                 235                 240 
Phe Thr Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala
                245                 250                 255     

Ser Asn
        


<210> 21
<211> 239
<212> PRT
<213> Homo sapiens

<220> 
<223> Pancreatic elastase (PE1; Elastase-1) proprotein
      

<400> 21
Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser
 1               5                  10                  15      
Leu Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Thr Cys Gly Gly Thr
            20                  25                  30          
Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val Asp Tyr
        35                  40                  45              
Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu Ser Gln Asn
    50                  55                  60                  
Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val His Pro
65                  70                  75                  80  
Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu
                85                  90                  95      
Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val
            100                 105                 110         
Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile
        115                 120                 125             
Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu
    130                 135                 140                 
Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser
145                 150                 155                 160 
Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly

                165                 170                 175     
Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His
            180                 185                 190         
Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr Ser Phe Val
        195                 200                 205             
Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln
    210                 215                 220                 
Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser Asn
225                 230                 235                 


<210> 22
<211> 979
<212> DNA
<213> Homo sapiens

<220> 
<223> Elastase-2A precursor

<400> 22
cttacagaac tcccacggac acaccatgat aaggacgctg ctgctgtcca ctttggtggc 60
tggagccctc agttgtgggg accccactta cccaccttat gtgactaggg tggttggcgg 120
tgaagaagcg aggcccaaca gctggccctg gcaggtctcc ctgcagtaca gctccaatgg 180
caagtggtac cacacctgcg gagggtccct gatagccaac agctgggtcc tgacggctgc 240
ccactgcatc agctcctcca ggacctaccg cgtggggctg ggccggcaca acctctacgt 300
tgcggagtcc ggctcgctgg cagtcagtgt ctctaagatt gtggtgcaca aggactggaa 360
ctccaaccaa atctccaaag ggaacgacat tgccctgctc aaactggcta accccgtctc 420
cctcaccgac aagatccagc tggcctgcct ccctcctgcc ggcaccattc tacccaacaa 480
ctacccctgc tacgtcacgg gctggggaag gctgcagacc aacggggctg ttcctgatgt 540
cctgcagcag ggccggttgc tggttgtgga ctatgccacc tgctccagct ctgcctggtg 600
gggcagcagc gtgaaaacca gtatgatctg tgctgggggt gatggcgtga tctccagctg 660
caacggagac tctggcgggc cactgaactg tcaggcgtct gacggccggt ggcaggtgca 720
cggcatcgtc agcttcgggt ctcgcctcgg ctgcaactac taccacaagc cctccgtctt 780
cacgcgggtc tccaattaca tcgactggat caattcggtg attgcaaata actaaccaaa 840
agaagtccct gggactgttt cagacttgga aaggtcacag aaggaaaata atataataaa 900
gtgacaacta tgcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaata aaaaaaaaaa 960
aaaaaaaaaa aaaaaaaaa                                              979

<210> 23
<211> 269
<212> PRT
<213> Homo sapiens

<220> 
<223> Elastase-2A precursor

<400> 23
Met Ile Arg Thr Leu Leu Leu Ser Thr Leu Val Ala Gly Ala Leu Ser
 1               5                  10                  15      
Cys Gly Asp Pro Thr Tyr Pro Pro Tyr Val Thr Arg Val Val Gly Gly
            20                  25                  30          
Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr
        35                  40                  45              
Ser Ser Asn Gly Lys Trp Tyr His Thr Cys Gly Gly Ser Leu Ile Ala
    50                  55                  60                  
Asn Ser Trp Val Leu Thr Ala Ala His Cys Ile Ser Ser Ser Arg Thr
65                  70                  75                  80  
Tyr Arg Val Gly Leu Gly Arg His Asn Leu Tyr Val Ala Glu Ser Gly
                85                  90                  95      
Ser Leu Ala Val Ser Val Ser Lys Ile Val Val His Lys Asp Trp Asn
            100                 105                 110         
Ser Asn Gln Ile Ser Lys Gly Asn Asp Ile Ala Leu Leu Lys Leu Ala
        115                 120                 125             
Asn Pro Val Ser Leu Thr Asp Lys Ile Gln Leu Ala Cys Leu Pro Pro
    130                 135                 140                 
Ala Gly Thr Ile Leu Pro Asn Asn Tyr Pro Cys Tyr Val Thr Gly Trp
145                 150                 155                 160 
Gly Arg Leu Gln Thr Asn Gly Ala Val Pro Asp Val Leu Gln Gln Gly
                165                 170                 175     
Arg Leu Leu Val Val Asp Tyr Ala Thr Cys Ser Ser Ser Ala Trp Trp
            180                 185                 190         
Gly Ser Ser Val Lys Thr Ser Met Ile Cys Ala Gly Gly Asp Gly Val
        195                 200                 205             
Ile Ser Ser Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Gln Ala
    210                 215                 220                 
Ser Asp Gly Arg Trp Gln Val His Gly Ile Val Ser Phe Gly Ser Arg
225                 230                 235                 240 
Leu Gly Cys Asn Tyr Tyr His Lys Pro Ser Val Phe Thr Arg Val Ser
                245                 250                 255     

Asn Tyr Ile Asp Trp Ile Asn Ser Val Ile Ala Asn Asn
            260                 265                 


<210> 24
<211> 241
<212> PRT
<213> Homo sapiens

<220> 
<223> Elastase-2A mature

<400> 24
Val Val Gly Gly Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val
 1               5                  10                  15      
Ser Leu Gln Tyr Ser Ser Asn Gly Lys Trp Tyr His Thr Cys Gly Gly
            20                  25                  30          
Ser Leu Ile Ala Asn Ser Trp Val Leu Thr Ala Ala His Cys Ile Ser
        35                  40                  45              
Ser Ser Arg Thr Tyr Arg Val Gly Leu Gly Arg His Asn Leu Tyr Val
    50                  55                  60                  
Ala Glu Ser Gly Ser Leu Ala Val Ser Val Ser Lys Ile Val Val His
65                  70                  75                  80  
Lys Asp Trp Asn Ser Asn Gln Ile Ser Lys Gly Asn Asp Ile Ala Leu
                85                  90                  95      
Leu Lys Leu Ala Asn Pro Val Ser Leu Thr Asp Lys Ile Gln Leu Ala
            100                 105                 110         
Cys Leu Pro Pro Ala Gly Thr Ile Leu Pro Asn Asn Tyr Pro Cys Tyr
        115                 120                 125             
Val Thr Gly Trp Gly Arg Leu Gln Thr Asn Gly Ala Val Pro Asp Val
    130                 135                 140                 
Leu Gln Gln Gly Arg Leu Leu Val Val Asp Tyr Ala Thr Cys Ser Ser
145                 150                 155                 160 
Ser Ala Trp Trp Gly Ser Ser Val Lys Thr Ser Met Ile Cys Ala Gly
                165                 170                 175     
Gly Asp Gly Val Ile Ser Ser Cys Asn Gly Asp Ser Gly Gly Pro Leu
            180                 185                 190         
Asn Cys Gln Ala Ser Asp Gly Arg Trp Gln Val His Gly Ile Val Ser
        195                 200                 205             
Phe Gly Ser Arg Leu Gly Cys Asn Tyr Tyr His Lys Pro Ser Val Phe
    210                 215                 220                 
Thr Arg Val Ser Asn Tyr Ile Asp Trp Ile Asn Ser Val Ile Ala Asn
225                 230                 235                 240 
Asn
    


<210> 25
<211> 941
<212> DNA
<213> Homo sapiens

<220> 
<223> Elastase-2B precursor

<400> 25
cttacagaac tcccacggac acaccatgat taggaccctg ctgctgtcca ctttggtggc 60
tggagccctc agttgtgggg tctccactta cgcgcctgat atgtctagga tgcttggagg 120
tgaagaagcg aggcccaaca gctggccctg gcaggtctcc ctgcagtaca gctccaatgg 180
ccagtggtac cacacctgcg gagggtccct gatagccaac agctgggtcc tgacggctgc 240
ccactgcatc agctcctccg ggatctaccg cgtgatgctg ggccagcata acctctacgt 300
tgcagagtcc ggctcgctgg ccgtcagtgt ctctaagatt gtggtgcaca aggactggaa 360
ctccgaccag gtctccaaag ggaacgacat tgccctgctc aaactggcta accccgtctc 420
cctcaccgac aagatccagc tggcctgcct ccctcctgcc ggcaccattc tacccaacaa 480
ctacccctgc tacgtcacgg gctggggaag gctgcagacc aacggggctc tccctgatga 540
cctgaagcag ggccggttgc tggttgtgga ctatgccacc tgctccagct ctggctggtg 600
gggcagcacc gtgaagacga atatgatctg tgctgggggt gatggcgtga tatgcacctg 660
caacggagac tccggtgggc cgctgaactg tcaggcatct gacggccggt gggaggtgca 720
tggcatcggc agcctcacgt cggtccttgg ttgcaactac tactacaagc cctccatctt 780
cacgcgggtc tccaactaca acgactggat caattcggtg attgcaaata actaaccaaa 840
agaagtccct gggactgttt cagacttgga aaggtcacag aaggaaaata atattatata 900
aagtgacaac tatgcaaatc acaaaaaaaa aaaaaaaaaa a                     941

<210> 26
<211> 269
<212> PRT
<213> Homo sapiens

<220> 
<223> Elastase-2B precursor

<400> 26
Met Ile Arg Thr Leu Leu Leu Ser Thr Leu Val Ala Gly Ala Leu Ser
 1               5                  10                  15      
Cys Gly Val Ser Thr Tyr Ala Pro Asp Met Ser Arg Met Leu Gly Gly
            20                  25                  30          
Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val Ser Leu Gln Tyr
        35                  40                  45              
Ser Ser Asn Gly Gln Trp Tyr His Thr Cys Gly Gly Ser Leu Ile Ala
    50                  55                  60                  
Asn Ser Trp Val Leu Thr Ala Ala His Cys Ile Ser Ser Ser Arg Ile
65                  70                  75                  80  
Tyr Arg Val Met Leu Gly Gln His Asn Leu Tyr Val Ala Glu Ser Gly
                85                  90                  95      
Ser Leu Ala Val Ser Val Ser Lys Ile Val Val His Lys Asp Trp Asn
            100                 105                 110         
Ser Asn Gln Val Ser Lys Gly Asn Asp Ile Ala Leu Leu Lys Leu Ala
        115                 120                 125             
Asn Pro Val Ser Leu Thr Asp Lys Ile Gln Leu Ala Cys Leu Pro Pro
    130                 135                 140                 
Ala Gly Thr Ile Leu Pro Asn Asn Tyr Pro Cys Tyr Val Thr Gly Trp
145                 150                 155                 160 
Gly Arg Leu Gln Thr Asn Gly Ala Leu Pro Asp Asp Leu Lys Gln Gly
                165                 170                 175     
Arg Leu Leu Val Val Asp Tyr Ala Thr Cys Ser Ser Ser Gly Trp Trp
            180                 185                 190         
Gly Ser Thr Val Lys Thr Asn Met Ile Cys Ala Gly Gly Asp Gly Val
        195                 200                 205             
Ile Cys Thr Cys Asn Gly Asp Ser Gly Gly Pro Leu Asn Cys Gln Ala
    210                 215                 220                 
Ser Asp Gly Arg Trp Glu Val His Gly Ile Gly Ser Leu Thr Ser Val
225                 230                 235                 240 
Leu Gly Cys Asn Tyr Tyr Tyr Lys Pro Ser Ile Phe Thr Arg Val Ser
                245                 250                 255     
Asn Tyr Asn Asp Trp Ile Asn Ser Val Ile Ala Asn Asn
            260                 265                 


<210> 27
<211> 241
<212> PRT
<213> Homo sapiens

<220> 
<223> Elastase-2B mature

<400> 27
Met Leu Gly Gly Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val
 1               5                  10                  15      
Ser Leu Gln Tyr Ser Ser Asn Gly Gln Trp Tyr His Thr Cys Gly Gly
            20                  25                  30          
Ser Leu Ile Ala Asn Ser Trp Val Leu Thr Ala Ala His Cys Ile Ser
        35                  40                  45              
Ser Ser Arg Ile Tyr Arg Val Met Leu Gly Gln His Asn Leu Tyr Val
    50                  55                  60                  
Ala Glu Ser Gly Ser Leu Ala Val Ser Val Ser Lys Ile Val Val His
65                  70                  75                  80  
Lys Asp Trp Asn Ser Asn Gln Val Ser Lys Gly Asn Asp Ile Ala Leu
                85                  90                  95      
Leu Lys Leu Ala Asn Pro Val Ser Leu Thr Asp Lys Ile Gln Leu Ala
            100                 105                 110         
Cys Leu Pro Pro Ala Gly Thr Ile Leu Pro Asn Asn Tyr Pro Cys Tyr
        115                 120                 125             
Val Thr Gly Trp Gly Arg Leu Gln Thr Asn Gly Ala Leu Pro Asp Asp
    130                 135                 140                 
Leu Lys Gln Gly Arg Leu Leu Val Val Asp Tyr Ala Thr Cys Ser Ser
145                 150                 155                 160 
Ser Gly Trp Trp Gly Ser Thr Val Lys Thr Asn Met Ile Cys Ala Gly
                165                 170                 175     
Gly Asp Gly Val Ile Cys Thr Cys Asn Gly Asp Ser Gly Gly Pro Leu
            180                 185                 190         
Asn Cys Gln Ala Ser Asp Gly Arg Trp Glu Val His Gly Ile Gly Ser
        195                 200                 205             
Leu Thr Ser Val Leu Gly Cys Asn Tyr Tyr Tyr Lys Pro Ser Ile Phe
    210                 215                 220                 
Thr Arg Val Ser Asn Tyr Asn Asp Trp Ile Asn Ser Val Ile Ala Asn
225                 230                 235                 240 
Asn
    


<210> 28
<211> 938
<212> DNA
<213> Homo sapiens

<220> 
<223> Neutrophil elastase precursor

<400> 28
gcacggaggg gcagagaccc cggagcccca gccccaccat gaccctcggc cgccgactcg 60
cgtgtctttt cctcgcctgt gtcctgccgg ccttgctgct ggggggcacc gcgctggcct 120
cggagattgt ggggggccgg cgagcgcggc cccacgcgtg gcccttcatg gtgtccctgc 180
agctgcgcgg aggccacttc tgcggcgcca ccctgattgc gcccaacttc gtcatgtcgg 240
ccgcgcactg cgtggcgaat gtaaacgtcc gcgcggtgcg ggtggtcctg ggagcccata 300
acctctcgcg gcgggagccc acccggcagg tgttcgccgt gcagcgcatc ttcgaaaacg 360
gctacgaccc cgtaaacttg ctcaacgaca tcgtgattct ccagctcaac gggtcggcca 420
ccatcaacgc caacgtgcag gtggcccagc tgccggctca gggacgccgc ctgggcaacg 480
gggtgcagtg cctggccatg ggctggggcc ttctgggcag gaaccgtggg atcgccagcg 540
tcctgcagga gctcaacgtg acggtggtga cgtccctctg ccgtcgcagc aacgtctgca 600
ctctcgtgag gggccggcag gccggcgtct gtttcgggga ctccggcagc cccttggtct 660
gcaacgggct aatccacgga attgcctcct tcgtccgggg aggctgcgcc tcagggctct 720
accccgatgc ctttgccccg gtggcacagt ttgtaaactg gatcgactct atcatccaac 780
gctccgagga caacccctgt ccccaccccc gggacccgga cccggccagc aggacccact 840
gagaagggct gcccgggtca cctcagctgc ccacacccac actctccagc atctggcaca 900
ataaacattc tctgttttgt agaaaaaaaa aaaaaaaa                         938

<210> 29
<211> 267
<212> PRT
<213> Homno sapiens

<220> 
<223> Neutrophil elastase precursor

<400> 29
Met Thr Leu Gly Arg Arg Leu Ala Cys Leu Phe Leu Ala Cys Val Leu
 1               5                  10                  15      
Pro Ala Leu Leu Leu Gly Gly Thr Ala Leu Ala Ser Glu Ile Val Gly
            20                  25                  30          
Gly Arg Arg Ala Arg Pro His Ala Trp Pro Phe Met Val Ser Leu Gln
        35                  40                  45              
Leu Arg Gly Gly His Phe Cys Gly Ala Thr Leu Ile Ala Pro Asn Phe
    50                  55                  60                  
Val Met Ser Ala Ala His Cys Val Ala Asn Val Asn Val Arg Ala Val
65                  70                  75                  80  
Arg Val Val Leu Gly Ala His Asn Leu Ser Arg Arg Glu Pro Thr Arg
                85                  90                  95      
Gln Val Phe Ala Val Gln Arg Ile Phe Glu Asn Gly Tyr Asp Pro Val
            100                 105                 110         
Asn Leu Leu Asn Asp Ile Val Ile Leu Gln Leu Asn Gly Ser Ala Thr
        115                 120                 125             
Ile Asn Ala Asn Val Gln Val Ala Gln Leu Pro Ala Gln Gly Arg Arg
    130                 135                 140                 
Leu Gly Asn Gly Val Gln Cys Leu Ala Met Gly Trp Gly Leu Leu Gly
145                 150                 155                 160 
Arg Asn Arg Gly Ile Ala Ser Val Leu Gln Glu Leu Asn Val Thr Val
                165                 170                 175     
Val Thr Ser Leu Cys Arg Arg Ser Asn Val Cys Thr Leu Val Arg Gly
            180                 185                 190         
Arg Gln Ala Gly Val Cys Phe Gly Asp Ser Gly Ser Pro Leu Val Cys
        195                 200                 205             
Asn Gly Leu Ile His Gly Ile Ala Ser Phe Val Arg Gly Gly Cys Ala
    210                 215                 220                 
Ser Gly Leu Tyr Pro Asp Ala Phe Ala Pro Val Ala Gln Phe Val Asn
225                 230                 235                 240 
Trp Ile Asp Ser Ile Ile Gln Arg Ser Glu Asp Asn Pro Cys Pro His
                245                 250                 255     
Pro Arg Asp Pro Asp Pro Ala Ser Arg Thr His
            260                 265         


<210> 30
<211> 238
<212> PRT
<213> Homno sapiens

<220> 
<223> Neutrophil elastase mature

<400> 30
Ile Val Gly Gly Arg Arg Ala Arg Pro His Ala Trp Pro Phe Met Val
 1               5                  10                  15      
Ser Leu Gln Leu Arg Gly Gly His Phe Cys Gly Ala Thr Leu Ile Ala
            20                  25                  30          
Pro Asn Phe Val Met Ser Ala Ala His Cys Val Ala Asn Val Asn Val
        35                  40                  45              
Arg Ala Val Arg Val Val Leu Gly Ala His Asn Leu Ser Arg Arg Glu
    50                  55                  60                  
Pro Thr Arg Gln Val Phe Ala Val Gln Arg Ile Phe Glu Asn Gly Tyr
65                  70                  75                  80  
Asp Pro Val Asn Leu Leu Asn Asp Ile Val Ile Leu Gln Leu Asn Gly
                85                  90                  95      
Ser Ala Thr Ile Asn Ala Asn Val Gln Val Ala Gln Leu Pro Ala Gln
            100                 105                 110         
Gly Arg Arg Leu Gly Asn Gly Val Gln Cys Leu Ala Met Gly Trp Gly
        115                 120                 125             
Leu Leu Gly Arg Asn Arg Gly Ile Ala Ser Val Leu Gln Glu Leu Asn
    130                 135                 140                 
Val Thr Val Val Thr Ser Leu Cys Arg Arg Ser Asn Val Cys Thr Leu
145                 150                 155                 160 
Val Arg Gly Arg Gln Ala Gly Val Cys Phe Gly Asp Ser Gly Ser Pro
                165                 170                 175     
Leu Val Cys Asn Gly Leu Ile His Gly Ile Ala Ser Phe Val Arg Gly
            180                 185                 190         
Gly Cys Ala Ser Gly Leu Tyr Pro Asp Ala Phe Ala Pro Val Ala Gln
        195                 200                 205             
Phe Val Asn Trp Ile Asp Ser Ile Ile Gln Arg Ser Glu Asp Asn Pro
    210                 215                 220                 
Cys Pro His Pro Arg Asp Pro Asp Pro Ala Ser Arg Thr His
225                 230                 235             


<210> 31
<211> 1001
<212> DNA
<213> Homo sapiens

<220> 
<223> Proteinase-3 precursor
      

<400> 31
cgtgggtgca ccctggaccc caccatggct caccggcccc ccagccctgc cctggcgtcc 60
gtgctgctgg ccttgctgct gagcggtgct gcccgagctg cggagatcgt gggcgggcac 120
gaggcgcagc cacactcccg gccctacatg gcctccctgc agatgcgggg gaacccgggc 180
agccacttct gcggaggcac cttgatccac cccagcttcg tgctgacggc cgcgcactgc 240
ctgcgggaca taccccagcg cctggtgaac gtggtgctcg gagcccacaa cgtgcggacg 300
caggagccca cccagcagca cttctcggtg gctcaggtgt ttctgaacaa ctacgacgcg 360
gagaacaaac tgaacgacgt tctcctcatc cagctgagca gcccagccaa cctcagtgcc 420
tccgtcgcca cagtccagct gccacagcag gaccagccag tgccccacgg cacccagtgc 480
ctggccatgg gctggggccg cgtgggtgcc cacgaccccc cagcccaggt cctgcaggag 540
ctcaatgtca ccgtggtcac cttcttctgc cggccacata acatttgcac tttcgtccct 600
cgccgcaagg ccggcatctg cttcggagac tcaggtggcc ccctgatctg tgatggcatc 660
atccaaggaa tagactcctt cgtgatctgg ggatgtgcca cccgcctttt ccctgacttc 720
ttcacgcggg tagccctcta cgtggactgg atccgttcca cgctgcgccg tgtggaggcc 780
aagggccgcc cctgaaccgc ccctcccaca gcgctggccg ggaccccgag cctggctcca 840
aaccctcgag gcggatcttt ggacagaagc agctcttccc cgaacactgt ggcgtccggg 900
acggccccac ccgtcccccc acactccctc ccacggggct ccgggagaca ggccggccct 960
gcacctcacc ccaccgtgac ctcaataaac gttgaaactc c                     1001

<210> 32
<211> 256
<212> PRT
<213> Homo sapiens

<220> 
<223> Proteinase-3 precursor

      

<400> 32
Met Ala His Arg Pro Pro Ser Pro Ala Leu Ala Ser Val Leu Leu Ala
 1               5                  10                  15      
Leu Leu Leu Ser Gly Ala Ala Arg Ala Ala Glu Ile Val Gly Gly His
            20                  25                  30          
Glu Ala Gln Pro His Ser Arg Pro Tyr Met Ala Ser Leu Gln Met Arg
        35                  40                  45              
Gly Asn Pro Gly Ser His Phe Cys Gly Gly Thr Leu Ile His Pro Ser
    50                  55                  60                  
Phe Val Leu Thr Ala Ala His Cys Leu Arg Asp Ile Pro Gln Arg Leu
65                  70                  75                  80  
Val Asn Val Val Leu Gly Ala His Asn Val Arg Thr Gln Glu Pro Thr
                85                  90                  95      
Gln Gln His Phe Ser Val Ala Gln Val Phe Leu Asn Asn Tyr Asp Ala
            100                 105                 110         
Glu Asn Lys Leu Asn Asp Val Leu Leu Ile Gln Leu Ser Ser Pro Ala
        115                 120                 125             
Asn Leu Ser Ala Ser Val Ala Thr Val Gln Leu Pro Gln Gln Asp Gln
    130                 135                 140                 
Pro Val Pro His Gly Thr Gln Cys Leu Ala Met Gly Trp Gly Arg Val
145                 150                 155                 160 
Gly Ala His Asp Pro Pro Ala Gln Val Leu Gln Glu Leu Asn Val Thr
                165                 170                 175     
Val Val Thr Phe Phe Cys Arg Pro His Asn Ile Cys Thr Phe Val Pro
            180                 185                 190         
Arg Arg Lys Ala Gly Ile Cys Phe Gly Asp Ser Gly Gly Pro Leu Ile
        195                 200                 205             
Cys Asp Gly Ile Ile Gln Gly Ile Asp Ser Phe Val Ile Trp Gly Cys
    210                 215                 220                 
Ala Thr Arg Leu Phe Pro Asp Phe Phe Thr Arg Val Ala Leu Tyr Val
225                 230                 235                 240 
Asp Trp Ile Arg Ser Thr Leu Arg Arg Val Glu Ala Lys Gly Arg Pro
                245                 250                 255     


<210> 33
<211> 221
<212> PRT
<213> Homo sapiens

<220> 
<223> Proteinase-3 mature
      

<400> 33
Ile Val Gly Gly His Glu Ala Gln Pro His Ser Arg Pro Tyr Met Ala
 1               5                  10                  15      
Ser Leu Gln Met Arg Gly Asn Pro Gly Ser His Phe Cys Gly Gly Thr
            20                  25                  30          
Leu Ile His Pro Ser Phe Val Leu Thr Ala Ala His Cys Leu Arg Asp
        35                  40                  45              
Ile Pro Gln Arg Leu Val Asn Val Val Leu Gly Ala His Asn Val Arg
    50                  55                  60                  
Thr Gln Glu Pro Thr Gln Gln His Phe Ser Val Ala Gln Val Phe Leu
65                  70                  75                  80  
Asn Asn Tyr Asp Ala Glu Asn Lys Leu Asn Asp Val Leu Leu Ile Gln
                85                  90                  95      
Leu Ser Ser Pro Ala Asn Leu Ser Ala Ser Val Ala Thr Val Gln Leu
            100                 105                 110         
Pro Gln Gln Asp Gln Pro Val Pro His Gly Thr Gln Cys Leu Ala Met
        115                 120                 125             
Gly Trp Gly Arg Val Gly Ala His Asp Pro Pro Ala Gln Val Leu Gln
    130                 135                 140                 
Glu Leu Asn Val Thr Val Val Thr Phe Phe Cys Arg Pro His Asn Ile
145                 150                 155                 160 
Cys Thr Phe Val Pro Arg Arg Lys Ala Gly Ile Cys Phe Gly Asp Ser
                165                 170                 175     
Gly Gly Pro Leu Ile Cys Asp Gly Ile Ile Gln Gly Ile Asp Ser Phe
            180                 185                 190         
Val Ile Trp Gly Cys Ala Thr Arg Leu Phe Pro Asp Phe Phe Thr Arg
        195                 200                 205             
Val Ala Leu Tyr Val Asp Trp Ile Arg Ser Thr Leu Arg
    210                 215                 220     


<210> 34
<211> 846
<212> DNA
<213> Rattus sp.

<220> 
<223> endogenous vascular elastase

<400> 34
atgcacagct ccgtgtacct cgtggctctg gtggtcctgg aggcggctgt atgtgttgcg 60
cagccccgag gtcggattct gggtggccag gaggccatgg cccatgctcg gccctacatg 120
gcttcagtgc aagtgaatgg cacgcacgtg tgcggtggca ccctggtgga tgagcagtgg 180
gtgctgagcg ccgcgcactg catggatgga gtgaccaagg atgaggttgt gcaggtgctc 240
ctgggtgccc actccctgtc cagtcctgaa ccctacaagc atttgtatga tgtgcaaagt 300
gtagtgcttc acccgggcag ccggcctgac agcgttgagg acgacctcat gctctttaag 360
ctctcccaca atgcctcact gggtccccat gtgagacccc tgcccttgca acgcgaggac 420
cgggaggtga aacccggcac gctctgcgat gtggccggtt ggggcgtggt cactcatgcg 480
ggacgcaggc ccgatgtcct gcagcaactg acagtgtcaa tcatggaccg gaacacctgc 540
aatctgcgca cgtaccatga tggggcaatc accaagaaca tgatgtgtgc agagagcaac 600
cgcagggaca cttgcagggg cgactccggc ggtcctctgg tgtgcgggga tgcggtcgaa 660
gctgtggtta cgtggggatc tcgagtctgt ggcaaccgga gaaagccagg tgtctttacc 720
cgcgtggcaa cctacgtgcc gtggattgaa aacgttctga gtggtaacgt gagtgttaac 780
gtgacggcct gaggggacac cggagaccgt gactcacaat aaatgcatgc atctaaaaaa 840
aaaaaa                                                            846

<210> 35
<211> 262
<212> PRT
<213> Rattus sp.

<220> 
<223> Endogenous vascular elastase precursor

<400> 35
His Ser Ser Val Tyr Leu Val Ala Leu Val Val Leu Glu Ala Ala Val
 1               5                  10                  15      
Cys Val Ala Gln Pro Arg Gly Arg Ile Leu Gly Gly Gln Glu Ala Met
            20                  25                  30          
Ala His Ala Arg Pro Tyr Met Ala Ser Val Gln Val Asn Gly Thr His
        35                  40                  45              
Val Cys Gly Gly Thr Leu Val Asp Glu Gln Trp Val Leu Ser Ala Ala
    50                  55                  60                  
His Cys Met Asp Gly Val Thr Lys Asp Glu Val Val Gln Val Leu Leu
65                  70                  75                  80  
Gly Ala His Ser Leu Ser Ser Pro Glu Pro Tyr Lys His Leu Tyr Asp
                85                  90                  95      
Val Gln Ser Val Val Leu His Pro Gly Ser Arg Pro Asp Ser Val Glu
            100                 105                 110         
Asp Asp Leu Met Leu Phe Lys Leu Ser His Asn Ala Ser Leu Gly Pro
        115                 120                 125             
His Val Arg Pro Leu Pro Leu Gln Arg Glu Asp Arg Glu Val Lys Pro
    130                 135                 140                 
Gly Thr Leu Cys Asp Val Ala Gly Trp Gly Val Val Thr His Ala Gly
145                 150                 155                 160 
Arg Arg Pro Asp Val Leu Gln Gln Leu Thr Val Ser Ile Met Asp Arg
                165                 170                 175     
Asn Thr Cys Asn Leu Arg Thr Tyr His Asp Gly Ala Ile Thr Lys Asn
            180                 185                 190         
Met Met Cys Ala Glu Ser Asn Arg Arg Asp Thr Cys Arg Gly Asp Ser
        195                 200                 205             
Gly Gly Pro Leu Val Cys Gly Asp Ala Val Glu Ala Val Val Thr Trp
    210                 215                 220                 
Gly Ser Arg Val Cys Gly Asn Arg Arg Lys Pro Gly Val Phe Thr Arg
225                 230                 235                 240 
Val Ala Thr Tyr Val Pro Trp Ile Glu Asn Val Leu Ser Gly Asn Val
                245                 250                 255     
Ser Val Asn Val Thr Ala
            260         


<210> 36
<211> 238
<212> PRT
<213> Rattus sp.

<220> 
<223> endogenous vascular elastase mature

<400> 36
Ile Leu Gly Gly Gln Glu Ala Met Ala His Ala Arg Pro Tyr Met Ala
 1               5                  10                  15      
Ser Val Gln Val Asn Gly Thr His Val Cys Gly Gly Thr Leu Val Asp
            20                  25                  30          
Glu Gln Trp Val Leu Ser Ala Ala His Cys Met Asp Gly Val Thr Lys
        35                  40                  45              
Asp Glu Val Val Gln Val Leu Leu Gly Ala His Ser Leu Ser Ser Pro
    50                  55                  60                  
Glu Pro Tyr Lys His Leu Tyr Asp Val Gln Ser Val Val Leu His Pro
65                  70                  75                  80  
Gly Ser Arg Pro Asp Ser Val Glu Asp Asp Leu Met Leu Phe Lys Leu
                85                  90                  95      
Ser His Asn Ala Ser Leu Gly Pro His Val Arg Pro Leu Pro Leu Gln
            100                 105                 110         
Arg Glu Asp Arg Glu Val Lys Pro Gly Thr Leu Cys Asp Val Ala Gly
        115                 120                 125             
Trp Gly Val Val Thr His Ala Gly Arg Arg Pro Asp Val Leu Gln Gln
    130                 135                 140                 
Leu Thr Val Ser Ile Met Asp Arg Asn Thr Cys Asn Leu Arg Thr Tyr
145                 150                 155                 160 
His Asp Gly Ala Ile Thr Lys Asn Met Met Cys Ala Glu Ser Asn Arg
                165                 170                 175     
Arg Asp Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Asp
            180                 185                 190         
Ala Val Glu Ala Val Val Thr Trp Gly Ser Arg Val Cys Gly Asn Arg
        195                 200                 205             
Arg Lys Pro Gly Val Phe Thr Arg Val Ala Thr Tyr Val Pro Trp Ile
    210                 215                 220                 
Glu Asn Val Leu Ser Gly Asn Val Ser Val Asn Val Thr Ala
225                 230                 235             


<210> 37
<211> 924
<212> DNA
<213> Homo sapiens

<220> 
<223> Cathepsin G precursor

<400> 37
gcacagcagc aactgactgg gcagcctttc aggaaagatg cagccactcc tgcttctgct 60
ggcctttctc ctacccactg gggctgaggc aggggagatc atcggaggcc gggagagcag 120
gccccactcc cgcccctaca tggcgtatct tcagatccag agtccagcag gtcagagcag 180
atgtggaggg ttcctggtgc gagaagactt tgtgctgaca gcagctcatt gctggggaag 240
caatataaat gtcaccctgg gcgcccacaa tatccagaga cgggaaaaca cccagcaaca 300
catcactgcg cgcagagcca tccgccaccc tcaatataat cagcggacca tccagaatga 360
catcatgtta ttgcagctga gcagaagagt cagacggaat cgaaacgtga acccagtggc 420
tctgcctaga gcccaggagg gactgagacc cgggacgctg tgcactgtgg ccggctgggg 480
cagggtcagc atgaggaggg gaacagatac actccgagag gtgcagctga gagtgcagag 540
ggataggcag tgcctccgca tcttcggttc ctacgacccc cgaaggcaga tttgtgtggg 600
ggaccggcgg gaacggaagg ctgccttcaa gggggattcc ggaggccccc tgctgtgtaa 660
caatgtggcc cacggcatcg tctcctatgg aaagtcgtca ggggttcctc cagaagtctt 720
caccagggtc tcaagtttcc tgccctggat aaggacaaca atgagaagct tcaaactgct 780
ggatcagatg gagacccccc tgtgactgac tcttcttctc ggggacacag gccagctcca 840
cagtgttgcc agagccttaa taaacgtcca cagagtataa ataaccaatt cctcatttgt 900
tcattaaacg tcattcagta ctta                                        924

<210> 38
<211> 255
<212> PRT
<213> Homo sapiens

<220> 
<223> Cathepsin G precursor

<400> 38
Met Gln Pro Leu Leu Leu Leu Leu Ala Phe Leu Leu Pro Thr Gly Ala
 1               5                  10                  15      
Glu Ala Gly Glu Ile Ile Gly Gly Arg Glu Ser Arg Pro His Ser Arg
            20                  25                  30          
Pro Tyr Met Ala Tyr Leu Gln Ile Gln Ser Pro Ala Gly Gln Ser Arg
        35                  40                  45              
Cys Gly Gly Phe Leu Val Arg Glu Asp Phe Val Leu Thr Ala Ala His
    50                  55                  60                  
Cys Trp Gly Ser Asn Ile Asn Val Thr Leu Gly Ala His Asn Ile Gln
65                  70                  75                  80  
Arg Arg Glu Asn Thr Gln Gln His Ile Thr Ala Arg Arg Ala Ile Arg
                85                  90                  95      
His Pro Gln Tyr Asn Gln Arg Thr Ile Gln Asn Asp Ile Met Leu Leu
            100                 105                 110         
Gln Leu Ser Arg Arg Val Arg Arg Asn Arg Asn Val Asn Pro Val Ala
        115                 120                 125             
Leu Pro Arg Ala Gln Glu Gly Leu Arg Pro Gly Thr Leu Cys Thr Val
    130                 135                 140                 
Ala Gly Trp Gly Arg Val Ser Met Arg Arg Gly Thr Asp Thr Leu Arg
145                 150                 155                 160 
Glu Val Gln Leu Arg Val Gln Arg Asp Arg Gln Cys Leu Arg Ile Phe
                165                 170                 175     
Gly Ser Tyr Asp Pro Arg Arg Gln Ile Cys Val Gly Asp Arg Arg Glu
            180                 185                 190         
Arg Lys Ala Ala Phe Lys Gly Asp Ser Gly Gly Pro Leu Leu Cys Asn
        195                 200                 205             
Asn Val Ala His Gly Ile Val Ser Tyr Gly Lys Ser Ser Gly Val Pro
    210                 215                 220                 
Pro Glu Val Phe Thr Arg Val Ser Ser Phe Leu Pro Trp Ile Arg Thr
225                 230                 235                 240 
Thr Met Arg Ser Phe Lys Leu Leu Asp Gln Met Glu Thr Pro Leu
                245                 250                 255 


<210> 39
<211> 235
<212> PRT
<213> Homo sapiens

<220> 
<223> Cathepsin G mature

<400> 39
Ile Ile Gly Gly Arg Glu Ser Arg Pro His Ser Arg Pro Tyr Met Ala
 1               5                  10                  15      
Tyr Leu Gln Ile Gln Ser Pro Ala Gly Gln Ser Arg Cys Gly Gly Phe
            20                  25                  30          
Leu Val Arg Glu Asp Phe Val Leu Thr Ala Ala His Cys Trp Gly Ser
        35                  40                  45              
Asn Ile Asn Val Thr Leu Gly Ala His Asn Ile Gln Arg Arg Glu Asn
    50                  55                  60                  
Thr Gln Gln His Ile Thr Ala Arg Arg Ala Ile Arg His Pro Gln Tyr
65                  70                  75                  80  
Asn Gln Arg Thr Ile Gln Asn Asp Ile Met Leu Leu Gln Leu Ser Arg
                85                  90                  95      
Arg Val Arg Arg Asn Arg Asn Val Asn Pro Val Ala Leu Pro Arg Ala
            100                 105                 110         
Gln Glu Gly Leu Arg Pro Gly Thr Leu Cys Thr Val Ala Gly Trp Gly
        115                 120                 125             
Arg Val Ser Met Arg Arg Gly Thr Asp Thr Leu Arg Glu Val Gln Leu
    130                 135                 140                 
Arg Val Gln Arg Asp Arg Gln Cys Leu Arg Ile Phe Gly Ser Tyr Asp
145                 150                 155                 160 
Pro Arg Arg Gln Ile Cys Val Gly Asp Arg Arg Glu Arg Lys Ala Ala
                165                 170                 175     
Phe Lys Gly Asp Ser Gly Gly Pro Leu Leu Cys Asn Asn Val Ala His
            180                 185                 190         
Gly Ile Val Ser Tyr Gly Lys Ser Ser Gly Val Pro Pro Glu Val Phe
        195                 200                 205             
Thr Arg Val Ser Ser Phe Leu Pro Trp Ile Arg Thr Thr Met Arg Ser
    210                 215                 220                 
Phe Lys Leu Leu Asp Gln Met Glu Thr Pro Leu
225                 230                 235 


<210> 40
<211> 784
<212> DNA
<213> Homo sapiens

<220> 
<223> mast cell chymase precursor

<400> 40
agcatttgct caggcagcct ctctgggaag atgctgcttc ttcctctccc cctgctgctc 60
tttctcttgt gctccagagc tgaagctggg gagatcatcg ggggcacaga atgcaagcca 120
cattcccgcc cctacatggc ctacctggaa attgtaactt ccaacggtcc ctcaaaattt 180
tgtggtggtt tccttataag acggaacttt gtgctgacgg ctgctcattg tgcaggaagg 240
tctataacag tcacccttgg agcccataac ataacagagg aagaagacac atggcagaag 300
cttgaggtta taaagcaatt ccgtcatcca aaatataaca cttctactct tcaccacgat 360
atcatgttac taaagttgaa ggagaaagcc agcctgaccc tggctgtggg gacactcccc 420
ttcccatcac aattcaactt tgtcccacct gggagaatgt gccgggtggc tggctgggga 480
agaacaggtg tgttgaagcc gggctcagac actctgcaag aggtgaagct gagactcatg 540
gatccccagg cctgcagcca cttcagagac tttgaccaca atcttcagct gtgtgtgggc 600
aatcccagga agacaaaatc tgcatttaag ggagactctg ggggccctct tctgtgtgct 660
ggggtggccc agggcatcgt atcctatgga cggtcggatg caaagccccc tgctgtcttc 720
acccgaatct cccattaccg gccctggatc aaccagatcc tgcaggcaaa ttaatcctgg 780
atcc                                                              784

<210> 41
<211> 247
<212> PRT
<213> Homo sapiens

<220> 
<223> Mast cell chymase precursor

<400> 41
Met Leu Leu Leu Pro Leu Pro Leu Leu Leu Phe Leu Leu Cys Ser Arg
 1               5                  10                  15      
Ala Glu Ala Gly Glu Ile Ile Gly Gly Thr Glu Cys Lys Pro His Ser
            20                  25                  30          
Arg Pro Tyr Met Ala Tyr Leu Glu Ile Val Thr Ser Asn Gly Pro Ser
        35                  40                  45              
Lys Phe Cys Gly Gly Phe Leu Ile Arg Arg Asn Phe Val Leu Thr Ala
    50                  55                  60                  
Ala His Cys Ala Gly Arg Ser Ile Thr Val Thr Leu Gly Ala His Asn
65                  70                  75                  80  
Ile Thr Glu Glu Glu Asp Thr Trp Gln Lys Leu Glu Val Ile Lys Gln
                85                  90                  95      
Phe Arg His Pro Lys Tyr Asn Thr Ser Thr Leu His His Asp Ile Met
            100                 105                 110         
Leu Leu Lys Leu Lys Glu Lys Ala Ser Leu Thr Leu Ala Val Gly Thr
        115                 120                 125             
Leu Pro Phe Pro Ser Gln Phe Asn Phe Val Pro Pro Gly Arg Met Cys
    130                 135                 140                 
Arg Val Ala Gly Trp Gly Arg Thr Gly Val Leu Lys Pro Gly Ser Asp
145                 150                 155                 160 
Thr Leu Gln Glu Val Lys Leu Arg Leu Met Asp Pro Gln Ala Cys Ser
                165                 170                 175     
His Phe Arg Asp Phe Asp His Asn Leu Gln Leu Cys Val Gly Asn Pro
            180                 185                 190         
Arg Lys Thr Lys Ser Ala Phe Lys Gly Asp Ser Gly Gly Pro Leu Leu
        195                 200                 205             
Cys Ala Gly Val Ala Gln Gly Ile Val Ser Tyr Gly Arg Ser Asp Ala
    210                 215                 220                 
Lys Pro Pro Ala Val Phe Thr Arg Ile Ser His Tyr Arg Pro Trp Ile
225                 230                 235                 240 
Asn Gln Ile Leu Gln Ala Asn
                245         


<210> 42
<211> 226
<212> PRT
<213> Homo sapiens

<220> 
<223> Mast cell chymase mature

<400> 42
Ile Ile Gly Gly Thr Glu Cys Lys Pro His Ser Arg Pro Tyr Met Ala
 1               5                  10                  15      
Tyr Leu Glu Ile Val Thr Ser Asn Gly Pro Ser Lys Phe Cys Gly Gly
            20                  25                  30          
Phe Leu Ile Arg Arg Asn Phe Val Leu Thr Ala Ala His Cys Ala Gly
        35                  40                  45              
Arg Ser Ile Thr Val Thr Leu Gly Ala His Asn Ile Thr Glu Glu Glu
    50                  55                  60                  
Asp Thr Trp Gln Lys Leu Glu Val Ile Lys Gln Phe Arg His Pro Lys
65                  70                  75                  80  
Tyr Asn Thr Ser Thr Leu His His Asp Ile Met Leu Leu Lys Leu Lys
                85                  90                  95      
Glu Lys Ala Ser Leu Thr Leu Ala Val Gly Thr Leu Pro Phe Pro Ser
            100                 105                 110         
Gln Phe Asn Phe Val Pro Pro Gly Arg Met Cys Arg Val Ala Gly Trp
        115                 120                 125             
Gly Arg Thr Gly Val Leu Lys Pro Gly Ser Asp Thr Leu Gln Glu Val
    130                 135                 140                 
Lys Leu Arg Leu Met Asp Pro Gln Ala Cys Ser His Phe Arg Asp Phe
145                 150                 155                 160 
Asp His Asn Leu Gln Leu Cys Val Gly Asn Pro Arg Lys Thr Lys Ser
                165                 170                 175     
Ala Phe Lys Gly Asp Ser Gly Gly Pro Leu Leu Cys Ala Gly Val Ala
            180                 185                 190         
Gln Gly Ile Val Ser Tyr Gly Arg Ser Asp Ala Lys Pro Pro Ala Val
        195                 200                 205             
Phe Thr Arg Ile Ser His Tyr Arg Pro Trp Ile Asn Gln Ile Leu Gln
    210                 215                 220                 
Ala Asn
225     


<210> 43
<211> 855
<212> DNA
<213> Homo sapiens

<220> 
<223> Mast cell tryptase precursor

<400> 43
aggcccacga tgctcctcct tgctccccag atgctgagcc tgctgctgct ggcgctgccc 60
gtcctggcga gcccggccta cgtggcccct gccccaggcc aggccctgca gcaaacgggc 120
attgttgggg ggcaggaggc ccccaggagc aagtggccct ggcaggtgag cctgagagtc 180
cgcggcccat actggatgca cttctgcggg ggctccctca tccaccccca gtgggtgcta 240
accgcggcgc actgcgtgga accggacatc aaggatctgg ccgccctcag ggtgcaactg 300
cgggagcagc acctctacta ccaggaccag ctgctgccgg tcagcaggat catcgtgcac 360
ccacagttct acatcatcca gaccggggcg gacatcgccc tgctggagct ggaggagccc 420
gtgaacatct ccagccacat ccacacggtc acgctgcccc ctgcctcgga gaccttcccc 480
ccggggatgc cgtgctgggt cactggctgg ggcgacgtgg acaataatgt gcacctgccg 540
ccgccatacc cgctgaagga ggtggaagtc cccgtagtgg aaaaccacct ttgcaacgcg 600
gaatatcaca ccggcctcca tacgggccac agctttcaaa tcgtccgcga tgacatgctg 660
tgtgcgggga gcgaaaatca cgactcctgc cagggtgact ctggagggcc cctggtctgc 720
aaggtgaatg gcacctaact gcaggcgggc gtggtcagct gggaggagag ctgtgcccag 780
cccaaccggc ctggcatcta cacccgtgtc acctactact tggactggat ccaccactat 840
gtccccaaga agccc                                                  855

<210> 44
<211> 242
<212> PRT
<213> Homo sapiens

<220> 
<223> Mast cell tryptase precursor

<400> 44
Met Leu Leu Leu Ala Pro Gln Met Leu Ser Leu Leu Leu Leu Ala Leu
 1               5                  10                  15      
Pro Val Leu Ala Ser Pro Ala Tyr Val Ala Pro Ala Pro Gly Gln Ala
            20                  25                  30          
Leu Gln Gln Thr Gly Ile Val Gly Gly Gln Glu Ala Pro Arg Ser Lys
        35                  40                  45              
Trp Pro Trp Gln Val Ser Leu Arg Val Arg Gly Pro Tyr Trp Met His
    50                  55                  60                  
Phe Cys Gly Gly Ser Leu Ile His Pro Gln Trp Val Leu Thr Ala Ala
65                  70                  75                  80  
His Cys Val Glu Pro Asp Ile Lys Asp Leu Ala Ala Leu Arg Val Gln
                85                  90                  95      
Leu Arg Glu Gln His Leu Tyr Tyr Gln Asp Gln Leu Leu Pro Val Ser
            100                 105                 110         
Arg Ile Ile Val His Pro Gln Phe Tyr Ile Ile Gln Thr Gly Ala Asp
        115                 120                 125             
Ile Ala Leu Leu Glu Leu Glu Glu Pro Val Asn Ile Ser Ser His Ile
    130                 135                 140                 
His Thr Val Thr Leu Pro Pro Ala Ser Glu Thr Phe Pro Pro Gly Met
145                 150                 155                 160 
Pro Cys Trp Val Thr Gly Trp Gly Asp Val Asp Asn Asn Val His Leu
                165                 170                 175     
Pro Pro Pro Tyr Pro Leu Lys Glu Val Glu Val Pro Val Val Glu Asn
            180                 185                 190         
His Leu Cys Asn Ala Glu Tyr His Thr Gly Leu His Thr Gly His Ser
        195                 200                 205             
Phe Gln Ile Val Arg Asp Asp Met Leu Cys Ala Gly Ser Glu Asn His
    210                 215                 220                 
Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Lys Val Asn
225                 230                 235                 240 
Gly Thr
        


<210> 45
<211> 205
<212> PRT
<213> Homo sapiens

<220> 
<223> Mast cell tryptase mature

<400> 45
Ile Val Gly Gly Gln Glu Ala Pro Arg Ser Lys Trp Pro Trp Gln Val
 1               5                  10                  15      
Ser Leu Arg Val Arg Gly Pro Tyr Trp Met His Phe Cys Gly Gly Ser
            20                  25                  30          
Leu Ile His Pro Gln Trp Val Leu Thr Ala Ala His Cys Val Glu Pro
        35                  40                  45              
Asp Ile Lys Asp Leu Ala Ala Leu Arg Val Gln Leu Arg Glu Gln His
    50                  55                  60                  
Leu Tyr Tyr Gln Asp Gln Leu Leu Pro Val Ser Arg Ile Ile Val His
65                  70                  75                  80  
Pro Gln Phe Tyr Ile Ile Gln Thr Gly Ala Asp Ile Ala Leu Leu Glu
                85                  90                  95      
Leu Glu Glu Pro Val Asn Ile Ser Ser His Ile His Thr Val Thr Leu
            100                 105                 110         
Pro Pro Ala Ser Glu Thr Phe Pro Pro Gly Met Pro Cys Trp Val Thr
        115                 120                 125             
Gly Trp Gly Asp Val Asp Asn Asn Val His Leu Pro Pro Pro Tyr Pro
    130                 135                 140                 
Leu Lys Glu Val Glu Val Pro Val Val Glu Asn His Leu Cys Asn Ala
145                 150                 155                 160 
Glu Tyr His Thr Gly Leu His Thr Gly His Ser Phe Gln Ile Val Arg
                165                 170                 175     
Asp Asp Met Leu Cys Ala Gly Ser Glu Asn His Asp Ser Cys Gln Gly
            180                 185                 190         
Asp Ser Gly Gly Pro Leu Val Cys Lys Val Asn Gly Thr
        195                 200                 205 


<210> 46
<211> 2732
<212> DNA
<213> Homo sapiens

<220> 
<223> plasmin precursor

<400> 46
aacaacatcc tgggattggg acccactttc tgggcactgc tggccagtcc caaaatggaa 60
cataaggaag tggttcttct acttctttta tttctgaaat caggtcaagg agagcctctg 120
gatgactatg tgaataccca gggggcttca ctgttcagtg tcactaagaa gcagctggga 180
gcaggaagta tagaagaatg tgcagcaaaa tgtgaggagg acgaagaatt cacctgcagg 240
gcattccaat atcacagtaa agagcaacaa tgtgtgataa tggctgaaaa caggaagtcc 300
tccataatca ttaggatgag agatgtagtt ttatttgaaa agaaagtgta tctctcagag 360
tgcaagactg ggaatggaaa gaactacaga gggacgatgt ccaaaacaaa aaatggcatc 420
acctgtcaaa aatggagttc cacttctccc cacagaccta gattctcacc tgctacacac 480
ccctcagagg gactggagga gaactactgc aggaatccag acaacgatcc gcaggggccc 540
tggtgctata ctactgatcc agaaaagaga tatgactact gcgacattct tgagtgtgaa 600
gaggaatgta tgcattgcag tggagaaaac tatgacggca aaatttccaa gaccatgtct 660
ggactggaat gccaggcctg ggactctcag agcccacacg ctcatggata cattccttcc 720
aaatttccaa acaagaacct gaagaagaat tactgtcgta accccgatag ggagctgcgg 780
ccttggtgtt tcaccaccga ccccaacaag cgctgggaac tttgcgacat cccccgctgc 840
acaacacctc caccatcttc tggtcccacc taccagtgtc tgaagggaac aggtgaaaac 900
tatcgcggga atgtggctgt taccgtttcc gggcacacct gtcagcactg gagtgcacag 960
acccctcaca cacataacag gacaccagaa aacttcccct gcaaaaattt ggatgaaaac 1020
tactgccgca atcctgacgg aaaaagggcc ccatggtgcc atacaaccaa cagccaagtg 1080
cggtgggagt actgtaagat accgtcctgt gactcctccc cagtatccac ggaacaattg 1140
gctcccacag caccacctga gctaacccct gtggtccagg actgctacca tggtgatgga 1200
cagagctacc gaggcacatc ctccaccacc accacaggaa agaagtgtca gtcttggtca 1260
tctatgacac cacaccggca ccagaagacc ccagaaaact acccaaatgc tggcctgaca 1320
atgaactact gcaggaatcc agatgccgat aaaggcccct ggtgttttac cacagacccc 1380
agcgtcaggt gggagtactg caacctgaaa aaatgctcag gaacagaagc gagtgttgta 1440
gcacctccgc ctgttgtcct gcttccagat gtagagactc cttccgaaga agactgtatg 1500
tttgggaatg ggaaaggata ccgaggcaag agggcgacca ctgttactgg gacgccatgc 1560
caggactggg ctgcccagga gccccataga cacagcattt tcactccaga gacaaatcca 1620
cgggcgggtc tggaaaaaaa ttactgccgt aaccctgatg gtgatgtagg tggtccctgg 1680
tgctacacga caaatccaag aaaactttac gactactgtg atgtccctca gtgtgcggcc 1740
ccttcatttg attgtgggaa gcctcaagtg gagccgaaga aatgtcctgg aagggttgtg 1800
ggggggtgtg tggcccaccc acattcctgg ccctggcaag tcagtcttag aacaaggttt 1860
ggaatgcact tctgtggagg caccttgata tccccagagt gggtgttgac tgctgcccac 1920
tgcttggaga agtccccaag gccttcatcc tacaaggtca tcctgggtgc acaccaagaa 1980
gtgaatctcg aaccgcatgt tcaggaaata gaagtgtcta ggctgttctt ggagcccaca 2040
cgaaaagata ttgccttgct aaagctaagc agtcctgccg tcatcactga caaagtaatc 2100
ccagcttgtc tgccatcccc aaattatgtg gtcgctgacc ggaccgaatg tttcatcact 2160
ggctggggag aaacccaagg tacttttgga gctggccttc tcaaggaagc ccagctccct 2220
gtgattgaga ataaagtgtg caatcgctat gagtttctga atggaagagt ccaatccacc 2280
gaactctgtg ctgggcattt ggccggaggc actgacagtt gccagggtga cagtggaggt 2340
cctctggttt gcttcgagaa ggacaaatac attttacaag gagtcacttc ttggggtctt 2400
ggctgtgcac gccccaataa gcctggtgtc tatgttcgtg tttcaaggtt tgttacttgg 2460
attgagggag tgatgagaaa taattaattg gacgggagac agagtgacgc actgactcac 2520
ctagaggctg ggacgtgggt agggatttag catgctggaa ataactggca gtaatcaaac 2580
gaagacactg tccccagcta ccagctacgc caaacctcgg cattttttgt gttattttct 2640
gactgctgga ttctgtagta aggtgacata gctatgacat ttgttaaaaa taaactctgt 2700
acttaacttt gatttgagta aattttggtt tt                               2732

<210> 47
<211> 810
<212> PRT
<213> Homo sapiens

<220> 
<223> plasmin precursor

<400> 47
Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser
 1               5                  10                  15      
Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser
            20                  25                  30          
Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu
        35                  40                  45              
Cys Ala Ala Lys Cys Glu Glu Asp Glu Glu Phe Thr Cys Arg Ala Phe
    50                  55                  60                  
Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg
65                  70                  75                  80  
Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys
                85                  90                  95      
Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg
            100                 105                 110         
Gly Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser
        115                 120                 125             
Ser Thr Ser Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser
    130                 135                 140                 
Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln
145                 150                 155                 160 
Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys
                165                 170                 175     
Asp Ile Leu Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn
            180                 185                 190         
Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala
        195                 200                 205             
Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe
    210                 215                 220                 
Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Arg Glu
225                 230                 235                 240 
Leu Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu
                245                 250                 255     
Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr
            260                 265                 270         
Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala
        275                 280                 285             
Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro
    290                 295                 300                 
His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp
305                 310                 315                 320 
Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His
                325                 330                 335     
Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys
            340                 345                 350         
Asp Ser Ser Pro Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro
        355                 360                 365             
Glu Leu Thr Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser
    370                 375                 380                 
Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser
385                 390                 395                 400 
Trp Ser Ser Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr
                405                 410                 415     
Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp
            420                 425                 430         
Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr
        435                 440                 445             
Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro
    450                 455                 460                 
Pro Pro Val Val Leu Leu Pro Asp Val Glu Thr Pro Ser Glu Glu Asp
465                 470                 475                 480 
Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr
                485                 490                 495     
Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg
            500                 505                 510         
His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys
        515                 520                 525             
Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr
    530                 535                 540                 
Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys
545                 550                 555                 560 
Ala Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys
                565                 570                 575     
Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp
            580                 585                 590         
Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly
        595                 600                 605             
Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu
    610                 615                 620                 
Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His
625                 630                 635                 640 
Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg
                645                 650                 655     
Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser
            660                 665                 670         
Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser
        675                 680                 685             
Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp
    690                 695                 700                 
Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln
705                 710                 715                 720 
Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn
                725                 730                 735     
Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly
            740                 745                 750         
Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu
        755                 760                 765             
Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys
    770                 775                 780                 
Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val
785                 790                 795                 800 
Thr Trp Ile Glu Gly Val Met Arg Asn Asn
                805                 810 


<210> 48
<211> 713
<212> PRT
<213> Homo sapiens

<220> 
<223> plasmin mature

<400> 48
Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg Gly
 1               5                  10                  15      
Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser Ser
            20                  25                  30          
Thr Ser Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser Glu
        35                  40                  45              
Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln Gly
    50                  55                  60                  
Pro Trp Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys Asp
65                  70                  75                  80  
Ile Leu Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn Tyr
                85                  90                  95      
Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala Trp
            100                 105                 110         
Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe Pro
        115                 120                 125             
Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Arg Glu Leu
    130                 135                 140                 
Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu Cys
145                 150                 155                 160 
Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr Tyr
                165                 170                 175     
Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala Val
            180                 185                 190         
Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro His
        195                 200                 205             
Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp Glu
    210                 215                 220                 
Asn Tyr Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His Thr
225                 230                 235                 240 
Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys Asp
                245                 250                 255     
Ser Ser Pro Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro Glu
            260                 265                 270         
Leu Thr Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser Tyr
        275                 280                 285             
Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser Trp
    290                 295                 300                 
Ser Ser Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr Pro
305                 310                 315                 320 
Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp Lys
                325                 330                 335     
Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr Cys
            340                 345                 350         
Asn Leu Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro Pro
        355                 360                 365             
Pro Val Val Leu Leu Pro Asp Val Glu Thr Pro Ser Glu Glu Asp Cys
    370                 375                 380                 
Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr Val
385                 390                 395                 400 
Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg His
                405                 410                 415     
Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys Asn
            420                 425                 430         
Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr Thr
        435                 440                 445             
Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys Ala
    450                 455                 460                 
Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys Cys
465                 470                 475                 480 
Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp Pro
                485                 490                 495     
Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly Gly
            500                 505                 510         
Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu Glu
        515                 520                 525             
Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His Gln
    530                 535                 540                 
Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg Leu
545                 550                 555                 560 
Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser Ser
                565                 570                 575     
Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser Pro
            580                 585                 590         
Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp Gly
        595                 600                 605             
Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln Leu
    610                 615                 620                 
Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn Gly
625                 630                 635                 640 
Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly Thr
                645                 650                 655     
Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu Lys
            660                 665                 670         
Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys Ala
        675                 680                 685             
Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val Thr
    690                 695                 700                 
Trp Ile Glu Gly Val Met Arg Asn Asn
705                 710             


<210> 49
<211> 1997
<212> DNA
<213> Homo sapiens

<220> 
<223> thrombin precursor

<400> 49
aattcctcag tgacccagga gctgacacac tatggcgcac gtccgaggct tgcagctgcc 60
tggctgcctg gccctggctg ccctgtgtag ccttgtgcac agccagcatg tgttcctggc 120
tcctcagcaa gcacggtcgc tgctccagcg ggtccggcga gccaacacct tcttggagga 180
ggtgcgcaag ggcaacctag agcgagagtg cgtggaggag acgtgcagct acgaggaggc 240
cttcgaggct ctggagtcct ccacggctac ggatgtgttc tgggccaagt acacagcttg 300
tgagacagcg aggacgcctc gagataagct tgctgcatgt ctggaaggta actgtgctga 360
gggtctgggt acgaactacc gagggcatgt gaacatcacc cggtcaggca ttgagtgcca 420
gctatggagg agtcgctacc cacataagcc tgaaatcaac tccactaccc atcctggggc 480
cgacctacag gagaatttct gccgcaaccc cgacagcagc accacgggac cctggtgcta 540
cactacagac cccaccgtga ggaggcagga atgcagcatc cctgtctgtg gccaggatca 600
agtcactgta gcgatgactc cacgctccga aggctccagt gtgaatctgt cacctccatt 660
ggagcagtgt gtccctgatc gggggcagca gtaccagggg cgcctggcgg tgaccacaca 720
tgggctcccc tgcctggcct gggccagcgc acaggccaag gccctgagca agcaccagga 780
cttcaactca gctgtgcagc tggtggagaa cttctgccgc aacccagacg gggatgagga 840
gggcgtgtgg tgctatgtgg ccgggaagcc tggcgacttt gggtactgcg acctcaacta 900
ttgtgaggag gccgtggagg aggagacagg agatgggctg gatgaggact cagacagggc 960
catcgaaggg cgtaccgcca ccagtgagta ccagactttc ttcaatccga ggacctttgg 1020
ctcgggagag gcagactgtg ggctgcgacc tctgttcgag aagaagtcgc tggaggacaa 1080
aaccgaaaga gagctcctgg aatcctacat cgacgggcgc attgtggagg gctcggatgc 1140
agagatcggc atgtcacctt ggcaggtgat gcttttccgg aagagtcccc aggagctgct 1200
gtgtggggcc agcctcatca gtgaccgctg ggtcctcacc gccgcccact gcctcctgta 1260
cccgccctgg gacaagaact tcaccgagaa tgaccttctg gtgcgcattg gcaagcactc 1320
ccgcacaagg tacgagcgaa acattgaaaa gatatccatg ttggaaaaga tctacatcca 1380
ccccaggtac aactggcggg agaacctgga ccgggacatt gccctgatga agctgaagaa 1440
gcctgttgcc ttcagtgact acattcaccc tgtgtgtctg cccgacaggg agacggcagc 1500
cagcttgctc caggctggat acaaggggcg ggtgacaggc tggggcaacc tgaaggagac 1560
gtggacagcc aacgttggta aggggcagcc cagtgtcctg caggtggtga acctgcccat 1620
tgtggagcgg ccggtctgca aggactccac ccggatccgc atcactgaca acatgttctg 1680
tgctggttac aagcctgatg aagggaaacg aggggatgcc tgtgaaggtg acagtggggg 1740
accctttgtc atgaagagcc cctttaacaa ccgctggtat caaatgggca tcgtctcatg 1800
gggtgaaggc tgtgaccggg atgggaaata tggcttctac acacatgtgt tccgcctgaa 1860
gaagtggata cagaaggtca ttgatcagtt tggagagtag gggccactca tattctgggc 1920
tcctggaacc aatcccgtga aagaattatt tttgtgtttc taaaactatg gttcccaata 1980
aaagtgactc tcagcgg                                                1997

<210> 50
<211> 622
<212> PRT
<213> Homo sapiens

<220> 
<223> thrombin precursor

<400> 50
Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala
 1               5                  10                  15      
Ala Leu Cys Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln
            20                  25                  30          
Gln Ala Arg Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu
        35                  40                  45              
Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr
    50                  55                  60                  
Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr
65                  70                  75                  80  
Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg Thr Pro
                85                  90                  95      
Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys Ala Glu Gly Leu
            100                 105                 110         
Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr Arg Ser Gly Ile Glu
        115                 120                 125             
Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn Ser
    130                 135                 140                 
Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro
145                 150                 155                 160 
Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val
                165                 170                 175     
Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr
            180                 185                 190         
Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro
        195                 200                 205             
Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg
    210                 215                 220                 
Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala
225                 230                 235                 240 
Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln
                245                 250                 255     
Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val
            260                 265                 270         
Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu
        275                 280                 285             
Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp
    290                 295                 300                 
Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr
305                 310                 315                 320 
Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys
                325                 330                 335     
Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu
            340                 345                 350         
Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser
        355                 360                 365             
Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys
    370                 375                 380                 
Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp
385                 390                 395                 400 
Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn
                405                 410                 415     
Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr
            420                 425                 430         
Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr
        435                 440                 445             
Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala
    450                 455                 460                 
Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro
465                 470                 475                 480 
Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly
                485                 490                 495     
Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr
            500                 505                 510         
Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu
        515                 520                 525             
Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile
    530                 535                 540                 
Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg
545                 550                 555                 560 
Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser
                565                 570                 575     
Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu
            580                 585                 590         
Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg
        595                 600                 605             
Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu
    610                 615                 620         


<210> 51
<211> 579
<212> PRT
<213> Homo sapiens

<220> 
<223> Thrombin mature

<400> 51
Ala Asn Thr Phe Leu Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu
 1               5                  10                  15      
Cys Val Glu Glu Thr Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu
            20                  25                  30          
Ser Ser Thr Ala Thr Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu
        35                  40                  45              
Thr Ala Arg Thr Pro Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn
    50                  55                  60                  
Cys Ala Glu Gly Leu Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr
65                  70                  75                  80  
Arg Ser Gly Ile Glu Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys
                85                  90                  95      
Pro Glu Ile Asn Ser Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn
            100                 105                 110         
Phe Cys Arg Asn Pro Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr
        115                 120                 125             
Thr Asp Pro Thr Val Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly
    130                 135                 140                 
Gln Asp Gln Val Thr Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser
145                 150                 155                 160 
Val Asn Leu Ser Pro Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln
                165                 170                 175     
Gln Tyr Gln Gly Arg Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu
            180                 185                 190         
Ala Trp Ala Ser Ala Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe
        195                 200                 205             
Asn Ser Ala Val Gln Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly
    210                 215                 220                 
Asp Glu Glu Gly Val Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe
225                 230                 235                 240 
Gly Tyr Cys Asp Leu Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr
                245                 250                 255     
Gly Asp Gly Leu Asp Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr
            260                 265                 270         
Ala Thr Ser Glu Tyr Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser
        275                 280                 285             
Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu
    290                 295                 300                 
Glu Asp Lys Thr Glu Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg
305                 310                 315                 320 
Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val
                325                 330                 335     
Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu
            340                 345                 350         
Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro
        355                 360                 365             
Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly
    370                 375                 380                 
Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met
385                 390                 395                 400 
Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu
                405                 410                 415     
Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser
            420                 425                 430         
Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser
        435                 440                 445             
Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu
    450                 455                 460                 
Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu
465                 470                 475                 480 
Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser
                485                 490                 495     
Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro
            500                 505                 510         
Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro
        515                 520                 525             
Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile
    530                 535                 540                 
Val Ser Trp Gly Glu Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr
545                 550                 555                 560 
Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln
                565                 570                 575     
Phe Gly Glu
            


<210> 52
<211> 955
<212> DNA
<213> Homo sapiens

<220> 
<223> Granzyme B precursor

<400> 52
ccaagagcta aaagagagta agggggaaac aacagcagct ccaaccaggg cagccttcct 60
gagaagatgc aaccaatcct gcttctgctg gccttcctcc tgctgcccag ggcagatgca 120
ggggagatca tcgggggaca tgaggccaag ccccactccc gcccctacat ggcttatctt 180
atgatctggg atcagaagtc tctgaagagg tgcggtggct tcctgataca agacgacttc 240
gtgctgacag ctgctcactg ttggggaagc tccataaatg tcaccttggg ggcccacaat 300
atcaaagaac aggagccgac ccagcagttt atccctgtga aaagacccat cccccatcca 360
gcctataatc ctaagaactt ctccaacgac atcatgctac tgcagctgga gagaaaggcc 420
aagcggacca gagctgtgca gcccctcagg ctacctagca acaaggccca ggtgaagcca 480
gggcagacat gcagtgtggc cggctggggg cagacggccc ccctgggaaa acactcacac 540
acactacaag aggtgaagat gacagtgcag gaagatcgaa agtgcgaatc tgacttacgc 600
cattattacg acagtaccat tgagttgtgc gtgggggacc cagagattaa aaagacttcc 660
tttaaggggg actctggagg ccctcttgtg tgtaacaagg tggcccaggg cattgtctcc 720
tatggacgaa acaatggcat gcctccacga gcctgcacca aagtctcaag ctttgtacac 780
tggataaaga aaaccatgaa acgctactaa ctacaggaag caaactaagc ccccgctgta 840
atgaaacacc ttctctggag ccaagtccag atttacactg ggagaggtgc cagcaactga 900
ataaatacct cttagctgag tggaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa      955

<210> 53
<211> 247
<212> PRT
<213> Homo sapiens

<220> 
<223> Granzyme B precursor

<400> 53
Met Gln Pro Ile Leu Leu Leu Leu Ala Phe Leu Leu Leu Pro Arg Ala
 1               5                  10                  15      
Asp Ala Gly Glu Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg
            20                  25                  30          
Pro Tyr Met Ala Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu Lys Arg
        35                  40                  45              
Cys Gly Gly Phe Leu Ile Gln Asp Asp Phe Val Leu Thr Ala Ala His
    50                  55                  60                  
Cys Trp Gly Ser Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys
65                  70                  75                  80  
Glu Gln Glu Pro Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro
                85                  90                  95      
His Pro Ala Tyr Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu
            100                 105                 110         
Gln Leu Glu Arg Lys Ala Lys Arg Thr Arg Ala Val Gln Pro Leu Arg
        115                 120                 125             
Leu Pro Ser Asn Lys Ala Gln Val Lys Pro Gly Gln Thr Cys Ser Val
    130                 135                 140                 
Ala Gly Trp Gly Gln Thr Ala Pro Leu Gly Lys His Ser His Thr Leu
145                 150                 155                 160 
Gln Glu Val Lys Met Thr Val Gln Glu Asp Arg Lys Cys Glu Ser Asp
                165                 170                 175     
Leu Arg His Tyr Tyr Asp Ser Thr Ile Glu Leu Cys Val Gly Asp Pro
            180                 185                 190         
Glu Ile Lys Lys Thr Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu Val
        195                 200                 205             
Cys Asn Lys Val Ala Gln Gly Ile Val Ser Tyr Gly Arg Asn Asn Gly
    210                 215                 220                 
Met Pro Pro Arg Ala Cys Thr Lys Val Ser Ser Phe Val His Trp Ile
225                 230                 235                 240 
Lys Lys Thr Met Lys Arg Tyr
                245         


<210> 54
<211> 227
<212> PRT
<213> Homo sapiens

<220> 
<223> Granzyme B mature
      

<400> 54
Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg Pro Tyr Met Ala
 1               5                  10                  15      
Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu Lys Arg Cys Gly Gly Phe
            20                  25                  30          
Leu Ile Gln Asp Asp Phe Val Leu Thr Ala Ala His Cys Trp Gly Ser
        35                  40                  45              
Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys Glu Gln Glu Pro
    50                  55                  60                  
Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro His Pro Ala Tyr
65                  70                  75                  80  
Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu Gln Leu Glu Arg
                85                  90                  95      
Lys Ala Lys Arg Thr Arg Ala Val Gln Pro Leu Arg Leu Pro Ser Asn
            100                 105                 110         
Lys Ala Gln Val Lys Pro Gly Gln Thr Cys Ser Val Ala Gly Trp Gly
        115                 120                 125             
Gln Thr Ala Pro Leu Gly Lys His Ser His Thr Leu Gln Glu Val Lys
    130                 135                 140                 
Met Thr Val Gln Glu Asp Arg Lys Cys Glu Ser Asp Leu Arg His Tyr
145                 150                 155                 160 
Tyr Asp Ser Thr Ile Glu Leu Cys Val Gly Asp Pro Glu Ile Lys Lys
                165                 170                 175     
Thr Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Lys Val
            180                 185                 190         
Ala Gln Gly Ile Val Ser Tyr Gly Arg Asn Asn Gly Met Pro Pro Arg
        195                 200                 205             
Ala Cys Thr Lys Val Ser Ser Phe Val His Trp Ile Lys Lys Thr Met
    210                 215                 220                 
Lys Arg Tyr
225         


<210> 55
<211> 4100
<212> DNA
<213> Homo sapiens

<220> 
<223> Cathepsin S precursor

<400> 55
gtacctcatg tgacaagttc caatttcttt tcaagtcaat tgaactgaaa tctccttgtt 60
gctttgaaat cttagaagag agcccactaa ttcaaggact cttactgtgg gagcaactgc 120
tggttctatc acaatgaaac ggctggtttg tgtgctcttg gtgtgctcct ctgcagtggc 180
acagttgcat aaagatccta ccctggatca ccactggcat ctctggaaga aaacctatgg 240
caaacaatac aaggaaaaga atgaagaagc agtacgacgt ctcatctggg aaaagaatct 300
aaagtttgtg atgcttcaca acctggagca ttcaatggga atgcactcat acgatctggg 360
catgaaccac ctgggagaca tgaccagtga agaagtgatg tctttgatga gttccctgag 420
agttcccagc cagtggcaga gaaatatcac atataagtca aaccctaatc ggatattgcc 480
tgattctgtg gactggagag agaaagggtg tgttactgaa gtgaaatatc aaggttcttg 540
tggtgcttgc tgggctttca gtgctgtggg ggccctggaa gcacagctga agctgaaaac 600
aggaaagctg gtgtctctca gtgcccagaa cctggtggat tgctcaactg aaaaatatgg 660
aaacaaaggc tgcaatggtg gcttcatgac aacggctttc cagtacatca ttgataacaa 720
gggcatcgac tcagacgctt cctatcccta caaagccatg gatcagaaat gtcaatatga 780
ctcaaaatat cgtgctgcca catgttcaaa gtacactgaa cttccttatg gcagagaaga 840
tgtcctgaaa gaagctgtgg ccaataaagg cccagtgtct gttggtgtag atgcgcgtca 900
tccttctttc ttcctctaca gaagtggtgt ctactatgaa ccatcctgta ctcagaatgt 960
gaatcatggt gtacttgtgg ttggctatgg tgatcttaat gggaaagaat actggcttgt 1020
gaaaaacagc tggggccaca actttggtga agaaggatat attcggatgg caagaaataa 1080
aggaaatcat tgtgggattg ctagctttcc ctcttaccca gaaatctaga ggatctctcc 1140
tttttataac aaatcaagaa atatgaagca ctttctctta acttaatttt tcctgctgta 1200
tccagaagaa ataattgtgt catgattaat gtgtatttac tgtactaatt agaaaatata 1260
gtttgaggcc gggcacggtg gctcacgcct gtaatcccag tacttgggag gccaaggcag 1320
gcatatcaac ttgaggccag gagttaaaga gcagcctggc taacatggtg aaaccccatc 1380
tctactaaaa atacaaaaaa ttagccgagc acggtggtgc atgcctgtaa tcccagctac 1440
ttgggaggct gaggcacgag attccttgaa cccaagaggt tgaggctatg ttgagctgag 1500
atcacaccac tgtactccag cctggatgac agagtggaga ctctgtttca aaaaaacaga 1560
aaagaaaata tagtttgatt cttcattttt ttaaatttgc aaatctcagg ataaagtttg 1620
ctaagtaaat tagtaatgta ctatagatat aactgtacaa aaattgttca acctaaaaca 1680
atctgtaatt gcttattgtt ttattgtata ctctttgtct ttttaagacc cctaatagcc 1740
ttttgtaact tgatggctta aaaatactta ataaatctgc catttcaaat ttctatcatt 1800
gccacatacc attcttattc ctaggcaact attaataatc tatcctgaga atattaattg 1860
tggtattctg gtgatggggt ttagcaactt tgatggaaga aaatattagg ctataaatgt 1920
cctaaggact cagattgtat ctttgtacag aagaggattc aaaacgccac gtgtagtggc 1980
tcatgcctgt aatcccaaca ctttgggagg ctgaagtagg aggatcgtct tgagcccagg 2040
agttcaagac cagcctggac aacatagtga gaccttgtct ccacaaaaat aaaaaagaaa 2100
ctatccagga gtggtggtgt gtgcctgtgg tccctgctat gcagatgtct aagacaggag 2160
gatcacaaga gcccaggagg ttgagaatgc agtgagcttg taattgcacc actgcactcc 2220
agcctgggtg acagagcaag accctgtctt aaaaaaagag gattcaacac atatttttat 2280
attatgttaa agtaaagaaa tgcataaaag acaagcactt tggaagaatt attttaatga 2340
tcaacaattt aatgtattag tccaaattat ttttacgtag tcatcaacaa tttgaccagg 2400
gcctttattt ggcaaataac tgagccaacc agaataaaat aaccaatact ccactgctca 2460
tatttttatc taattcagat ggatcttcct tacaactgct ctagattagt agatgcatct 2520
aagcaggcag caggaacttt aaatttttta agttcatgtc tatgacatga acaatgtgtg 2580
ggataatgtc attaatatat cctaaattaa cctaaacgta tttcactaac tctggctcct 2640
tctccataaa gcacatttta aggaacaaga attgctaaat ataaaaacat aaataatacc 2700
ataatacatg gctatcatca aaagtgtata gaatattata gtttaaaagt atttagttga 2760
ttacttttca gttttgtttt gttttttgag acggagtctc actctgttgc ccaggctgga 2820
gtgcagtggc accatctcag ttcactgcaa cttctgcctc ccgagttcaa gcgattctcc 2880
tgcctcagcc tcccgagtag ctggaattat aggcgtgcac caccacgccc agctaatttt 2940
tgtattttta gtaaagacag ggttttgcca cattagccag gctggtctca aactcctgac 3000
ctcaggtgat ccacccaccc cagcctccca aagtgctaag attacaggcg tgagccactg 3060
agcccagcct acttttcagt ttttaacata atttttgttt tatccacaac ttttcaagta 3120
ttgaaagtag aataaaaaca tgggttctta gtctttagct atctgttaaa gcctatgaat 3180
gccttcttaa aatcatgttt ttaaatgcat aaaatatata ggattacaaa ggaatctaat 3240
tatatcgaaa tacagttatt aaaatgttaa aagataagtt tgttatatat taatatgcat 3300
gcttctttat aaatgcatta aataagagtt aatagctatc ctaaatttga aatagtgata 3360
agcataatga aaatagatgc aaaaaactaa tgtgatatga aaatatctgg gtttttcttt 3420
tgatgatgaa gtattgctaa tattaccgtg gtttatgaac tatgttcaga attgaagaaa 3480
atcctaactt tcagttagag gttagtgacg gggttcagga caccctacac aaaatacagc 3540
actttgacat attgaatatt ttaagctgaa ggcatttgag gaaattgcag aagcaggaag 3600
gtgactctga ccttctgcct gctgttctcc ccagaagcag ccataaaacc tgggaaggat 3660
tttctgacct tcccctgaag tagatcataa gactgtcatg taagaggtgc tctcctggca 3720
cccagagaaa aggagcatcc ttacctccaa aagcacaggg acacaaagag gaatctaaac 3780
aaacaggcct ctcagtttcc cccagtttat tacatttagc ttgttcacac tttgccctat 3840
gacatttcta catcactggc tgctcttcat caaacctact ataaaaaaca ttcaagttca 3900
actgtttctt tgggccttta tttccttatg gagcccctcg tgtcgtgtaa aacttatatt 3960
aaataaatgt gcatgctttt ctcttgctaa tctctctttt gttatagaga tctcagccct 4020
aaacctagga tggatagaag gaaacatatg ttctccccta cattagtaaa aataaaaatg 4080
gaatttttta cccatacaaa                                             4100

<210> 56
<211> 331
<212> PRT
<213> Homo sapiens

<220> 
<223> Cathepsin S precursor

<400> 56
Met Lys Arg Leu Val Cys Val Leu Leu Val Cys Ser Ser Ala Val Ala
 1               5                  10                  15      
Gln Leu His Lys Asp Pro Thr Leu Asp His His Trp His Leu Trp Lys
            20                  25                  30          
Lys Thr Tyr Gly Lys Gln Tyr Lys Glu Lys Asn Glu Glu Ala Val Arg
        35                  40                  45              
Arg Leu Ile Trp Glu Lys Asn Leu Lys Phe Val Met Leu His Asn Leu
    50                  55                  60                  
Glu His Ser Met Gly Met His Ser Tyr Asp Leu Gly Met Asn His Leu
65                  70                  75                  80  
Gly Asp Met Thr Ser Glu Glu Val Met Ser Leu Met Ser Ser Leu Arg
                85                  90                  95      
Val Pro Ser Gln Trp Gln Arg Asn Ile Thr Tyr Lys Ser Asn Pro Asn
            100                 105                 110         
Arg Ile Leu Pro Asp Ser Val Asp Trp Arg Glu Lys Gly Cys Val Thr
        115                 120                 125             
Glu Val Lys Tyr Gln Gly Ser Cys Gly Ala Cys Trp Ala Phe Ser Ala
    130                 135                 140                 
Val Gly Ala Leu Glu Ala Gln Leu Lys Leu Lys Thr Gly Lys Leu Val
145                 150                 155                 160 
Ser Leu Ser Ala Gln Asn Leu Val Asp Cys Ser Thr Glu Lys Tyr Gly
                165                 170                 175     
Asn Lys Gly Cys Asn Gly Gly Phe Met Thr Thr Ala Phe Gln Tyr Ile
            180                 185                 190         
Ile Asp Asn Lys Gly Ile Asp Ser Asp Ala Ser Tyr Pro Tyr Lys Ala
        195                 200                 205             
Met Asp Gln Lys Cys Gln Tyr Asp Ser Lys Tyr Arg Ala Ala Thr Cys
    210                 215                 220                 
Ser Lys Tyr Thr Glu Leu Pro Tyr Gly Arg Glu Asp Val Leu Lys Glu
225                 230                 235                 240 
Ala Val Ala Asn Lys Gly Pro Val Ser Val Gly Val Asp Ala Arg His
                245                 250                 255     
Pro Ser Phe Phe Leu Tyr Arg Ser Gly Val Tyr Tyr Glu Pro Ser Cys
            260                 265                 270         
Thr Gln Asn Val Asn His Gly Val Leu Val Val Gly Tyr Gly Asp Leu
        275                 280                 285             
Asn Gly Lys Glu Tyr Trp Leu Val Lys Asn Ser Trp Gly His Asn Phe
    290                 295                 300                 
Gly Glu Glu Gly Tyr Ile Arg Met Ala Arg Asn Lys Gly Asn His Cys
305                 310                 315                 320 
Gly Ile Ala Ser Phe Pro Ser Tyr Pro Glu Ile
                325                 330     


<210> 57
<211> 217
<212> PRT
<213> Homo sapiens

<220> 
<223> Cathepsin S mature

<400> 57
Leu Pro Asp Ser Val Asp Trp Arg Glu Lys Gly Cys Val Thr Glu Val
 1               5                  10                  15      
Lys Tyr Gln Gly Ser Cys Gly Ala Cys Trp Ala Phe Ser Ala Val Gly
            20                  25                  30          
Ala Leu Glu Ala Gln Leu Lys Leu Lys Thr Gly Lys Leu Val Ser Leu
        35                  40                  45              
Ser Ala Gln Asn Leu Val Asp Cys Ser Thr Glu Lys Tyr Gly Asn Lys
    50                  55                  60                  
Gly Cys Asn Gly Gly Phe Met Thr Thr Ala Phe Gln Tyr Ile Ile Asp
65                  70                  75                  80  
Asn Lys Gly Ile Asp Ser Asp Ala Ser Tyr Pro Tyr Lys Ala Met Asp
                85                  90                  95      
Gln Lys Cys Gln Tyr Asp Ser Lys Tyr Arg Ala Ala Thr Cys Ser Lys
            100                 105                 110         
Tyr Thr Glu Leu Pro Tyr Gly Arg Glu Asp Val Leu Lys Glu Ala Val
        115                 120                 125             
Ala Asn Lys Gly Pro Val Ser Val Gly Val Asp Ala Arg His Pro Ser
    130                 135                 140                 
Phe Phe Leu Tyr Arg Ser Gly Val Tyr Tyr Glu Pro Ser Cys Thr Gln
145                 150                 155                 160 
Asn Val Asn His Gly Val Leu Val Val Gly Tyr Gly Asp Leu Asn Gly
                165                 170                 175     
Lys Glu Tyr Trp Leu Val Lys Asn Ser Trp Gly His Asn Phe Gly Glu
            180                 185                 190         
Glu Gly Tyr Ile Arg Met Ala Arg Asn Lys Gly Asn His Cys Gly Ile
        195                 200                 205             
Ala Ser Phe Pro Ser Tyr Pro Glu Ile
    210                 215         


<210> 58
<211> 1702
<212> DNA
<213> Homo sapiens

<220> 
<223> Cathepsin K precursor

<400> 58
aaattttcca gccgatcact ggagctgact tccgcaatcc cgatggaata aatctagcac 60
ccctgatggt gtgcccacac tttgctgccg aaacgaagcc agacaacaga tttccatcag 120
caggatgtgg gggctcaagg ttctgctgct acctgtggtg agctttgctc tgtaccctga 180
ggagatactg gacacccact gggagctatg gaagaagacc cacaggaagc aatataacaa 240
caaggtggat gaaatctctc ggcgtttaat ttgggaaaaa aacctgaagt atatttccat 300
ccataacctt gaggcttctc ttggtgtcca tacatatgaa ctggctatga accacctggg 360
ggacatgacc agtgaagagg tggttcagaa gatgactgga ctcaaagtac ccctgtctca 420
ttcccgcagt aatgacaccc tttatatccc agaatgggaa ggtagagccc cagactctgt 480
cgactatcga aagaaaggat atgttactcc tgtcaaaaat cagggtcagt gtggttcctg 540
ttgggctttt agctctgtgg gtgccctgga gggccaactc aagaagaaaa ctggcaaact 600
cttaaatctg agtccccaga acctagtgga ttgtgtgtct gagaatgatg gctgtggagg 660
gggctacatg accaatgcct tccaatatgt gcagaagaac cggggtattg actctgaaga 720
tgcctaccca tatgtgggac aggaagagag ttgtatgtac aacccaacag gcaaggcagc 780
taaatgcaga gggtacagag agatccccga ggggaatgag aaagccctga agagggcagt 840
ggcccgagtg ggacctgtct ctgtggccat tgatgcaagc ctgacctcct tccagtttta 900
cagcaaaggt gtgtattatg atgaaagctg caatagcgat aatctgaacc atgcggtttt 960
ggcagtggga tatggaatcc agaagggaaa caagcactgg ataattaaaa acagctgggg 1020
agaaaactgg ggaaacaaag gatatatcct catggctcga aataagaaca acgcctgtgg 1080
cattgccaac ctggccagct tccccaagat gtgactccag ccagccaaat ccatcctgct 1140
cttccatttc ttccacgatg gtgcagtgta acgatgcact ttggaaggga gttggtgtgc 1200
tatttttgaa gcagatgtgg tgatactgag attgtctgtt cagtttcccc atttgtttgt 1260
gcttcaaatg atccttccta ctttgcttct ctccacccat gacctttttc actgtggcca 1320
tcaggacttt ccctgacagc tgtgtactct taggctaaga gatgtgacta cagcctgccc 1380
ctgactgtgt tgtcccaggg ctgatgctgt acaggtacag gctggagatt ttcacatagg 1440
ttagattctc attcacggga ctagttagct ttaagcaccc tagaggacta gggtaatctg 1500
acttctcact tcctaagttc ccttctatat cctcaaggta gaaatgtcta tgttttctac 1560
tccaattcat aaatctattc ataagtcttt ggtacaagtt tacatgataa aaagaaatgt 1620
gatttgtctt cccttctttg cacttttgaa ataaagtatt tatctcctgt ctacagttta 1680
ataaatagca tctagtacac at                                          1702

<210> 59
<211> 329
<212> PRT
<213> Homo sapiens

<220> 
<223> Cathepsin K precursor

<400> 59
Met Trp Gly Leu Lys Val Leu Leu Leu Pro Val Val Ser Phe Ala Leu
 1               5                  10                  15      
Tyr Pro Glu Glu Ile Leu Asp Thr His Trp Glu Leu Trp Lys Lys Thr
            20                  25                  30          
His Arg Lys Gln Tyr Asn Asn Lys Val Asp Glu Ile Ser Arg Arg Leu
        35                  40                  45              
Ile Trp Glu Lys Asn Leu Lys Tyr Ile Ser Ile His Asn Leu Glu Ala
    50                  55                  60                  
Ser Leu Gly Val His Thr Tyr Glu Leu Ala Met Asn His Leu Gly Asp
65                  70                  75                  80  
Met Thr Ser Glu Glu Val Val Gln Lys Met Thr Gly Leu Lys Val Pro
                85                  90                  95      
Leu Ser His Ser Arg Ser Asn Asp Thr Leu Tyr Ile Pro Glu Trp Glu
            100                 105                 110         
Gly Arg Ala Pro Asp Ser Val Asp Tyr Arg Lys Lys Gly Tyr Val Thr
        115                 120                 125             
Pro Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ser
    130                 135                 140                 
Val Gly Ala Leu Glu Gly Gln Leu Lys Lys Lys Thr Gly Lys Leu Leu
145                 150                 155                 160 
Asn Leu Ser Pro Gln Asn Leu Val Asp Cys Val Ser Glu Asn Asp Gly
                165                 170                 175     
Cys Gly Gly Gly Tyr Met Thr Asn Ala Phe Gln Tyr Val Gln Lys Asn
            180                 185                 190         
Arg Gly Ile Asp Ser Glu Asp Ala Tyr Pro Tyr Val Gly Gln Glu Glu
        195                 200                 205             
Ser Cys Met Tyr Asn Pro Thr Gly Lys Ala Ala Lys Cys Arg Gly Tyr
    210                 215                 220                 
Arg Glu Ile Pro Glu Gly Asn Glu Lys Ala Leu Lys Arg Ala Val Ala
225                 230                 235                 240 
Arg Val Gly Pro Val Ser Val Ala Ile Asp Ala Ser Leu Thr Ser Phe
                245                 250                 255     
Gln Phe Tyr Ser Lys Gly Val Tyr Tyr Asp Glu Ser Cys Asn Ser Asp

            260                 265                 270         
Asn Leu Asn His Ala Val Leu Ala Val Gly Tyr Gly Ile Gln Lys Gly
        275                 280                 285             
Asn Lys His Trp Ile Ile Lys Asn Ser Trp Gly Glu Asn Trp Gly Asn
    290                 295                 300                 
Lys Gly Tyr Ile Leu Met Ala Arg Asn Lys Asn Asn Ala Cys Gly Ile
305                 310                 315                 320 
Ala Asn Leu Ala Ser Phe Pro Lys Met
                325                 


<210> 60
<211> 215
<212> PRT
<213> Homo sapiens

<220> 
<223> Cathepsin K mature
      

<400> 60
Ala Pro Asp Ser Val Asp Tyr Arg Lys Lys Gly Tyr Val Thr Pro Val
 1               5                  10                  15      
Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ser Val Gly
            20                  25                  30          
Ala Leu Glu Gly Gln Leu Lys Lys Lys Thr Gly Lys Leu Leu Asn Leu
        35                  40                  45              
Ser Pro Gln Asn Leu Val Asp Cys Val Ser Glu Asn Asp Gly Cys Gly
    50                  55                  60                  
Gly Gly Tyr Met Thr Asn Ala Phe Gln Tyr Val Gln Lys Asn Arg Gly
65                  70                  75                  80  
Ile Asp Ser Glu Asp Ala Tyr Pro Tyr Val Gly Gln Glu Glu Ser Cys
                85                  90                  95      
Met Tyr Asn Pro Thr Gly Lys Ala Ala Lys Cys Arg Gly Tyr Arg Glu
            100                 105                 110         
Ile Pro Glu Gly Asn Glu Lys Ala Leu Lys Arg Ala Val Ala Arg Val
        115                 120                 125             
Gly Pro Val Ser Val Ala Ile Asp Ala Ser Leu Thr Ser Phe Gln Phe
    130                 135                 140                 
Tyr Ser Lys Gly Val Tyr Tyr Asp Glu Ser Cys Asn Ser Asp Asn Leu
145                 150                 155                 160 
Asn His Ala Val Leu Ala Val Gly Tyr Gly Ile Gln Lys Gly Asn Lys
                165                 170                 175     
His Trp Ile Ile Lys Asn Ser Trp Gly Glu Asn Trp Gly Asn Lys Gly
            180                 185                 190         
Tyr Ile Leu Met Ala Arg Asn Lys Asn Asn Ala Cys Gly Ile Ala Asn
        195                 200                 205             
Leu Ala Ser Phe Pro Lys Met
    210                 215 


<210> 61
<211> 1731
<212> DNA
<213> Homo sapiens

<220> 
<223> Cathepsin L precursor

<400> 61
ggcggtgccg gccgaaccca gacccgaggt tttagaagca gagtcaggcg aagctgggcc 60
agaaccgcga cctccgcaac cttgagcggc atccgtggag tgcgcctgcg cagctacgac 120
cgcagcagga aagcgccgcc ggccaggccc agctgtggcc ggacagggac tggaagagag 180
gacgcggtcg agtaggtgtg caccagccct ggcaacgaga gcgtctaccc cgaactctgc 240
tggccttgag gtggggaagc cggggagggc agttgaggac cccgcggagg cgcgtgactg 300
gttgagcggg caggccagcc tccgagccgg gtggacacag ttttaaaaca tgaatcctac 360
actcatcctt gctgcctttt gcctgggaat tgcctcagct actctaacat ttgatcacag 420
tttagaggca cagtggacca agtggaaggc gatgcacaac agattatacg gcatgaatga 480
agaaggatgg aggagagcag tgtgggagaa gaacatgaag atgattgaac tgcacaatca 540
ggaatacagg gaagggaaac acagcttcac aatggccatg aacgcctttg gagacatgac 600
cagtgaagaa ttcaggcagg tgatgaatgg ctttcaaaac cgtaagccca ggaaggggaa 660
agtgttccag gaacctctgt tttatgaggc ccccagatct gtggattgga gagagaaagg 720
ctacgtgact cctgtgaaga atcagggtca gtgtggttct tgttgggctt ttagtgctac 780
tggtgctctt gaaggacaga tgttccggaa aactgggagg cttatctcac tgagtgagca 840
gaatctggta gactgctctg ggcctcaagg caatgaaggc tgcaatggtg gcctaatgga 900
ttatgctttc cagtatgttc aggataatgg aggcctggac tctgaggaat cctatccata 960
tgaggcaaca gaagaatcct gtaagtacaa tcccaagtat tctgttgcta atgacaccgg 1020
ctttgtggac atccctaagc aggagaaggc cctgatgaag gcagttgcaa ctgtggggcc 1080
catttctgtt gctattgatg caggtcatga gtccttcctg ttctataaag aaggcattta 1140
ttttgagcca gactgtagca gtgaagacat ggatcatggt gtgctggtgg ttggctacgg 1200
atttgaaagc acagaatcag ataacaataa atattggctg gtgaagaaca gctggggtga 1260
agaatggggc atgggtggct acgtaaagat ggccaaagac cggagaaacc attgtggaat 1320
tgcctcagca gccagctacc ccactgtgtg agctggtgga cggtgatgag gaaggacttg 1380
actggggatg gcgcatgcat gggaggaatt catcttcagt ctaccagccc ccgctgtgtc 1440
ggatacacac tcgaatcatt gaagatccga gtgtgatttg aattctgtga tattttcaca 1500
ctggtaaatg ttacctctat tttaattact gctataaata ggtttatatt attgattcac 1560
ttactgactt tgcattttcg tttttaaaag gatgtataaa tttttacctg tttaaataaa 1620
atttaatttc aaatgtagtg gtggggcttc tttctatttt tgatgcactg aatttttgtg 1680
taataaagaa cataattggg ctctaagcca taaaaaaaaa aaaaaaaaaa a          1731

<210> 62
<211> 333
<212> PRT
<213> Homo sapiens

<220> 
<223> Cathepsin L precursor

<400> 62
Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser
 1               5                  10                  15      
Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp
            20                  25                  30          
Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg
        35                  40                  45              
Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln
    50                  55                  60                  
Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe
65                  70                  75                  80  
Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln
                85                  90                  95      
Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr
            100                 105                 110         
Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro
        115                 120                 125             
Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr
    130                 135                 140                 
Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser
145                 150                 155                 160 
Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu
                165                 170                 175     
Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp
            180                 185                 190         
Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu
        195                 200                 205             
Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly
    210                 215                 220                 
Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala
225                 230                 235                 240 
Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe
                245                 250                 255     
Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu
            260                 265                 270         
Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr
        275                 280                 285             
Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu
    290                 295                 300                 
Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn
305                 310                 315                 320 
His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val
                325                 330             


<210> 63
<211> 3783
<212> DNA
<213> Homo sapiens

<220> 
<223> Cathepsin B precursor

<400> 63
ggggcggggc cgggagggta cttagggccg gggctggccc aggctacggc ggctgcaggg 60
ctccggcaac cgctccggca acgccaaccg ctccgctgcg cgcaggctgg gctgcaggct 120
ctcggctgca gcgctgggtg gatctaggat ccggcttcca acatgtggca gctctgggcc 180
tccctctgct gcctgctggt gttggccaat gcccggagca ggccctcttt ccatcccctg 240
tcggatgagc tggtcaacta tgtcaacaaa cggaatacca cgtggcaggc cgggcacaac 300
ttctacaacg tggacatgag ctacttgaag aggctatgtg gtaccttcct gggtgggccc 360
aagccacccc agagagttat gtttaccgag gacctgaagc tgcctgcaag cttcgatgca 420
cgggaacaat ggccacagtg tcccaccatc aaagagatca gagaccaggg ctcctgtggc 480
tcctgctggg ccttcggggc tgtggaagcc atctctgacc ggatctgcat ccacaccaat 540
gcgcacgtca gcgtggaggt gtcggcggag gacctgctca catgctgtgg cagcatgtgt 600
ggggacggct gtaatggtgg ctatcctgct gaagcttgga acttctggac aagaaaaggc 660
ctggtttctg gtggcctcta tgaatcccat gtagggtgca gaccgtactc catccctccc 720
tgtgagcacc acgtcaacgg ctcccggccc ccatgcacgg gggagggaga tacccccaag 780
tgtagcaaga tctgtgagcc tggctacagc ccgacctaca aacaggacaa gcactacgga 840
tacaattcct acagcgtctc caatagcgag aaggacatca tggccgagat ctacaaaaac 900
ggccccgtgg agggagcttt ctctgtgtat tcggacttcc tgctctacaa gtcaggagtg 960
taccaacacg tcaccggaga gatgatgggt ggccatgcca tccgcatcct gggctgggga 1020
gtggagaatg gcacacccta ctggctggtt gccaactcct ggaacactga ctggggtgac 1080
aatggcttct ttaaaatact cagaggacag gatcactgtg gaatcgaatc agaagtggtg 1140
gctggaattc cacgcaccga tcagtactgg gaaaagatct aatctgccgt gggcctgtcg 1200
tgccagtcct gggggcgaga tcggggtaga aatgcatttt attctttaag ttcacgtaag 1260
atacaagttt cagacagggt ctgaaggact ggattggcca aacatcagac ctgtcttcca 1320
aggagaccaa gtcctggcta catcccagcc tgtggttaca gtgcagacag gccatgtgag 1380
ccaccgctgc cagcacagag cgtccttccc cctgtagact agtgccgtag ggagtacctg 1440
ctgccccagc tgactgtggc cccctccgtg atccatccat ctccagggag caagacagag 1500
acgcaggaat ggaaagcgga gttcctaaca ggatgaaagt tcccccatca gttcccccag 1560
tacctccaag caagtagctt tccacatttg tcacagaaat cagaggagag acggtgttgg 1620
gagccctttg gagaacgcca gtctcccagg ccccctgcat ctatcgagtt tgcaatgtca 1680
caacctctct gatcttgtgc tcagcatgat tctttaatag aagttttatt ttttcgtgca 1740
ctctgctaat catgtgggtg agccagtgga acagcgggag acctgtgcta gttttacaga 1800
ttgcctcctt atgacgcggc tcaaaaggaa accaagtggt caggagttgt ttctgaccca 1860
ctgatctcta ctaccacaag gaaaatagtt taggagaaac cagcttttac tgtttttgaa 1920
aaattacagc ttcaccctgt caagttaaca aggaatgcct gtgccaataa aagttttctc 1980
caacttgaag tctactctga tgggatctca gatcctttgt cactgcctat agacttgtag 2040
ctgctgtctc tctttgtccc tgcagagaat cacgtcctgg aactgcatgt tcttgcgact 2100
cttgggactt catcttaact tctcgctgcc ccagccatgt tttcaaccat ggcatccctc 2160
ccccaattag ttccctgtca tcctcgtcaa ccttctctgt aagtgcctgg taagcttgcc 2220
cttgcttaag aactcaaaac atagctgtgc tctatttttt tgttgttgtt gtgactgaca 2280
gagtgagatt ccgtctccca ggctggagtg cagtggcgcc ttctcagctc actgcaacct 2340
gcagcctcct agattcaagc gattctcctg cttcagcctt ccgagtagct gggatgacag 2400
gcactcacca atatgcctgg gtaatttttg tatttttaag tacatacagg atttcaccat 2460
gttggccagg ctagtttcaa actcccggcc tcaggtggtc tgcctgcctc agcctcccaa 2520
agtgttggga ttacaggcgt gagccactgg gccctgcctg tattttttat cagccacaaa 2580
tccagcaaca agctgaggat tcagctcata aaacaggctt ggtgtcttgg tgatctcaca 2640
taaccaagat gctaccccgt ggggaaccac atccccctgg atgccctcca gccttggttt 2700
gggctggagt cagggcctgt atacagtatt ttgaatttgt atgccactgg tttgcattgc 2760
tggtcaggaa ctctagtgct ttgcatagcc ctggtttaga aacatgttat agcagttctt 2820
ggtatagagc aaactagaag aaccagcaat cattccactg tcctgccaag gtacacctca 2880
gtactcccct tcccaactga agtggtatga ggctagctct ttccaaaagc attcaagttt 2940
ggcttctgat gtgactcaga atttaggaac cagatgctag atcaaataag ctctgaaaat 3000
ctgaggaaca ttgtaggaaa ggtttgttaa gcatctctta agtgccatga tgagcataac 3060
agccggccgt cgtggctcac gcctgtaatc ccagcacttt gggaggccaa ggtgggagga 3120
tgacaaggtc aggagttcaa gaccagcctg gccaacatgc tgaaacctca cctctactaa 3180
aaatacaaaa attagctggg catggtggca catgcctgta atcccagcta cttgggaggc 3240
tgaggcagga gaatcgcttg aacccgggag gcggaggttg cagtgagcca agacagtgcc 3300
agtgcactcc agcctcggtg acagcgcaag gctccgtctc aataattaaa aaaaaaaaaa 3360
aaaaaaaaaa ggccgggcgc agtggctcaa gcctgtaatc ccagcacttt gggaggctga 3420
ggcgggcaga tcacctgagg tcaggagttt tgagatcagc cttggcaaca cggtgaaacc 3480
ccatctctac taaaaataca aaattagcca agcatgctgg cacatgcctg taatcccagc 3540
tactcgggag gctgaggtac gagaatcgct tgaacctggg aggcagagga tgcagtgagc 3600
cgagatcacg ccattgcact ccagcctggg ggacaagagt gaatctgtgt ctcaccaaaa 3660
aaaaaaagaa aaagaaagat gcttaacaaa ggttaccata agccacaaat tcataaccac 3720
ttatccttcc agtttcaagt agaatatatt cataacctca ataaagttct ccctgctccc 3780
aaa                                                               3783

<210> 64
<211> 339
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin B precursor

<400> 64
Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn

 1               5                  10                  15      
Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn
            20                  25                  30          
Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr
        35                  40                  45              
Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly
    50                  55                  60                  
Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu
65                  70                  75                  80  
Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile
                85                  90                  95      
Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly
            100                 105                 110         
Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His
        115                 120                 125             
Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser
    130                 135                 140                 
Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn
145                 150                 155                 160 
Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His
                165                 170                 175     
Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn
            180                 185                 190         
Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser
        195                 200                 205             
Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His
    210                 215                 220                 
Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met
225                 230                 235                 240 
Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr
                245                 250                 255     
Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly
            260                 265                 270         
Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu
        275                 280                 285             
Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp
    290                 295                 300                 
Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly
305                 310                 315                 320 
Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp
                325                 330                 335     
Glu Lys Ile
            


<210> 65
<211> 260
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin B mature

<220> 
<223> cathepsin B light chain 1-47

<220> 
<223> cathepsin B heavy chain 48-254

<400> 65
Leu Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr
 1               5                  10                  15      
Ile Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe
            20                  25                  30          
Gly Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala
        35                  40                  45              
His Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly
    50                  55                  60                  
Ser Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp
65                  70                  75                  80  
Asn Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser
                85                  90                  95      
His Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val
            100                 105                 110         
Asn Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys
        115                 120                 125             
Ser Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys
    130                 135                 140                 
His Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile
145                 150                 155                 160 
Met Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val
                165                 170                 175     

Tyr Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr
            180                 185                 190         
Gly Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val
        195                 200                 205             
Glu Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp
    210                 215                 220                 
Trp Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys
225                 230                 235                 240 
Gly Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr
                245                 250                 255     
Trp Glu Lys Ile
            260 


<210> 66
<211> 1399
<212> DNA
<213> Homo sapiens

<220> 
<223> cathepsin H precursor

<400> 66
ttgccggcgc aagagccaag ccgccagcgc tgctatgtgg gccacgctgc cgctgctctg 60
cgccggggcc tggctcctgg gagtccccgt ctgcggtgcc gccgaactgt ccgtgaactc 120
cttagagaag tttcacttca agtcatggat gtctaagcac cgtaagacct acagtacgga 180
ggagtaccac cacaggctgc agacgtttgc cagcaactgg aggaagataa acgcccacaa 240
caatgggaac cacacattta aaatggcact gaaccaattt tcagacatga gctttgctga 300
aataaaacac aagtatctct ggtcagagcc tcagaattgc tcagccacca aaagtaacta 360
ccttcgaggt actggtccct acccaccttc cgtggactgg cggaaaaaag gaaattttgt 420
ctcacctgtg aaaaatcagg gtgcctgcgg cagttgctgg actttctcca ccactggggc 480
cctggagtct gcaatcgcca tcgcaaccgg aaagatgctg tccttggcgg aacagcagct 540
ggtggactgc gcccaggact tcaataatta cggctgccaa gggggtctcc ccagccaggc 600
tttcgagtat atcctgtaca acaaggggat catgggtgaa gacacctacc cctaccaggg 660
caaggatggt tattgcaagt tccaacctgg aaaggccatc ggctttgtca aggatgtagc 720
caacatcaca atctatgacg aggaagcgat ggtggaggct gtggccctct acaaccctgt 780
gagctttgcc tttgaggtga ctcaggactt catgatgtat agaacgggca tctactccag 840
tacttcctgc cataaaactc cagataaagt aaaccatgca gtactggctg ttgggtatgg 900
agaaaaaaat gggatccctt actggatcgt gaaaaactct tggggtcccc agtggggaat 960
gaacgggtac ttcctcatcg agcgcggaaa gaacatgtgt ggcctggctg cctgcgcctc 1020
ctaccccatc cctctggtgt gagccgtggc agccgcagcg cagactggcg gagaaggaga 1080
ggaacgggca gcctgggcct gggtggaaat cctgccctgg aggaagttgt ggggagatcc 1140
actgggaccc ccaacattct gccctcacct ctgtgcccag cctggaaacc tacagacaag 1200
gaggagttcc accatgagct cacccgtgtc tatgacgcaa agatcaccag ccatgtgcct 1260
tagtgtcctt cttaacagac tcaaaccaca tggaccacga atattctttc tgtccagaag 1320
ggctactttc cacatataga gctccaggga ctgtcttttc tgtattcgct gttcaataaa 1380
cattgagtga gcacctcca                                              1399

<210> 67
<211> 335
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin H precursor

<400> 67
Met Trp Ala Thr Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly
 1               5                  10                  15      
Val Pro Val Cys Gly Ala Ala Glu Leu Ser Val Asn Ser Leu Glu Lys
            20                  25                  30          
Phe His Phe Lys Ser Trp Met Ser Lys His Arg Lys Thr Tyr Ser Thr
        35                  40                  45              
Glu Glu Tyr His His Arg Leu Gln Thr Phe Ala Ser Asn Trp Arg Lys

    50                  55                  60                  
Ile Asn Ala His Asn Asn Gly Asn His Thr Phe Lys Met Ala Leu Asn
65                  70                  75                  80  
Gln Phe Ser Asp Met Ser Phe Ala Glu Ile Lys His Lys Tyr Leu Trp
                85                  90                  95      
Ser Glu Pro Gln Asn Cys Ser Ala Thr Lys Ser Asn Tyr Leu Arg Gly
            100                 105                 110         
Thr Gly Pro Tyr Pro Pro Ser Val Asp Trp Arg Lys Lys Gly Asn Phe
        115                 120                 125             
Val Ser Pro Val Lys Asn Gln Gly Ala Cys Gly Ser Cys Trp Thr Phe
    130                 135                 140                 
Ser Thr Thr Gly Ala Leu Glu Ser Ala Ile Ala Ile Ala Thr Gly Lys
145                 150                 155                 160 
Met Leu Ser Leu Ala Glu Gln Gln Leu Val Asp Cys Ala Gln Asp Phe
                165                 170                 175     
Asn Asn His Gly Cys Gln Gly Gly Leu Pro Ser Gln Ala Phe Glu Tyr
            180                 185                 190         
Ile Leu Tyr Asn Lys Gly Ile Met Gly Glu Asp Thr Tyr Pro Tyr Gln
        195                 200                 205             
Gly Lys Asp Gly Tyr Cys Lys Phe Gln Pro Gly Lys Ala Ile Gly Phe
    210                 215                 220                 
Val Lys Asp Val Ala Asn Ile Thr Ile Tyr Asp Glu Glu Ala Met Val
225                 230                 235                 240 
Glu Ala Val Ala Leu Tyr Asn Pro Val Ser Phe Ala Phe Glu Val Thr
                245                 250                 255     
Gln Asp Phe Met Met Tyr Arg Thr Gly Ile Tyr Ser Ser Thr Ser Cys
            260                 265                 270         
His Lys Thr Pro Asp Lys Val Asn His Ala Val Leu Ala Val Gly Tyr
        275                 280                 285             
Gly Glu Lys Asn Gly Ile Pro Tyr Trp Ile Val Lys Asn Ser Trp Gly
    290                 295                 300                 
Pro Gln Trp Gly Met Asn Gly Tyr Phe Leu Ile Glu Arg Gly Lys Asn
305                 310                 315                 320 
Met Cys Gly Leu Ala Ala Cys Ala Ser Tyr Pro Ile Pro Leu Val
                325                 330                 335 


<210> 68
<211> 238
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin H mature

<400> 68
Glu Pro Gln Asn Cys Ser Ala Thr Lys Ser Asn Tyr Leu Arg Gly Thr
 1               5                  10                  15      
Gly Pro Tyr Pro Pro Ser Val Asp Trp Arg Lys Lys Gly Asn Phe Val
            20                  25                  30          
Ser Pro Val Lys Asn Gln Gly Ala Cys Gly Ser Cys Trp Thr Phe Ser
        35                  40                  45              
Thr Thr Gly Ala Leu Glu Ser Ala Ile Ala Ile Ala Thr Gly Lys Met
    50                  55                  60                  
Leu Ser Leu Ala Glu Gln Gln Leu Val Asp Cys Ala Gln Asp Phe Asn
65                  70                  75                  80  
Asn His Gly Cys Gln Gly Gly Leu Pro Ser Gln Ala Phe Glu Tyr Ile
                85                  90                  95      
Leu Tyr Asn Lys Gly Ile Met Gly Glu Asp Thr Tyr Pro Tyr Gln Gly
            100                 105                 110         
Lys Asp Gly Tyr Cys Lys Phe Gln Pro Gly Lys Ala Ile Gly Phe Val
        115                 120                 125             
Lys Asp Val Ala Asn Ile Thr Ile Tyr Asp Glu Glu Ala Met Val Glu
    130                 135                 140                 
Ala Val Ala Leu Tyr Asn Pro Val Ser Phe Ala Phe Glu Val Thr Gln
145                 150                 155                 160 
Asp Phe Met Met Tyr Arg Thr Gly Ile Tyr Ser Ser Thr Ser Cys His
                165                 170                 175     
Lys Thr Pro Asp Lys Val Asn His Ala Val Leu Ala Val Gly Tyr Gly
            180                 185                 190         
Glu Lys Asn Gly Ile Pro Tyr Trp Ile Val Lys Asn Ser Trp Gly Pro
        195                 200                 205             
Gln Trp Gly Met Asn Gly Tyr Phe Leu Ile Glu Arg Gly Lys Asn Met
    210                 215                 220                 
Cys Gly Leu Ala Ala Cys Ala Ser Tyr Pro Ile Pro Leu Val
225                 230                 235             


<210> 69

<211> 1975
<212> DNA
<213> Mus musculus

<220> 
<223> cathepsin F precursor

<400> 69
cggtgcccat tggccgcccc ggcgttctcc aacgttgtag ggaaactctc tgtggcctct 60
gacagcaggc tccgcctcgg gtctcttgat ccgtgtgttt gtgggtcagt gaatccgggc 120
gagcagcttc gacctcgcta tggcgcccct actgcagctt ctgtggctgc tgacactgct 180
ctcgactgtg gccctgagcc ccgtccccgc caagccctgg gcagatgacg agcaggcctg 240
gaacttgtcg tcccaggagc tgctggcccc cgcccgcttc gcgctggaca tgtacaatta 300
cggccgtgct gcggggacaa gggccgtgct aggagcggtg cgcggacgcg tccgccgggc 360
cggccagggc tctctgttct ccctggaagc cacactagag gagccacctt gcaatgatcc 420
cctggtgtgc ccactgcctg agacgaagaa aacagtgctc tgcagttttg aagtcctgga 480
agagctaaaa gaacacttgc tgctgaggag ggactgtagc ccagtgaatg ccaaggtcac 540
agagtttaga aatgcgactt tcagctcatt ccttccattg ttggacaagg atcccctgcc 600
ccaggacttc tctgtgaaga tggctccact cttcaaggac ttcatgacca cctataaccg 660
gacttatgaa tcaagggaag aagcccagtg gcgattgact gtctttgcaa gaaatatgat 720
acgagcacag aagattcagg ccctggaccg cggcacagct cagtatggga tcaccaagtt 780
cagtgacctc acagaggagg aattccacac catctacctg aatcccctct tacagaagga 840
gtctggcagg aagatgagtc cagccaagtc cataaatgat cttgccccgc ctgaatggga 900
ctggaggaag aaaggggctg tcactgaagt gaagaaccag ggcatgtgtg gctcctgctg 960
ggccttttct gtcacaggca acgtggaggg ccagtggttc ctgaaccggg ggactctgct 1020
ctccctgtca gagcaggagc tcttggattg tgacaaggtg gacaaggcct gcttgggtgg 1080
attgccctcc aacgcctatg cagccataaa gaatttggga gggctggaga cagaggatga 1140
ctacggctac cagggccatg ttcagacctg caacttctca gcacagatgg caaaagtcta 1200
catcaatgat tcagtggagc tgagccggaa tgaaaataag atagcagcct ggctggccca 1260
gaaaggacct atctcagttg ccattaacgc cttcggcatg cagttctatc gccacgggat 1320
tgctcaccca ttccggcccc tctgcagccc ttggttcatc gaccatgctg tgttgctggt 1380
gggctatggc aaccgctcta acattcctta ctgggccatc aagaacagct ggggcagtga 1440
ctggggtgag gagggttact actacttgta ccgtggatct ggagcctgtg gtgtgaatac 1500
catggccagc tcagccgtgg tgaactgaga gttgctggct caggacctat gttgtcacag 1560
tggccccttc cttagcccga ctcatgccca ggcccttcct cacgagacag agctggttgg 1620
ctgagggccg ggcactttgg acctcacggt gagccctggg ccctgggccc cttcgtccct 1680
ctttcctcta gtgctcatct gaagttcccc agctgcacct gtgtccgatt gtggtagcta 1740
ggaggatcct gaggtgcagg aggctttcat ggaagccagc gccggggcaa gaacctggct 1800
acagtatgat gcaggatgaa aatatgctcg tcataaaact agatctgtcc tcagcaggct 1860
ctgtcttttt gctttggtgc tcctcggtct gatgctgtca gttttctggt ccctttccac 1920
atccaggaaa gttgtgaccg gccttctcta agggcaataa agaggtagcc tgctc      1975

<210> 70
<211> 462
<212> PRT
<213> Mus musculus

<220> 
<223> cathepsin F precursor

<400> 70
Met Ala Pro Leu Leu Gln Leu Leu Trp Leu Leu Thr Leu Leu Ser Thr
 1               5                  10                  15      
Val Ala Leu Ser Pro Val Pro Ala Lys Pro Trp Ala Asp Asp Glu Gln
            20                  25                  30          
Ala Trp Asn Leu Ser Ser Gln Glu Leu Leu Ala Pro Ala Arg Phe Ala
        35                  40                  45              
Leu Asp Met Tyr Asn Tyr Gly Arg Ala Ala Gly Thr Arg Ala Val Leu
    50                  55                  60                  
Gly Ala Val Arg Gly Arg Val Arg Arg Ala Gly Gln Gly Ser Leu Phe
65                  70                  75                  80  
Ser Leu Glu Ala Thr Leu Glu Glu Pro Pro Cys Asn Asp Pro Leu Val
                85                  90                  95      
Cys Pro Leu Pro Glu Thr Lys Lys Thr Val Leu Cys Ser Phe Glu Val
            100                 105                 110         
Leu Glu Glu Leu Lys Glu His Leu Leu Leu Arg Arg Asp Cys Ser Pro
        115                 120                 125             
Val Asn Ala Lys Val Thr Glu Phe Arg Asn Ala Thr Phe Ser Ser Phe
    130                 135                 140                 
Leu Pro Leu Leu Asp Lys Asp Pro Leu Pro Gln Asp Phe Ser Val Lys
145                 150                 155                 160 
Met Ala Pro Leu Phe Lys Asp Phe Met Thr Thr Tyr Asn Arg Thr Tyr
                165                 170                 175     
Glu Ser Arg Glu Glu Ala Gln Trp Arg Leu Thr Val Phe Ala Arg Asn
            180                 185                 190         
Met Ile Arg Ala Gln Lys Ile Gln Ala Leu Asp Arg Gly Thr Ala Gln
        195                 200                 205             
Tyr Gly Ile Thr Lys Phe Ser Asp Leu Thr Glu Glu Glu Phe His Thr
    210                 215                 220                 
Ile Tyr Leu Asn Pro Leu Leu Gln Lys Glu Ser Gly Arg Lys Met Ser
225                 230                 235                 240 
Pro Ala Lys Ser Ile Asn Asp Leu Ala Pro Pro Glu Trp Asp Trp Arg
                245                 250                 255     
Lys Lys Gly Ala Val Thr Glu Val Lys Asn Gln Gly Met Cys Gly Ser
            260                 265                 270         
Cys Trp Ala Phe Ser Val Thr Gly Asn Val Glu Gly Gln Trp Phe Leu
        275                 280                 285             
Asn Arg Gly Thr Leu Leu Ser Leu Ser Glu Gln Glu Leu Leu Asp Cys
    290                 295                 300                 
Asp Lys Val Asp Lys Ala Cys Leu Gly Gly Leu Pro Ser Asn Ala Tyr
305                 310                 315                 320 
Ala Ala Ile Lys Asn Leu Gly Gly Leu Glu Thr Glu Asp Asp Tyr Gly
                325                 330                 335     
Tyr Gln Gly His Val Gln Thr Cys Asn Phe Ser Ala Gln Met Ala Lys
            340                 345                 350         
Val Tyr Ile Asn Asp Ser Val Glu Leu Ser Arg Asn Glu Asn Lys Ile
        355                 360                 365             
Ala Ala Trp Leu Ala Gln Lys Gly Pro Ile Ser Val Ala Ile Asn Ala
    370                 375                 380                 
Phe Gly Met Gln Phe Tyr Arg His Gly Ile Ala His Pro Phe Arg Pro
385                 390                 395                 400 
Leu Cys Ser Pro Trp Phe Ile Asp His Ala Val Leu Leu Val Gly Tyr
                405                 410                 415     
Gly Asn Arg Ser Asn Ile Pro Tyr Trp Ala Ile Lys Asn Ser Trp Gly
            420                 425                 430         
Ser Asp Trp Gly Glu Glu Gly Tyr Tyr Tyr Leu Tyr Arg Gly Ser Gly
        435                 440                 445             
Ala Cys Gly Val Asn Thr Met Ala Ser Ser Ala Val Val Asn
    450                 455                 460         


<210> 71
<211> 214
<212> PRT
<213> Mus musculus

<220> 
<223> cathepsin F mature
      

<400> 71
Ala Pro Pro Glu Trp Asp Trp Arg Lys Lys Gly Ala Val Thr Glu Val
 1               5                  10                  15      
Lys Asn Gln Gly Met Cys Gly Ser Cys Trp Ala Phe Ser Val Thr Gly
            20                  25                  30          
Asn Val Glu Gly Gln Trp Phe Leu Asn Arg Gly Thr Leu Leu Ser Leu
        35                  40                  45              
Ser Glu Gln Glu Leu Leu Asp Cys Asp Lys Val Asp Lys Ala Cys Leu
    50                  55                  60                  
Gly Gly Leu Pro Ser Asn Ala Tyr Ala Ala Ile Lys Asn Leu Gly Gly
65                  70                  75                  80  
Leu Glu Thr Glu Asp Asp Tyr Gly Tyr Gln Gly His Val Gln Thr Cys
                85                  90                  95      
Asn Phe Ser Ala Gln Met Ala Lys Val Tyr Ile Asn Asp Ser Val Glu
            100                 105                 110         
Leu Ser Arg Asn Glu Asn Lys Ile Ala Ala Trp Leu Ala Gln Lys Gly
        115                 120                 125             
Pro Ile Ser Val Ala Ile Asn Ala Phe Gly Met Gln Phe Tyr Arg His
    130                 135                 140                 
Gly Ile Ala His Pro Phe Arg Pro Leu Cys Ser Pro Trp Phe Ile Asp
145                 150                 155                 160 
His Ala Val Leu Leu Val Gly Tyr Gly Asn Arg Ser Asn Ile Pro Tyr
                165                 170                 175     
Trp Ala Ile Lys Asn Ser Trp Gly Ser Asp Trp Gly Glu Glu Gly Tyr
            180                 185                 190         
Tyr Tyr Leu Tyr Arg Gly Ser Gly Ala Cys Gly Val Asn Thr Met Ala
        195                 200                 205             
Ser Ser Ala Val Val Asn
    210                 


<210> 72
<211> 3453
<212> DNA
<213> Mus musculus

<220> 
<223> cathepsin O precursor

<400> 72
gaaaccgaaa gagaaagcgg gccgggcaca gtggacctcg ggcaccggga tgaagccgca 60
gttggtgaac ctcttgctac tgtgttgctg ctgtctcggc cgccacgggg tcgccgggac 120
ctggtcttgg agccaccagc gggaggccgc cgccttgcgg gaaagccttc atagacaccg 180
atacttgaac tcttttcctc atgaaaactc cactgccttc tatggagtaa atcagttttc 240
ttatttgttt cctgaagagt ttaaagcttt gtatttaggc agcaaatatg cctgggctcc 300
cagataccca gcagaaggac agagacctat ccccaatgtg tctttgccat tgagatttga 360
ctggagggac aagcatgttg tgaatcctgt aaggaaccag gagatgtgtg gaggatgctg 420
ggccttcagc gtggtgagtg ccatagagtc agctcgtgca atccaaggga aatctctgga 480
ttacctgagc gtgcagcagg tcatcgactg ctcctttaat aattctggct gcctcggtgg 540
ctctcctctc tgtgccttgc gctggctaaa tgagacacag ttgaagttgg tggcagattc 600
acagtaccca ttcaaggcag taaatggcca gtgtcgccac tttcctcaat cacaagctgg 660
agtttcagtc aaggattttt ctgcatataa cttcaggggc caagaggatg aaatggccag 720
agcacttctg tccttcggcc ctttggttgt gatagttgat gcgatgagct ggcaggatta 780
tctggggggc ataatccaac atcactgctc cagtggggag gccaaccatg ccgttctcat 840
cacaggcttt gataggacag gaaatacacc atattggatg gtgcgaaact cctggggatc 900
ctcctgggga gtagaaggct atgcccacgt gaaaatggga ggtaatgttt gtggcattgc 960
agactctgta gctgctgtct ttgtgtgatc atgaattgtt ttggattcac catgagacaa 1020
ctacgaaaat gatgcacttc atagtgtgat ccaacatcat actcaactct aagcattatg 1080
caccttcaag ttccaacaat ttgtctacag agaggttcta agagcaaact ggcattttgt 1140
aaagcaacct aggacattct attttttgca aagacatgga cagccaaact tcataggaaa 1200
tccccaggac gttgactgat caacggactc tgtgggatag tgtgcacctc tgagagtttg 1260
gtgggatcag aagtcacata gtattctcct cctggaagca gttgggactt ttgcttgctt 1320
gttgtctttc tggctgtcta cattaaggaa gtattttggt cagggtgaat tgaagatatg 1380
atgagccttt gtttttccct tgtgacttat aatcaccagt cttagattac ctcatctaca 1440
agaactctca acctgatgca atgtgtgcct cataattaga atggccttct gttccatgtg 1500
aacagatttg gaatatcagt tgttttattt cagcaaatgg aacttactct agacagtaga 1560
acaaatgtgc accaagatga aacaacgatg cacaaagaga atcccatctt cagagagaca 1620
atccaactgg agttaaataa acacgtgaca acagtgtgat aaggagtaca ctatgccact 1680
tccagggagt catgatgtct ataaagcttc acttttaaac acccaaaatg tttagcttct 1740
tgccttcttc cctctgaggt agagaatgaa gtattgtcca catttattcc ctctcttgtc 1800
ctttatggta caagtcctat ggtttcctgg tggtttacct tccagtccaa agtaactcag 1860
taccgttggt tgtattccat ttctgttacc caatctctta cttaaaaaca aaatctctga 1920
cacaggctca cattgctcct tgtttatgtc cttcattaga ataccagcat caataacaaa 1980
gctccttact cttttgtctg taccagtgag aagcaatctt gaatgtgcag atcatggagg 2040
gtaaagaaac ggcagaagac atttcttaag gttttgaata aagtagccta attatcgaag 2100
gaatccagga aggaatgtag ttcagctata gtgtttctta atgactttca ttatgttatc 2160
agcaatgttt ctaataccca gtttcaaatg cagataaact tgaaattttc aaaatcactg 2220
ttactcttta agtattctgg attgataaca tttataataa tacaacctac atttgacttt 2280
gaattaaaag taacttattc ttaaatatgt agtctatgat ttattattat ttatgagcac 2340
taatagatat ttattagtat cgataagctt tatatttaca ttttcttgga tttgaaccct 2400
tatatccaat gtgcttttct ccatagatga ttttaattcc accatgtcca agattcctct 2460
catcatcttc ccatatctgt tgtcaatgct cagtggtcct cttctcctta ccttttcttt 2520
ctgtcagcag cattgctatt gtataagcag gccatagagt caaaaggaat tctagacaat 2580
caagttgtct cctccttaga acccattcct acatctgtct ccatcctctc tttcacgcat 2640
cctttctggg aggtacactt tttattatct cctatctaca ctcttcagtt gtttccagcc 2700
aacctaaaat aaaaagggag atatcttcat aaaagtttag gttttttttt tgtttgtttg 2760
tttgtttggt tggcttttgt cttttatttt tgtatagagt tatgatgagt tttgatgtga 2820
tgcacttcaa acactttttg tgatagtttt tgttatgtat caattatatg taacactccc 2880
tttcagtgac ttgttagctt tattcctttc gttttcttgt tagtgcctgg tgtaagtaac 2940
tccctatggt tctgacaacc tttattagta actaaactat gtgaccttta acacagtagg 3000
tcctgaacag taatctccag agcagaacag atggctttga aagatgctac tataatgtgt 3060
cctatatttc cccagattta tatttctaaa atgatgttat cattttactc acaagtttta 3120
cagcactgga aatcagtaag ataacatgca aattttttca aataagcatt atggagaggt 3180
ctctctctac ctttgtatcc cctgtaaata agtgatgacg catatacacc agctcatggg 3240
tgctcctgcc ccagaaaacc agagacagag cagccgaatg tgttccttac tacacagcat 3300
tcatactgaa gatcaccaac aggtcctgaa agtgatttga caaggtcccc attgcaactg 3360
ttaaatgggt caactttgca gtgcctttga aatatcccat cacttgggag gcagaggcag 3420
gtgaatttct gaggtcaagg ccagcccccc cac                              3453

<210> 73
<211> 312
<212> PRT
<213> Mus musculus

<220> 
<223> cathepsin O precursor

<400> 73
Met Lys Pro Gln Leu Val Asn Leu Leu Leu Leu Cys Cys Cys Cys Leu
 1               5                  10                  15      
Gly Arg His Gly Val Ala Gly Thr Trp Ser Trp Ser His Gln Arg Glu
            20                  25                  30          
Ala Ala Ala Leu Arg Glu Ser Leu His Arg His Arg Tyr Leu Asn Ser
        35                  40                  45              
Phe Pro His Glu Asn Ser Thr Ala Phe Tyr Gly Val Asn Gln Phe Ser
    50                  55                  60                  
Tyr Leu Phe Pro Glu Glu Phe Lys Ala Leu Tyr Leu Gly Ser Lys Tyr
65                  70                  75                  80  
Ala Trp Ala Pro Arg Tyr Pro Ala Glu Gly Gln Arg Pro Ile Pro Asn
                85                  90                  95      
Val Ser Leu Pro Leu Arg Phe Asp Trp Arg Asp Lys His Val Val Asn
            100                 105                 110         
Pro Val Arg Asn Gln Glu Met Cys Gly Gly Cys Trp Ala Phe Ser Val
        115                 120                 125             
Val Ser Ala Ile Glu Ser Ala Arg Ala Ile Gln Gly Lys Ser Leu Asp
    130                 135                 140                 
Tyr Leu Ser Val Gln Gln Val Ile Asp Cys Ser Phe Asn Asn Ser Gly
145                 150                 155                 160 
Cys Leu Gly Gly Ser Pro Leu Cys Ala Leu Arg Trp Leu Asn Glu Thr
                165                 170                 175     
Gln Leu Lys Leu Val Ala Asp Ser Gln Tyr Pro Phe Lys Ala Val Asn
            180                 185                 190         
Gly Gln Cys Arg His Phe Pro Gln Ser Gln Ala Gly Val Ser Val Lys
        195                 200                 205             
Asp Phe Ser Ala Tyr Asn Phe Arg Gly Gln Glu Asp Glu Met Ala Arg
    210                 215                 220                 
Ala Leu Leu Ser Phe Gly Pro Leu Val Val Ile Val Asp Ala Met Ser
225                 230                 235                 240 
Trp Gln Asp Tyr Leu Gly Gly Ile Ile Gln His His Cys Ser Ser Gly
                245                 250                 255     
Glu Ala Asn His Ala Val Leu Ile Thr Gly Phe Asp Arg Thr Gly Asn
            260                 265                 270         
Thr Pro Tyr Trp Met Val Arg Asn Ser Trp Gly Ser Ser Trp Gly Val
        275                 280                 285             
Glu Gly Tyr Ala His Val Lys Met Gly Gly Asn Val Cys Gly Ile Ala
    290                 295                 300                 
Asp Ser Val Ala Ala Val Phe Val
305                 310         


<210> 74
<211> 214
<212> PRT
<213> Mus musculus

<220> 
<223> cathepsin O mature

<400> 74
Leu Pro Leu Arg Phe Asp Trp Arg Asp Lys His Val Val Asn Pro Val
 1               5                  10                  15      
Arg Asn Gln Glu Met Cys Gly Gly Cys Trp Ala Phe Ser Val Val Ser
            20                  25                  30          
Ala Ile Glu Ser Ala Arg Ala Ile Gln Gly Lys Ser Leu Asp Tyr Leu
        35                  40                  45              
Ser Val Gln Gln Val Ile Asp Cys Ser Phe Asn Asn Ser Gly Cys Leu
    50                  55                  60                  
Gly Gly Ser Pro Leu Cys Ala Leu Arg Trp Leu Asn Glu Thr Gln Leu
65                  70                  75                  80  
Lys Leu Val Ala Asp Ser Gln Tyr Pro Phe Lys Ala Val Asn Gly Gln
                85                  90                  95      
Cys Arg His Phe Pro Gln Ser Gln Ala Gly Val Ser Val Lys Asp Phe
            100                 105                 110         
Ser Ala Tyr Asn Phe Arg Gly Gln Glu Asp Glu Met Ala Arg Ala Leu
        115                 120                 125             
Leu Ser Phe Gly Pro Leu Val Val Ile Val Asp Ala Met Ser Trp Gln
    130                 135                 140                 
Asp Tyr Leu Gly Gly Ile Ile Gln His His Cys Ser Ser Gly Glu Ala
145                 150                 155                 160 
Asn His Ala Val Leu Ile Thr Gly Phe Asp Arg Thr Gly Asn Thr Pro
                165                 170                 175     
Tyr Trp Met Val Arg Asn Ser Trp Gly Ser Ser Trp Gly Val Glu Gly
            180                 185                 190         
Tyr Ala His Val Lys Met Gly Gly Asn Val Cys Gly Ile Ala Asp Ser
        195                 200                 205             
Val Ala Ala Val Phe Val
    210                 


<210> 75
<211> 1335
<212> DNA
<213> Mus musculus

<220> 
<223> cathepsin R precursor

<400> 75
agcaactttt gaagagttga gtctgtggag tggattgagg cagaggcagt cacctcaggt 60
acttgagaca tggctgctgt tgtcttcata gccttcctgt atttgggagt ggcctcaggt 120
gttccagtac ttgattcaag tttggatgct gaatggcaag actggaagat aaagtataac 180
aaatcatata gcctgaagga agaaaaactg aagagagtgg tttgggaaga aaaattgaaa 240
atgatcaaac tacacaacag ggagaacagc ctgggtaaga atggcttcac catgaaaatg 300
aatgaatttg gtgaccagac tgatgaagaa ttcaggaaaa tgatgattga aatttcagtt 360
tggactcaca gagaggggaa aagtatcatg aaacgggaag ctggcagtat tctccccaaa 420
tttgtcgatt ggcgaaagaa aggatatgtg actcctgtac ggagacaggg agattgtgat 480
gcttgttggg catttgctgt gactggtgcc atagaagcac aggcaatctg gcaaacgggc 540
aaactcaccc ctctgagtgt gcagaacctg gtggactgtt ctaaacctca aggcaacaat 600
ggttgtcttg gtggtgatac atacaatgcc ttccagtatg ttttgcacaa tggtggtctg 660
gagtctgagg caacatatcc atatgaaggg aaagatggac catgcaggta taatccaaag 720
aattctaagg ctgaaatcac aggatttgtg tccctccccc aaagtgagga tatcctaatg 780
gctgctgtag caactattgg gcccatcact gctggaattg atgcttcaca tgagtctttc 840
aagaactata agggaggtat ttaccatgag ccaaattgta gcagtgatac tgtgactcat 900
ggagtcctcg tggttggtta cggatttaag ggaattgaga ccgatggtaa tcactactgg 960
ctgatcaaga atagctgggg taaacgatgg ggcattagag gctacatgaa gctcgccaaa 1020
gacaagaaca accactgtgg aattgcttca tatgctcact accctactat ttgagcaacc 1080
tggtggccac aaggaaggtt ttggcacaag acagcatttc taggggaggg ctatctgcta 1140
gtcagcgacc agcctttgct tggtatattc aagacttgtg tccctgaaga gcaaccttgt 1200
aatgtgattc tgggaccctt caactatttt gacatcatga acactattgc tctaactaac 1260
gtatgtttat tattccttca aaaaaatcag ctttaccgat tgtgcaaata aaatccttta 1320
aaaaataaaa tgcaa                                                  1335

<210> 76
<211> 334
<212> PRT
<213> Mus musculus

<220> 
<223> cathepsin R precursor

<400> 76
Met Ala Ala Val Val Phe Ile Ala Phe Leu Tyr Leu Gly Val Ala Ser
 1               5                  10                  15      
Gly Val Pro Val Leu Asp Ser Ser Leu Asp Ala Glu Trp Gln Asp Trp
            20                  25                  30          
Lys Ile Lys Tyr Asn Lys Ser Tyr Ser Leu Lys Glu Glu Lys Leu Lys
        35                  40                  45              
Arg Val Val Trp Glu Glu Lys Leu Lys Met Ile Lys Leu His Asn Arg
    50                  55                  60                  
Glu Asn Ser Leu Gly Lys Asn Gly Phe Thr Met Lys Met Asn Glu Phe
65                  70                  75                  80  
Gly Asp Gln Thr Asp Glu Glu Phe Arg Lys Met Met Ile Glu Ile Ser
                85                  90                  95      
Val Trp Thr His Arg Glu Gly Lys Ser Ile Met Lys Arg Glu Ala Gly
            100                 105                 110         
Ser Ile Leu Pro Lys Phe Val Asp Trp Arg Lys Lys Gly Tyr Val Thr
        115                 120                 125             
Pro Val Arg Arg Gln Gly Asp Cys Asp Ala Cys Trp Ala Phe Ala Val
    130                 135                 140                 
Thr Gly Ala Ile Glu Ala Gln Ala Ile Trp Gln Thr Gly Lys Leu Thr
145                 150                 155                 160 
Pro Leu Ser Val Gln Asn Leu Val Asp Cys Ser Lys Pro Gln Gly Asn
                165                 170                 175     
Asn Gly Cys Leu Gly Gly Asp Thr Tyr Asn Ala Phe Gln Tyr Val Leu
            180                 185                 190         
His Asn Gly Gly Leu Glu Ser Glu Ala Thr Tyr Pro Tyr Glu Gly Lys
        195                 200                 205             
Asp Gly Pro Cys Arg Tyr Asn Pro Lys Asn Ser Lys Ala Glu Ile Thr
    210                 215                 220                 
Gly Phe Val Ser Leu Pro Gln Ser Glu Asp Ile Leu Met Ala Ala Val
225                 230                 235                 240 
Ala Thr Ile Gly Pro Ile Thr Ala Gly Ile Asp Ala Ser His Glu Ser
                245                 250                 255     
Phe Lys Asn Tyr Lys Gly Gly Ile Tyr His Glu Pro Asn Cys Ser Ser
            260                 265                 270         
Asp Thr Val Thr His Gly Val Leu Val Val Gly Tyr Gly Phe Lys Gly
        275                 280                 285             
Ile Glu Thr Asp Gly Asn His Tyr Trp Leu Ile Lys Asn Ser Trp Gly
    290                 295                 300                 
Lys Arg Trp Gly Ile Arg Gly Tyr Met Lys Leu Ala Lys Asp Lys Asn
305                 310                 315                 320 
Asn His Cys Gly Ile Ala Ser Tyr Ala His Tyr Pro Thr Ile
                325                 330                 


<210> 77
<211> 220
<212> PRT
<213> Mus musculus

<220> 
<223> cathepsin R mature

<400> 77
Leu Pro Lys Phe Val Asp Trp Arg Lys Lys Gly Tyr Val Thr Pro Val
 1               5                  10                  15      
Arg Arg Gln Gly Asp Cys Asp Ala Cys Trp Ala Phe Ala Val Thr Gly
            20                  25                  30          
Ala Ile Glu Ala Gln Ala Ile Trp Gln Thr Gly Lys Leu Thr Pro Leu
        35                  40                  45              
Ser Val Gln Asn Leu Val Asp Cys Ser Lys Pro Gln Gly Asn Asn Gly
    50                  55                  60                  
Cys Leu Gly Gly Asp Thr Tyr Asn Ala Phe Gln Tyr Val Leu His Asn
65                  70                  75                  80  
Gly Gly Leu Glu Ser Glu Ala Thr Tyr Pro Tyr Glu Gly Lys Asp Gly
                85                  90                  95      
Pro Cys Arg Tyr Asn Pro Lys Asn Ser Lys Ala Glu Ile Thr Gly Phe
            100                 105                 110         
Val Ser Leu Pro Gln Ser Glu Asp Ile Leu Met Ala Ala Val Ala Thr
        115                 120                 125             
Ile Gly Pro Ile Thr Ala Gly Ile Asp Ala Ser His Glu Ser Phe Lys
    130                 135                 140                 
Asn Tyr Lys Gly Gly Ile Tyr His Glu Pro Asn Cys Ser Ser Asp Thr
145                 150                 155                 160 
Val Thr His Gly Val Leu Val Val Gly Tyr Gly Phe Lys Gly Ile Glu
                165                 170                 175     
Thr Asp Gly Asn His Tyr Trp Leu Ile Lys Asn Ser Trp Gly Lys Arg
            180                 185                 190         
Trp Gly Ile Arg Gly Tyr Met Lys Leu Ala Lys Asp Lys Asn Asn His
        195                 200                 205             
Cys Gly Ile Ala Ser Tyr Ala His Tyr Pro Thr Ile
    210                 215                 220 


<210> 78
<211> 1327
<212> DNA
<213> Homo sapiens

<220> 
<223> cathepsin W precursor

<400> 78
tgcgcggctt cctgcctcca tgccactcca gactgcaccg gcatggcact gactgcccac 60
ccctcctgcc tcctggccct gttggtggca ggcctagccc aaggcatcag aggccccctt 120
agggcccagg acctaggtcc ccagccgcta gagctgaaag aggccttcaa gttgttccag 180
atccagttca accggagtta cctgagccca gaagagcatg ctcaccgcct ggacatcttt 240
gcccacaacc tggcccaggc tcagaggctg caggaggagg acttgggcac agctgagttt 300
ggggtgactc cattcagtga cctcacagag gaggagtttg gccagctcta tggctatcgg 360
agggcagctg gaggggtccc cagcatgggc agagaaataa ggtctgaaga gccagaggag 420
tcagtacctt tcagctgtga ctggcggaag gtggccggcg ccatctcacc catcaaggac 480
cagaaaaact gcaactgctg ctgggccatg gcagcggcag gcaacataga gaccctgtgg 540
cgcatcagtt tctgggattt tgtggacgtc tccgtgcagg aactgctgga ctgtggccgc 600
tgtggggatg gctgccacgg tggcttcgtc tgggacgcgt tcataactgt cctcaacaac 660
agcggcctgg ccagtgaaaa ggactacccg ttccagggca aagtcagagc ccacaggtgc 720
caccccaaga agtaccagaa ggtggcctgg atccaggact tcatcatgct gcagaacaac 780
gagcacagaa ttgcgcagta cctggccact tatggcccca tcaccgtgac catcaacatg 840
aagccccttc agctataccg gaaaggtgtg atcaaggcca cacccaccac ctgtgacccc 900
cagcttgtgg accactctgt cctgctggtg ggttttggca gcgtcaagtc agaggagggg 960
atatgggcag agacagtctc atcgcagtct cagcctcagc ctccacaccc caccccatac 1020
tggatcctga agaactcctg gggggcccaa tggggagaga agggctattt ccggctgcac 1080
cgagggagca atacctgtgg catcaccaag ttcccgctca ctgcccgtgt gcagaaaccg 1140
gatatgaagc cccgagtctc ctgccctccc tgaacccacc tggccccctc agctctgtcc 1200
tgttaggcca actgcctcct tgccagcccc acccccaggt ttttgcccat cctcccaatc 1260
tcaatacagc ctgaataaac caagacaaga cctctgaaaa aaaaaaaaaa aaaaaaaaaa 1320
aaaaaaa                                                           1327

<210> 79
<211> 376
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin W precursor

<400> 79
Met Ala Leu Thr Ala His Pro Ser Cys Leu Leu Ala Leu Leu Val Ala
 1               5                  10                  15      
Gly Leu Ala Gln Gly Ile Arg Gly Pro Leu Arg Ala Gln Asp Leu Gly
            20                  25                  30          

Pro Gln Pro Leu Glu Leu Lys Glu Ala Phe Lys Leu Phe Gln Ile Gln
        35                  40                  45              
Phe Asn Arg Ser Tyr Leu Ser Pro Glu Glu His Ala His Arg Leu Asp
    50                  55                  60                  
Ile Phe Ala His Asn Leu Ala Gln Ala Gln Arg Leu Gln Glu Glu Asp
65                  70                  75                  80  
Leu Gly Thr Ala Glu Phe Gly Val Thr Pro Phe Ser Asp Leu Thr Glu
                85                  90                  95      
Glu Glu Phe Gly Gln Leu Tyr Gly Tyr Arg Arg Ala Ala Gly Gly Val
            100                 105                 110         
Pro Ser Met Gly Arg Glu Ile Arg Ser Glu Glu Pro Glu Glu Ser Val
        115                 120                 125             
Pro Phe Ser Cys Asp Trp Arg Lys Val Ala Gly Ala Ile Ser Pro Ile
    130                 135                 140                 
Lys Asp Gln Lys Asn Cys Asn Cys Cys Trp Ala Met Ala Ala Ala Gly
145                 150                 155                 160 
Asn Ile Glu Thr Leu Trp Arg Ile Ser Phe Trp Asp Phe Val Asp Val
                165                 170                 175     
Ser Val Gln Glu Leu Leu Asp Cys Gly Arg Cys Gly Asp Gly Cys His
            180                 185                 190         
Gly Gly Phe Val Trp Asp Ala Phe Ile Thr Val Leu Asn Asn Ser Gly
        195                 200                 205             
Leu Ala Ser Glu Lys Asp Tyr Pro Phe Gln Gly Lys Val Arg Ala His
    210                 215                 220                 
Arg Cys His Pro Lys Lys Tyr Gln Lys Val Ala Trp Ile Gln Asp Phe
225                 230                 235                 240 
Ile Met Leu Gln Asn Asn Glu His Arg Ile Ala Gln Tyr Leu Ala Thr
                245                 250                 255     
Tyr Gly Pro Ile Thr Val Thr Ile Asn Met Lys Pro Leu Gln Leu Tyr
            260                 265                 270         
Arg Lys Gly Val Ile Lys Ala Thr Pro Thr Thr Cys Asp Pro Gln Leu
        275                 280                 285             
Val Asp His Ser Val Leu Leu Val Gly Phe Gly Ser Val Lys Ser Glu
    290                 295                 300                 
Glu Gly Ile Trp Ala Glu Thr Val Ser Ser Gln Ser Gln Pro Gln Pro
305                 310                 315                 320 
Pro His Pro Thr Pro Tyr Trp Ile Leu Lys Asn Ser Trp Gly Ala Gln
                325                 330                 335     
Trp Gly Glu Lys Gly Tyr Phe Arg Leu His Arg Gly Ser Asn Thr Cys
            340                 345                 350         
Gly Ile Thr Lys Phe Pro Leu Thr Ala Arg Val Gln Lys Pro Asp Met
        355                 360                 365             
Lys Pro Arg Val Ser Cys Pro Pro
    370                 375     


<210> 80
<211> 249
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin W mature

<400> 80
Val Pro Phe Ser Cys Asp Trp Arg Lys Val Ala Gly Ala Ile Ser Pro
 1               5                  10                  15      
Ile Lys Asp Gln Lys Asn Cys Asn Cys Cys Trp Ala Met Ala Ala Ala
            20                  25                  30          
Gly Asn Ile Glu Thr Leu Trp Arg Ile Ser Phe Trp Asp Phe Val Asp
        35                  40                  45              
Val Ser Val His Glu Leu Leu Asp Cys Gly Arg Cys Gly Asp Gly Cys
    50                  55                  60                  
His Gly Gly Phe Val Trp Asp Ala Phe Ile Thr Val Leu Asn Asn Ser
65                  70                  75                  80  
Gly Leu Ala Ser Glu Lys Asp Tyr Pro Phe Gln Gly Lys Val Arg Ala
                85                  90                  95      
His Arg Cys His Pro Lys Lys Tyr Gln Lys Val Ala Trp Ile Gln Asp
            100                 105                 110         
Phe Ile Met Leu Gln Asn Asn Glu His Arg Ile Ala Gln Tyr Leu Ala
        115                 120                 125             
Thr Tyr Gly Pro Ile Thr Val Thr Ile Asn Met Lys Pro Leu Gln Leu
    130                 135                 140                 
Tyr Arg Lys Gly Val Ile Lys Ala Thr Pro Thr Thr Cys Asp Pro Gln
145                 150                 155                 160 
Leu Val Asp His Ser Val Leu Leu Val Gly Phe Gly Ser Val Lys Ser
                165                 170                 175     
Glu Glu Gly Ile Trp Ala Glu Thr Val Ser Ser Gln Ser Gln Pro Gln
            180                 185                 190         
Pro Pro His Pro Thr Pro Tyr Trp Ile Leu Lys Asn Ser Trp Gly Ala
        195                 200                 205             
Gln Trp Gly Glu Lys Gly Tyr Phe Arg Leu His Arg Gly Ser Asn Thr
    210                 215                 220                 
Cys Gly Ile Thr Lys Phe Pro Leu Thr Ala Arg Val Gln Lys Pro Asp
225                 230                 235                 240 
Met Lys Pro Arg Val Ser Cys Pro Pro
                245                 


<210> 81
<211> 3007
<212> DNA
<213> Homo sapiens

<220> 
<223> calpain 1 large subunit precursor

<400> 81
aaggagagag ggagggcgga gggcggaggg gcggcgggag gagggcgggg aggagcgctc 60
ttcctggttg ggccctgccc tgagctgcca ccgggaagcc agcctcaggg actgcagcga 120
cccccaaaca cccctccccc aggatgtcgg aggagatcat cacgccggtg tactgcactg 180
gggtgtcagc ccaagtgcag aagcagcggg ccagggagct gggcctgggc cgccatgaga 240
atgccatcaa gtacctgggc caggattatg agcagctgcg ggtgcgatgc ctgcagagtg 300
ggaccctctt ccgtgatgag gccttccccc cggtacccca gagcctgggt tacaaggacc 360
tgggtcccaa ttcctccaag acctatggca tcaagtggaa gcgtcccacg gaactgctgt 420
caaaccccca gttcattgtg gatggagcta cccgcacaga catctgccag ggagcactgg 480
gggactgctg gctcttggcg gccattgcct ccctcactct caacgacacc ctcctgcacc 540
gagtggttcc gcacggccag agcttccaga atggctatgc cggcatcttc catttccagc 600
tgtggcaatt tggggagtgg gtggacgtgg tcgtggatga cctgctgccc atcaaggacg 660
ggaagctagt gttcgtgcac tctgccgaag gcaacgagtt ctggagcgcc ctgcttgaga 720
aggcctatgc caaggtaaat ggcagctacg aggccctgtc agggggcagc acctcagagg 780
gctttgagga cttcacaggc ggggttaccg agtggtacga gttgcgcaag gctcccagtg 840
acctctacca gatcatcctc aaggcgctgg agcggggctc cctgctgggc tgctccatag 900
acatctccag cgttctagac atggaggcca tcactttcaa gaagttggtg aagggccatg 960
cctactctgt gaccggggcc aagcaggtga actaccgagg ccaggtggtg agcctgatcc 1020
ggatgcggaa cccctggggc gaggtggagt ggacgggagc ctggagcgac agctcctcag 1080
agtggaacaa cgtggaccca tatgaacggg accagctccg ggtcaagatg gaggacgggg 1140
agttctggat gtcattccga gacttcatgc gggagttcac ccgcctggag atctgcaacc 1200
tcacacccga cgccctcaag agccggacca tccgcaaatg gaacaccaca ctctacgaag 1260
gcacctggcg gcgggggagc accgcggggg gctgccgaaa ctacccagcc accttctggg 1320
tgaaccctca gttcaagatc cggctggatg agacggatga cccggacgac tacggggacc 1380
gcgagtcagg ctgcagcttc gtgctcgccc ttatgcagaa gcaccgtcgc cgcgagcgcc 1440
gcttcggccg cgacatggag actattggct tcgcggtcta cgaggtccct ccggagctgg 1500
tgggccagcc ggccgtacac ttgaagcgtg acttcttcct ggccaatgcg tctcgggcgc 1560
gctcagagca gttcatcaac ctgcgagagg tcagcacccg cttccgcctg ccacccgggg 1620
agtatgtggt ggtgccctcc accttcgagc ccaacaagga gggcgacttc gtgctgcgct 1680
tcttctcaga gaagagtgct gggactgtgg agctggatga ccagatccag gccaatctcc 1740
ccgatgagca agtgctctca gaagaggaga ttgacgagaa cttcaaggcc ctcttcaggc 1800
agctggcagg ggaggacatg gagatcagcg tgaaggagtt gcggacaatc ctcaatagga 1860
tcatcagcaa acacaaagac ctgcggacca agggcttcag cctagagtcg tgccgcagca 1920
tggtgaacct catggatcgt gatggcaatg ggaagctggg cctggtggag ttcaacatcc 1980
tgtggaaccg catccggaat tacctgtcca tcttccggaa gtttgacctg gacaagtcgg 2040
gcagcatgag tgcctacgag atgcggatgg ccattgagtc ggcaggcttc aagctcaaca 2100
agaagctgta cgagctcatc atcacccgct actcggagcc cgacctggcg gtcgactttg 2160
acaatttcgt ttgctgcctg gtgcggctag agaccatgtt ccgatttttc aaaactctgg 2220
acacagatct ggatggagtt gtgacctttg acttgtttaa gtggttgcag ctgaccatgt 2280
ttgcatgagg cagggactcg gtcccccttg ccgtgctccc ctccctcctc gtctgccaag 2340
cctcgcctcc taccacacca caccaggcca ccccagctgc aagtgccttc cttggagcag 2400
agaggcagcc tcgtcctcct gtcccctctc ctcccagcca ccatcgttca tctgctccgg 2460
gcagaactgt gtggcccctg cctgtgccag ccatgggctc gggatggact ccctgggccc 2520
cacccattgc caagccagga aggcagcttt cgcttgttcc tgcctcggga cagccccggg 2580
tttccccagc atcctgatgt gtcccctctc cccacttcag aggccaccca ctcagcacca 2640
ccggcctggc cttgcctgca gactataaac tataaccact agctcgacac agtctgcagt 2700
ccaggcgtgt ggagccgcct cccggctcgg ggaggccccg gggctgggaa cgcctgtgcc 2760
ttcctgcgcc gaagccaacg ccccctctgt ccttccctgg ccctgctgcc gaccaggagc 2820
tgcccagcct gtgggcggtc ggccttccct ccttcgctcc ttttttatat tagtgatttt 2880
aaaggggact cttcagggac ttgtgtactg gttatggggg tgccagaggc actaggcttg 2940
gggtggggag gtcccgtgtt ccatatagag gaaccccaaa taataaaagg ccccacatct 3000
gtctgtg                                                           3007

<210> 82
<211> 714
<212> PRT
<213> Homo sapiens

<220> 
<223> calpain 1 large subunit

<400> 82
Met Ser Glu Glu Ile Ile Thr Pro Val Tyr Cys Thr Gly Val Ser Ala
 1               5                  10                  15      
Gln Val Gln Lys Gln Arg Ala Arg Glu Leu Gly Leu Gly Arg His Glu
            20                  25                  30          
Asn Ala Ile Lys Tyr Leu Gly Gln Asp Tyr Glu Gln Leu Arg Val Arg
        35                  40                  45              
Cys Leu Gln Ser Gly Thr Leu Phe Arg Asp Glu Ala Phe Pro Pro Val
    50                  55                  60                  
Pro Gln Ser Leu Gly Tyr Lys Asp Leu Gly Pro Asn Ser Ser Lys Thr
65                  70                  75                  80  
Tyr Gly Ile Lys Trp Lys Arg Pro Thr Glu Leu Leu Ser Asn Pro Gln
                85                  90                  95      
Phe Ile Val Asp Gly Ala Thr Arg Thr Asp Ile Cys Gln Gly Ala Leu
            100                 105                 110         
Gly Asp Cys Trp Leu Leu Ala Ala Ile Ala Ser Leu Thr Leu Asn Asp
        115                 120                 125             
Thr Leu Leu His Arg Val Val Pro His Gly Gln Ser Phe Gln Asn Gly
    130                 135                 140                 
Tyr Ala Gly Ile Phe His Phe Gln Leu Trp Gln Phe Gly Glu Trp Val
145                 150                 155                 160 
Asp Val Val Val Asp Asp Leu Leu Pro Ile Lys Asp Gly Lys Leu Val
                165                 170                 175     
Phe Val His Ser Ala Glu Gly Asn Glu Phe Trp Ser Ala Leu Leu Glu
            180                 185                 190         
Lys Ala Tyr Ala Lys Val Asn Gly Ser Tyr Glu Ala Leu Ser Gly Gly
        195                 200                 205             
Ser Thr Ser Glu Gly Phe Glu Asp Phe Thr Gly Gly Val Thr Glu Trp
    210                 215                 220                 
Tyr Glu Leu Arg Lys Ala Pro Ser Asp Leu Tyr Gln Ile Ile Leu Lys
225                 230                 235                 240 
Ala Leu Glu Arg Gly Ser Leu Leu Gly Cys Ser Ile Asp Ile Ser Ser
                245                 250                 255     
Val Leu Asp Met Glu Ala Ile Thr Phe Lys Lys Leu Val Lys Gly His
            260                 265                 270         
Ala Tyr Ser Val Thr Gly Ala Lys Gln Val Asn Tyr Arg Gly Gln Val
        275                 280                 285             
Val Ser Leu Ile Arg Met Arg Asn Pro Trp Gly Glu Val Glu Trp Thr
    290                 295                 300                 
Gly Ala Trp Ser Asp Ser Ser Ser Glu Trp Asn Asn Val Asp Pro Tyr
305                 310                 315                 320 
Glu Arg Asp Gln Leu Arg Val Lys Met Glu Asp Gly Glu Phe Trp Met
                325                 330                 335     
Ser Phe Arg Asp Phe Met Arg Glu Phe Thr Arg Leu Glu Ile Cys Asn
            340                 345                 350         
Leu Thr Pro Asp Ala Leu Lys Ser Arg Thr Ile Arg Lys Trp Asn Thr
        355                 360                 365             
Thr Leu Tyr Glu Gly Thr Trp Arg Arg Gly Ser Thr Ala Gly Gly Cys
    370                 375                 380                 
Arg Asn Tyr Pro Ala Thr Phe Trp Val Asn Pro Gln Phe Lys Ile Arg
385                 390                 395                 400 
Leu Asp Glu Thr Asp Asp Pro Asp Asp Tyr Gly Asp Arg Glu Ser Gly
                405                 410                 415     
Cys Ser Phe Val Leu Ala Leu Met Gln Lys His Arg Arg Arg Glu Arg
            420                 425                 430         
Arg Phe Gly Arg Asp Met Glu Thr Ile Gly Phe Ala Val Tyr Glu Val
        435                 440                 445             
Pro Pro Glu Leu Val Gly Gln Pro Ala Val His Leu Lys Arg Asp Phe
    450                 455                 460                 
Phe Leu Ala Asn Ala Ser Arg Ala Arg Ser Glu Gln Phe Ile Asn Leu
465                 470                 475                 480 
Arg Glu Val Ser Thr Arg Phe Arg Leu Pro Pro Gly Glu Tyr Val Val
                485                 490                 495     
Val Pro Ser Thr Phe Glu Pro Asn Lys Glu Gly Asp Phe Val Leu Arg
            500                 505                 510         
Phe Phe Ser Glu Lys Ser Ala Gly Thr Val Glu Leu Asp Asp Gln Ile
        515                 520                 525             
Gln Ala Asn Leu Pro Asp Glu Gln Val Leu Ser Glu Glu Glu Ile Asp
    530                 535                 540                 
Glu Asn Phe Lys Ala Leu Phe Arg Gln Leu Ala Gly Glu Asp Met Glu
545                 550                 555                 560 
Ile Ser Val Lys Glu Leu Arg Thr Ile Leu Asn Arg Ile Ile Ser Lys
                565                 570                 575     
His Lys Asp Leu Arg Thr Lys Gly Phe Ser Leu Glu Ser Cys Arg Ser
            580                 585                 590         
Met Val Asn Leu Met Asp Arg Asp Gly Asn Gly Lys Leu Gly Leu Val
        595                 600                 605             
Glu Phe Asn Ile Leu Trp Asn Arg Ile Arg Asn Tyr Leu Ser Ile Phe
    610                 615                 620                 
Arg Lys Phe Asp Leu Asp Lys Ser Gly Ser Met Ser Ala Tyr Glu Met
625                 630                 635                 640 
Arg Met Ala Ile Glu Ser Ala Gly Phe Lys Leu Asn Lys Lys Leu Tyr
                645                 650                 655     
Glu Leu Ile Ile Thr Arg Tyr Ser Glu Pro Asp Leu Ala Val Asp Phe
            660                 665                 670         
Asp Asn Phe Val Cys Cys Leu Val Arg Leu Glu Thr Met Phe Arg Phe
        675                 680                 685             
Phe Lys Thr Leu Asp Thr Asp Leu Asp Gly Val Val Thr Phe Asp Leu
    690                 695                 700                 
Phe Lys Trp Leu Gln Leu Thr Met Phe Ala
705                 710                 


<210> 83
<211> 3492
<212> DNA
<213> Homo sapiens

<220> 
<223> calpain 2 large subunit precursor

<400> 83
caggccgcag gatggcctgg tcccgggccg ggagcccagc aggccgggag cggctgaggc 60
cacaccccgc gggccgggcc gcttccctcc ggtgaatcat cgctcgcagc ggcggcgccc 120
gcagtggccg cagcagcgcg ccgggccctg gccgcgcccc agccgagcgc agcgcggagt 180
cgccccgacc tttctctgcg cagtacggcc gccgggaccg cagcatggcg ggcatcgcgg 240
ccaagctggc gaaggaccgg gaggcggccg aggggctggg ctcccacgag agggccatca 300
agtacctcaa ccaggactac gaggcgctgc ggaacgagtg cctggaggcc gggacgctct 360
tccaggaccc gtccttcccg gccatcccct cggccctggg cttcaaggag ttggggccct 420
actccagcaa aacccggggc atcgagtgga agcgccccac ggagatctgc gctgaccccc 480
agtttatcat tggaggagcc acccgcacag acatctgcca aggagccctg ggtgactgct 540
ggctgctggc agccattgcc tccctcacct tgaatgaaga aatcctggct cgagtcgtcc 600
ccctaaacca gagcttccag gaaaactatg cagggatctt tcacttccag ttctggcaat 660
acggcgagtg ggtggaggtg gtggtggatg acaggctgcc caccaaggac ggggagctgc 720
tctttgtgca ttcagccgaa gggagcgagt tctggagcgc cctgctggag aaggcatacg 780
ccaagatcaa cggatgctat gaagcgctat cagggggtgc caccactgag ggcttcgaag 840
acttcaccgg aggcattgct gagtggtatg agttgaagaa gccccctccc aacctgttca 900
agatcatcca gaaagctctg caaaaaggct ctctccttgg ctgctccatc gacatcacca 960
gcgccgcgga ctcggaggcc atcacgtttc agaagctggt gaaggggcac gcgtactcgg 1020
tcaccggagc cgaggaggtt gaaagtaacg gaagcctaca gaaactgatc cgcatccgaa 1080
atccctgggg agaagtggag tggacagggc ggtggaatga caactgccca agctggaaca 1140
ctatagaccc agaggagagg gaaaggctga ccagacggca tgaagatgga gaattctgga 1200
tgtctttcag tgacttcctg aggcactatt cccgcctgga gatctgtaac ctgaccccag 1260
acactctcac cagcgatacc tacaagaagt ggaaactcac caaaatggat gggaactgga 1320
ggcggggctc caccgcggga ggttgcagga actacccgaa cacattctgg atgaaccctc 1380
agtacctgat caagctggag gaggaggatg aggacgagga ggatggggag agcggctgca 1440
ccttcctggt ggggctcatt cagaagcacc gacggcggca gaggaagatg ggcgaggaca 1500
tgcacaccat cggctttggc atctatgagg ttccagagga gttaagtggg cagaccaaca 1560
tccacctcag caaaaacttc ttcctgacga atcgcgccag ggagcgctca gacaccttca 1620
tcaacctccg ggaggtgctc aaccgcttca agctgccgcc aggagagtac attctcgtgc 1680
cttccacctt cgaacccaac aaggatgggg atttctgcat ccgggtcttt tctgaaaaga 1740
aagctgacta ccaagctgtc gatgatgaaa tcgaggccaa tcttgaagag ttcgacatca 1800
gcgaggatga cattgatgat ggattcagga gactgtttgc ccagttggca ggagaggatg 1860
cggagatctc tgcctttgag ctgcagacca tcctgagaag ggttctagca aagcgccaag 1920
atatcaagtc agatggcttc agcatcgaga catgcaaaat tatggttgac atgctagatt 1980
cggacgggag tggcaagctg gggctgaagg agttctacat tctctggacg aagattcaaa 2040
aataccaaaa aatttaccga gaaatcgacg ttgacaggtc tggtaccatg aattcctatg 2100
aaatgcggaa ggcattagaa gaagcaggtt tcaagatgcc ctgtcaactc caccaagtca 2160
tcgttgctcg gtttgcagat gaccagctca tcatcgattt tgataatttt gttcggtgtt 2220
tggttcggct ggaaacgcta ttcaagatat ttaagcagct ggatcccgag aatactggaa 2280
caatagagct cgaccttatc tcttggctct gtttctcagt actttgaagt tataactaat 2340
ctgcctgaag acttctcatg atggaaaatc agccaaggac taagcttcca tagaaataca 2400
ctttgtatct ggacctcaaa attatgggaa catttactta aacggatgat catagctgaa 2460
aataatgata ctgtcaattt gagatagcag aagtttcaca catcaaagta aaagatttgc 2520
atatcattat actaaatgca aatgagtcgc ttaacccttg acaaggtcaa agaaagcttt 2580
aaatctgtaa atagtataca ctttttactt ttacacactt tcctgttcat agcaatatta 2640
aatcaggaaa aaaaaatgca gggaggtatt taacagctga gcaaaaacat tgagtcgctc 2700
tcaaaggaca cgaggccctt ggcagggaat atttaaagca acttcaagtt taaaatgcag 2760
ctgttgattc taccaaacaa cagtccaaga ttaccatttc ccatgagcca actgggaaac 2820
atggtatatc atgaagtaat cttgtcaagg catctggaga gtccaggaga gaagactcac 2880
ctctgtcgct tgggttaaac aagagacagg ttttgtagaa tattgattgg taatagtaaa 2940
tcgttctcct tacaatcaag ttcttgaccc tattcggcct tatacatctg gtcttacaaa 3000
gaccaaaggg atcctgcgct tgatcaactg aaccagtatg ccaaaaccag gcatccaatt 3060
tgtaaaccaa ttatgataaa ggacaaaata agctgtttgc cacctcaaaa ctttatgaac 3120
ttcaccacca ctagtgtctg tccatggagt tagaggggac atcacttaga agttcttata 3180
gaaaggacac aagtttgttt cctggcttta ccttgggaaa atgctagcaa cattatagaa 3240
attttgcctt gttgccttat cttcttccaa atgtactgtt aaataaaaat aaagggttac 3300
cccatgcaat cacaccatgc catgttttcc ttcctggagg gcagccccac aggacggttt 3360
atgagcacac aattatagct tgtttctact ttaacaaggt atgctgcctc tgtaaattca 3420
tgtattcaaa ggaaaagaca ccttgcctat aattaaaatg tggaactata aaatttttta 3480
aaatccaaaa aa                                                     3492

<210> 84
<211> 700
<212> PRT
<213> Homo sapiens

<220> 
<223> calpain 2 large subunit precursor

<400> 84
Met Ala Gly Ile Ala Ala Lys Leu Ala Lys Asp Arg Glu Ala Ala Glu
 1               5                  10                  15      
Gly Leu Gly Ser His Glu Arg Ala Ile Lys Tyr Leu Asn Gln Asp Tyr
            20                  25                  30          
Glu Ala Leu Arg Asn Glu Cys Leu Glu Ala Gly Thr Leu Phe Gln Asp
        35                  40                  45              
Pro Ser Phe Pro Ala Ile Pro Ser Ala Leu Gly Phe Lys Glu Leu Gly
    50                  55                  60                  
Pro Tyr Ser Ser Lys Thr Arg Gly Ile Glu Trp Lys Arg Pro Thr Glu
65                  70                  75                  80  
Ile Cys Ala Asp Pro Gln Phe Ile Ile Gly Gly Ala Thr Arg Thr Asp
                85                  90                  95      
Ile Cys Gln Gly Ala Leu Gly Asp Cys Trp Leu Leu Ala Ala Ile Ala
            100                 105                 110         
Ser Leu Thr Leu Asn Glu Glu Ile Leu Ala Arg Val Val Pro Leu Asn
        115                 120                 125             
Gln Ser Phe Gln Glu Asn Tyr Ala Gly Ile Phe His Phe Gln Phe Trp
    130                 135                 140                 
Gln Tyr Gly Glu Trp Val Glu Val Val Val Asp Asp Arg Leu Pro Thr
145                 150                 155                 160 
Lys Asp Gly Glu Leu Leu Phe Val His Ser Ala Glu Gly Ser Glu Phe
                165                 170                 175     
Trp Ser Ala Leu Leu Glu Lys Ala Tyr Ala Lys Ile Asn Gly Cys Tyr
            180                 185                 190         
Glu Ala Leu Ser Gly Gly Ala Thr Thr Glu Gly Phe Glu Asp Phe Thr
        195                 200                 205             
Gly Gly Ile Ala Glu Trp Tyr Glu Leu Lys Lys Pro Pro Pro Asn Leu
    210                 215                 220                 
Phe Lys Ile Ile Gln Lys Ala Leu Gln Lys Gly Ser Leu Leu Gly Cys
225                 230                 235                 240 
Ser Ile Asp Ile Thr Ser Ala Ala Asp Ser Glu Ala Ile Thr Phe Gln
                245                 250                 255     
Lys Leu Val Lys Gly His Ala Tyr Ser Val Thr Gly Ala Glu Glu Val
            260                 265                 270         
Glu Ser Asn Gly Ser Leu Gln Lys Leu Ile Arg Ile Arg Asn Pro Trp
        275                 280                 285             
Gly Glu Val Glu Trp Thr Gly Arg Trp Asn Asp Asn Cys Pro Ser Trp
    290                 295                 300                 
Asn Thr Ile Asp Pro Glu Glu Arg Glu Arg Leu Thr Arg Arg His Glu
305                 310                 315                 320 
Asp Gly Glu Phe Trp Met Ser Phe Ser Asp Phe Leu Arg His Tyr Ser
                325                 330                 335     
Arg Leu Glu Ile Cys Asn Leu Thr Pro Asp Thr Leu Thr Ser Asp Thr
            340                 345                 350         
Tyr Lys Lys Trp Lys Leu Thr Lys Met Asp Gly Asn Trp Arg Arg Gly
        355                 360                 365             
Ser Thr Ala Gly Gly Cys Arg Asn Tyr Pro Asn Thr Phe Trp Met Asn
    370                 375                 380                 
Pro Gln Tyr Leu Ile Lys Leu Glu Glu Glu Asp Glu Asp Glu Glu Asp
385                 390                 395                 400 
Gly Glu Ser Gly Cys Thr Phe Leu Val Gly Leu Ile Gln Lys His Arg
                405                 410                 415     
Arg Arg Gln Arg Lys Met Gly Glu Asp Met His Thr Ile Gly Phe Gly
            420                 425                 430         
Ile Tyr Glu Val Pro Glu Glu Leu Ser Gly Gln Thr Asn Ile His Leu
        435                 440                 445             
Ser Lys Asn Phe Phe Leu Thr Asn Arg Ala Arg Glu Arg Ser Asp Thr
    450                 455                 460                 
Phe Ile Asn Leu Arg Glu Val Leu Asn Arg Phe Lys Leu Pro Pro Gly
465                 470                 475                 480 
Glu Tyr Ile Leu Val Pro Ser Thr Phe Glu Pro Asn Lys Asp Gly Asp
                485                 490                 495     
Phe Cys Ile Arg Val Phe Ser Glu Lys Lys Ala Asp Tyr Gln Ala Val
            500                 505                 510         
Asp Asp Glu Ile Glu Ala Asn Leu Glu Glu Phe Asp Ile Ser Glu Asp
        515                 520                 525             
Asp Ile Asp Asp Gly Phe Arg Arg Leu Phe Ala Gln Leu Ala Gly Glu
    530                 535                 540                 
Asp Ala Glu Ile Ser Ala Phe Glu Leu Gln Thr Ile Leu Arg Arg Val
545                 550                 555                 560 
Leu Ala Lys Arg Gln Asp Ile Lys Ser Asp Gly Phe Ser Ile Glu Thr
                565                 570                 575     
Cys Lys Ile Met Val Asp Met Leu Asp Ser Asp Gly Ser Gly Lys Leu
            580                 585                 590         
Gly Leu Lys Glu Phe Tyr Ile Leu Trp Thr Lys Ile Gln Lys Tyr Gln
        595                 600                 605             
Lys Ile Tyr Arg Glu Ile Asp Val Asp Arg Ser Gly Thr Met Asn Ser
    610                 615                 620                 
Tyr Glu Met Arg Lys Ala Leu Glu Glu Ala Gly Phe Lys Met Pro Cys
625                 630                 635                 640 
Gln Leu His Gln Val Ile Val Ala Arg Phe Ala Asp Asp Gln Leu Ile
                645                 650                 655     
Ile Asp Phe Asp Asn Phe Val Arg Cys Leu Val Arg Leu Glu Thr Leu
            660                 665                 670         
Phe Lys Ile Phe Lys Gln Leu Asp Pro Glu Asn Thr Gly Thr Ile Glu
        675                 680                 685             
Leu Asp Leu Ile Ser Trp Leu Cys Phe Ser Val Leu
    690                 695                 700 


<210> 85
<211> 699
<212> PRT
<213> Homo sapiens

<220> 
<223> calpain 2 large subunit

<400> 85
Ala Gly Ile Ala Ala Lys Leu Ala Lys Asp Arg Glu Ala Ala Glu Gly
 1               5                  10                  15      
Leu Gly Ser His Glu Arg Ala Ile Lys Tyr Leu Asn Gln Asp Tyr Glu
            20                  25                  30          
Ala Leu Arg Asn Glu Cys Leu Glu Ala Gly Thr Leu Phe Gln Asp Pro
        35                  40                  45              
Ser Phe Pro Ala Ile Pro Ser Ala Leu Gly Phe Lys Glu Leu Gly Pro
    50                  55                  60                  
Tyr Ser Ser Lys Thr Arg Gly Ile Glu Trp Lys Arg Pro Thr Glu Ile
65                  70                  75                  80  
Cys Ala Asp Pro Gln Phe Ile Ile Gly Gly Ala Thr Arg Thr Asp Ile
                85                  90                  95      
Cys Gln Gly Ala Leu Gly Asp Cys Trp Leu Leu Ala Ala Ile Ala Ser
            100                 105                 110         
Leu Thr Leu Asn Glu Glu Ile Leu Ala Arg Val Val Pro Leu Asn Gln
        115                 120                 125             
Ser Phe Gln Glu Asn Tyr Ala Gly Ile Phe His Phe Gln Phe Trp Gln
    130                 135                 140                 
Tyr Gly Glu Trp Val Glu Val Val Val Asp Asp Arg Leu Pro Thr Lys
145                 150                 155                 160 
Asp Gly Glu Leu Leu Phe Val His Ser Ala Glu Gly Ser Glu Phe Trp
                165                 170                 175     
Ser Ala Leu Leu Glu Lys Ala Tyr Ala Lys Ile Asn Gly Cys Tyr Glu
            180                 185                 190         
Ala Leu Ser Gly Gly Ala Thr Thr Glu Gly Phe Glu Asp Phe Thr Gly
        195                 200                 205             
Gly Ile Ala Glu Trp Tyr Glu Leu Lys Lys Pro Pro Pro Asn Leu Phe
    210                 215                 220                 
Lys Ile Ile Gln Lys Ala Leu Gln Lys Gly Ser Leu Leu Gly Cys Ser
225                 230                 235                 240 
Ile Asp Ile Thr Ser Ala Ala Asp Ser Glu Ala Ile Thr Phe Gln Lys
                245                 250                 255     
Leu Val Lys Gly His Ala Tyr Ser Val Thr Gly Ala Glu Glu Val Glu
            260                 265                 270         
Ser Asn Gly Ser Leu Gln Lys Leu Ile Arg Ile Arg Asn Pro Trp Gly
        275                 280                 285             
Glu Val Glu Trp Thr Gly Arg Trp Asn Asp Asn Cys Pro Ser Trp Asn
    290                 295                 300                 
Thr Ile Asp Pro Glu Glu Arg Glu Arg Leu Thr Arg Arg His Glu Asp
305                 310                 315                 320 
Gly Glu Phe Trp Met Ser Phe Ser Asp Phe Leu Arg His Tyr Ser Arg
                325                 330                 335     
Leu Glu Ile Cys Asn Leu Thr Pro Asp Thr Leu Thr Ser Asp Thr Tyr
            340                 345                 350         
Lys Lys Trp Lys Leu Thr Lys Met Asp Gly Asn Trp Arg Arg Gly Ser
        355                 360                 365             
Thr Ala Gly Gly Cys Arg Asn Tyr Pro Asn Thr Phe Trp Met Asn Pro
    370                 375                 380                 
Gln Tyr Leu Ile Lys Leu Glu Glu Glu Asp Glu Asp Glu Glu Asp Gly
385                 390                 395                 400 
Glu Ser Gly Cys Thr Phe Leu Val Gly Leu Ile Gln Lys His Arg Arg
                405                 410                 415     
Arg Gln Arg Lys Met Gly Glu Asp Met His Thr Ile Gly Phe Gly Ile
            420                 425                 430         
Tyr Glu Val Pro Glu Glu Leu Ser Gly Gln Thr Asn Ile His Leu Ser
        435                 440                 445             
Lys Asn Phe Phe Leu Thr Asn Arg Ala Arg Glu Arg Ser Asp Thr Phe
    450                 455                 460                 
Ile Asn Leu Arg Glu Val Leu Asn Arg Phe Lys Leu Pro Pro Gly Glu
465                 470                 475                 480 
Tyr Ile Leu Val Pro Ser Thr Phe Glu Pro Asn Lys Asp Gly Asp Phe
                485                 490                 495     
Cys Ile Arg Val Phe Ser Glu Lys Lys Ala Asp Tyr Gln Ala Val Asp
            500                 505                 510         
Asp Glu Ile Glu Ala Asn Leu Glu Glu Phe Asp Ile Ser Glu Asp Asp
        515                 520                 525             
Ile Asp Asp Gly Phe Arg Arg Leu Phe Ala Gln Leu Ala Gly Glu Asp
    530                 535                 540                 
Ala Glu Ile Ser Ala Phe Glu Leu Gln Thr Ile Leu Arg Arg Val Leu
545                 550                 555                 560 
Ala Lys Arg Gln Asp Ile Lys Ser Asp Gly Phe Ser Ile Glu Thr Cys
                565                 570                 575     
Lys Ile Met Val Asp Met Leu Asp Ser Asp Gly Ser Gly Lys Leu Gly
            580                 585                 590         
Leu Lys Glu Phe Tyr Ile Leu Trp Thr Lys Ile Gln Lys Tyr Gln Lys
        595                 600                 605             
Ile Tyr Arg Glu Ile Asp Val Asp Arg Ser Gly Thr Met Asn Ser Tyr
    610                 615                 620                 
Glu Met Arg Lys Ala Leu Glu Glu Ala Gly Phe Lys Met Pro Cys Gln
625                 630                 635                 640 
Leu His Gln Val Ile Val Ala Arg Phe Ala Asp Asp Gln Leu Ile Ile
                645                 650                 655     
Asp Phe Asp Asn Phe Val Arg Cys Leu Val Arg Leu Glu Thr Leu Phe
            660                 665                 670         
Lys Ile Phe Lys Gln Leu Asp Pro Glu Asn Thr Gly Thr Ile Glu Leu
        675                 680                 685             
Asp Leu Ile Ser Trp Leu Cys Phe Ser Val Leu
    690                 695                 


<210> 86
<211> 1492
<212> DNA
<213> Homo sapiens

<220> 
<223> calpain small subunit 1

<400> 86
cgggcgacag cagggccgcg gtgcagtgtc cgacccgaga gttgcggcct gagtcaccgg 60
ccccgccctc cggagccgga cgctgcggga ggcccgggag cggcagtgga accgactccc 120
agaactccgg acgtgtgcgg cgcagtgagt cgcagccatg ttcctggtta actcgttctt 180
gaagggcggc ggcggcggcg gcgggggagg cgggggcctg ggtgggggcc tgggaaatgt 240
gcttggaggc ctgatcagcg gggccggggg cggcggcggc ggcggcggcg gcggcggcgg 300
tggtggaggc ggcggtggcg gtggaacggc catgcgcatc ctaggcggag tcatcagcgc 360
catcagcgag gcggctgcgc agtacaaccc ggagcccccg cccccacgca cacattactc 420
caacattgag gccaacgaga gtgaggaggt ccggcagttc cggagactct ttgcccagct 480
ggctggagat gacatggagg tcagcgccac agaactcatg aacattctca ataaggttgt 540
gacacgacac cctgatctga agactgatgg ttttggcatt gacacatgtc gcagcatggt 600
ggccgtgatg gatagcgaca ccacaggcaa gctgggcttt gaggaattca agtacttgtg 660
gaacaacatc aaaaggtggc aggccatata caaacagttc gacactgacc gatcagggac 720
catttgcagt agtgaactcc caggtgcctt tgaggcagca gggttccacc tgaatgagca 780
tctctataac atgatcatcc gacgctactc agatgaaagt gggaacatgg attttgacaa 840
cttcatcagc tgcttggtca ggctggacgc catgttccgt gccttcaaat ctcttgacaa 900
agatggcact ggacaaatcc aggtgaacat ccaggagtgg ctgcagctga ctatgtattc 960
ctgaactgga gccccagacc cgccccctca ctgccttgct ataggagtca cctggagcct 1020
cggtctctcc cagggccgat cctgtctgca gtcacatctt tgtggggcct gctgacccac 1080
aagcttttgt tctctcagta cttgttaccc agcttctcaa catccagggc ccaatttgcc 1140
ctgcctggag ttccccctgg ctctaggaca ctctaacaag ctctgtccac gggtctcccc 1200
attcccacca ggccctgcac acacccactc cgtaacctct cccctgtacc tgtgccaagc 1260
ctagcacttg tgatgcctcc atgccccgag ggccctctct cagttctggg aggatgactc 1320
cagtccctgc acgccctggc acacccttca cggttgctac ccaggcggcc aagctccaga 1380
ccgtgccaga cccaggtgcc ccagtgcctt tgtctatatt ctgctcccag cctgccaggc 1440
ccaggaggaa ataaacatgc cccagttgct gatctctaaa aaaaaaaaaa aa         1492

<210> 87
<211> 268
<212> PRT
<213> Homo sapiens

<220> 
<223> calpain small subunit 1

<400> 87
Met Phe Leu Val Asn Ser Phe Leu Lys Gly Gly Gly Gly Gly Gly Gly
 1               5                  10                  15      
Gly Gly Gly Gly Leu Gly Gly Gly Leu Gly Asn Val Leu Gly Gly Leu
            20                  25                  30          
Ile Ser Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly
        35                  40                  45              
Gly Gly Gly Gly Gly Gly Gly Gly Thr Ala Met Arg Ile Leu Gly Gly
    50                  55                  60                  
Val Ile Ser Ala Ile Ser Glu Ala Ala Ala Gln Tyr Asn Pro Glu Pro
65                  70                  75                  80  
Pro Pro Pro Arg Thr His Tyr Ser Asn Ile Glu Ala Asn Glu Ser Glu
                85                  90                  95      
Glu Val Arg Gln Phe Arg Arg Leu Phe Ala Gln Leu Ala Gly Asp Asp
            100                 105                 110         
Met Glu Val Ser Ala Thr Glu Leu Met Asn Ile Leu Asn Lys Val Val
        115                 120                 125             
Thr Arg His Pro Asp Leu Lys Thr Asp Gly Phe Gly Ile Asp Thr Cys
    130                 135                 140                 
Arg Ser Met Val Ala Val Met Asp Ser Asp Thr Thr Gly Lys Leu Gly
145                 150                 155                 160 
Phe Glu Glu Phe Lys Tyr Leu Trp Asn Asn Ile Lys Arg Trp Gln Ala
                165                 170                 175     
Ile Tyr Lys Gln Phe Asp Thr Asp Arg Ser Gly Thr Ile Cys Ser Ser
            180                 185                 190         
Glu Leu Pro Gly Ala Phe Glu Ala Ala Gly Phe His Leu Asn Glu His
        195                 200                 205             
Leu Tyr Asn Met Ile Ile Arg Arg Tyr Ser Asp Glu Ser Gly Asn Met
    210                 215                 220                 
Asp Phe Asp Asn Phe Ile Ser Cys Leu Val Arg Leu Asp Ala Met Phe
225                 230                 235                 240 
Arg Ala Phe Lys Ser Leu Asp Lys Asp Gly Thr Gly Gln Ile Gln Val
                245                 250                 255     
Asn Ile Gln Glu Trp Leu Gln Leu Thr Met Tyr Ser
            260                 265             


<210> 88
<211> 2205
<212> DNA
<213> Homo sapiens

<220> 
<223> cathepsin D precursor

<400> 88
gcgcacgccg gccgcgccca cgtgaccggt ccgggtgcaa acacgcgggt cagctgatcc 60
ggcccaactg cggcgtcatc ccggctataa gcgcacggcc tcggcgaccc tctccgaccc 120
ggccgccgcc gccatgcagc cctccagcct tctgccgctc gccctctgcc tgctggctgc 180
acccgcctcc gcgctcgtca ggatcccgct gcacaagttc acgtccatcc gccggaccat 240
gtcggaggtt gggggctctg tggaggacct gattgccaaa ggccccgtct caaagtactc 300
ccaggcggtg ccagccgtga ccgaggggcc cattcccgag gtgctcaaga actacatgga 360
cgcccagtac tacggggaga ttggcatcgg gacgcccccc cagtgcttca cagtcgtctt 420
cgacacgggc tcctccaacc tgtgggtccc ctccatccac tgcaaactgc tggacatcgc 480
ttgctggatc caccacaagt acaacagcga caagtccagc acctacgtga agaatggtac 540
ctcgtttgac atccactatg gctcgggcag cctctccggg tacctgagcc aggacactgt 600
gtcggtgccc tgccagtcag cgtcgtcagc ctctgccctg ggcggtgtca aagtggagag 660
gcaggtcttt ggggaggcca ccaagcagcc aggcatcacc ttcatcgcag ccaagttcga 720
tggcatcctg ggcatggcct acccccgcat ctccgtcaac aacgtgctgc ccgtcttcga 780
caacctgatg cagcagaagc tggtggacca gaacatcttc tccttctacc tgagcaggga 840
cccagatgcg cagcctgggg gtgagctgat gctgggtggc acagactcca agtattacaa 900
gggttctctg tcctacctga atgtcacccg caaggcctac tggcaggtcc acctggacca 960
ggtggaggtg gccagcgggc tgaccctgtg caaggagggc tgtgaggcca ttgtggacac 1020
aggcacttcc ctcatggtgg gcccggtgga tgaggtgcgc gagctgcaga aggccatcgg 1080
ggccgtgccg ctgattcagg gcgagtacat gatcccctgt gagaaggtgt ccaccctgcc 1140
cgcgatcaca ctgaagctgg gaggcaaagg ctacaagctg tccccagagg actacacgct 1200
caaggtgtcg caggccggga agaccctctg cctgagcggc ttcatgggca tggacatccc 1260
gccacccagc gggccactct ggatcctggg cgacgtcttc atcggccgct actacactgt 1320
gtttgaccgt gacaacaaca gggtgggctt cgccgaggct gcccgcctct agttcccaag 1380
gcgtccgcgc gccagcacag aaacagagga gagtcccaga gcaggaggcc cctggcccag 1440
cggcccctcc cacacacacc cacacactcg cccgcccact gtcctgggcg ccctggaagc 1500
cggcggccca agcccgactt gctgttttgt tctgtggttt tcccctccct gggttcagaa 1560
atgctgcctg cctgtctgtc tctccatctg tttggtgggg gtagagctga tccagagcac 1620
agatctgttt cgtgcattgg aagaccccac ccaagcttgg cagccgagct cgtgtatcct 1680
ggggctccct tcatctccag ggagtcccct ccccggccct accagcgccc gctgggctga 1740
gcccctaccc cacaccaggc cgtcctcccg ggccctccct tggaaacctg ccctgcctga 1800
gggcccctct gcccagcttg ggcccagctg ggctctgcca ccctacctgt tcagtgtccc 1860
gggcccgttg aggatgaggc cgctagaggc ctgaggatga gctggaagga gtgagagggg 1920
acaaaaccca ccttgttgga gcctgcaggg tggtgctggg actgagccag tcccaggggc 1980
atgtattggc ctggaggtgg ggttgggatt gggggctggt gccagccttc ctctgcagct 2040
gacctctgtt gtcctcccct tgggcggctg agagccccag ctgacatgga aatacagttg 2100
ttggcctccg gcctcccctc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2160
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                 2205

<210> 89
<211> 412
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin D precursor

<400> 89
Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala
 1               5                  10                  15      
Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile
            20                  25                  30          
Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala
        35                  40                  45              
Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu
    50                  55                  60                  
Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr
65                  70                  75                  80  
Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe
                85                  90                  95      
Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu
            100                 105                 110         
Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser
        115                 120                 125             
Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser
    130                 135                 140                 
Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys
145                 150                 155                 160 
Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg
                165                 170                 175     
Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala
            180                 185                 190         
Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val
        195                 200                 205             
Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val
    210                 215                 220                 
Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln
225                 230                 235                 240 
Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys
                245                 250                 255     
Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val
            260                 265                 270         
His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu
        275                 280                 285             
Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro
    290                 295                 300                 
Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu
305                 310                 315                 320 
Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro
                325                 330                 335     
Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu
            340                 345                 350         
Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser
        355                 360                 365             
Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile
    370                 375                 380                 
Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp
385                 390                 395                 400 
Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu
                405                 410         


<210> 90
<211> 348
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin D mature

<400> 90
Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr
 1               5                  10                  15      
Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe
            20                  25                  30          
Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu
        35                  40                  45              
Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser
    50                  55                  60                  
Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser
65                  70                  75                  80  
Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys
                85                  90                  95      
Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg
            100                 105                 110         
Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala
        115                 120                 125             
Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val
    130                 135                 140                 
Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val
145                 150                 155                 160 
Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln
                165                 170                 175     
Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys
            180                 185                 190         
Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val
        195                 200                 205             
His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu
    210                 215                 220                 
Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro
225                 230                 235                 240 
Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu
                245                 250                 255     
Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro
            260                 265                 270         
Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu
        275                 280                 285             
Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser
    290                 295                 300                 
Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile
305                 310                 315                 320 
Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp
                325                 330                 335     
Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu
            340                 345             


<210> 91
<211> 2228
<212> DNA
<213> Homo sapiens

<220> 
<223> cathepsin e transcript variant 1

<400> 91
atcattcggc cctcagactg ggctgggcag gtctgagagt tagggaaagt ccgttcccac 60
tgccctcggg gagagaagaa aggagggggc aagggagaag ctgctggtcg gactcacaat 120
gaaaacgctc cttcttttgc tgctggtgct cctggagctg ggagaggccc aaggatccct 180
tcacagggtg cccctcagga ggcatccgtc cctcaagaag aagctgcggg cacggagcca 240
gctctctgag ttctggaaat cccataattt ggacatgatc cagttcaccg agtcctgctc 300
aatggaccag agtgccaagg aacccctcat caactacttg gatatggaat acttcggcac 360
tatctccatt ggctccccac cacagaactt cactgtcatc ttcgacactg gctcctccaa 420
cctctgggtc ccctctgtgt actgcactag cccagcctgc aagacgcaca gcaggttcca 480
gccttcccag tccagcacat acagccagcc aggtcaatct ttctccattc agtatggaac 540
cgggagcttg tccgggatca ttggagccga ccaagtctct gtggaaggac taaccgtggt 600
tggccagcag tttggagaaa gtgtcacaga gccaggccag acctttgtgg atgcagagtt 660
tgatggaatt ctgggcctgg gatacccctc cttggctgtg ggaggagtga ctccagtatt 720
tgacaacatg atggctcaga acctggtgga cttgccgatg ttttctgtct acatgagcag 780
taacccagaa ggtggtgcgg ggagcgagct gatttttgga ggctacgacc actcccattt 840
ctctgggagc ctgaattggg tcccagtcac caagcaagct tactggcaga ttgcactgga 900
taacatccag gtgggaggca ctgttatgtt ctgctccgag ggctgccagg ccattgtgga 960
cacagggact tccctcatca ctggcccttc cgacaagatt aagcagctgc aaaacgccat 1020
tggggcagcc cccgtggatg gagaatatgc tgtggagtgt gccaacctta acgtcatgcc 1080
ggatgtcacc ttcaccatta acggagtccc ctataccctc agcccaactg cctacaccct 1140
actggacttc gtggatggaa tgcagttctg cagcagtggc tttcaaggac ttgacatcca 1200
ccctccagct gggcccctct ggatcctggg ggatgtcttc attcgacagt tttactcagt 1260
ctttgaccgt gggaataacc gtgtgggact ggccccagca gtcccctaag gaggggcctt 1320
gtgtctgtgc ctgcctgtct gacagacctt gaatatgtta ggctggggca ttctttacac 1380
ctacaaaaag ttattttcca gagaatgtag ctgtttccag ggttgcaact tgaattaaga 1440
ccaaacagaa catgagaata cacacacaca cacacatata cacacacaca cacttcacac 1500
atacacacca ctcccaccac cgtcatgatg gaggaattac gttatacatt catattttgt 1560
attgattttt gattatgaaa atcaaaaatt ttcacatttg attatgaaaa tctccaaaca 1620
tatgcacaag cagagatcat ggtataataa atccctttgc aactccactc agccctgaca 1680
acccatccac acacggccag gcctgtttat ctacactgct gcccactcct ctctccagct 1740
ccacatgctg tacctggatc attctgaagc aaattccgag cattacatca ttttgtccat 1800
aaatatttct aacatcctta aatatacaat cggaattcaa gcatctccca ttgtcccaca 1860
aatgtttggc tgtttttgta gttggattgt ttgtattagg attcaagcaa ggcccatata 1920
ttgcatttat ttgaaatgtc tgtaagtctc tttccatcta cagagtttag cacatttgaa 1980
cgttgctggt tgaaatcccg aggtgtcatt tgacatggtt ctctgaactt atctttccta 2040
taaaatggta gttagatctg gaggtctgat tttgtggcaa aaatacttcc taggtggtgc 2100
tgggtacttc ttgttgcatc ctgtcaggag gcagataatg ctggtgcctc tctattggta 2160
atgttaagac tgctgggtgg gtttggagtt cttggcttta atcattcatt acaaagttca 2220
gcatttta                                                          2228

<210> 92
<211> 396
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin E isoform a precursor

<400> 92
Met Lys Thr Leu Leu Leu Leu Leu Leu Val Leu Leu Glu Leu Gly Glu
 1               5                  10                  15      
Ala Gln Gly Ser Leu His Arg Val Pro Leu Arg Arg His Pro Ser Leu
            20                  25                  30          
Lys Lys Lys Leu Arg Ala Arg Ser Gln Leu Ser Glu Phe Trp Lys Ser
        35                  40                  45              
His Asn Leu Asp Met Ile Gln Phe Thr Glu Ser Cys Ser Met Asp Gln
    50                  55                  60                  
Ser Ala Lys Glu Pro Leu Ile Asn Tyr Leu Asp Met Glu Tyr Phe Gly
65                  70                  75                  80  
Thr Ile Ser Ile Gly Ser Pro Pro Gln Asn Phe Thr Val Ile Phe Asp
                85                  90                  95      
Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Val Tyr Cys Thr Ser Pro
            100                 105                 110         
Ala Cys Lys Thr His Ser Arg Phe Gln Pro Ser Gln Ser Ser Thr Tyr
        115                 120                 125             
Ser Gln Pro Gly Gln Ser Phe Ser Ile Gln Tyr Gly Thr Gly Ser Leu
    130                 135                 140                 
Ser Gly Ile Ile Gly Ala Asp Gln Val Ser Val Glu Gly Leu Thr Val
145                 150                 155                 160 
Val Gly Gln Gln Phe Gly Glu Ser Val Thr Glu Pro Gly Gln Thr Phe
                165                 170                 175     
Val Asp Ala Glu Phe Asp Gly Ile Leu Gly Leu Gly Tyr Pro Ser Leu
            180                 185                 190         
Ala Val Gly Gly Val Thr Pro Val Phe Asp Asn Met Met Ala Gln Asn
        195                 200                 205             
Leu Val Asp Leu Pro Met Phe Ser Val Tyr Met Ser Ser Asn Pro Glu
    210                 215                 220                 
Gly Gly Ala Gly Ser Glu Leu Ile Phe Gly Gly Tyr Asp His Ser His
225                 230                 235                 240 
Phe Ser Gly Ser Leu Asn Trp Val Pro Val Thr Lys Gln Ala Tyr Trp
                245                 250                 255     
Gln Ile Ala Leu Asp Asn Ile Gln Val Gly Gly Thr Val Met Phe Cys
            260                 265                 270         
Ser Glu Gly Cys Gln Ala Ile Val Asp Thr Gly Thr Ser Leu Ile Thr
        275                 280                 285             
Gly Pro Ser Asp Lys Ile Lys Gln Leu Gln Asn Ala Ile Gly Ala Ala
    290                 295                 300                 
Pro Val Asp Gly Glu Tyr Ala Val Glu Cys Ala Asn Leu Asn Val Met
305                 310                 315                 320 
Pro Asp Val Thr Phe Thr Ile Asn Gly Val Pro Tyr Thr Leu Ser Pro
                325                 330                 335     
Thr Ala Tyr Thr Leu Leu Asp Phe Val Asp Gly Met Gln Phe Cys Ser
            340                 345                 350         
Ser Gly Phe Gln Gly Leu Asp Ile His Pro Pro Ala Gly Pro Leu Trp
        355                 360                 365             
Ile Leu Gly Asp Val Phe Ile Arg Gln Phe Tyr Ser Val Phe Asp Arg
    370                 375                 380                 
Gly Asn Asn Arg Val Gly Leu Ala Pro Ala Val Pro
385                 390                 395     


<210> 93
<211> 343
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin E isoform a mature

<400> 93
Ile Gln Phe Thr Glu Ser Cys Ser Met Asp Gln Ser Ala Lys Glu Pro
 1               5                  10                  15      
Leu Ile Asn Tyr Leu Asp Met Glu Tyr Phe Gly Thr Ile Ser Ile Gly
            20                  25                  30          
Ser Pro Pro Gln Asn Phe Thr Val Ile Phe Asp Thr Gly Ser Ser Asn
        35                  40                  45              
Leu Trp Val Pro Ser Val Tyr Cys Thr Ser Pro Ala Cys Lys Thr His
    50                  55                  60                  
Ser Arg Phe Gln Pro Ser Gln Ser Ser Thr Tyr Ser Gln Pro Gly Gln
65                  70                  75                  80  
Ser Phe Ser Ile Gln Tyr Gly Thr Gly Ser Leu Ser Gly Ile Ile Gly
                85                  90                  95      
Ala Asp Gln Val Ser Val Glu Gly Leu Thr Val Val Gly Gln Gln Phe
            100                 105                 110         
Gly Glu Ser Val Thr Glu Pro Gly Gln Thr Phe Val Asp Ala Glu Phe
        115                 120                 125             
Asp Gly Ile Leu Gly Leu Gly Tyr Pro Ser Leu Ala Val Gly Gly Val
    130                 135                 140                 
Thr Pro Val Phe Asp Asn Met Met Ala Gln Asn Leu Val Asp Leu Pro
145                 150                 155                 160 
Met Phe Ser Val Tyr Met Ser Ser Asn Pro Glu Gly Gly Ala Gly Ser
                165                 170                 175     
Glu Leu Ile Phe Gly Gly Tyr Asp His Ser His Phe Ser Gly Ser Leu
            180                 185                 190         
Asn Trp Val Pro Val Thr Lys Gln Ala Tyr Trp Gln Ile Ala Leu Asp
        195                 200                 205             
Asn Ile Gln Val Gly Gly Thr Val Met Phe Cys Ser Glu Gly Cys Gln
    210                 215                 220                 
Ala Ile Val Asp Thr Gly Thr Ser Leu Ile Thr Gly Pro Ser Asp Lys
225                 230                 235                 240 
Ile Lys Gln Leu Gln Asn Ala Ile Gly Ala Ala Pro Val Asp Gly Glu
                245                 250                 255     
Tyr Ala Val Glu Cys Ala Asn Leu Asn Val Met Pro Asp Val Thr Phe
            260                 265                 270         
Thr Ile Asn Gly Val Pro Tyr Thr Leu Ser Pro Thr Ala Tyr Thr Leu
        275                 280                 285             
Leu Asp Phe Val Asp Gly Met Gln Phe Cys Ser Ser Gly Phe Gln Gly
    290                 295                 300                 
Leu Asp Ile His Pro Pro Ala Gly Pro Leu Trp Ile Leu Gly Asp Val
305                 310                 315                 320 
Phe Ile Arg Gln Phe Tyr Ser Val Phe Asp Arg Gly Asn Asn Arg Val
                325                 330                 335     
Gly Leu Ala Pro Ala Val Pro
            340             


<210> 94
<211> 2086
<212> DNA
<213> Homo sapiens

<220> 
<223> cathepsin E  transcript variant 2

<400> 94
atcattcggc cctcagactg ggctgggcag gtctgagagt tagggaaagt ccgttcccac 60
tgccctcggg gagagaagaa aggagggggc aagggagaag ctgctggtcg gactcacaat 120
gaaaacgctc cttcttttgc tgctggtgct cctggagctg ggagaggccc aaggatccct 180
tcacagggtg cccctcagga ggcatccgtc cctcaagaag aagctgcggg cacggagcca 240
gctctctgag ttctggaaat cccataattt ggacatgatc cagttcaccg agtcctgctc 300
aatggaccag agtgccaagg aacccctcat caactacttg gatatggaat acttcggcac 360
tatctccatt ggctccccac cacagaactt cactgtcatc ttcgacactg gctcctccaa 420
cctctgggtc ccctctgtgt actgcactag cccagcctgc aagacgcaca gcaggttcca 480
gccttcccag tccagcacat acagccagcc aggtcaatct ttctccattc agtatggaac 540
cgggagcttg tccgggatca ttggagccga ccaagtctct gtggaaggac taaccgtggt 600
tggccagcag tttggagaaa gtgtcacaga gccaggccag acctttgtgg atgcagagtt 660
tgatggaatt ctgggcctgg gatacccctc cttggctgtg ggaggagtga ctccagtatt 720
tgacaacatg atggctcaga acctggtgga cttgccgatg ttttctgtct acatgagcag 780
taacccagaa ggtggtgcgg ggagcgagct gatttttgga ggctacgacc actcccattt 840
ctctgggagc ctgaattggg tcccagtcac caagcaagct tactggcaga ttgcactgga 900
taatatgctg tggagtgtgc caaccttaac gtcatgccgg atgtcacctt caccattaac 960
ggagtcccct ataccctcag cccaactgcc tacaccctac tggacttcgt ggatggaatg 1020
cagttctgca gcagtggctt tcaaggactt gacatccacc ctccagctgg gcccctctgg 1080
atcctggggg atgtcttcat tcgacagttt tactcagtct ttgaccgtgg gaataaccgt 1140
gtgggactgg ccccagcagt cccctaagga ggggccttgt gtctgtgcct gcctgtctga 1200
cagaccttga atatgttagg ctggggcatt ctttacacct acaaaaagtt attttccaga 1260
gaatgtagct gtttccaggg ttgcaacttg aattaagacc aaacagaaca tgagaataca 1320
cacacacaca cacatataca cacacacaca cttcacacat acacaccact cccaccaccg 1380
tcatgatgga ggaattacgt tatacattca tattttgtat tgatttttga ttatgaaaat 1440
caaaaatttt cacatttgat tatgaaaatc tccaaacata tgcacaagca gagatcatgg 1500
tataataaat ccctttgcaa ctccactcag ccctgacaac ccatccacac acggccaggc 1560
ctgtttatct acactgctgc ccactcctct ctccagctcc acatgctgta cctggatcat 1620
tctgaagcaa attccgagca ttacatcatt ttgtccataa atatttctaa catccttaaa 1680
tatacaatcg gaattcaagc atctcccatt gtcccacaaa tgtttggctg tttttgtagt 1740
tggattgttt gtattaggat tcaagcaagg cccatatatt gcatttattt gaaatgtctg 1800
taagtctctt tccatctaca gagtttagca catttgaacg ttgctggttg aaatcccgag 1860
gtgtcatttg acatggttct ctgaacttat ctttcctata aaatggtagt tagatctgga 1920
ggtctgattt tgtggcaaaa atacttccta ggtggtgctg ggtacttctt gttgcatcct 1980
gtcaggaggc agataatgct ggtgcctctc tattggtaat gttaagactg ctgggtgggt 2040
ttggagttct tggctttaat cattcattac aaagttcagc atttta                2086

<210> 95
<211> 363
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin E isoform B precursor

<400> 95
Met Lys Thr Leu Leu Leu Leu Leu Leu Val Leu Leu Glu Leu Gly Glu
 1               5                  10                  15      
Ala Gln Gly Ser Leu His Arg Val Pro Leu Arg Arg His Pro Ser Leu
            20                  25                  30          
Lys Lys Lys Leu Arg Ala Arg Ser Gln Leu Ser Glu Phe Trp Lys Ser
        35                  40                  45              
His Asn Leu Asp Met Ile Gln Phe Thr Glu Ser Cys Ser Met Asp Gln
    50                  55                  60                  
Ser Ala Lys Glu Pro Leu Ile Asn Tyr Leu Asp Met Glu Tyr Phe Gly
65                  70                  75                  80  
Thr Ile Ser Ile Gly Ser Pro Pro Gln Asn Phe Thr Val Ile Phe Asp
                85                  90                  95      
Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Val Tyr Cys Thr Ser Pro
            100                 105                 110         
Ala Cys Lys Thr His Ser Arg Phe Gln Pro Ser Gln Ser Ser Thr Tyr
        115                 120                 125             
Ser Gln Pro Gly Gln Ser Phe Ser Ile Gln Tyr Gly Thr Gly Ser Leu
    130                 135                 140                 
Ser Gly Ile Ile Gly Ala Asp Gln Val Ser Val Glu Gly Leu Thr Val
145                 150                 155                 160 
Val Gly Gln Gln Phe Gly Glu Ser Val Thr Glu Pro Gly Gln Thr Phe
                165                 170                 175     
Val Asp Ala Glu Phe Asp Gly Ile Leu Gly Leu Gly Tyr Pro Ser Leu
            180                 185                 190         
Ala Val Gly Gly Val Thr Pro Val Phe Asp Asn Met Met Ala Gln Asn
        195                 200                 205             
Leu Val Asp Leu Pro Met Phe Ser Val Tyr Met Ser Ser Asn Pro Glu
    210                 215                 220                 
Gly Gly Ala Gly Ser Glu Leu Ile Phe Gly Gly Tyr Asp His Ser His
225                 230                 235                 240 
Phe Ser Gly Ser Leu Asn Trp Val Pro Val Thr Lys Gln Ala Tyr Trp
                245                 250                 255     
Gln Ile Ala Leu Asp Asn Met Leu Trp Ser Val Pro Thr Leu Thr Ser
            260                 265                 270         
Cys Arg Met Ser Pro Ser Pro Leu Thr Glu Ser Pro Ile Pro Ser Ala
        275                 280                 285             
Gln Leu Pro Thr Pro Tyr Trp Thr Ser Trp Met Glu Cys Ser Ser Ala
    290                 295                 300                 
Ala Val Ala Phe Lys Asp Leu Thr Ser Thr Leu Gln Leu Gly Pro Ser
305                 310                 315                 320 
Gly Ser Trp Gly Met Ser Ser Phe Asp Ser Phe Thr Gln Ser Leu Thr
                325                 330                 335     
Val Gly Ile Thr Val Trp Asp Trp Pro Gln Gln Ser Pro Lys Glu Gly
            340                 345                 350         
Pro Cys Val Cys Ala Cys Leu Ser Asp Arg Pro
        355                 360             


<210> 96
<211> 310
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin E isoform b mature

<400> 96
Ile Gln Phe Thr Glu Ser Cys Ser Met Asp Gln Ser Ala Lys Glu Pro
 1               5                  10                  15      
Leu Ile Asn Tyr Leu Asp Met Glu Tyr Phe Gly Thr Ile Ser Ile Gly
            20                  25                  30          
Ser Pro Pro Gln Asn Phe Thr Val Ile Phe Asp Thr Gly Ser Ser Asn
        35                  40                  45              
Leu Trp Val Pro Ser Val Tyr Cys Thr Ser Pro Ala Cys Lys Thr His
    50                  55                  60                  
Ser Arg Phe Gln Pro Ser Gln Ser Ser Thr Tyr Ser Gln Pro Gly Gln
65                  70                  75                  80  
Ser Phe Ser Ile Gln Tyr Gly Thr Gly Ser Leu Ser Gly Ile Ile Gly
                85                  90                  95      
Ala Asp Gln Val Ser Val Glu Gly Leu Thr Val Val Gly Gln Gln Phe
            100                 105                 110         
Gly Glu Ser Val Thr Glu Pro Gly Gln Thr Phe Val Asp Ala Glu Phe
        115                 120                 125             
Asp Gly Ile Leu Gly Leu Gly Tyr Pro Ser Leu Ala Val Gly Gly Val
    130                 135                 140                 
Thr Pro Val Phe Asp Asn Met Met Ala Gln Asn Leu Val Asp Leu Pro
145                 150                 155                 160 
Met Phe Ser Val Tyr Met Ser Ser Asn Pro Glu Gly Gly Ala Gly Ser
                165                 170                 175     
Glu Leu Ile Phe Gly Gly Tyr Asp His Ser His Phe Ser Gly Ser Leu
            180                 185                 190         
Asn Trp Val Pro Val Thr Lys Gln Ala Tyr Trp Gln Ile Ala Leu Asp
        195                 200                 205             
Asn Met Leu Trp Ser Val Pro Thr Leu Thr Ser Cys Arg Met Ser Pro
    210                 215                 220                 
Ser Pro Leu Thr Glu Ser Pro Ile Pro Ser Ala Gln Leu Pro Thr Pro
225                 230                 235                 240 
Tyr Trp Thr Ser Trp Met Glu Cys Ser Ser Ala Ala Val Ala Phe Lys
                245                 250                 255     
Asp Leu Thr Ser Thr Leu Gln Leu Gly Pro Ser Gly Ser Trp Gly Met
            260                 265                 270         
Ser Ser Phe Asp Ser Phe Thr Gln Ser Leu Thr Val Gly Ile Thr Val
        275                 280                 285             
Trp Asp Trp Pro Gln Gln Ser Pro Lys Glu Gly Pro Cys Val Cys Ala
    290                 295                 300                 
Cys Leu Ser Asp Arg Pro
305                 310 


<210> 97
<211> 1973
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-1 precursor

<400> 97
gggatattgg agtagcaaga ggctgggaag ccatcactta ccttgcactg agaaagaaga 60
caaaggccag tatgcacagc tttcctccac tgctgctgct gctgttctgg ggtgtggtgt 120
ctcacagctt cccagcgact ctagaaacac aagagcaaga tgtggactta gtccagaaat 180
acctggaaaa atactacaac ctgaagaatg atgggaggca agttgaaaag cggagaaata 240
gtggcccagt ggttgaaaaa ttgaagcaaa tgcaggaatt ctttgggctg aaagtgactg 300
ggaaaccaga tgctgaaacc ctgaaggtga tgaagcagcc cagatgtgga gtgcctgatg 360
tggctcagtt tgtcctcact gaggggaacc ctcgctggga gcaaacacat ctgacctaca 420
ggattgaaaa ttacacgcca gatttgccaa gagcagatgt ggaccatgcc attgagaaag 480
ccttccaact ctggagtaat gtcacacctc tgacattcac caaggtctct gagggtcaag 540
cagacatcat gatatctttt gtcaggggag atcatcggga caactctcct tttgatggac 600
ctggaggaaa tcttgctcat gcttttcaac caggcccagg tattggaggg gatgctcatt 660
ttgatgaaga tgaaaggtgg accaacaatt tcagagagta caacttacat cgtgttgcgg 720
ctcatgaact cggccattct cttggactct cccattctac tgatatcggg gctttgatgt 780
accctagcta caccttcagt ggtgatgttc agctagctca ggatgacatt gatggcatcc 840
aagccatata tggacgttcc caaaatcctg tccagcccat cggcccacaa accccaaaag 900
cgtgtgacag taagctaacc tttgatgcta taactacgat tcggggagaa gtgatgttct 960
ttaaagacag attctacatg cgcacaaatc ccttctaccc ggaagttgag ctcaatttca 1020
tttctgtttt ctggccacaa ctgccaaatg ggcttgaagc tgcttacgaa tttgccgaca 1080
gagatgaagt ccggtttttc aaagggaata agtactgggc tgttcaggga cagaatgtgc 1140
tacacggata ccccaaggac atctacagct cctttggctt ccctagaact gtgaagcata 1200
tcgatgctgc tctttctgag gaaaacactg gaaaaaccta cttctttgtt gctaacaaat 1260
actggaggta tgatgaatat aaacgatcta tggatccagg ttatcccaaa atgatagcac 1320
atgactttcc tggaattggc cacaaagttg atgcagtttt catgaaagat ggatttttct 1380
atttctttca tggaacaaga caatacaaat ttgatcctaa aacgaagaga attttgactc 1440
tccagaaagc taatagctgg ttcaactgca ggaaaaattg aacattacta atttgaatgg 1500
aaaacacatg gtgtgagtcc aaagaaggtg ttttcctgaa gaactgtcta ttttctcagt 1560
catttttaac ctctagagtc actgatacac agaatataat cttatttata cctcagtttg 1620
catatttttt tactatttag aatgtagccc tttttgtact gatataattt agttccacaa 1680
atggtgggta caaaaagtca agtttgtggc ttatggattc atataggcca gagttgcaaa 1740
gatcttttcc agagtatgca actctgacgt tgatcccaga gagcagcttc agtgacaaac 1800
atatcctttc aagacagaaa gagacaggag acatgagtct ttgccggagg aaaagcagct 1860
caagaacaca tgtgcagtca ctggtgtcac cctggatagg caagggataa ctcttctaac 1920
acaaaataag tgttttatgt ttggaataaa gtcaaccttg tttctactgt ttt        1973

<210> 98
<211> 469
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-1 precursor

<400> 98
Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val
 1               5                  10                  15      
Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp
            20                  25                  30          
Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly
        35                  40                  45              
Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu
    50                  55                  60                  
Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp
65                  70                  75                  80  
Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp
                85                  90                  95      
Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr
            100                 105                 110         
His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala
        115                 120                 125             
Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val
    130                 135                 140                 
Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met
145                 150                 155                 160 
Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly
                165                 170                 175     
Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly
            180                 185                 190         
Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg
        195                 200                 205             
Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu
    210                 215                 220                 
Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr
225                 230                 235                 240 
Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile
                245                 250                 255     
Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro
            260                 265                 270         
Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr
        275                 280                 285             
Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg
    290                 295                 300                 
Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe
305                 310                 315                 320 
Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp
                325                 330                 335     
Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln
            340                 345                 350         
Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe
        355                 360                 365             
Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu
    370                 375                 380                 
Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr
385                 390                 395                 400 
Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala
                405                 410                 415     
His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys
            420                 425                 430         
Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp
        435                 440                 445             
Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe
    450                 455                 460                 
Asn Cys Arg Lys Asn
465                 


<210> 99
<211> 370
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-1 mature

<400> 99
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
 1               5                  10                  15      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            20                  25                  30          
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        35                  40                  45              
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    50                  55                  60                  
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
65                  70                  75                  80  
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                85                  90                  95      
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            100                 105                 110         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        115                 120                 125             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    130                 135                 140                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
145                 150                 155                 160 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                165                 170                 175     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            180                 185                 190         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        195                 200                 205             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    210                 215                 220                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
225                 230                 235                 240 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                245                 250                 255     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            260                 265                 270         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        275                 280                 285             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    290                 295                 300                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
305                 310                 315                 320 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                325                 330                 335     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            340                 345                 350         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        355                 360                 365             
Lys Asn
    370 


<210> 100
<211> 2223
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-8 precursor

<400> 100
gctcgccagg gaagggccct acccagagga cagaaagaaa gccaggaggg gtagagtttg 60
aagagaagat catgttctcc ctgaagacgc ttccatttct gctcttactc catgtgcaga 120
tttccaaggc ctttcctgta tcttctaaag agaaaaatac aaaaactgtt caggactacc 180
tggaaaagtt ctaccaatta ccaagcaacc agtatcagtc tacaaggaag aatggcacta 240
atgtgatcgt tgaaaagctt aaagaaatgc agcgattttt tgggttgaat gtgacgggga 300
agccaaatga ggaaactctg gacatgatga aaaagcctcg ctgtggagtg cctgacagtg 360
gtggttttat gttaacccca ggaaacccca agtgggaacg cactaacttg acctacagga 420
ttcgaaacta taccccacag ctgtcagagg ctgaggtaga aagagctatc aaggatgcct 480
ttgaactctg gagtgttgca tcacctctca tcttcaccag gatctcacag ggagaggcag 540
atatcaacat tgctttttac caaagagatc acggtgacaa ttctccattt gatggaccca 600
atggaatcct tgctcatgcc tttcagccag gccaaggtat tggaggagat gctcattttg 660
atgccgaaga aacatggacc aacacctccg caaattacaa cttgtttctt gttgctgctc 720
atgaatttgg ccattctttg gggctcgctc actcctctga ccctggtgcc ttgatgtatc 780
ccaactatgc tttcagggaa accagcaact actcactccc tcaagatgac atcgatggca 840
ttcaggccat ctatggactt tcaagcaacc ctatccaacc tactggacca agcacaccca 900
aaccctgtga ccccagtttg acatttgatg ctatcaccac actccgtgga gaaatacttt 960
tctttaaaga caggtacttc tggagaaggc atcctcagct acaaagagtc gaaatgaatt 1020
ttatttctct attctggcca tcccttccaa ctggtataca ggctgcttat gaagattttg 1080
acagagacct cattttccta tttaaaggca accaatactg ggctctgagt ggctatgata 1140
ttctgcaagg ttatcccaag gatatatcaa actatggctt ccccagcagc gtccaagcaa 1200
ttgacgcagc tgttttctac agaagtaaaa catacttctt tgtaaatgac caattctgga 1260
gatatgataa ccaaagacaa ttcatggagc caggttatcc caaaagcata tcaggtgcct 1320
ttccaggaat agagagtaaa gttgatgcag ttttccagca agaacatttc ttccatgtct 1380
tcagtggacc aagatattac gcatttgatc ttattgctca gagagttacc agagttgcaa 1440
gaggcaataa atggcttaac tgtagatatg gctgaagcaa aatcaaatgt ggctgtatcc 1500
actttcagaa tgttgaaggg aagttcagca tgcattttcg ttacattgtg tcctgcttat 1560
acttttctca atattaagtc attgtttccc atcactgtat ccattctacc tgtcctccgt 1620
gaaaatatgt ttggaatatt ccactatttg cagaggctta ttcagttctt acacattcca 1680
tcttacatta gtgattccat caaagagaag gaaagtaagc ctttttgtca cctcaatatt 1740
tactatttca atacttacat atctgacttc taggatttat tgttatatta cttgcctatc 1800
tgacttcata catccctcag tttcttaaaa tgtcctatgt atatcttcta catgcaattt 1860
agaactagat tttggttaga agtaaggatt ataaacaacc tagacagtac ccttggcctt 1920
tacagaaaat atggtgctgt tttctaccct tggaaagaaa tgtagatgat atgtttcgtg 1980
ggttgaattg tgtcccccat aaaagatatg ttgaagttct aaccccaggt acccatgaat 2040
gtgagcttac cagggtcttt gcagatgtaa ttagttaagt taaggtgaga tcacactgaa 2100
ttagggtggg ctctaaatcc attatgactg ttgttcttat aagaagaaga gagcatagcc 2160
acctagggga ggaggccgtg tgaagacaga ggcagagatt ggagtgacgc atctccaagc 2220
caa                                                               2223

<210> 101
<211> 467
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-8 precursor

<400> 101
Met Phe Ser Leu Lys Thr Leu Pro Phe Leu Leu Leu Leu His Val Gln
 1               5                  10                  15      
Ile Ser Lys Ala Phe Pro Val Ser Ser Lys Glu Lys Asn Thr Lys Thr
            20                  25                  30          
Val Gln Asp Tyr Leu Glu Lys Phe Tyr Gln Leu Pro Ser Asn Gln Tyr
        35                  40                  45              
Gln Ser Thr Arg Lys Asn Gly Thr Asn Val Ile Val Glu Lys Leu Lys
    50                  55                  60                  
Glu Met Gln Arg Phe Phe Gly Leu Asn Val Thr Gly Lys Pro Asn Glu
65                  70                  75                  80  
Glu Thr Leu Asp Met Met Lys Lys Pro Arg Cys Gly Val Pro Asp Ser
                85                  90                  95      
Gly Gly Phe Met Leu Thr Pro Gly Asn Pro Lys Trp Glu Arg Thr Asn
            100                 105                 110         
Leu Thr Tyr Arg Ile Arg Asn Tyr Thr Pro Gln Leu Ser Glu Ala Glu
        115                 120                 125             
Val Glu Arg Ala Ile Lys Asp Ala Phe Glu Leu Trp Ser Val Ala Ser
    130                 135                 140                 
Pro Leu Ile Phe Thr Arg Ile Ser Gln Gly Glu Ala Asp Ile Asn Ile
145                 150                 155                 160 
Ala Phe Tyr Gln Arg Asp His Gly Asp Asn Ser Pro Phe Asp Gly Pro
                165                 170                 175     
Asn Gly Ile Leu Ala His Ala Phe Gln Pro Gly Gln Gly Ile Gly Gly
            180                 185                 190         
Asp Ala His Phe Asp Ala Glu Glu Thr Trp Thr Asn Thr Ser Ala Asn
        195                 200                 205             
Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ser Leu Gly
    210                 215                 220                 
Leu Ala His Ser Ser Asp Pro Gly Ala Leu Met Tyr Pro Asn Tyr Ala
225                 230                 235                 240 
Phe Arg Glu Thr Ser Asn Tyr Ser Leu Pro Gln Asp Asp Ile Asp Gly
                245                 250                 255     
Ile Gln Ala Ile Tyr Gly Leu Ser Ser Asn Pro Ile Gln Pro Thr Gly
            260                 265                 270         
Pro Ser Thr Pro Lys Pro Cys Asp Pro Ser Leu Thr Phe Asp Ala Ile
        275                 280                 285             
Thr Thr Leu Arg Gly Glu Ile Leu Phe Phe Lys Asp Arg Tyr Phe Trp
    290                 295                 300                 
Arg Arg His Pro Gln Leu Gln Arg Val Glu Met Asn Phe Ile Ser Leu
305                 310                 315                 320 
Phe Trp Pro Ser Leu Pro Thr Gly Ile Gln Ala Ala Tyr Glu Asp Phe
                325                 330                 335     
Asp Arg Asp Leu Ile Phe Leu Phe Lys Gly Asn Gln Tyr Trp Ala Leu
            340                 345                 350         
Ser Gly Tyr Asp Ile Leu Gln Gly Tyr Pro Lys Asp Ile Ser Asn Tyr
        355                 360                 365             
Gly Phe Pro Ser Ser Val Gln Ala Ile Asp Ala Ala Val Phe Tyr Arg
    370                 375                 380                 
Ser Lys Thr Tyr Phe Phe Val Asn Asp Gln Phe Trp Arg Tyr Asp Asn
385                 390                 395                 400 
Gln Arg Gln Phe Met Glu Pro Gly Tyr Pro Lys Ser Ile Ser Gly Ala
                405                 410                 415     
Phe Pro Gly Ile Glu Ser Lys Val Asp Ala Val Phe Gln Gln Glu His
            420                 425                 430         
Phe Phe His Val Phe Ser Gly Pro Arg Tyr Tyr Ala Phe Asp Leu Ile
        435                 440                 445             
Ala Gln Arg Val Thr Arg Val Ala Arg Gly Asn Lys Trp Leu Asn Cys
    450                 455                 460                 
Arg Tyr Gly
465         


<210> 102
<211> 367
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-8 mature

<400> 102
Leu Thr Pro Gly Asn Pro Lys Trp Glu Arg Thr Asn Leu Thr Tyr Arg
 1               5                  10                  15      
Ile Arg Asn Tyr Thr Pro Gln Leu Ser Glu Ala Glu Val Glu Arg Ala
            20                  25                  30          
Ile Lys Asp Ala Phe Glu Leu Trp Ser Val Ala Ser Pro Leu Ile Phe
        35                  40                  45              
Thr Arg Ile Ser Gln Gly Glu Ala Asp Ile Asn Ile Ala Phe Tyr Gln
    50                  55                  60                  
Arg Asp His Gly Asp Asn Ser Pro Phe Asp Gly Pro Asn Gly Ile Leu
65                  70                  75                  80  
Ala His Ala Phe Gln Pro Gly Gln Gly Ile Gly Gly Asp Ala His Phe
                85                  90                  95      
Asp Ala Glu Glu Thr Trp Thr Asn Thr Ser Ala Asn Tyr Asn Leu Phe
            100                 105                 110         
Leu Val Ala Ala His Glu Phe Gly His Ser Leu Gly Leu Ala His Ser
        115                 120                 125             
Ser Asp Pro Gly Ala Leu Met Tyr Pro Asn Tyr Ala Phe Arg Glu Thr
    130                 135                 140                 
Ser Asn Tyr Ser Leu Pro Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
145                 150                 155                 160 
Tyr Gly Leu Ser Ser Asn Pro Ile Gln Pro Thr Gly Pro Ser Thr Pro
                165                 170                 175     
Lys Pro Cys Asp Pro Ser Leu Thr Phe Asp Ala Ile Thr Thr Leu Arg
            180                 185                 190         
Gly Glu Ile Leu Phe Phe Lys Asp Arg Tyr Phe Trp Arg Arg His Pro
        195                 200                 205             
Gln Leu Gln Arg Val Glu Met Asn Phe Ile Ser Leu Phe Trp Pro Ser
    210                 215                 220                 
Leu Pro Thr Gly Ile Gln Ala Ala Tyr Glu Asp Phe Asp Arg Asp Leu
225                 230                 235                 240 
Ile Phe Leu Phe Lys Gly Asn Gln Tyr Trp Ala Leu Ser Gly Tyr Asp
                245                 250                 255     
Ile Leu Gln Gly Tyr Pro Lys Asp Ile Ser Asn Tyr Gly Phe Pro Ser
            260                 265                 270         
Ser Val Gln Ala Ile Asp Ala Ala Val Phe Tyr Arg Ser Lys Thr Tyr
        275                 280                 285             
Phe Phe Val Asn Asp Gln Phe Trp Arg Tyr Asp Asn Gln Arg Gln Phe
    290                 295                 300                 
Met Glu Pro Gly Tyr Pro Lys Ser Ile Ser Gly Ala Phe Pro Gly Ile
305                 310                 315                 320 
Glu Ser Lys Val Asp Ala Val Phe Gln Gln Glu His Phe Phe His Val
                325                 330                 335     
Phe Ser Gly Pro Arg Tyr Tyr Ala Phe Asp Leu Ile Ala Gln Arg Val
            340                 345                 350         
Thr Arg Val Ala Arg Gly Asn Lys Trp Leu Asn Cys Arg Tyr Gly
        355                 360                 365         


<210> 103
<211> 2722
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-13 precursor

<400> 103
caacagtccc caggcatcac cattcaagat gcatccaggg gtcctggctg ccttcctctt 60
cttgagctgg actcattgtc gggccctgcc ccttcccagt ggtggtgatg aagatgattt 120
gtctgaggaa gacctccagt ttgcagagcg ctacctgaga tcatactacc atcctacaaa 180
tctcgcggga atcctgaagg agaatgcagc aagctccatg actgagaggc tccgagaaat 240
gcagtctttc ttcggcttag aggtgactgg caaacttgac gataacacct tagatgtcat 300
gaaaaagcca agatgcgggg ttcctgatgt gggtgaatac aatgttttcc ctcgaactct 360
taaatggtcc aaaatgaatt taacctacag aattgtgaat tacacccctg atatgactca 420
ttctgaagtc gaaaaggcat tcaaaaaagc cttcaaagtt tggtccgatg taactcctct 480
gaattttacc agacttcacg atggcattgc tgacatcatg atctcttttg gaattaagga 540
gcatggcgac ttctacccat ttgatgggcc ctctggcctg ctggctcatg cttttcctcc 600
tgggccaaat tatggaggag atgcccattt tgatgatgat gaaacctgga caagtagttc 660
caaaggctac aacttgtttc ttgttgctgc gcatgagttc ggccactcct taggtcttga 720
ccactccaag gaccctggag cactcatgtt tcctatctac acctacaccg gcaaaagcca 780
ctttatgctt cctgatgacg atgtacaagg gatccagtct ctctatggtc caggagatga 840
agaccccaac cctaaacatc caaaaacgcc agacaaatgt gacccttcct tatcccttga 900
tgccattacc agtctccgag gagaaacaat gatctttaaa gacagattct tctggcgcct 960
gcatcctcag caggttgatg cggagctgtt tttaacgaaa tcattttggc cagaacttcc 1020
caaccgtatt gatgctgcat atgagcaccc ttctcatgac ctcatcttca tcttcagagg 1080
tagaaaattt tgggctctta atggttatga cattctggaa ggttatccca aaaaaatatc 1140
tgaactgggt cttccaaaag aagttaagaa gataagtgca gctgttcact ttgaggatac 1200
aggcaagact ctcctgttct caggaaacca ggtctggaga tatgatgata ctaaccatat 1260
tatggataaa gactatccga gactaataga agaagacttc ccaggaattg gtgataaagt 1320
agatgctgtc tatgagaaaa atggttatat ctattttttc aacggaccca tacagtttga 1380
atacagcatc tggagtaacc gtattgttcg cgtcatgcca gcaaattcca ttttgtggtg 1440
ttaagtgtct ttttaaaaat tgttatttaa atcctgaaga gcatttgggg taatacttcc 1500
agaagtgcgg ggtaggggaa gaagagctat caggagaaag cttggttctg tgaacaagct 1560
tcagtaagtt atctttgaat atgtagtatc tatatgacta tgcgtggctg gaaccacatt 1620
gaagaatgtt agagtaatga aatggaggat ctctaaagag catctgattc ttgttgctgt 1680
acaaaagcaa tggttgatga tacttcccac accacaaatg ggacacatgg tctgtcaatg 1740
agagcataat ttaaaaatat atttataagg aaattttaca agggcataaa gtaaatacat 1800
gcatataatg aataaatcat tcttactaaa aagtataaaa tagtatgaaa atggaaattt 1860
gggagagcca tacataaaag aaataaacca aaggaaaatg tctgtaataa tagactgtaa 1920
cttccaaata aataattttc attttgcact gaggatattc agatgtatgt gcccttcttc 1980
acacagacac taacgaaata tcaaagtcat taaagacagg agacaaaaga gcagtggtaa 2040
gaatagtaga tgtggccttt gaattctgtt taattttcac ttttggcaat gactcaaagt 2100
ctgctctcat ataagacaaa tattcctttg catattataa aggataaaga aggatgatgt 2160
ctttttatta aaatatttca ggttcttcag aagtcacaca ttacaaagtt aaaattgtta 2220
tcaaaatagt ctaaggccat ggcatccctt tttcataaat tatttgatta tttaagacta 2280
aaagttgcat tttaacccta ttttacctag ctaattattt aattgtccgg tttgtcttgg 2340
atatataggc tattttctaa agacttgtat agcatgaaat aaaatatatc ttataaagtg 2400
gaagtatgta tattaaaaaa gagacatcca aatttttttt taaagcagtc tactagattg 2460
tgatcccttg agatatggaa ggatgccttt ttttctctgc atttaaaaaa atcccccagc 2520
acttcccaca gtgcctattg atacttgggg agggtgcttg gcacttattg aatatatgat 2580
cggccatcaa gggaagaact attgtgctca gagacactgt tgataaaaac tcaggcaaag 2640
aaaatgaaat gcatatttgc aaagtgtatt aggaagtgtt tatgttgttt ataataaaaa 2700
tatattttca acagaaaaaa aa                                          2722

<210> 104
<211> 471
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-13 precursor

<400> 104
Met His Pro Gly Val Leu Ala Ala Phe Leu Phe Leu Ser Trp Thr His
 1               5                  10                  15      
Cys Arg Ala Leu Pro Leu Pro Ser Gly Gly Asp Glu Asp Asp Leu Ser
            20                  25                  30          
Glu Glu Asp Leu Gln Phe Ala Glu Arg Tyr Leu Arg Ser Tyr Tyr His
        35                  40                  45              
Pro Thr Asn Leu Ala Gly Ile Leu Lys Glu Asn Ala Ala Ser Ser Met
    50                  55                  60                  
Thr Glu Arg Leu Arg Glu Met Gln Ser Phe Phe Gly Leu Glu Val Thr
65                  70                  75                  80  
Gly Lys Leu Asp Asp Asn Thr Leu Asp Val Met Lys Lys Pro Arg Cys
                85                  90                  95      
Gly Val Pro Asp Val Gly Glu Tyr Asn Val Phe Pro Arg Thr Leu Lys
            100                 105                 110         
Trp Ser Lys Met Asn Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp
        115                 120                 125             
Met Thr His Ser Glu Val Glu Lys Ala Phe Lys Lys Ala Phe Lys Val
    130                 135                 140                 
Trp Ser Asp Val Thr Pro Leu Asn Phe Thr Arg Leu His Asp Gly Ile
145                 150                 155                 160 
Ala Asp Ile Met Ile Ser Phe Gly Ile Lys Glu His Gly Asp Phe Tyr
                165                 170                 175     
Pro Phe Asp Gly Pro Ser Gly Leu Leu Ala His Ala Phe Pro Pro Gly
            180                 185                 190         
Pro Asn Tyr Gly Gly Asp Ala His Phe Asp Asp Asp Glu Thr Trp Thr
        195                 200                 205             
Ser Ser Ser Lys Gly Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe
    210                 215                 220                 
Gly His Ser Leu Gly Leu Asp His Ser Lys Asp Pro Gly Ala Leu Met
225                 230                 235                 240 
Phe Pro Ile Tyr Thr Tyr Thr Gly Lys Ser His Phe Met Leu Pro Asp
                245                 250                 255     
Asp Asp Val Gln Gly Ile Gln Ser Leu Tyr Gly Pro Gly Asp Glu Asp
            260                 265                 270         
Pro Asn Pro Lys His Pro Lys Thr Pro Asp Lys Cys Asp Pro Ser Leu
        275                 280                 285             
Ser Leu Asp Ala Ile Thr Ser Leu Arg Gly Glu Thr Met Ile Phe Lys
    290                 295                 300                 
Asp Arg Phe Phe Trp Arg Leu His Pro Gln Gln Val Asp Ala Glu Leu
305                 310                 315                 320 
Phe Leu Thr Lys Ser Phe Trp Pro Glu Leu Pro Asn Arg Ile Asp Ala
                325                 330                 335     
Ala Tyr Glu His Pro Ser His Asp Leu Ile Phe Ile Phe Arg Gly Arg
            340                 345                 350         
Lys Phe Trp Ala Leu Asn Gly Tyr Asp Ile Leu Glu Gly Tyr Pro Lys
        355                 360                 365             
Lys Ile Ser Glu Leu Gly Leu Pro Lys Glu Val Lys Lys Ile Ser Ala
    370                 375                 380                 
Ala Val His Phe Glu Asp Thr Gly Lys Thr Leu Leu Phe Ser Gly Asn
385                 390                 395                 400 
Gln Val Trp Arg Tyr Asp Asp Thr Asn His Ile Met Asp Lys Asp Tyr
                405                 410                 415     
Pro Arg Leu Ile Glu Glu Asp Phe Pro Gly Ile Gly Asp Lys Val Asp
            420                 425                 430         
Ala Val Tyr Glu Lys Asn Gly Tyr Ile Tyr Phe Phe Asn Gly Pro Ile
        435                 440                 445             
Gln Phe Glu Tyr Ser Ile Trp Ser Asn Arg Ile Val Arg Val Met Pro
    450                 455                 460                 
Ala Asn Ser Ile Leu Trp Cys
465                 470     


<210> 105
<211> 368
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-13 mature

<400> 105
Tyr Asn Val Phe Pro Arg Thr Leu Lys Trp Ser Lys Met Asn Leu Thr
 1               5                  10                  15      
Tyr Arg Ile Val Asn Tyr Thr Pro Asp Met Thr His Ser Glu Val Glu
            20                  25                  30          
Lys Ala Phe Lys Lys Ala Phe Lys Val Trp Ser Asp Val Thr Pro Leu
        35                  40                  45              
Asn Phe Thr Arg Leu His Asp Gly Ile Ala Asp Ile Met Ile Ser Phe
    50                  55                  60                  
Gly Ile Lys Glu His Gly Asp Phe Tyr Pro Phe Asp Gly Pro Ser Gly
65                  70                  75                  80  
Leu Leu Ala His Ala Phe Pro Pro Gly Pro Asn Tyr Gly Gly Asp Ala
                85                  90                  95      
His Phe Asp Asp Asp Glu Thr Trp Thr Ser Ser Ser Lys Gly Tyr Asn
            100                 105                 110         
Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ser Leu Gly Leu Asp
        115                 120                 125             
His Ser Lys Asp Pro Gly Ala Leu Met Phe Pro Ile Tyr Thr Tyr Thr
    130                 135                 140                 
Gly Lys Ser His Phe Met Leu Pro Asp Asp Asp Val Gln Gly Ile Gln
145                 150                 155                 160 
Ser Leu Tyr Gly Pro Gly Asp Glu Asp Pro Asn Pro Lys His Pro Lys
                165                 170                 175     
Thr Pro Asp Lys Cys Asp Pro Ser Leu Ser Leu Asp Ala Ile Thr Ser
            180                 185                 190         
Leu Arg Gly Glu Thr Met Ile Phe Lys Asp Arg Phe Phe Trp Arg Leu
        195                 200                 205             
His Pro Gln Gln Val Asp Ala Glu Leu Phe Leu Thr Lys Ser Phe Trp
    210                 215                 220                 
Pro Glu Leu Pro Asn Arg Ile Asp Ala Ala Tyr Glu His Pro Ser His
225                 230                 235                 240 
Asp Leu Ile Phe Ile Phe Arg Gly Arg Lys Phe Trp Ala Leu Asn Gly
                245                 250                 255     
Tyr Asp Ile Leu Glu Gly Tyr Pro Lys Lys Ile Ser Glu Leu Gly Leu
            260                 265                 270         
Pro Lys Glu Val Lys Lys Ile Ser Ala Ala Val His Phe Glu Asp Thr
        275                 280                 285             
Gly Lys Thr Leu Leu Phe Ser Gly Asn Gln Val Trp Arg Tyr Asp Asp
    290                 295                 300                 
Thr Asn His Ile Met Asp Lys Asp Tyr Pro Arg Leu Ile Glu Glu Asp
305                 310                 315                 320 
Phe Pro Gly Ile Gly Asp Lys Val Asp Ala Val Tyr Glu Lys Asn Gly
                325                 330                 335     
Tyr Ile Tyr Phe Phe Asn Gly Pro Ile Gln Phe Glu Tyr Ser Ile Trp
            340                 345                 350         
Ser Asn Arg Ile Val Arg Val Met Pro Ala Asn Ser Ile Leu Trp Cys
        355                 360                 365             


<210> 106
<211> 1609
<212> DNA
<213> Xenopus laevis

<220> 
<223> MMP-18

<400> 106
accttcaaat cctagaaagc cttagaagaa tgaacagcct cctgctaaag ctgctactat 60
gtgtagccat tactgctgcc ttcccagcag ataaacaaga tgagccccca gcaacaaagg 120
aagaaatggc agagaattac ttgaagagat tttacagtct tggaactgat gggggaccag 180
ttggaagaaa gaaacacatc caacctttca ctgaaaagct cgagcagatg cagaagtttt 240
ttggcttaaa ggtgacagga acattggacc ccaagactgt agaagtaatg gagaaaccca 300

gatgtggagt ctatgatgtt ggccagtaca gcacagtcgc aaaaagttct gcatggcaga 360
agaaggatct gacctacaga attctaaact tcactcctga cctgcctcag gctgatgtgg 420
agactgccat acaaagagct ttcaaagtct ggagtgacgt gacacctttg acctttacca 480
gaatctacaa tgaagtatca gatatagaaa tctcctttac agctggagat cacaaagaca 540
attctccttt tgatggatct ggtggcattt tggcccatgc ctttcagccc ggcaatggca 600
ttggtggaga tgcccatttt gatgaagatg aaacctggac aaagaccagt gaaatataca 660
atctgtttct tgttgctgct catgaatttg gacactcgct ggggctttct cattccactg 720
atcagggtgc tttgatgtat ccaacatact caaataccga ccccaagaca tttcagcttc 780
ctcaagatga tatcaatgct atacagtatc tatatggaaa atcctccaat ccagtccaac 840
caaccggacc atccactcct tccagatgtg atccaaatgt tgttttcaat gctgtcacca 900
ccatgagagg agaactgatt ttctttgtga agaggttttt atggaggaag catccccaag 960
catccgaggc tgaactcatg tttgttcaag cattctggcc atcgctgccc actaatattg 1020
atgcggcgta tgaaaatcct ataacggagc agatccttgt gtttaaagga tcaaaatata 1080
cagctctgga cggcttcgat gtagtacaag gttaccccag gaacatctac agcctgggat 1140
ttccaaagac cgtgaaaaga attgatgcgg ctgttcatat tgaacaacta gggaaaacat 1200
atttctttgc agctaagaaa tactggagtt atgatgaaga taaaaaacaa atggacaaag 1260
gctttccaaa gcaaataagc aacgatttcc cgggaattcc tgataaaatt gatgcagctt 1320
tttattacag aggccgcctg tatttcttca ttggaaggag ccagtttgaa tacaatatca 1380
actctaaaag aatcgtacag gtcttaagaa gcaacagctg gttgggctgt taataagacg 1440
gaccccaagc tctgtaacaa gggcaacgat gaatgtgatg gcagctcatt tctgcacctg 1500
ccgtgtgacc aatattattt aaaatcattt cctttgaatg tttgacttta tttaatcttt 1560
atgaattaat attttgtact catgttgttt taataaaaac gttttgttt             1609

<210> 107
<211> 467
<212> PRT
<213> Xenopus laevis

<220> 
<223> MMP-18

<400> 107
Met Asn Ser Leu Leu Leu Lys Leu Leu Leu Cys Val Ala Ile Thr Ala
 1               5                  10                  15      
Ala Phe Pro Ala Asp Lys Gln Asp Glu Pro Pro Ala Thr Lys Glu Glu
            20                  25                  30          
Met Ala Glu Asn Tyr Leu Lys Arg Phe Tyr Ser Leu Gly Thr Asp Gly
        35                  40                  45              
Gly Pro Val Gly Arg Lys Lys His Ile Gln Pro Phe Thr Glu Lys Leu
    50                  55                  60                  
Glu Gln Met Gln Lys Phe Phe Gly Leu Lys Val Thr Gly Thr Leu Asp
65                  70                  75                  80  
Pro Lys Thr Val Glu Val Met Glu Lys Pro Arg Cys Gly Val Tyr Asp
                85                  90                  95      
Val Gly Gln Tyr Ser Thr Val Ala Lys Ser Ser Ala Trp Gln Lys Lys
            100                 105                 110         
Asp Leu Thr Tyr Arg Ile Leu Asn Phe Thr Pro Asp Leu Pro Gln Ala
        115                 120                 125             
Asp Val Glu Thr Ala Ile Gln Arg Ala Phe Lys Val Trp Ser Asp Val
    130                 135                 140                 
Thr Pro Leu Thr Phe Thr Arg Ile Tyr Asn Glu Val Ser Asp Ile Glu
145                 150                 155                 160 
Ile Ser Phe Thr Ala Gly Asp His Lys Asp Asn Ser Pro Phe Asp Gly
                165                 170                 175     
Ser Gly Gly Ile Leu Ala His Ala Phe Gln Pro Gly Asn Gly Ile Gly
            180                 185                 190         
Gly Asp Ala His Phe Asp Glu Asp Glu Thr Trp Thr Lys Thr Ser Glu
        195                 200                 205             
Ile Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ser Leu
    210                 215                 220                 
Gly Leu Ser His Ser Thr Asp Gln Gly Ala Leu Met Tyr Pro Thr Tyr
225                 230                 235                 240 
Ser Asn Thr Asp Pro Lys Thr Phe Gln Leu Pro Gln Asp Asp Ile Asn
                245                 250                 255     
Ala Ile Gln Tyr Leu Tyr Gly Lys Ser Ser Asn Pro Val Gln Pro Thr
            260                 265                 270         
Gly Pro Ser Thr Pro Ser Arg Cys Asp Pro Asn Val Val Phe Asn Ala
        275                 280                 285             
Val Thr Thr Met Arg Gly Glu Leu Ile Phe Phe Val Lys Arg Phe Leu
    290                 295                 300                 
Trp Arg Lys His Pro Gln Ala Ser Glu Ala Glu Leu Met Phe Val Gln
305                 310                 315                 320 
Ala Phe Trp Pro Ser Leu Pro Thr Asn Ile Asp Ala Ala Tyr Glu Asn

                325                 330                 335     
Pro Ile Thr Glu Gln Ile Leu Val Phe Lys Gly Ser Lys Tyr Thr Ala
            340                 345                 350         
Leu Asp Gly Phe Asp Val Val Gln Gly Tyr Pro Arg Asn Ile Tyr Ser
        355                 360                 365             
Leu Gly Phe Pro Lys Thr Val Lys Arg Ile Asp Ala Ala Val His Ile
    370                 375                 380                 
Glu Gln Leu Gly Lys Thr Tyr Phe Phe Ala Ala Lys Lys Tyr Trp Ser
385                 390                 395                 400 
Tyr Asp Glu Asp Lys Lys Gln Met Asp Lys Gly Phe Pro Lys Gln Ile
                405                 410                 415     
Ser Asn Asp Phe Pro Gly Ile Pro Asp Lys Ile Asp Ala Ala Phe Tyr
            420                 425                 430         
Tyr Arg Gly Arg Leu Tyr Phe Phe Ile Gly Arg Ser Gln Phe Glu Tyr
        435                 440                 445             
Asn Ile Asn Ser Lys Arg Ile Val Gln Val Leu Arg Ser Asn Ser Trp
    450                 455                 460                 
Leu Gly Cys
465         


<210> 108
<211> 368
<212> PRT
<213> Xenopus laevis

<220> 
<223> MMP-18 mature

<400> 108
Tyr Ser Thr Val Ala Lys Ser Ser Ala Trp Gln Lys Lys Asp Leu Thr
 1               5                  10                  15      
Tyr Arg Ile Leu Asn Phe Thr Pro Asp Leu Pro Gln Ala Asp Val Glu
            20                  25                  30          
Thr Ala Ile Gln Arg Ala Phe Lys Val Trp Ser Asp Val Thr Pro Leu
        35                  40                  45              
Thr Phe Thr Arg Ile Tyr Asn Glu Val Ser Asp Ile Glu Ile Ser Phe
    50                  55                  60                  
Thr Ala Gly Asp His Lys Asp Asn Ser Pro Phe Asp Gly Ser Gly Gly
65                  70                  75                  80  
Ile Leu Ala His Ala Phe Gln Pro Gly Asn Gly Ile Gly Gly Asp Ala
                85                  90                  95      
His Phe Asp Glu Asp Glu Thr Trp Thr Lys Thr Ser Glu Ile Tyr Asn
            100                 105                 110         
Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ser Leu Gly Leu Ser
        115                 120                 125             
His Ser Thr Asp Gln Gly Ala Leu Met Tyr Pro Thr Tyr Ser Asn Thr
    130                 135                 140                 
Asp Pro Lys Thr Phe Gln Leu Pro Gln Asp Asp Ile Asn Ala Ile Gln
145                 150                 155                 160 
Tyr Leu Tyr Gly Lys Ser Ser Asn Pro Val Gln Pro Thr Gly Pro Ser
                165                 170                 175     
Thr Pro Ser Arg Cys Asp Pro Asn Val Val Phe Asn Ala Val Thr Thr
            180                 185                 190         

Met Arg Gly Glu Leu Ile Phe Phe Val Lys Arg Phe Leu Trp Arg Lys
        195                 200                 205             
His Pro Gln Ala Ser Glu Ala Glu Leu Met Phe Val Gln Ala Phe Trp
    210                 215                 220                 
Pro Ser Leu Pro Thr Asn Ile Asp Ala Ala Tyr Glu Asn Pro Ile Thr
225                 230                 235                 240 
Glu Gln Ile Leu Val Phe Lys Gly Ser Lys Tyr Thr Ala Leu Asp Gly
                245                 250                 255     
Phe Asp Val Val Gln Gly Tyr Pro Arg Asn Ile Tyr Ser Leu Gly Phe
            260                 265                 270         
Pro Lys Thr Val Lys Arg Ile Asp Ala Ala Val His Ile Glu Gln Leu
        275                 280                 285             
Gly Lys Thr Tyr Phe Phe Ala Ala Lys Lys Tyr Trp Ser Tyr Asp Glu
    290                 295                 300                 
Asp Lys Lys Gln Met Asp Lys Gly Phe Pro Lys Gln Ile Ser Asn Asp
305                 310                 315                 320 
Phe Pro Gly Ile Pro Asp Lys Ile Asp Ala Ala Phe Tyr Tyr Arg Gly
                325                 330                 335     
Arg Leu Tyr Phe Phe Ile Gly Arg Ser Gln Phe Glu Tyr Asn Ile Asn
            340                 345                 350         
Ser Lys Arg Ile Val Gln Val Leu Arg Ser Asn Ser Trp Leu Gly Cys
        355                 360                 365             


<210> 109
<211> 3546
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-2

<400> 109
gcggctgccc tcccttgttt ccgctgcatc cagacttcct caggcggtgg ctggaggctg 60
cgcatctggg gctttaaaca tacaaaggga ttgccaggac ctgcggcggc ggcggcggcg 120
gcgggggctg gggcgcgggg gccggaccat gagccgctga gccgggcaaa ccccaggcca 180
ccgagccagc ggaccctcgg agcgcagccc tgcgccgcgg agcaggctcc aaccaggcgg 240
cgaggcggcc acacgcaccg agccagcgac ccccgggcga cgcgcggggc cagggagcgc 300
tacgatggag gcgctaatgg cccggggcgc gctcacgggt cccctgaggg cgctctgtct 360
cctgggctgc ctgctgagcc acgccgccgc cgcgccgtcg cccatcatca agttccccgg 420
cgatgtcgcc cccaaaacgg acaaagagtt ggcagtgcaa tacctgaaca ccttctatgg 480
ctgccccaag gagagctgca acctgtttgt gctgaaggac acactaaaga agatgcagaa 540
gttctttgga ctgccccaga caggtgatct tgaccagaat accatcgaga ccatgcggaa 600
gccacgctgc ggcaacccag atgtggccaa ctacaacttc ttccctcgca agcccaagtg 660
ggacaagaac cagatcacat acaggatcat tggctacaca cctgatctgg acccagagac 720
agtggatgat gcctttgctc gtgccttcca agtctggagc gatgtgaccc cactgcggtt 780
ttctcgaatc catgatggag aggcagacat catgatcaac tttggccgct gggagcatgg 840
cgatggatac ccctttgacg gtaaggacgg actcctggct catgccttcg ccccaggcac 900
tggtgttggg ggagactccc attttgatga cgatgagcta tggaccttgg gagaaggcca 960
agtggtccgt gtgaagtatg ggaacgccga tggggagtac tgcaagttcc ccttcttgtt 1020
caatggcaag gagtacaaca gctgcactga taccggccgc agcgatggct tcctctggtg 1080
ctccaccacc tacaactttg agaaggatgg caagtacggc ttctgtcccc atgaagccct 1140
gttcaccatg ggcggcaacg ctgaaggaca gccctgcaag tttccattcc gcttccaggg 1200
cacatcctat gacagctgca ccactgaggg ccgcacggat ggctaccgct ggtgcggcac 1260
cactgaggac tacgaccgcg acaagaagta tggcttctgc cctgagaccg ccatgtccac 1320
tgttggtggg aactcagaag gtgccccctg tgtcttcccc ttcactttcc tgggcaacaa 1380
atatgagagc tgcaccagcg ccggccgcag tgacggaaag atgtggtgtg cgaccacagc 1440
caactacgat gatgaccgca agtggggctt ctgccctgac caagggtaca gcctgttcct 1500
cgtggcagcc cacgagtttg gccacgccat ggggctggag cactcccaag accctggggc 1560
cctgatggca cccatttaca cctacaccaa gaacttccgt ctgtcccagg atgacatcaa 1620
gggcattcag gagctctatg gggcctctcc tgacattgac cttggcaccg gccccacccc 1680
cacgctgggc cctgtcactc ctgagatctg caaacaggac attgtatttg atggcatcgc 1740
tcagatccgt ggtgagatct tcttcttcaa ggaccggttc atttggcgga ctgtgacgcc 1800
acgtgacaag cccatggggc ccctgctggt ggccacattc tggcctgagc tcccggaaaa 1860
gattgatgcg gtatacgagg ccccacagga ggagaaggct gtgttctttg cagggaatga 1920
atactggatc tactcagcca gcaccctgga gcgagggtac cccaagccac tgaccagcct 1980
gggactgccc cctgatgtcc agcgagtgga tgccgccttt aactggagca aaaacaagaa 2040
gacatacatc tttgctggag acaaattctg gagatacaat gaggtgaaga agaaaatgga 2100
tcctggcttc cccaagctca tcgcagatgc ctggaatgcc atccccgata acctggatgc 2160
cgtcgtggac ctgcagggcg gcggtcacag ctacttcttc aagggtgcct attacctgaa 2220
gctggagaac caaagtctga agagcgtgaa gtttggaagc atcaaatccg actggctagg 2280
ctgctgagct ggccctggct cccacaggcc cttcctctcc actgccttcg atacaccggg 2340
cctggagaac tagagaagga cccggagggg cctggcagcc gtgccttcag ctctacagct 2400
aatcagcatt ctcactccta cctggtaatt taagattcca gagagtggct cctcccggtg 2460
cccaagaata gatgctgact gtactcctcc caggcgcccc ttccccctcc aatcccacca 2520
accctcagag ccacccctaa agagatactt tgatattttc aacgcagccc tgctttgggc 2580
tgccctggtg ctgccacact tcaggctctt ctcctttcac aaccttctgt ggctcacaga 2640
acccttggag ccaatggaga ctgtctcaag agggcactgg tggcccgaca gcctggcaca 2700
gggcagtggg acagggcatg gccaggtggc cactccagac ccctggcttt tcactgctgg 2760
ctgccttaga acctttctta cattagcagt ttgctttgta tgcactttgt ttttttcttt 2820
gggtcttgtt ttttttttcc acttagaaat tgcatttcct gacagaagga ctcaggttgt 2880
ctgaagtcac tgcacagtgc atctcagccc acatagtgat ggttcccctg ttcactctac 2940
ttagcatgtc cctaccgagt ctcttctcca ctggatggag gaaaaccaag ccgtggcttc 3000
ccgctcagcc ctccctgccc ctcccttcaa ccattcccca tgggaaatgt caacaagtat 3060
gaataaagac acctactgag tggccgtgtt tgccatctgt tttagcagag cctagacaag 3120
ggccacagac ccagccagaa gcggaaactt aaaaagtccg aatctctgct ccctgcaggg 3180
cacaggtgat ggtgtctgct ggaaaggtca gagcttccaa agtaaacagc aagagaacct 3240
cagggagagt aagctctagt ccctctgtcc tgtagaaaga gccctgaaga atcagcaatt 3300
ttgttgcttt attgtggcat ctgttcgagg tttgcttcct ctttaagtct gtttcttcat 3360
tagcaatcat atcagtttta atgctactac taacaatgaa cagtaacaat aatatccccc 3420
tcaattaata gagtgctttc tatgtgcaag gcacttttca cgtgtcacct attttaacct 3480
ttccaaccac ataaataaaa aaggccatta ttagttgaat cttattgatg aagagaaaaa 3540
aaaaaa                                                            3546

<210> 110
<211> 660
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-2 precursor

<400> 110
Met Glu Ala Leu Met Ala Arg Gly Ala Leu Thr Gly Pro Leu Arg Ala
 1               5                  10                  15      
Leu Cys Leu Leu Gly Cys Leu Leu Ser His Ala Ala Ala Ala Pro Ser
            20                  25                  30          
Pro Ile Ile Lys Phe Pro Gly Asp Val Ala Pro Lys Thr Asp Lys Glu
        35                  40                  45              
Leu Ala Val Gln Tyr Leu Asn Thr Phe Tyr Gly Cys Pro Lys Glu Ser
    50                  55                  60                  
Cys Asn Leu Phe Val Leu Lys Asp Thr Leu Lys Lys Met Gln Lys Phe
65                  70                  75                  80  
Phe Gly Leu Pro Gln Thr Gly Asp Leu Asp Gln Asn Thr Ile Glu Thr
                85                  90                  95      
Met Arg Lys Pro Arg Cys Gly Asn Pro Asp Val Ala Asn Tyr Asn Phe
            100                 105                 110         
Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile Thr Tyr Arg Ile
        115                 120                 125             
Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val Asp Asp Ala Phe
    130                 135                 140                 
Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro Leu Arg Phe Ser
145                 150                 155                 160 
Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn Phe Gly Arg Trp
                165                 170                 175     
Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala
            180                 185                 190         
His Ala Phe Ala Pro Gly Thr Gly Val Gly Gly Asp Ser His Phe Asp
        195                 200                 205             
Asp Asp Glu Leu Trp Thr Leu Gly Glu Gly Gln Val Val Arg Val Lys
    210                 215                 220                 
Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu Phe Asn
225                 230                 235                 240 
Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser Asp Gly Phe
                245                 250                 255     
Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys Tyr Gly
            260                 265                 270         
Phe Cys Pro His Glu Ala Leu Phe Thr Met Gly Gly Asn Ala Glu Gly
        275                 280                 285             
Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser Tyr Asp Ser
    290                 295                 300                 
Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr
305                 310                 315                 320 
Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro Glu Thr Ala
                325                 330                 335     
Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro Cys Val Phe Pro
            340                 345                 350         
Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser Ala Gly Arg
        355                 360                 365             
Ser Asp Gly Lys Met Trp Cys Ala Thr Thr Ala Asn Tyr Asp Asp Asp
    370                 375                 380                 
Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val
385                 390                 395                 400 
Ala Ala His Glu Phe Gly His Ala Met Gly Leu Glu His Ser Gln Asp
                405                 410                 415     
Pro Gly Ala Leu Met Ala Pro Ile Tyr Thr Tyr Thr Lys Asn Phe Arg
            420                 425                 430         
Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Glu Leu Tyr Gly Ala Ser
        435                 440                 445             
Pro Asp Ile Asp Leu Gly Thr Gly Pro Thr Pro Thr Leu Gly Pro Val
    450                 455                 460                 
Thr Pro Glu Ile Cys Lys Gln Asp Ile Val Phe Asp Gly Ile Ala Gln
465                 470                 475                 480 
Ile Arg Gly Glu Ile Phe Phe Phe Lys Asp Arg Phe Ile Trp Arg Thr
                485                 490                 495     
Val Thr Pro Arg Asp Lys Pro Met Gly Pro Leu Leu Val Ala Thr Phe
            500                 505                 510         
Trp Pro Glu Leu Pro Glu Lys Ile Asp Ala Val Tyr Glu Ala Pro Gln
        515                 520                 525             
Glu Glu Lys Ala Val Phe Phe Ala Gly Asn Glu Tyr Trp Ile Tyr Ser
    530                 535                 540                 
Ala Ser Thr Leu Glu Arg Gly Tyr Pro Lys Pro Leu Thr Ser Leu Gly
545                 550                 555                 560 
Leu Pro Pro Asp Val Gln Arg Val Asp Ala Ala Phe Asn Trp Ser Lys
                565                 570                 575     
Asn Lys Lys Thr Tyr Ile Phe Ala Gly Asp Lys Phe Trp Arg Tyr Asn
            580                 585                 590         
Glu Val Lys Lys Lys Met Asp Pro Gly Phe Pro Lys Leu Ile Ala Asp
        595                 600                 605             
Ala Trp Asn Ala Ile Pro Asp Asn Leu Asp Ala Val Val Asp Leu Gln
    610                 615                 620                 
Gly Gly Gly His Ser Tyr Phe Phe Lys Gly Ala Tyr Tyr Leu Lys Leu
625                 630                 635                 640 
Glu Asn Gln Ser Leu Lys Ser Val Lys Phe Gly Ser Ile Lys Ser Asp
                645                 650                 655     
Trp Leu Gly Cys
            660 


<210> 111
<211> 551
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-2 mature

<400> 111
Tyr Asn Phe Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile Thr
 1               5                  10                  15      
Tyr Arg Ile Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val Asp
            20                  25                  30          
Asp Ala Phe Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro Leu
        35                  40                  45              
Arg Phe Ser Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn Phe
    50                  55                  60                  
Gly Arg Trp Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly
65                  70                  75                  80  
Leu Leu Ala His Ala Phe Ala Pro Gly Thr Gly Val Gly Gly Asp Ser
                85                  90                  95      
His Phe Asp Asp Asp Glu Leu Trp Thr Leu Gly Glu Gly Gln Val Val
            100                 105                 110         
Arg Val Lys Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe
        115                 120                 125             
Leu Phe Asn Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser
    130                 135                 140                 
Asp Gly Phe Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly
145                 150                 155                 160 
Lys Tyr Gly Phe Cys Pro His Glu Ala Leu Phe Thr Met Gly Gly Asn
                165                 170                 175     
Ala Glu Gly Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser
            180                 185                 190         
Tyr Asp Ser Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys
        195                 200                 205             
Gly Thr Thr Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro
    210                 215                 220                 
Glu Thr Ala Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro Cys
225                 230                 235                 240 
Val Phe Pro Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser
                245                 250                 255     
Ala Gly Arg Ser Asp Gly Lys Met Trp Cys Ala Thr Thr Ala Asn Tyr
            260                 265                 270         
Asp Asp Asp Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu
        275                 280                 285             
Phe Leu Val Ala Ala His Glu Phe Gly His Ala Met Gly Leu Glu His
    290                 295                 300                 
Ser Gln Asp Pro Gly Ala Leu Met Ala Pro Ile Tyr Thr Tyr Thr Lys
305                 310                 315                 320 
Asn Phe Arg Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Glu Leu Tyr
                325                 330                 335     
Gly Ala Ser Pro Asp Ile Asp Leu Gly Thr Gly Pro Thr Pro Thr Leu
            340                 345                 350         
Gly Pro Val Thr Pro Glu Ile Cys Lys Gln Asp Ile Val Phe Asp Gly
        355                 360                 365             
Ile Ala Gln Ile Arg Gly Glu Ile Phe Phe Phe Lys Asp Arg Phe Ile
    370                 375                 380                 
Trp Arg Thr Val Thr Pro Arg Asp Lys Pro Met Gly Pro Leu Leu Val
385                 390                 395                 400 
Ala Thr Phe Trp Pro Glu Leu Pro Glu Lys Ile Asp Ala Val Tyr Glu
                405                 410                 415     
Ala Pro Gln Glu Glu Lys Ala Val Phe Phe Ala Gly Asn Glu Tyr Trp
            420                 425                 430         
Ile Tyr Ser Ala Ser Thr Leu Glu Arg Gly Tyr Pro Lys Pro Leu Thr
        435                 440                 445             
Ser Leu Gly Leu Pro Pro Asp Val Gln Arg Val Asp Ala Ala Phe Asn
    450                 455                 460                 
Trp Ser Lys Asn Lys Lys Thr Tyr Ile Phe Ala Gly Asp Lys Phe Trp
465                 470                 475                 480 
Arg Tyr Asn Glu Val Lys Lys Lys Met Asp Pro Gly Phe Pro Lys Leu
                485                 490                 495     
Ile Ala Asp Ala Trp Asn Ala Ile Pro Asp Asn Leu Asp Ala Val Val
            500                 505                 510         
Asp Leu Gln Gly Gly Gly His Ser Tyr Phe Phe Lys Gly Ala Tyr Tyr
        515                 520                 525             
Leu Lys Leu Glu Asn Gln Ser Leu Lys Ser Val Lys Phe Gly Ser Ile
    530                 535                 540                 
Lys Ser Asp Trp Leu Gly Cys
545                 550     


<210> 112
<211> 2387
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-9

<400> 112
agacacctct gccctcacca tgagcctctg gcagcccctg gtcctggtgc tcctggtgct 60
gggctgctgc tttgctgccc ccagacagcg ccagtccacc cttgtgctct tccctggaga 120
cctgagaacc aatctcaccg acaggcagct ggcagaggaa tacctgtacc gctatggtta 180
cactcgggtg gcagagatgc gtggagagtc gaaatctctg gggcctgcgc tgctgcttct 240
ccagaagcaa ctgtccctgc ccgagaccgg tgagctggat agcgccacgc tgaaggccat 300
gcgaacccca cggtgcgggg tcccagacct gggcagattc caaacctttg agggcgacct 360
caagtggcac caccacaaca tcacctattg gatccaaaac tactcggaag acttgccgcg 420
ggcggtgatt gacgacgcct ttgcccgcgc cttcgcactg tggagcgcgg tgacgccgct 480
caccttcact cgcgtgtaca gccgggacgc agacatcgtc atccagtttg gtgtcgcgga 540
gcacggagac gggtatccct tcgacgggaa ggacgggctc ctggcacacg cctttcctcc 600
tggccccggc attcagggag acgcccattt cgacgatgac gagttgtggt ccctgggcaa 660
gggcgtcgtg gttccaactc ggtttggaaa cgcagatggc gcggcctgcc acttcccctt 720
catcttcgag ggccgctcct actctgcctg caccaccgac ggtcgctccg acggcttgcc 780
ctggtgcagt accacggcca actacgacac cgacgaccgg tttggcttct gccccagcga 840
gagactctac acccaggacg gcaatgctga tgggaaaccc tgccagtttc cattcatctt 900
ccaaggccaa tcctactccg cctgcaccac ggacggtcgc tccgacggct accgctggtg 960
cgccaccacc gccaactacg accgggacaa gctcttcggc ttctgcccga cccgagctga 1020
ctcgacggtg atggggggca actcggcggg ggagctgtgc gtcttcccct tcactttcct 1080
gggtaaggag tactcgacct gtaccagcga gggccgcgga gatgggcgcc tctggtgcgc 1140
taccacctcg aactttgaca gcgacaagaa gtggggcttc tgcccggacc aaggatacag 1200
tttgttcctc gtggcggcgc atgagttcgg ccacgcgctg ggcttagatc attcctcagt 1260
gccggaggcg ctcatgtacc ctatgtaccg cttcactgag gggcccccct tgcataagga 1320
cgacgtgaat ggcatccggc acctctatgg tcctcgccct gaacctgagc cacggcctcc 1380
aaccaccacc acaccgcagc ccacggctcc cccgacggtc tgccccaccg gaccccccac 1440
tgtccacccc tcagagcgcc ccacagctgg ccccacaggt cccccctcag ctggccccac 1500
aggtcccccc actgctggcc cttctacggc cactactgtg cctttgagtc cggtggacga 1560
tgcctgcaac gtgaacatct tcgacgccat cgcggagatt gggaaccagc tgtatttgtt 1620
caaggatggg aagtactggc gattctctga gggcaggggg agccggccgc agggcccctt 1680
ccttatcgcc gacaagtggc ccgcgctgcc ccgcaagctg gactcggtct ttgaggagcg 1740
gctctccaag aagcttttct tcttctctgg gcgccaggtg tgggtgtaca caggcgcgtc 1800
ggtgctgggc ccgaggcgtc tggacaagct gggcctggga gccgacgtgg cccaggtgac 1860
cggggccctc cggagtggca gggggaagat gctgctgttc agcgggcggc gcctctggag 1920
gttcgacgtg aaggcgcaga tggtggatcc ccggagcgcc agcgaggtgg accggatgtt 1980
ccccggggtg cctttggaca cgcacgacgt cttccagtac cgagagaaag cctatttctg 2040
ccaggaccgc ttctactggc gcgtgagttc ccggagtgag ttgaaccagg tggaccaagt 2100
gggctacgtg acctatgaca tcctgcagtg ccctgaggac tagggctccc gtcctgcttt 2160
ggcagtgcca tgtaaatccc cactgggacc aaccctgggg aaggagccag tttgccggat 2220
acaaactggt attctgttct ggaggaaagg gaggagtgga ggtgggctgg gccctctctt 2280
ctcacctttg ttttttgttg gagtgtttct aataaacttg gattctctaa cctttaaaaa 2340
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa               2387

<210> 113
<211> 707
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-9 precursor

<400> 113
Met Ser Leu Trp Gln Pro Leu Val Leu Val Leu Leu Val Leu Gly Cys
 1               5                  10                  15      
Cys Phe Ala Ala Pro Arg Gln Arg Gln Ser Thr Leu Val Leu Phe Pro
            20                  25                  30          
Gly Asp Leu Arg Thr Asn Leu Thr Asp Arg Gln Leu Ala Glu Glu Tyr
        35                  40                  45              
Leu Tyr Arg Tyr Gly Tyr Thr Arg Val Ala Glu Met Arg Gly Glu Ser
    50                  55                  60                  
Lys Ser Leu Gly Pro Ala Leu Leu Leu Leu Gln Lys Gln Leu Ser Leu
65                  70                  75                  80  
Pro Glu Thr Gly Glu Leu Asp Ser Ala Thr Leu Lys Ala Met Arg Thr
                85                  90                  95      
Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr Phe Glu Gly
            100                 105                 110         
Asp Leu Lys Trp His His His Asn Ile Thr Tyr Trp Ile Gln Asn Tyr
        115                 120                 125             
Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe Ala Arg Ala
    130                 135                 140                 
Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr Arg Val Tyr
145                 150                 155                 160 
Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala Glu His Gly
                165                 170                 175     
Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala His Ala Phe
            180                 185                 190         
Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Asp Asp Glu
        195                 200                 205             
Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro Thr Arg Phe Gly Asn
    210                 215                 220                 
Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile Phe Glu Gly Arg Ser
225                 230                 235                 240 
Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu Pro Trp Cys
                245                 250                 255     
Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly Phe Cys Pro
            260                 265                 270         
Ser Glu Arg Leu Tyr Thr Gln Asp Gly Asn Ala Asp Gly Lys Pro Cys
        275                 280                 285             
Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala Cys Thr Thr
    290                 295                 300                 
Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr Ala Asn Tyr
305                 310                 315                 320 
Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala Asp Ser Thr
                325                 330                 335     
Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe Pro Phe Thr
            340                 345                 350         
Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly Arg Gly Asp
        355                 360                 365             
Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser Asp Lys Lys
    370                 375                 380                 
Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val Ala Ala
385                 390                 395                 400 
His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser Val Pro Glu
                405                 410                 415     
Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro Pro Leu His
            420                 425                 430         
Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly Pro Arg Pro Glu
        435                 440                 445             
Pro Glu Pro Arg Pro Pro Thr Thr Thr Thr Pro Gln Pro Thr Ala Pro
    450                 455                 460                 
Pro Thr Val Cys Pro Thr Gly Pro Pro Thr Val His Pro Ser Glu Arg
465                 470                 475                 480 
Pro Thr Ala Gly Pro Thr Gly Pro Pro Ser Ala Gly Pro Thr Gly Pro
                485                 490                 495     
Pro Thr Ala Gly Pro Ser Thr Ala Thr Thr Val Pro Leu Ser Pro Val
            500                 505                 510         
Asp Asp Ala Cys Asn Val Asn Ile Phe Asp Ala Ile Ala Glu Ile Gly
        515                 520                 525             
Asn Gln Leu Tyr Leu Phe Lys Asp Gly Lys Tyr Trp Arg Phe Ser Glu
    530                 535                 540                 
Gly Arg Gly Ser Arg Pro Gln Gly Pro Phe Leu Ile Ala Asp Lys Trp
545                 550                 555                 560 
Pro Ala Leu Pro Arg Lys Leu Asp Ser Val Phe Glu Glu Arg Leu Ser
                565                 570                 575     
Lys Lys Leu Phe Phe Phe Ser Gly Arg Gln Val Trp Val Tyr Thr Gly
            580                 585                 590         
Ala Ser Val Leu Gly Pro Arg Arg Leu Asp Lys Leu Gly Leu Gly Ala
        595                 600                 605             
Asp Val Ala Gln Val Thr Gly Ala Leu Arg Ser Gly Arg Gly Lys Met
    610                 615                 620                 
Leu Leu Phe Ser Gly Arg Arg Leu Trp Arg Phe Asp Val Lys Ala Gln
625                 630                 635                 640 
Met Val Asp Pro Arg Ser Ala Ser Glu Val Asp Arg Met Phe Pro Gly
                645                 650                 655     
Val Pro Leu Asp Thr His Asp Val Phe Gln Tyr Arg Glu Lys Ala Tyr
            660                 665                 670         
Phe Cys Gln Asp Arg Phe Tyr Trp Arg Val Ser Ser Arg Ser Glu Leu
        675                 680                 685             
Asn Gln Val Asp Gln Val Gly Tyr Val Thr Tyr Asp Ile Leu Gln Cys
    690                 695                 700                 
Pro Glu Asp
705         


<210> 114
<211> 614
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-9 mature

<400> 114
Met Arg Thr Pro Arg Cys Gly Val Pro Asp Leu Gly Arg Phe Gln Thr
 1               5                  10                  15      
Phe Glu Gly Asp Leu Lys Trp His His His Asn Ile Thr Tyr Trp Ile
            20                  25                  30          
Gln Asn Tyr Ser Glu Asp Leu Pro Arg Ala Val Ile Asp Asp Ala Phe
        35                  40                  45              
Ala Arg Ala Phe Ala Leu Trp Ser Ala Val Thr Pro Leu Thr Phe Thr
    50                  55                  60                  
Arg Val Tyr Ser Arg Asp Ala Asp Ile Val Ile Gln Phe Gly Val Ala
65                  70                  75                  80  
Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala
                85                  90                  95      
His Ala Phe Pro Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp
            100                 105                 110         
Asp Asp Glu Leu Trp Ser Leu Gly Lys Gly Val Val Val Pro Thr Arg
        115                 120                 125             
Phe Gly Asn Ala Asp Gly Ala Ala Cys His Phe Pro Phe Ile Phe Glu
    130                 135                 140                 
Gly Arg Ser Tyr Ser Ala Cys Thr Thr Asp Gly Arg Ser Asp Gly Leu
145                 150                 155                 160 
Pro Trp Cys Ser Thr Thr Ala Asn Tyr Asp Thr Asp Asp Arg Phe Gly
                165                 170                 175     
Phe Cys Pro Ser Glu Arg Leu Tyr Thr Arg Asp Gly Asn Ala Asp Gly
            180                 185                 190         
Lys Pro Cys Gln Phe Pro Phe Ile Phe Gln Gly Gln Ser Tyr Ser Ala
        195                 200                 205             
Cys Thr Thr Asp Gly Arg Ser Asp Gly Tyr Arg Trp Cys Ala Thr Thr
    210                 215                 220                 
Ala Asn Tyr Asp Arg Asp Lys Leu Phe Gly Phe Cys Pro Thr Arg Ala
225                 230                 235                 240 
Asp Ser Thr Val Met Gly Gly Asn Ser Ala Gly Glu Leu Cys Val Phe
                245                 250                 255     
Pro Phe Thr Phe Leu Gly Lys Glu Tyr Ser Thr Cys Thr Ser Glu Gly
            260                 265                 270         
Arg Gly Asp Gly Arg Leu Trp Cys Ala Thr Thr Ser Asn Phe Asp Ser
        275                 280                 285             
Asp Lys Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu
    290                 295                 300                 
Val Ala Ala His Glu Phe Gly His Ala Leu Gly Leu Asp His Ser Ser
305                 310                 315                 320 
Val Pro Glu Ala Leu Met Tyr Pro Met Tyr Arg Phe Thr Glu Gly Pro
                325                 330                 335     
Pro Leu His Lys Asp Asp Val Asn Gly Ile Arg His Leu Tyr Gly Pro
            340                 345                 350         
Arg Pro Glu Pro Glu Pro Arg Pro Pro Thr Thr Thr Thr Pro Gln Pro
        355                 360                 365             
Thr Ala Pro Pro Thr Val Cys Pro Thr Gly Pro Pro Thr Val His Pro
    370                 375                 380                 
Ser Glu Arg Pro Thr Ala Gly Pro Thr Gly Pro Pro Ser Ala Gly Pro
385                 390                 395                 400 
Thr Gly Pro Pro Thr Ala Gly Pro Ser Thr Ala Thr Thr Val Pro Leu
                405                 410                 415     
Ser Pro Val Asp Asp Ala Cys Asn Val Asn Ile Phe Asp Ala Ile Ala
            420                 425                 430         
Glu Ile Gly Asn Gln Leu Tyr Leu Phe Lys Asp Gly Lys Tyr Trp Arg
        435                 440                 445             
Phe Ser Glu Gly Arg Gly Ser Arg Pro Gln Gly Pro Phe Leu Ile Ala
    450                 455                 460                 
Asp Lys Trp Pro Ala Leu Pro Arg Lys Leu Asp Ser Val Phe Glu Glu
465                 470                 475                 480 
Pro Leu Ser Lys Lys Leu Phe Phe Phe Ser Gly Arg Gln Val Trp Val
                485                 490                 495     
Tyr Thr Gly Ala Ser Val Leu Gly Pro Arg Arg Leu Asp Lys Leu Gly
            500                 505                 510         
Leu Gly Ala Asp Val Ala Gln Val Thr Gly Ala Leu Arg Ser Gly Arg
        515                 520                 525             
Gly Lys Met Leu Leu Phe Ser Gly Arg Arg Leu Trp Arg Phe Asp Val
    530                 535                 540                 
Lys Ala Gln Met Val Asp Pro Arg Ser Ala Ser Glu Val Asp Arg Met
545                 550                 555                 560 
Phe Pro Gly Val Pro Leu Asp Thr His Asp Val Phe Gln Tyr Arg Glu
                565                 570                 575     
Lys Ala Tyr Phe Cys Gln Asp Arg Phe Tyr Trp Arg Val Ser Ser Arg
            580                 585                 590         
Ser Glu Leu Asn Gln Val Asp Gln Val Gly Tyr Val Thr Tyr Asp Ile
        595                 600                 605             
Leu Gln Cys Pro Glu Asp
    610                 


<210> 115
<211> 1828
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-3

<400> 115
ctacaaggag gcaggcaaga cagcaaggca tagagacaac atagagctaa gtaaagccag 60
tggaaatgaa gagtcttcca atcctactgt tgctgtgcgt ggcagtttgc tcagcctatc 120
cattggatgg agctgcaagg ggtgaggaca ccagcatgaa ccttgttcag aaatatctag 180
aaaactacta cgacctcaaa aaagatgtga aacagtttgt taggagaaag gacagtggtc 240
ctgttgttaa aaaaatccga gaaatgcaga agttccttgg attggaggtg acggggaagc 300
tggactccga cactctggag gtgatgcgca agcccaggtg tggagttcct gatgttggtc 360
acttcagaac ctttcctggc atcccgaagt ggaggaaaac ccaccttaca tacaggattg 420
tgaattatac accagatttg ccaaaagatg ctgttgattc tgctgttgag aaagctctga 480
aagtctggga agaggtgact ccactcacat tctccaggct gtatgaagga gaggctgata 540
taatgatctc ttttgcagtt agagaacatg gagactttta cccttttgat ggacctggaa 600
atgttttggc ccatgcctat gcccctgggc cagggattaa tggagatgcc cactttgatg 660
atgatgaaca atggacaaag gatacaacag ggaccaattt atttctcgtt gctgctcatg 720
aaattggcca ctccctgggt ctctttcact cagccaacac tgaagctttg atgtacccac 780
tctatcactc actcacagac ctgactcggt tccgcctgtc tcaagatgat ataaatggca 840
ttcagtccct ctatggacct ccccctgact cccctgagac ccccctggta cccacggaac 900
ctgtccctcc agaacctggg acgccagcca actgtgatcc tgctttgtcc tttgatgctg 960
tcagcactct gaggggagaa atcctgatct ttaaagacag gcacttttgg cgcaaatccc 1020
tcaggaagct tgaacctgaa ttgcatttga tctcttcatt ttggccatct cttccttcag 1080
gcgtggatgc cgcatatgaa gttactagca aggacctcgt tttcattttt aaaggaaatc 1140
aattctgggc tatcagagga aatgaggtac gagctggata cccaagaggc atccacaccc 1200
taggtttccc tccaaccgtg aggaaaatcg atgcagccat ttctgataag gaaaagaaca 1260
aaacatattt ctttgtagag gacaaatact ggagatttga tgagaagaga aattccatgg 1320
agccaggctt tcccaagcaa atagctgaag actttccagg gattgactca aagattgatg 1380
ctgtttttga agaatttggg ttcttttatt tctttactgg atcttcacag ttggagtttg 1440
acccaaatgc aaagaaagtg acacacactt tgaagagtaa cagctggctt aattgttgaa 1500
agagatatgt agaaggcaca atatgggcac tttaaatgaa gctaataatt cttcacctaa 1560
gtctctgtga attgaaatgt tcgttttctc ctgcctgtgc tgtgactcga gtcacactca 1620
agggaacttg agcgtgaatc tgtatcttgc cggtcatttt tatgttatta cagggcattc 1680
aaatgggctg ctgcttagct tgcaccttgt cacatagagt gatctttccc aagagaaggg 1740
gaagcactcg tgtgcaacag acaagtgact gtatctgtgt agactatttg cttatttaat 1800
aaagacgatt tgtcagttat tttatctt                                    1828

<210> 116
<211> 477
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-3 precursor

<400> 116
Met Lys Ser Leu Pro Ile Leu Leu Leu Leu Cys Val Ala Val Cys Ser
 1               5                  10                  15      
Ala Tyr Pro Leu Asp Gly Ala Ala Arg Gly Glu Asp Thr Ser Met Asn
            20                  25                  30          
Leu Val Gln Lys Tyr Leu Glu Asn Tyr Tyr Asp Leu Lys Lys Asp Val
        35                  40                  45              
Lys Gln Phe Val Arg Arg Lys Asp Ser Gly Pro Val Val Lys Lys Ile
    50                  55                  60                  
Arg Glu Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Leu Asp
65                  70                  75                  80  
Ser Asp Thr Leu Glu Val Met Arg Lys Pro Arg Cys Gly Val Pro Asp
                85                  90                  95      
Val Gly His Phe Arg Thr Phe Pro Gly Ile Pro Lys Trp Arg Lys Thr
            100                 105                 110         
His Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Lys Asp
        115                 120                 125             
Ala Val Asp Ser Ala Val Glu Lys Ala Leu Lys Val Trp Glu Glu Val
    130                 135                 140                 
Thr Pro Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met
145                 150                 155                 160 
Ile Ser Phe Ala Val Arg Glu His Gly Asp Phe Tyr Pro Phe Asp Gly
                165                 170                 175     
Pro Gly Asn Val Leu Ala His Ala Tyr Ala Pro Gly Pro Gly Ile Asn
            180                 185                 190         
Gly Asp Ala His Phe Asp Asp Asp Glu Gln Trp Thr Lys Asp Thr Thr
        195                 200                 205             
Gly Thr Asn Leu Phe Leu Val Ala Ala His Glu Ile Gly His Ser Leu
    210                 215                 220                 
Gly Leu Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr
225                 230                 235                 240 
His Ser Leu Thr Asp Leu Thr Arg Phe Arg Leu Ser Gln Asp Asp Ile
                245                 250                 255     
Asn Gly Ile Gln Ser Leu Tyr Gly Pro Pro Pro Asp Ser Pro Glu Thr
            260                 265                 270         
Pro Leu Val Pro Thr Glu Pro Val Pro Pro Glu Pro Gly Thr Pro Ala
        275                 280                 285             
Asn Cys Asp Pro Ala Leu Ser Phe Asp Ala Val Ser Thr Leu Arg Gly
    290                 295                 300                 
Glu Ile Leu Ile Phe Lys Asp Arg His Phe Trp Arg Lys Ser Leu Arg
305                 310                 315                 320 
Lys Leu Glu Pro Glu Leu His Leu Ile Ser Ser Phe Trp Pro Ser Leu
                325                 330                 335     
Pro Ser Gly Val Asp Ala Ala Tyr Glu Val Thr Ser Lys Asp Leu Val
            340                 345                 350         
Phe Ile Phe Lys Gly Asn Gln Phe Trp Ala Ile Arg Gly Asn Glu Val
        355                 360                 365             
Arg Ala Gly Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr
    370                 375                 380                 
Val Arg Lys Ile Asp Ala Ala Ile Ser Asp Lys Glu Lys Asn Lys Thr
385                 390                 395                 400 
Tyr Phe Phe Val Glu Asp Lys Tyr Trp Arg Phe Asp Glu Lys Arg Asn
                405                 410                 415     
Ser Met Glu Pro Gly Phe Pro Lys Gln Ile Ala Glu Asp Phe Pro Gly
            420                 425                 430         
Ile Asp Ser Lys Ile Asp Ala Val Phe Glu Glu Phe Gly Phe Phe Tyr
        435                 440                 445             
Phe Phe Thr Gly Ser Ser Gln Leu Glu Phe Asp Pro Asn Ala Lys Lys
    450                 455                 460                 
Val Thr His Thr Leu Lys Ser Asn Ser Trp Leu Asn Cys
465                 470                 475         


<210> 117
<211> 378
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-3 mature

<400> 117

Phe Arg Thr Phe Pro Gly Ile Pro Lys Trp Arg Lys Thr His Leu Thr
 1               5                  10                  15      
Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Lys Asp Ala Val Asp
            20                  25                  30          
Ser Ala Val Glu Lys Ala Leu Lys Val Trp Glu Glu Val Thr Pro Leu
        35                  40                  45              
Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met Ile Ser Phe
    50                  55                  60                  
Ala Val Arg Glu His Gly Asp Phe Tyr Pro Phe Asp Gly Pro Gly Asn
65                  70                  75                  80  
Val Leu Ala His Ala Tyr Ala Pro Gly Pro Gly Ile Asn Gly Asp Ala
                85                  90                  95      
His Phe Asp Asp Asp Glu Gln Trp Thr Lys Asp Thr Thr Gly Thr Asn
            100                 105                 110         
Leu Phe Leu Val Ala Ala His Glu Ile Gly His Ser Leu Gly Leu Phe
        115                 120                 125             
His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr His Ser Leu
    130                 135                 140                 
Thr Asp Leu Thr Arg Phe Arg Leu Ser Gln Asp Asp Ile Asn Gly Ile
145                 150                 155                 160 
Gln Ser Leu Tyr Gly Pro Pro Pro Asp Ser Pro Glu Thr Pro Leu Val
                165                 170                 175     
Pro Thr Glu Pro Val Pro Pro Glu Pro Gly Thr Pro Ala Asn Cys Asp
            180                 185                 190         
Pro Ala Leu Ser Phe Asp Ala Val Ser Thr Leu Arg Gly Glu Ile Leu
        195                 200                 205             
Ile Phe Lys Asp Arg His Phe Trp Arg Lys Ser Leu Arg Lys Leu Glu
    210                 215                 220                 
Pro Glu Leu His Leu Ile Ser Ser Phe Trp Pro Ser Leu Pro Ser Gly
225                 230                 235                 240 
Val Asp Ala Ala Tyr Glu Val Thr Ser Lys Asp Leu Val Phe Ile Phe
                245                 250                 255     
Lys Gly Asn Gln Phe Trp Ala Ile Arg Gly Asn Glu Val Arg Ala Gly
            260                 265                 270         
Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr Val Arg Lys
        275                 280                 285             
Ile Asp Ala Ala Ile Ser Asp Lys Glu Lys Asn Lys Thr Tyr Phe Phe
    290                 295                 300                 
Val Glu Asp Lys Tyr Trp Arg Phe Asp Glu Lys Arg Asn Ser Met Glu
305                 310                 315                 320 
Pro Gly Phe Pro Lys Gln Ile Ala Glu Asp Phe Pro Gly Ile Asp Ser
                325                 330                 335     
Lys Ile Asp Ala Val Phe Glu Glu Phe Gly Phe Phe Tyr Phe Phe Thr

            340                 345                 350         
Gly Ser Ser Gln Leu Glu Phe Asp Pro Asn Ala Lys Lys Val Thr His
        355                 360                 365             
Thr Leu Lys Ser Asn Ser Trp Leu Asn Cys
    370                 375             


<210> 118
<211> 1743
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-10

<400> 118
aaagaaggta agggcagtga gaatgatgca tcttgcattc cttgtgctgt tgtgtctgcc 60
agtctgctct gcctatcctc tgagtggggc agcaaaagag gaggactcca acaaggatct 120
tgcccagcaa tacctagaaa agtactacaa cctcgaaaag gatgtgaaac agtttagaag 180
aaaggacagt aatctcattg ttaaaaaaat ccaaggaatg cagaagttcc ttgggttgga 240
ggtgacaggg aagctagaca ctgacactct ggaggtgatg cgcaagccca ggtgtggagt 300
tcctgacgtt ggtcacttca gctcctttcc tggcatgccg aagtggagga aaacccacct 360
tacatacagg attgtgaatt atacaccaga tttgccaaga gatgctgttg attctgccat 420
tgagaaagct ctgaaagtct gggaagaggt gactccactc acattctcca ggctgtatga 480
aggagaggct gatataatga tctctttcgc agttaaagaa catggagact tttactcttt 540
tgatggccca ggacacagtt tggctcatgc ctacccacct ggacctgggc tttatggaga 600
tattcacttt gatgatgatg aaaaatggac agaagatgca tcaggcacca atttattcct 660
cgttgctgct catgaacttg gccactccct ggggctcttt cactcagcca acactgaagc 720
tttgatgtac ccactctaca actcattcac agagctcgcc cagttccgcc tttcgcaaga 780
tgatgtgaat ggcattcagt ctctctacgg acctccccct gcctctactg aggaacccct 840
ggtgcccaca aaatctgttc cttcgggatc tgagatgcca gccaagtgtg atcctgcttt 900
gtccttcgat gccatcagca ctctgagggg agaatatctg ttctttaaag acagatattt 960
ttggcgaaga tcccactgga accctgaacc tgaatttcat ttgatttctg cattttggcc 1020
ctctcttcca tcatatttgg atgctgcata tgaagttaac agcagggaca ccgtttttat 1080
ttttaaagga aatgagttct gggccatcag aggaaatgag gtacaagcag gttatccaag 1140
aggcatccat accctgggtt ttcctccaac cataaggaaa attgatgcag ctgtttctga 1200
caaggaaaag aagaaaacat acttctttgc agcggacaaa tactggagat ttgatgaaaa 1260
tagccagtcc atggagcaag gcttccctag actaatagct gatgactttc caggagttga 1320
gcctaaggtt gatgctgtat tacaggcatt tggatttttc tacttcttca gtggatcatc 1380
acagtttgag tttgacccca atgccaggat ggtgacacac atattaaaga gtaacagctg 1440
gttacattgc taggcgagat agggggaaga cagatatggg tgtttttaat aaatctaata 1500
attattcatc taatgtatta tgagccaaaa tggttaattt ttcctgcatg ttctgtgact 1560
gaagaagatg agccttgcag atatctgcat gtgtcatgaa gaatgtttct ggaattcttc 1620
acttgctttt gaattgcact gaacagaatt aagaaatact catgtgcaat aggtgagaga 1680
atgtattttc atagatgtgt tattacttcc tcaataaaaa gttttatttt gggcctgttc 1740
ctt                                                               1743

<210> 119
<211> 476
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-10 precursor

<400> 119
Met Met His Leu Ala Phe Leu Val Leu Leu Cys Leu Pro Val Cys Ser
 1               5                  10                  15      
Ala Tyr Pro Leu Ser Gly Ala Ala Lys Glu Glu Asp Ser Asn Lys Asp

            20                  25                  30          
Leu Ala Gln Gln Tyr Leu Glu Lys Tyr Tyr Asn Leu Glu Lys Asp Val
        35                  40                  45              
Lys Gln Phe Arg Arg Lys Asp Ser Asn Leu Ile Val Lys Lys Ile Gln
    50                  55                  60                  
Gly Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Leu Asp Thr
65                  70                  75                  80  
Asp Thr Leu Glu Val Met Arg Lys Pro Arg Cys Gly Val Pro Asp Val
                85                  90                  95      
Gly His Phe Ser Ser Phe Pro Gly Met Pro Lys Trp Arg Lys Thr His
            100                 105                 110         
Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Arg Asp Ala
        115                 120                 125             
Val Asp Ser Ala Ile Glu Lys Ala Leu Lys Val Trp Glu Glu Val Thr
    130                 135                 140                 
Pro Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met Ile
145                 150                 155                 160 
Ser Phe Ala Val Lys Glu His Gly Asp Phe Tyr Ser Phe Asp Gly Pro
                165                 170                 175     
Gly His Ser Leu Ala His Ala Tyr Pro Pro Gly Pro Gly Leu Tyr Gly
            180                 185                 190         
Asp Ile His Phe Asp Asp Asp Glu Lys Trp Thr Glu Asp Ala Ser Gly
        195                 200                 205             
Thr Asn Leu Phe Leu Val Ala Ala His Glu Leu Gly His Ser Leu Gly
    210                 215                 220                 
Leu Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr Asn
225                 230                 235                 240 
Ser Phe Thr Glu Leu Ala Gln Phe Arg Leu Ser Gln Asp Asp Val Asn
                245                 250                 255     
Gly Ile Gln Ser Leu Tyr Gly Pro Pro Pro Ala Ser Thr Glu Glu Pro
            260                 265                 270         
Leu Val Pro Thr Lys Ser Val Pro Ser Gly Ser Glu Met Pro Ala Lys
        275                 280                 285             
Cys Asp Pro Ala Leu Ser Phe Asp Ala Ile Ser Thr Leu Arg Gly Glu
    290                 295                 300                 
Tyr Leu Phe Phe Lys Asp Arg Tyr Phe Trp Arg Arg Ser His Trp Asn
305                 310                 315                 320 
Pro Glu Pro Glu Phe His Leu Ile Ser Ala Phe Trp Pro Ser Leu Pro
                325                 330                 335     
Ser Tyr Leu Asp Ala Ala Tyr Glu Val Asn Ser Arg Asp Thr Val Phe
            340                 345                 350         
Ile Phe Lys Gly Asn Glu Phe Trp Ala Ile Arg Gly Asn Glu Val Gln
        355                 360                 365             
Ala Gly Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr Ile
    370                 375                 380                 
Arg Lys Ile Asp Ala Ala Val Ser Asp Lys Glu Lys Lys Lys Thr Tyr
385                 390                 395                 400 
Phe Phe Ala Ala Asp Lys Tyr Trp Arg Phe Asp Glu Asn Ser Gln Ser
                405                 410                 415     
Met Glu Gln Gly Phe Pro Arg Leu Ile Ala Asp Asp Phe Pro Gly Val
            420                 425                 430         
Glu Pro Lys Val Asp Ala Val Leu Gln Ala Phe Gly Phe Phe Tyr Phe
        435                 440                 445             
Phe Ser Gly Ser Ser Gln Phe Glu Phe Asp Pro Asn Ala Arg Met Val
    450                 455                 460                 
Thr His Ile Leu Lys Ser Asn Ser Trp Leu His Cys
465                 470                 475     


<210> 120
<211> 378
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-10 mature

<400> 120
Phe Ser Ser Phe Pro Gly Met Pro Lys Trp Arg Lys Thr His Leu Thr
 1               5                  10                  15      
Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Arg Asp Ala Val Asp
            20                  25                  30          
Ser Ala Ile Glu Lys Ala Leu Lys Val Trp Glu Glu Val Thr Pro Leu
        35                  40                  45              
Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met Ile Ser Phe
    50                  55                  60                  
Ala Val Lys Glu His Gly Asp Phe Tyr Ser Phe Asp Gly Pro Gly His
65                  70                  75                  80  
Ser Leu Ala His Ala Tyr Pro Pro Gly Pro Gly Leu Tyr Gly Asp Ile
                85                  90                  95      
His Phe Asp Asp Asp Glu Lys Trp Thr Glu Asp Ala Ser Gly Thr Asn
            100                 105                 110         
Leu Phe Leu Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Phe
        115                 120                 125             
His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr Asn Ser Phe
    130                 135                 140                 
Thr Glu Leu Ala Gln Phe Arg Leu Ser Gln Asp Asp Val Asn Gly Ile
145                 150                 155                 160 
Gln Ser Leu Tyr Gly Pro Pro Pro Ala Ser Thr Glu Glu Pro Leu Val
                165                 170                 175     
Pro Thr Lys Ser Val Pro Ser Gly Ser Glu Met Pro Ala Lys Cys Asp
            180                 185                 190         
Pro Ala Leu Ser Phe Asp Ala Ile Ser Thr Leu Arg Gly Glu Tyr Leu
        195                 200                 205             
Phe Phe Lys Asp Arg Tyr Phe Trp Arg Arg Ser His Trp Asn Pro Glu
    210                 215                 220                 
Pro Glu Phe His Leu Ile Ser Ala Phe Trp Pro Ser Leu Pro Ser Tyr
225                 230                 235                 240 
Leu Asp Ala Ala Tyr Glu Val Asn Ser Arg Asp Thr Val Phe Ile Phe
                245                 250                 255     
Lys Gly Asn Glu Phe Trp Ala Ile Arg Gly Asn Glu Val Gln Ala Gly
            260                 265                 270         
Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr Ile Arg Lys
        275                 280                 285             
Ile Asp Ala Ala Val Ser Asp Lys Glu Lys Lys Lys Thr Tyr Phe Phe
    290                 295                 300                 
Ala Ala Asp Lys Tyr Trp Arg Phe Asp Glu Asn Ser Gln Ser Met Glu
305                 310                 315                 320 
Gln Gly Phe Pro Arg Leu Ile Ala Asp Asp Phe Pro Gly Val Glu Pro
                325                 330                 335     
Lys Val Asp Ala Val Leu Gln Ala Phe Gly Phe Phe Tyr Phe Phe Ser
            340                 345                 350         
Gly Ser Ser Gln Phe Glu Phe Asp Pro Asn Ala Arg Met Val Thr His
        355                 360                 365             
Ile Leu Lys Ser Asn Ser Trp Leu His Cys
    370                 375             


<210> 121
<211> 2247
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-11

<400> 121
ccggggcgga tggctccggc cgcctggctc cgcagcgcgg ccgcgcgcgc cctcctgccc 60
ccgatgctgc tgctgctgct ccagccgccg ccgctgctgg cccgggctct gccgccggac 120
gtccaccacc tccatgccga gaggaggggg ccacagccct ggcatgcagc cctgcccagt 180
agcccggcac ctgcccctgc cacgcaggaa gccccccggc ctgccagcag cctcaggcct 240
ccccgctgtg gcgtgcccga cccatctgat gggctgagtg cccgcaaccg acagaagagg 300
ttcgtgcttt ctggcgggcg ctgggagaag acggacctca cctacaggat ccttcggttc 360
ccatggcagt tggtgcagga gcaggtgcgg cagacgatgg cagaggccct aaaggtatgg 420
agcgatgtga cgccactcac ctttactgag gtgcacgagg gccgtgctga catcatgatc 480
gacttcgcca ggtactggca tggggacgac ctgccgtttg atgggcctgg gggcatcctg 540
gcccatgcct tcttccccaa gactcaccga gaaggggatg tccacttcga ctatgatgag 600
acctggacta tcggggatga ccagggcaca gacctgctgc aggtggcagc ccatgaattt 660
ggccacgtgc tggggctgca gcacacaaca gcagccaagg ccctgatgtc cgccttctac 720
acctttcgct acccactgag tctcagccca gatgactgca ggggcgttca acacctatat 780
ggccagccct ggcccactgt cacctccagg accccagccc tgggccccca ggctgggata 840
gacaccaatg agattgcacc gctggagcca gacgccccgc cagatgcctg tgaggcctcc 900
tttgacgcgg tctccaccat ccgaggcgag ctctttttct tcaaagcggg ctttgtgtgg 960
cgcctccgtg ggggccagct gcagcccggc tacccagcat tggcctctcg ccactggcag 1020
ggactgccca gccctgtgga cgctgccttc gaggatgccc agggccacat ttggttcttc 1080
caaggtgctc agtactgggt gtacgacggt gaaaagccag tcctgggccc cgcacccctc 1140
accgagctgg gcctggtgag gttcccggtc catgctgcct tggtctgggg tcccgagaag 1200
aacaagatct acttcttccg aggcagggac tactggcgtt tccaccccag cacccggcgt 1260
gtagacagtc ccgtgccccg cagggccact gactggagag gggtgccctc tgagatcgac 1320
gctgccttcc aggatgctga tggctatgcc tacttcctgc gcggccgcct ctactggaag 1380
tttgaccctg tgaaggtgaa ggctctggaa ggcttccccc gtctcgtggg tcctgacttc 1440
tttggctgtg ccgagcctgc caacactttc ctctgaccat ggcttggatg ccctcagggg 1500
tgctgacccc tgccaggcca cgaatatcag gctagagacc catggccatc tttgtggctg 1560
tgggcaccag gcatgggact gagcccatgt ctcctgcagg gggatggggt ggggtacaac 1620
caccatgaca actgccggga gggccacgca ggtcgtggtc acctgccagc gactgtctca 1680
gactgggcag ggaggctttg gcatgactta agaggaaggg cagtcttggg acccgctatg 1740
caggtcctgg caaacctggc tgccctgtct catccctgtc cctcagggta gcaccatggc 1800
aggactgggg gaactggagt gtccttgctg tatccctgtt gtgaggttcc ttccaggggc 1860
tggcactgaa gcaagggtgc tggggcccca tggccttcag ccctggctga gcaactgggc 1920
tgtagggcag ggccacttcc tgaggtcagg tcttggtagg tgcctgcatc tgtctgcctt 1980
ctggctgaca atcctggaaa tctgttctcc agaatccagg ccaaaaagtt cacagtcaaa 2040
tggggagggg tattcttcat gcaggagacc ccaggccctg gaggctgcaa catacctcaa 2100
tcctgtccca ggccggatcc tcctgaagcc cttttcgcag cactgctatc ctccaaagcc 2160
attgtaaatg tgtgtacagt gtgtataaac cttcttcttc tttttttttt ttaaactgag 2220
gattgtcatt aaacacagtt gttttct                                     2247

<210> 122
<211> 488
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-11 precursor

<400> 122
Met Ala Pro Ala Ala Trp Leu Arg Ser Ala Ala Ala Arg Ala Leu Leu
 1               5                  10                  15      
Pro Pro Met Leu Leu Leu Leu Leu Gln Pro Pro Pro Leu Leu Ala Arg
            20                  25                  30          
Ala Leu Pro Pro Asp Val His His Leu His Ala Glu Arg Arg Gly Pro
        35                  40                  45              
Gln Pro Trp His Ala Ala Leu Pro Ser Ser Pro Ala Pro Ala Pro Ala
    50                  55                  60                  
Thr Gln Glu Ala Pro Arg Pro Ala Ser Ser Leu Arg Pro Pro Arg Cys
65                  70                  75                  80  
Gly Val Pro Asp Pro Ser Asp Gly Leu Ser Ala Arg Asn Arg Gln Lys
                85                  90                  95      
Arg Phe Val Leu Ser Gly Gly Arg Trp Glu Lys Thr Asp Leu Thr Tyr
            100                 105                 110         
Arg Ile Leu Arg Phe Pro Trp Gln Leu Val Gln Glu Gln Val Arg Gln
        115                 120                 125             
Thr Met Ala Glu Ala Leu Lys Val Trp Ser Asp Val Thr Pro Leu Thr
    130                 135                 140                 
Phe Thr Glu Val His Glu Gly Arg Ala Asp Ile Met Ile Asp Phe Ala
145                 150                 155                 160 
Arg Tyr Trp His Gly Asp Asp Leu Pro Phe Asp Gly Pro Gly Gly Ile
                165                 170                 175     
Leu Ala His Ala Phe Phe Pro Lys Thr His Arg Glu Gly Asp Val His
            180                 185                 190         
Phe Asp Tyr Asp Glu Thr Trp Thr Ile Gly Asp Asp Gln Gly Thr Asp
        195                 200                 205             
Leu Leu Gln Val Ala Ala His Glu Phe Gly His Val Leu Gly Leu Gln
    210                 215                 220                 
His Thr Thr Ala Ala Lys Ala Leu Met Ser Ala Phe Tyr Thr Phe Arg
225                 230                 235                 240 
Tyr Pro Leu Ser Leu Ser Pro Asp Asp Cys Arg Gly Val Gln His Leu
                245                 250                 255     
Tyr Gly Gln Pro Trp Pro Thr Val Thr Ser Arg Thr Pro Ala Leu Gly
            260                 265                 270         
Pro Gln Ala Gly Ile Asp Thr Asn Glu Ile Ala Pro Leu Glu Pro Asp
        275                 280                 285             
Ala Pro Pro Asp Ala Cys Glu Ala Ser Phe Asp Ala Val Ser Thr Ile
    290                 295                 300                 
Arg Gly Glu Leu Phe Phe Phe Lys Ala Gly Phe Val Trp Arg Leu Arg
305                 310                 315                 320 
Gly Gly Gln Leu Gln Pro Gly Tyr Pro Ala Leu Ala Ser Arg His Trp
                325                 330                 335     
Gln Gly Leu Pro Ser Pro Val Asp Ala Ala Phe Glu Asp Ala Gln Gly
            340                 345                 350         
His Ile Trp Phe Phe Gln Gly Ala Gln Tyr Trp Val Tyr Asp Gly Glu
        355                 360                 365             
Lys Pro Val Leu Gly Pro Ala Pro Leu Thr Glu Leu Gly Leu Val Arg
    370                 375                 380                 
Phe Pro Val His Ala Ala Leu Val Trp Gly Pro Glu Lys Asn Lys Ile
385                 390                 395                 400 
Tyr Phe Phe Arg Gly Arg Asp Tyr Trp Arg Phe His Pro Ser Thr Arg
                405                 410                 415     
Arg Val Asp Ser Pro Val Pro Arg Arg Ala Thr Asp Trp Arg Gly Val
            420                 425                 430         
Pro Ser Glu Ile Asp Ala Ala Phe Gln Asp Ala Asp Gly Tyr Ala Tyr
        435                 440                 445             
Phe Leu Arg Gly Arg Leu Tyr Trp Lys Phe Asp Pro Val Lys Val Lys
    450                 455                 460                 
Ala Leu Glu Gly Phe Pro Arg Leu Val Gly Pro Asp Phe Phe Gly Cys
465                 470                 475                 480 
Ala Glu Pro Ala Asn Thr Phe Leu
                485             


<210> 123
<211> 391
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-11 mature

<400> 123
Phe Val Leu Ser Gly Gly Arg Trp Glu Lys Thr Asp Leu Thr Tyr Arg
 1               5                  10                  15      
Ile Leu Arg Phe Pro Trp Gln Leu Val Gln Glu Gln Val Arg Gln Thr
            20                  25                  30          
Met Ala Glu Ala Leu Lys Val Trp Ser Asp Val Thr Pro Leu Thr Phe
        35                  40                  45              
Thr Glu Val His Glu Gly Arg Ala Asp Ile Met Ile Asp Phe Ala Arg
    50                  55                  60                  
Tyr Trp His Gly Asp Asp Leu Pro Phe Asp Gly Pro Gly Gly Ile Leu
65                  70                  75                  80  
Ala His Ala Phe Phe Pro Lys Thr His Arg Glu Gly Asp Val His Phe
                85                  90                  95      
Asp Tyr Asp Glu Thr Trp Thr Ile Gly Asp Asp Gln Gly Thr Asp Leu
            100                 105                 110         
Leu Gln Val Ala Ala His Glu Phe Gly His Val Leu Gly Leu Gln His
        115                 120                 125             
Thr Thr Ala Ala Lys Ala Leu Met Ser Ala Phe Tyr Thr Phe Arg Tyr
    130                 135                 140                 
Pro Leu Ser Leu Ser Pro Asp Asp Cys Arg Gly Val Gln His Leu Tyr
145                 150                 155                 160 
Gly Gln Pro Trp Pro Thr Val Thr Ser Arg Thr Pro Ala Leu Gly Pro
                165                 170                 175     
Gln Ala Gly Ile Asp Thr Asn Glu Ile Ala Pro Leu Glu Pro Asp Ala
            180                 185                 190         
Pro Pro Asp Ala Cys Glu Ala Ser Phe Asp Ala Val Ser Thr Ile Arg
        195                 200                 205             

Gly Glu Leu Phe Phe Phe Lys Ala Gly Phe Val Trp Arg Leu Arg Gly
    210                 215                 220                 
Gly Gln Leu Gln Pro Gly Tyr Pro Ala Leu Ala Ser Arg His Trp Gln
225                 230                 235                 240 
Gly Leu Pro Ser Pro Val Asp Ala Ala Phe Glu Asp Ala Gln Gly His
                245                 250                 255     
Ile Trp Phe Phe Gln Gly Ala Gln Tyr Trp Val Tyr Asp Gly Glu Lys
            260                 265                 270         
Pro Val Leu Gly Pro Ala Pro Leu Thr Glu Leu Gly Leu Val Arg Phe
        275                 280                 285             
Pro Val His Ala Ala Leu Val Trp Gly Pro Glu Lys Asn Lys Ile Tyr
    290                 295                 300                 
Phe Phe Arg Gly Arg Asp Tyr Trp Arg Phe His Pro Ser Thr Arg Arg
305                 310                 315                 320 
Val Asp Ser Pro Val Pro Arg Arg Ala Thr Asp Trp Arg Gly Val Pro
                325                 330                 335     
Ser Glu Ile Asp Ala Ala Phe Gln Asp Ala Asp Gly Tyr Ala Tyr Phe
            340                 345                 350         
Leu Arg Gly Arg Leu Tyr Trp Lys Phe Asp Pro Val Lys Val Lys Ala
        355                 360                 365             
Leu Glu Gly Phe Pro Arg Leu Val Gly Pro Asp Phe Phe Gly Cys Ala
    370                 375                 380                 
Glu Pro Ala Asn Thr Phe Leu
385                 390     


<210> 124
<211> 1147
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-7

<400> 124
accaaatcaa ccataggtcc aagaacaatt gtctctggac ggcagctatg cgactcaccg 60
tgctgtgtgc tgtgtgcctg ctgcctggca gcctggccct gccgctgcct caggaggcgg 120
gaggcatgag tgagctacag tgggaacagg ctcaggacta tctcaagaga ttttatctct 180
atgactcaga aacaaaaaat gccaacagtt tagaagccaa actcaaggag atgcaaaaat 240
tctttggcct acctataact ggaatgttaa actcccgcgt catagaaata atgcagaagc 300
ccagatgtgg agtgccagat gttgcagaat actcactatt tccaaatagc ccaaaatgga 360
cttccaaagt ggtcacctac aggatcgtat catatactcg agacttaccg catattacag 420
tggatcgatt agtgtcaaag gctttaaaca tgtggggcaa agagatcccc ctgcatttca 480
ggaaagttgt atggggaact gctgacatca tgattggctt tgcgcgagga gctcatgggg 540
actcctaccc atttgatggg ccaggaaaca cgctggctca tgcctttgcg cctgggacag 600
gtctcggagg agatgctcac ttcgatgagg atgaacgctg gacggatggt agcagtctag 660
ggattaactt cctgtatgct gcaactcatg aacttggcca ttctttgggt atgggacatt 720
cctctgatcc taatgcagtg atgtatccaa cctatggaaa tggagatccc caaaatttta 780
aactttccca ggatgatatt aaaggcattc agaaactata tggaaagaga agtaattcaa 840
gaaagaaata gaaacttcag gcagaacatc cattcattca ttcattggat tgtatatcat 900
tgttgcacaa tcagaattga taagcactgt tcctccactc catttagcaa ttatgtcacc 960
cttttttatt gcagttggtt tttgaatgtc tttcactcct tttaaggata aactccttta 1020
tggtgtgact gtgtcttatt catctatact tgcagtgggt agatgtcaat aaatgttaca 1080
tacacaaata aataaaatgt ttattccatg gtaaatttaa aaaaaaaaaa aaaaaaaaaa 1140
aaaaaaa                                                           1147

<210> 125
<211> 267
<212> PRT
<213> Homo sapiens


<220> 
<223> MMP-7 precursor

<400> 125
Met Arg Leu Thr Val Leu Cys Ala Val Cys Leu Leu Pro Gly Ser Leu
 1               5                  10                  15      
Ala Leu Pro Leu Pro Gln Glu Ala Gly Gly Met Ser Glu Leu Gln Trp
            20                  25                  30          
Glu Gln Ala Gln Asp Tyr Leu Lys Arg Phe Tyr Leu Tyr Asp Ser Glu
        35                  40                  45              
Thr Lys Asn Ala Asn Ser Leu Glu Ala Lys Leu Lys Glu Met Gln Lys
    50                  55                  60                  
Phe Phe Gly Leu Pro Ile Thr Gly Met Leu Asn Ser Arg Val Ile Glu
65                  70                  75                  80  
Ile Met Gln Lys Pro Arg Cys Gly Val Pro Asp Val Ala Glu Tyr Ser
                85                  90                  95      
Leu Phe Pro Asn Ser Pro Lys Trp Thr Ser Lys Val Val Thr Tyr Arg
            100                 105                 110         
Ile Val Ser Tyr Thr Arg Asp Leu Pro His Ile Thr Val Asp Arg Leu
        115                 120                 125             
Val Ser Lys Ala Leu Asn Met Trp Gly Lys Glu Ile Pro Leu His Phe
    130                 135                 140                 
Arg Lys Val Val Trp Gly Thr Ala Asp Ile Met Ile Gly Phe Ala Arg
145                 150                 155                 160 
Gly Ala His Gly Asp Ser Tyr Pro Phe Asp Gly Pro Gly Asn Thr Leu
                165                 170                 175     
Ala His Ala Phe Ala Pro Gly Thr Gly Leu Gly Gly Asp Ala His Phe
            180                 185                 190         
Asp Glu Asp Glu Arg Trp Thr Asp Gly Ser Ser Leu Gly Ile Asn Phe
        195                 200                 205             
Leu Tyr Ala Ala Thr His Glu Leu Gly His Ser Leu Gly Met Gly His
    210                 215                 220                 
Ser Ser Asp Pro Asn Ala Val Met Tyr Pro Thr Tyr Gly Asn Gly Asp
225                 230                 235                 240 
Pro Gln Asn Phe Lys Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Lys
                245                 250                 255     
Leu Tyr Gly Lys Arg Ser Asn Ser Arg Lys Lys
            260                 265         


<210> 126
<211> 173
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-7 mature

<400> 126
Tyr Ser Leu Phe Pro Asn Ser Pro Lys Trp Thr Ser Lys Val Val Thr
 1               5                  10                  15      
Tyr Arg Ile Val Ser Tyr Thr Arg Asp Leu Pro His Ile Thr Val Asp
            20                  25                  30          
Arg Leu Val Ser Lys Ala Leu Asn Met Trp Gly Lys Glu Ile Pro Leu
        35                  40                  45              
His Phe Arg Lys Val Val Trp Gly Thr Ala Asp Ile Met Ile Gly Phe
    50                  55                  60                  
Ala Arg Gly Ala His Gly Asp Ser Tyr Pro Phe Asp Gly Pro Gly Asn
65                  70                  75                  80  
Thr Leu Ala His Ala Phe Ala Pro Gly Thr Gly Leu Gly Gly Asp Ala
                85                  90                  95      
His Phe Asp Glu Asp Glu Arg Trp Thr Asp Gly Ser Ser Leu Gly Ile
            100                 105                 110         
Asn Phe Leu Tyr Ala Ala Thr His Glu Leu Gly His Ser Leu Gly Met
        115                 120                 125             
Gly His Ser Ser Asp Pro Asn Ala Val Met Tyr Pro Thr Tyr Gly Asn
    130                 135                 140                 
Gly Asp Pro Gln Asn Phe Lys Leu Ser Gln Asp Asp Ile Lys Gly Ile
145                 150                 155                 160 
Gln Lys Leu Tyr Gly Lys Arg Ser Asn Ser Arg Lys Lys
                165                 170             


<210> 127
<211> 998
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-26

<400> 127
gacaaatgag ggtttggcat gcagctcgtc atcttaagag ttactatctt cttgccctgg 60
tgtttcgccg ttccagtgcc ccctgctgca gaccataaag gatgggactt tgttgagggc 120
tatttccatc aatttttcct gaccaagaag gagtcgccac tccttaccca ggagacacaa 180
acacagctcc tgcaacaatt ccatcggaat gggacagacc tacttgacat gcagatgcat 240
gctctgctac accagcccca ctgtggggtg cctgatgggt ccgacacctc catctcgcca 300
ggaagatgca agtggaataa gcacactcta acttacagga ttatcaatta cccacatgat 360
atgaagccat ccgcagtgaa agacagtata tataatgcag tttccatctg gagcaatgtg 420
acccctttga tattccagca agtgcagaat ggagatgcag acatcaaggt ttctttctgg 480
cagtgggccc atgaagatgg ttggcccttt gatgggccag gtggtatctt aggccatgcc 540
tttttaccaa attctggaaa tcctggagtt gtccattttg acaagaatga acactggtca 600
gcttcagaca ctggatataa tctgttcctg gttgcaactc atgagattgg gcattctttg 660
ggcctgcagc actctgggaa tcagagctcc ataatgtacc ccacttactg gtatcacgac 720
cctagaacct tccagctcag tgccgatgat atccaaagga tccagcattt gtatggagaa 780
aaatgttcat ctgacatacc ttaatgttag cacagaggac ttattcaacc tgtcctttca 840
gggagtttat tggaggatca aagaactgaa agcactagag cagccttggg gactgctagg 900
atgaagccct aaagaatgca acctagtcag gttagctgaa ccgacactca aaacgctact 960
gagtcacaat aaagattgtt ttaaagagta aaaaaaaa                         998

<210> 128
<211> 261
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-26 precursor

<400> 128
Met Gln Leu Val Ile Leu Arg Val Thr Ile Phe Leu Pro Trp Cys Phe
 1               5                  10                  15      
Ala Val Pro Val Pro Pro Ala Ala Asp His Lys Gly Trp Asp Phe Val
            20                  25                  30          
Glu Gly Tyr Phe His Gln Phe Phe Leu Thr Lys Lys Glu Ser Pro Leu
        35                  40                  45              
Leu Thr Gln Glu Thr Gln Thr Gln Leu Leu Gln Gln Phe His Arg Asn
    50                  55                  60                  
Gly Thr Asp Leu Leu Asp Met Gln Met His Ala Leu Leu His Gln Pro
65                  70                  75                  80  
His Cys Gly Val Pro Asp Gly Ser Asp Thr Ser Ile Ser Pro Gly Arg
                85                  90                  95      
Cys Lys Trp Asn Lys His Thr Leu Thr Tyr Arg Ile Ile Asn Tyr Pro
            100                 105                 110         
His Asp Met Lys Pro Ser Ala Val Lys Asp Ser Ile Tyr Asn Ala Val
        115                 120                 125             
Ser Ile Trp Ser Asn Val Thr Pro Leu Ile Phe Gln Gln Val Gln Asn
    130                 135                 140                 
Gly Asp Ala Asp Ile Lys Val Ser Phe Trp Gln Trp Ala His Glu Asp
145                 150                 155                 160 
Gly Trp Pro Phe Asp Gly Pro Gly Gly Ile Leu Gly His Ala Phe Leu
                165                 170                 175     
Pro Asn Ser Gly Asn Pro Gly Val Val His Phe Asp Lys Asn Glu His
            180                 185                 190         
Trp Ser Ala Ser Asp Thr Gly Tyr Asn Leu Phe Leu Val Ala Thr His
        195                 200                 205             
Glu Ile Gly His Ser Leu Gly Leu Gln His Ser Gly Asn Gln Ser Ser
    210                 215                 220                 
Ile Met Tyr Pro Thr Tyr Trp Tyr His Asp Pro Arg Thr Phe Gln Leu
225                 230                 235                 240 
Ser Ala Asp Asp Ile Gln Arg Ile Gln His Leu Tyr Gly Glu Lys Cys
                245                 250                 255     
Ser Ser Asp Ile Pro
            260     


<210> 129
<211> 172
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-26 mature

<400> 129
Thr Ser Ile Ser Pro Gly Arg Cys Lys Trp Asn Lys His Thr Leu Thr
 1               5                  10                  15      
Tyr Arg Ile Ile Asn Tyr Pro His Asp Met Lys Pro Ser Ala Val Lys
            20                  25                  30          
Asp Ser Ile Tyr Asn Ala Val Ser Ile Trp Ser Asn Val Thr Pro Leu
        35                  40                  45              
Ile Phe Gln Gln Val Gln Asn Gly Asp Ala Asp Ile Lys Val Ser Phe
    50                  55                  60                  
Trp Gln Trp Ala His Glu Asp Gly Trp Pro Phe Asp Gly Pro Gly Gly
65                  70                  75                  80  
Ile Leu Gly His Ala Phe Leu Pro Asn Ser Gly Asn Pro Gly Val Val
                85                  90                  95      
His Phe Asp Lys Asn Glu His Trp Ser Ala Ser Asp Thr Gly Tyr Asn
            100                 105                 110         
Leu Phe Leu Val Ala Thr His Glu Ile Gly His Ser Leu Gly Leu Gln
        115                 120                 125             
His Ser Gly Asn Gln Ser Ser Ile Met Tyr Pro Thr Tyr Trp Tyr His
    130                 135                 140                 
Asp Pro Arg Thr Phe Gln Leu Ser Ala Asp Asp Ile Gln Arg Ile Gln
145                 150                 155                 160 
His Leu Tyr Gly Glu Lys Cys Ser Ser Asp Ile Pro
                165                 170         


<210> 130
<211> 1825
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-12

<400> 130
agaaaggaac acagtaaact gaattgatcc gtttagaagt ttacaatgaa gtttcttcta 60
atactgctcc tgcaggccac tgcttctgga gctcttcccc tgaacagctc tacaagcctg 120
gaaaaaaata atgtgctatt tggtgaaaga tacttagaaa aattttatgg ccttgagata 180
aacaaacttc cagtgacaaa aatgaaatat agtggaaact taatgaagga aaaaatccaa 240
gaaatgcagc acttcttggg tctgaaagtg accgggcaac tggacacatc taccctggag 300
atgatgcacg cacctcgatg tggagtcccc gatgtccatc atttcaggga aatgccaggg 360
gggcccgtat ggaggaaaca ttatatcacc tacagaatca ataattacac acctgacatg 420
aaccgtgagg atgttgacta cgcaatccgg aaagctttcc aagtatggag taatgttacc 480
cccttgaaat tcagcaagat taacacaggc atggctgaca ttttggtggt ttttgcccgt 540
ggagctcatg gagacttcca tgcttttgat ggcaaaggtg gaatcctagc ccatgctttt 600
ggacctggat ctggcattgg aggggatgca catttcgatg aggacgaatt ctggactaca 660
cattcaggag gcaccaactt gttcctcact gctgttcacg agattggcca ttccttaggt 720
cttggccatt ctagtgatcc aaaggccgta atgttcccca cctacaaata tgttgacatc 780
aacacatttc gcctctctgc tgatgacata cgtggcattc agtccctgta tggagaccca 840
aaagagaacc aacgcttgcc aaatcctgac aattcagaac cagctctctg tgaccccaat 900
ttgagttttg atgctgtcac taccgtggga aataagatct ttttcttcaa agacaggttc 960
ttctggctga aggtttctga gagaccaaag accagtgtta atttaatttc ttccttatgg 1020
ccaaccttgc catctggcat tgaagctgct tatgaaattg aagccagaaa tcaagttttt 1080
ctttttaaag atgacaaata ctggttaatt agcaatttaa gaccagagcc aaattatccc 1140
aagagcatac attcttttgg ttttcctaac tttgtgaaaa aaattgatgc agctgttttt 1200
aacccacgtt tttataggac ctacttcttt gtagataacc agtattggag gtatgatgaa 1260
aggagacaga tgatggaccc tggttatccc aaactgatta ccaagaactt ccaaggaatc 1320
gggcctaaaa ttgatgcagt cttctactct aaaaacaaat actactattt cttccaagga 1380
tctaaccaat ttgaatatga cttcctactc caacgtatca ccaaaacact gaaaagcaat 1440
agctggtttg gttgttagaa atggtgtaat taatggtttt tgttagttca cttcagctta 1500
ataagtattt attgcatatt tgctatgtcc tcagtgtacc actacttaga gatatgtatc 1560
ataaaaataa aatctgtaaa ccataggtaa tgattatata aaatacataa tatttttcaa 1620
ttttgaaaac tctaattgtc cattcttgct tgactctact attaagtttg aaaatagtta 1680
ccttcaaagg ccaagagaat tctatttgaa gcatgctctg taagttgctt cctaacatcc 1740
ttggactgag aaattatact tacttctggc ataactaaaa ttaagtatat atattttggc 1800
tcaaataaaa ttgaaaaaaa aatca                                       1825

<210> 131
<211> 470
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-12 precursor

<400> 131
Met Lys Phe Leu Leu Ile Leu Leu Leu Gln Ala Thr Ala Ser Gly Ala
 1               5                  10                  15      
Leu Pro Leu Asn Ser Ser Thr Ser Leu Glu Lys Asn Asn Val Leu Phe
            20                  25                  30          
Gly Glu Arg Tyr Leu Glu Lys Phe Tyr Gly Leu Glu Ile Asn Lys Leu
        35                  40                  45              
Pro Val Thr Lys Met Lys Tyr Ser Gly Asn Leu Met Lys Glu Lys Ile
    50                  55                  60                  
Gln Glu Met Gln His Phe Leu Gly Leu Lys Val Thr Gly Gln Leu Asp
65                  70                  75                  80  
Thr Ser Thr Leu Glu Met Met His Ala Pro Arg Cys Gly Val Pro Asp
                85                  90                  95      
Val His His Phe Arg Glu Met Pro Gly Gly Pro Val Trp Arg Lys His
            100                 105                 110         
Tyr Ile Thr Tyr Arg Ile Asn Asn Tyr Thr Pro Asp Met Asn Arg Glu
        115                 120                 125             
Asp Val Asp Tyr Ala Ile Arg Lys Ala Phe Gln Val Trp Ser Asn Val
    130                 135                 140                 
Thr Pro Leu Lys Phe Ser Lys Ile Asn Thr Gly Met Ala Asp Ile Leu
145                 150                 155                 160 
Val Val Phe Ala Arg Gly Ala His Gly Asp Phe His Ala Phe Asp Gly
                165                 170                 175     
Lys Gly Gly Ile Leu Ala His Ala Phe Gly Pro Gly Ser Gly Ile Gly
            180                 185                 190         
Gly Asp Ala His Phe Asp Glu Asp Glu Phe Trp Thr Thr His Ser Gly
        195                 200                 205             
Gly Thr Asn Leu Phe Leu Thr Ala Val His Glu Ile Gly His Ser Leu
    210                 215                 220                 
Gly Leu Gly His Ser Ser Asp Pro Lys Ala Val Met Phe Pro Thr Tyr
225                 230                 235                 240 
Lys Tyr Val Asp Ile Asn Thr Phe Arg Leu Ser Ala Asp Asp Ile Arg
                245                 250                 255     
Gly Ile Gln Ser Leu Tyr Gly Asp Pro Lys Glu Asn Gln Arg Leu Pro
            260                 265                 270         
Asn Pro Asp Asn Ser Glu Pro Ala Leu Cys Asp Pro Asn Leu Ser Phe
        275                 280                 285             
Asp Ala Val Thr Thr Val Gly Asn Lys Ile Phe Phe Phe Lys Asp Arg
    290                 295                 300                 
Phe Phe Trp Leu Lys Val Ser Glu Arg Pro Lys Thr Ser Val Asn Leu
305                 310                 315                 320 
Ile Ser Ser Leu Trp Pro Thr Leu Pro Ser Gly Ile Glu Ala Ala Tyr
                325                 330                 335     
Glu Ile Glu Ala Arg Asn Gln Val Phe Leu Phe Lys Asp Asp Lys Tyr
            340                 345                 350         
Trp Leu Ile Ser Asn Leu Arg Pro Glu Pro Asn Tyr Pro Lys Ser Ile
        355                 360                 365             
His Ser Phe Gly Phe Pro Asn Phe Val Lys Lys Ile Asp Ala Ala Val
    370                 375                 380                 
Phe Asn Pro Arg Phe Tyr Arg Thr Tyr Phe Phe Val Asp Asn Gln Tyr
385                 390                 395                 400 
Trp Arg Tyr Asp Glu Arg Arg Gln Met Met Asp Pro Gly Tyr Pro Lys
                405                 410                 415     
Leu Ile Thr Lys Asn Phe Gln Gly Ile Gly Pro Lys Ile Asp Ala Val
            420                 425                 430         
Phe Tyr Ser Lys Asn Lys Tyr Tyr Tyr Phe Phe Gln Gly Ser Asn Gln
        435                 440                 445             
Phe Glu Tyr Asp Phe Leu Leu Gln Arg Ile Thr Lys Thr Leu Lys Ser
    450                 455                 460                 
Asn Ser Trp Phe Gly Cys
465                 470 


<210> 132
<211> 365
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-12 mature

<400> 132
Gly Pro Val Trp Arg Lys His Tyr Ile Thr Tyr Arg Ile Asn Asn Tyr
 1               5                  10                  15      
Thr Pro Asp Met Asn Arg Glu Asp Val Asp Tyr Ala Ile Arg Lys Ala

            20                  25                  30          
Phe Gln Val Trp Ser Asn Val Thr Pro Leu Lys Phe Ser Lys Ile Asn
        35                  40                  45              
Thr Gly Met Ala Asp Ile Leu Val Val Phe Ala Arg Gly Ala His Gly
    50                  55                  60                  
Asp Phe His Ala Phe Asp Gly Lys Gly Gly Ile Leu Ala His Ala Phe
65                  70                  75                  80  
Gly Pro Gly Ser Gly Ile Gly Gly Asp Ala His Phe Asp Glu Asp Glu
                85                  90                  95      
Phe Trp Thr Thr His Ser Gly Gly Thr Asn Leu Phe Leu Thr Ala Val
            100                 105                 110         
His Glu Ile Gly His Ser Leu Gly Leu Gly His Ser Ser Asp Pro Lys
        115                 120                 125             
Ala Val Met Phe Pro Thr Tyr Lys Tyr Val Asp Ile Asn Thr Phe Arg
    130                 135                 140                 
Leu Ser Ala Asp Asp Ile Arg Gly Ile Gln Ser Leu Tyr Gly Asp Pro
145                 150                 155                 160 
Lys Glu Asn Gln Arg Leu Pro Asn Pro Asp Asn Ser Glu Pro Ala Leu
                165                 170                 175     
Cys Asp Pro Asn Leu Ser Phe Asp Ala Val Thr Thr Val Gly Asn Lys
            180                 185                 190         
Ile Phe Phe Phe Lys Asp Arg Phe Phe Trp Leu Lys Val Ser Glu Arg
        195                 200                 205             
Pro Lys Thr Ser Val Asn Leu Ile Ser Ser Leu Trp Pro Thr Leu Pro
    210                 215                 220                 
Ser Gly Ile Glu Ala Ala Tyr Glu Ile Glu Ala Arg Asn Gln Val Phe
225                 230                 235                 240 
Leu Phe Lys Asp Asp Lys Tyr Trp Leu Ile Ser Asn Leu Arg Pro Glu
                245                 250                 255     
Pro Asn Tyr Pro Lys Ser Ile His Ser Phe Gly Phe Pro Asn Phe Val
            260                 265                 270         
Lys Lys Ile Asp Ala Ala Val Phe Asn Pro Arg Phe Tyr Arg Thr Tyr
        275                 280                 285             
Phe Phe Val Asp Asn Gln Tyr Trp Arg Tyr Asp Glu Arg Arg Gln Met
    290                 295                 300                 
Met Asp Pro Gly Tyr Pro Lys Leu Ile Thr Lys Asn Phe Gln Gly Ile
305                 310                 315                 320 
Gly Pro Lys Ile Asp Ala Val Phe Tyr Ser Lys Asn Lys Tyr Tyr Tyr
                325                 330                 335     
Phe Phe Gln Gly Ser Asn Gln Phe Glu Tyr Asp Phe Leu Leu Gln Arg
            340                 345                 350         
Ile Thr Lys Thr Leu Lys Ser Asn Ser Trp Phe Gly Cys
        355                 360                 365 


<210> 133
<211> 3558
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-14

<400> 133
cagaccccag ttcgccgact aagcagaaga aagatcaaaa accggaaaag aggagaagag 60
caaacaggca ctttgaggaa caatcccctt taactccaag ccgacagcgg tctaggaatt 120
caagttcagt gcctaccgaa gacaaaggcg ccccgaggga gtggcggtgc gaccccaggg 180
cgtgggcccg gccgcggagc ccacactgcc cggctgaccc ggtggtctcg gaccatgtct 240
cccgccccaa gacccccccg ttgtctcctg ctccccctgc tcacgctcgg caccgcgctc 300
gcctccctcg gctcggccca aagcagcagc ttcagccccg aagcctggct acagcaatat 360
ggctacctgc ctcccgggga cctacgtacc cacacacagc gctcacccca gtcactctca 420
gcggccatcg ctgccatgca gaagttttac ggcttgcaag taacaggcaa agctgatgca 480
gacaccatga aggccatgag gcgcccccga tgtggtgttc cagacaagtt tggggctgag 540
atcaaggcca atgttcgaag gaagcgctac gccatccagg gtctcaaatg gcaacataat 600
gaaatcactt tctgcatcca gaattacacc cccaaggtgg gcgagtatgc cacatacgag 660
gccattcgca aggcgttccg cgtgtgggag agtgccacac cactgcgctt ccgcgaggtg 720
ccctatgcct acatccgtga gggccatgag aagcaggccg acatcatgat cttctttgcc 780
gagggcttcc atggcgacag cacgcccttc gatggtgagg gcggcttcct ggcccatgcc 840
tacttcccag gccccaacat tggaggagac acccactttg actctgccga gccttggact 900
gtcaggaatg aggatctgaa tggaaatgac atcttcctgg tggctgtgca cgagctgggc 960
catgccctgg ggctcgagca ttccagtgac ccctcggcca tcatggcacc cttttaccag 1020
tggatggaca cggagaattt tgtgctgccc gatgatgacc gccggggcat ccagcaactt 1080
tatgggggtg agtcagggtt ccccaccaag atgccccctc aacccaggac tacctcccgg 1140
ccttctgttc ctgataaacc caaaaacccc acctatgggc ccaacatctg tgacgggaac 1200
tttgacaccg tggccatgct ccgaggggag atgtttgtct tcaaggagcg ctggttctgg 1260
cgggtgagga ataaccaagt gatggatgga tacccaatgc ccattggcca gttctggcgg 1320
ggcctgcctg cgtccatcaa cactgcctac gagaggaagg atggcaaatt cgtcttcttc 1380
aaaggagaca agcattgggt gtttgatgag gcgtccctgg aacctggcta ccccaagcac 1440
attaaggagc tgggccgagg gctgcctacc gacaagattg atgctgctct cttctggatg 1500
cccaatggaa agacctactt cttccgtgga aacaagtact accgtttcaa cgaagagctc 1560
agggcagtgg atagcgagta ccccaagaac atcaaagtct gggaagggat ccctgagtct 1620
cccagagggt cattcatggg cagcgatgaa gtcttcactt acttctacaa ggggaacaaa 1680
tactggaaat tcaacaacca gaagctgaag gtagaaccgg gctaccccaa gtcagccctg 1740
agggactgga tgggctgccc atcgggaggc cggccggatg aggggactga ggaggagacg 1800
gaggtgatca tcattgaggt ggacgaggag ggcggcgggg cggtgagcgc ggctgccgtg 1860
gtgctgcccg tgctgctgct gctcctggtg ctggcggtgg gccttgcagt cttcttcttc 1920
agacgccatg ggacccccag gcgactgctc tactgccagc gttccctgct ggacaaggtc 1980
tgacgcccac cgccggcccg cccactccta ccacaaggac tttgcctctg aaggccagtg 2040
gcagcaggtg gtggtgggtg ggctgctccc atcgtcccga gccccctccc cgcagcctcc 2100
ttgcttctct ctgtcccctg gctggcctcc ttcaccctga ccgcctccct ccctcctgcc 2160
ccggcattgc atcttcccta gataggtccc ctgagggctg agtgggaggg cggccctttc 2220
cagcctctgc ccctcagggg aaccctgtag ctttgtgtct gtccagcccc atctgaatgt 2280
gttgggggct ctgcacttga aggcaggacc ctcagacctc gctggtaaag gtcaaatggg 2340
gtcatctgct ccttttccat cccctgacat accttaacct ctgaactctg acctcaggag 2400
gctctgggca ctccagccct gaaagcccca ggtgtaccca attggcagcc tctcactact 2460
ctttctggct aaaaggaatc taatcttgtt gagggtagag accctgagac agtgtgaggg 2520
ggtggggact gccaagccac cctaagacct tgggaggaaa actcagagag ggtcttcgtt 2580
gctcagtcag tcaagttcct cggagatctg cctctgcctc acctacccca gggaacttcc 2640
aaggaaggag cctgagccac tggggactaa gtgggcagaa gaaacccttg gcagccctgt 2700
gcctctcgaa tgttagcctt ggatggggct ttcacagtta gaagagctga aaccaggggt 2760
gcagctgtca ggtagggtgg ggccggtggg agaggcccgg gtcagagccc tgggggtgag 2820
cctgaaggcc acagagaaag aaccttgccc aaactcaggc agctggggct gaggcccaaa 2880
ggcagaacag ccagaggggg caggagggga ccaaaaagga aaatgaggac gtgcagcagc 2940
attggaaggc tggggccggg caggccaggc caagccaagc agggggccac agggtgggct 3000
gtggagctct caggaagggc cctgaggaag gcacacttgc tcctgttggt ccctgtcctt 3060
gctgcccagg cagcgtggag gggaagggta gggcagccag agaaaggagc agagaaggca 3120
cacaaacgag gaatgagggg cttcacgaga ggccacaggg cctggctggc cacgctgtcc 3180
cggcctgctc accatctcag tgaggggcag gagctggggc tcgcttaggc tgggtccacg 3240
cttccctggt gccagcaccc ctcaagcctg tctcaccagt ggcctgccct ctcgctcccc 3300
cacccagccc acccattgaa gtctccttgg gccaccaaag gtggtggcca tggtaccggg 3360
gacttgggag agtgagaccc agtggaggga gcaagaggag agggatgtcg ggggggtggg 3420
gcacggggta ggggaaatgg ggtgaacggt gctggcagtt cggctagatt tctgtcttgt 3480
ttgttttttt gttttgttta atgtatattt ttattataat tattatatat gaattccaaa 3540
aaaaaaaaaa aaaaaaaa                                               3558

<210> 134
<211> 582
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-14 precursor

<400> 134
Met Ser Pro Ala Pro Arg Pro Pro Arg Cys Leu Leu Leu Pro Leu Leu
 1               5                  10                  15      

Thr Leu Gly Thr Ala Leu Ala Ser Leu Gly Ser Ala Gln Ser Ser Ser
            20                  25                  30          
Phe Ser Pro Glu Ala Trp Leu Gln Gln Tyr Gly Tyr Leu Pro Pro Gly
        35                  40                  45              
Asp Leu Arg Thr His Thr Gln Arg Ser Pro Gln Ser Leu Ser Ala Ala
    50                  55                  60                  
Ile Ala Ala Met Gln Lys Phe Tyr Gly Leu Gln Val Thr Gly Lys Ala
65                  70                  75                  80  
Asp Ala Asp Thr Met Lys Ala Met Arg Arg Pro Arg Cys Gly Val Pro
                85                  90                  95      
Asp Lys Phe Gly Ala Glu Ile Lys Ala Asn Val Arg Arg Lys Arg Tyr
            100                 105                 110         
Ala Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys Ile
        115                 120                 125             
Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Tyr Glu Ala Ile
    130                 135                 140                 
Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe Arg
145                 150                 155                 160 
Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala Asp
                165                 170                 175     
Ile Met Ile Phe Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro Phe
            180                 185                 190         
Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Asn
        195                 200                 205             
Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val Arg
    210                 215                 220                 
Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His Glu
225                 230                 235                 240 
Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile
                245                 250                 255     
Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu Pro
            260                 265                 270         
Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Gly Glu Ser Gly
        275                 280                 285             
Phe Pro Thr Lys Met Pro Pro Gln Pro Arg Thr Thr Ser Arg Pro Ser
    290                 295                 300                 
Val Pro Asp Lys Pro Lys Asn Pro Thr Tyr Gly Pro Asn Ile Cys Asp
305                 310                 315                 320 
Gly Asn Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met Phe Val Phe
                325                 330                 335     
Lys Glu Arg Trp Phe Trp Arg Val Arg Asn Asn Gln Val Met Asp Gly
            340                 345                 350         
Tyr Pro Met Pro Ile Gly Gln Phe Trp Arg Gly Leu Pro Ala Ser Ile

        355                 360                 365             
Asn Thr Ala Tyr Glu Arg Lys Asp Gly Lys Phe Val Phe Phe Lys Gly
    370                 375                 380                 
Asp Lys His Trp Val Phe Asp Glu Ala Ser Leu Glu Pro Gly Tyr Pro
385                 390                 395                 400 
Lys His Ile Lys Glu Leu Gly Arg Gly Leu Pro Thr Asp Lys Ile Asp
                405                 410                 415     
Ala Ala Leu Phe Trp Met Pro Asn Gly Lys Thr Tyr Phe Phe Arg Gly
            420                 425                 430         
Asn Lys Tyr Tyr Arg Phe Asn Glu Glu Leu Arg Ala Val Asp Ser Glu
        435                 440                 445             
Tyr Pro Lys Asn Ile Lys Val Trp Glu Gly Ile Pro Glu Ser Pro Arg
    450                 455                 460                 
Gly Ser Phe Met Gly Ser Asp Glu Val Phe Thr Tyr Phe Tyr Lys Gly
465                 470                 475                 480 
Asn Lys Tyr Trp Lys Phe Asn Asn Gln Lys Leu Lys Val Glu Pro Gly
                485                 490                 495     
Tyr Pro Lys Ser Ala Leu Arg Asp Trp Met Gly Cys Pro Ser Gly Gly
            500                 505                 510         
Arg Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu Val Ile Ile Ile Glu
        515                 520                 525             
Val Asp Glu Glu Gly Gly Gly Ala Val Ser Ala Ala Ala Val Val Leu
    530                 535                 540                 
Pro Val Leu Leu Leu Leu Leu Val Leu Ala Val Gly Leu Ala Val Phe
545                 550                 555                 560 
Phe Phe Arg Arg His Gly Thr Pro Arg Arg Leu Leu Tyr Cys Gln Arg
                565                 570                 575     
Ser Leu Leu Asp Lys Val
            580         


<210> 135
<211> 471
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-14 mature

<400> 135
Tyr Ala Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys
 1               5                  10                  15      
Ile Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Tyr Glu Ala
            20                  25                  30          
Ile Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe
        35                  40                  45              
Arg Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala
    50                  55                  60                  
Asp Ile Met Ile Phe Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro
65                  70                  75                  80  
Phe Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro
                85                  90                  95      
Asn Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val
            100                 105                 110         
Arg Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His
        115                 120                 125             
Glu Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asp Pro Ser Ala
    130                 135                 140                 
Ile Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu
145                 150                 155                 160 
Pro Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Gly Glu Ser
                165                 170                 175     
Gly Phe Pro Thr Lys Met Pro Pro Gln Pro Arg Thr Thr Ser Arg Pro
            180                 185                 190         
Ser Val Pro Asp Lys Pro Lys Asn Pro Thr Tyr Gly Pro Asn Ile Cys
        195                 200                 205             
Asp Gly Asn Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met Phe Val
    210                 215                 220                 
Phe Lys Glu Arg Trp Phe Trp Arg Val Arg Asn Asn Gln Val Met Asp
225                 230                 235                 240 
Gly Tyr Pro Met Pro Ile Gly Gln Phe Trp Arg Gly Leu Pro Ala Ser
                245                 250                 255     
Ile Asn Thr Ala Tyr Glu Arg Lys Asp Gly Lys Phe Val Phe Phe Lys
            260                 265                 270         
Gly Asp Lys His Trp Val Phe Asp Glu Ala Ser Leu Glu Pro Gly Tyr
        275                 280                 285             
Pro Lys His Ile Lys Glu Leu Gly Arg Gly Leu Pro Thr Asp Lys Ile
    290                 295                 300                 
Asp Ala Ala Leu Phe Trp Met Pro Asn Gly Lys Thr Tyr Phe Phe Arg
305                 310                 315                 320 
Gly Asn Lys Tyr Tyr Arg Phe Asn Glu Glu Leu Arg Ala Val Asp Ser
                325                 330                 335     
Glu Tyr Pro Lys Asn Ile Lys Val Trp Glu Gly Ile Pro Glu Ser Pro
            340                 345                 350         
Arg Gly Ser Phe Met Gly Ser Asp Glu Val Phe Thr Tyr Phe Tyr Lys
        355                 360                 365             
Gly Asn Lys Tyr Trp Lys Phe Asn Asn Gln Lys Leu Lys Val Glu Pro
    370                 375                 380                 
Gly Tyr Pro Lys Ser Ala Leu Arg Asp Trp Met Gly Cys Pro Ser Gly
385                 390                 395                 400 
Gly Arg Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu Val Ile Ile Ile
                405                 410                 415     
Glu Val Asp Glu Glu Gly Gly Gly Ala Val Ser Ala Ala Ala Val Val
            420                 425                 430         
Leu Pro Val Leu Leu Leu Leu Leu Val Leu Ala Val Gly Leu Ala Val
        435                 440                 445             
Phe Phe Phe Arg Arg His Gly Thr Pro Arg Arg Leu Leu Tyr Cys Gln
    450                 455                 460                 
Arg Ser Leu Leu Asp Lys Val
465                 470     


<210> 136
<211> 4456
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-15

<400> 136
acgactcttt gatccctccc ctaagacctc cttcccgtcc gcctaggcct cggtatcccc 60
caccaggtat gagaaggagg agtcttcatt cttcccaggc ggggagacca cgccttccct 120
gcctcctccc tccgcggggg gtcgcgttgg aggtcacccc cgccccctag gcgctgggtt 180
gggagtgacg cggggtgggc tggagaggtt tcctgccgtc tgggaagcgt aaacggaccg 240
cccacctgtc gggcctcggc cgcccgcacc tgcttgtgag aagcctgcgg ctggggcacc 300
gcccccggtc cccgcccggg tccgcgcatt gggagcacac tggcccttta agagcgcggc 360
ggccgcggcg cgcggggagg agggctggga gcgcccggag ccgcgctgaa ctcgccgggg 420
acgtcgggcg cccgctcctt ggctggctcg cttgctctct cgctcgctct ctcgggtcgg 480
ctccctgcgc ctcctcccgg gactgcttgg ggacccgggc ccggtcgggc gcggcggcga 540
gcagaatccc cgtgcaggag gcgcgcgctc cgggcagcgc ccggccccgg gcatggacag 600
agggagctgg gcgcgcaggg agcgccgcgg gaccgggcgg ccggagcgct gagccagaca 660
aaggctccgg agttgcgctt gctctcggga gccgggcccc aggcgctggg cgccgaggct 720
gcggaacctc gccgggggca gctccggtcg gccccctttc ccgccggctg gttccgagct 780
cccggacctg ccctgcccgc ttctcctcgg gcttgggaat ttgccgaggc gacctaggcg 840
gctccggcgg ggaccgggag cccgaggtcc gcggcgcgcc tgccgggcca ggagccaggg 900
agcgtcgcaa gtttccaagg cgcgtgcgag gatccggcgt gcagtgttcc gagctgggct 960
gggcgccgag agcatgggca gcgacccgag cgcgcccgga cggccgggct ggacgggcag 1020
cctcctcggc gaccgggagg aggcggcgcg gccgcgactg ctgccgctgc tcctggtgct 1080
tctgggctgc ctgggccttg gcgtagcggc cgaagacgcg gaggtccatg ccgagaactg 1140
gctgcggctt tatggctacc tgcctcagcc cagccgccat atgtccacca tgcgttccgc 1200
ccagatcttg gcctcggccc ttgcagagat gcagcgcttc tacgggatcc cagtcaccgg 1260
tgtgctcgac gaagagacca aggagtggat gaagcggccc cgctgtgggg tgccagacca 1320
gttcggggta cgagtgaaag ccaacctgcg gcggcgtcgg aagcgctacg ccctcaccgg 1380
gaggaagtgg aacaaccacc atctgacctt tagcatccag aactacacgg agaagttggg 1440
ctggtaccac tcgatggagg cggtgcgcag ggccttccgc gtgtgggagc aggccacgcc 1500
cctggtcttc caggaggtgc cctatgagga catccggctg cggcgacaga aggaggccga 1560
catcatggta ctctttgcct ctggcttcca cggcgacagc tcgccgtttg atggcaccgg 1620
tggctttctg gcccacgcct atttccctgg ccccggccta ggcggggaca cccattttga 1680
cgcagatgag ccctggacct tctccagcac tgacctgcat ggaaacaacc tcttcctggt 1740
ggcagtgcat gagctgggcc acgcgctggg gctggagcac tccagcaacc ccaatgccat 1800
catggcgccg ttctaccagt ggaaggacgt tgacaacttc aagctgcccg aggacgatct 1860
ccgtggcatc cagcagctct acggtacccc agacggtcag ccacagccta cccagcctct 1920
ccccactgtg acgccacggc ggccaggccg gcctgaccac cggccgcccc ggcctcccca 1980
gccaccaccc ccaggtggga agccagagcg gcccccaaag ccgggccccc cagtccagcc 2040
ccgagccaca gagcggcccg accagtatgg ccccaacatc tgcgacgggg actttgacac 2100
agtggccatg cttcgcgggg agatgttcgt gttcaagggc cgctggttct ggcgagtccg 2160
gcacaaccgc gtcctggaca actatcccat gcccatcggg cacttctggc gtggtctgcc 2220
cggtgacatc agtgctgcct acgagcgcca agacggtcgt tttgtctttt tcaaaggtga 2280
ccgctactgg ctctttcgag aagcgaacct ggagcccggc tacccacagc cgctgaccag 2340
ctatggcctg ggcatcccct atgaccgcat tgacacggcc atctggtggg agcccacagg 2400
ccacaccttc ttcttccaag aggacaggta ctggcgcttc aacgaggaga cacagcgtgg 2460
agaccctggg taccccaagc ccatcagtgt ctggcagggg atccctgcct cccctaaagg 2520
ggccttcctg agcaatgacg cagcctacac ctacttctac aagggcacca aatactggaa 2580
attcgacaat gagcgcctgc ggatggagcc cggctacccc aagtccatcc tgcgggactt 2640
catgggctgc caggagcacg tggagccagg cccccgatgg cccgacgtgg cccggccgcc 2700
cttcaacccc cacgggggtg cagagcccgg ggcggacagc gcagagggcg acgtggggga 2760
tggggatggg gactttgggg ccggggtcaa caaggacggg ggcagccgcg tggtggtgca 2820
gatggaggag gtggcacgga cggtgaacgt ggtgatggtg ctggtgccac tgctgctgct 2880
gctctgcgtc ctgggcctca cctacgcgct ggtgcagatg cagcgcaagg gtgcgccacg 2940
tgtcctgctt tactgcaagc gctcgctgca ggagtgggtc tgaccaccca gcgctcctgc 3000
taacggtgct cagggggcgc ctgtggttct gagatggctc ccaggggctc cctccgcccc 3060
caggtagggg cccctctcag ccctcacaca ccctgtctgc cccgccctca ttatttatgt 3120
ccaggtgttt gttttgtttt gtttttggca ccttacttga ccatttgttt ctgtttcccc 3180
gactggggca gggtgtttag aattttctaa atgtagttct gctccagaca gggaattagg 3240
cccccatcat cctctggctt ggccacagcc aggggagcag aggggcagag gcccacattg 3300
gaagagcagc acctcctcag cctgaacccc agggctgtaa ctgccaggct ctctttgccc 3360
agttggagac tgtctggccc ccctggtccc ctccttccca agtgagtctc tctgggcctt 3420
aggaagagcc ttccacccag gggcagcccc aggccaaagg ggacctggaa gggaggtggg 3480
ccgtggccct tgagtcccca ttgaggcttg gttccttccc aatccagtgg acttcgcagt 3540
ccacttctga cagcctcagt gaccctggct ccttgtgcca gagaacccag cccacccccg 3600
gcagcagccc ccagctccca cctccccttg ggcccacacc tccttccctc tctggagaaa 3660
gggccctggg cctgcctcac cacggaccaa agggagtctg ccagggcccc tctccccagg 3720
gaagcagcag cctcgcccct ggcagagatg cctccctgag ctagaaccct ctgttccttc 3780
cctgtgcctc ctccctccct ctccgactca caccactagc ctcaggggtc tgagctccag 3840
ctcctttggg cttcagctgc cagtgtcctg agccccaggg agagggggct ggtgggtgcc 3900
taggcctggg cagtggatgg ccgtgaatgg gtgcccacag tgtcaggcac tgggcatgag 3960
gggttcctcc cctccagctc cctgtgcccc cagggtcctg ggaggagaga cactggtggg 4020
gataggccag ccgcgcatca gactgtgaac cccacgaagg agcccattgt ggcctaagag 4080
gctgccctcc tgtgctcagc cctgaggaca gatgcctcct tcctcttttc cttcccaaag 4140
caagcaagag gccgtggctg ctgtgggaaa tggtactgta cagctggctc tacttcccca 4200
tggccctgag cgagtggagt ctgccaccca ggatccccaa ggcacttgag ggggaaggat 4260
tctgctggcc tctgcgagtg gtttcttgtg cactggcacc aagtgcgggt ccggcagctt 4320
ctgccccctg cagaaccgga gagccagcta aggggtgggg ctgcgggggt tccgtgtcca 4380
cccccataca tttatttctg taaataatgt gcactgaata aattgtacag ccggcaaaaa 4440
aaaaaaaaaa aaaaaa                                                 4456

<210> 137
<211> 669
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-15 precursor

<400> 137
Met Gly Ser Asp Pro Ser Ala Pro Gly Arg Pro Gly Trp Thr Gly Ser
 1               5                  10                  15      
Leu Leu Gly Asp Arg Glu Glu Ala Ala Arg Pro Arg Leu Leu Pro Leu
            20                  25                  30          
Leu Leu Val Leu Leu Gly Cys Leu Gly Leu Gly Val Ala Ala Glu Asp
        35                  40                  45              
Ala Glu Val His Ala Glu Asn Trp Leu Arg Leu Tyr Gly Tyr Leu Pro
    50                  55                  60                  
Gln Pro Ser Arg His Met Ser Thr Met Arg Ser Ala Gln Ile Leu Ala
65                  70                  75                  80  
Ser Ala Leu Ala Glu Met Gln Arg Phe Tyr Gly Ile Pro Val Thr Gly
                85                  90                  95      
Val Leu Asp Glu Glu Thr Lys Glu Trp Met Lys Arg Pro Arg Cys Gly
            100                 105                 110         
Val Pro Asp Gln Phe Gly Val Arg Val Lys Ala Asn Leu Arg Arg Arg
        115                 120                 125             
Arg Lys Arg Tyr Ala Leu Thr Gly Arg Lys Trp Asn Asn His His Leu
    130                 135                 140                 
Thr Phe Ser Ile Gln Asn Tyr Thr Glu Lys Leu Gly Trp Tyr His Ser
145                 150                 155                 160 
Met Glu Ala Val Arg Arg Ala Phe Arg Val Trp Glu Gln Ala Thr Pro
                165                 170                 175     

Leu Val Phe Gln Glu Val Pro Tyr Glu Asp Ile Arg Leu Arg Arg Gln
            180                 185                 190         
Lys Glu Ala Asp Ile Met Val Leu Phe Ala Ser Gly Phe His Gly Asp
        195                 200                 205             
Ser Ser Pro Phe Asp Gly Thr Gly Gly Phe Leu Ala His Ala Tyr Phe
    210                 215                 220                 
Pro Gly Pro Gly Leu Gly Gly Asp Thr His Phe Asp Ala Asp Glu Pro
225                 230                 235                 240 
Trp Thr Phe Ser Ser Thr Asp Leu His Gly Asn Asn Leu Phe Leu Val
                245                 250                 255     
Ala Val His Glu Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asn
            260                 265                 270         
Pro Asn Ala Ile Met Ala Pro Phe Tyr Gln Trp Lys Asp Val Asp Asn
        275                 280                 285             
Phe Lys Leu Pro Glu Asp Asp Leu Arg Gly Ile Gln Gln Leu Tyr Gly
    290                 295                 300                 
Thr Pro Asp Gly Gln Pro Gln Pro Thr Gln Pro Leu Pro Thr Val Thr
305                 310                 315                 320 
Pro Arg Arg Pro Gly Arg Pro Asp His Arg Pro Pro Arg Pro Pro Gln
                325                 330                 335     
Pro Pro Pro Pro Gly Gly Lys Pro Glu Arg Pro Pro Lys Pro Gly Pro
            340                 345                 350         
Pro Val Gln Pro Arg Ala Thr Glu Arg Pro Asp Gln Tyr Gly Pro Asn
        355                 360                 365             
Ile Cys Asp Gly Asp Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met
    370                 375                 380                 
Phe Val Phe Lys Gly Arg Trp Phe Trp Arg Val Arg His Asn Arg Val
385                 390                 395                 400 
Leu Asp Asn Tyr Pro Met Pro Ile Gly His Phe Trp Arg Gly Leu Pro
                405                 410                 415     
Gly Asp Ile Ser Ala Ala Tyr Glu Arg Gln Asp Gly Arg Phe Val Phe
            420                 425                 430         
Phe Lys Gly Asp Arg Tyr Trp Leu Phe Arg Glu Ala Asn Leu Glu Pro
        435                 440                 445             
Gly Tyr Pro Gln Pro Leu Thr Ser Tyr Gly Leu Gly Ile Pro Tyr Asp
    450                 455                 460                 
Arg Ile Asp Thr Ala Ile Trp Trp Glu Pro Thr Gly His Thr Phe Phe
465                 470                 475                 480 
Phe Gln Glu Asp Arg Tyr Trp Arg Phe Asn Glu Glu Thr Gln Arg Gly
                485                 490                 495     
Asp Pro Gly Tyr Pro Lys Pro Ile Ser Val Trp Gln Gly Ile Pro Ala
            500                 505                 510         
Ser Pro Lys Gly Ala Phe Leu Ser Asn Asp Ala Ala Tyr Thr Tyr Phe

        515                 520                 525             
Tyr Lys Gly Thr Lys Tyr Trp Lys Phe Asp Asn Glu Arg Leu Arg Met
    530                 535                 540                 
Glu Pro Gly Tyr Pro Lys Ser Ile Leu Arg Asp Phe Met Gly Cys Gln
545                 550                 555                 560 
Glu His Val Glu Pro Gly Pro Arg Trp Pro Asp Val Ala Arg Pro Pro
                565                 570                 575     
Phe Asn Pro His Gly Gly Ala Glu Pro Gly Ala Asp Ser Ala Glu Gly
            580                 585                 590         
Asp Val Gly Asp Gly Asp Gly Asp Phe Gly Ala Gly Val Asn Lys Asp
        595                 600                 605             
Gly Gly Ser Arg Val Val Val Gln Met Glu Glu Val Ala Arg Thr Val
    610                 615                 620                 
Asn Val Val Met Val Leu Val Pro Leu Leu Leu Leu Leu Cys Val Leu
625                 630                 635                 640 
Gly Leu Thr Tyr Ala Leu Val Gln Met Gln Arg Lys Gly Ala Pro Arg
                645                 650                 655     
Val Leu Leu Tyr Cys Lys Arg Ser Leu Gln Glu Trp Val
            660                 665                 


<210> 138
<211> 529
<212> PRT
<213> Homo sapiens


<220> 
<223> MMP-15 mature

<400> 138
Tyr Ala Leu Thr Gly Arg Lys Trp Asn Asn His His Leu Thr Phe Ser
 1               5                  10                  15      
Ile Gln Asn Tyr Thr Glu Lys Leu Gly Trp Tyr His Ser Met Glu Ala
            20                  25                  30          
Val Arg Arg Ala Phe Arg Val Trp Glu Gln Ala Thr Pro Leu Val Phe
        35                  40                  45              
Gln Glu Val Pro Tyr Glu Asp Ile Arg Leu Arg Arg Gln Lys Glu Ala
    50                  55                  60                  
Asp Ile Met Val Leu Phe Ala Ser Gly Phe His Gly Asp Ser Ser Pro
65                  70                  75                  80  
Phe Asp Gly Thr Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro
                85                  90                  95      
Gly Leu Gly Gly Asp Thr His Phe Asp Ala Asp Glu Pro Trp Thr Phe
            100                 105                 110         
Ser Ser Thr Asp Leu His Gly Asn Asn Leu Phe Leu Val Ala Val His

        115                 120                 125             
Glu Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asn Pro Asn Ala
    130                 135                 140                 
Ile Met Ala Pro Phe Tyr Gln Trp Lys Asp Val Asp Asn Phe Lys Leu
145                 150                 155                 160 
Pro Glu Asp Asp Leu Arg Gly Ile Gln Gln Leu Tyr Gly Thr Pro Asp
                165                 170                 175     
Gly Gln Pro Gln Pro Thr Gln Pro Leu Pro Thr Val Thr Pro Arg Arg
            180                 185                 190         
Pro Gly Arg Pro Asp His Arg Pro Pro Arg Pro Pro Gln Pro Pro Pro
        195                 200                 205             
Pro Gly Gly Lys Pro Glu Arg Pro Pro Lys Pro Gly Pro Pro Val Gln
    210                 215                 220                 
Pro Arg Ala Thr Glu Arg Pro Asp Gln Tyr Gly Pro Asn Ile Cys Asp
225                 230                 235                 240 
Gly Asp Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met Phe Val Phe
                245                 250                 255     
Lys Gly Arg Trp Phe Trp Arg Val Arg His Asn Arg Val Leu Asp Asn
            260                 265                 270         
Tyr Pro Met Pro Ile Gly His Phe Trp Arg Gly Leu Pro Gly Asp Ile
        275                 280                 285             
Ser Ala Ala Tyr Glu Arg Gln Asp Gly Arg Phe Val Phe Phe Lys Gly
    290                 295                 300                 
Asp Arg Tyr Trp Leu Phe Arg Glu Ala Asn Leu Glu Pro Gly Tyr Pro
305                 310                 315                 320 
Gln Pro Leu Thr Ser Tyr Gly Leu Gly Ile Pro Tyr Asp Arg Ile Asp
                325                 330                 335     
Thr Ala Ile Trp Trp Glu Pro Thr Gly His Thr Phe Phe Phe Gln Glu
            340                 345                 350         
Asp Arg Tyr Trp Arg Phe Asn Glu Glu Thr Gln Arg Gly Asp Pro Gly
        355                 360                 365             
Tyr Pro Lys Pro Ile Ser Val Trp Gln Gly Ile Pro Ala Ser Pro Lys
    370                 375                 380                 
Gly Ala Phe Leu Ser Asn Asp Ala Ala Tyr Thr Tyr Phe Tyr Lys Gly
385                 390                 395                 400 
Thr Lys Tyr Trp Lys Phe Asp Asn Glu Arg Leu Arg Met Glu Pro Gly
                405                 410                 415     
Tyr Pro Lys Ser Ile Leu Arg Asp Phe Met Gly Cys Gln Glu His Val
            420                 425                 430         
Glu Pro Gly Pro Arg Trp Pro Asp Val Ala Arg Pro Pro Phe Asn Pro
        435                 440                 445             
His Gly Gly Ala Glu Pro Gly Ala Asp Ser Ala Glu Gly Asp Val Gly
    450                 455                 460                 
Asp Gly Asp Gly Asp Phe Gly Ala Gly Val Asn Lys Asp Gly Gly Ser
465                 470                 475                 480 
Arg Val Val Val Gln Met Glu Glu Val Ala Arg Thr Val Asn Val Val
                485                 490                 495     
Met Val Leu Val Pro Leu Leu Leu Leu Leu Cys Val Leu Gly Leu Thr
            500                 505                 510         
Tyr Ala Leu Val Gln Met Gln Arg Lys Gly Ala Pro Arg Val Leu Leu
        515                 520                 525             
Tyr
    


<210> 139
<211> 6347
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-16

<400> 139
tctttgagcc ggaaccgccg gtgaacttag gcgccacgtt cccggtgact gaccccggag 60
gatggtgaac aggaactact gctgaccctg tcttcgccgc tgcctctcgg gggctgccga 120
gcgcggggcc cctgtctcct ccccttgccc ggctgtgggt gaacctgcag gctccttacc 180
cacccggagg actttttttt gaaaggaaac gagggaggga gggagaggga gagagggaga 240
aaacgaaggg gagctcgtcc atccattgaa gcacagttca ctatgatctt actcacattc 300
agcactggaa gacggttgga tttcgtgcat cattcggggg tgtttttctt gcaaaccttg 360
ctttggattt tatgtgctac agtctgcgga acggagcagt atttcaatgt ggaggtttgg 420
ttacaaaagt acggctacct tccaccgact gaccccagaa tgtcagtgct gcgctctgca 480
gagaccatgc agtctgccct agctgccatg cagcagttct atggcattaa catgacagga 540
aaagtggaca gaaacacaat tgactggatg aagaagcccc gatgcggtgt acctgaccag 600
acaagaggta gctccaaatt tcatattcgt cgaaagcgat atgcattgac aggacagaaa 660
tggcagcaca agcacatcac ttacagtata aagaacgtaa ctccaaaagt aggagaccct 720
gagactcgta aagctattcg ccgtgccttt gatgtgtggc agaatgtaac tcctctgaca 780
tttgaagaag ttccctacag tgaattagaa aatggcaaac gtgatgtgga tataaccatt 840
atttttgcat ctggtttcca tggggacagc tctccctttg atggagaggg aggatttttg 900
gcacatgcct acttccctgg accaggaatt ggaggagata cccattttga ctcagatgag 960
ccatggacac taggaaatcc taatcatgat ggaaatgact tatttcttgt agcagtccat 1020
gaactgggac atgctctggg attggagcat tccaatgacc ccactgccat catggctcca 1080
ttttaccagt acatggaaac agacaacttc aaactaccta atgatgattt acagggcatc 1140
cagaagatat atggtccacc tgacaagatt cctccaccta caagacctct accgacagtg 1200
cccccacacc gctctattcc tccggctgac ccaaggaaaa atgacaggcc aaaacctcct 1260
cggcctccaa ccggcagacc ctcctatccc ggagccaaac ccaacatctg tgatgggaac 1320
tttaacactc tagctattct tcgtcgtgag atgtttgttt tcaaggacca gtggttttgg 1380
cgagtgagaa acaacagggt gatggatgga tacccaatgc aaattactta cttctggcgg 1440
ggcttgcctc ctagtatcga tgcagtttat gaaaatagcg acgggaattt tgtgttcttt 1500
aaaggtaaca aatattgggt gttcaaggat acaactcttc aacctggtta ccctcatgac 1560
ttgataaccc ttggaagtgg aattccccct catggtattg attcagccat ttggtgggag 1620
gacgtcggga aaacctattt cttcaaggga gacagatatt ggagatatag tgaagaaatg 1680
aaaacaatgg accctggcta tcccaagcca atcacagtct ggaaagggat ccctgaatct 1740
cctcagggag catttgtaca caaagaaaat ggctttacgt atttctacaa aggaaaggag 1800
tattggaaat tcaacaacca gatactcaag gtagaacctg gatatccaag atccatcctc 1860
aaggatttta tgggctgtga tggaccaaca gacagagtta aagaaggaca cagcccacca 1920
gatgatgtag acattgtcat caaactggac aacacagcca gcactgtgaa agccatagct 1980
attgtcattc cctgcatctt ggccttatgc ctccttgtat tggtttacac tgtgttccag 2040
ttcaagagga aaggaacacc ccgccacata ctgtactgta aacgctctat gcaagagtgg 2100
gtgtgatgta gggttttttc ttctttcttt cttttgcagg agtttgtggt aacttgagat 2160
tcaagacaag agctgttatg ctgtttccta gctaggagca ggcttgtggc agcctgattc 2220
ggggctgacc tttcaaaccc agagggttgc tggtcctgca catgagtgga aatacactca 2280
tggggaagct tccatgatgc acagtatctg ctgttcttca gtcctttgtc tttctttgtc 2340
attcagttct aggcctttcc tctgcacgct caatgcccag taaaatttca ggattaacta 2400
aagaagagga gaaaaagaag aaaagattct tcttaaaagt ttctaatgtt attttccttc 2460
tgaagtctga gcccatttct ggggggagaa aaaaaaagca aatcagaaaa cccacggttt 2520
ttcttttttt ctttttttct ttttttcttt ttttgcttta aaacaaaggg aaaaaagagt 2580
ttaaacaaaa aacccacaat tgaacttcca ggaaagtgtg aagacccaaa acagctttgt 2640
ctccaaagaa gatagctctc tgactgcttt ggatagtctc ctacgcacca ttttgtcagg 2700
tgggagattt ggaatacaca tgcaggacgt tagactgttg ggacagccat tttccaacaa 2760
ccaaggggcc aaaatatctg caatatagta acagccttaa taatacatcc atttttcgtt 2820
ttatacagct gttctcagct atgtcctcag tgtttcatcg catttatatt catagctatt 2880
ttcaaacacg accttttaat tgtttttgaa gtatttctaa accccttctt tccaccttac 2940
tcctccatca ttgtgataat cttcccaagt tgtattaggc cattgcccca ggccttccat 3000
gggtctgtca ggaatattcg ttacaaagca gagcaagaag cagtatgtct ctgaagtgga 3060
ttacagtggc agttatttta caaggatttg tgacactagt aacatacccg tgtaaccctt 3120
tgagaactat cagaccagct ttcagagtct taggattgtc ggtcttgcga tctgataaat 3180
tatagaactg ggcaatggta aaaacagtca caagttcaag aagttcaggt ttttaaaaca 3240
gatatcctat aatgtcatat aatttttaaa tgatttacaa gactacataa atgtgtttat 3300
aacaaacaga aatgatgtta cttgccaaaa tttttctggc aaataaaaaa ggtattttat 3360
taagattctc ataaatctga aattttattt gaaaaactga taatagccta agtcttcttt 3420
tctttttttt aggcatactg aatttctgtt ttaaaatcca ttgcatgaaa attcaatttg 3480
ccttggtata tgcagttagc attgccattt taaaaatgaa ttaaaacggt gactctgaag 3540
ttgcatgaat atcctccagt gcattaccta ttgcatgtcc accatagttc tcaaagggtt 3600
agtgtggctt ctggcattta gccgtccatt tgatcactga cagagccaag agaccaccaa 3660
agcatttcat tgttgagtgt aatttgtcct aacagcagta ttgtcatttt catgtgacct 3720
gcagagcagg tttgtatcaa tatttttttc ctagagaaaa gtcagcaact gacagacctc 3780
tttattgatt tttaggagct gcttcttgca gtgaaaggct ttacagccac tgggctgtga 3840
acttattaga gatggtcaga atgaatgcac cccatgagtc agacattggc tttgtgtgaa 3900
agccagcttt gaggggatta gcttttgaaa caatgaacag cttgccttga acttgattat 3960
tgatctattg actgtcatta acaacaactt aaacattgtc ttctgtgaaa attttccttg 4020
aagagtcctg ttctatgtct ttgccctttg acctttaact tgcaaactgg cacaaactga 4080
aggaaatctg gtgttgcttc tccattggat tagttgttct ctaaaaccta gtaagcatga 4140
gctgtttcct tagagtggag agagtggtga tggcagatct gcagatggac actttgctct 4200
ttacatgcac actctgaaaa tgccctatag gtagaagtga attttaattt cattttaata 4260
taatttcaag tctaaattca tcattttagt acaaattaca aaaactatag gaaaaaaaaa 4320
acctcaaata cttgaatggc cagtgtggct tttatataaa gcaggaattt tatactagta 4380
aaaatttctt actcatttgc taatacacat ttccagatga tttttaatga gtgtaggtat 4440
acattcttat ttggaaatgg atagtttggc tgccttgaat ttatatttat actcaacgta 4500
gcatgaaaat tagaatgcct tttggttaaa ctacatgttt atgatttggt tggggaaaat 4560
attttataat tgtgggtggc atgctgcaaa gccttgcaga ttgttatttc ttacaacctg 4620
agcgtatata gtatgagcct aagaaaaaag aagagtaaga aaagaagaat ggctttacag 4680
taaaatatca tacaatgcag acaatatttt aagaggatat tggagattat gtacgcaagg 4740
gccaagaaag caagaaatga gaaccagagt cagccctgta gctttacttc agtgcttcca 4800
ttctagatga tgctgatatt ataaagagtt agtcactgct gctaagcatg gaggactata 4860
tacataagct cgtttataca gtgtttgctt gtgggagggt ttaatccttt tagggccttg 4920
atgtcaagaa aaaaataact ggaaactata ttttgctaaa gatagaaatg aggaactgtg 4980
tcattttggg acatgtgcaa atcattgagg aactccatca ccctgcattg aaaattgatt 5040
tttttttcct ctaaaatgag aaagaaactg aataagcaat ctgttgcctc tttactcatt 5100
catcacaata tcctgattcg tcataaggct atcagtatat aagggctaga aaataatcat 5160
agcattaaga aggaaggagt ctatcattat gcttgaattc tggcaaatgt catgaataag 5220
ggttgggtca tatttacttt aatatgagac aagatttatg tgataagcaa aggcatataa 5280
ggctgctctt ttgaacagaa catttcagtt atcaggctgt actattacaa gagataagaa 5340
gacaataagg acaatgtaat cacaaacagt gggattccat ttgtttattg tacaccagct 5400
actttgtggg tatggttcct gactcctctt ctacatgagg tttgggaaaa aagtctcaaa 5460
ccaaatggaa cagtgaaagg gaaagtaatt catctagcac ataagaatag tgattcaaaa 5520
ccaatgcaga ataaatttcc atgggtcaat aacataaggt gtcagttcag tgttactaga 5580
gatatgcaag gcataaaata ttttcatcac cccatcacta ataacatgaa aagctcagac 5640
ataggatttc ccaaattgaa atgaaaacac attcatgcct gcaaaaataa ttctccttct 5700
gcttcatttc tcattacttt atctaatata aacacaaatg taaacaaggt aatggtcttc 5760
atgtaaaatg accatatagt taagaatttt agtaaaatat tgttgttctg tgtattatta 5820
aacaaatgca atgaagtatt aaaatagctg atcagtttga atttcctgta aagcagtaat 5880
tccgcatcag aattgtagat aaggttgtga atttattgac tcatttcaga acagtgtctg 5940
ttgacatggc agtcagagca ggtgaataca gatgctcttt ctgattgcaa aggttataga 6000
gctaaattag acagcattat gtgatactag caaagacaac ttctgttata aatcagaggg 6060
caaggctttt ctgaatcgat gtgataaatt actaagtaat gattaccaaa aataattact 6120
aagtaataaa agatacagac tggtttactg aaataagcaa gtgttacatt taataattac 6180
ctataatctt tttttgttaa cacataagca agtgttacct ttaataatta cctataatct 6240
ttttttgtta acacataatt tggccatttc atatactgtg tacctatttt cattccctct 6300
ctgtgggtca ttaaaaaaca caatgtggtg gataaaaaaa aaaaaaa               6347



<210> 140
<211> 607
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-16 precursor

<400> 140
Met Ile Leu Leu Thr Phe Ser Thr Gly Arg Arg Leu Asp Phe Val His
 1               5                  10                  15      
His Ser Gly Val Phe Phe Leu Gln Thr Leu Leu Trp Ile Leu Cys Ala
            20                  25                  30          
Thr Val Cys Gly Thr Glu Gln Tyr Phe Asn Val Glu Val Trp Leu Gln
        35                  40                  45              
Lys Tyr Gly Tyr Leu Pro Pro Thr Asp Pro Arg Met Ser Val Leu Arg
    50                  55                  60                  
Ser Ala Glu Thr Met Gln Ser Ala Leu Ala Ala Met Gln Gln Phe Tyr
65                  70                  75                  80  
Gly Ile Asn Met Thr Gly Lys Val Asp Arg Asn Thr Ile Asp Trp Met
                85                  90                  95      
Lys Lys Pro Arg Cys Gly Val Pro Asp Gln Thr Arg Gly Ser Ser Lys
            100                 105                 110         
Phe His Ile Arg Arg Lys Arg Tyr Ala Leu Thr Gly Gln Lys Trp Gln
        115                 120                 125             
His Lys His Ile Thr Tyr Ser Ile Lys Asn Val Thr Pro Lys Val Gly
    130                 135                 140                 
Asp Pro Glu Thr Arg Lys Ala Ile Arg Arg Ala Phe Asp Val Trp Gln
145                 150                 155                 160 
Asn Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr Ser Glu Leu Glu
                165                 170                 175     
Asn Gly Lys Arg Asp Val Asp Ile Thr Ile Ile Phe Ala Ser Gly Phe
            180                 185                 190         
His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly Phe Leu Ala His
        195                 200                 205             
Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr His Phe Asp Ser
    210                 215                 220                 
Asp Glu Pro Trp Thr Leu Gly Asn Pro Asn His Asp Gly Asn Asp Leu
225                 230                 235                 240 
Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu Gly Leu Glu His
                245                 250                 255     
Ser Asn Asp Pro Thr Ala Ile Met Ala Pro Phe Tyr Gln Tyr Met Glu
            260                 265                 270         
Thr Asp Asn Phe Lys Leu Pro Asn Asp Asp Leu Gln Gly Ile Gln Lys
        275                 280                 285             
Ile Tyr Gly Pro Pro Asp Lys Ile Pro Pro Pro Thr Arg Pro Leu Pro
    290                 295                 300                 
Thr Val Pro Pro His Arg Ser Ile Pro Pro Ala Asp Pro Arg Lys Asn
305                 310                 315                 320 
Asp Arg Pro Lys Pro Pro Arg Pro Pro Thr Gly Arg Pro Ser Tyr Pro
                325                 330                 335     
Gly Ala Lys Pro Asn Ile Cys Asp Gly Asn Phe Asn Thr Leu Ala Ile
            340                 345                 350         
Leu Arg Arg Glu Met Phe Val Phe Lys Asp Gln Trp Phe Trp Arg Val
        355                 360                 365             
Arg Asn Asn Arg Val Met Asp Gly Tyr Pro Met Gln Ile Thr Tyr Phe
    370                 375                 380                 
Trp Arg Gly Leu Pro Pro Ser Ile Asp Ala Val Tyr Glu Asn Ser Asp
385                 390                 395                 400 
Gly Asn Phe Val Phe Phe Lys Gly Asn Lys Tyr Trp Val Phe Lys Asp
                405                 410                 415     
Thr Thr Leu Gln Pro Gly Tyr Pro His Asp Leu Ile Thr Leu Gly Ser
            420                 425                 430         
Gly Ile Pro Pro His Gly Ile Asp Ser Ala Ile Trp Trp Glu Asp Val
        435                 440                 445             
Gly Lys Thr Tyr Phe Phe Lys Gly Asp Arg Tyr Trp Arg Tyr Ser Glu
    450                 455                 460                 
Glu Met Lys Thr Met Asp Pro Gly Tyr Pro Lys Pro Ile Thr Val Trp
465                 470                 475                 480 
Lys Gly Ile Pro Glu Ser Pro Gln Gly Ala Phe Val His Lys Glu Asn
                485                 490                 495     
Gly Phe Thr Tyr Phe Tyr Lys Gly Lys Glu Tyr Trp Lys Phe Asn Asn
            500                 505                 510         
Gln Ile Leu Lys Val Glu Pro Gly Tyr Pro Arg Ser Ile Leu Lys Asp
        515                 520                 525             
Phe Met Gly Cys Asp Gly Pro Thr Asp Arg Val Lys Glu Gly His Ser
    530                 535                 540                 
Pro Pro Asp Asp Val Asp Ile Val Ile Lys Leu Asp Asn Thr Ala Ser
545                 550                 555                 560 
Thr Val Lys Ala Ile Ala Ile Val Ile Pro Cys Ile Leu Ala Leu Cys
                565                 570                 575     
Leu Leu Val Leu Val Tyr Thr Val Phe Gln Phe Lys Arg Lys Gly Thr
            580                 585                 590         
Pro Arg His Ile Leu Tyr Cys Lys Arg Ser Met Gln Glu Trp Val
        595                 600                 605         


<210> 141
<211> 481
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-16 mature

<400> 141
Tyr Ala Leu Thr Gly Gln Lys Trp Gln His Lys His Ile Thr Tyr Ser
 1               5                  10                  15      
Ile Lys Asn Val Thr Pro Lys Val Gly Asp Pro Glu Thr Arg Lys Ala
            20                  25                  30          
Ile Arg Arg Ala Phe Asp Val Trp Gln Asn Val Thr Pro Leu Thr Phe
        35                  40                  45              
Glu Glu Val Pro Tyr Ser Glu Leu Glu Asn Gly Lys Arg Asp Val Asp
    50                  55                  60                  
Ile Thr Ile Ile Phe Ala Ser Gly Phe His Gly Asp Ser Ser Pro Phe
65                  70                  75                  80  
Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Gly
                85                  90                  95      
Ile Gly Gly Asp Thr His Phe Asp Ser Asp Glu Pro Trp Thr Leu Gly
            100                 105                 110         
Asn Pro Asn His Asp Gly Asn Asp Leu Phe Leu Val Ala Val His Glu
        115                 120                 125             
Leu Gly His Ala Leu Gly Leu Glu His Ser Asn Asp Pro Thr Ala Ile
    130                 135                 140                 
Met Ala Pro Phe Tyr Gln Tyr Met Glu Thr Asp Asn Phe Lys Leu Pro
145                 150                 155                 160 
Asn Asp Asp Leu Gln Gly Ile Gln Lys Ile Tyr Gly Pro Pro Asp Lys
                165                 170                 175     
Ile Pro Pro Pro Thr Arg Pro Leu Pro Thr Val Pro Pro His Arg Ser
            180                 185                 190         
Ile Pro Pro Ala Asp Pro Arg Lys Asn Asp Arg Pro Lys Pro Pro Arg
        195                 200                 205             
Pro Pro Thr Gly Arg Pro Ser Tyr Pro Gly Ala Lys Pro Asn Ile Cys
    210                 215                 220                 
Asp Gly Asn Phe Asn Thr Leu Ala Ile Leu Arg Arg Glu Met Phe Val
225                 230                 235                 240 
Phe Lys Asp Gln Trp Phe Trp Arg Val Arg Asn Asn Arg Val Met Asp
                245                 250                 255     
Gly Tyr Pro Met Gln Ile Thr Tyr Phe Trp Arg Gly Leu Pro Pro Ser
            260                 265                 270         
Ile Asp Ala Val Tyr Glu Asn Ser Asp Gly Asn Phe Val Phe Phe Lys
        275                 280                 285             
Gly Asn Lys Tyr Trp Val Phe Lys Asp Thr Thr Leu Gln Pro Gly Tyr
    290                 295                 300                 
Pro His Asp Leu Ile Thr Leu Gly Ser Gly Ile Pro Pro His Gly Ile
305                 310                 315                 320 
Asp Ser Ala Ile Trp Trp Glu Asp Val Gly Lys Thr Tyr Phe Phe Lys
                325                 330                 335     
Gly Asp Arg Tyr Trp Arg Tyr Ser Glu Glu Met Lys Thr Met Asp Pro
            340                 345                 350         
Gly Tyr Pro Lys Pro Ile Thr Val Trp Lys Gly Ile Pro Glu Ser Pro
        355                 360                 365             
Gln Gly Ala Phe Val His Lys Glu Asn Gly Phe Thr Tyr Phe Tyr Lys
    370                 375                 380                 
Gly Lys Glu Tyr Trp Lys Phe Asn Asn Gln Ile Leu Lys Val Glu Pro
385                 390                 395                 400 
Gly Tyr Pro Arg Ser Ile Leu Lys Asp Phe Met Gly Cys Asp Gly Pro
                405                 410                 415     
Thr Asp Arg Val Lys Glu Gly His Ser Pro Pro Asp Asp Val Asp Ile
            420                 425                 430         
Val Ile Lys Leu Asp Asn Thr Ala Ser Thr Val Lys Ala Ile Ala Ile
        435                 440                 445             
Val Ile Pro Cys Ile Leu Ala Leu Cys Leu Leu Val Leu Val Tyr Thr
    450                 455                 460                 
Val Phe Gln Phe Lys Arg Lys Gly Thr Pro Arg His Ile Leu Tyr Cys
465                 470                 475                 480 
Lys
    


<210> 142
<211> 2438
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-17

<400> 142
ccggcggggg cgccgcggag agcggagggc gccgggctgc ggaacgcgaa gcggagggcg 60
cgggaccctg cacgccgccc gcgggcccat gtgagcgcca tgcggcgccg cgcagcccgg 120
ggacccggcc cgccgccccc agggcccgga ctctcgcggt tgccgctgct gccgctgccg 180
ctgctgctgc tgctggcgct ggggacccgc gggggctgcg ccgcgcccgc acccgcgccg 240
cgcgccgagg acctcagcct gggagtggag tggctaagca ggttcggtta cctgcccccg 300
gctgacccca caacagggca gctgcagacg caagaggagc tgtctaaggc catcacagcc 360
atgcagcagt ttggtggcct ggaggccacc ggcatcctgg acgaggccac cctggccctg 420
atgaaaaccc cacgctgctc cctgccagac ctccctgtcc tgacccaggc tcgcaggaga 480
cgccaggctc cagcccccac caagtggaac aagaggaacc tgtcgtggag ggtccggacg 540
ttcccacggg actcaccact ggggcacgac acggtgcgtg cactcatgta ctacgccctc 600
aaggtctgga gcgacattgc gcccctgaac ttccacgagg tggcgggcag caccgccgac 660
atccagatcg acttctccaa ggccgaccat aacgacggct accccttcga cggccccggc 720
ggcaccgtgg cccacgcctt cttccccggc caccaccaca ccgccgggga cacccacttt 780
gacgatgacg aggcctggac cttccgctcc tcggatgccc acgggatgga cctgtttgca 840
gtggctgtcc acgagtttgg ccacgccatt gggttaagcc atgtggccgc tgcacactcc 900
atcatgcggc cgtactacca gggcccggtg ggtgacccgc tgcgctacgg gctcccctac 960
gaggacaagg tgcgcgtctg gcagctgtac ggtgtgcggg agtctgtgtc tcccacggcg 1020
cagcccgagg agcctcccct gctgccggag cccccagaca accggtccag cgccccgccc 1080
aggaaggacg tgccccacag atgcagcact cactttgacg cggtggccca gatccgcggt 1140
gaagctttct tcttcaaagg caagtacttc tggcggctga cgcgggaccg gcacctggtg 1200
tccctgcagc cggcacagat gcaccgcttc tggcggggcc tgccgctgca cctggacagc 1260
gtggacgccg tgtacgagcg caccagcgac cacaagatcg tcttctttaa aggagacagg 1320
tactgggtgt tcaaggacaa taacgtagag gaaggatacc cgcgccccgt ctccgacttc 1380
agcctcccgc ctggcggcat cgacgctgcc ttctcctggg cccacaatga caggacttat 1440
ttctttaagg accagctgta ctggcgctac gatgaccaca cgaggcacat ggaccccggc 1500
taccccgccc agagccccct gtggaggggt gtccccagca cgctggacga cgccatgcgc 1560
tggtccgacg gtgcctccta cttcttccgt ggccaggagt actggaaagt gctggatggc 1620
gagctggagg tggcacccgg gtacccacag tccacggccc gggactggct ggtgtgtgga 1680

gactcacagg ccgatggatc tgtggctgcg ggcgtggacg cggcagaggg gccccgcgcc 1740
cctccaggac aacatgacca gagccgctcg gaggacggtt acgaggtctg ctcatgcacc 1800
tctggggcat cctctccccc gggggcccca ggcccactgg tggctgccac catgctgctg 1860
ctgctgccgc cactgtcacc aggcgccctg tggacagcgg cccaggccct gacgctatga 1920
cacacagcgc gagcccatga gaggacagag gcggtgggac agcctggcca cagagggcaa 1980
ggactgtgcc ggagtccctg ggggaggtgc tggcgcggga tgaggacggg ccaccctggc 2040
accggaaggc cagcagaggg cacggcccgc cagggctggg caggctcagg tggcaaggac 2100
ggagctgtcc cctagtgagg gactgtgttg actgacgagc cgaggggtgg ccgctccaga 2160
agggtgccca gtcaggccgc accgccgcca gcctcctccg gccctggagg gagcatctcg 2220
ggctgggggc ccacccctct ctgtgccggc gccaccaacc ccacccacac tgctgcctgg 2280
tgctcccgcc ggcccacagg gcctccgtcc ccaggtcccc agtggggcag ccctccccac 2340
agacgagccc cccacatggt gccgcggcac gtcccccctg tgacgcgttc cagaccaaca 2400
tgacctctcc ctgctttgta aaaaaaaaaa aaaaaaaa                         2438

<210> 143
<211> 606
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-17 precursor

<400> 143
Met Arg Arg Arg Ala Ala Arg Gly Pro Gly Pro Pro Pro Pro Gly Pro
 1               5                  10                  15      
Gly Leu Ser Arg Leu Pro Leu Leu Pro Leu Pro Leu Leu Leu Leu Leu
            20                  25                  30          
Ala Leu Gly Thr Arg Gly Gly Cys Ala Ala Pro Ala Pro Ala Pro Arg
        35                  40                  45              
Ala Glu Asp Leu Ser Leu Gly Val Glu Trp Leu Ser Arg Phe Gly Tyr
    50                  55                  60                  
Leu Pro Pro Ala Asp Pro Thr Thr Gly Gln Leu Gln Thr Gln Glu Glu
65                  70                  75                  80  
Leu Ser Lys Ala Ile Thr Ala Met Gln Gln Phe Gly Gly Leu Glu Ala
                85                  90                  95      
Thr Gly Ile Leu Asp Glu Ala Thr Leu Ala Leu Met Lys Thr Pro Arg
            100                 105                 110         
Cys Ser Leu Pro Asp Leu Pro Val Leu Thr Gln Ala Arg Arg Arg Arg
        115                 120                 125             
Gln Ala Pro Ala Pro Thr Lys Trp Asn Lys Arg Asn Leu Ser Trp Arg
    130                 135                 140                 
Val Arg Thr Phe Pro Arg Asp Ser Pro Leu Gly His Asp Thr Val Arg
145                 150                 155                 160 
Ala Leu Met Tyr Tyr Ala Leu Lys Val Trp Ser Asp Ile Ala Pro Leu
                165                 170                 175     
Asn Phe His Glu Val Ala Gly Ser Thr Ala Asp Ile Gln Ile Asp Phe
            180                 185                 190         
Ser Lys Ala Asp His Asn Asp Gly Tyr Pro Phe Asp Gly Pro Gly Gly
        195                 200                 205             
Thr Val Ala His Ala Phe Phe Pro Gly His His His Thr Ala Gly Asp
    210                 215                 220                 
Thr His Phe Asp Asp Asp Glu Ala Trp Thr Phe Arg Ser Ser Asp Ala
225                 230                 235                 240 
His Gly Met Asp Leu Phe Ala Val Ala Val His Glu Phe Gly His Ala
                245                 250                 255     
Ile Gly Leu Ser His Val Ala Ala Ala His Ser Ile Met Arg Pro Tyr
            260                 265                 270         
Tyr Gln Gly Pro Val Gly Asp Pro Leu Arg Tyr Gly Leu Pro Tyr Glu
        275                 280                 285             
Asp Lys Val Arg Val Trp Gln Leu Tyr Gly Val Arg Glu Ser Val Ser
    290                 295                 300                 
Pro Thr Ala Gln Pro Glu Glu Pro Pro Leu Leu Pro Glu Pro Pro Asp
305                 310                 315                 320 
Asn Arg Ser Ser Ala Pro Pro Arg Lys Asp Val Pro His Arg Cys Ser
                325                 330                 335     
Thr His Phe Asp Ala Val Ala Gln Ile Arg Gly Glu Ala Phe Phe Phe
            340                 345                 350         
Lys Gly Lys Tyr Phe Trp Arg Leu Thr Arg Asp Arg His Leu Val Ser
        355                 360                 365             
Leu Gln Pro Ala Gln Met His Arg Phe Trp Arg Gly Leu Pro Leu His
    370                 375                 380                 
Leu Asp Ser Val Asp Ala Val Tyr Glu Arg Thr Ser Asp His Lys Ile
385                 390                 395                 400 
Val Phe Phe Lys Gly Asp Arg Tyr Trp Val Phe Lys Asp Asn Asn Val
                405                 410                 415     
Glu Glu Gly Tyr Pro Arg Pro Val Ser Asp Phe Ser Leu Pro Pro Gly
            420                 425                 430         
Gly Ile Asp Ala Ala Phe Ser Trp Ala His Asn Asp Arg Thr Tyr Phe
        435                 440                 445             
Phe Lys Asp Gln Leu Tyr Trp Arg Tyr Asp Asp His Thr Arg His Met
    450                 455                 460                 
Asp Pro Gly Tyr Pro Ala Gln Ser Pro Leu Trp Arg Gly Val Pro Ser
465                 470                 475                 480 
Thr Leu Asp Asp Ala Met Arg Trp Ser Asp Gly Ala Ser Tyr Phe Phe
                485                 490                 495     
Arg Gly Gln Glu Tyr Trp Lys Val Leu Asp Gly Glu Leu Glu Val Ala
            500                 505                 510         
Pro Gly Tyr Pro Gln Ser Thr Ala Arg Asp Trp Leu Val Cys Gly Asp
        515                 520                 525             
Ser Gln Ala Asp Gly Ser Val Ala Ala Gly Val Asp Ala Ala Glu Gly
    530                 535                 540                 
Pro Arg Ala Pro Pro Gly Gln His Asp Gln Ser Arg Ser Glu Asp Gly
545                 550                 555                 560 
Tyr Glu Val Cys Ser Cys Thr Ser Gly Ala Ser Ser Pro Pro Gly Ala
                565                 570                 575     
Pro Gly Pro Leu Val Ala Ala Thr Met Leu Leu Leu Leu Pro Pro Leu
            580                 585                 590         
Ser Pro Gly Ala Leu Trp Thr Ala Ala Gln Ala Leu Thr Leu
        595                 600                 605     


<210> 144
<211> 478
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-17mature

<400> 144
Gln Ala Pro Ala Pro Thr Lys Trp Asn Lys Arg Asn Leu Ser Trp Arg
 1               5                  10                  15      
Val Arg Thr Phe Pro Arg Asp Ser Pro Leu Gly His Asp Thr Val Arg
            20                  25                  30          
Ala Leu Met Tyr Tyr Ala Leu Lys Val Trp Ser Asp Ile Ala Pro Leu
        35                  40                  45              
Asn Phe His Glu Val Ala Gly Ser Thr Ala Asp Ile Gln Ile Asp Phe
    50                  55                  60                  
Ser Lys Ala Asp His Asn Asp Gly Tyr Pro Phe Asp Gly Pro Gly Gly
65                  70                  75                  80  
Thr Val Ala His Ala Phe Phe Pro Gly His His His Thr Ala Gly Asp
                85                  90                  95      
Thr His Phe Asp Asp Asp Glu Ala Trp Thr Phe Arg Ser Ser Asp Ala
            100                 105                 110         
His Gly Met Asp Leu Phe Ala Val Ala Val His Glu Phe Gly His Ala
        115                 120                 125             
Ile Gly Leu Ser His Val Ala Ala Ala His Ser Ile Met Arg Pro Tyr
    130                 135                 140                 
Tyr Gln Gly Pro Val Gly Asp Pro Leu Arg Tyr Gly Leu Pro Tyr Glu
145                 150                 155                 160 
Asp Lys Val Arg Val Trp Gln Leu Tyr Gly Val Arg Glu Ser Val Ser
                165                 170                 175     
Pro Thr Ala Gln Pro Glu Glu Pro Pro Leu Leu Pro Glu Pro Pro Asp
            180                 185                 190         
Asn Arg Ser Ser Ala Pro Pro Arg Lys Asp Val Pro His Arg Cys Ser
        195                 200                 205             
Thr His Phe Asp Ala Val Ala Gln Ile Arg Gly Glu Ala Phe Phe Phe
    210                 215                 220                 
Lys Gly Lys Tyr Phe Trp Arg Leu Thr Arg Asp Arg His Leu Val Ser
225                 230                 235                 240 
Leu Gln Pro Ala Gln Met His Arg Phe Trp Arg Gly Leu Pro Leu His
                245                 250                 255     
Leu Asp Ser Val Asp Ala Val Tyr Glu Arg Thr Ser Asp His Lys Ile
            260                 265                 270         
Val Phe Phe Lys Gly Asp Arg Tyr Trp Val Phe Lys Asp Asn Asn Val
        275                 280                 285             
Glu Glu Gly Tyr Pro Arg Pro Val Ser Asp Phe Ser Leu Pro Pro Gly
    290                 295                 300                 
Gly Ile Asp Ala Ala Phe Ser Trp Ala His Asn Asp Arg Thr Tyr Phe
305                 310                 315                 320 
Phe Lys Asp Gln Leu Tyr Trp Arg Tyr Asp Asp His Thr Arg His Met
                325                 330                 335     
Asp Pro Gly Tyr Pro Ala Gln Ser Pro Leu Trp Arg Gly Val Pro Ser
            340                 345                 350         
Thr Leu Asp Asp Ala Met Arg Trp Ser Asp Gly Ala Ser Tyr Phe Phe
        355                 360                 365             
Arg Gly Gln Glu Tyr Trp Lys Val Leu Asp Gly Glu Leu Glu Val Ala
    370                 375                 380                 
Pro Gly Tyr Pro Gln Ser Thr Ala Arg Asp Trp Leu Val Cys Gly Asp
385                 390                 395                 400 
Ser Gln Ala Asp Gly Ser Val Ala Ala Gly Val Asp Ala Ala Glu Gly
                405                 410                 415     
Pro Arg Ala Pro Pro Gly Gln His Asp Gln Ser Arg Ser Glu Asp Gly
            420                 425                 430         
Tyr Glu Val Cys Ser Cys Thr Ser Gly Ala Ser Ser Pro Pro Gly Ala
        435                 440                 445             
Pro Gly Pro Leu Val Ala Ala Thr Met Leu Leu Leu Leu Pro Pro Leu
    450                 455                 460                 
Ser Pro Gly Ala Leu Trp Thr Ala Ala Gln Ala Leu Thr Leu
465                 470                 475             


<210> 145
<211> 3262
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-19

<400> 145
ggctggagag taaaaagaac tgggggtaag agcccctctg cctagcactg ctcccccaag 60
gctcccagaa atctcaggtc agaggcacgg acagcctctg gagctctcgt ctggtgggac 120
catgaactgc cagcagctgt ggctgggctt cctactcccc atgacagtct caggccgggt 180
cctggggctt gcagaggtgg cgcccgtgga ctacctgtca caatatgggt acctacagaa 240
gcctctagaa ggatctaata acttcaagcc agaagatatc accgaggctc tgagagcttt 300
tcaggaagca tctgaacttc cagtctcagg tcagctggat gatgccacaa gggcccgcat 360
gaggcagcct cgttgtggcc tagaggatcc cttcaaccag aagaccctta aatacctgtt 420
gctgggccgc tggagaaaga agcacctgac tttccgcatc ttgaacctgc cctccaccct 480
tccaccccac acagcccggg cagccctgcg tcaagccttc caggactgga gcaatgtggc 540
tcccttgacc ttccaagagg tgcaggctgg tgcggctgac atccgcctct ccttccatgg 600
ccgccaaagc tcgtactgtt ccaatacttt tgatgggcct gggagagtcc tggcccatgc 660
cgacatccca gagctgggca gtgtgcactt cgacgaagac gagttctgga ctgaggggac 720
ctaccgtggg gtgaacctgc gcatcattgc agcccatgaa gtgggccatg ctctggggct 780
tgggcactcc cgatattccc aggccctcat ggccccagtc tacgagggct accggcccca 840
ctttaagctg cacccagatg atgtggcagg gatccaggct ctctatggca agaagagtcc 900
agtgataagg gatgaggaag aagaagagac agagctgccc actgtgcccc cagtgcccac 960
agaacccagt cccatgccag acccttgcag tagtgaactg gatgccatga tgctggggcc 1020
ccgtgggaag acctatgctt tcaaggggga ctatgtgtgg actgtatcag attcaggacc 1080
gggccccttg ttccgagtgt ctgccctttg ggaggggctc cccggaaacc tggatgctgc 1140
tgtctactcg cctcgaacac aatggattca cttctttaag ggagacaagg tgtggcgcta 1200
cattaatttc aagatgtctc ctggcttccc caagaagctg aatagggtag aacctaacct 1260
ggatgcagct ctctattggc ctctcaacca aaaggtgttc ctctttaagg gctccgggta 1320
ctggcagtgg gacgagctag cccgaactga cttcagcagc taccccaaac caatcaaggg 1380
tttgtttacg ggagtgccaa accagccctc ggctgctatg agttggcaag atggccgagt 1440
ctacttcttc aagggcaaag tctactggcg cctcaaccag cagcttcgag tagagaaagg 1500
ctatcccaga aatatttccc acaactggat gcactgtcgt ccccggacta tagacactac 1560
cccatcaggt gggaatacca ctccctcagg tacgggcata accttggata ccactctctc 1620
agccacagaa accacgtttg aatactgact gctcacccac agacacaatc ttggacatta 1680
acccctgagg ctccaccacc caccctttca tttccccccc agaagcctaa ggcctaatag 1740
ctgaatgaaa tacctgtctg ctcagtagaa ccttgcaggt gctgtagcag gcgcaagacc 1800
gtagatctca ggcctctaac acttccaact ccagccacca ctttcctgtg cattttcact 1860
cctgagaagt gctcccctaa ctcagatccc ctaacttaga tttggccccc aactccattt 1920
cctgtctgtc ttagacagcc cttccaactg tgtcatctct tctctggagg tcaatggtgg 1980
agggagatgc ctgggtcctg ttcttcctac ataaaatgca agaaaacagc atggccagta 2040
aactgagcaa gggccttgga atccttgaga atcacattta tgtgcttatg attacgggca 2100
agctaattaa ccttgttgaa tctcagattc cccatttgca acattaggtt aagaccagta 2160
ctgcaggatt gttgcactaa atgaaatact gtatgtgaag tgcctggcac agtgtctggt 2220
acatttgtgt ttaataaaag ctaactccat gttcataaga gaggactgaa cagctcttcc 2280
tctagctgtc tggctgtata actcttacag tagtctgtat aataagggca tctctattag 2340
atctttaggg gacagaggat ttgtcaagat ggttagctct ttgttttggg gtgcagagaa 2400
agaaaagagc agcaacagca gaggctggac tccctggttc agtatttaat gccattttat 2460
tcacatgctc ccatgttctc cctccctccc attgtagcct tgctgcccag gggagggata 2520
tgtcttcctt tatgcatctg ggaaaccagg aacagaccct gcgcaggaga gtcagagggg 2580
gaagagttag aatgggtcag tggctggaac aaagttctgg ttaaggagga aattagtgcc 2640
acccacggtg agaagcagag aaggcacttg catcctatgc agccctgaag accaggctcc 2700
tttgggcaaa aggcaagact ctggcaggtg ggtcaatgct ctctccttgg agcaagaagc 2760
cagcttttgg ggaaggcagg tcctgaggca ggcactgccc tgtggtcttc cccaggttga 2820
ggagagaagt ggaagcccca tggaagacag tgctcccagc tgaggtagga ggcggaggtg 2880
ggggtggggg tagtttaagc ctatggggcc cagggggaaa ggccaaacag aaacccaact 2940
accccctaat gaagggcctg gaggttgggg tatcttggag ctcctcagag cccttcttcc 3000
catcaaaaag gtatcaaatg ccttggaagc tccctgatcc tacaaaacaa aaaaatgctt 3060
atttttacca ctgtgaggca agctgaggtg aacatttaaa aggctatttc aagacgaggt 3120
gcggtggcta taatcctagc actttgggag gctgaagcag gaggatcact tgagcccagg 3180
agttcaagac cagcttgggc aacataggga gaccctgtct ctgcaaaaaa ataaaaacga 3240
atacataaaa attaaaaaaa aa                                          3262

<210> 146
<211> 508
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-19 precursor

<400> 146
Met Asn Cys Gln Gln Leu Trp Leu Gly Phe Leu Leu Pro Met Thr Val
 1               5                  10                  15      
Ser Gly Arg Val Leu Gly Leu Ala Glu Val Ala Pro Val Asp Tyr Leu
            20                  25                  30          
Ser Gln Tyr Gly Tyr Leu Gln Lys Pro Leu Glu Gly Ser Asn Asn Phe
        35                  40                  45              
Lys Pro Glu Asp Ile Thr Glu Ala Leu Arg Ala Phe Gln Glu Ala Ser
    50                  55                  60                  
Glu Leu Pro Val Ser Gly Gln Leu Asp Asp Ala Thr Arg Ala Arg Met
65                  70                  75                  80  
Arg Gln Pro Arg Cys Gly Leu Glu Asp Pro Phe Asn Gln Lys Thr Leu
                85                  90                  95      
Lys Tyr Leu Leu Leu Gly Arg Trp Arg Lys Lys His Leu Thr Phe Arg
            100                 105                 110         
Ile Leu Asn Leu Pro Ser Thr Leu Pro Pro His Thr Ala Arg Ala Ala
        115                 120                 125             
Leu Arg Gln Ala Phe Gln Asp Trp Ser Asn Val Ala Pro Leu Thr Phe
    130                 135                 140                 
Gln Glu Val Gln Ala Gly Ala Ala Asp Ile Arg Leu Ser Phe His Gly
145                 150                 155                 160 
Arg Gln Ser Ser Tyr Cys Ser Asn Thr Phe Asp Gly Pro Gly Arg Val
                165                 170                 175     
Leu Ala His Ala Asp Ile Pro Glu Leu Gly Ser Val His Phe Asp Glu
            180                 185                 190         
Asp Glu Phe Trp Thr Glu Gly Thr Tyr Arg Gly Val Asn Leu Arg Ile
        195                 200                 205             
Ile Ala Ala His Glu Val Gly His Ala Leu Gly Leu Gly His Ser Arg
    210                 215                 220                 
Tyr Ser Gln Ala Leu Met Ala Pro Val Tyr Glu Gly Tyr Arg Pro His
225                 230                 235                 240 
Phe Lys Leu His Pro Asp Asp Val Ala Gly Ile Gln Ala Leu Tyr Gly
                245                 250                 255     
Lys Lys Ser Pro Val Ile Arg Asp Glu Glu Glu Glu Glu Thr Glu Leu
            260                 265                 270         
Pro Thr Val Pro Pro Val Pro Thr Glu Pro Ser Pro Met Pro Asp Pro
        275                 280                 285             
Cys Ser Ser Glu Leu Asp Ala Met Met Leu Gly Pro Arg Gly Lys Thr
    290                 295                 300                 
Tyr Ala Phe Lys Gly Asp Tyr Val Trp Thr Val Ser Asp Ser Gly Pro
305                 310                 315                 320 
Gly Pro Leu Phe Arg Val Ser Ala Leu Trp Glu Gly Leu Pro Gly Asn
                325                 330                 335     
Leu Asp Ala Ala Val Tyr Ser Pro Arg Thr Gln Trp Ile His Phe Phe
            340                 345                 350         
Lys Gly Asp Lys Val Trp Arg Tyr Ile Asn Phe Lys Met Ser Pro Gly
        355                 360                 365             
Phe Pro Lys Lys Leu Asn Arg Val Glu Pro Asn Leu Asp Ala Ala Leu
    370                 375                 380                 
Tyr Trp Pro Leu Asn Gln Lys Val Phe Leu Phe Lys Gly Ser Gly Tyr
385                 390                 395                 400 
Trp Gln Trp Asp Glu Leu Ala Arg Thr Asp Phe Ser Ser Tyr Pro Lys
                405                 410                 415     
Pro Ile Lys Gly Leu Phe Thr Gly Val Pro Asn Gln Pro Ser Ala Ala
            420                 425                 430         
Met Ser Trp Gln Asp Gly Arg Val Tyr Phe Phe Lys Gly Lys Val Tyr
        435                 440                 445             
Trp Arg Leu Asn Gln Gln Leu Arg Val Glu Lys Gly Tyr Pro Arg Asn
    450                 455                 460                 
Ile Ser His Asn Trp Met His Cys Arg Pro Arg Thr Ile Asp Thr Thr
465                 470                 475                 480 
Pro Ser Gly Gly Asn Thr Thr Pro Ser Gly Thr Gly Ile Thr Leu Asp
                485                 490                 495     
Thr Thr Leu Ser Ala Thr Glu Thr Thr Phe Glu Tyr
            500                 505             


<210> 147
<211> 411
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-19 mature

<400> 147
Tyr Leu Leu Leu Gly Arg Trp Arg Lys Lys His Leu Thr Phe Arg Ile
 1               5                  10                  15      
Leu Asn Leu Pro Ser Thr Leu Pro Pro His Thr Ala Arg Ala Ala Leu
            20                  25                  30          
Arg Gln Ala Phe Gln Asp Trp Ser Asn Val Ala Pro Leu Thr Phe Gln
        35                  40                  45              
Glu Val Gln Ala Gly Ala Ala Asp Ile Arg Leu Ser Phe His Gly Arg
    50                  55                  60                  
Gln Ser Ser Tyr Cys Ser Asn Thr Phe Asp Gly Pro Gly Arg Val Leu
65                  70                  75                  80  
Ala His Ala Asp Ile Pro Glu Leu Gly Ser Val His Phe Asp Glu Asp
                85                  90                  95      
Glu Phe Trp Thr Glu Gly Thr Tyr Arg Gly Val Asn Leu Arg Ile Ile
            100                 105                 110         
Ala Ala His Glu Val Gly His Ala Leu Gly Leu Gly His Ser Arg Tyr
        115                 120                 125             
Ser Gln Ala Leu Met Ala Pro Val Tyr Glu Gly Tyr Arg Pro His Phe
    130                 135                 140                 
Lys Leu His Pro Asp Asp Val Ala Gly Ile Gln Ala Leu Tyr Gly Lys
145                 150                 155                 160 
Lys Ser Pro Val Ile Arg Asp Glu Glu Glu Glu Glu Thr Glu Leu Pro
                165                 170                 175     
Thr Val Pro Pro Val Pro Thr Glu Pro Ser Pro Met Pro Asp Pro Cys
            180                 185                 190         
Ser Ser Glu Leu Asp Ala Met Met Leu Gly Pro Arg Gly Lys Thr Tyr
        195                 200                 205             
Ala Phe Lys Gly Asp Tyr Val Trp Thr Val Ser Asp Ser Gly Pro Gly
    210                 215                 220                 
Pro Leu Phe Arg Val Ser Ala Leu Trp Glu Gly Leu Pro Gly Asn Leu
225                 230                 235                 240 
Asp Ala Ala Val Tyr Ser Pro Arg Thr Gln Trp Ile His Phe Phe Lys
                245                 250                 255     
Gly Asp Lys Val Trp Arg Tyr Ile Asn Phe Lys Met Ser Pro Gly Phe
            260                 265                 270         
Pro Lys Lys Leu Asn Arg Val Glu Pro Asn Leu Asp Ala Ala Leu Tyr
        275                 280                 285             
Trp Pro Leu Asn Gln Lys Val Phe Leu Phe Lys Gly Ser Gly Tyr Trp
    290                 295                 300                 
Gln Trp Asp Glu Leu Ala Arg Thr Asp Phe Ser Ser Tyr Pro Lys Pro
305                 310                 315                 320 
Ile Lys Gly Leu Phe Thr Gly Val Pro Asn Gln Pro Ser Ala Ala Met
                325                 330                 335     
Ser Trp Gln Asp Gly Arg Val Tyr Phe Phe Lys Gly Lys Val Tyr Trp
            340                 345                 350         
Arg Leu Asn Gln Gln Leu Arg Val Glu Lys Gly Tyr Pro Arg Asn Ile
        355                 360                 365             
Ser His Asn Trp Met His Cys Arg Pro Arg Thr Ile Asp Thr Thr Pro
    370                 375                 380                 
Ser Gly Gly Asn Thr Thr Pro Ser Gly Thr Gly Ile Thr Leu Asp Thr
385                 390                 395                 400 
Thr Leu Ser Ala Thr Glu Thr Thr Phe Glu Tyr
                405                 410     


<210> 148
<211> 1674
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-20

<400> 148
ctactgtgag gggatgaagg tgctccctgc atctggcctt gctgtcttcc tcatcatggc 60
tttgaagttt tccactgcag ccccctccct agttgcagcc tcccccagga cctggaggaa 120
caactaccgc ctcgcacagg cgtatcttga caaatattac acaaataaag aaggacacca 180
gattggtgag atggttgcaa gaggaagcaa ttccatgata aggaagatta aggagctaca 240
agcgttcttt ggcctccaag tcaccgggaa gttagaccag accacaatga acgtgatcaa 300
gaagcctcgc tgtggagttc ctgatgtggc caattatcgc ctcttccctg gtgaacccaa 360
atggaaaaaa aatactttga catacagaat atctaaatac acaccttcca tgagttctgt 420
cgaggtggac aaagcagtgg agatggcctt gcaggcctgg agtagcgccg tccctctgag 480
ctttgtcaga ataaactcag gagaagcgga tattatgata tcttttgaaa atggagatca 540
cggggattcc tatccattcg atgggcctcg ggggactcta gcccatgcat ttgctcctgg 600
agaaggcctg ggaggagata cacatttcga caatcctgag aagtggacta tgggaacgaa 660
tggttttaat ttgtttaccg ttgctgctca tgaatttggc catgccctgg gcctggccca 720
ttccacagac ccatcagcac tgatgtaccc aacttataag tacaagaatc cctatggatt 780
ccacctcccc aaagatgatg tgaaagggat ccaggcatta tacggacctc ggaaagtatt 840
cctggggaag cccactctgc cccatgcccc ccatcacaag ccatccatcc ctgacctctg 900
tgactccagc tcatcctttg acgctgtgac aatgctgggg aaggagctcc tgctcttcaa 960
ggaccggatt ttctggagac ggcaggttca cttgcggaca ggaattcggc ccagcactat 1020
taccagctcc ttcccccagc tcatgtccaa tgtggatgca gcttacgaag tggctgagag 1080
gggcactgct tacttcttca aaggtcccca ctactggata acaagaggat tccaaatgca 1140
aggtcctcct cggactattt atgactttgg atttccaagg cacgtgcagc aaatagatgc 1200
tgctgtctac ctcagggagc cacagaagac ccttttcttt gtgggagatg aatactacag 1260
ctacgacgaa aggaaaagga aaatggaaaa agactatcca aagaatactg aagaagaatt 1320
ttcaggagta aatggccaaa tcgatgctgc tgtagaatta aatggctaca tttacttctt 1380
ttcaggacca aaaacataca agtatgacac agagaaggaa gatgtggtta gtgtggtgaa 1440
atctagttcc tggattggtt gctaaataga aaagcctagt cttctcaagc aatgaggatg 1500
actacaagca gcctctaact ggatcttaag gactaaagca gaatgtagga gagggattct 1560
tccaaaggcc ttcaaatcaa attagaattc actgagaata ataatacttc caattttttt 1620
catagttgta taatcagaat ttcaatccac attagaaaag tttttatatg ggca       1674

<210> 149
<211> 483
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-20 precursor

<400> 149
Met Lys Val Leu Pro Ala Ser Gly Leu Ala Val Phe Leu Ile Met Ala
 1               5                  10                  15      
Leu Lys Phe Ser Thr Ala Ala Pro Ser Leu Val Ala Ala Ser Pro Arg
            20                  25                  30          
Thr Trp Arg Asn Asn Tyr Arg Leu Ala Gln Ala Tyr Leu Asp Lys Tyr
        35                  40                  45              
Tyr Thr Asn Lys Glu Gly His Gln Ile Gly Glu Met Val Ala Arg Gly
    50                  55                  60                  
Ser Asn Ser Met Ile Arg Lys Ile Lys Glu Leu Gln Ala Phe Phe Gly
65                  70                  75                  80  
Leu Gln Val Thr Gly Lys Leu Asp Gln Thr Thr Met Asn Val Ile Lys
                85                  90                  95      
Lys Pro Arg Cys Gly Val Pro Asp Val Ala Asn Tyr Arg Leu Phe Pro
            100                 105                 110         
Gly Glu Pro Lys Trp Lys Lys Asn Thr Leu Thr Tyr Arg Ile Ser Lys
        115                 120                 125             
Tyr Thr Pro Ser Met Ser Ser Val Glu Val Asp Lys Ala Val Glu Met
    130                 135                 140                 
Ala Leu Gln Ala Trp Ser Ser Ala Val Pro Leu Ser Phe Val Arg Ile
145                 150                 155                 160 
Asn Ser Gly Glu Ala Asp Ile Met Ile Ser Phe Glu Asn Gly Asp His
                165                 170                 175     
Gly Asp Ser Tyr Pro Phe Asp Gly Pro Arg Gly Thr Leu Ala His Ala
            180                 185                 190         
Phe Ala Pro Gly Glu Gly Leu Gly Gly Asp Thr His Phe Asp Asn Pro
        195                 200                 205             
Glu Lys Trp Thr Met Gly Thr Asn Gly Phe Asn Leu Phe Thr Val Ala
    210                 215                 220                 
Ala His Glu Phe Gly His Ala Leu Gly Leu Ala His Ser Thr Asp Pro
225                 230                 235                 240 
Ser Ala Leu Met Tyr Pro Thr Tyr Lys Tyr Lys Asn Pro Tyr Gly Phe
                245                 250                 255     
His Leu Pro Lys Asp Asp Val Lys Gly Ile Gln Ala Leu Tyr Gly Pro
            260                 265                 270         
Arg Lys Val Phe Leu Gly Lys Pro Thr Leu Pro His Ala Pro His His
        275                 280                 285             
Lys Pro Ser Ile Pro Asp Leu Cys Asp Ser Ser Ser Ser Phe Asp Ala
    290                 295                 300                 
Val Thr Met Leu Gly Lys Glu Leu Leu Leu Phe Lys Asp Arg Ile Phe
305                 310                 315                 320 
Trp Arg Arg Gln Val His Leu Arg Thr Gly Ile Arg Pro Ser Thr Ile
                325                 330                 335     
Thr Ser Ser Phe Pro Gln Leu Met Ser Asn Val Asp Ala Ala Tyr Glu
            340                 345                 350         
Val Ala Glu Arg Gly Thr Ala Tyr Phe Phe Lys Gly Pro His Tyr Trp
        355                 360                 365             
Ile Thr Arg Gly Phe Gln Met Gln Gly Pro Pro Arg Thr Ile Tyr Asp
    370                 375                 380                 
Phe Gly Phe Pro Arg His Val Gln Gln Ile Asp Ala Ala Val Tyr Leu
385                 390                 395                 400 
Arg Glu Pro Gln Lys Thr Leu Phe Phe Val Gly Asp Glu Tyr Tyr Ser
                405                 410                 415     
Tyr Asp Glu Arg Lys Arg Lys Met Glu Lys Asp Tyr Pro Lys Asn Thr
            420                 425                 430         
Glu Glu Glu Phe Ser Gly Val Asn Gly Gln Ile Asp Ala Ala Val Glu
        435                 440                 445             
Leu Asn Gly Tyr Ile Tyr Phe Phe Ser Gly Pro Lys Thr Tyr Lys Tyr
    450                 455                 460                 
Asp Thr Glu Lys Glu Asp Val Val Ser Val Val Lys Ser Ser Ser Trp
465                 470                 475                 480 
Ile Gly Cys
            


<210> 150
<211> 373
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-20 mature

<400> 150
Tyr Arg Leu Phe Pro Gly Glu Pro Lys Trp Lys Lys Asn Thr Leu Thr
 1               5                  10                  15      
Tyr Arg Ile Ser Lys Tyr Thr Pro Ser Met Ser Ser Val Glu Val Asp
            20                  25                  30          
Lys Ala Val Glu Met Ala Leu Gln Ala Trp Ser Ser Ala Val Pro Leu
        35                  40                  45              
Ser Phe Val Arg Ile Asn Ser Gly Glu Ala Asp Ile Met Ile Ser Phe
    50                  55                  60                  
Glu Asn Gly Asp His Gly Asp Ser Tyr Pro Phe Asp Gly Pro Arg Gly
65                  70                  75                  80  
Thr Leu Ala His Ala Phe Ala Pro Gly Glu Gly Leu Gly Gly Asp Thr
                85                  90                  95      
His Phe Asp Asn Ala Glu Lys Trp Thr Met Gly Thr Asn Gly Phe Asn
            100                 105                 110         
Leu Phe Thr Val Ala Ala His Glu Phe Gly His Ala Leu Gly Leu Ala
        115                 120                 125             
His Ser Thr Asp Pro Ser Ala Leu Met Tyr Pro Thr Tyr Lys Tyr Lys
    130                 135                 140                 
Asn Pro Tyr Gly Phe His Leu Pro Lys Asp Asp Val Lys Gly Ile Gln
145                 150                 155                 160 
Ala Leu Tyr Gly Pro Arg Lys Val Phe Leu Gly Lys Pro Thr Leu Pro
                165                 170                 175     
His Ala Pro His His Lys Pro Ser Ile Pro Asp Leu Cys Asp Ser Ser
            180                 185                 190         
Ser Ser Phe Asp Ala Val Thr Met Leu Gly Lys Glu Leu Leu Leu Phe
        195                 200                 205             
Lys Asp Arg Ile Phe Trp Arg Arg Gln Val His Leu Arg Thr Gly Ile
    210                 215                 220                 
Arg Pro Ser Thr Ile Thr Ser Ser Phe Pro Gln Leu Met Ser Asn Val
225                 230                 235                 240 
Asp Ala Ala Tyr Glu Val Ala Glu Arg Gly Thr Ala Tyr Phe Phe Lys
                245                 250                 255     
Gly Pro His Tyr Trp Ile Thr Arg Gly Phe Gln Met Gln Gly Pro Pro
            260                 265                 270         
Arg Thr Ile Tyr Asp Phe Gly Phe Pro Arg His Val Gln Gln Ile Asp
        275                 280                 285             
Ala Ala Val Tyr Leu Arg Glu Pro Gln Lys Thr Leu Phe Phe Val Gly
    290                 295                 300                 
Asp Glu Tyr Tyr Ser Tyr Asp Glu Arg Lys Arg Lys Met Glu Lys Asp
305                 310                 315                 320 
Tyr Pro Lys Asn Thr Glu Glu Glu Phe Ser Gly Val Asn Gly Gln Ile

                325                 330                 335     
Asp Ala Ala Val Glu Leu Asn Gly Tyr Ile Tyr Phe Phe Ser Gly Pro
            340                 345                 350         
Lys Thr Tyr Lys Tyr Asp Thr Glu Lys Glu Asp Val Val Ser Val Val
        355                 360                 365             
Lys Ser Ser Ser Trp
    370             


<210> 151
<211> 3127
<212> DNA
<213> Xenopus laevis

<220> 
<223> XMMP

<400> 151
tcgtggagca ctacagaata tgccgcacag agtcagcaga acggcagcag atgcatcagc 60
atcatatgag gccaccatgc cttctatcaa gcttctggtt tggtgctgct tgtgtgtgat 120
atcccccagg ctgtgccatt ctgagaagct cttccacagt cgggatcggt cagaccttca 180
gccctcagca attgaacagg cagaactggt caaggatatg ctctctgccc agcaattcct 240
ggcaaaatat gggtggacac aaccagttat ttgggatcca tcaagtacca atgaaaacga 300
acctctaaaa gatttcagtc tgatgcaaga gggagtttgt aacccaaggc aagaagtggc 360
tgagccaaca aaaagccccc aattcattga cgcgctcaaa aagtttcaga agctaaacaa 420
cttgccagtg acaggaaccc ttgatgatgc caccatcaac gccatgaaca agccacggtg 480
cggcgtgcca gacaaccaaa tggcaaagaa agagacggag aaaccgacag cagcacagtc 540
acttgaaaac aagactaagg attctgagaa tgttactcaa caaaacccag acccccccaa 600
gattcggagg aagaggttct tagatatgtt aatgtactca aacaagtaca gggaagaaca 660
ggaggcgctt cagaaatcca caggcaaagt cttcaccaaa aagctgctga aatggagaat 720
gattggagaa ggctacagca atcagctttc catcaacgag caaagatatg tcttcaggct 780
ggctttccgc atgtggagtg aagtcatgcc actggacttt gaagaagata acacctcccc 840
tctatcccaa attgatatca aacttggatt cggacgaggt cgccatttag gctgtagccg 900
ggcattcgat ggctctgggc aggagttcgc ccacgcttgg tttctggggg acattcactt 960
tgacgacgat gaacatttta ctgctcccag tagtgagcat gggattagtc tgctgaaggt 1020
ggcagcccat gaaattggcc atgttcttgg attatctcac atccacaggg tgggatcaat 1080
aatgcagccc aattacattc cgcaggactc tggctttgag ctggacttgt ctgacaggag 1140
agccatacag aacctatacg gctcatgtga aggccccttt gacacagcgt ttgactggat 1200
ctataaagag aagaaccaat acggggagct tgttgttcga tacaacacct acttttttcg 1260
caacagctgg tactggatgt atgagaatcg gagcaacagg acccgatacg gggatccact 1320
tgcaattgcc aacggctggc acggaattcc cgtacagaat attgatgctt ttgttcatgt 1380
ctggacctgg acaagagacg cctcctactt ttttaaaggt actcagtact ggcgctacga 1440
tagtgaaaat gacaaagcct atgctgaaga tgcacaggga aagagctacc ctcgcctaat 1500
ctcagaaggg tttcctggaa tcccaagccc catcaatgct gcctattttg acaggagaag 1560
acagtacatt tacttcttca gggactccca ggtttttgcc tttgatatca acagaaacag 1620
agttgcgcca gacttcccca aaagaatctt ggactttttc ccagccgtcg cagcaaacaa 1680
tcaccccaag ggcaacatag acgtggccta ttattcctac acatacagct ccttatttct 1740
cttcaaagga aaagagtttt ggaaagtcgt cagcgacaag gacaggaggc aaaacccgtc 1800
tcttccatac aatggattgt tccccagaag agcaatatct cagcagtggt ttgatatctg 1860
caacgtacac ccttcattgc tgaaaatttg atttgcccaa aatagcccag cctgaataat 1920
agtcatgcac tgaggttttc taaagtcttc ttctgccctt gtcccacctg tgcactcacc 1980
tgtagcatgg acagcccaaa atagcccagc ctgaataata gtcatccact gaggttttct 2040
aaagtcttct tctgcccttg tcccacctgt gcactcacct gtagcatgga catactccca 2100
gatgattgac ctttctacaa ctctacttcc agagtgtcca tgtctaagaa tttcttagta 2160
aaagagttga ctagactatt gtattgtttc ctaaacgcag ccataaagga gctccaacag 2220
cacaagattc caggaagcca ttccctcaat tcataaagga caggagtgtg cgctccaata 2280
atggctaata tatgtacatt attaaacaca agaatgggag aaatccattc gagaaaaaag 2340
tatttattag ttgagatgaa tcccaatttg ggaagattga gagttgaaca aggatcctta 2400
ttatgtatct gcttaaatgt tttatttatc catttttgct tgagtttctg cttcgattag 2460
gaagtattgg agcatgattc ataatgattg aactgatgtg aacttctcca gaatgcactt 2520
ctaaacacaa acataatact gatggaggag gaataattgt atggggatag aggctccata 2580
gaaggcaaac tttaaggctg caataatatc gtggtcaaat atgtgctttc tcattggtgg 2640
taaaggttta ttgaaggccc tttgcttctt ctgctcaaca gtggaccatg tgctcaaagt 2700
aagctcccta cacaatggtt gatggaaatg tgactggtct gcatgaagcc ctcaacccaa 2760
ctgaacaact gtgggatgaa ttggaccatg gattaaggga gccaggccgg atcattgaag 2820
ccggacctca ctcatgcttt tgtggttgaa gagcaaatcc caccactaat cttccaagac 2880
ctagaggaaa gcctttccag aagagcagag gctgttgcag caaaggaatg tctaactcta 2940
tatcaaaacc ttcaggcttc agaattgcat gttctcatta ataaatgtgt agcatcggga 3000
ctctatagct cttaaaggcc gtgcatgttt gatttagaaa gatacacttg atgttattac 3060
tgagctttat acagcactgt tattctgcac aaataaaact tttactttac aaaaaaaaaa 3120
aaaaaaa                                                           3127

<210> 152
<211> 604
<212> PRT
<213> Xenopus laevis

<220> 
<223> XMMP precursor

<400> 152
Met Pro Ser Ile Lys Leu Leu Val Trp Cys Cys Leu Cys Val Ile Ser
 1               5                  10                  15      
Pro Arg Leu Cys His Ser Glu Lys Leu Phe His Ser Arg Asp Arg Ser
            20                  25                  30          
Asp Leu Gln Pro Ser Ala Ile Glu Gln Ala Glu Leu Val Lys Asp Met
        35                  40                  45              
Leu Ser Ala Gln Gln Phe Leu Ala Lys Tyr Gly Trp Thr Gln Pro Val
    50                  55                  60                  
Ile Trp Asp Pro Ser Ser Thr Asn Glu Asn Glu Pro Leu Lys Asp Phe
65                  70                  75                  80  
Ser Leu Met Gln Glu Gly Val Cys Asn Pro Arg Gln Glu Val Ala Glu
                85                  90                  95      
Pro Thr Lys Ser Pro Gln Phe Ile Asp Ala Leu Lys Lys Phe Gln Lys
            100                 105                 110         
Leu Asn Asn Leu Pro Val Thr Gly Thr Leu Asp Asp Ala Thr Ile Asn
        115                 120                 125             
Ala Met Asn Lys Pro Arg Cys Gly Val Pro Asp Asn Gln Met Ala Lys
    130                 135                 140                 
Lys Glu Thr Glu Lys Pro Thr Ala Ala Gln Ser Leu Glu Asn Lys Thr
145                 150                 155                 160 
Lys Asp Ser Glu Asn Val Thr Gln Gln Asn Pro Asp Pro Pro Lys Ile
                165                 170                 175     
Arg Arg Lys Arg Phe Leu Asp Met Leu Met Tyr Ser Asn Lys Tyr Arg
            180                 185                 190         
Glu Glu Gln Glu Ala Leu Gln Lys Ser Thr Gly Lys Val Phe Thr Lys
        195                 200                 205             
Lys Leu Leu Lys Trp Arg Met Ile Gly Glu Gly Tyr Ser Asn Gln Leu
    210                 215                 220                 
Ser Ile Asn Glu Gln Arg Tyr Val Phe Arg Leu Ala Phe Arg Met Trp
225                 230                 235                 240 
Ser Glu Val Met Pro Leu Asp Phe Glu Glu Asp Asn Thr Ser Pro Leu
                245                 250                 255     
Ser Gln Ile Asp Ile Lys Leu Gly Phe Gly Arg Gly Arg His Leu Gly
            260                 265                 270         
Cys Ser Arg Ala Phe Asp Gly Ser Gly Gln Glu Phe Ala His Ala Trp
        275                 280                 285             
Phe Leu Gly Asp Ile His Phe Asp Asp Asp Glu His Phe Thr Ala Pro
    290                 295                 300                 
Ser Ser Glu His Gly Ile Ser Leu Leu Lys Val Ala Ala His Glu Ile
305                 310                 315                 320 
Gly His Val Leu Gly Leu Ser His Ile His Arg Val Gly Ser Ile Met
                325                 330                 335     
Gln Pro Asn Tyr Ile Pro Gln Asp Ser Gly Phe Glu Leu Asp Leu Ser
            340                 345                 350         
Asp Arg Arg Ala Ile Gln Asn Leu Tyr Gly Ser Cys Glu Gly Pro Phe
        355                 360                 365             
Asp Thr Ala Phe Asp Trp Ile Tyr Lys Glu Lys Asn Gln Tyr Gly Glu
    370                 375                 380                 
Leu Val Val Arg Tyr Asn Thr Tyr Phe Phe Arg Asn Ser Trp Tyr Trp
385                 390                 395                 400 
Met Tyr Glu Asn Arg Ser Asn Arg Thr Arg Tyr Gly Asp Pro Leu Ala
                405                 410                 415     
Ile Ala Asn Gly Trp His Gly Ile Pro Val Gln Asn Ile Asp Ala Phe
            420                 425                 430         
Val His Val Trp Thr Trp Thr Arg Asp Ala Ser Tyr Phe Phe Lys Gly
        435                 440                 445             
Thr Gln Tyr Trp Arg Tyr Asp Ser Glu Asn Asp Lys Ala Tyr Ala Glu
    450                 455                 460                 
Asp Ala Gln Gly Lys Ser Tyr Pro Arg Leu Ile Ser Glu Gly Phe Pro
465                 470                 475                 480 
Gly Ile Pro Ser Pro Ile Asn Ala Ala Tyr Phe Asp Arg Arg Arg Gln
                485                 490                 495     
Tyr Ile Tyr Phe Phe Arg Asp Ser Gln Val Phe Ala Phe Asp Ile Asn
            500                 505                 510         
Arg Asn Arg Val Ala Pro Asp Phe Pro Lys Arg Ile Leu Asp Phe Phe
        515                 520                 525             
Pro Ala Val Ala Ala Asn Asn His Pro Lys Gly Asn Ile Asp Val Ala
    530                 535                 540                 
Tyr Tyr Ser Tyr Thr Tyr Ser Ser Leu Phe Leu Phe Lys Gly Lys Glu
545                 550                 555                 560 
Phe Trp Lys Val Val Ser Asp Lys Asp Arg Arg Gln Asn Pro Ser Leu
                565                 570                 575     
Pro Tyr Asn Gly Leu Phe Pro Arg Arg Ala Ile Ser Gln Gln Trp Phe
            580                 585                 590         
Asp Ile Cys Asn Val His Pro Ser Leu Leu Lys Ile
        595                 600                 


<210> 153
<211> 420
<212> PRT
<213> Xenopus laevis

<220> 
<223> XMMP mature

<400> 153
Phe Leu Asp Met Leu Met Tyr Ser Asn Lys Tyr Arg Glu Glu Gln Glu
 1               5                  10                  15      
Ala Leu Gln Lys Ser Thr Gly Lys Val Phe Thr Lys Lys Leu Leu Lys
            20                  25                  30          
Trp Arg Met Ile Gly Glu Gly Tyr Ser Asn Gln Leu Ser Ile Asn Glu
        35                  40                  45              
Gln Arg Tyr Val Phe Arg Leu Ala Phe Arg Met Trp Ser Glu Val Met
    50                  55                  60                  
Pro Leu Asp Phe Glu Glu Asp Asn Thr Ser Pro Leu Ser Gln Ile Asp
65                  70                  75                  80  
Ile Lys Leu Gly Phe Gly Arg Gly Arg His Leu Gly Cys Ser Arg Ala
                85                  90                  95      
Phe Asp Gly Ser Gly Gln Glu Phe Ala His Ala Trp Phe Leu Gly Asp
            100                 105                 110         
Ile His Phe Asp Asp Asp Glu His Phe Thr Ala Pro Ser Ser Glu His
        115                 120                 125             
Gly Ile Ser Leu Leu Lys Val Ala Ala His Glu Ile Gly His Val Leu
    130                 135                 140                 
Gly Leu Ser His Ile His Arg Val Gly Ser Ile Met Gln Pro Asn Tyr
145                 150                 155                 160 
Ile Pro Gln Asp Ser Gly Phe Glu Leu Asp Leu Ser Asp Arg Arg Ala
                165                 170                 175     
Ile Gln Asn Leu Tyr Gly Ser Cys Glu Gly Pro Phe Asp Thr Ala Phe
            180                 185                 190         
Asp Trp Ile Tyr Lys Glu Lys Asn Gln Tyr Gly Glu Leu Val Val Arg
        195                 200                 205             
Tyr Asn Thr Tyr Phe Phe Arg Asn Ser Trp Tyr Trp Met Tyr Glu Asn
    210                 215                 220                 
Arg Ser Asn Arg Thr Arg Tyr Gly Asp Pro Leu Ala Ile Ala Asn Gly
225                 230                 235                 240 
Trp His Gly Ile Pro Val Gln Asn Ile Asp Ala Phe Val His Val Trp
                245                 250                 255     
Thr Trp Thr Arg Asp Ala Ser Tyr Phe Phe Lys Gly Thr Gln Tyr Trp
            260                 265                 270         
Arg Tyr Asp Ser Glu Asn Asp Lys Ala Tyr Ala Glu Asp Ala Gln Gly
        275                 280                 285             
Lys Ser Tyr Pro Arg Leu Ile Ser Glu Gly Phe Pro Gly Ile Pro Ser
    290                 295                 300                 
Pro Ile Asn Ala Ala Tyr Phe Asp Arg Arg Arg Gln Tyr Ile Tyr Phe
305                 310                 315                 320 
Phe Arg Asp Ser Gln Val Phe Ala Phe Asp Ile Asn Arg Asn Arg Val
                325                 330                 335     
Ala Pro Asp Phe Pro Lys Arg Ile Leu Asp Phe Phe Pro Ala Val Ala
            340                 345                 350         
Ala Asn Asn His Pro Lys Gly Asn Ile Asp Val Ala Tyr Tyr Ser Tyr
        355                 360                 365             
Thr Tyr Ser Ser Leu Phe Leu Phe Lys Gly Lys Glu Phe Trp Lys Val
    370                 375                 380                 
Val Ser Asp Lys Asp Arg Arg Gln Asn Pro Ser Leu Pro Tyr Asn Gly
385                 390                 395                 400 
Leu Phe Pro Arg Arg Ala Ile Ser Gln Gln Trp Phe Asp Ile Cys Asn
                405                 410                 415     
Val His Pro Ser
            420 


<210> 154
<211> 1694
<212> DNA
<213> Homo sapiens

<220> 
<223> heparanase

<400> 154
gggcaccagc caagatgctg ctgcgctcga agcctgcgct gccgccgccg ctgatgctgc 60
tgctcctggg gccgctgggt cccctctccc ctggcgccct gccccgacct gcgcaagcac 120
aggacgtcgt ggacctggac ttcttcaccc aggagccgct gcacctggtg agcccctcgt 180
tcctgtccgt caccattgac gccaacctgg ccacggaccc gcggttcctc atcctcctgg 240
gttctccaaa gcttcgtacc ttggccagag gcttgtctcc tgcgtacctg aggtttggtg 300
gcaccaagac agacttccta attttcgatc ccaagaagga atcaaccttt gaagagagaa 360
gttactggca atctcaagtc aaccaggata tttgcaaata tggatccatc cctcctgatg 420
tggaggagaa gttacggttg gaatggccct accaggagca attgctactc cgagaacact 480
accagaaaaa gttcaagaac agcacctact caagaagctc tgtagatgtg ctatacactt 540
ttgcaaactg ctcaggactg gacttgatct ttggcctaaa tgcgttatta agaacagcag 600
atttgcagtg gaacagttct aatgctcagt tgctcctgga ctactgctct tccaaggggt 660
ataacatttc ttgggaacta ggcaatgaac ctaacagttt ccttaagaag gctgatattt 720
tcatcaatgg gtcgcagtta ggagaagatt ttattcaatt gcataaactt ctaagaaagt 780
ccaccttcaa aaatgcaaaa ctctatggtc ctgatgttgg tcagcctcga agaaagacgg 840
ctaagatgct gaagagcttc ctgaaggctg gtggagaagt gattgattca gttacatggc 900
atcactacta tttgaatgga cggactgcta ccagggaaga ttttctaaac cctgatgtat 960
tggacatttt tatttcatct gtgcaaaaag ttttccaggt ggttgagagc accaggcctg 1020
gcaagaaggt ctggttagga gaaacaagct ctgcatatgg aggcggagcg cccttgctat 1080
ccgacacctt tgcagctggc tttatgtggc tggataaatt gggcctgtca gcccgaatgg 1140
gaatagaagt ggtgatgagg caagtattct ttggagcagg aaactaccat ttagtggatg 1200
aaaacttcga tcctttacct gattattggc tatctcttct gttcaagaaa ttggtgggca 1260
ccaaggtgtt aatggcaagc gtgcaaggtt caaagagaag gaagcttcga gtataccttc 1320
attgcacaaa cactgacaat ccaaggtata aagaaggaga tttaactctg tatgccataa 1380
acctccataa tgtcaccaag tacttgcggt taccctatcc tttttctaac aagcaagtgg 1440
ataaatacct tctaagacct ttgggacctc atggattact ttccaaatct gtccaactca 1500
atggtctaac tctaaagatg gtggatgatc aaaccttgcc acctttaatg gaaaaacctc 1560
tccggccagg aagttcactg ggcttgccag ctttctcata tagttttttt gtgataagaa 1620
atgccaaagt tgctgcttgc atctgaaaat aaaatatact agtcctgaca ctgaaaaaaa 1680
aaaaaaaaaa aaaa                                                   1694

<210> 155
<211> 543
<212> PRT
<213> Homo sapiens

<220> 
<223> heparanase precursor

<400> 155
Met Leu Leu Arg Ser Lys Pro Ala Leu Pro Pro Pro Leu Met Leu Leu
 1               5                  10                  15      
Leu Leu Gly Pro Leu Gly Pro Leu Ser Pro Gly Ala Leu Pro Arg Pro
            20                  25                  30          
Ala Gln Ala Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro
        35                  40                  45              
Leu His Leu Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn
    50                  55                  60                  
Leu Ala Thr Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu
65                  70                  75                  80  
Arg Thr Leu Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly
                85                  90                  95      
Thr Lys Thr Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Ser Thr Phe
            100                 105                 110         
Glu Glu Arg Ser Tyr Trp Gln Ser Gln Val Asn Gln Asp Ile Cys Lys
        115                 120                 125             
Tyr Gly Ser Ile Pro Pro Asp Val Glu Glu Lys Leu Arg Leu Glu Trp
    130                 135                 140                 
Pro Tyr Gln Glu Gln Leu Leu Leu Arg Glu His Tyr Gln Lys Lys Phe
145                 150                 155                 160 
Lys Asn Ser Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe
                165                 170                 175     
Ala Asn Cys Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu
            180                 185                 190         
Arg Thr Ala Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu
        195                 200                 205             
Asp Tyr Cys Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn
    210                 215                 220                 
Glu Pro Asn Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser
225                 230                 235                 240 
Gln Leu Gly Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser
                245                 250                 255     
Thr Phe Lys Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg
            260                 265                 270         
Arg Lys Thr Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu
        275                 280                 285             
Val Ile Asp Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr
    290                 295                 300                 
Ala Thr Arg Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile
305                 310                 315                 320 
Ser Ser Val Gln Lys Val Phe Gln Val Val Glu Ser Thr Arg Pro Gly
                325                 330                 335     
Lys Lys Val Trp Leu Gly Glu Thr Ser Ser Ala Tyr Gly Gly Gly Ala
            340                 345                 350         
Pro Leu Leu Ser Asp Thr Phe Ala Ala Gly Phe Met Trp Leu Asp Lys
        355                 360                 365             
Leu Gly Leu Ser Ala Arg Met Gly Ile Glu Val Val Met Arg Gln Val
    370                 375                 380                 
Phe Phe Gly Ala Gly Asn Tyr His Leu Val Asp Glu Asn Phe Asp Pro
385                 390                 395                 400 
Leu Pro Asp Tyr Trp Leu Ser Leu Leu Phe Lys Lys Leu Val Gly Thr
                405                 410                 415     
Lys Val Leu Met Ala Ser Val Gln Gly Ser Lys Arg Arg Lys Leu Arg
            420                 425                 430         
Val Tyr Leu His Cys Thr Asn Thr Asp Asn Pro Arg Tyr Lys Glu Gly
        435                 440                 445             
Asp Leu Thr Leu Tyr Ala Ile Asn Leu His Asn Val Thr Lys Tyr Leu
    450                 455                 460                 
Arg Leu Pro Tyr Pro Phe Ser Asn Lys Gln Val Asp Lys Tyr Leu Leu
465                 470                 475                 480 
Arg Pro Leu Gly Pro His Gly Leu Leu Ser Lys Ser Val Gln Leu Asn
                485                 490                 495     
Gly Leu Thr Leu Lys Met Val Asp Asp Gln Thr Leu Pro Pro Leu Met
            500                 505                 510         
Glu Lys Pro Leu Arg Pro Gly Ser Ser Leu Gly Leu Pro Ala Phe Ser
        515                 520                 525             
Tyr Ser Phe Phe Val Ile Arg Asn Ala Lys Val Ala Ala Cys Ile
    530                 535                 540             


<210> 156
<211> 460
<212> PRT
<213> Homo sapiens

<220> 
<223> heparanase mature

<220> 
<223> heparanase 8 kDa subunit

<220> 
<223> heparanase 50 kDa subunit

<400> 156
Gln Asp Val Val Asp Leu Asp Phe Phe Thr Gln Glu Pro Leu His Leu
 1               5                  10                  15      
Val Ser Pro Ser Phe Leu Ser Val Thr Ile Asp Ala Asn Leu Ala Thr
            20                  25                  30          
Asp Pro Arg Phe Leu Ile Leu Leu Gly Ser Pro Lys Leu Arg Thr Leu
        35                  40                  45              
Ala Arg Gly Leu Ser Pro Ala Tyr Leu Arg Phe Gly Gly Thr Lys Thr
    50                  55                  60                  
Asp Phe Leu Ile Phe Asp Pro Lys Lys Glu Lys Lys Phe Lys Asn Ser
65                  70                  75                  80  
Thr Tyr Ser Arg Ser Ser Val Asp Val Leu Tyr Thr Phe Ala Asn Cys
                85                  90                  95      
Ser Gly Leu Asp Leu Ile Phe Gly Leu Asn Ala Leu Leu Arg Thr Ala
            100                 105                 110         
Asp Leu Gln Trp Asn Ser Ser Asn Ala Gln Leu Leu Leu Asp Tyr Cys
        115                 120                 125             
Ser Ser Lys Gly Tyr Asn Ile Ser Trp Glu Leu Gly Asn Glu Pro Asn
    130                 135                 140                 
Ser Phe Leu Lys Lys Ala Asp Ile Phe Ile Asn Gly Ser Gln Leu Gly
145                 150                 155                 160 
Glu Asp Phe Ile Gln Leu His Lys Leu Leu Arg Lys Ser Thr Phe Lys
                165                 170                 175     
Asn Ala Lys Leu Tyr Gly Pro Asp Val Gly Gln Pro Arg Arg Lys Thr
            180                 185                 190         
Ala Lys Met Leu Lys Ser Phe Leu Lys Ala Gly Gly Glu Val Ile Asp
        195                 200                 205             
Ser Val Thr Trp His His Tyr Tyr Leu Asn Gly Arg Thr Ala Thr Arg
    210                 215                 220                 
Glu Asp Phe Leu Asn Pro Asp Val Leu Asp Ile Phe Ile Ser Ser Val
225                 230                 235                 240 
Gln Lys Val Phe Gln Val Val Glu Ser Thr Arg Pro Gly Lys Lys Val
                245                 250                 255     
Trp Leu Gly Glu Thr Ser Ser Ala Tyr Gly Gly Gly Ala Pro Leu Leu
            260                 265                 270         
Ser Asp Thr Phe Ala Ala Gly Phe Met Trp Leu Asp Lys Leu Gly Leu
        275                 280                 285             
Ser Ala Arg Met Gly Ile Glu Val Val Met Arg Gln Val Phe Phe Gly
    290                 295                 300                 
Ala Gly Asn Tyr His Leu Val Asp Glu Asn Phe Asp Pro Leu Pro Asp
305                 310                 315                 320 
Tyr Trp Leu Ser Leu Leu Phe Lys Lys Leu Val Gly Thr Lys Val Leu
                325                 330                 335     
Met Ala Ser Val Gln Gly Ser Lys Arg Arg Lys Leu Arg Val Tyr Leu
            340                 345                 350         
His Cys Thr Asn Thr Asp Asn Pro Arg Tyr Lys Glu Gly Asp Leu Thr
        355                 360                 365             
Leu Tyr Ala Ile Asn Leu His Asn Val Thr Lys Tyr Leu Arg Leu Pro
    370                 375                 380                 
Tyr Pro Phe Ser Asn Lys Gln Val Asp Lys Tyr Leu Leu Arg Pro Leu
385                 390                 395                 400 
Gly Pro His Gly Leu Leu Ser Lys Ser Val Gln Leu Asn Gly Leu Thr
                405                 410                 415     
Leu Lys Met Val Asp Asp Gln Thr Leu Pro Pro Leu Met Glu Lys Pro
            420                 425                 430         
Leu Arg Pro Gly Ser Ser Leu Gly Leu Pro Ala Phe Ser Tyr Ser Phe
        435                 440                 445             
Phe Val Ile Arg Asn Ala Lys Val Ala Ala Cys Ile
    450                 455                 460 


<210> 157
<211> 4670
<212> DNA
<213> Homo sapiens

<220> 
<223> ADAMTS-1

<400> 157
gcactcgctg gaaagcggct ccgagccagg ggctattgca aagccagggt gcgctaccgg 60
acggagaggg gagagccctg agcagagtga gcaacatcgc agccaaggcg gaggccgaag 120
aggggcgcca ggcaccaatc tccgcgttgc ctcagccccg gaggcgcccc agagcgcttc 180
ttgtcccagc agagccactc tgcctgcgcc tgcctctcag tgtctccaac tttgcgctgg 240
aagaaaaact tcccgcgcgc cggcagaact gcagcgcctc cttttagtga ctccgggagc 300
ttcggctgta gccggctctg cgcgcccttc caacgaataa tagaaattgt taattttaac 360
aatccagagc aggccaacga ggctttgctc tcccgacccg aactaaaggt ccctcgctcc 420
gtgcgctgct acgagcggtg tctcctgggg ctccaatgca gcgagctgtg cccgaggggt 480
tcggaaggcg caagctgggc agcgacatgg ggaacgcgga gcgggctccg gggtctcgga 540
gctttgggcc cgtacccacg ctgctgctgc tcgccgcggc gctactggcc gtgtcggacg 600
cactcgggcg cccctccgag gaggacgagg agctagtggt gccggagctg gagcgcgccc 660
cgggacacgg gaccacgcgc ctccgcctgc acgcctttga ccagcagctg gatctggagc 720
tgcggcccga cagcagcttt ttggcgcccg gcttcacgct ccagaacgtg gggcgcaaat 780
ccgggtccga gacgccgctt ccggaaaccg acctggcgca ctgcttctac tccggcaccg 840
tgaatggcga tcccagctcg gctgccgccc tcagcctctg cgagggcgtg cgcggcgcct 900
tctacctgct gggggaggcg tatttcatcc agccgctgcc cgccgccagc gagcgcctcg 960
ccaccgccgc cccaggggag aagccgccgg caccactaca gttccacctc ctgcggcgga 1020
atcggcaggg cgacgtcggc ggcacgtgcg gggtcgtgga cgacgagccc cggccgactg 1080
ggaaagcgga gaccgaagac gaggacgaag ggactgaggg cgaggacgaa ggggctcagt 1140
ggtcgccgca ggacccggca ctgcaaggcg taggacagcc cacaggaact ggaagcataa 1200
gaaagaagcg atttgtgtcc agtcaccgct atgtggaaac catgcttgtg gcagaccagt 1260
cgatggcaga attccacggc agtggtctaa agcattacct tctcacgttg ttttcggtgg 1320
cagccagatt gtacaaacac cccagcattc gtaattcagt tagcctggtg gtggtgaaga 1380
tcttggtcat ccacgatgaa cagaaggggc cggaagtgac ctccaatgct gccctcactc 1440
tgcggaactt ttgcaactgg cagaagcagc acaacccacc cagtgaccgg gatgcagagc 1500
actatgacac agcaattctt ttcaccagac aggacttgtg tgggtcccag acatgtgata 1560
ctcttgggat ggctgatgtt ggaactgtgt gtgatccgag cagaagctgc tccgtcatag 1620
aagatgatgg tttacaagct gccttcacca cagcccatga attaggccac gtgtttaaca 1680
tgccacatga tgatgcaaag cagtgtgcca gccttaatgg tgtgaaccag gattcccaca 1740
tgatggcgtc aatgctttcc aacctggacc acagccagcc ttggtctcct tgcagtgcct 1800
acatgattac atcatttctg gataatggtc atggggaatg tttgatggac aagcctcaga 1860
atcccataca gctcccaggc gatctccctg gcacctcgta cgatgccaac cggcagtgcc 1920
agtttacatt tggggaggac tccaaacact gccccgatgc agccagcaca tgtagcacct 1980
tgtggtgtac cggcacctct ggtggggtgc tggtgtgtca aaccaaacac ttcccgtggg 2040
cggatggcac cagctgtgga gaagggaaat ggtgtatcaa cggcaagtgt gtgaacaaaa 2100
ccgacagaaa gcattttgat acgccttttc atggaagctg gggaatgtgg gggccttggg 2160
gagactgttc gagaacgtgc ggtggaggag tccagtacac gatgagggaa tgtgacaacc 2220
cagtcccaaa gaatggaggg aagtactgtg aaggcaaacg agtgcgctac agatcctgta 2280
accttgagga ctgtccagac aataatggaa aaacctttag agaggaacaa tgtgaagcac 2340
acaacgagtt ttcaaaagct tcctttggga gtgggcctgc ggtggaatgg attcccaagt 2400
acgctggcgt ctcaccaaag gacaggtgca agctcatctg ccaagccaaa ggcattggct 2460
acttcttcgt tttgcagccc aaggttgtag atggtactcc atgtagccca gattccacct 2520
ctgtctgtgt gcaaggacag tgtgtaaaag ctggttgtga tcgcatcata gactccaaaa 2580
agaagtttga taaatgtggt gtttgcgggg gaaatggatc tacttgtaaa aaaatatcag 2640
gatcagttac tagtgcaaaa cctggatatc atgatatcat cacaattcca actggagcca 2700
ccaacatcga agtgaaacag cggaaccaga ggggatccag gaacaatggc agctttcttg 2760
ccatcaaagc tgctgatggc acatatattc ttaatggtga ctacactttg tccaccttag 2820
agcaagacat tatgtacaaa ggtgttgtct tgaggtacag cggctcctct gcggcattgg 2880
aaagaattcg cagctttagc cctctcaaag agcccttgac catccaggtt cttactgtgg 2940
gcaatgccct tcgacctaaa attaaataca cctacttcgt aaagaagaag aaggaatctt 3000
tcaatgctat ccccactttt tcagcatggg tcattgaaga gtggggcgaa tgttctaagt 3060
catgtgaatt gggttggcag agaagactgg tagaatgccg agacattaat ggacagcctg 3120
cttccgagtg tgcaaaggaa gtgaagccag ccagcaccag accttgtgca gaccatccct 3180
gcccccagtg gcagctgggg gagtggtcat catgttctaa gacctgtggg aagggttaca 3240
aaaaaagaag cttgaagtgt ctgtcccatg atggaggggt gttatctcat gagagctgtg 3300
atcctttaaa gaaacctaaa catttcatag acttttgcac aatggcagaa tgcagttaag 3360
tggtttaagt ggtgttagct ttgagggcaa ggcaaagtga ggaagggctg gtgcagggaa 3420
agcaagaagg ctggagggat ccagcgtatc ttgccagtaa ccagtgaggt gtatcagtaa 3480
ggtgggatta tgggggtaga tagaaaagga gttgaatcat cagagtaaac tgccagttgc 3540
aaatttgata ggatagttag tgaggattat taacctctga gcagtgatat agcataataa 3600
agccccgggc attattatta ttatttcttt tgttacatct attacaagtt tagaaaaaac 3660
aaagcaattg tcaaaaaaag ttagaactat tacaacccct gtttcctggt acttatcaaa 3720
tacttagtat catgggggtt gggaaatgaa aagtaggaga aaagtgagat tttactaaga 3780
cctgttttac tttacctcac taacaatggg gggagaaagg agtacaaata ggatctttga 3840
ccagcactgt ttatggctgc tatggtttca gagaatgttt atacattatt tctaccgaga 3900
attaaaactt cagattgttc aacatgagag aaaggctcag caacgtgaaa taacgcaaat 3960
ggcttcctct ttcctttttt ggaccatctc agtctttatt tgtgtaattc attttgagga 4020
aaaaacaact ccatgtattt attcaagtgc attaaagtct acaatggaaa aaaagcagtg 4080
aagcattaga tgctggtaaa agctagagga gacacaatga gcttagtacc tccaacttcc 4140
tttctttcct accatgtaac cctgctttgg gaatatggat gtaaagaagt aacttgtgtc 4200
tcatgaaaat cagtacaatc acacaaggag gatgaaacgc cggaacaaaa atgaggtgtg 4260
tagaacaggg tcccacaggt ttggggacat tgagatcact tgtcttgtgg tggggaggct 4320
gctgaggggt agcaggtcca tctccagcag ctggtccaac agtcgtatcc tggtgaatgt 4380
ctgttcagct cttctgtgag aatatgattt tttccatatg tatatagtaa aatatgttac 4440
tataaattac atgtacttta taagtattgg tttgggtgtt ccttccaaga aggactatag 4500
ttagtaataa atgcctataa taacatattt atttttatac atttatttct aatgaaaaaa 4560
acttttaaat tatatcgctt ttgtggaagt gcatataaaa tagagtattt atacaatata 4620
tgttactaga aataaaagaa cacttttgga aaaaaaaaaa aaaaaaaaaa            4670

<210> 158
<211> 967
<212> PRT
<213> Homo sapiens  `

<220> 
<223> ADAMTS- precursor

<400> 158
Met Gln Arg Ala Val Pro Glu Gly Phe Gly Arg Arg Lys Leu Gly Ser
 1               5                  10                  15      
Asp Met Gly Asn Ala Glu Arg Ala Pro Gly Ser Arg Ser Phe Gly Pro
            20                  25                  30          
Val Pro Thr Leu Leu Leu Leu Ala Ala Ala Leu Leu Ala Val Ser Asp
        35                  40                  45              
Ala Leu Gly Arg Pro Ser Glu Glu Asp Glu Glu Leu Val Val Pro Glu
    50                  55                  60                  
Leu Glu Arg Ala Pro Gly His Gly Thr Thr Arg Leu Arg Leu His Ala
65                  70                  75                  80  
Phe Asp Gln Gln Leu Asp Leu Glu Leu Arg Pro Asp Ser Ser Phe Leu
                85                  90                  95      
Ala Pro Gly Phe Thr Leu Gln Asn Val Gly Arg Lys Ser Gly Ser Glu
            100                 105                 110         
Thr Pro Leu Pro Glu Thr Asp Leu Ala His Cys Phe Tyr Ser Gly Thr
        115                 120                 125             
Val Asn Gly Asp Pro Ser Ser Ala Ala Ala Leu Ser Leu Cys Glu Gly
    130                 135                 140                 
Val Arg Gly Ala Phe Tyr Leu Leu Gly Glu Ala Tyr Phe Ile Gln Pro
145                 150                 155                 160 
Leu Pro Ala Ala Ser Glu Arg Leu Ala Thr Ala Ala Pro Gly Glu Lys
                165                 170                 175     
Pro Pro Ala Pro Leu Gln Phe His Leu Leu Arg Arg Asn Arg Gln Gly
            180                 185                 190         
Asp Val Gly Gly Thr Cys Gly Val Val Asp Asp Glu Pro Arg Pro Thr
        195                 200                 205             
Gly Lys Ala Glu Thr Glu Asp Glu Asp Glu Gly Thr Glu Gly Glu Asp
    210                 215                 220                 
Glu Gly Ala Gln Trp Ser Pro Gln Asp Pro Ala Leu Gln Gly Val Gly
225                 230                 235                 240 
Gln Pro Thr Gly Thr Gly Ser Ile Arg Lys Lys Arg Phe Val Ser Ser
                245                 250                 255     
His Arg Tyr Val Glu Thr Met Leu Val Ala Asp Gln Ser Met Ala Glu
            260                 265                 270         
Phe His Gly Ser Gly Leu Lys His Tyr Leu Leu Thr Leu Phe Ser Val
        275                 280                 285             
Ala Ala Arg Leu Tyr Lys His Pro Ser Ile Arg Asn Ser Val Ser Leu
    290                 295                 300                 
Val Val Val Lys Ile Leu Val Ile His Asp Glu Gln Lys Gly Pro Glu
305                 310                 315                 320 
Val Thr Ser Asn Ala Ala Leu Thr Leu Arg Asn Phe Cys Asn Trp Gln
                325                 330                 335     
Lys Gln His Asn Pro Pro Ser Asp Arg Asp Ala Glu His Tyr Asp Thr
            340                 345                 350         
Ala Ile Leu Phe Thr Arg Gln Asp Leu Cys Gly Ser Gln Thr Cys Asp
        355                 360                 365             
Thr Leu Gly Met Ala Asp Val Gly Thr Val Cys Asp Pro Ser Arg Ser
    370                 375                 380                 
Cys Ser Val Ile Glu Asp Asp Gly Leu Gln Ala Ala Phe Thr Thr Ala
385                 390                 395                 400 
His Glu Leu Gly His Val Phe Asn Met Pro His Asp Asp Ala Lys Gln
                405                 410                 415     
Cys Ala Ser Leu Asn Gly Val Asn Gln Asp Ser His Met Met Ala Ser
            420                 425                 430         
Met Leu Ser Asn Leu Asp His Ser Gln Pro Trp Ser Pro Cys Ser Ala
        435                 440                 445             
Tyr Met Ile Thr Ser Phe Leu Asp Asn Gly His Gly Glu Cys Leu Met
    450                 455                 460                 
Asp Lys Pro Gln Asn Pro Ile Gln Leu Pro Gly Asp Leu Pro Gly Thr
465                 470                 475                 480 
Ser Tyr Asp Ala Asn Arg Gln Cys Gln Phe Thr Phe Gly Glu Asp Ser
                485                 490                 495     
Lys His Cys Pro Asp Ala Ala Ser Thr Cys Ser Thr Leu Trp Cys Thr
            500                 505                 510         
Gly Thr Ser Gly Gly Val Leu Val Cys Gln Thr Lys His Phe Pro Trp
        515                 520                 525             
Ala Asp Gly Thr Ser Cys Gly Glu Gly Lys Trp Cys Ile Asn Gly Lys
    530                 535                 540                 
Cys Val Asn Lys Thr Asp Arg Lys His Phe Asp Thr Pro Phe His Gly
545                 550                 555                 560 
Ser Trp Gly Met Trp Gly Pro Trp Gly Asp Cys Ser Arg Thr Cys Gly
                565                 570                 575     
Gly Gly Val Gln Tyr Thr Met Arg Glu Cys Asp Asn Pro Val Pro Lys
            580                 585                 590         
Asn Gly Gly Lys Tyr Cys Glu Gly Lys Arg Val Arg Tyr Arg Ser Cys
        595                 600                 605             
Asn Leu Glu Asp Cys Pro Asp Asn Asn Gly Lys Thr Phe Arg Glu Glu
    610                 615                 620                 
Gln Cys Glu Ala His Asn Glu Phe Ser Lys Ala Ser Phe Gly Ser Gly
625                 630                 635                 640 
Pro Ala Val Glu Trp Ile Pro Lys Tyr Ala Gly Val Ser Pro Lys Asp
                645                 650                 655     
Arg Cys Lys Leu Ile Cys Gln Ala Lys Gly Ile Gly Tyr Phe Phe Val
            660                 665                 670         
Leu Gln Pro Lys Val Val Asp Gly Thr Pro Cys Ser Pro Asp Ser Thr
        675                 680                 685             
Ser Val Cys Val Gln Gly Gln Cys Val Lys Ala Gly Cys Asp Arg Ile
    690                 695                 700                 
Ile Asp Ser Lys Lys Lys Phe Asp Lys Cys Gly Val Cys Gly Gly Asn
705                 710                 715                 720 
Gly Ser Thr Cys Lys Lys Ile Ser Gly Ser Val Thr Ser Ala Lys Pro
                725                 730                 735     
Gly Tyr His Asp Ile Ile Thr Ile Pro Thr Gly Ala Thr Asn Ile Glu
            740                 745                 750         
Val Lys Gln Arg Asn Gln Arg Gly Ser Arg Asn Asn Gly Ser Phe Leu
        755                 760                 765             
Ala Ile Lys Ala Ala Asp Gly Thr Tyr Ile Leu Asn Gly Asp Tyr Thr
    770                 775                 780                 
Leu Ser Thr Leu Glu Gln Asp Ile Met Tyr Lys Gly Val Val Leu Arg
785                 790                 795                 800 
Tyr Ser Gly Ser Ser Ala Ala Leu Glu Arg Ile Arg Ser Phe Ser Pro
                805                 810                 815     
Leu Lys Glu Pro Leu Thr Ile Gln Val Leu Thr Val Gly Asn Ala Leu
            820                 825                 830         
Arg Pro Lys Ile Lys Tyr Thr Tyr Phe Val Lys Lys Lys Lys Glu Ser
        835                 840                 845             
Phe Asn Ala Ile Pro Thr Phe Ser Ala Trp Val Ile Glu Glu Trp Gly
    850                 855                 860                 
Glu Cys Ser Lys Ser Cys Glu Leu Gly Trp Gln Arg Arg Leu Val Glu
865                 870                 875                 880 
Cys Arg Asp Ile Asn Gly Gln Pro Ala Ser Glu Cys Ala Lys Glu Val
                885                 890                 895     
Lys Pro Ala Ser Thr Arg Pro Cys Ala Asp His Pro Cys Pro Gln Trp
            900                 905                 910         
Gln Leu Gly Glu Trp Ser Ser Cys Ser Lys Thr Cys Gly Lys Gly Tyr
        915                 920                 925             
Lys Lys Arg Ser Leu Lys Cys Leu Ser His Asp Gly Gly Val Leu Ser
    930                 935                 940                 
His Glu Ser Cys Asp Pro Leu Lys Lys Pro Lys His Phe Ile Asp Phe
945                 950                 955                 960 
Cys Thr Met Ala Glu Cys Ser
                965         


<210> 159
<211> 715
<212> PRT
<213> Homo sapiens

<220> 
<223> ADAMTS-1 mature

<400> 159
Phe Val Ser Ser His Arg Tyr Val Glu Thr Met Leu Val Ala Asp Gln
 1               5                  10                  15      
Ser Met Ala Glu Phe His Gly Ser Gly Leu Lys His Tyr Leu Leu Thr
            20                  25                  30          
Leu Phe Ser Val Ala Ala Arg Leu Tyr Lys His Pro Ser Ile Arg Asn
        35                  40                  45              
Ser Val Ser Leu Val Val Val Lys Ile Leu Val Ile His Asp Glu Gln
    50                  55                  60                  
Lys Gly Pro Glu Val Thr Ser Asn Ala Ala Leu Thr Leu Arg Asn Phe
65                  70                  75                  80  
Cys Asn Trp Gln Lys Gln His Asn Pro Pro Ser Asp Arg Asp Ala Glu
                85                  90                  95      

His Tyr Asp Thr Ala Ile Leu Phe Thr Arg Gln Asp Leu Cys Gly Ser
            100                 105                 110         
Gln Thr Cys Asp Thr Leu Gly Met Ala Asp Val Gly Thr Val Cys Asp
        115                 120                 125             
Pro Ser Arg Ser Cys Ser Val Ile Glu Asp Asp Gly Leu Gln Ala Ala
    130                 135                 140                 
Phe Thr Thr Ala His Glu Leu Gly His Val Phe Asn Met Pro His Asp
145                 150                 155                 160 
Asp Ala Lys Gln Cys Ala Ser Leu Asn Gly Val Asn Gln Asp Ser His
                165                 170                 175     
Met Met Ala Ser Met Leu Ser Asn Leu Asp His Ser Gln Pro Trp Ser
            180                 185                 190         
Pro Cys Ser Ala Tyr Met Ile Thr Ser Phe Leu Asp Asn Gly His Gly
        195                 200                 205             
Glu Cys Leu Met Asp Lys Pro Gln Asn Pro Ile Gln Leu Pro Gly Asp
    210                 215                 220                 
Leu Pro Gly Thr Ser Tyr Asp Ala Asn Arg Gln Cys Gln Phe Thr Phe
225                 230                 235                 240 
Gly Glu Asp Ser Lys His Cys Pro Asp Ala Ala Ser Thr Cys Ser Thr
                245                 250                 255     
Leu Trp Cys Thr Gly Thr Ser Gly Gly Val Leu Val Cys Gln Thr Lys
            260                 265                 270         
His Phe Pro Trp Ala Asp Gly Thr Ser Cys Gly Glu Gly Lys Trp Cys
        275                 280                 285             
Ile Asn Gly Lys Cys Val Asn Lys Thr Asp Arg Lys His Phe Asp Thr
    290                 295                 300                 
Pro Phe His Gly Ser Trp Gly Met Trp Gly Pro Trp Gly Asp Cys Ser
305                 310                 315                 320 
Arg Thr Cys Gly Gly Gly Val Gln Tyr Thr Met Arg Glu Cys Asp Asn
                325                 330                 335     
Pro Val Pro Lys Asn Gly Gly Lys Tyr Cys Glu Gly Lys Arg Val Arg
            340                 345                 350         
Tyr Arg Ser Cys Asn Leu Glu Asp Cys Pro Asp Asn Asn Gly Lys Thr
        355                 360                 365             
Phe Arg Glu Glu Gln Cys Glu Ala His Asn Glu Phe Ser Lys Ala Ser
    370                 375                 380                 
Phe Gly Ser Gly Pro Ala Val Glu Trp Ile Pro Lys Tyr Ala Gly Val
385                 390                 395                 400 
Ser Pro Lys Asp Arg Cys Lys Leu Ile Cys Gln Ala Lys Gly Ile Gly
                405                 410                 415     
Tyr Phe Phe Val Leu Gln Pro Lys Val Val Asp Gly Thr Pro Cys Ser
            420                 425                 430         
Pro Asp Ser Thr Ser Val Cys Val Gln Gly Gln Cys Val Lys Ala Gly

        435                 440                 445             
Cys Asp Arg Ile Ile Asp Ser Lys Lys Lys Phe Asp Lys Cys Gly Val
    450                 455                 460                 
Cys Gly Gly Asn Gly Ser Thr Cys Lys Lys Ile Ser Gly Ser Val Thr
465                 470                 475                 480 
Ser Ala Lys Pro Gly Tyr His Asp Ile Ile Thr Ile Pro Thr Gly Ala
                485                 490                 495     
Thr Asn Ile Glu Val Lys Gln Arg Asn Gln Arg Gly Ser Arg Asn Asn
            500                 505                 510         
Gly Ser Phe Leu Ala Ile Lys Ala Ala Asp Gly Thr Tyr Ile Leu Asn
        515                 520                 525             
Gly Asp Tyr Thr Leu Ser Thr Leu Glu Gln Asp Ile Met Tyr Lys Gly
    530                 535                 540                 
Val Val Leu Arg Tyr Ser Gly Ser Ser Ala Ala Leu Glu Arg Ile Arg
545                 550                 555                 560 
Ser Phe Ser Pro Leu Lys Glu Pro Leu Thr Ile Gln Val Leu Thr Val
                565                 570                 575     
Gly Asn Ala Leu Arg Pro Lys Ile Lys Tyr Thr Tyr Phe Val Lys Lys
            580                 585                 590         
Lys Lys Glu Ser Phe Asn Ala Ile Pro Thr Phe Ser Ala Trp Val Ile
        595                 600                 605             
Glu Glu Trp Gly Glu Cys Ser Lys Ser Cys Glu Leu Gly Trp Gln Arg
    610                 615                 620                 
Arg Leu Val Glu Cys Arg Asp Ile Asn Gly Gln Pro Ala Ser Glu Cys
625                 630                 635                 640 
Ala Lys Glu Val Lys Pro Ala Ser Thr Arg Pro Cys Ala Asp His Pro
                645                 650                 655     
Cys Pro Gln Trp Gln Leu Gly Glu Trp Ser Ser Cys Ser Lys Thr Cys
            660                 665                 670         
Gly Lys Gly Tyr Lys Lys Arg Ser Leu Lys Cys Leu Ser His Asp Gly
        675                 680                 685             
Gly Val Leu Ser His Glu Ser Cys Asp Pro Leu Lys Lys Pro Lys His
    690                 695                 700                 
Phe Ile Asp Phe Cys Thr Met Ala Glu Cys Ser
705                 710                 715 


<210> 160
<211> 3636
<212> DNA
<213> Homo sapiens

<220> 
<223> ADAMTS-2

<400> 160
atggatccgc cggcgggagc cgctcgccgc ctgctctgcc ccgcgctgct gctgctgctg 60
ctgctgctgc cgccgccgct cctgccgccg ccgccgccgc ccgcgaacgc caggctcgcc 120
gccgccgccg accccccagg cgggcccctg gggcacggag cggagcgcat cctggcggtg 180
cccgtgcgca ctgacgccca gggccgcttg gtgtcccacg tggtgtcggc agctacgtcc 240
agagcagggg tacgagcccg cagggccgcc ccggtccgga ccccgagctt ccccggaggc 300
aacgaggagg agcctggcag tcacctcttc tacaatgtca cggtctttgg ccgagacctg 360
cacctgcggc tgcggcccaa cgcccgcctc gtggcgcccg gggccactat ggagtggcag 420
ggcgagaagg gcaccacccg cgtggagccc ctgctcggga gctgtctcta cgtcggagac 480
gtggccggcc tagccgaagc ctcctctgtg gcgctcagca actgcgatgg gctggctggt 540
ctgatccgga tggaggagga ggagttcttc atcgaaccct tggagaaggg gctggcggcg 600
caggaggctg agcaaggccg tgtgcatgtg gtgtatcgcc ggccacccac gtcccctcct 660
ctcggggggc cacaggccct ggacacaggg gcctccctgg acagcctgga cagcctcagc 720
cgcgccctgg gcgtcctaga ggagcacgcc aacagctcga ggcggagggc acgcaggcat 780
gctgcagacg atgactacaa catcgaggtc ctgctgggcg tggatgactc tgtggtgcag 840
ttccacggga aggagcacgt acagaagtac ctgctgacac tcatgaacat tgtcaatgaa 900
atctaccatg acgagtcctt gggtgcccac atcaacgtgg tcctggtgcg gatcatcctc 960
ctgagctatg gaaagtccat gagcctcatc gagatcggga acccctctca gagcctggag 1020
aatgtctgcc gctgggccta cctccagcag aagccagaca cgggccacga tgaataccac 1080
gatcacgcca tcttcctcac acggcaggac tttgggcctt ccggcatgca aggctatgct 1140
cctgtcaccg gcatgtgcca tccggtccgc agctgcaccc tgaaccatga ggacggcttc 1200
tcctcagcgt ttgtggtggc ccatgagact ggccacgtgc tgggcatgga gcacgacggg 1260
cagggcaacc gctgtggcga cgaggtgcgg ctgggcagca tcatggcgcc cctggtgcag 1320
gccgccttcc accgcttcca ctggtcccgc tgcagccagc aggagctgag ccgctacctg 1380
cactcctatg actgcctgct ggatgacccc ttcgcccacg actggccggc gctgccccag 1440
ctcccgggac tgcactactc catgaacgag caatgccgct ttgacttcgg cctgggctac 1500
atgatgtgca cggcgttccg gacctttgac ccctgcaagc agctgtggtg cagccatcct 1560
gacaacccct acttttgcaa gaccaagaag gggcccccct tggacgggac tatgtgtgca 1620
cctggcaagc attgttttaa aggacactgc atctggctga cacctgacat cctcaaacgg 1680
gacggcagct ggggcgcttg gagtccgttt ggctcctgct cacgtacctg tggcacgggc 1740
gtgaagttca ggacccgcca gtgtgacaac ccacacccgg ccaacggggg ccgcacctgc 1800
tcgggccttg cctacgactt ccagctctgc agccgccagg actgccccga ctccctggct 1860
gacttccgcg aggagcagtg ccgccagtgg gacctgtact tcgagcacgg cgacgcccag 1920
caccactggc tgccccacga gcaccgggat gccaaggaga gatgccacct gtactgcgag 1980
tccagggaga ccggggaggt ggtgtccatg aagcgcatgg tgcatgatgg gacgcgctgc 2040
tcctacaagg acgccttcag cctctgtgtg cgcggggact gcaggaaggt gggctgtgac 2100
ggtgtgatcg gctccagcaa gcaggaagac aagtgtggcg tgtgcggagg ggacaacagc 2160
cactgcaaag tggtcaaggg cacgttcaca cggtcaccca agaagcatgg ttacatcaag 2220
atgtttgaga tccctgcagg agccagacac ctgctcattc aggaggtaga cgccaccagc 2280
caccatctgg ccgtcaagaa cctggagaca ggcaagttca tcttaaatga agagaatgac 2340
gtggatgcca gttccaaaac cttcattgcc atgggcgtgg agtgggagta cagagacgag 2400
gacggccggg agacgctgca gaccatgggc cccctccacg gcaccatcac cgttctggtc 2460
atcccggtgg gagacacccg ggtctcactg acgtacaaat acatgatcca tgaggactca 2520
ctgaatgtcg atgacaacaa cgtcctggaa gaggactctg tggtctacga gtgggccctg 2580
aagaagtggt ctccgtgctc caagccctgt ggcggagggt cccagttcac caagtatggc 2640
tgccgccgga ggctggacca caagatggta caccgtggct tctgtgccgc cctctcgaag 2700
cccaaagcca tccgcagagc gtgcaaccca caggaatgct cccagccagt gtgggtcaca 2760
ggcgaatggg agccatgtag ccagacctgt gggcggacag gcatgcaggt gcgctccgtg 2820
cgctgcattc agccgctaca cgacaacacc acccgctccg tgcacgccaa gcactgcaat 2880
gacgcccggc ccgagagccg ccgggcctgc agccgcgagc tctgccctgg tcgttggcga 2940
gccgggccct ggtcccagtg ctcagtaacc tgtggcaacg gcacccagga gcggccagtg 3000
ccctgccgca ccgcggacga cagcttcggc atctgccagg aggagcgtcc tgagacagcg 3060
aggacctgca ggcttggccc ctgtccccga aacatctcag atccctccaa gaagagctac 3120
gtagttcagt ggctgtcccg cccggacccc gactcgccca tccggaagat ctcgtcaaag 3180
ggccactgcc aaggcgacaa gtcaatattc tgtaggatgg aagtcttgtc ccgctattgc 3240
tccatcccag gctacaacaa gctgtcctgc aagtcctgta acctgtacaa caacctcacc 3300
aacgtggagg gcaggataga gccaccgcct gggaagcaca acgacattga cgtgttcatg 3360
cctaccctcc cagtgcccac tgtagccatg gaggtgcggc catcaccaag cacccccctg 3420
gaggtccctc tcaatgcctc cagcaccaat gccacagagg atcacccaga aaccaatgcc 3480
gtagatgaac cctacaaaat ccatggcctg gaagatgaag tccagccacc caacctaatc 3540
cctcgacgac cgagccccta tgaaaagacc agaaaccaaa gaatccaaga gctcattgat 3600
gagatgcgga agaaagagat gctcggaaag ttctaa                           3636

<210> 161
<211> 1211
<212> PRT
<213> Homo sapiens

<220> 
<223> ADAMTS-2 precursor

<400> 161
Met Asp Pro Pro Ala Gly Ala Ala Arg Arg Leu Leu Cys Pro Ala Leu
 1               5                  10                  15      
Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Leu Leu Pro Pro Pro Pro
            20                  25                  30          
Pro Pro Ala Asn Ala Arg Leu Ala Ala Ala Ala Asp Pro Pro Gly Gly
        35                  40                  45              
Pro Leu Gly His Gly Ala Glu Arg Ile Leu Ala Val Pro Val Arg Thr
    50                  55                  60                  
Asp Ala Gln Gly Arg Leu Val Ser His Val Val Ser Ala Ala Thr Ser
65                  70                  75                  80  
Arg Ala Gly Val Arg Ala Arg Arg Ala Ala Pro Val Arg Thr Pro Ser
                85                  90                  95      
Phe Pro Gly Gly Asn Glu Glu Glu Pro Gly Ser His Leu Phe Tyr Asn
            100                 105                 110         
Val Thr Val Phe Gly Arg Asp Leu His Leu Arg Leu Arg Pro Asn Ala
        115                 120                 125             
Arg Leu Val Ala Pro Gly Ala Thr Met Glu Trp Gln Gly Glu Lys Gly
    130                 135                 140                 
Thr Thr Arg Val Glu Pro Leu Leu Gly Ser Cys Leu Tyr Val Gly Asp
145                 150                 155                 160 
Val Ala Gly Leu Ala Glu Ala Ser Ser Val Ala Leu Ser Asn Cys Asp
                165                 170                 175     
Gly Leu Ala Gly Leu Ile Arg Met Glu Glu Glu Glu Phe Phe Ile Glu
            180                 185                 190         
Pro Leu Glu Lys Gly Leu Ala Ala Gln Glu Ala Glu Gln Gly Arg Val
        195                 200                 205             
His Val Val Tyr Arg Arg Pro Pro Thr Ser Pro Pro Leu Gly Gly Pro
    210                 215                 220                 
Gln Ala Leu Asp Thr Gly Ala Ser Leu Asp Ser Leu Asp Ser Leu Ser
225                 230                 235                 240 
Arg Ala Leu Gly Val Leu Glu Glu His Ala Asn Ser Ser Arg Arg Arg
                245                 250                 255     
Ala Arg Arg His Ala Ala Asp Asp Asp Tyr Asn Ile Glu Val Leu Leu
            260                 265                 270         
Gly Val Asp Asp Ser Val Val Gln Phe His Gly Lys Glu His Val Gln
        275                 280                 285             
Lys Tyr Leu Leu Thr Leu Met Asn Ile Val Asn Glu Ile Tyr His Asp
    290                 295                 300                 
Glu Ser Leu Gly Ala His Ile Asn Val Val Leu Val Arg Ile Ile Leu
305                 310                 315                 320 
Leu Ser Tyr Gly Lys Ser Met Ser Leu Ile Glu Ile Gly Asn Pro Ser
                325                 330                 335     
Gln Ser Leu Glu Asn Val Cys Arg Trp Ala Tyr Leu Gln Gln Lys Pro
            340                 345                 350         
Asp Thr Gly His Asp Glu Tyr His Asp His Ala Ile Phe Leu Thr Arg
        355                 360                 365             
Gln Asp Phe Gly Pro Ser Gly Met Gln Gly Tyr Ala Pro Val Thr Gly
    370                 375                 380                 
Met Cys His Pro Val Arg Ser Cys Thr Leu Asn His Glu Asp Gly Phe
385                 390                 395                 400 
Ser Ser Ala Phe Val Val Ala His Glu Thr Gly His Val Leu Gly Met
                405                 410                 415     
Glu His Asp Gly Gln Gly Asn Arg Cys Gly Asp Glu Val Arg Leu Gly
            420                 425                 430         
Ser Ile Met Ala Pro Leu Val Gln Ala Ala Phe His Arg Phe His Trp
        435                 440                 445             
Ser Arg Cys Ser Gln Gln Glu Leu Ser Arg Tyr Leu His Ser Tyr Asp
    450                 455                 460                 
Cys Leu Leu Asp Asp Pro Phe Ala His Asp Trp Pro Ala Leu Pro Gln
465                 470                 475                 480 
Leu Pro Gly Leu His Tyr Ser Met Asn Glu Gln Cys Arg Phe Asp Phe
                485                 490                 495     
Gly Leu Gly Tyr Met Met Cys Thr Ala Phe Arg Thr Phe Asp Pro Cys
            500                 505                 510         
Lys Gln Leu Trp Cys Ser His Pro Asp Asn Pro Tyr Phe Cys Lys Thr
        515                 520                 525             
Lys Lys Gly Pro Pro Leu Asp Gly Thr Met Cys Ala Pro Gly Lys His
    530                 535                 540                 
Cys Phe Lys Gly His Cys Ile Trp Leu Thr Pro Asp Ile Leu Lys Arg
545                 550                 555                 560 
Asp Gly Ser Trp Gly Ala Trp Ser Pro Phe Gly Ser Cys Ser Arg Thr
                565                 570                 575     
Cys Gly Thr Gly Val Lys Phe Arg Thr Arg Gln Cys Asp Asn Pro His
            580                 585                 590         
Pro Ala Asn Gly Gly Arg Thr Cys Ser Gly Leu Ala Tyr Asp Phe Gln
        595                 600                 605             
Leu Cys Ser Arg Gln Asp Cys Pro Asp Ser Leu Ala Asp Phe Arg Glu
    610                 615                 620                 
Glu Gln Cys Arg Gln Trp Asp Leu Tyr Phe Glu His Gly Asp Ala Gln
625                 630                 635                 640 
His His Trp Leu Pro His Glu His Arg Asp Ala Lys Glu Arg Cys His
                645                 650                 655     
Leu Tyr Cys Glu Ser Arg Glu Thr Gly Glu Val Val Ser Met Lys Arg
            660                 665                 670         
Met Val His Asp Gly Thr Arg Cys Ser Tyr Lys Asp Ala Phe Ser Leu
        675                 680                 685             
Cys Val Arg Gly Asp Cys Arg Lys Val Gly Cys Asp Gly Val Ile Gly
    690                 695                 700                 
Ser Ser Lys Gln Glu Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser
705                 710                 715                 720 
His Cys Lys Val Val Lys Gly Thr Phe Thr Arg Ser Pro Lys Lys His
                725                 730                 735     
Gly Tyr Ile Lys Met Phe Glu Ile Pro Ala Gly Ala Arg His Leu Leu
            740                 745                 750         
Ile Gln Glu Val Asp Ala Thr Ser His His Leu Ala Val Lys Asn Leu
        755                 760                 765             
Glu Thr Gly Lys Phe Ile Leu Asn Glu Glu Asn Asp Val Asp Ala Ser
    770                 775                 780                 
Ser Lys Thr Phe Ile Ala Met Gly Val Glu Trp Glu Tyr Arg Asp Glu
785                 790                 795                 800 
Asp Gly Arg Glu Thr Leu Gln Thr Met Gly Pro Leu His Gly Thr Ile
                805                 810                 815     
Thr Val Leu Val Ile Pro Val Gly Asp Thr Arg Val Ser Leu Thr Tyr
            820                 825                 830         
Lys Tyr Met Ile His Glu Asp Ser Leu Asn Val Asp Asp Asn Asn Val
        835                 840                 845             
Leu Glu Glu Asp Ser Val Val Tyr Glu Trp Ala Leu Lys Lys Trp Ser
    850                 855                 860                 
Pro Cys Ser Lys Pro Cys Gly Gly Gly Ser Gln Phe Thr Lys Tyr Gly
865                 870                 875                 880 
Cys Arg Arg Arg Leu Asp His Lys Met Val His Arg Gly Phe Cys Ala
                885                 890                 895     
Ala Leu Ser Lys Pro Lys Ala Ile Arg Arg Ala Cys Asn Pro Gln Glu
            900                 905                 910         
Cys Ser Gln Pro Val Trp Val Thr Gly Glu Trp Glu Pro Cys Ser Gln
        915                 920                 925             
Thr Cys Gly Arg Thr Gly Met Gln Val Arg Ser Val Arg Cys Ile Gln
    930                 935                 940                 
Pro Leu His Asp Asn Thr Thr Arg Ser Val His Ala Lys His Cys Asn
945                 950                 955                 960 
Asp Ala Arg Pro Glu Ser Arg Arg Ala Cys Ser Arg Glu Leu Cys Pro
                965                 970                 975     
Gly Arg Trp Arg Ala Gly Pro Trp Ser Gln Cys Ser Val Thr Cys Gly
            980                 985                 990         
Asn Gly Thr Gln Glu Arg Pro Val Pro Cys Arg Thr Ala Asp Asp Ser
        995                 1000                1005            
Phe Gly Ile Cys Gln Glu Glu Arg Pro Glu Thr Ala Arg Thr Cys Arg
    1010                1015                1020                
Leu Gly Pro Cys Pro Arg Asn Ile Ser Asp Pro Ser Lys Lys Ser Tyr
1025                1030                1035                1040
Val Val Gln Trp Leu Ser Arg Pro Asp Pro Asp Ser Pro Ile Arg Lys
                1045                1050                1055    
Ile Ser Ser Lys Gly His Cys Gln Gly Asp Lys Ser Ile Phe Cys Arg
            1060                1065                1070        
Met Glu Val Leu Ser Arg Tyr Cys Ser Ile Pro Gly Tyr Asn Lys Leu
        1075                1080                1085            
Ser Cys Lys Ser Cys Asn Leu Tyr Asn Asn Leu Thr Asn Val Glu Gly
    1090                1095                1100                
Arg Ile Glu Pro Pro Pro Gly Lys His Asn Asp Ile Asp Val Phe Met
1105                1110                1115                1120
Pro Thr Leu Pro Val Pro Thr Val Ala Met Glu Val Arg Pro Ser Pro
                1125                1130                1135    
Ser Thr Pro Leu Glu Val Pro Leu Asn Ala Ser Ser Thr Asn Ala Thr
            1140                1145                1150        
Glu Asp His Pro Glu Thr Asn Ala Val Asp Glu Pro Tyr Lys Ile His
        1155                1160                1165            
Gly Leu Glu Asp Glu Val Gln Pro Pro Asn Leu Ile Pro Arg Arg Pro
    1170                1175                1180                
Ser Pro Tyr Glu Lys Thr Arg Asn Gln Arg Ile Gln Glu Leu Ile Asp
1185                1190                1195                1200
Glu Met Arg Lys Lys Glu Met Leu Gly Lys Phe
                1205                1210    


<210> 162
<211> 958
<212> PRT
<213> Homo sapiens

<220> 
<223> ADAMTS-2 mature

<400> 162
Arg Arg Arg Ala Arg Arg His Ala Ala Asp Asp Asp Tyr Asn Ile Glu
 1               5                  10                  15      
Val Leu Leu Gly Val Asp Asp Ser Val Val Gln Phe His Gly Lys Glu
            20                  25                  30          
His Val Gln Lys Tyr Leu Leu Thr Leu Met Asn Ile Val Asn Glu Ile
        35                  40                  45              
Tyr His Asp Glu Ser Leu Gly Ala His Ile Asn Val Val Leu Val Arg
    50                  55                  60                  
Ile Ile Leu Leu Ser Tyr Gly Lys Ser Met Ser Leu Ile Glu Ile Gly
65                  70                  75                  80  
Asn Pro Ser Gln Ser Leu Glu Asn Val Cys Arg Trp Ala Tyr Leu Gln
                85                  90                  95      
Gln Lys Pro Asp Thr Gly His Asp Glu Tyr His Asp His Ala Ile Phe
            100                 105                 110         
Leu Thr Arg Gln Asp Phe Gly Pro Ser Gly Met Gln Gly Tyr Ala Pro
        115                 120                 125             
Val Thr Gly Met Cys His Pro Val Arg Ser Cys Thr Leu Asn His Glu
    130                 135                 140                 
Asp Gly Phe Ser Ser Ala Phe Val Val Ala His Glu Thr Gly His Val
145                 150                 155                 160 
Leu Gly Met Glu His Asp Gly Gln Gly Asn Arg Cys Gly Asp Glu Val
                165                 170                 175     
Arg Leu Gly Ser Ile Met Ala Pro Leu Val Gln Ala Ala Phe His Arg
            180                 185                 190         
Phe His Trp Ser Arg Cys Ser Gln Gln Glu Leu Ser Arg Tyr Leu His
        195                 200                 205             
Ser Tyr Asp Cys Leu Leu Asp Asp Pro Phe Ala His Asp Trp Pro Ala
    210                 215                 220                 
Leu Pro Gln Leu Pro Gly Leu His Tyr Ser Met Asn Glu Gln Cys Arg
225                 230                 235                 240 
Phe Asp Phe Gly Leu Gly Tyr Met Met Cys Thr Ala Phe Arg Thr Phe
                245                 250                 255     
Asp Pro Cys Lys Gln Leu Trp Cys Ser His Pro Asp Asn Pro Tyr Phe
            260                 265                 270         
Cys Lys Thr Lys Lys Gly Pro Pro Leu Asp Gly Thr Met Cys Ala Pro
        275                 280                 285             
Gly Lys His Cys Phe Lys Gly His Cys Ile Trp Leu Thr Pro Asp Ile
    290                 295                 300                 
Leu Lys Arg Asp Gly Ser Trp Gly Ala Trp Ser Pro Phe Gly Ser Cys
305                 310                 315                 320 
Ser Arg Thr Cys Gly Thr Gly Val Lys Phe Arg Thr Arg Gln Cys Asp
                325                 330                 335     
Asn Pro His Pro Ala Asn Gly Gly Arg Thr Cys Ser Gly Leu Ala Tyr
            340                 345                 350         
Asp Phe Gln Leu Cys Ser Arg Gln Asp Cys Pro Asp Ser Leu Ala Asp
        355                 360                 365             
Phe Arg Glu Glu Gln Cys Arg Gln Trp Asp Leu Tyr Phe Glu His Gly
    370                 375                 380                 
Asp Ala Gln His His Trp Leu Pro His Glu His Arg Asp Ala Lys Glu
385                 390                 395                 400 
Arg Cys His Leu Tyr Cys Glu Ser Arg Glu Thr Gly Glu Val Val Ser
                405                 410                 415     
Met Lys Arg Met Val His Asp Gly Thr Arg Cys Ser Tyr Lys Asp Ala
            420                 425                 430         
Phe Ser Leu Cys Val Arg Gly Asp Cys Arg Lys Val Gly Cys Asp Gly
        435                 440                 445             
Val Ile Gly Ser Ser Lys Gln Glu Asp Lys Cys Gly Val Cys Gly Gly
    450                 455                 460                 
Asp Asn Ser His Cys Lys Val Val Lys Gly Thr Phe Thr Arg Ser Pro
465                 470                 475                 480 
Lys Lys His Gly Tyr Ile Lys Met Phe Glu Ile Pro Ala Gly Ala Arg
                485                 490                 495     
His Leu Leu Ile Gln Glu Val Asp Ala Thr Ser His His Leu Ala Val
            500                 505                 510         
Lys Asn Leu Glu Thr Gly Lys Phe Ile Leu Asn Glu Glu Asn Asp Val
        515                 520                 525             
Asp Ala Ser Ser Lys Thr Phe Ile Ala Met Gly Val Glu Trp Glu Tyr
    530                 535                 540                 
Arg Asp Glu Asp Gly Arg Glu Thr Leu Gln Thr Met Gly Pro Leu His
545                 550                 555                 560 
Gly Thr Ile Thr Val Leu Val Ile Pro Val Gly Asp Thr Arg Val Ser
                565                 570                 575     
Leu Thr Tyr Lys Tyr Met Ile His Glu Asp Ser Leu Asn Val Asp Asp
            580                 585                 590         
Asn Asn Val Leu Glu Glu Asp Ser Val Val Tyr Glu Trp Ala Leu Lys
        595                 600                 605             
Lys Trp Ser Pro Cys Ser Lys Pro Cys Gly Gly Gly Ser Gln Phe Thr
    610                 615                 620                 
Lys Tyr Gly Cys Arg Arg Arg Leu Asp His Lys Met Val His Arg Gly
625                 630                 635                 640 
Phe Cys Ala Ala Leu Ser Lys Pro Lys Ala Ile Arg Arg Ala Cys Asn
                645                 650                 655     
Pro Gln Glu Cys Ser Gln Pro Val Trp Val Thr Gly Glu Trp Glu Pro
            660                 665                 670         
Cys Ser Gln Thr Cys Gly Arg Thr Gly Met Gln Val Arg Ser Val Arg
        675                 680                 685             
Cys Ile Gln Pro Leu His Asp Asn Thr Thr Arg Ser Val His Ala Lys
    690                 695                 700                 
His Cys Asn Asp Ala Arg Pro Glu Ser Arg Arg Ala Cys Ser Arg Glu
705                 710                 715                 720 
Leu Cys Pro Gly Arg Trp Arg Ala Gly Pro Trp Ser Gln Cys Ser Val
                725                 730                 735     
Thr Cys Gly Asn Gly Thr Gln Glu Arg Pro Val Pro Cys Arg Thr Ala
            740                 745                 750         
Asp Asp Ser Phe Gly Ile Cys Gln Glu Glu Arg Pro Glu Thr Ala Arg
        755                 760                 765             
Thr Cys Arg Leu Gly Pro Cys Pro Arg Asn Ile Ser Asp Pro Ser Lys
    770                 775                 780                 
Lys Ser Tyr Val Val Gln Trp Leu Ser Arg Pro Asp Pro Asp Ser Pro
785                 790                 795                 800 
Ile Arg Lys Ile Ser Ser Lys Gly His Cys Gln Gly Asp Lys Ser Ile
                805                 810                 815     
Phe Cys Arg Met Glu Val Leu Ser Arg Tyr Cys Ser Ile Pro Gly Tyr
            820                 825                 830         
Asn Lys Leu Ser Cys Lys Ser Cys Asn Leu Tyr Asn Asn Leu Thr Asn
        835                 840                 845             
Val Glu Gly Arg Ile Glu Pro Pro Pro Gly Lys His Asn Asp Ile Asp
    850                 855                 860                 
Val Phe Met Pro Thr Leu Pro Val Pro Thr Val Ala Met Glu Val Arg
865                 870                 875                 880 
Pro Ser Pro Ser Thr Pro Leu Glu Val Pro Leu Asn Ala Ser Ser Thr
                885                 890                 895     
Asn Ala Thr Glu Asp His Pro Glu Thr Asn Ala Val Asp Glu Pro Tyr
            900                 905                 910         
Lys Ile His Gly Leu Glu Asp Glu Val Gln Pro Pro Asn Leu Ile Pro
        915                 920                 925             
Arg Arg Pro Ser Pro Tyr Glu Lys Thr Arg Asn Gln Arg Ile Gln Glu
    930                 935                 940                 
Leu Ile Asp Glu Met Arg Lys Lys Glu Met Leu Gly Lys Phe
945                 950                 955             


<210> 163
<211> 5821
<212> DNA
<213> Homo sapiens

<220> 
<223> ADAMTS-3

<400> 163
gctttgccca gtagttggaa agtgaactcg actcgtgatg gttctcctgt cactttggtt 60
gatagcagcc gctctggtag aggttaggac ttcagctgat ggacaagctg gtaatgaaga 120
aatggtgcaa atagatttac caataaagag atatagagag tatgagctgg tgactccagt 180
cagcacaaat ctagaaggac gctatctctc ccatactctt tctgcgagtc acaaaaagag 240
gtcagcgagg gacgtgtctt ccaaccctga gcagttgttc tttaacatca cggcatttgg 300
aaaagatttt catctgcgac taaagcccaa cactcaacta gtagctcctg gggctgttgt 360
ggagtggcat gagacatctc tggtgcctgg gaatataacc gatcccatta acaaccatca 420
accaggaagt gctacgtata gaatccggaa aacagagcct ttgcagacta actgtgctta 480
tgttggtgac atcgtggaca ttccaggaac ctctgttgcc atcagcaact gtgatggtct 540
ggctggaatg ataaaaagtg ataatgaaga gtatttcatt gaacccttgg aaagaggtaa 600
acagatggag gaagaaaaag gaaggattca tgttgtctac aagagatcag ctgtagaaca 660
ggctcccata gacatgtcca aagacttcca ctacagagag tcggacctgg aaggccttga 720
tgatctaggt actgtttatg gcaacatcca ccagcagctg aatgaaacaa tgagacgccg 780
cagacacgcg ggagaaaacg attacaatat cgaggtactg ctgggagtgg atgactctgt 840
ggtccgtttc catggcaaag agcacgtcca aaactacctc ctgaccctaa tgaacattgt 900
gaatgaaatt taccatgatg agtccctcgg agtgcatata aatgtggtcc tggtgcgcat 960
gataatgctg ggatatgcaa agtccatcag cctcatagaa aggggaaacc catccagaag 1020
cttggagaat gtgtgtcgct gggcgtccca acagcaaaga tctgatctca accactctga 1080
acaccatgac catgcaattt ttttaaccag gcaagacttt ggacctgctg gaatgcaagg 1140
atatgctcca gtcaccggca tgtgtcatcc agtgagaagt tgtaccctga atcatgagga 1200
tggtttttca tctgcttttg tagtagccca tgaaacgggc catgtgttgg gaatggagca 1260
tgatggacaa ggcaacaggt gtggtgatga gactgctatg ggaagtgtca tggctccctt 1320
ggtacaagca gcattccatc gttaccactg gtcccgatgc agtggtcaag aactgaaaag 1380
atatatccat tcctatgact gtctccttga tgaccctttt gatcatgatt ggcctaaact 1440
cccagaactt cctggaatca attattctat ggatgagcaa tgtcgttttg attttggtgt 1500
tggctataaa atgtgcaccg cgttccgaac ctttgaccca tgtaaacagc tgtggtgtag 1560
ccatcctgat aatccctact tttgtaagac taaaaaggga cctccacttg atgggactga 1620
atgtgctgct ggaaaatggt gctataaggg tcattgcatg tggaagaatg ctaatcagca 1680
aaaacaagat ggcaattggg ggtcatggac taaatttggc tcctgttctc ggacatgtgg 1740
aactggtgtt cgtttcagaa cacgccagtg caataatccc atgcccatca atggtggtca 1800
ggattgtcct ggtgttaatt ttgagtacca gctttgtaac acagaagaat gccaaaaaca 1860
ctttgaggac ttcagagcac agcagtgtca gcagcgaaac tcccactttg aataccagaa 1920
taccaaacac cactggttgc catatgaaca tcctgacccc aagaaaagat gccaccttta 1980
ctgtcagtcc aaggagactg gagatgttgc ttacatgaaa caactggtgc atgatggaac 2040
gcactgttct tacaaagatc catatagcat atgtgtgcga ggagagtgtg tgaaagtggg 2100
ctgtgataaa gaaattggtt ctaataaggt tgaggataag tgtggtgtct gtggaggaga 2160
taattcccac tgccgaaccg tgaaggggac atttaccaga actcccagga agcttgggta 2220
ccttaagatg tttgatatac cccctggggc tagacatgtg ttaatccaag aagacgaggc 2280
ttctcctcat attcttgcta ttaagaacca ggctacaggc cattatattt taaatggcaa 2340
aggggaggaa gccaagtcgc ggaccttcat agatcttggt gtggagtggg attataacat 2400
tgaagatgac attgaaagtc ttcacaccga tggaccttta catgatcctg ttattgtttt 2460
gattatacct caagaaaatg atacccgctc tagcctgaca tataagtaca tcatccatga 2520
agactctgta cctacaatca acagcaacaa tgtcatccag gaagaattag atacttttga 2580
gtgggctttg aagagctggt ctcagtgttc caaaccctgt ggtggaggtt tccagtacac 2640
taaatatgga tgccgtagga aaagtgataa taaaatggtc catcgcagct tctgtgaggc 2700
caacaaaaag ccgaaaccta ttagacgaat gtgcaatatt caagagtgta cacatccact 2760
ctgggtagca gaagaatggg aacactgcac caaaacctgt ggaagttctg gctatcagct 2820
tcgcactgta cgctgccttc agccactcct tgatggcacc aaccgctctg tgcacagcaa 2880
atactgcatg ggtgaccgtc ccgagagccg ccggccctgt aacagagtgc cctgccctgc 2940
acagtggaaa acaggaccct ggagtgagtg ttcagtgacc tgcggtgaag gaacggaggt 3000
gaggcaggtc ctctgcaggg ctggggacca ctgtgatggt gaaaagcctg agtcggtcag 3060
agcctgtcaa ctgcctcctt gtaatgatga accatgtttg ggagacaagt ccatattctg 3120
tcaaatggaa gtgttggcac gatactgctc cataccaggt tataacaagt tatgttgtga 3180
gtcctgcagc aagcgcagta gcaccctgcc accaccatac cttctagaag ctgctgaaac 3240
tcatgatgat gtcatctcta accctagtga cctccctaga tctctagtga tgcctacatc 3300
tttggttcct tatcattcag agacccctgc aaagaagatg tctttgagta gcatctcttc 3360
agtgggaggt ccaaatgcat atgctgcttt caggccaaac agtaaacctg atggtgctaa 3420
tttacgccag aggagtgctc agcaagcagg aagtaagact gtgagactgg tcaccgtacc 3480
atcctcccca cccaccaaga gggtccacct cagttcagct tcacaaatgg ctgctgcttc 3540
cttctttgca gccagtgatt caataggtgc ttcttctcag gcaagaacct caaagaaaga 3600
tggaaagatc attgacaaca gacgtccgac aagatcatcc accttagaaa gatgagaaag 3660
tgaaccaaaa aggctagaaa ccagaggaaa acctggacaa cctctctctt cccatggtgc 3720
atatgcttgt ttaaagtgga aatctctata gatcgtcagc tcattttatc tgtaattgga 3780
agaacagaaa gtgctggctc actttctagt tgctttcatc ctccttttgt tctgcattga 3840
ctcatttacc agaattcatt ggaagaaatc accaaagatt attacaaaag aaaaatatgt 3900
tgctaagatt gtgttggtcg ctctctgaag cagaaaaggg actggaacca attgtgcata 3960
tcagctgact ttttgtttgt tttagaaaag ttacagtaaa aattaaaaag agataccaat 4020
ggtttacact ttaacaagaa attttggata tggaacaaag aattcttaga cttgtattcc 4080
tatttatcta tattagaaat attgtatgag caaatttgca gctgttgtgt aaatactgta 4140
tattgcaaaa atcagtatta ttttaagaga tgtgttctca aatgattgtt tactatatta 4200
catttctgga tgttctaggt gcctgtcgtt gagtattgcc ttgtttgaca ttctataggt 4260
taattttcaa agcagagtat tacaaaagag aagttagaat tacagctact gacaatataa 4320
agggttttgt tgaatcaaca atgtgatacg taaattatag aaaaagaaaa gaaacacaaa 4380
agctatagat atacagatat cagcttacct attgccttct atacttataa tttaaaggat 4440
tggtgtctta gtacacttgt ggtcacaggg atcaacgaat agtaaataat gaactcgtgc 4500
aagacaaaac tgaaaccctc tttccaggac ctcagtaggc accgttgagg tgtcctttgt 4560
ttttgtgtgt gtgtgttctt ttttaatttt cgcattgttg acagatacaa acagttatac 4620
tcaatgtact gtaataatcg caaaggaaaa agttttggga taacttattt gtatgttggt 4680
agctgagaaa aatatcatca gtctagaatt gatatttgag tatagtagag ctttggggct 4740
ttgaaggcag gttcaagaaa gcatatgtcg atggttgaga tatttatttt ccatatggtt 4800
catgttcaaa tgttcacaac cacaatgcat ctgactgcaa taatgtgcta ataatttatg 4860
tcagtagtca ccttgctcac agcaaagcca gaaatgctct ctccagggag tagatgtaaa 4920
gtacttgtac atagaattca gaactgaaga tatttattaa aagttgattt tttttcttga 4980
tagtattttt atgtactaaa tatttacact aatatcaatt acatattttg gtaaactaga 5040
gagacataat tagagatgca tgctttgttc tgtgcataga gacctttaag caaactacta 5100
cagccaactc aaaagctaaa actgaacaaa tttgatgtta tgcaaacatc ttgcattttt 5160
agtagttgat attaagttga tgacttgttt cccttcaagg aaacattaaa ttgtatggac 5220
tcagctagct gttcaatgaa attgtgaatt agaaacattt ttaaaagttt ttgaaagaga 5280
taagtgcatc atgaattaca tgtacatgag aggagatagt gatatcagca taatgatttt 5340
gaggtcagta cctgagctgt ctaaaaatat attatacaaa ctaaaatgta gatgaattaa 5400
cctctcaaag cacagaatgt gcaagaactt ttgcatttta atcgttgtaa actaacagct 5460
taaactattg actctatacc tctaaagaat tgctgctact ttgtgcaaga actttgaagg 5520
tcaaattagg caaattccag atagtaaaac aatccctaag ccttaagtct tttttttttc 5580
ctaaaaattc ccatagaata aaattctctc tagtttactt gtgtgtgcat acatctcatc 5640
cacaggggaa gataaagatg gtcacacaaa cagtttccat aaagatgtac atattcatta 5700
tacttctgac ctttgggctt tcttttctac taagctaaaa attccttttt atcaaagtgt 5760
acactactga tgctgtttgt tgtactgaga gcacgtacca ataaaaatgt taacaaaata 5820
t                                                                 5821



<210> 164
<211> 1205
<212> PRT
<213> Homo sapiens

<220> 
<223> ADAMTS-3 precursor

<400> 164
Met Val Leu Leu Ser Leu Trp Leu Ile Ala Ala Ala Leu Val Glu Val
 1               5                  10                  15      
Arg Thr Ser Ala Asp Gly Gln Ala Gly Asn Glu Glu Met Val Gln Ile
            20                  25                  30          
Asp Leu Pro Ile Lys Arg Tyr Arg Glu Tyr Glu Leu Val Thr Pro Val
        35                  40                  45              
Ser Thr Asn Leu Glu Gly Arg Tyr Leu Ser His Thr Leu Ser Ala Ser
    50                  55                  60                  
His Lys Lys Arg Ser Ala Arg Asp Val Ser Ser Asn Pro Glu Gln Leu
65                  70                  75                  80  
Phe Phe Asn Ile Thr Ala Phe Gly Lys Asp Phe His Leu Arg Leu Lys
                85                  90                  95      
Pro Asn Thr Gln Leu Val Ala Pro Gly Ala Val Val Glu Trp His Glu
            100                 105                 110         
Thr Ser Leu Val Pro Gly Asn Ile Thr Asp Pro Ile Asn Asn His Gln
        115                 120                 125             
Pro Gly Ser Ala Thr Tyr Arg Ile Arg Lys Thr Glu Pro Leu Gln Thr
    130                 135                 140                 
Asn Cys Ala Tyr Val Gly Asp Ile Val Asp Ile Pro Gly Thr Ser Val
145                 150                 155                 160 
Ala Ile Ser Asn Cys Asp Gly Leu Ala Gly Met Ile Lys Ser Asp Asn
                165                 170                 175     
Glu Glu Tyr Phe Ile Glu Pro Leu Glu Arg Gly Lys Gln Met Glu Glu
            180                 185                 190         
Glu Lys Gly Arg Ile His Val Val Tyr Lys Arg Ser Ala Val Glu Gln
        195                 200                 205             
Ala Pro Ile Asp Met Ser Lys Asp Phe His Tyr Arg Glu Ser Asp Leu
    210                 215                 220                 
Glu Gly Leu Asp Asp Leu Gly Thr Val Tyr Gly Asn Ile His Gln Gln
225                 230                 235                 240 
Leu Asn Glu Thr Met Arg Arg Arg Arg His Ala Gly Glu Asn Asp Tyr
                245                 250                 255     
Asn Ile Glu Val Leu Leu Gly Val Asp Asp Ser Val Val Arg Phe His
            260                 265                 270         
Gly Lys Glu His Val Gln Asn Tyr Leu Leu Thr Leu Met Asn Ile Val
        275                 280                 285             
Asn Glu Ile Tyr His Asp Glu Ser Leu Gly Val His Ile Asn Val Val
    290                 295                 300                 
Leu Val Arg Met Ile Met Leu Gly Tyr Ala Lys Ser Ile Ser Leu Ile
305                 310                 315                 320 
Glu Arg Gly Asn Pro Ser Arg Ser Leu Glu Asn Val Cys Arg Trp Ala
                325                 330                 335     
Ser Gln Gln Gln Arg Ser Asp Leu Asn His Ser Glu His His Asp His
            340                 345                 350         
Ala Ile Phe Leu Thr Arg Gln Asp Phe Gly Pro Ala Gly Met Gln Gly
        355                 360                 365             
Tyr Ala Pro Val Thr Gly Met Cys His Pro Val Arg Ser Cys Thr Leu
    370                 375                 380                 
Asn His Glu Asp Gly Phe Ser Ser Ala Phe Val Val Ala His Glu Thr
385                 390                 395                 400 
Gly His Val Leu Gly Met Glu His Asp Gly Gln Gly Asn Arg Cys Gly
                405                 410                 415     
Asp Glu Thr Ala Met Gly Ser Val Met Ala Pro Leu Val Gln Ala Ala
            420                 425                 430         
Phe His Arg Tyr His Trp Ser Arg Cys Ser Gly Gln Glu Leu Lys Arg
        435                 440                 445             
Tyr Ile His Ser Tyr Asp Cys Leu Leu Asp Asp Pro Phe Asp His Asp
    450                 455                 460                 
Trp Pro Lys Leu Pro Glu Leu Pro Gly Ile Asn Tyr Ser Met Asp Glu
465                 470                 475                 480 
Gln Cys Arg Phe Asp Phe Gly Val Gly Tyr Lys Met Cys Thr Ala Phe
                485                 490                 495     
Arg Thr Phe Asp Pro Cys Lys Gln Leu Trp Cys Ser His Pro Asp Asn
            500                 505                 510         
Pro Tyr Phe Cys Lys Thr Lys Lys Gly Pro Pro Leu Asp Gly Thr Glu
        515                 520                 525             
Cys Ala Ala Gly Lys Trp Cys Tyr Lys Gly His Cys Met Trp Lys Asn
    530                 535                 540                 
Ala Asn Gln Gln Lys Gln Asp Gly Asn Trp Gly Ser Trp Thr Lys Phe
545                 550                 555                 560 
Gly Ser Cys Ser Arg Thr Cys Gly Thr Gly Val Arg Phe Arg Thr Arg
                565                 570                 575     
Gln Cys Asn Asn Pro Met Pro Ile Asn Gly Gly Gln Asp Cys Pro Gly
            580                 585                 590         
Val Asn Phe Glu Tyr Gln Leu Cys Asn Thr Glu Glu Cys Gln Lys His
        595                 600                 605             
Phe Glu Asp Phe Arg Ala Gln Gln Cys Gln Gln Arg Asn Ser His Phe
    610                 615                 620                 
Glu Tyr Gln Asn Thr Lys His His Trp Leu Pro Tyr Glu His Pro Asp
625                 630                 635                 640 
Pro Lys Lys Arg Cys His Leu Tyr Cys Gln Ser Lys Glu Thr Gly Asp
                645                 650                 655     
Val Ala Tyr Met Lys Gln Leu Val His Asp Gly Thr His Cys Ser Tyr
            660                 665                 670         
Lys Asp Pro Tyr Ser Ile Cys Val Arg Gly Glu Cys Val Lys Val Gly
        675                 680                 685             
Cys Asp Lys Glu Ile Gly Ser Asn Lys Val Glu Asp Lys Cys Gly Val
    690                 695                 700                 
Cys Gly Gly Asp Asn Ser His Cys Arg Thr Val Lys Gly Thr Phe Thr
705                 710                 715                 720 
Arg Thr Pro Arg Lys Leu Gly Tyr Leu Lys Met Phe Asp Ile Pro Pro
                725                 730                 735     
Gly Ala Arg His Val Leu Ile Gln Glu Asp Glu Ala Ser Pro His Ile
            740                 745                 750         
Leu Ala Ile Lys Asn Gln Ala Thr Gly His Tyr Ile Leu Asn Gly Lys
        755                 760                 765             
Gly Glu Glu Ala Lys Ser Arg Thr Phe Ile Asp Leu Gly Val Glu Trp
    770                 775                 780                 
Asp Tyr Asn Ile Glu Asp Asp Ile Glu Ser Leu His Thr Asp Gly Pro
785                 790                 795                 800 
Leu His Asp Pro Val Ile Val Leu Ile Ile Pro Gln Glu Asn Asp Thr
                805                 810                 815     
Arg Ser Ser Leu Thr Tyr Lys Tyr Ile Ile His Glu Asp Ser Val Pro
            820                 825                 830         
Thr Ile Asn Ser Asn Asn Val Ile Gln Glu Glu Leu Asp Thr Phe Glu
        835                 840                 845             
Trp Ala Leu Lys Ser Trp Ser Gln Val Ser Lys Pro Cys Gly Gly Gly
    850                 855                 860                 
Phe Gln Tyr Thr Lys Tyr Gly Cys Arg Arg Lys Ser Asp Asn Lys Met
865                 870                 875                 880 
Val His Arg Ser Phe Cys Glu Ala Asn Lys Lys Pro Lys Pro Ile Arg
                885                 890                 895     
Arg Met Cys Asn Ile Gln Glu Cys Thr His Pro Leu Trp Val Ala Glu
            900                 905                 910         
Glu Trp Glu His Cys Thr Lys Thr Cys Gly Ser Ser Gly Tyr Gln Leu
        915                 920                 925             
Arg Thr Val Arg Cys Leu Gln Pro Leu Leu Asp Gly Thr Asn Arg Ser
    930                 935                 940                 
Val His Ser Lys Tyr Cys Met Gly Asp Arg Pro Glu Ser Arg Arg Pro
945                 950                 955                 960 
Cys Asn Arg Val Pro Cys Pro Ala Gln Trp Lys Thr Gly Pro Trp Ser
                965                 970                 975     
Glu Cys Ser Val Thr Cys Gly Glu Gly Thr Glu Val Arg Gln Val Leu
            980                 985                 990         
Cys Arg Ala Gly Asp His Cys Asp Gly Glu Lys Pro Glu Ser Val Arg
        995                 1000                1005            
Ala Cys Gln Leu Pro Pro Cys Asn Asp Glu Pro Cys Leu Gly Asp Lys
    1010                1015                1020                
Ser Ile Phe Cys Gln Met Glu Val Leu Ala Arg Tyr Cys Ser Ile Pro
1025                1030                1035                1040
Gly Tyr Asn Lys Leu Cys Cys Glu Ser Cys Ser Lys Arg Ser Ser Thr
                1045                1050                1055    
Leu Pro Pro Pro Tyr Leu Leu Glu Ala Ala Glu Thr His Asp Asp Val
            1060                1065                1070        
Ile Ser Asn Pro Ser Asp Leu Pro Arg Ser Leu Val Met Pro Thr Ser
        1075                1080                1085            
Leu Val Pro Tyr His Ser Glu Thr Pro Ala Lys Lys Met Ser Leu Ser
    1090                1095                1100                
Ser Ile Ser Ser Val Gly Gly Pro Asn Ala Tyr Ala Ala Phe Arg Pro
1105                1110                1115                1120
Asn Ser Lys Pro Asp Gly Ala Asn Leu Arg Gln Arg Ser Ala Gln Gln
                1125                1130                1135    
Ala Gly Ser Lys Thr Val Arg Leu Val Thr Val Pro Ser Ser Pro Pro
            1140                1145                1150        
Thr Lys Arg Val His Leu Ser Ser Ala Ser Gln Met Ala Ala Ala Ser
        1155                1160                1165            
Phe Phe Ala Ala Ser Asp Ser Ile Gly Ala Ser Ser Gln Ala Arg Thr
    1170                1175                1180                
Ser Lys Lys Asp Gly Lys Ile Ile Asp Asn Arg Arg Pro Thr Arg Ser
1185                1190                1195                1200
Ser Thr Leu Glu Arg
                1205

<210> 165
<211> 4342
<212> DNA
<213> Homo sapiens

<220> 
<223> ADAMTS-4

<400> 165
gggagaaccc acagggagac ccacagacac atatgcacga gagagacaga ggaggaaaga 60
gacagagaca aaggcacagc ggaagaaggc agagacaggg caggcacaga agcggcccag 120
acagagtcct acagagggag aggccagaga agctgcagaa gacacaggca gggagagaca 180
aagatccagg aaaggagggc tcaggaggag agtttggaga agccagaccc ctgggcacct 240
ctcccaagcc caaggactaa gttttctcca tttcctttaa cggtcctcag cccttctgaa 300
aactttgcct ctgaccttgg caggagtcca agcccccagg ctacagagag gagctttcca 360
aagctagggt gtggaggact tggtgcccta gacggcctca gtccctccca gctgcagtac 420
cagtgccatg tcccagacag gctcgcatcc cgggaggggc ttggcagggc gctggctgtg 480
gggagcccaa ccctgcctcc tgctccccat tgtgccgctc tcctggctgg tgtggctgct 540
tctgctactg ctggcctctc tcctgccctc agcccggctg gccagccccc tcccccggga 600
ggaggagatc gtgtttccag agaagctcaa cggcagcgtc ctgcctggct cgggcgcccc 660
tgccaggctg ttgtgccgct tgcaggcctt tggggagacg ctgctactag agctggagca 720
ggactccggt gtgcaggtcg aggggctgac agtgcagtac ctgggccagg cgcctgagct 780
gctgggtgga gcagagcctg gcacctacct gactggcacc atcaatggag atccggagtc 840
ggtggcatct ctgcactggg atgggggagc cctgttaggc gtgttacaat atcggggggc 900
tgaactccac ctccagcccc tggagggagg cacccctaac tctgctgggg gacctggggc 960
tcacatccta cgccggaaga gtcctgccag cggtcaaggt cccatgtgca acgtcaaggc 1020
tcctcttgga agccccagcc ccagaccccg aagagccaag cgctttgctt cactgagtag 1080
atttgtggag acactggtgg tggcagatga caagatggcc gcattccacg gtgcggggct 1140
aaagcgctac ctgctaacag tgatggcagc agcagccaag gccttcaagc acccaagcat 1200
ccgcaatcct gtcagcttgg tggtgactcg gctagtgatc ctggggtcag gcgaggaggg 1260
gccccaagtg gggcccagtg ctgcccagac cctgcgcagc ttctgtgcct ggcagcgggg 1320
cctcaacacc cctgaggact cggaccctga ccactttgac acagccattc tgtttacccg 1380
tcaggacctg tgtggagtct ccacttgcga cacgctgggt atggctgatg tgggcaccgt 1440
ctgtgacccg gctcggagct gtgccattgt ggaggatgat gggctccagt cagccttcac 1500
tgctgctcat gaactgggtc atgtcttcaa catgctccat gacaactcca agccatgcat 1560
cagtttgaat gggcctttga gcacctctcg ccatgtcatg gcccctgtga tggctcatgt 1620
ggatcctgag gagccctggt ccccctgcag tgcccgcttc atcactgact tcctggacaa 1680
tggctatggg cactgtctct tagacaaacc agaggctcca ttgcatctgc ctgtgacttt 1740
ccctggcaag gactatgatg ctgaccgcca gtgccagctg accttcgggc ccgactcacg 1800
ccattgtcca cagctgccgc cgccctgtgc tgccctctgg tgctctggcc acctcaatgg 1860
ccatgccatg tgccagacca aacactcgcc ctgggccgat ggcacaccct gcgggcccgc 1920
acaggcctgc atgggtggtc gctgcctcca catggaccag ctccaggact tcaatattcc 1980
acaggctggt ggctggggtc cttggggacc atggggtgac tgctctcgga cctgtggggg 2040
tggtgtccag ttctcctccc gagactgcac gaggcctgtc ccccggaatg gtggcaagta 2100
ctgtgagggc cgccgtaccc gcttccgctc ctgcaacact gaggactgcc caactggctc 2160
agccctgacc ttccgcgagg agcagtgtgc tgcctacaac caccgcaccg acctcttcaa 2220
gagcttccca gggcccatgg actgggttcc tcgctacaca ggcgtggccc cccaggacca 2280
gtgcaaactc acctgccagg cccgggcact gggctactac tatgtgctgg agccacgggt 2340
ggtagatggg accccctgtt ccccggacag ctcctcggtc tgtgtccagg gccgatgcat 2400
ccatgctggc tgtgatcgca tcattggctc caagaagaag tttgacaagt gcatggtgtg 2460
cggaggggac ggttctggtt gcagcaagca gtcaggctcc ttcaggaaat tcaggtacgg 2520
atacaacaat gtggtcacta tccccgcggg ggccacccac attcttgtcc ggcagcaggg 2580
aaaccctggc caccggagca tctacttggc cctgaagctg ccagatggct cctatgccct 2640
caatggtgaa tacacgctga tgccctcccc cacagatgtg gtactgcctg gggcagtcag 2700
cttgcgctac agcggggcca ctgcagcctc agagacactg tcaggccatg ggccactggc 2760
ccagcctttg acactgcaag tcctagtggc tggcaacccc caggacacac gcctccgata 2820
cagcttcttc gtgccccggc cgaccccttc aacgccacgc cccactcccc aggactggct 2880
gcaccgaaga gcacagattc tggagatcct tcggcggcgc ccctgggcgg gcaggaaata 2940
acctcactat cccggctgcc ctttctgggc accggggcct cggacttagc tgggagaaag 3000
agagagcttc tgttgctgcc tcatgctaag actcagtggg gaggggctgt gggcgtgaga 3060
cctgcccctc ctctctgccc taatgcgcag gctggccctg ccctggtttc ctgccctggg 3120
aggcagtgat gggttagtgg atggaagggg ctgacagaca gccctccatc taaactgccc 3180
cctctgccct gcgggtcaca ggagggaggg ggaaggcagg gagggcctgg gccccagttg 3240
tatttattta gtatttattc acttttattt agcaccaggg aaggggacaa ggactagggt 3300
cctggggaac ctgacccctg acccctcata gccctcaccc tggggctagg aaatccaggg 3360
tggtggtgat aggtataagt ggtgtgtgta tgcgtgtgtg tgtgtgtgaa aatgtgtgtg 3420
tgcttatgta tgaggtacaa cctgttctgc tttcctcttc ctgaatttta ttttttggga 3480
aaagaaaagt caagggtagg gtgggccttc agggagtgag ggattatctt tttttttttt 3540
tctttctttc tttctttttt ttttttgaga cagaatctcg ctctgtcgcc caggctggag 3600
tgcaatggca caatctcggc tcactgcatc ctccgcctcc cgggttcaag tgattctcat 3660
gcctcagcct cctgagtagc tgggattaca ggctcctgcc accacgcccg gctaattttt 3720
gttttgtttt gtttggagac agagtctcgc tattgtcacc agggctggaa tgatttcagc 3780
tcactgcaac cttcgccacc tgggttccag caattctcct gcctcagcct cccgagtagc 3840
tgagattata ggcacctacc accacgcccg gctaattttt gtatttttag tagagacggg 3900
gtttcaccat gttggccagg ctggtctcga actcctgacc ttaggtgatc cactcgcctt 3960
catctcccaa agtgctggga ttacaggcgt gagccaccgt gcctggccac gcccaactaa 4020
tttttgtatt tttagtagag acagggtttc accatgttgg ccaggctgct cttgaactcc 4080
tgacctcagg taatcgacct gcctcggcct cccaaagtgc tgggattaca ggtgtgagcc 4140
accacgcccg gtacatattt tttaaattga attctactat ttatgtgatc cttttggagt 4200
cagacagatg tggttgcatc ctaactccat gtctctgagc attagatttc tcatttgcca 4260
ataataatac ctcccttaga agtttgttgt gaggattaaa taatgtaaat aaagaactag 4320
cataacactc aaaaaaaaaa aa                                          4342


<210> 166
<211> 4342
<212> DNA
<213> Homo sapiens

<220> 
<223> ADAMTS-4

<400> 166
gggagaaccc acagggagac ccacagacac atatgcacga gagagacaga ggaggaaaga 60
gacagagaca aaggcacagc ggaagaaggc agagacaggg caggcacaga agcggcccag 120
acagagtcct acagagggag aggccagaga agctgcagaa gacacaggca gggagagaca 180
aagatccagg aaaggagggc tcaggaggag agtttggaga agccagaccc ctgggcacct 240
ctcccaagcc caaggactaa gttttctcca tttcctttaa cggtcctcag cccttctgaa 300
aactttgcct ctgaccttgg caggagtcca agcccccagg ctacagagag gagctttcca 360
aagctagggt gtggaggact tggtgcccta gacggcctca gtccctccca gctgcagtac 420
cagtgccatg tcccagacag gctcgcatcc cgggaggggc ttggcagggc gctggctgtg 480
gggagcccaa ccctgcctcc tgctccccat tgtgccgctc tcctggctgg tgtggctgct 540
tctgctactg ctggcctctc tcctgccctc agcccggctg gccagccccc tcccccggga 600
ggaggagatc gtgtttccag agaagctcaa cggcagcgtc ctgcctggct cgggcgcccc 660
tgccaggctg ttgtgccgct tgcaggcctt tggggagacg ctgctactag agctggagca 720
ggactccggt gtgcaggtcg aggggctgac agtgcagtac ctgggccagg cgcctgagct 780
gctgggtgga gcagagcctg gcacctacct gactggcacc atcaatggag atccggagtc 840
ggtggcatct ctgcactggg atgggggagc cctgttaggc gtgttacaat atcggggggc 900
tgaactccac ctccagcccc tggagggagg cacccctaac tctgctgggg gacctggggc 960
tcacatccta cgccggaaga gtcctgccag cggtcaaggt cccatgtgca acgtcaaggc 1020
tcctcttgga agccccagcc ccagaccccg aagagccaag cgctttgctt cactgagtag 1080
atttgtggag acactggtgg tggcagatga caagatggcc gcattccacg gtgcggggct 1140
aaagcgctac ctgctaacag tgatggcagc agcagccaag gccttcaagc acccaagcat 1200
ccgcaatcct gtcagcttgg tggtgactcg gctagtgatc ctggggtcag gcgaggaggg 1260
gccccaagtg gggcccagtg ctgcccagac cctgcgcagc ttctgtgcct ggcagcgggg 1320
cctcaacacc cctgaggact cggaccctga ccactttgac acagccattc tgtttacccg 1380
tcaggacctg tgtggagtct ccacttgcga cacgctgggt atggctgatg tgggcaccgt 1440
ctgtgacccg gctcggagct gtgccattgt ggaggatgat gggctccagt cagccttcac 1500
tgctgctcat gaactgggtc atgtcttcaa catgctccat gacaactcca agccatgcat 1560
cagtttgaat gggcctttga gcacctctcg ccatgtcatg gcccctgtga tggctcatgt 1620
ggatcctgag gagccctggt ccccctgcag tgcccgcttc atcactgact tcctggacaa 1680
tggctatggg cactgtctct tagacaaacc agaggctcca ttgcatctgc ctgtgacttt 1740
ccctggcaag gactatgatg ctgaccgcca gtgccagctg accttcgggc ccgactcacg 1800
ccattgtcca cagctgccgc cgccctgtgc tgccctctgg tgctctggcc acctcaatgg 1860
ccatgccatg tgccagacca aacactcgcc ctgggccgat ggcacaccct gcgggcccgc 1920
acaggcctgc atgggtggtc gctgcctcca catggaccag ctccaggact tcaatattcc 1980
acaggctggt ggctggggtc cttggggacc atggggtgac tgctctcgga cctgtggggg 2040
tggtgtccag ttctcctccc gagactgcac gaggcctgtc ccccggaatg gtggcaagta 2100
ctgtgagggc cgccgtaccc gcttccgctc ctgcaacact gaggactgcc caactggctc 2160
agccctgacc ttccgcgagg agcagtgtgc tgcctacaac caccgcaccg acctcttcaa 2220
gagcttccca gggcccatgg actgggttcc tcgctacaca ggcgtggccc cccaggacca 2280
gtgcaaactc acctgccagg cccgggcact gggctactac tatgtgctgg agccacgggt 2340
ggtagatggg accccctgtt ccccggacag ctcctcggtc tgtgtccagg gccgatgcat 2400
ccatgctggc tgtgatcgca tcattggctc caagaagaag tttgacaagt gcatggtgtg 2460
cggaggggac ggttctggtt gcagcaagca gtcaggctcc ttcaggaaat tcaggtacgg 2520
atacaacaat gtggtcacta tccccgcggg ggccacccac attcttgtcc ggcagcaggg 2580
aaaccctggc caccggagca tctacttggc cctgaagctg ccagatggct cctatgccct 2640
caatggtgaa tacacgctga tgccctcccc cacagatgtg gtactgcctg gggcagtcag 2700
cttgcgctac agcggggcca ctgcagcctc agagacactg tcaggccatg ggccactggc 2760
ccagcctttg acactgcaag tcctagtggc tggcaacccc caggacacac gcctccgata 2820
cagcttcttc gtgccccggc cgaccccttc aacgccacgc cccactcccc aggactggct 2880
gcaccgaaga gcacagattc tggagatcct tcggcggcgc ccctgggcgg gcaggaaata 2940
acctcactat cccggctgcc ctttctgggc accggggcct cggacttagc tgggagaaag 3000
agagagcttc tgttgctgcc tcatgctaag actcagtggg gaggggctgt gggcgtgaga 3060
cctgcccctc ctctctgccc taatgcgcag gctggccctg ccctggtttc ctgccctggg 3120
aggcagtgat gggttagtgg atggaagggg ctgacagaca gccctccatc taaactgccc 3180
cctctgccct gcgggtcaca ggagggaggg ggaaggcagg gagggcctgg gccccagttg 3240
tatttattta gtatttattc acttttattt agcaccaggg aaggggacaa ggactagggt 3300
cctggggaac ctgacccctg acccctcata gccctcaccc tggggctagg aaatccaggg 3360
tggtggtgat aggtataagt ggtgtgtgta tgcgtgtgtg tgtgtgtgaa aatgtgtgtg 3420
tgcttatgta tgaggtacaa cctgttctgc tttcctcttc ctgaatttta ttttttggga 3480
aaagaaaagt caagggtagg gtgggccttc agggagtgag ggattatctt tttttttttt 3540
tctttctttc tttctttttt ttttttgaga cagaatctcg ctctgtcgcc caggctggag 3600
tgcaatggca caatctcggc tcactgcatc ctccgcctcc cgggttcaag tgattctcat 3660
gcctcagcct cctgagtagc tgggattaca ggctcctgcc accacgcccg gctaattttt 3720
gttttgtttt gtttggagac agagtctcgc tattgtcacc agggctggaa tgatttcagc 3780
tcactgcaac cttcgccacc tgggttccag caattctcct gcctcagcct cccgagtagc 3840
tgagattata ggcacctacc accacgcccg gctaattttt gtatttttag tagagacggg 3900
gtttcaccat gttggccagg ctggtctcga actcctgacc ttaggtgatc cactcgcctt 3960
catctcccaa agtgctggga ttacaggcgt gagccaccgt gcctggccac gcccaactaa 4020
tttttgtatt tttagtagag acagggtttc accatgttgg ccaggctgct cttgaactcc 4080
tgacctcagg taatcgacct gcctcggcct cccaaagtgc tgggattaca ggtgtgagcc 4140
accacgcccg gtacatattt tttaaattga attctactat ttatgtgatc cttttggagt 4200
cagacagatg tggttgcatc ctaactccat gtctctgagc attagatttc tcatttgcca 4260
ataataatac ctcccttaga agtttgttgt gaggattaaa taatgtaaat aaagaactag 4320
cataacactc aaaaaaaaaa aa                                          4342

<210> 167
<211> 837
<212> PRT
<213> Homo sapiens

<220> 
<223> ADAMTS-4  precursor

<400> 167
Met Ser Gln Thr Gly Ser His Pro Gly Arg Gly Leu Ala Gly Arg Trp
 1               5                  10                  15      
Leu Trp Gly Ala Gln Pro Cys Leu Leu Leu Pro Ile Val Pro Leu Ser
            20                  25                  30          
Trp Leu Val Trp Leu Leu Leu Leu Leu Leu Ala Ser Leu Leu Pro Ser
        35                  40                  45              
Ala Arg Leu Ala Ser Pro Leu Pro Arg Glu Glu Glu Ile Val Phe Pro
    50                  55                  60                  
Glu Lys Leu Asn Gly Ser Val Leu Pro Gly Ser Gly Ala Pro Ala Arg
65                  70                  75                  80  
Leu Leu Cys Arg Leu Gln Ala Phe Gly Glu Thr Leu Leu Leu Glu Leu
                85                  90                  95      
Glu Gln Asp Ser Gly Val Gln Val Glu Gly Leu Thr Val Gln Tyr Leu

            100                 105                 110         
Gly Gln Ala Pro Glu Leu Leu Gly Gly Ala Glu Pro Gly Thr Tyr Leu
        115                 120                 125             
Thr Gly Thr Ile Asn Gly Asp Pro Glu Ser Val Ala Ser Leu His Trp
    130                 135                 140                 
Asp Gly Gly Ala Leu Leu Gly Val Leu Gln Tyr Arg Gly Ala Glu Leu
145                 150                 155                 160 
His Leu Gln Pro Leu Glu Gly Gly Thr Pro Asn Ser Ala Gly Gly Pro
                165                 170                 175     
Gly Ala His Ile Leu Arg Arg Lys Ser Pro Ala Ser Gly Gln Gly Pro
            180                 185                 190         
Met Cys Asn Val Lys Ala Pro Leu Gly Ser Pro Ser Pro Arg Pro Arg
        195                 200                 205             
Arg Ala Lys Arg Phe Ala Ser Leu Ser Arg Phe Val Glu Thr Leu Val
    210                 215                 220                 
Val Ala Asp Asp Lys Met Ala Ala Phe His Gly Ala Gly Leu Lys Arg
225                 230                 235                 240 
Tyr Leu Leu Thr Val Met Ala Ala Ala Ala Lys Ala Phe Lys His Pro
                245                 250                 255     
Ser Ile Arg Asn Pro Val Ser Leu Val Val Thr Arg Leu Val Ile Leu
            260                 265                 270         
Gly Ser Gly Glu Glu Gly Pro Gln Val Gly Pro Ser Ala Ala Gln Thr
        275                 280                 285             
Leu Arg Ser Phe Cys Ala Trp Gln Arg Gly Leu Asn Thr Pro Glu Asp
    290                 295                 300                 
Ser Asp Pro Asp His Phe Asp Thr Ala Ile Leu Phe Thr Arg Gln Asp
305                 310                 315                 320 
Leu Cys Gly Val Ser Thr Cys Asp Thr Leu Gly Met Ala Asp Val Gly
                325                 330                 335     
Thr Val Cys Asp Pro Ala Arg Ser Cys Ala Ile Val Glu Asp Asp Gly
            340                 345                 350         
Leu Gln Ser Ala Phe Thr Ala Ala His Glu Leu Gly His Val Phe Asn
        355                 360                 365             
Met Leu His Asp Asn Ser Lys Pro Cys Ile Ser Leu Asn Gly Pro Leu
    370                 375                 380                 
Ser Thr Ser Arg His Val Met Ala Pro Val Met Ala His Val Asp Pro
385                 390                 395                 400 
Glu Glu Pro Trp Ser Pro Cys Ser Ala Arg Phe Ile Thr Asp Phe Leu
                405                 410                 415     
Asp Asn Gly Tyr Gly His Cys Leu Leu Asp Lys Pro Glu Ala Pro Leu
            420                 425                 430         
His Leu Pro Val Thr Phe Pro Gly Lys Asp Tyr Asp Ala Asp Arg Gln
        435                 440                 445             
Cys Gln Leu Thr Phe Gly Pro Asp Ser Arg His Cys Pro Gln Leu Pro
    450                 455                 460                 
Pro Pro Cys Ala Ala Leu Trp Cys Ser Gly His Leu Asn Gly His Ala
465                 470                 475                 480 
Met Cys Gln Thr Lys His Ser Pro Trp Ala Asp Gly Thr Pro Cys Gly
                485                 490                 495     
Pro Ala Gln Ala Cys Met Gly Gly Arg Cys Leu His Met Asp Gln Leu
            500                 505                 510         
Gln Asp Phe Asn Ile Pro Gln Ala Gly Gly Trp Gly Pro Trp Gly Pro
        515                 520                 525             
Trp Gly Asp Cys Ser Arg Thr Cys Gly Gly Gly Val Gln Phe Ser Ser
    530                 535                 540                 
Arg Asp Cys Thr Arg Pro Val Pro Arg Asn Gly Gly Lys Tyr Cys Glu
545                 550                 555                 560 
Gly Arg Arg Thr Arg Phe Arg Ser Cys Asn Thr Glu Asp Cys Pro Thr
                565                 570                 575     
Gly Ser Ala Leu Thr Phe Arg Glu Glu Gln Cys Ala Ala Tyr Asn His
            580                 585                 590         
Arg Thr Asp Leu Phe Lys Ser Phe Pro Gly Pro Met Asp Trp Val Pro
        595                 600                 605             
Arg Tyr Thr Gly Val Ala Pro Gln Asp Gln Cys Lys Leu Thr Cys Gln
    610                 615                 620                 
Ala Arg Ala Leu Gly Tyr Tyr Tyr Val Leu Glu Pro Arg Val Val Asp
625                 630                 635                 640 
Gly Thr Pro Cys Ser Pro Asp Ser Ser Ser Val Cys Val Gln Gly Arg
                645                 650                 655     
Cys Ile His Ala Gly Cys Asp Arg Ile Ile Gly Ser Lys Lys Lys Phe
            660                 665                 670         
Asp Lys Cys Met Val Cys Gly Gly Asp Gly Ser Gly Cys Ser Lys Gln
        675                 680                 685             
Ser Gly Ser Phe Arg Lys Phe Arg Tyr Gly Tyr Asn Asn Val Val Thr
    690                 695                 700                 
Ile Pro Ala Gly Ala Thr His Ile Leu Val Arg Gln Gln Gly Asn Pro
705                 710                 715                 720 
Gly His Arg Ser Ile Tyr Leu Ala Leu Lys Leu Pro Asp Gly Ser Tyr
                725                 730                 735     
Ala Leu Asn Gly Glu Tyr Thr Leu Met Pro Ser Pro Thr Asp Val Val
            740                 745                 750         
Leu Pro Gly Ala Val Ser Leu Arg Tyr Ser Gly Ala Thr Ala Ala Ser
        755                 760                 765             
Glu Thr Leu Ser Gly His Gly Pro Leu Ala Gln Pro Leu Thr Leu Gln
    770                 775                 780                 
Val Leu Val Ala Gly Asn Pro Gln Asp Thr Arg Leu Arg Tyr Ser Phe
785                 790                 795                 800 
Phe Val Pro Arg Pro Thr Pro Ser Thr Pro Arg Pro Thr Pro Gln Asp
                805                 810                 815     
Trp Leu His Arg Arg Ala Gln Ile Leu Glu Ile Leu Arg Arg Arg Pro
            820                 825                 830         
Trp Ala Gly Arg Lys
        835         


<210> 168
<211> 625
<212> PRT
<213> Homo sapiens

<220> 
<223> ADAMTS-4  mature

<400> 168
Phe Ala Ser Leu Ser Arg Phe Val Glu Thr Leu Val Val Ala Asp Asp
 1               5                  10                  15      
Lys Met Ala Ala Phe His Gly Ala Gly Leu Lys Arg Tyr Leu Leu Thr
            20                  25                  30          
Val Met Ala Ala Ala Ala Lys Ala Phe Lys His Pro Ser Ile Arg Asn
        35                  40                  45              
Pro Val Ser Leu Val Val Thr Arg Leu Val Ile Leu Gly Ser Gly Glu
    50                  55                  60                  
Glu Gly Pro Gln Val Gly Pro Ser Ala Ala Gln Thr Leu Arg Ser Phe
65                  70                  75                  80  
Cys Ala Trp Gln Arg Gly Leu Asn Thr Pro Glu Asp Ser Asp Pro Asp
                85                  90                  95      
His Phe Asp Thr Ala Ile Leu Phe Thr Arg Gln Asp Leu Cys Gly Val
            100                 105                 110         
Ser Thr Cys Asp Thr Leu Gly Met Ala Asp Val Gly Thr Val Cys Asp
        115                 120                 125             
Pro Ala Arg Ser Cys Ala Ile Val Glu Asp Asp Gly Leu Gln Ser Ala
    130                 135                 140                 
Phe Thr Ala Ala His Glu Leu Gly His Val Phe Asn Met Leu His Asp
145                 150                 155                 160 
Asn Ser Lys Pro Cys Ile Ser Leu Asn Gly Pro Leu Ser Thr Ser Arg
                165                 170                 175     
His Val Met Ala Pro Val Met Ala His Val Asp Pro Glu Glu Pro Trp
            180                 185                 190         

Ser Pro Cys Ser Ala Arg Phe Ile Thr Asp Phe Leu Asp Asn Gly Tyr
        195                 200                 205             
Gly His Cys Leu Leu Asp Lys Pro Glu Ala Pro Leu His Leu Pro Val
    210                 215                 220                 
Thr Phe Pro Gly Lys Asp Tyr Asp Ala Asp Arg Gln Cys Gln Leu Thr
225                 230                 235                 240 
Phe Gly Pro Asp Ser Arg His Cys Pro Gln Leu Pro Pro Pro Cys Ala
                245                 250                 255     
Ala Leu Trp Cys Ser Gly His Leu Asn Gly His Ala Met Cys Gln Thr
            260                 265                 270         
Lys His Ser Pro Trp Ala Asp Gly Thr Pro Cys Gly Pro Ala Gln Ala
        275                 280                 285             
Cys Met Gly Gly Arg Cys Leu His Met Asp Gln Leu Gln Asp Phe Asn
    290                 295                 300                 
Ile Pro Gln Ala Gly Gly Trp Gly Pro Trp Gly Pro Trp Gly Asp Cys
305                 310                 315                 320 
Ser Arg Thr Cys Gly Gly Gly Val Gln Phe Ser Ser Arg Asp Cys Thr
                325                 330                 335     
Arg Pro Val Pro Arg Asn Gly Gly Lys Tyr Cys Glu Gly Arg Arg Thr
            340                 345                 350         
Arg Phe Arg Ser Cys Asn Thr Glu Asp Cys Pro Thr Gly Ser Ala Leu
        355                 360                 365             
Thr Phe Arg Glu Glu Gln Cys Ala Ala Tyr Asn His Arg Thr Asp Leu
    370                 375                 380                 
Phe Lys Ser Phe Pro Gly Pro Met Asp Trp Val Pro Arg Tyr Thr Gly
385                 390                 395                 400 
Val Ala Pro Gln Asp Gln Cys Lys Leu Thr Cys Gln Ala Arg Ala Leu
                405                 410                 415     
Gly Tyr Tyr Tyr Val Leu Glu Pro Arg Val Val Asp Gly Thr Pro Cys
            420                 425                 430         
Ser Pro Asp Ser Ser Ser Val Cys Val Gln Gly Arg Cys Ile His Ala
        435                 440                 445             
Gly Cys Asp Arg Ile Ile Gly Ser Lys Lys Lys Phe Asp Lys Cys Met
    450                 455                 460                 
Val Cys Gly Gly Asp Gly Ser Gly Cys Ser Lys Gln Ser Gly Ser Phe
465                 470                 475                 480 
Arg Lys Phe Arg Tyr Gly Tyr Asn Asn Val Val Thr Ile Pro Ala Gly
                485                 490                 495     
Ala Thr His Ile Leu Val Arg Gln Gln Gly Asn Pro Gly His Arg Ser
            500                 505                 510         
Ile Tyr Leu Ala Leu Lys Leu Pro Asp Gly Ser Tyr Ala Leu Asn Gly
        515                 520                 525             
Glu Tyr Thr Leu Met Pro Ser Pro Thr Asp Val Val Leu Pro Gly Ala

    530                 535                 540                 
Val Ser Leu Arg Tyr Ser Gly Ala Thr Ala Ala Ser Glu Thr Leu Ser
545                 550                 555                 560 
Gly His Gly Pro Leu Ala Gln Pro Leu Thr Leu Gln Val Leu Val Ala
                565                 570                 575     
Gly Asn Pro Gln Asp Thr Arg Leu Arg Tyr Ser Phe Phe Val Pro Arg
            580                 585                 590         
Pro Thr Pro Ser Thr Pro Arg Pro Thr Pro Gln Asp Trp Leu His Arg
        595                 600                 605             
Arg Ala Gln Ile Leu Glu Ile Leu Arg Arg Arg Pro Trp Ala Gly Arg
    610                 615                 620                 
Lys
625 


<210> 169
<211> 9046
<212> DNA
<213> Homo sapiens

<220> 
<223> ADAMTS-5

<400> 169
cttgactcaa tcctgcaagc aagtgtgtgt gtgtccccat cccccgcccc gttaacttca 60
tagcaaataa caaataccca taaagtccca gtcgcgcagc ccctccccgc gggcagcgca 120
ctatgctgct cgggtgggcg tccctgctgc tgtgcgcgtt ccgcctgccc ctggccgcgg 180
tcggccccgc cgcgacacct gcccaggata aagccgggca gcctccgact gctgcagcag 240
ccgcccagcc ccgccggcgg cagggggagg aggtgcagga gcgagccgag cctcccggcc 300
acccgcaccc cctggcgcag cggcgcagga gcaaggggct ggtgcagaac atcgaccaac 360
tctactccgg cggcggcaag gtgggctacc tcgtctacgc gggcggccgg aggttcctct 420
tggacctgga gcgagatggt tcggtgggca ttgctggctt cgtgcccgca ggaggcggga 480
cgagtgcgcc ctggcgccac cggagccact gcttctatcg gggcacagtg gacgctagtc 540
cccgctctct ggctgtcttt gacctctgtg ggggtctcga cggcttcttc gcggtcaagc 600
acgcgcgcta caccctaaag ccactgctgc gcggaccctg ggcggaggaa gaaaaggggc 660
gcgtgtacgg ggatgggtcc gcacggatcc tgcacgtcta cacccgcgag ggcttcagct 720
tcgaggccct gccgccgcgc gccagctgcg aaacccccgc gtccacaccg gaggcccacg 780
agcatgctcc ggcgcacagc aacccgagcg gacgcgcagc actggcctcg cagctcttgg 840
accagtccgc tctctcgccc gctgggggct caggaccgca gacgtggtgg cggcggcggc 900
gccgctccat ctcccgggcc cgccaggtgg agctgcttct ggtggctgac gcgtccatgg 960
cgcggttgta tggccggggc ctgcagcatt acctgctgac cctggcctcc atcgccaata 1020
ggctgtacag ccatgctagc atcgagaacc acatccgcct ggccgtggtg aaggtggtgg 1080
tgctaggcga caaggacaag agcctggaag tgagcaagaa cgctgccacc acactcaaga 1140
acttttgcaa gtggcagcac caacacaacc agctgggaga tgaccatgag gagcactacg 1200
atgcagctat cctgtttact cgggaggatt tatgtgggca tcattcatgt gacaccctgg 1260
gaatggcaga cgttgggacc atatgttctc cagagcgcag ctgtgctgtg attgaagacg 1320
atggcctcca cgcagccttc actgtggctc acgaaatcgg acatttactt ggcctctccc 1380
atgacgattc caaattctgt gaagagacct ttggttccac agaagataag cgcttaatgt 1440
cttccatcct taccagcatt gatgcatcta agccctggtc caaatgcact tcagccacca 1500
tcacagaatt cctggatgat ggccatggta actgtttgct ggacctacca cgaaagcaga 1560
tcctgggccc cgaagaactc ccaggacaga cctacgatgc cacccagcag tgcaacctga 1620
cattcgggcc tgagtactcc gtgtgtcccg gcatggatgt ctgtgctcgc ctgtggtgtg 1680
ctgtggtacg ccagggccag atggtctgtc tgaccaagaa gctgcctgcg gtggaaggga 1740
cgccttgtgg aaaggggaga atctgcctgc agggcaaatg tgtggacaaa accaagaaaa 1800
aatattattc aacgtcaagc catggcaact ggggatcttg gggatcctgg ggccagtgtt 1860
ctcgctcatg tggaggagga gtgcagtttg cctatcgtca ctgtaataac cctgctccca 1920
gaaacaacgg acgctactgc acagggaaga gggccatcta ccgctcctgc agtctcatgc 1980
cctgcccacc caatggtaaa tcatttcgtc atgaacagtg tgaggccaaa aatggctatc 2040
agtctgatgc aaaaggagtc aaaacttttg tggaatgggt tcccaaatat gcaggtgtcc 2100
tgccagcgga tgtgtgcaag ctgacctgca gagccaaggg cactggctac tatgtggtat 2160
tttctccaaa ggtgaccgat ggcactgaat gtaggccgta cagtaattcc gtctgcgtcc 2220
gggggaagtg tgtgagaact ggctgtgacg gcatcattgg ctcaaagctg cagtatgaca 2280
agtgcggagt atgtggagga gacaactcca gctgtacaaa gattgttgga acctttaata 2340
agaaaagtaa gggttacact gacgtggtga ggattcctga aggggcaacc cacataaaag 2400
ttcgacagtt caaagccaaa gaccagacta gattcactgc ctatttagcc ctgaaaaaga 2460
aaaacggtga gtaccttatc aatggaaagt acatgatctc cacttcagag actatcattg 2520
acatcaatgg aacagtcatg aactatagcg gttggagcca cagggatgac ttcctgcatg 2580
gcatgggcta ctctgccacg aaggaaattc taatagtgca gattcttgca acagacccca 2640
ctaaaccatt agatgtccgt tatagctttt ttgttcccaa gaagtccact ccaaaagtaa 2700
actctgtcac tagtcatggc agcaataaag tgggatcaca cacttcgcag ccgcagtggg 2760
tcacgggccc atggctcgcc tgctctagga cctgtgacac aggttggcac accagaacgg 2820
tgcagtgcca ggatggaaac cggaagttag caaaaggatg tcctctctcc caaaggcctt 2880
ctgcgtttaa gcaatgcttg ttgaagaaat gttagcctgt ggttatgatc ttatgcacaa 2940
agataactgg aggattcagc actgatgcag tcgtggtgaa caggaggtct acctaacgca 3000
cagaaagtca tgcttcagtg acattgtcaa caggagtcca attatgggca gaatctgctc 3060
tctgtgacca aaagaggatg tgcactgctt cacgtgacag tggtgacctt gcaatataga 3120
aaaacttggg agttattgaa catcccctgg gcttacaaga aacactgatg aatgtaaaat 3180
caggggacat ttgaagatgg cagaactgtc tcccccttgt cacctacctc tgatagaatg 3240
tctttaatgg tatcataatc attttcaccc ataatacaca gtagcttctt cttactgttt 3300
gtaaatacat tctcccttgg tatgtcactt tatatcccct ggttctatta aaatatccat 3360
atatatttct ataaaaaaag tgtttgacca aagtaggtct gcagctattt caacttcctt 3420
ccgtttccag aaagagctgt ggatatttta ctggaaatta agaacttgct gctgttttaa 3480
taagatgtag tatattttct gactacagga gataaaattt cagtcaaaaa accattttga 3540
cagcaagtat cttctgagaa attttgaaaa gtaaatagat ctcagtgtat ctagtcactt 3600
aaatacatac acgggttcat ttacttaaac ctttgactgc ctgtattttt ttcaggtagc 3660
tagccaaatt aatgcataat ttcagatgta gaagtagggt ttgcgtgtgt gtgtgtgatc 3720
atactcaaga gtctaaaaac tagtttcctt gtgttggaaa tttaaaagga aaaaaatcgt 3780
atttcactgt gttttcaatt tatattttca caactacttt ctctctccag agctttcatc 3840
tgatatctca caatgtatga tatacgtaca aaacacacag caagttttct atcatgtcca 3900
acacattcaa cactggtata cctcctacca gcaagccttt aaaatgcatt tgtgtttgct 3960
tatttgtttt gttcaagggt tcagtaagac ctacaatgtt ttgtatttct tgacttattt 4020
tattagaaac attaaagatc acttggtagt tagccacatt gagaagtggt tatcattgtt 4080
aatgtggtta atgccaaaaa gtggttaata ttaataagac tgtttccaca ccataggcaa 4140
taatttctta atttaaaaaa tctaagtata ttcctattgt actaaatatt tttcccaact 4200
ggaaagcact tgattgtacc cgtaagtgtt tgagtgatga catgtgatga ttttcagaaa 4260
gttgttgttt ttgtttccat agcctgttta agtaggttgt aagtttgaat agttagacat 4320
ggaaattatt ttataagcac acacctaaag atatcttttt agatgataaa atgtacaccc 4380
ccccatcacc aacctcacaa cttagaaaat ctaagttgtt tgatttcttt gggatttctt 4440
ttgttgtgaa acactgcaaa gccaattttt ctttataaaa attcatagta atcctgccaa 4500
atgtgcctat tgttaaagat ttgcatgtga agatcttagg gaaccactgt ttgagttcta 4560
caagctcatg agagtttatt tttattataa gatgttttta atataaaaga attatgtaac 4620
tgatcactat attacatcat ttcagtgggc caggaaaata gatgtcttgc tgttttcagt 4680
attttcttaa gaaattgctt ttaaaacaaa taattgtttt acaaaaccaa taattatcct 4740
ttgaattttc atagactgac tttgcttttg acgtagaaat tttttttctc aataaattat 4800
cactttgaga aatgaggcct gtacaaggct gataacctat atgtgatgga gatcacccaa 4860
tgccaagggc agaaagcaaa cctagttaaa taggtgagaa aaaaaataat aatcccagtg 4920
ccatttgtct gtgcaaagag aattaggaga gaggttaatg ttactttttt ccattttgga 4980
aataatttta atcaagtaac tcaaatgtga caaaatttat ttttattttt tgtggttata 5040
ttcccaacaa cattaaaaaa tactcgaggc ataaatgtag ttgtctccta ctctgcttct 5100
cttactatac tcatacattt ttaatatggt ttatcaatga ttcatgtttc cctcaaatag 5160
tgatggttta cacctgtcat ggaaacaatc ctagagagct cagagcaatt aaaccactat 5220
tccatgcttt taagtagttt tctccacctt tttcttatga gtctcactag attgactgag 5280
gaatgtatgt ctaaattcct ggagaagatg atatggattg gaaactgaaa ttcagagaaa 5340
tggagtgttc aatagatacc acgaattgtg aacaaaggga aaattctata caactcaatc 5400
taagtcagtc cactttgact tcgtactgtc tttcaccttt ccattgttgc atcttgaatt 5460
ttttaaaatg tctagaattc aggatgctag gggctacttc tttaaaaaaa aaaaaaaaaa 5520
agaattcgtc tgaaaatgct caggtttgta agaatctaat ctcacttaca taactaagca 5580
ctccataata agttttatta agtacaaagg gagccagaaa aaatgacatt tatttcttct 5640
agatcagaaa aatttaaatt aagccctgcc ttgctgttta gaaatatgtg ggcattgtta 5700
taatttattc aataaattta tgttcctttg ccttcctgtg gaaacagttt tatcccacta 5760
aactaggaat taggggataa atcacaaaca aaaaaaaagt tgcagcactg aaaaaaagta 5820
atttattgtt tttgcaactg gtatgtgaat ttgtgtgata aaattattta ttcttattta 5880
acaaaaatat gttcaaattt ttctatattt aaaatgtttt gctgttgtcc tactttttaa 5940
tttatgcttc atgtttgtgt ataaagtaca cttttacact ttgtgagttt acataatata 6000
cagcactggt tgcttttgta tttttttaca gaaagctttc tgtgtgaagc aggtgtatat 6060
gtatatattc ctcatgtatt cttattctga tactatcatt tttctttcca aggaaatttt 6120
aatctgtcat gaccaatagt gttcattact tgtgcctatg ataataggtt ttttacatca 6180
cattaacact attttttcca agtcacaaat aagaaaaaca cttattcaat gaaacaaggt 6240
gcaagtttta aatttgggta cacaaatagc ctagaagctt cctacagacg ctaagacaca 6300
gccaataatc agatcctttc acttcatcga gaaacttgga caagtcgata ttgatgtatt 6360
agatgaaagt tgtctacaca caacttctga gggatacaaa cgataataaa accaaatgtt 6420
gtctgtttct cctttagaaa cacctcctaa aattaatatc atttagtctc tagtgtctgt 6480
aggattctac agatgagcac aaatagattg ggtttgtata acaaatgcta atagtcataa 6540
ctgtttctac aaatatgggg tgtccattaa gagaatgtga tgttttccta ctgctgttga 6600
atcccatggg gtgattatag gacttgaaat aggcagagtc acctctgatg acatcagctt 6660
gcctctgtga tttcacagtc tgatcctggc aacaagacaa agcacccttg gacacacagc 6720
caatctctgg ttgtgatatt tccccattga ttccttcctt gttaacaagg tcattttaat 6780
ggttcaggtg aggacagcag ccagattcaa agtccagaat ttgtgctgtt acatagagtt 6840
cacactgtca aataacattg aatttaataa tgatcaaatt tttctagtag tctttggcag 6900
agtgtataat ctcattggca tgattggtga atattactaa tctctttata atgaaagatg 6960
ctttacaaat accttatatt tgctaacatt tcaaaactac taaataaatg aaatagccat 7020
gtgtacagaa atggtcattt aaagctttaa tagaaccaaa ttcaagacaa tgtatcattt 7080
agacacacag aaaaggaact tgtatgtttt ccctattatt tttctcattt gccaacaatc 7140
tatagtttta ggttatcaaa cagatagatc aacttaactg gctagtacat tgaaaaatct 7200
tcctaagaat cctttgttag cataatctat agagataatt tctcaaatta tatcatcatg 7260
atgcatataa actctataat gtataattgt gtttcattta tttaatgtat gagaacatat 7320
tgaaatacaa aaccatgcat tagccaaaaa attggaatac aggtagtgtt cagatcagca 7380
aaacattcag tctggtaaat gcctgcctgg ggctatgata tcattctcaa tgcaggtttt 7440
atggaaaaac taaaagaata tgttgttaga tgatgttggt tttgaaaaaa aaaagacatt 7500
aacatacaca ttagttagcc cagttaattg cattctacta atatagttgc acattagcaa 7560
taattttgct gtctctggtc tttattttgt ggcttcaact aactggacca tgtggactgt 7620
aaaggtcaaa tggaaaaaac gagcagtggc ccctcatcct gtaaggtact gctacatcag 7680
agtgacctaa aagtctaaca ctgtgaggaa aactgtgatt tgtaggaaaa aaaaaaaaaa 7740
caaataaaaa acagggcatg ctttttaatt tttttccact ttcctttggc acacccaatg 7800
aacaattcta atttttattg aggtgctaac atctttcgtg accgactgtc aaatgtggta 7860
tttttgagtt actatttttc tacatgattt tacagtttgc aagaaagacc tctaagcttt 7920
gtgtcacggt agggcacaac ttgatactca aaatttgaaa aataagcaca tccaatgatt 7980
gttttgacca acagtggtca gtgacgtaaa ctgcatgtgc atctgaggac atttaagggg 8040
tcattaaaat ttgaggagca tcaggccgga gtagcagact tttagatgag tcatatttca 8100
gcattcacta agtcctcagc attccattca aactgtcgtg tatatttggc ctgatttttt 8160
ttcaagcttt gcaataattt atgttattgg taaacacttg gtgactatat ctcagccttt 8220
tctttaacaa ctcacaatat attagaaaca cgtctaccta tactgagagt atatttacaa 8280
tagaagaaca tactgtatgt gactttgtaa agctagactt ttgattaaga aatatataat 8340
ctctggatgc tatttttgca ttatacactc aggcacaacg taaaccttga tggctcatct 8400
tgctacaatt acgagttgaa aaacactact tacgtatttg tatgacctat tagtcagagg 8460
aaatcataca tatgctttgt aaatagactt tgcagataac taaatagact gaagaaatat 8520
gttgcatttg atagaagcaa ttgcataaat atttggtttc tatattagag tctgtgagta 8580
aagtcaagta ataaacctaa gtaggtataa cagattttta aaccttgaaa cttgctttga 8640
tggtagagaa aatcattgaa gatttacata ctgtatataa gatgtaaaat gtacgctgct 8700
tattaccctc aattttccag aagcaatggt atataatgca gttgaaaaac caaaaatctt 8760
ggaaaactaa gacgggtctt gtttaaaatg tctctcagct ttggcaacct tcaaatctta 8820
atcaactatt taaagcatta ctgtgtcttg tagcctgcat tccacaacag ctctgttatt 8880
caggtaaaag acttgaactg agccgtttgg gacctatact gtaatatttt cattgaggaa 8940
caatatccta ttttgtaaag catttcccta tgtgtgactt taaactgtaa aattaaacac 9000
tgcttttgtg ggttcagtgg gcataataaa tataaattgt aaacta                9046



<210> 170
<211> 930
<212> PRT
<213> Homo sapiens

<220> 
<223> ADAMTS-5  precursor

<400> 170
Met Leu Leu Gly Trp Ala Ser Leu Leu Leu Cys Ala Phe Arg Leu Pro
 1               5                  10                  15      
Leu Ala Ala Val Gly Pro Ala Ala Thr Pro Ala Gln Asp Lys Ala Gly
            20                  25                  30          
Gln Pro Pro Thr Ala Ala Ala Ala Ala Gln Pro Arg Arg Arg Gln Gly
        35                  40                  45              
Glu Glu Val Gln Glu Arg Ala Glu Pro Pro Gly His Pro His Pro Leu
    50                  55                  60                  
Ala Gln Arg Arg Arg Ser Lys Gly Leu Val Gln Asn Ile Asp Gln Leu
65                  70                  75                  80  
Tyr Ser Gly Gly Gly Lys Val Gly Tyr Leu Val Tyr Ala Gly Gly Arg
                85                  90                  95      
Arg Phe Leu Leu Asp Leu Glu Arg Asp Gly Ser Val Gly Ile Ala Gly
            100                 105                 110         
Phe Val Pro Ala Gly Gly Gly Thr Ser Ala Pro Trp Arg His Arg Ser
        115                 120                 125             
His Cys Phe Tyr Arg Gly Thr Val Asp Ala Ser Pro Arg Ser Leu Ala
    130                 135                 140                 
Val Phe Asp Leu Cys Gly Gly Leu Asp Gly Phe Phe Ala Val Lys His
145                 150                 155                 160 
Ala Arg Tyr Thr Leu Lys Pro Leu Leu Arg Gly Pro Trp Ala Glu Glu
                165                 170                 175     
Glu Lys Gly Arg Val Tyr Gly Asp Gly Ser Ala Arg Ile Leu His Val
            180                 185                 190         
Tyr Thr Arg Glu Gly Phe Ser Phe Glu Ala Leu Pro Pro Arg Ala Ser
        195                 200                 205             
Cys Glu Thr Pro Ala Ser Thr Pro Glu Ala His Glu His Ala Pro Ala
    210                 215                 220                 
His Ser Asn Pro Ser Gly Arg Ala Ala Leu Ala Ser Gln Leu Leu Asp
225                 230                 235                 240 
Gln Ser Ala Leu Ser Pro Ala Gly Gly Ser Gly Pro Gln Thr Trp Trp
                245                 250                 255     
Arg Arg Arg Arg Arg Ser Ile Ser Arg Ala Arg Gln Val Glu Leu Leu
            260                 265                 270         
Leu Val Ala Asp Ala Ser Met Ala Arg Leu Tyr Gly Arg Gly Leu Gln
        275                 280                 285             
His Tyr Leu Leu Thr Leu Ala Ser Ile Ala Asn Arg Leu Tyr Ser His
    290                 295                 300                 
Ala Ser Ile Glu Asn His Ile Arg Leu Ala Val Val Lys Val Val Val
305                 310                 315                 320 
Leu Gly Asp Lys Asp Lys Ser Leu Glu Val Ser Lys Asn Ala Ala Thr
                325                 330                 335     
Thr Leu Lys Asn Phe Cys Lys Trp Gln His Gln His Asn Gln Leu Gly
            340                 345                 350         
Asp Asp His Glu Glu His Tyr Asp Ala Ala Ile Leu Phe Thr Arg Glu
        355                 360                 365             
Asp Leu Cys Gly His His Ser Cys Asp Thr Leu Gly Met Ala Asp Val
    370                 375                 380                 
Gly Thr Ile Cys Ser Pro Glu Arg Ser Cys Ala Val Ile Glu Asp Asp
385                 390                 395                 400 
Gly Leu His Ala Ala Phe Thr Val Ala His Glu Ile Gly His Leu Leu
                405                 410                 415     
Gly Leu Ser His Asp Asp Ser Lys Phe Cys Glu Glu Thr Phe Gly Ser
            420                 425                 430         
Thr Glu Asp Lys Arg Leu Met Ser Ser Ile Leu Thr Ser Ile Asp Ala
        435                 440                 445             
Ser Lys Pro Trp Ser Lys Cys Thr Ser Ala Thr Ile Thr Glu Phe Leu
    450                 455                 460                 
Asp Asp Gly His Gly Asn Cys Leu Leu Asp Leu Pro Arg Lys Gln Ile
465                 470                 475                 480 
Leu Gly Pro Glu Glu Leu Pro Gly Gln Thr Tyr Asp Ala Thr Gln Gln
                485                 490                 495     
Cys Asn Leu Thr Phe Gly Pro Glu Tyr Ser Val Cys Pro Gly Met Asp
            500                 505                 510         
Val Cys Ala Arg Leu Trp Cys Ala Val Val Arg Gln Gly Gln Met Val
        515                 520                 525             
Cys Leu Thr Lys Lys Leu Pro Ala Val Glu Gly Thr Pro Cys Gly Lys
    530                 535                 540                 
Gly Arg Ile Cys Leu Gln Gly Lys Cys Val Asp Lys Thr Lys Lys Lys
545                 550                 555                 560 
Tyr Tyr Ser Thr Ser Ser His Gly Asn Trp Gly Ser Trp Gly Ser Trp
                565                 570                 575     
Gly Gln Cys Ser Arg Ser Cys Gly Gly Gly Val Gln Phe Ala Tyr Arg
            580                 585                 590         
His Cys Asn Asn Pro Ala Pro Arg Asn Asn Gly Arg Tyr Cys Thr Gly
        595                 600                 605             
Lys Arg Ala Ile Tyr Arg Ser Cys Ser Leu Met Pro Cys Pro Pro Asn
    610                 615                 620                 
Gly Lys Ser Phe Arg His Glu Gln Cys Glu Ala Lys Asn Gly Tyr Gln
625                 630                 635                 640 
Ser Asp Ala Lys Gly Val Lys Thr Phe Val Glu Trp Val Pro Lys Tyr
                645                 650                 655     
Ala Gly Val Leu Pro Ala Asp Val Cys Lys Leu Thr Cys Arg Ala Lys
            660                 665                 670         
Gly Thr Gly Tyr Tyr Val Val Phe Ser Pro Lys Val Thr Asp Gly Thr
        675                 680                 685             
Glu Cys Arg Pro Tyr Ser Asn Ser Val Cys Val Arg Gly Lys Cys Val
    690                 695                 700                 
Arg Thr Gly Cys Asp Gly Ile Ile Gly Ser Lys Leu Gln Tyr Asp Lys
705                 710                 715                 720 
Cys Gly Val Cys Gly Gly Asp Asn Ser Ser Cys Thr Lys Ile Val Gly
                725                 730                 735     
Thr Phe Asn Lys Lys Ser Lys Gly Tyr Thr Asp Val Val Arg Ile Pro
            740                 745                 750         
Glu Gly Ala Thr His Ile Lys Val Arg Gln Phe Lys Ala Lys Asp Gln
        755                 760                 765             
Thr Arg Phe Thr Ala Tyr Leu Ala Leu Lys Lys Lys Asn Gly Glu Tyr
    770                 775                 780                 
Leu Ile Asn Gly Lys Tyr Met Ile Ser Thr Ser Glu Thr Ile Ile Asp
785                 790                 795                 800 
Ile Asn Gly Thr Val Met Asn Tyr Ser Gly Trp Ser His Arg Asp Asp
                805                 810                 815     
Phe Leu His Gly Met Gly Tyr Ser Ala Thr Lys Glu Ile Leu Ile Val
            820                 825                 830         
Gln Ile Leu Ala Thr Asp Pro Thr Lys Pro Leu Asp Val Arg Tyr Ser
        835                 840                 845             
Phe Phe Val Pro Lys Lys Ser Thr Pro Lys Val Asn Ser Val Thr Ser
    850                 855                 860                 
His Gly Ser Asn Lys Val Gly Ser His Thr Ser Gln Pro Gln Trp Val
865                 870                 875                 880 
Thr Gly Pro Trp Leu Ala Cys Ser Arg Thr Cys Asp Thr Gly Trp His
                885                 890                 895     
Thr Arg Thr Val Gln Cys Gln Asp Gly Asn Arg Lys Leu Ala Lys Gly
            900                 905                 910         
Cys Pro Leu Ser Gln Arg Pro Ser Ala Phe Lys Gln Cys Leu Leu Lys
        915                 920                 925             
Lys Cys
    930 


<210> 171
<211> 669
<212> PRT
<213> Homo sapiens

<220> 
<223> ADAMTS-5  mature

<400> 171
Ser Ile Ser Arg Ala Arg Gln Val Glu Leu Leu Leu Val Ala Asp Ala
 1               5                  10                  15      
Ser Met Ala Arg Leu Tyr Gly Arg Gly Leu Gln His Tyr Leu Leu Thr
            20                  25                  30          
Leu Ala Ser Ile Ala Asn Arg Leu Tyr Ser His Ala Ser Ile Glu Asn
        35                  40                  45              
His Ile Arg Leu Ala Val Val Lys Val Val Val Leu Gly Asp Lys Asp
    50                  55                  60                  
Lys Ser Leu Glu Val Ser Lys Asn Ala Ala Thr Thr Leu Lys Asn Phe
65                  70                  75                  80  
Cys Lys Trp Gln His Gln His Asn Gln Leu Gly Asp Asp His Glu Glu
                85                  90                  95      
His Tyr Asp Ala Ala Ile Leu Phe Thr Arg Glu Asp Leu Cys Gly His
            100                 105                 110         
His Ser Cys Asp Thr Leu Gly Met Ala Asp Val Gly Thr Ile Cys Ser
        115                 120                 125             
Pro Glu Arg Ser Cys Ala Val Ile Glu Asp Asp Gly Leu His Ala Ala
    130                 135                 140                 
Phe Thr Val Ala His Glu Ile Gly His Leu Leu Gly Leu Ser His Asp
145                 150                 155                 160 
Asp Ser Lys Phe Cys Glu Glu Thr Phe Gly Ser Thr Glu Asp Lys Arg
                165                 170                 175     
Leu Met Ser Ser Ile Leu Thr Ser Ile Asp Ala Ser Lys Pro Trp Ser
            180                 185                 190         
Lys Cys Thr Ser Ala Thr Ile Thr Glu Phe Leu Asp Asp Gly His Gly
        195                 200                 205             
Asn Cys Leu Leu Asp Leu Pro Arg Lys Gln Ile Leu Gly Pro Glu Glu
    210                 215                 220                 
Leu Pro Gly Gln Thr Tyr Asp Ala Thr Gln Gln Cys Asn Leu Thr Phe
225                 230                 235                 240 
Gly Pro Glu Tyr Ser Val Cys Pro Gly Met Asp Val Cys Ala Arg Leu
                245                 250                 255     
Trp Cys Ala Val Val Arg Gln Gly Gln Met Val Cys Leu Thr Lys Lys
            260                 265                 270         
Leu Pro Ala Val Glu Gly Thr Pro Cys Gly Lys Gly Arg Ile Cys Leu
        275                 280                 285             
Gln Gly Lys Cys Val Asp Lys Thr Lys Lys Lys Tyr Tyr Ser Thr Ser
    290                 295                 300                 
Ser His Gly Asn Trp Gly Ser Trp Gly Ser Trp Gly Gln Cys Ser Arg
305                 310                 315                 320 
Ser Cys Gly Gly Gly Val Gln Phe Ala Tyr Arg His Cys Asn Asn Pro
                325                 330                 335     
Ala Pro Arg Asn Asn Gly Arg Tyr Cys Thr Gly Lys Arg Ala Ile Tyr
            340                 345                 350         
Arg Ser Cys Ser Leu Met Pro Cys Pro Pro Asn Gly Lys Ser Phe Arg
        355                 360                 365             
His Glu Gln Cys Glu Ala Lys Asn Gly Tyr Gln Ser Asp Ala Lys Gly
    370                 375                 380                 
Val Lys Thr Phe Val Glu Trp Val Pro Lys Tyr Ala Gly Val Leu Pro
385                 390                 395                 400 
Ala Asp Val Cys Lys Leu Thr Cys Arg Ala Lys Gly Thr Gly Tyr Tyr
                405                 410                 415     
Val Val Phe Ser Pro Lys Val Thr Asp Gly Thr Glu Cys Arg Pro Tyr
            420                 425                 430         
Ser Asn Ser Val Cys Val Arg Gly Lys Cys Val Arg Thr Gly Cys Asp
        435                 440                 445             
Gly Ile Ile Gly Ser Lys Leu Gln Tyr Asp Lys Cys Gly Val Cys Gly
    450                 455                 460                 
Gly Asp Asn Ser Ser Cys Thr Lys Ile Val Gly Thr Phe Asn Lys Lys
465                 470                 475                 480 
Ser Lys Gly Tyr Thr Asp Val Val Arg Ile Pro Glu Gly Ala Thr His
                485                 490                 495     
Ile Lys Val Arg Gln Phe Lys Ala Lys Asp Gln Thr Arg Phe Thr Ala
            500                 505                 510         
Tyr Leu Ala Leu Lys Lys Lys Asn Gly Glu Tyr Leu Ile Asn Gly Lys
        515                 520                 525             
Tyr Met Ile Ser Thr Ser Glu Thr Ile Ile Asp Ile Asn Gly Thr Val
    530                 535                 540                 
Met Asn Tyr Ser Gly Trp Ser His Arg Asp Asp Phe Leu His Gly Met
545                 550                 555                 560 
Gly Tyr Ser Ala Thr Lys Glu Ile Leu Ile Val Gln Ile Leu Ala Thr
                565                 570                 575     
Asp Pro Thr Lys Pro Leu Asp Val Arg Tyr Ser Phe Phe Val Pro Lys
            580                 585                 590         
Lys Ser Thr Pro Lys Val Asn Ser Val Thr Ser His Gly Ser Asn Lys
        595                 600                 605             
Val Gly Ser His Thr Ser Gln Pro Gln Trp Val Thr Gly Pro Trp Leu
    610                 615                 620                 
Ala Cys Ser Arg Thr Cys Asp Thr Gly Trp His Thr Arg Thr Val Gln
625                 630                 635                 640 
Cys Gln Asp Gly Asn Arg Lys Leu Ala Lys Gly Cys Pro Leu Ser Gln
                645                 650                 655     
Arg Pro Ser Ala Phe Lys Gln Cys Leu Leu Lys Lys Cys
            660                 665                 


<210> 172
<211> 5269
<212> DNA
<213> Homo sapiens

<220> 
<221> unsure         
<222> (0)...(0)
<223> ADAMTS14  transcript variant 1

<400> 172
atggctccac tccgcgcgct gctgtcctac ctgctgcctt tgcactgtgc gctctgcgcc 60
gccgcgggca gccggacccc agagctgcac ctctctggaa agctcagtga ctatggtgtg 120
acagtgccct gcagcacaga ctttcgggga cgcttcctct cccacgtggt gtctggccca 180
gcagcagcct ctgcagggag catggtagtg gacacgccac ccacactacc acgacactcc 240
agtcacctcc gggtggctcg cagccctctg cacccaggag ggaccctgtg gcctggcagg 300
gtggggcgcc actccctcta cttcaatgtc actgttttcg ggaaggaact gcacttgcgc 360
ctgcggccca atcggaggtt ggtagtgcca ggatcctcag tggagtggca ggaggatttt 420
cgggagctgt tccggcagcc cttacggcag gagtgtgtgt acactggagg tgtcactgga 480
atgcctgggg cagctgttgc catcagcaac tgtgacggat tggcgggcct catccgcaca 540
gacagcaccg acttcttcat tgagcctctg gagcggggcc agcaggagaa ggaggccagc 600
gggaggacac atgtggtgta ccgccgggag gccgtccagc aggagtgggc agaacctgac 660
ggggacctgc acaatgaagc ctttggcctg ggagaccttc ccaacctgct gggcctggtg 720
ggggaccagc tgggcgacac agagcggaag cggcggcatg ccaagccagg cagctacagc 780
atcgaggtgc tgctggtggt ggacgactcg gtggttcgct tccatggcaa ggagcatgtg 840
cagaactatg tcctcaccct catgaatatc gtagatgaga tttaccacga tgagtccctg 900
ggggttcata taaatattgc cctcgtccgc ttgatcatgg ttggctaccg acagtccctg 960
agcctgatcg agcgcgggaa cccctcacgc agcctggagc aggtgtgtcg ctgggcacac 1020
tcccagcagc gccaggaccc cagccacgct gagcaccatg accacgttgt gttcctcacc 1080
cggcaggact ttgggccctc aggtatgcaa gggtatgcac ccgtcactgg catgtgtcac 1140
cccctgagga gctgtgccct caaccatgag gatggcttct cctcagcctt cgtgatagct 1200
catgagaccg gccacgtgct cggcatggag catgacggtc aggggaatgg ctgtgcagat 1260
gagaccagcc tgggcagcgt catggcgccc ctggtgcagg ctgccttcca ccgcttccat 1320
tggtcccgct gcagcaagct ggagctcagc cgctacctcc cctcctacga ctgcctcctc 1380
gatgacccct ttgatcctgc ctggccccag cccccagagc tgcctgggat caactactca 1440
atggatgagc agtgccgctt tgactttggc agtggctacc agacctgctt ggcattcagg 1500
acctttgagc cctgcaagca gctgtggtgc agccatcctg acaacccgta cttctgcaag 1560
accaagaagg ggcccccgct ggatgggact gagtgtgcac ccggcaagtg gtgcttcaaa 1620
ggtcactgca tctggaagtc gccggagcag acatatggcc aggatggagg ctggagctcc 1680
tggaccaagt ttgggtcatg ttcgcggtca tgtgggggcg gggtgcgatc ccgcagccgg 1740
agctgcaaca acccctcccc agcctatgga ggccgcctgt gcttagggcc catgttcgag 1800
taccaggtct gcaacagcga ggagtgccct gggacctacg aggacttccg ggcccagcag 1860
tgtgccaagc gcaactccta ctatgtgcac cagaatgcca agcacagctg ggtgccctac 1920
gagcctgacg atgacgccca gaagtgtgag ctgatctgcc agtcggcgga cacgggggac 1980
gtggtgttca tgaaccaggt ggttcacgat gggacacgct gcagctaccg ggacccatac 2040
agcgtctgtg cgcgtggcga gtgtgtgcct gtcggctgtg acaaggaggt ggggtccatg 2100
aaggcggatg acaagtgtgg agtctgcggg ggtgacaact cccactgcag gactgtgaag 2160
gggacgctgg gcaaggcctc caagcaggca ggagctctca agctggtgca gatcccagca 2220
ggtgccaggc acatccagat tgaggcactg gagaagtccc cccaccgcat tgtggtgaag 2280
aaccaggtca ccggcagctt catcctcaac cccaagggca aggaagccac aagccggacc 2340
ttcaccgcca tgggcctgga gtgggaggat gcggtggagg atgccaagga aagcctcaag 2400
accagcgggc ccctgcctga agccattgcc atcctggctc tccccccaac tgagggtggc 2460
ccccgcagca gcctggccta caagtacgtc atccatgagg acctgctgcc ccttatcggg 2520
agcaacaatg tgctcctgga ggagatggac acctatgagt gggcgctcaa gagctgggcc 2580
ccctgcagca aggcctgtgg aggagggatc cagttcacca aatacggctg ccggcgcaga 2640
cgagaccacc acatggtgca gcgacacctg tgtgaccaca agaagaggcc caagcccatc 2700
cgccggcgct gcaaccagca cccgtgctct cagcctgtgt gggtgacgga ggagtggggt 2760
gcctgcagcc ggagctgtgg gaagctgggg gtgcagacac gggggataca gtgcctgctg 2820
cccctctcca atggaaccca caaggtcatg ccggccaaag cctgcgccgg ggaccggcct 2880
gaggcccgac ggccctgtct ccgagtgccc tgcccagccc agtggaggct gggagcctgg 2940
tcccagtgct ctgccacctg tggagagggc atccagcagc ggcaggtggt gtgcaggacc 3000
aacgccaaca gcctcgggca ttgcgagggg gataggccag acactgtcca ggtctgcagc 3060
ctgcccgcct gtggaggaaa tcaccagaac tccacggtga gggccgatgt ctgggaactt 3120
gggacgccag aggggcagtg ggtgccacaa tctgaacccc tacatcccat taacaagata 3180
tcatcaacgg agccctgcac gggagacagg tctgtcttct gccagatgga agtgctcgat 3240
cgctactgct ccattcccgg ctaccaccgg ctctgctgtg tgtcctgcat caagaaggcc 3300
tcgggcccca accctggccc agaccctggc ccaacctcac tgcccccctt ctccactcct 3360
ggaagcccct taccaggacc ccaggaccct gcagatgctg cagagcctcc tggaaagcca 3420
acgggatcag aggaccatca gcatggccga gccacacagc tcccaggagc tctggataca 3480
agctccccag ggacccagca tccctttgcc cctgagacac caatccctgg agcatcctgg 3540
agcatctccc ctaccacccc cggggggctg ccttggggct ggactcagac acctacgcca 3600
gtccctgagg acaaagggca acctggagaa gacctgagac atcccggcac cagcctccct 3660
gctgcctccc cggtgacatg agctgtgccc tgccatccca ctggcacgtt tacactctgt 3720
gtactgcccc gtgactccca gctcagagga cacacatagc agggcaggcg caagcacaga 3780
cttcatttta aatcattcgc cttcttctcg tttggggctg tgatgctctt taccccacaa 3840
agcggggtgg gaggaagaca aagatcaggg aaagccctaa tcggagatac ctcagcaagc 3900
tgcccccggc gggactgacc ctctcagggc ccctgttggt ctcccctgcc aagaccaggg 3960
tcaactattg ctccctcctc acagaccctg ggcctgggca ggtctgaatc ccggctggtc 4020
tgtagctaga agctgtcagg gctgcctgcc ttcccggaac tgtgaggacc cctgtggagg 4080
ccctgcatat ttggcccctc tccccagaaa ggcaaagcag ggccagggta ggtgggggac 4140
tgttcacagc caggccgaga ggaggggggc ctgggaatgt ggcatgaggc ttcccagctg 4200
cagggctgga gggggtggaa cacaaggtga tcgcaggccc agctcctgga agccaagagc 4260
tccatgcagt tccaccagct gaggccaggc agcagaggcc agtttgtctt tgctggccag 4320
aagatggtgc tcatggccat actctggcct tgcagatgtc actagtgtta cttctagtga 4380
ctccagatta cagactggcc ccccaatctc accccagccc accagagaag ggggctcagg 4440
acaccctgga ccccaagtcc tcagcatcca gggatttcca aactggcgct cactccctga 4500
ctccaccagg atggcaactt caattatcac tctcagcctg gaaggggact ctgtgggaca 4560
cagagggaac acgatttctc aggctgtccc ttcaatcatt gcccttctcc gaagatcgct 4620
cctgctggag tcggacatct tcatcttcta cctggctcaa gctgggccag agtgtgtggt 4680
tctcccaggg gtggttggac cccaggactg aggaccagag tccactcata gcctggccct 4740
ggagatgaca agggccaccc aggccaagtg ccccagggca gggtgccagc ccctggcctg 4800
gtgctggagt ggggaagaca cactcaccca cggtgctgta agggcctgag ctgtgctcag 4860
ctgccggcca tgctacctcc aagggacagg taacagtctt agatcctctg gctctcagga 4920
agtggcaggg ggtcccagga cacctccggg gtcttggagg atgtctccta aactcctgcc 4980
aggtgataga ggtgcttctc acttcttcct tccccaaggc aaaggggctg ttctgagcca 5040
gcctggagga acatgagtag tgggcccctg gcctgcaacc cctttggaga gtggaggtcc 5100
tggggggctc cccgccctcc ccctgttgcc ctcccctccc tgggatgctg gggcacacgc 5160
ggagtcattc ctgtgagaac cagcctggcc tgtgttaaac tcttgtgcct tggaaatcca 5220
gatctttaaa attttatgta tttattaaca tcgccattgg accccaaaa             5269



<210> 173
<211> 1226
<212> PRT
<213> Homo sapiens

<220> 
<223> ADAMTS14 isoform 1 precursor

<400> 173
Met Ala Pro Leu Arg Ala Leu Leu Ser Tyr Leu Leu Pro Leu His Cys
 1               5                  10                  15      
Ala Leu Cys Ala Ala Ala Gly Ser Arg Thr Pro Glu Leu His Leu Ser
            20                  25                  30          
Gly Lys Leu Ser Asp Tyr Gly Val Thr Val Pro Cys Ser Thr Asp Phe
        35                  40                  45              
Arg Gly Arg Phe Leu Ser His Val Val Ser Gly Pro Ala Ala Ala Ser
    50                  55                  60                  
Ala Gly Ser Met Val Val Asp Thr Pro Pro Thr Leu Pro Arg His Ser
65                  70                  75                  80  
Ser His Leu Arg Val Ala Arg Ser Pro Leu His Pro Gly Gly Thr Leu
                85                  90                  95      
Trp Pro Gly Arg Val Gly Arg His Ser Leu Tyr Phe Asn Val Thr Val
            100                 105                 110         
Phe Gly Lys Glu Leu His Leu Arg Leu Arg Pro Asn Arg Arg Leu Val
        115                 120                 125             
Val Pro Gly Ser Ser Val Glu Trp Gln Glu Asp Phe Arg Glu Leu Phe
    130                 135                 140                 
Arg Gln Pro Leu Arg Gln Glu Cys Val Tyr Thr Gly Gly Val Thr Gly
145                 150                 155                 160 
Met Pro Gly Ala Ala Val Ala Ile Ser Asn Cys Asp Gly Leu Ala Gly
                165                 170                 175     
Leu Ile Arg Thr Asp Ser Thr Asp Phe Phe Ile Glu Pro Leu Glu Arg
            180                 185                 190         
Gly Gln Gln Glu Lys Glu Ala Ser Gly Arg Thr His Val Val Tyr Arg
        195                 200                 205             
Arg Glu Ala Val Gln Gln Glu Trp Ala Glu Pro Asp Gly Asp Leu His
    210                 215                 220                 
Asn Glu Ala Phe Gly Leu Gly Asp Leu Pro Asn Leu Leu Gly Leu Val
225                 230                 235                 240 
Gly Asp Gln Leu Gly Asp Thr Glu Arg Lys Arg Arg His Ala Lys Pro
                245                 250                 255     
Gly Ser Tyr Ser Ile Glu Val Leu Leu Val Val Asp Asp Ser Val Val
            260                 265                 270         
Arg Phe His Gly Lys Glu His Val Gln Asn Tyr Val Leu Thr Leu Met
        275                 280                 285             
Asn Ile Val Asp Glu Ile Tyr His Asp Glu Ser Leu Gly Val His Ile
    290                 295                 300                 
Asn Ile Ala Leu Val Arg Leu Ile Met Val Gly Tyr Arg Gln Ser Leu
305                 310                 315                 320 
Ser Leu Ile Glu Arg Gly Asn Pro Ser Arg Ser Leu Glu Gln Val Cys
                325                 330                 335     
Arg Trp Ala His Ser Gln Gln Arg Gln Asp Pro Ser His Ala Glu His
            340                 345                 350         
His Asp His Val Val Phe Leu Thr Arg Gln Asp Phe Gly Pro Ser Gly
        355                 360                 365             
Met Gln Gly Tyr Ala Pro Val Thr Gly Met Cys His Pro Leu Arg Ser
    370                 375                 380                 
Cys Ala Leu Asn His Glu Asp Gly Phe Ser Ser Ala Phe Val Ile Ala
385                 390                 395                 400 
His Glu Thr Gly His Val Leu Gly Met Glu His Asp Gly Gln Gly Asn
                405                 410                 415     
Gly Cys Ala Asp Glu Thr Ser Leu Gly Ser Val Met Ala Pro Leu Val
            420                 425                 430         
Gln Ala Ala Phe His Arg Phe His Trp Ser Arg Cys Ser Lys Leu Glu
        435                 440                 445             
Leu Ser Arg Tyr Leu Pro Ser Tyr Asp Cys Leu Leu Asp Asp Pro Phe
    450                 455                 460                 
Asp Pro Ala Trp Pro Gln Pro Pro Glu Leu Pro Gly Ile Asn Tyr Ser
465                 470                 475                 480 
Met Asp Glu Gln Cys Arg Phe Asp Phe Gly Ser Gly Tyr Gln Thr Cys
                485                 490                 495     
Leu Ala Phe Arg Thr Phe Glu Pro Cys Lys Gln Leu Trp Cys Ser His
            500                 505                 510         
Pro Asp Asn Pro Tyr Phe Cys Lys Thr Lys Lys Gly Pro Pro Leu Asp
        515                 520                 525             
Gly Thr Glu Cys Ala Pro Gly Lys Trp Cys Phe Lys Gly His Cys Ile
    530                 535                 540                 
Trp Lys Ser Pro Glu Gln Thr Tyr Gly Gln Asp Gly Gly Trp Ser Ser
545                 550                 555                 560 
Trp Thr Lys Phe Gly Ser Cys Ser Arg Ser Cys Gly Gly Gly Val Arg
                565                 570                 575     
Ser Arg Ser Arg Ser Cys Asn Asn Pro Ser Pro Ala Tyr Gly Gly Arg
            580                 585                 590         
Leu Cys Leu Gly Pro Met Phe Glu Tyr Gln Val Cys Asn Ser Glu Glu
        595                 600                 605             
Cys Pro Gly Thr Tyr Glu Asp Phe Arg Ala Gln Gln Cys Ala Lys Arg
    610                 615                 620                 
Asn Ser Tyr Tyr Val His Gln Asn Ala Lys His Ser Trp Val Pro Tyr
625                 630                 635                 640 
Glu Pro Asp Asp Asp Ala Gln Lys Cys Glu Leu Ile Cys Gln Ser Ala
                645                 650                 655     
Asp Thr Gly Asp Val Val Phe Met Asn Gln Val Val His Asp Gly Thr
            660                 665                 670         
Arg Cys Ser Tyr Arg Asp Pro Tyr Ser Val Cys Ala Arg Gly Glu Cys
        675                 680                 685             
Val Pro Val Gly Cys Asp Lys Glu Val Gly Ser Met Lys Ala Asp Asp
    690                 695                 700                 
Lys Cys Gly Val Cys Gly Gly Asp Asn Ser His Cys Arg Thr Val Lys
705                 710                 715                 720 
Gly Thr Leu Gly Lys Ala Ser Lys Gln Ala Gly Ala Leu Lys Leu Val
                725                 730                 735     
Gln Ile Pro Ala Gly Ala Arg His Ile Gln Ile Glu Ala Leu Glu Lys
            740                 745                 750         
Ser Pro His Arg Ile Val Val Lys Asn Gln Val Thr Gly Ser Phe Ile
        755                 760                 765             
Leu Asn Pro Lys Gly Lys Glu Ala Thr Ser Arg Thr Phe Thr Ala Met
    770                 775                 780                 
Gly Leu Glu Trp Glu Asp Ala Val Glu Asp Ala Lys Glu Ser Leu Lys
785                 790                 795                 800 
Thr Ser Gly Pro Leu Pro Glu Ala Ile Ala Ile Leu Ala Leu Pro Pro
                805                 810                 815     
Thr Glu Gly Gly Pro Arg Ser Ser Leu Ala Tyr Lys Tyr Val Ile His
            820                 825                 830         
Glu Asp Leu Leu Pro Leu Ile Gly Ser Asn Asn Val Leu Leu Glu Glu
        835                 840                 845             
Met Asp Thr Tyr Glu Trp Ala Leu Lys Ser Trp Ala Pro Cys Ser Lys
    850                 855                 860                 
Ala Cys Gly Gly Gly Ile Gln Phe Thr Lys Tyr Gly Cys Arg Arg Arg
865                 870                 875                 880 
Arg Asp His His Met Val Gln Arg His Leu Cys Asp His Lys Lys Arg
                885                 890                 895     
Pro Lys Pro Ile Arg Arg Arg Cys Asn Gln His Pro Cys Ser Gln Pro
            900                 905                 910         
Val Trp Val Thr Glu Glu Trp Gly Ala Cys Ser Arg Ser Cys Gly Lys
        915                 920                 925             
Leu Gly Val Gln Thr Arg Gly Ile Gln Cys Leu Leu Pro Leu Ser Asn
    930                 935                 940                 
Gly Thr His Lys Val Met Pro Ala Lys Ala Cys Ala Gly Asp Arg Pro
945                 950                 955                 960 
Glu Ala Arg Arg Pro Cys Leu Arg Val Pro Cys Pro Ala Gln Trp Arg
                965                 970                 975     
Leu Gly Ala Trp Ser Gln Cys Ser Ala Thr Cys Gly Glu Gly Ile Gln
            980                 985                 990         
Gln Arg Gln Val Val Cys Arg Thr Asn Ala Asn Ser Leu Gly His Cys
        995                 1000                1005            
Glu Gly Asp Arg Pro Asp Thr Val Gln Val Cys Ser Leu Pro Ala Cys
    1010                1015                1020                
Gly Gly Asn His Gln Asn Ser Thr Val Arg Ala Asp Val Trp Glu Leu
1025                1030                1035                1040
Gly Thr Pro Glu Gly Gln Trp Val Pro Gln Ser Glu Pro Leu His Pro
                1045                1050                1055    
Ile Asn Lys Ile Ser Ser Thr Glu Pro Cys Thr Gly Asp Arg Ser Val
            1060                1065                1070        
Phe Cys Gln Met Glu Val Leu Asp Arg Tyr Cys Ser Ile Pro Gly Tyr
        1075                1080                1085            
His Arg Leu Cys Cys Val Ser Cys Ile Lys Lys Ala Ser Gly Pro Asn
    1090                1095                1100                
Pro Gly Pro Asp Pro Gly Pro Thr Ser Leu Pro Pro Phe Ser Thr Pro
1105                1110                1115                1120
Gly Ser Pro Leu Pro Gly Pro Gln Asp Pro Ala Asp Ala Ala Glu Pro
                1125                1130                1135    
Pro Gly Lys Pro Thr Gly Ser Glu Asp His Gln His Gly Arg Ala Thr
            1140                1145                1150        
Gln Leu Pro Gly Ala Leu Asp Thr Ser Ser Pro Gly Thr Gln His Pro
        1155                1160                1165            
Phe Ala Pro Glu Thr Pro Ile Pro Gly Ala Ser Trp Ser Ile Ser Pro
    1170                1175                1180                
Thr Thr Pro Gly Gly Leu Pro Trp Gly Trp Thr Gln Thr Pro Thr Pro
1185                1190                1195                1200
Val Pro Glu Asp Lys Gly Gln Pro Gly Glu Asp Leu Arg His Pro Gly
                1205                1210                1215    
Thr Ser Leu Pro Ala Ala Ser Pro Val Thr
            1220                1225    


<210> 174
<211> 974
<212> PRT
<213> Homo sapiens

<220> 
<223> ADAMTS14 isoform 1 mature

<400> 174
His Ala Lys Pro Gly Ser Tyr Ser Ile Glu Val Leu Leu Val Val Asp
 1               5                  10                  15      
Asp Ser Val Val Arg Phe His Gly Lys Glu His Val Gln Asn Tyr Val
            20                  25                  30          
Leu Thr Leu Met Asn Ile Val Asp Glu Ile Tyr His Asp Glu Ser Leu
        35                  40                  45              
Gly Val His Ile Asn Ile Ala Leu Val Arg Leu Ile Met Val Gly Tyr
    50                  55                  60                  
Arg Gln Ser Leu Ser Leu Ile Glu Arg Gly Asn Pro Ser Arg Ser Leu
65                  70                  75                  80  
Glu Gln Val Cys Arg Trp Ala His Ser Gln Gln Arg Gln Asp Pro Ser
                85                  90                  95      
His Ala Glu His His Asp His Val Val Phe Leu Thr Arg Gln Asp Phe
            100                 105                 110         
Gly Pro Ser Gly Met Gln Gly Tyr Ala Pro Val Thr Gly Met Cys His
        115                 120                 125             
Pro Leu Arg Ser Cys Ala Leu Asn His Glu Asp Gly Phe Ser Ser Ala
    130                 135                 140                 
Phe Val Ile Ala His Glu Thr Gly His Val Leu Gly Met Glu His Asp
145                 150                 155                 160 
Gly Gln Gly Asn Gly Cys Ala Asp Glu Thr Ser Leu Gly Ser Val Met
                165                 170                 175     
Ala Pro Leu Val Gln Ala Ala Phe His Arg Phe His Trp Ser Arg Cys
            180                 185                 190         
Ser Lys Leu Glu Leu Ser Arg Tyr Leu Pro Ser Tyr Asp Cys Leu Leu
        195                 200                 205             
Asp Asp Pro Phe Asp Pro Ala Trp Pro Gln Pro Pro Glu Leu Pro Gly
    210                 215                 220                 
Ile Asn Tyr Ser Met Asp Glu Gln Cys Arg Phe Asp Phe Gly Ser Gly
225                 230                 235                 240 
Tyr Gln Thr Cys Leu Ala Phe Arg Thr Phe Glu Pro Cys Lys Gln Leu
                245                 250                 255     
Trp Cys Ser His Pro Asp Asn Pro Tyr Phe Cys Lys Thr Lys Lys Gly
            260                 265                 270         
Pro Pro Leu Asp Gly Thr Glu Cys Ala Pro Gly Lys Trp Cys Phe Lys
        275                 280                 285             
Gly His Cys Ile Trp Lys Ser Pro Glu Gln Thr Tyr Gly Gln Asp Gly
    290                 295                 300                 
Gly Trp Ser Ser Trp Thr Lys Phe Gly Ser Cys Ser Arg Ser Cys Gly
305                 310                 315                 320 
Gly Gly Val Arg Ser Arg Ser Arg Ser Cys Asn Asn Pro Ser Pro Ala
                325                 330                 335     
Tyr Gly Gly Arg Leu Cys Leu Gly Pro Met Phe Glu Tyr Gln Val Cys
            340                 345                 350         
Asn Ser Glu Glu Cys Pro Gly Thr Tyr Glu Asp Phe Arg Ala Gln Gln
        355                 360                 365             
Cys Ala Lys Arg Asn Ser Tyr Tyr Val His Gln Asn Ala Lys His Ser
    370                 375                 380                 
Trp Val Pro Tyr Glu Pro Asp Asp Asp Ala Gln Lys Cys Glu Leu Ile
385                 390                 395                 400 
Cys Gln Ser Ala Asp Thr Gly Asp Val Val Phe Met Asn Gln Val Val
                405                 410                 415     
His Asp Gly Thr Arg Cys Ser Tyr Arg Asp Pro Tyr Ser Val Cys Ala
            420                 425                 430         
Arg Gly Glu Cys Val Pro Val Gly Cys Asp Lys Glu Val Gly Ser Met
        435                 440                 445             
Lys Ala Asp Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser His Cys
    450                 455                 460                 
Arg Thr Val Lys Gly Thr Leu Gly Lys Ala Ser Lys Gln Ala Gly Ala
465                 470                 475                 480 
Leu Lys Leu Val Gln Ile Pro Ala Gly Ala Arg His Ile Gln Ile Glu
                485                 490                 495     
Ala Leu Glu Lys Ser Pro His Arg Ile Val Val Lys Asn Gln Val Thr
            500                 505                 510         
Gly Ser Phe Ile Leu Asn Pro Lys Gly Lys Glu Ala Thr Ser Arg Thr
        515                 520                 525             
Phe Thr Ala Met Gly Leu Glu Trp Glu Asp Ala Val Glu Asp Ala Lys
    530                 535                 540                 
Glu Ser Leu Lys Thr Ser Gly Pro Leu Pro Glu Ala Ile Ala Ile Leu
545                 550                 555                 560 
Ala Leu Pro Pro Thr Glu Gly Gly Pro Arg Ser Ser Leu Ala Tyr Lys
                565                 570                 575     
Tyr Val Ile His Glu Asp Leu Leu Pro Leu Ile Gly Ser Asn Asn Val
            580                 585                 590         
Leu Leu Glu Glu Met Asp Thr Tyr Glu Trp Ala Leu Lys Ser Trp Ala
        595                 600                 605             
Pro Cys Ser Lys Ala Cys Gly Gly Gly Ile Gln Phe Thr Lys Tyr Gly
    610                 615                 620                 
Cys Arg Arg Arg Arg Asp His His Met Val Gln Arg His Leu Cys Asp
625                 630                 635                 640 
His Lys Lys Arg Pro Lys Pro Ile Arg Arg Arg Cys Asn Gln His Pro
                645                 650                 655     
Cys Ser Gln Pro Val Trp Val Thr Glu Glu Trp Gly Ala Cys Ser Arg
            660                 665                 670         
Ser Cys Gly Lys Leu Gly Val Gln Thr Arg Gly Ile Gln Cys Leu Leu
        675                 680                 685             
Pro Leu Ser Asn Gly Thr His Lys Val Met Pro Ala Lys Ala Cys Ala
    690                 695                 700                 
Gly Asp Arg Pro Glu Ala Arg Arg Pro Cys Leu Arg Val Pro Cys Pro
705                 710                 715                 720 
Ala Gln Trp Arg Leu Gly Ala Trp Ser Gln Cys Ser Ala Thr Cys Gly
                725                 730                 735     
Glu Gly Ile Gln Gln Arg Gln Val Val Cys Arg Thr Asn Ala Asn Ser
            740                 745                 750         
Leu Gly His Cys Glu Gly Asp Arg Pro Asp Thr Val Gln Val Cys Ser
        755                 760                 765             
Leu Pro Ala Cys Gly Gly Asn His Gln Asn Ser Thr Val Arg Ala Asp
    770                 775                 780                 
Val Trp Glu Leu Gly Thr Pro Glu Gly Gln Trp Val Pro Gln Ser Glu
785                 790                 795                 800 
Pro Leu His Pro Ile Asn Lys Ile Ser Ser Thr Glu Pro Cys Thr Gly
                805                 810                 815     
Asp Arg Ser Val Phe Cys Gln Met Glu Val Leu Asp Arg Tyr Cys Ser
            820                 825                 830         
Ile Pro Gly Tyr His Arg Leu Cys Cys Val Ser Cys Ile Lys Lys Ala
        835                 840                 845             
Ser Gly Pro Asn Pro Gly Pro Asp Pro Gly Pro Thr Ser Leu Pro Pro
    850                 855                 860                 
Phe Ser Thr Pro Gly Ser Pro Leu Pro Gly Pro Gln Asp Pro Ala Asp
865                 870                 875                 880 
Ala Ala Glu Pro Pro Gly Lys Pro Thr Gly Ser Glu Asp His Gln His
                885                 890                 895     
Gly Arg Ala Thr Gln Leu Pro Gly Ala Leu Asp Thr Ser Ser Pro Gly
            900                 905                 910         
Thr Gln His Pro Phe Ala Pro Glu Thr Pro Ile Pro Gly Ala Ser Trp
        915                 920                 925             
Ser Ile Ser Pro Thr Thr Pro Gly Gly Leu Pro Trp Gly Trp Thr Gln
    930                 935                 940                 
Thr Pro Thr Pro Val Pro Glu Asp Lys Gly Gln Pro Gly Glu Asp Leu
945                 950                 955                 960 
Arg His Pro Gly Thr Ser Leu Pro Ala Ala Ser Pro Val Thr
                965                 970                 


<210> 175
<211> 5260
<212> DNA
<213> Homo sapiens

<220> 
<223> ADAMTS14  transcript variant 2

<400> 175
atggctccac tccgcgcgct gctgtcctac ctgctgcctt tgcactgtgc gctctgcgcc 60
gccgcgggca gccggacccc agagctgcac ctctctggaa agctcagtga ctatggtgtg 120
acagtgccct gcagcacaga ctttcgggga cgcttcctct cccacgtggt gtctggccca 180
gcagcagcct ctgcagggag catggtagtg gacacgccac ccacactacc acgacactcc 240
agtcacctcc gggtggctcg cagccctctg cacccaggag ggaccctgtg gcctggcagg 300
gtggggcgcc actccctcta cttcaatgtc actgttttcg ggaaggaact gcacttgcgc 360
ctgcggccca atcggaggtt ggtagtgcca ggatcctcag tggagtggca ggaggatttt 420
cgggagctgt tccggcagcc cttacggcag gagtgtgtgt acactggagg tgtcactgga 480
atgcctgggg cagctgttgc catcagcaac tgtgacggat tggcgggcct catccgcaca 540
gacagcaccg acttcttcat tgagcctctg gagcggggcc agcaggagaa ggaggccagc 600
gggaggacac atgtggtgta ccgccgggag gccgtccagc aggagtgggc agaacctgac 660
ggggacctgc acaatgaagc ctttggcctg ggagaccttc ccaacctgct gggcctggtg 720
ggggaccagc tgggcgacac agagcggaag cggcggcatg ccaagccagg cagctacagc 780
atcgaggtgc tgctggtggt ggacgactcg gtggttcgct tccatggcaa ggagcatgtg 840
cagaactatg tcctcaccct catgaatatc gtagatgaga tttaccacga tgagtccctg 900
ggggttcata taaatattgc cctcgtccgc ttgatcatgg ttggctaccg acagtccctg 960
agcctgatcg agcgcgggaa cccctcacgc agcctggagc aggtgtgtcg ctgggcacac 1020
tcccagcagc gccaggaccc cagccacgct gagcaccatg accacgttgt gttcctcacc 1080
cggcaggact ttgggccctc agggtatgca cccgtcactg gcatgtgtca ccccctgagg 1140
agctgtgccc tcaaccatga ggatggcttc tcctcagcct tcgtgatagc tcatgagacc 1200
ggccacgtgc tcggcatgga gcatgacggt caggggaatg gctgtgcaga tgagaccagc 1260
ctgggcagcg tcatggcgcc cctggtgcag gctgccttcc accgcttcca ttggtcccgc 1320
tgcagcaagc tggagctcag ccgctacctc ccctcctacg actgcctcct cgatgacccc 1380
tttgatcctg cctggcccca gcccccagag ctgcctggga tcaactactc aatggatgag 1440
cagtgccgct ttgactttgg cagtggctac cagacctgct tggcattcag gacctttgag 1500
ccctgcaagc agctgtggtg cagccatcct gacaacccgt acttctgcaa gaccaagaag 1560
gggcccccgc tggatgggac tgagtgtgca cccggcaagt ggtgcttcaa aggtcactgc 1620
atctggaagt cgccggagca gacatatggc caggatggag gctggagctc ctggaccaag 1680
tttgggtcat gttcgcggtc atgtgggggc ggggtgcgat cccgcagccg gagctgcaac 1740
aacccctccc cagcctatgg aggccgcctg tgcttagggc ccatgttcga gtaccaggtc 1800
tgcaacagcg aggagtgccc tgggacctac gaggacttcc gggcccagca gtgtgccaag 1860
cgcaactcct actatgtgca ccagaatgcc aagcacagct gggtgcccta cgagcctgac 1920
gatgacgccc agaagtgtga gctgatctgc cagtcggcgg acacggggga cgtggtgttc 1980
atgaaccagg tggttcacga tgggacacgc tgcagctacc gggacccata cagcgtctgt 2040
gcgcgtggcg agtgtgtgcc tgtcggctgt gacaaggagg tggggtccat gaaggcggat 2100
gacaagtgtg gagtctgcgg gggtgacaac tcccactgca ggactgtgaa ggggacgctg 2160
ggcaaggcct ccaagcaggc aggagctctc aagctggtgc agatcccagc aggtgccagg 2220
cacatccaga ttgaggcact ggagaagtcc ccccaccgca ttgtggtgaa gaaccaggtc 2280
accggcagct tcatcctcaa ccccaagggc aaggaagcca caagccggac cttcaccgcc 2340
atgggcctgg agtgggagga tgcggtggag gatgccaagg aaagcctcaa gaccagcggg 2400
cccctgcctg aagccattgc catcctggct ctccccccaa ctgagggtgg cccccgcagc 2460
agcctggcct acaagtacgt catccatgag gacctgctgc cccttatcgg gagcaacaat 2520
gtgctcctgg aggagatgga cacctatgag tgggcgctca agagctgggc cccctgcagc 2580
aaggcctgtg gaggagggat ccagttcacc aaatacggct gccggcgcag acgagaccac 2640
cacatggtgc agcgacacct gtgtgaccac aagaagaggc ccaagcccat ccgccggcgc 2700
tgcaaccagc acccgtgctc tcagcctgtg tgggtgacgg aggagtgggg tgcctgcagc 2760
cggagctgtg ggaagctggg ggtgcagaca cgggggatac agtgcctgct gcccctctcc 2820
aatggaaccc acaaggtcat gccggccaaa gcctgcgccg gggaccggcc tgaggcccga 2880
cggccctgtc tccgagtgcc ctgcccagcc cagtggaggc tgggagcctg gtcccagtgc 2940
tctgccacct gtggagaggg catccagcag cggcaggtgg tgtgcaggac caacgccaac 3000
agcctcgggc attgcgaggg ggataggcca gacactgtcc aggtctgcag cctgcccgcc 3060
tgtggaggaa atcaccagaa ctccacggtg agggccgatg tctgggaact tgggacgcca 3120
gaggggcagt gggtgccaca atctgaaccc ctacatccca ttaacaagat atcatcaacg 3180
gagccctgca cgggagacag gtctgtcttc tgccagatgg aagtgctcga tcgctactgc 3240
tccattcccg gctaccaccg gctctgctgt gtgtcctgca tcaagaaggc ctcgggcccc 3300
aaccctggcc cagaccctgg cccaacctca ctgcccccct tctccactcc tggaagcccc 3360
ttaccaggac cccaggaccc tgcagatgct gcagagcctc ctggaaagcc aacgggatca 3420
gaggaccatc agcatggccg agccacacag ctcccaggag ctctggatac aagctcccca 3480
gggacccagc atccctttgc ccctgagaca ccaatccctg gagcatcctg gagcatctcc 3540
cctaccaccc ccggggggct gccttggggc tggactcaga cacctacgcc agtccctgag 3600
gacaaagggc aacctggaga agacctgaga catcccggca ccagcctccc tgctgcctcc 3660
ccggtgacat gagctgtgcc ctgccatccc actggcacgt ttacactctg tgtactgccc 3720
cgtgactccc agctcagagg acacacatag cagggcaggc gcaagcacag acttcatttt 3780
aaatcattcg ccttcttctc gtttggggct gtgatgctct ttaccccaca aagcggggtg 3840
ggaggaagac aaagatcagg gaaagcccta atcggagata cctcagcaag ctgcccccgg 3900
cgggactgac cctctcaggg cccctgttgg tctcccctgc caagaccagg gtcaactatt 3960
gctccctcct cacagaccct gggcctgggc aggtctgaat cccggctggt ctgtagctag 4020
aagctgtcag ggctgcctgc cttcccggaa ctgtgaggac ccctgtggag gccctgcata 4080
tttggcccct ctccccagaa aggcaaagca gggccagggt aggtggggga ctgttcacag 4140
ccaggccgag aggagggggg cctgggaatg tggcatgagg cttcccagct gcagggctgg 4200
agggggtgga acacaaggtg atcgcaggcc cagctcctgg aagccaagag ctccatgcag 4260
ttccaccagc tgaggccagg cagcagaggc cagtttgtct ttgctggcca gaagatggtg 4320
ctcatggcca tactctggcc ttgcagatgt cactagtgtt acttctagtg actccagatt 4380
acagactggc cccccaatct caccccagcc caccagagaa gggggctcag gacaccctgg 4440
accccaagtc ctcagcatcc agggatttcc aaactggcgc tcactccctg actccaccag 4500
gatggcaact tcaattatca ctctcagcct ggaaggggac tctgtgggac acagagggaa 4560
cacgatttct caggctgtcc cttcaatcat tgcccttctc cgaagatcgc tcctgctgga 4620
gtcggacatc ttcatcttct acctggctca agctgggcca gagtgtgtgg ttctcccagg 4680
ggtggttgga ccccaggact gaggaccaga gtccactcat agcctggccc tggagatgac 4740
aagggccacc caggccaagt gccccagggc agggtgccag cccctggcct ggtgctggag 4800
tggggaagac acactcaccc acggtgctgt aagggcctga gctgtgctca gctgccggcc 4860
atgctacctc caagggacag gtaacagtct tagatcctct ggctctcagg aagtggcagg 4920
gggtcccagg acacctccgg ggtcttggag gatgtctcct aaactcctgc caggtgatag 4980
aggtgcttct cacttcttcc ttccccaagg caaaggggct gttctgagcc agcctggagg 5040
aacatgagta gtgggcccct ggcctgcaac ccctttggag agtggaggtc ctggggggct 5100
ccccgccctc cccctgttgc cctcccctcc ctgggatgct ggggcacacg cggagtcatt 5160
cctgtgagaa ccagcctggc ctgtgttaaa ctcttgtgcc ttggaaatcc agatctttaa 5220
aattttatgt atttattaac atcgccattg gaccccaaaa                       5260



<210> 176
<211> 1223
<212> PRT
<213> Homo sapiens

<220> 
<223> ADAMTS14 isoform b precursor

<400> 176
Met Ala Pro Leu Arg Ala Leu Leu Ser Tyr Leu Leu Pro Leu His Cys
 1               5                  10                  15      
Ala Leu Cys Ala Ala Ala Gly Ser Arg Thr Pro Glu Leu His Leu Ser
            20                  25                  30          
Gly Lys Leu Ser Asp Tyr Gly Val Thr Val Pro Cys Ser Thr Asp Phe
        35                  40                  45              
Arg Gly Arg Phe Leu Ser His Val Val Ser Gly Pro Ala Ala Ala Ser
    50                  55                  60                  
Ala Gly Ser Met Val Val Asp Thr Pro Pro Thr Leu Pro Arg His Ser
65                  70                  75                  80  
Ser His Leu Arg Val Ala Arg Ser Pro Leu His Pro Gly Gly Thr Leu
                85                  90                  95      
Trp Pro Gly Arg Val Gly Arg His Ser Leu Tyr Phe Asn Val Thr Val
            100                 105                 110         
Phe Gly Lys Glu Leu His Leu Arg Leu Arg Pro Asn Arg Arg Leu Val
        115                 120                 125             
Val Pro Gly Ser Ser Val Glu Trp Gln Glu Asp Phe Arg Glu Leu Phe
    130                 135                 140                 
Arg Gln Pro Leu Arg Gln Glu Cys Val Tyr Thr Gly Gly Val Thr Gly
145                 150                 155                 160 
Met Pro Gly Ala Ala Val Ala Ile Ser Asn Cys Asp Gly Leu Ala Gly
                165                 170                 175     
Leu Ile Arg Thr Asp Ser Thr Asp Phe Phe Ile Glu Pro Leu Glu Arg
            180                 185                 190         
Gly Gln Gln Glu Lys Glu Ala Ser Gly Arg Thr His Val Val Tyr Arg
        195                 200                 205             
Arg Glu Ala Val Gln Gln Glu Trp Ala Glu Pro Asp Gly Asp Leu His
    210                 215                 220                 
Asn Glu Ala Phe Gly Leu Gly Asp Leu Pro Asn Leu Leu Gly Leu Val
225                 230                 235                 240 
Gly Asp Gln Leu Gly Asp Thr Glu Arg Lys Arg Arg His Ala Lys Pro
                245                 250                 255     
Gly Ser Tyr Ser Ile Glu Val Leu Leu Val Val Asp Asp Ser Val Val
            260                 265                 270         
Arg Phe His Gly Lys Glu His Val Gln Asn Tyr Val Leu Thr Leu Met
        275                 280                 285             
Asn Ile Val Asp Glu Ile Tyr His Asp Glu Ser Leu Gly Val His Ile
    290                 295                 300                 
Asn Ile Ala Leu Val Arg Leu Ile Met Val Gly Tyr Arg Gln Ser Leu
305                 310                 315                 320 
Ser Leu Ile Glu Arg Gly Asn Pro Ser Arg Ser Leu Glu Gln Val Cys
                325                 330                 335     
Arg Trp Ala His Ser Gln Gln Arg Gln Asp Pro Ser His Ala Glu His
            340                 345                 350         
His Asp His Val Val Phe Leu Thr Arg Gln Asp Phe Gly Pro Ser Gly
        355                 360                 365             
Tyr Ala Pro Val Thr Gly Met Cys His Pro Leu Arg Ser Cys Ala Leu
    370                 375                 380                 
Asn His Glu Asp Gly Phe Ser Ser Ala Phe Val Ile Ala His Glu Thr
385                 390                 395                 400 
Gly His Val Leu Gly Met Glu His Asp Gly Gln Gly Asn Gly Cys Ala
                405                 410                 415     
Asp Glu Thr Ser Leu Gly Ser Val Met Ala Pro Leu Val Gln Ala Ala
            420                 425                 430         
Phe His Arg Phe His Trp Ser Arg Cys Ser Lys Leu Glu Leu Ser Arg
        435                 440                 445             
Tyr Leu Pro Ser Tyr Asp Cys Leu Leu Asp Asp Pro Phe Asp Pro Ala
    450                 455                 460                 
Trp Pro Gln Pro Pro Glu Leu Pro Gly Ile Asn Tyr Ser Met Asp Glu
465                 470                 475                 480 
Gln Cys Arg Phe Asp Phe Gly Ser Gly Tyr Gln Thr Cys Leu Ala Phe
                485                 490                 495     
Arg Thr Phe Glu Pro Cys Lys Gln Leu Trp Cys Ser His Pro Asp Asn
            500                 505                 510         
Pro Tyr Phe Cys Lys Thr Lys Lys Gly Pro Pro Leu Asp Gly Thr Glu
        515                 520                 525             
Cys Ala Pro Gly Lys Trp Cys Phe Lys Gly His Cys Ile Trp Lys Ser
    530                 535                 540                 
Pro Glu Gln Thr Tyr Gly Gln Asp Gly Gly Trp Ser Ser Trp Thr Lys
545                 550                 555                 560 
Phe Gly Ser Cys Ser Arg Ser Cys Gly Gly Gly Val Arg Ser Arg Ser
                565                 570                 575     
Arg Ser Cys Asn Asn Pro Ser Pro Ala Tyr Gly Gly Arg Leu Cys Leu
            580                 585                 590         
Gly Pro Met Phe Glu Tyr Gln Val Cys Asn Ser Glu Glu Cys Pro Gly
        595                 600                 605             
Thr Tyr Glu Asp Phe Arg Ala Gln Gln Cys Ala Lys Arg Asn Ser Tyr
    610                 615                 620                 
Tyr Val His Gln Asn Ala Lys His Ser Trp Val Pro Tyr Glu Pro Asp
625                 630                 635                 640 
Asp Asp Ala Gln Lys Cys Glu Leu Ile Cys Gln Ser Ala Asp Thr Gly
                645                 650                 655     
Asp Val Val Phe Met Asn Gln Val Val His Asp Gly Thr Arg Cys Ser
            660                 665                 670         
Tyr Arg Asp Pro Tyr Ser Val Cys Ala Arg Gly Glu Cys Val Pro Val
        675                 680                 685             
Gly Cys Asp Lys Glu Val Gly Ser Met Lys Ala Asp Asp Lys Cys Gly
    690                 695                 700                 
Val Cys Gly Gly Asp Asn Ser His Cys Arg Thr Val Lys Gly Thr Leu
705                 710                 715                 720 
Gly Lys Ala Ser Lys Gln Ala Gly Ala Leu Lys Leu Val Gln Ile Pro
                725                 730                 735     
Ala Gly Ala Arg His Ile Gln Ile Glu Ala Leu Glu Lys Ser Pro His
            740                 745                 750         
Arg Ile Val Val Lys Asn Gln Val Thr Gly Ser Phe Ile Leu Asn Pro
        755                 760                 765             
Lys Gly Lys Glu Ala Thr Ser Arg Thr Phe Thr Ala Met Gly Leu Glu
    770                 775                 780                 
Trp Glu Asp Ala Val Glu Asp Ala Lys Glu Ser Leu Lys Thr Ser Gly
785                 790                 795                 800 
Pro Leu Pro Glu Ala Ile Ala Ile Leu Ala Leu Pro Pro Thr Glu Gly
                805                 810                 815     
Gly Pro Arg Ser Ser Leu Ala Tyr Lys Tyr Val Ile His Glu Asp Leu
            820                 825                 830         
Leu Pro Leu Ile Gly Ser Asn Asn Val Leu Leu Glu Glu Met Asp Thr
        835                 840                 845             
Tyr Glu Trp Ala Leu Lys Ser Trp Ala Pro Cys Ser Lys Ala Cys Gly
    850                 855                 860                 
Gly Gly Ile Gln Phe Thr Lys Tyr Gly Cys Arg Arg Arg Arg Asp His
865                 870                 875                 880 
His Met Val Gln Arg His Leu Cys Asp His Lys Lys Arg Pro Lys Pro
                885                 890                 895     
Ile Arg Arg Arg Cys Asn Gln His Pro Cys Ser Gln Pro Val Trp Val
            900                 905                 910         
Thr Glu Glu Trp Gly Ala Cys Ser Arg Ser Cys Gly Lys Leu Gly Val
        915                 920                 925             
Gln Thr Arg Gly Ile Gln Cys Leu Leu Pro Leu Ser Asn Gly Thr His
    930                 935                 940                 
Lys Val Met Pro Ala Lys Ala Cys Ala Gly Asp Arg Pro Glu Ala Arg
945                 950                 955                 960 
Arg Pro Cys Leu Arg Val Pro Cys Pro Ala Gln Trp Arg Leu Gly Ala
                965                 970                 975     
Trp Ser Gln Cys Ser Ala Thr Cys Gly Glu Gly Ile Gln Gln Arg Gln
            980                 985                 990         
Val Val Cys Arg Thr Asn Ala Asn Ser Leu Gly His Cys Glu Gly Asp
        995                 1000                1005            
Arg Pro Asp Thr Val Gln Val Cys Ser Leu Pro Ala Cys Gly Gly Asn
    1010                1015                1020                
His Gln Asn Ser Thr Val Arg Ala Asp Val Trp Glu Leu Gly Thr Pro
1025                1030                1035                1040
Glu Gly Gln Trp Val Pro Gln Ser Glu Pro Leu His Pro Ile Asn Lys
                1045                1050                1055    
Ile Ser Ser Thr Glu Pro Cys Thr Gly Asp Arg Ser Val Phe Cys Gln
            1060                1065                1070        
Met Glu Val Leu Asp Arg Tyr Cys Ser Ile Pro Gly Tyr His Arg Leu
        1075                1080                1085            
Cys Cys Val Ser Cys Ile Lys Lys Ala Ser Gly Pro Asn Pro Gly Pro
    1090                1095                1100                
Asp Pro Gly Pro Thr Ser Leu Pro Pro Phe Ser Thr Pro Gly Ser Pro
1105                1110                1115                1120
Leu Pro Gly Pro Gln Asp Pro Ala Asp Ala Ala Glu Pro Pro Gly Lys
                1125                1130                1135    
Pro Thr Gly Ser Glu Asp His Gln His Gly Arg Ala Thr Gln Leu Pro
            1140                1145                1150        
Gly Ala Leu Asp Thr Ser Ser Pro Gly Thr Gln His Pro Phe Ala Pro
        1155                1160                1165            
Glu Thr Pro Ile Pro Gly Ala Ser Trp Ser Ile Ser Pro Thr Thr Pro
    1170                1175                1180                
Gly Gly Leu Pro Trp Gly Trp Thr Gln Thr Pro Thr Pro Val Pro Glu
1185                1190                1195                1200
Asp Lys Gly Gln Pro Gly Glu Asp Leu Arg His Pro Gly Thr Ser Leu
                1205                1210                1215    
Pro Ala Ala Ser Pro Val Thr
            1220            


<210> 177
<211> 971
<212> PRT
<213> Homo sapiens

<220> 
<223> ADAMTS14 isoform 2 mature

<400> 177
His Ala Lys Pro Gly Ser Tyr Ser Ile Glu Val Leu Leu Val Val Asp
 1               5                  10                  15      
Asp Ser Val Val Arg Phe His Gly Lys Glu His Val Gln Asn Tyr Val
            20                  25                  30          
Leu Thr Leu Met Asn Ile Val Asp Glu Ile Tyr His Asp Glu Ser Leu
        35                  40                  45              
Gly Val His Ile Asn Ile Ala Leu Val Arg Leu Ile Met Val Gly Tyr
    50                  55                  60                  
Arg Gln Ser Leu Ser Leu Ile Glu Arg Gly Asn Pro Ser Arg Ser Leu
65                  70                  75                  80  
Glu Gln Val Cys Arg Trp Ala His Ser Gln Gln Arg Gln Asp Pro Ser
                85                  90                  95      
His Ala Glu His His Asp His Val Val Phe Leu Thr Arg Gln Asp Phe
            100                 105                 110         
Gly Pro Ser Gly Tyr Ala Pro Val Thr Gly Met Cys His Pro Leu Arg
        115                 120                 125             
Ser Cys Ala Leu Asn His Glu Asp Gly Phe Ser Ser Ala Phe Val Ile
    130                 135                 140                 
Ala His Glu Thr Gly His Val Leu Gly Met Glu His Asp Gly Gln Gly
145                 150                 155                 160 
Asn Gly Cys Ala Asp Glu Thr Ser Leu Gly Ser Val Met Ala Pro Leu
                165                 170                 175     
Val Gln Ala Ala Phe His Arg Phe His Trp Ser Arg Cys Ser Lys Leu
            180                 185                 190         
Glu Leu Ser Arg Tyr Leu Pro Ser Tyr Asp Cys Leu Leu Asp Asp Pro
        195                 200                 205             
Phe Asp Pro Ala Trp Pro Gln Pro Pro Glu Leu Pro Gly Ile Asn Tyr
    210                 215                 220                 
Ser Met Asp Glu Gln Cys Arg Phe Asp Phe Gly Ser Gly Tyr Gln Thr
225                 230                 235                 240 
Cys Leu Ala Phe Arg Thr Phe Glu Pro Cys Lys Gln Leu Trp Cys Ser
                245                 250                 255     
His Pro Asp Asn Pro Tyr Phe Cys Lys Thr Lys Lys Gly Pro Pro Leu
            260                 265                 270         
Asp Gly Thr Glu Cys Ala Pro Gly Lys Trp Cys Phe Lys Gly His Cys
        275                 280                 285             
Ile Trp Lys Ser Pro Glu Gln Thr Tyr Gly Gln Asp Gly Gly Trp Ser
    290                 295                 300                 
Ser Trp Thr Lys Phe Gly Ser Cys Ser Arg Ser Cys Gly Gly Gly Val
305                 310                 315                 320 
Arg Ser Arg Ser Arg Ser Cys Asn Asn Pro Ser Pro Ala Tyr Gly Gly
                325                 330                 335     
Arg Leu Cys Leu Gly Pro Met Phe Glu Tyr Gln Val Cys Asn Ser Glu
            340                 345                 350         
Glu Cys Pro Gly Thr Tyr Glu Asp Phe Arg Ala Gln Gln Cys Ala Lys
        355                 360                 365             
Arg Asn Ser Tyr Tyr Val His Gln Asn Ala Lys His Ser Trp Val Pro
    370                 375                 380                 
Tyr Glu Pro Asp Asp Asp Ala Gln Lys Cys Glu Leu Ile Cys Gln Ser
385                 390                 395                 400 
Ala Asp Thr Gly Asp Val Val Phe Met Asn Gln Val Val His Asp Gly
                405                 410                 415     
Thr Arg Cys Ser Tyr Arg Asp Pro Tyr Ser Val Cys Ala Arg Gly Glu
            420                 425                 430         
Cys Val Pro Val Gly Cys Asp Lys Glu Val Gly Ser Met Lys Ala Asp
        435                 440                 445             
Asp Lys Cys Gly Val Cys Gly Gly Asp Asn Ser His Cys Arg Thr Val
    450                 455                 460                 
Lys Gly Thr Leu Gly Lys Ala Ser Lys Gln Ala Gly Ala Leu Lys Leu
465                 470                 475                 480 
Val Gln Ile Pro Ala Gly Ala Arg His Ile Gln Ile Glu Ala Leu Glu
                485                 490                 495     
Lys Ser Pro His Arg Ile Val Val Lys Asn Gln Val Thr Gly Ser Phe
            500                 505                 510         
Ile Leu Asn Pro Lys Gly Lys Glu Ala Thr Ser Arg Thr Phe Thr Ala
        515                 520                 525             
Met Gly Leu Glu Trp Glu Asp Ala Val Glu Asp Ala Lys Glu Ser Leu
    530                 535                 540                 
Lys Thr Ser Gly Pro Leu Pro Glu Ala Ile Ala Ile Leu Ala Leu Pro
545                 550                 555                 560 
Pro Thr Glu Gly Gly Pro Arg Ser Ser Leu Ala Tyr Lys Tyr Val Ile
                565                 570                 575     
His Glu Asp Leu Leu Pro Leu Ile Gly Ser Asn Asn Val Leu Leu Glu
            580                 585                 590         
Glu Met Asp Thr Tyr Glu Trp Ala Leu Lys Ser Trp Ala Pro Cys Ser
        595                 600                 605             
Lys Ala Cys Gly Gly Gly Ile Gln Phe Thr Lys Tyr Gly Cys Arg Arg
    610                 615                 620                 
Arg Arg Asp His His Met Val Gln Arg His Leu Cys Asp His Lys Lys
625                 630                 635                 640 
Arg Pro Lys Pro Ile Arg Arg Arg Cys Asn Gln His Pro Cys Ser Gln
                645                 650                 655     
Pro Val Trp Val Thr Glu Glu Trp Gly Ala Cys Ser Arg Ser Cys Gly
            660                 665                 670         
Lys Leu Gly Val Gln Thr Arg Gly Ile Gln Cys Leu Leu Pro Leu Ser
        675                 680                 685             
Asn Gly Thr His Lys Val Met Pro Ala Lys Ala Cys Ala Gly Asp Arg
    690                 695                 700                 
Pro Glu Ala Arg Arg Pro Cys Leu Arg Val Pro Cys Pro Ala Gln Trp
705                 710                 715                 720 
Arg Leu Gly Ala Trp Ser Gln Cys Ser Ala Thr Cys Gly Glu Gly Ile
                725                 730                 735     
Gln Gln Arg Gln Val Val Cys Arg Thr Asn Ala Asn Ser Leu Gly His
            740                 745                 750         
Cys Glu Gly Asp Arg Pro Asp Thr Val Gln Val Cys Ser Leu Pro Ala
        755                 760                 765             
Cys Gly Gly Asn His Gln Asn Ser Thr Val Arg Ala Asp Val Trp Glu
    770                 775                 780                 
Leu Gly Thr Pro Glu Gly Gln Trp Val Pro Gln Ser Glu Pro Leu His
785                 790                 795                 800 
Pro Ile Asn Lys Ile Ser Ser Thr Glu Pro Cys Thr Gly Asp Arg Ser
                805                 810                 815     
Val Phe Cys Gln Met Glu Val Leu Asp Arg Tyr Cys Ser Ile Pro Gly
            820                 825                 830         
Tyr His Arg Leu Cys Cys Val Ser Cys Ile Lys Lys Ala Ser Gly Pro
        835                 840                 845             
Asn Pro Gly Pro Asp Pro Gly Pro Thr Ser Leu Pro Pro Phe Ser Thr
    850                 855                 860                 
Pro Gly Ser Pro Leu Pro Gly Pro Gln Asp Pro Ala Asp Ala Ala Glu
865                 870                 875                 880 
Pro Pro Gly Lys Pro Thr Gly Ser Glu Asp His Gln His Gly Arg Ala
                885                 890                 895     
Thr Gln Leu Pro Gly Ala Leu Asp Thr Ser Ser Pro Gly Thr Gln His
            900                 905                 910         
Pro Phe Ala Pro Glu Thr Pro Ile Pro Gly Ala Ser Trp Ser Ile Ser
        915                 920                 925             
Pro Thr Thr Pro Gly Gly Leu Pro Trp Gly Trp Thr Gln Thr Pro Thr
    930                 935                 940                 
Pro Val Pro Glu Asp Lys Gly Gln Pro Gly Glu Asp Leu Arg His Pro
945                 950                 955                 960 
Gly Thr Ser Leu Pro Ala Ala Ser Pro Val Thr
                965                 970     


<210> 178
<211> 1904
<212> DNA
<213> Homo sapiens

<220> 
<223> Cathepsin C

<400> 178
agctatttca aggcgcgcgc ctcgtggtgg actcaccgct agcccgcagc gctcggcttc 60
ctggtaattc ttcacctctt ttctcagctc cctgcagcat gggtgctggg ccctccttgc 120
tgctcgccgc cctcctgctg cttctctccg gcgacggcgc cgtgcgctgc gacacacctg 180
ccaactgcac ctatcttgac ctgctgggca cctgggtctt ccaggtgggc tccagcggtt 240
cccagcgcga tgtcaactgc tcggttatgg gaccacaaga aaaaaaagta gtggtgtacc 300
ttcagaagct ggatacagca tatgatgacc ttggcaattc tggccatttc accatcattt 360
acaaccaagg ctttgagatt gtgttgaatg actacaagtg gtttgccttt tttaagtata 420
aagaagaggg cagcaaggtg accacttact gcaacgagac aatgactggg tgggtgcatg 480
atgtgttggg ccggaactgg gcttgtttca ccggaaagaa ggtgggaact gcctctgaga 540
atgtgtatgt caacacagca caccttaaga attctcagga aaagtattct aataggctct 600
acaagtatga tcacaacttt gtgaaagcta tcaatgccat tcagaagtct tggactgcaa 660
ctacatacat ggaatatgag actcttaccc tgggagatat gattaggaga agtggtggcc 720
acagtcgaaa aatcccaagg cccaaacctg caccactgac tgctgaaata cagcaaaaga 780
ttttgcattt gccaacatct tgggactgga gaaatgttca tggtatcaat tttgtcagtc 840
ctgttcgaaa ccaagcatcc tgtggcagct gctactcatt tgcttctatg ggtatgctag 900
aagcgagaat ccgtatacta accaacaatt ctcagacccc aatcctaagc cctcaggagg 960
ttgtgtcttg tagccagtat gctcaaggct gtgaaggcgg cttcccatac cttattgcag 1020
gaaagtacgc ccaagatttt gggctggtgg aagaagcttg cttcccctac acaggcactg 1080
attctccatg caaaatgaag gaagactgct ttcgttatta ctcctctgag taccactatg 1140
taggaggttt ctatggaggc tgcaatgaag ccctgatgaa gcttgagttg gtccatcatg 1200
ggcccatggc agttgctttt gaagtatatg atgacttcct ccactacaaa aaggggatct 1260
accaccacac tggtctaaga gaccctttca acccctttga gctgactaat catgctgttc 1320
tgcttgtggg ctatggcact gactcagcct ctgggatgga ttactggatt gttaaaaaca 1380
gctggggcac cggctggggt gagaatggct acttccggat ccgcagagga actgatgagt 1440
gtgcaattga gagcatagca gtggcagcca caccaattcc taaattgtag ggtatgcctt 1500
ccagtatttc ataatgatct gcatcagttg taaaggggaa ttggtatatt cacagactgt 1560
agactttcag cagcaatctc agaagcttac aaatagattt ccatgaagat atttgtcttc 1620
agaattaaaa ctgcccttaa ttttaatata cctttcaatc ggccactggc catttttttc 1680
taagtattca attaagtggg aattttctgg aagatggtca gctatgaagt aatagagttt 1740
gcttaatcat ttgtaattca aacatgctat attttttaaa atcaatgtga aaacatagac 1800
ttatttttaa attgtaccaa tcacaagaaa ataatggcaa taattatcaa aacttttaaa 1860
atagatgctc atatttttaa aataaagttt taaaaataac tgca                  1904

<210> 179
<211> 463
<212> PRT
<213> Homo sapiens

<220> 
<223> Cathepsin C precursor

<400> 179
Met Gly Ala Gly Pro Ser Leu Leu Leu Ala Ala Leu Leu Leu Leu Leu
 1               5                  10                  15      
Ser Gly Asp Gly Ala Val Arg Cys Asp Thr Pro Ala Asn Cys Thr Tyr
            20                  25                  30          
Leu Asp Leu Leu Gly Thr Trp Val Phe Gln Val Gly Ser Ser Gly Ser
        35                  40                  45              
Gln Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys Val
    50                  55                  60                  
Val Val Tyr Leu Gln Lys Leu Asp Thr Ala Tyr Asp Asp Leu Gly Asn
65                  70                  75                  80  
Ser Gly His Phe Thr Ile Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu
                85                  90                  95      
Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Tyr Lys Glu Glu Gly Ser
            100                 105                 110         
Lys Val Thr Thr Tyr Cys Asn Glu Thr Met Thr Gly Trp Val His Asp
        115                 120                 125             
Val Leu Gly Arg Asn Trp Ala Cys Phe Thr Gly Lys Lys Val Gly Thr
    130                 135                 140                 
Ala Ser Glu Asn Val Tyr Val Asn Thr Ala His Leu Lys Asn Ser Gln
145                 150                 155                 160 
Glu Lys Tyr Ser Asn Arg Leu Tyr Lys Tyr Asp His Asn Phe Val Lys
                165                 170                 175     
Ala Ile Asn Ala Ile Gln Lys Ser Trp Thr Ala Thr Thr Tyr Met Glu
            180                 185                 190         
Tyr Glu Thr Leu Thr Leu Gly Asp Met Ile Arg Arg Ser Gly Gly His
        195                 200                 205             
Ser Arg Lys Ile Pro Arg Pro Lys Pro Ala Pro Leu Thr Ala Glu Ile
    210                 215                 220                 
Gln Gln Lys Ile Leu His Leu Pro Thr Ser Trp Asp Trp Arg Asn Val
225                 230                 235                 240 
His Gly Ile Asn Phe Val Ser Pro Val Arg Asn Gln Ala Ser Cys Gly
                245                 250                 255     
Ser Cys Tyr Ser Phe Ala Ser Met Gly Met Leu Glu Ala Arg Ile Arg
            260                 265                 270         
Ile Leu Thr Asn Asn Ser Gln Thr Pro Ile Leu Ser Pro Gln Glu Val
        275                 280                 285             
Val Ser Cys Ser Gln Tyr Ala Gln Gly Cys Glu Gly Gly Phe Pro Tyr
    290                 295                 300                 
Leu Ile Ala Gly Lys Tyr Ala Gln Asp Phe Gly Leu Val Glu Glu Ala
305                 310                 315                 320 
Cys Phe Pro Tyr Thr Gly Thr Asp Ser Pro Cys Lys Met Lys Glu Asp
                325                 330                 335     
Cys Phe Arg Tyr Tyr Ser Ser Glu Tyr His Tyr Val Gly Gly Phe Tyr
            340                 345                 350         
Gly Gly Cys Asn Glu Ala Leu Met Lys Leu Glu Leu Val His His Gly
        355                 360                 365             
Pro Met Ala Val Ala Phe Glu Val Tyr Asp Asp Phe Leu His Tyr Lys
    370                 375                 380                 
Lys Gly Ile Tyr His His Thr Gly Leu Arg Asp Pro Phe Asn Pro Phe
385                 390                 395                 400 
Glu Leu Thr Asn His Ala Val Leu Leu Val Gly Tyr Gly Thr Asp Ser
                405                 410                 415     
Ala Ser Gly Met Asp Tyr Trp Ile Val Lys Asn Ser Trp Gly Thr Gly
            420                 425                 430         
Trp Gly Glu Asn Gly Tyr Phe Arg Ile Arg Arg Gly Thr Asp Glu Cys
        435                 440                 445             
Ala Ile Glu Ser Ile Ala Val Ala Ala Thr Pro Ile Pro Lys Leu
    450                 455                 460             


<210> 180
<211> 343
<212> PRT
<213> Homo sapiens

<220> 
<223> Cathepsin C mature

<220> 
<223> Dipeptidyl-peptidase 1 exclusion domain chain 1-110

<220> 
<223> Dipeptidyl-peptidase 1 heavy chain 111-274

<220> 
<223> Dipeptidyl-peptidase 1 light chain 275-343

<400> 180
Asp Thr Pro Ala Asn Cys Thr Tyr Leu Asp Leu Leu Gly Thr Trp Val
 1               5                  10                  15      
Phe Gln Val Gly Ser Ser Gly Ser Gln Arg Asp Val Asn Cys Ser Val
            20                  25                  30          
Met Gly Pro Gln Glu Lys Lys Val Val Val Tyr Leu Gln Lys Leu Asp
        35                  40                  45              
Thr Ala Tyr Asp Asp Leu Gly Asn Ser Gly His Phe Thr Ile Ile Tyr
    50                  55                  60                  
Asn Gln Gly Phe Glu Ile Val Leu Asn Asp Tyr Lys Trp Phe Ala Phe
65                  70                  75                  80  
Phe Lys Tyr Lys Glu Glu Gly Ser Lys Val Thr Thr Tyr Cys Asn Glu
                85                  90                  95      
Thr Met Thr Gly Trp Val His Asp Val Leu Gly Arg Asn Trp Leu Pro
            100                 105                 110         
Thr Ser Trp Asp Trp Arg Asn Val His Gly Ile Asn Phe Val Ser Pro
        115                 120                 125             
Val Arg Asn Gln Ala Ser Cys Gly Ser Cys Tyr Ser Phe Ala Ser Met
    130                 135                 140                 
Gly Met Leu Glu Ala Arg Ile Arg Ile Leu Thr Asn Asn Ser Gln Thr
145                 150                 155                 160 
Pro Ile Leu Ser Pro Gln Glu Val Val Ser Cys Ser Gln Tyr Ala Gln
                165                 170                 175     
Gly Cys Glu Gly Gly Phe Pro Tyr Leu Ile Ala Gly Lys Tyr Ala Gln

            180                 185                 190         
Asp Phe Gly Leu Val Glu Glu Ala Cys Phe Pro Tyr Thr Gly Thr Asp
        195                 200                 205             
Ser Pro Cys Lys Met Lys Glu Asp Cys Phe Arg Tyr Tyr Ser Ser Glu
    210                 215                 220                 
Tyr His Tyr Val Gly Gly Phe Tyr Gly Gly Cys Asn Glu Ala Leu Met
225                 230                 235                 240 
Lys Leu Glu Leu Val His His Gly Pro Met Ala Val Ala Phe Glu Val
                245                 250                 255     
Tyr Asp Asp Phe Leu His Tyr Lys Lys Gly Ile Tyr His His Thr Gly
            260                 265                 270         
Leu Arg Asp Pro Phe Asn Pro Phe Glu Leu Thr Asn His Ala Val Leu
        275                 280                 285             
Leu Val Gly Tyr Gly Thr Asp Ser Ala Ser Gly Met Asp Tyr Trp Ile
    290                 295                 300                 
Val Lys Asn Ser Trp Gly Thr Gly Trp Gly Glu Asn Gly Tyr Phe Arg
305                 310                 315                 320 
Ile Arg Arg Gly Thr Asp Glu Cys Ala Ile Glu Ser Ile Ala Val Ala
                325                 330                 335     
Ala Thr Pro Ile Pro Lys Leu
            340             


<210> 181
<211> 2032
<212> DNA
<213> Homo sapiens

<220> 
<223> cathepsin F

<400> 181
ggaggactca ggccccgctg gccgcgggct cggtacccgg tgggtcggtg gagcgtctgt 60
tgggtccggg ccgccggctt cgccctcgcc atggcgccct ggctgcagct cctgtcgctg 120
ctggggctgc tcccgggcgc agtggccgcc cccgcccagc cccgagccgc cagctttcag 180
gcctgggggc cgccgtcccc ggagctgctg gcgcccaccc gcttcgcgct ggagatgttc 240
aaccgcggcc gggctgcggg gacgcgggcc gtgctgggcc ttgtgcgcgg ccgcgtccgc 300
cgggcgggtc aggggtcgct gtactccctg gaggccaccc tggaggagcc accctgcaac 360
gaccccatgg tgtgccggct ccccgtgtcc aagaaaaccc tgctctgcag cttccaagtc 420
ctggatgagc tcggaagaca cgtgctgctg cggaaggact gtggcccagt ggacaccaag 480
gttccaggtg ctggggagcc caagtcagcc ttcactcagg gctcagccat gatttcttct 540
ctgtcccaaa accatccaga caacagaaac gagactttca gctcagtcat ttccctgttg 600
aatgaggatc ccctgtccca ggacttgcct gtgaagatgg cttcaatctt caagaacttt 660
gtcattacct ataaccggac atatgagtca aaggaagaag cccggtggcg cctgtccgtc 720
tttgtcaata acatggtgcg agcacagaag atccaggccc tggaccgtgg cacagctcag 780
tatggagtca ccaagttcag tgatctcaca gaggaggagt tccgcactat ctacctgaat 840
actctcctga ggaaagagcc tggcaacaag atgaagcaag ccaagtctgt gggtgacctc 900
gccccacctg aatgggactg gaggagtaag ggggctgtca caaaagtcaa agaccagggc 960
atgtgtggct cctgctgggc cttctcagtc acaggcaatg tggagggcca gtggtttctc 1020
aaccagggga ccctgctctc cctctctgaa caggagctct tggactgtga caagatggac 1080
aaggcctgca tgggcggctt gccctccaat gcctactcgg ccataaagaa tttgggaggg 1140
ctggagacag aggatgacta cagctaccag ggtcacatgc agtcctgcaa cttctcagca 1200
gagaaggcca aggtctacat caatgactcc gtggagctga gccagaacga gcagaagctg 1260
gcagcctggc tggccaagag aggcccaatc tccgtggcca tcaatgcctt tggcatgcag 1320
ttttaccgcc acgggatctc ccgccctctc cggcccctct gcagcccttg gctcattgac 1380
catgcggtgt tgcttgtggg ctacggcaac cgctctgacg ttcccttttg ggccatcaag 1440
aacagctggg gcactgactg gggtgagaag ggttactact acttgcatcg tgggtccggg 1500
gcctgtggcg tgaacaccat ggccagctcg gcggtggtgg actgaagagg ggcccccagc 1560
tcgggacctg gtgctgatca gagtggctgc tgccccagcc tgacatgtgt ccaggcccct 1620
ccccgggagg tacagctggc agagggaaag gcactgggta cctcagggtg agcagagggc 1680
actgggctgg ggcacagccc ctgcttccct gcaccccatt cccaccctga agttctgcac 1740
ctgcaccttt gttgaattgt ggtagcttag gaggatgtcg gggtgaaggg tggtatcttg 1800
gcagttgaag ctggggcaag aactctgggc ttgggtaatg agcaggaaga aaattttctg 1860
atcttaagcc cagctctgtt ctgcccccgc tttcctctgt ttgatactat aaattttctg 1920
gttcccttgg atttagggat agtgtccctc tccatgtcca ggaaacttgt aaccaccctt 1980
ttctaacagc aataaagagg tgtccttgtc ccgaaaaaaa aaaaaaaaaa aa         2032

<210> 182
<211> 484
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin F precursor

<400> 182
Met Ala Pro Trp Leu Gln Leu Leu Ser Leu Leu Gly Leu Leu Pro Gly
 1               5                  10                  15      
Ala Val Ala Ala Pro Ala Gln Pro Arg Ala Ala Ser Phe Gln Ala Trp
            20                  25                  30          
Gly Pro Pro Ser Pro Glu Leu Leu Ala Pro Thr Arg Phe Ala Leu Glu
        35                  40                  45              
Met Phe Asn Arg Gly Arg Ala Ala Gly Thr Arg Ala Val Leu Gly Leu
    50                  55                  60                  
Val Arg Gly Arg Val Arg Arg Ala Gly Gln Gly Ser Leu Tyr Ser Leu
65                  70                  75                  80  
Glu Ala Thr Leu Glu Glu Pro Pro Cys Asn Asp Pro Met Val Cys Arg
                85                  90                  95      
Leu Pro Val Ser Lys Lys Thr Leu Leu Cys Ser Phe Gln Val Leu Asp
            100                 105                 110         
Glu Leu Gly Arg His Val Leu Leu Arg Lys Asp Cys Gly Pro Val Asp
        115                 120                 125             
Thr Lys Val Pro Gly Ala Gly Glu Pro Lys Ser Ala Phe Thr Gln Gly
    130                 135                 140                 
Ser Ala Met Ile Ser Ser Leu Ser Gln Asn His Pro Asp Asn Arg Asn
145                 150                 155                 160 
Glu Thr Phe Ser Ser Val Ile Ser Leu Leu Asn Glu Asp Pro Leu Ser
                165                 170                 175     
Gln Asp Leu Pro Val Lys Met Ala Ser Ile Phe Lys Asn Phe Val Ile
            180                 185                 190         
Thr Tyr Asn Arg Thr Tyr Glu Ser Lys Glu Glu Ala Arg Trp Arg Leu
        195                 200                 205             
Ser Val Phe Val Asn Asn Met Val Arg Ala Gln Lys Ile Gln Ala Leu
    210                 215                 220                 
Asp Arg Gly Thr Ala Gln Tyr Gly Val Thr Lys Phe Ser Asp Leu Thr
225                 230                 235                 240 
Glu Glu Glu Phe Arg Thr Ile Tyr Leu Asn Thr Leu Leu Arg Lys Glu
                245                 250                 255     
Pro Gly Asn Lys Met Lys Gln Ala Lys Ser Val Gly Asp Leu Ala Pro
            260                 265                 270         
Pro Glu Trp Asp Trp Arg Ser Lys Gly Ala Val Thr Lys Val Lys Asp
        275                 280                 285             
Gln Gly Met Cys Gly Ser Cys Trp Ala Phe Ser Val Thr Gly Asn Val
    290                 295                 300                 
Glu Gly Gln Trp Phe Leu Asn Gln Gly Thr Leu Leu Ser Leu Ser Glu
305                 310                 315                 320 
Gln Glu Leu Leu Asp Cys Asp Lys Met Asp Lys Ala Cys Met Gly Gly
                325                 330                 335     
Leu Pro Ser Asn Ala Tyr Ser Ala Ile Lys Asn Leu Gly Gly Leu Glu
            340                 345                 350         
Thr Glu Asp Asp Tyr Ser Tyr Gln Gly His Met Gln Ser Cys Asn Phe
        355                 360                 365             
Ser Ala Glu Lys Ala Lys Val Tyr Ile Asn Asp Ser Val Glu Leu Ser
    370                 375                 380                 
Gln Asn Glu Gln Lys Leu Ala Ala Trp Leu Ala Lys Arg Gly Pro Ile
385                 390                 395                 400 
Ser Val Ala Ile Asn Ala Phe Gly Met Gln Phe Tyr Arg His Gly Ile
                405                 410                 415     
Ser Arg Pro Leu Arg Pro Leu Cys Ser Pro Trp Leu Ile Asp His Ala
            420                 425                 430         
Val Leu Leu Val Gly Tyr Gly Asn Arg Ser Asp Val Pro Phe Trp Ala
        435                 440                 445             
Ile Lys Asn Ser Trp Gly Thr Asp Trp Gly Glu Lys Gly Tyr Tyr Tyr
    450                 455                 460                 
Leu His Arg Gly Ser Gly Ala Cys Gly Val Asn Thr Met Ala Ser Ser
465                 470                 475                 480 
Ala Val Val Asp
                


<210> 183
<211> 214
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin F mature

<400> 183
Ala Pro Pro Glu Trp Asp Trp Arg Ser Lys Gly Ala Val Thr Lys Val
 1               5                  10                  15      
Lys Asp Gln Gly Met Cys Gly Ser Cys Trp Ala Phe Ser Val Thr Gly
            20                  25                  30          
Asn Val Glu Gly Gln Trp Phe Leu Asn Gln Gly Thr Leu Leu Ser Leu
        35                  40                  45              
Ser Glu Gln Glu Leu Leu Asp Cys Asp Lys Met Asp Lys Ala Cys Met
    50                  55                  60                  
Gly Gly Leu Pro Ser Asn Ala Tyr Ser Ala Ile Lys Asn Leu Gly Gly
65                  70                  75                  80  
Leu Glu Thr Glu Asp Asp Tyr Ser Tyr Gln Gly His Met Gln Ser Cys
                85                  90                  95      
Asn Phe Ser Ala Glu Lys Ala Lys Val Tyr Ile Asn Asp Ser Val Glu
            100                 105                 110         
Leu Ser Gln Asn Glu Gln Lys Leu Ala Ala Trp Leu Ala Lys Arg Gly
        115                 120                 125             
Pro Ile Ser Val Ala Ile Asn Ala Phe Gly Met Gln Phe Tyr Arg His
    130                 135                 140                 
Gly Ile Ser Arg Pro Leu Arg Pro Leu Cys Ser Pro Trp Leu Ile Asp
145                 150                 155                 160 
His Ala Val Leu Leu Val Gly Tyr Gly Asn Arg Ser Asp Val Pro Phe
                165                 170                 175     
Trp Ala Ile Lys Asn Ser Trp Gly Thr Asp Trp Gly Glu Lys Gly Tyr
            180                 185                 190         
Tyr Tyr Leu His Arg Gly Ser Gly Ala Cys Gly Val Asn Thr Met Ala
        195                 200                 205             
Ser Ser Ala Val Val Asp
    210                 


<210> 184
<211> 2943
<212> DNA
<213> Homo sapiens

<220> 
<223> cathepsin O

<400> 184
ccgaaagaga aaacaggccg cgcgggcggc agaggagccg ggcgccgcaa tggacgtgcg 60
ggcgctgccg tggctgccgt ggctgctgtg gctgctgtgc cggggcggcg gcgatgcgga 120
ctcccgcgcc cccttcaccc cgacctggcc gcggagccgc gagcgtgaag ccgccgcctt 180
ccgggaaagt cttaatagac atcgatactt gaattcttta tttcccagtg aaaactccac 240
cgccttctat ggaataaatc agttttccta tttgtttcct gaagagttta aagccattta 300
tttaagaagc aaaccttcca agtttcccag atactcagca gaagtacata tgtccatccc 360
caatgtgtct ttgccgttaa gatttgactg gagggacaag caggttgtga cacaagtgag 420
aaaccagcag atgtgtggag gatgctgggc cttcagcgtg gtgggggcag tggaatctgc 480
ttatgcaata aaggggaagc ccctggaaga cctaagtgtc cagcaggtca ttgactgttc 540
gtataataat tatggctgca atggaggctc tactctcaat gctttgaact ggttaaacaa 600
gatgcaagta aaactggtga aagattcaga atatcctttt aaagcacaaa atggtctgtg 660
ccattacttt tctggttcac attctggatt ttcaatcaaa ggttattctg catatgactt 720
cagtgaccaa gaagatgaaa tggcaaaagc acttcttacc tttggccctt tggtagtcat 780
agtagatgca gtgagctggc aagattatct gggaggcatt atacagcatc actgctctag 840
tggagaagca aatcatgcag ttctcataac tgggtttgat aaaacaggaa gcactccata 900
ttggattgtg cggaattcct ggggaagttc ttggggagta gatggttatg cccatgtcaa 960
aatgggaagt aatgtttgtg gtattgcaga ttccgtttct tctatatttg tgtgacatgt 1020
tgggcagatc aagagacagc tacaaaaatg aaggttttca taatgcaatg taacatagta 1080
cttcaaagta ttattcaact tcaagtttca gcaactacct acaaaagatt ctaaggccta 1140
gtagtattta aactaagttt cagaatgttc ccttcttgta gagagatgga caaccaaagt 1200
cagtgggaca aactccagca cagaagcctg cgaggaagcc tatggaatag tttcctgtcc 1260
tgagacgaaa ttcagattag gagatatttt aggcccctgc aactggggaa ggctactgtt 1320
tgtttttgtt tgcttattat ttatttgttt gtttattgtg agatatttca ggtgggatca 1380
aagaggtcat aagaatttat tttcttttgt ggggtgtaac tactagcttt agattacccc 1440
tatacacaag aatggccaac ctaaaattat gtgtgtcttg tacagttagt tatattagca 1500
gccctctgag atggcgtatc tatcggaagg atttcaaaca ccaattgctt tacctgaaca 1560
aatggtgctt accctttgaa cagcagagtg accacgtaga aggaaggaaa agggcaaaat 1620
cgcttcagtt aaactgaaat taaatgaaca ataaggcaac tatataagta acttctagta 1680
gcattgcctg agagacaaat tattgtttga taattttcat tgtgaatagg aatccaatag 1740
atcatattgc ttactttgtt ctttttatac tatagaataa tattttgttc tctagtatat 1800
caaaatacca aaatattatc tcatattttc tccctctttc tcttactctt taccaagttt 1860
tcctggtggc ttggcttccc tgactaaaga attaagtctc atttttactt tccatttcta 1920
ttttcttacc acttggttgg ctccctttgt ctctgtacct ttaccaacat taggatctca 1980
cctctttctt cctcccttaa ttcataagca ccactcctat caaagtccca tctcttaacc 2040
ctgggtatca aacaaactgt gagttttcca gaatctgttt cccagttttc ccctcagctt 2100
tcctggtctc ccatccgaac tgcttctttg tgcacctctt gttctttctc ttggctccca 2160
gtcttgattc ctgtgatcac tcttgcatca ctaattgcac aagtgatttc aggtgcaatt 2220
ctgattagcc tgcgtccaca cagtgatcga tgatcctatg tgcctagaaa ggacactgtg 2280
tgctgctcat gacctgcaac aggaaaaaag ccatttcttg ttagcagtgt aagaacctta 2340
gagcaaagga gttgaccttc tgattgaata taagcacaac catattaaat gaatcaatac 2400
aagaaaatta tttctgatac tatgtatgta catatttctt ctctaaaatg tatcattctt 2460
ttctaatgta tatgatctaa caaaaatgaa acatgaaatg cagtagcaac cactaaaaaa 2520
aaaaattcaa ggacatctaa ctttttctct cacttttgcc ctttgtttat ccttccctgt 2580
gattagataa acaaaataaa aaacaaaatg ctgtatttct cttcttacgc cagtcagaac 2640
caatccgaaa agaatgtgtg ttgactcagg tttggagtta tttcaggaag acagatattg 2700
accttttaat tgataaatat tcttattatc ctggaatgcc agaaaagaac tatgtcctgc 2760
ttgtctagtt tgtattcgct gactttctat gtgatataga tgcatttgta atactctttt 2820
tcaagtgcta aaggatttct aaaatttcaa actgattaat atgtttctgc tgttctggat 2880
tttgatgaca tttacaataa aacaacctac atttgacttt ggtttaaaaa gaaaaaaaaa 2940
aaa                                                               2943

<210> 185
<211> 321
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin O precursor

<400> 185
Met Asp Val Arg Ala Leu Pro Trp Leu Pro Trp Leu Leu Trp Leu Leu
 1               5                  10                  15      
Cys Arg Gly Gly Gly Asp Ala Asp Ser Arg Ala Pro Phe Thr Pro Thr
            20                  25                  30          
Trp Pro Arg Ser Arg Glu Arg Glu Ala Ala Ala Phe Arg Glu Ser Leu
        35                  40                  45              
Asn Arg His Arg Tyr Leu Asn Ser Leu Phe Pro Ser Glu Asn Ser Thr
    50                  55                  60                  
Ala Phe Tyr Gly Ile Asn Gln Phe Ser Tyr Leu Phe Pro Glu Glu Phe
65                  70                  75                  80  
Lys Ala Ile Tyr Leu Arg Ser Lys Pro Ser Lys Phe Pro Arg Tyr Ser
                85                  90                  95      
Ala Glu Val His Met Ser Ile Pro Asn Val Ser Leu Pro Leu Arg Phe
            100                 105                 110         
Asp Trp Arg Asp Lys Gln Val Val Thr Gln Val Arg Asn Gln Gln Met
        115                 120                 125             
Cys Gly Gly Cys Trp Ala Phe Ser Val Val Gly Ala Val Glu Ser Ala
    130                 135                 140                 
Tyr Ala Ile Lys Gly Lys Pro Leu Glu Asp Leu Ser Val Gln Gln Val
145                 150                 155                 160 
Ile Asp Cys Ser Tyr Asn Asn Tyr Gly Cys Asn Gly Gly Ser Thr Leu
                165                 170                 175     
Asn Ala Leu Asn Trp Leu Asn Lys Met Gln Val Lys Leu Val Lys Asp
            180                 185                 190         
Ser Glu Tyr Pro Phe Lys Ala Gln Asn Gly Leu Cys His Tyr Phe Ser
        195                 200                 205             
Gly Ser His Ser Gly Phe Ser Ile Lys Gly Tyr Ser Ala Tyr Asp Phe
    210                 215                 220                 
Ser Asp Gln Glu Asp Glu Met Ala Lys Ala Leu Leu Thr Phe Gly Pro
225                 230                 235                 240 
Leu Val Val Ile Val Asp Ala Val Ser Trp Gln Asp Tyr Leu Gly Gly
                245                 250                 255     
Ile Ile Gln His His Cys Ser Ser Gly Glu Ala Asn His Ala Val Leu
            260                 265                 270         
Ile Thr Gly Phe Asp Lys Thr Gly Ser Thr Pro Tyr Trp Ile Val Arg
        275                 280                 285             
Asn Ser Trp Gly Ser Ser Trp Gly Val Asp Gly Tyr Ala His Val Lys
    290                 295                 300                 
Met Gly Ser Asn Val Cys Gly Ile Ala Asp Ser Val Ser Ser Ile Phe
305                 310                 315                 320 
Val
    


<210> 186
<211> 214
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin O mature

<400> 186
Leu Pro Leu Arg Phe Asp Trp Arg Asp Lys Gln Val Val Thr Gln Val
 1               5                  10                  15      
Arg Asn Gln Gln Met Cys Gly Gly Cys Trp Ala Phe Ser Val Val Gly
            20                  25                  30          
Ala Val Glu Ser Ala Tyr Ala Ile Lys Gly Lys Pro Leu Glu Asp Leu
        35                  40                  45              
Ser Val Gln Gln Val Ile Asp Cys Ser Tyr Asn Asn Tyr Gly Cys Asn
    50                  55                  60                  
Gly Gly Ser Thr Leu Asn Ala Leu Asn Trp Leu Asn Lys Met Gln Val
65                  70                  75                  80  
Lys Leu Val Lys Asp Ser Glu Tyr Pro Phe Lys Ala Gln Asn Gly Leu
                85                  90                  95      
Cys His Tyr Phe Ser Gly Ser His Ser Gly Phe Ser Ile Lys Gly Tyr
            100                 105                 110         
Ser Ala Tyr Asp Phe Ser Asp Gln Glu Asp Glu Met Ala Lys Ala Leu
        115                 120                 125             
Leu Thr Phe Gly Pro Leu Val Val Ile Val Asp Ala Val Ser Trp Gln
    130                 135                 140                 
Asp Tyr Leu Gly Gly Ile Ile Gln His His Cys Ser Ser Gly Glu Ala
145                 150                 155                 160 
Asn His Ala Val Leu Ile Thr Gly Phe Asp Lys Thr Gly Ser Thr Pro
                165                 170                 175     
Tyr Trp Ile Val Arg Asn Ser Trp Gly Ser Ser Trp Gly Val Asp Gly
            180                 185                 190         
Tyr Ala His Val Lys Met Gly Ser Asn Val Cys Gly Ile Ala Asp Ser
        195                 200                 205             
Val Ser Ser Ile Phe Val
    210                 


<210> 187
<211> 1496
<212> DNA
<213> Homo sapiens

<220> 
<223> cathepsin V

<400> 187
gctctaagcg cccggggccc cgcccagtgg ccggcacagc caatcgcagc gcgggaaggc 60
ggtgggggcg gggaaggccg cctggaaact taaatcccga ggcgggcgaa cctgcaccag 120
accgcggacg tctgtaatct cagaggcttg tttgctgagg gtgcctgcgc agctgcgacg 180
gctgctggtt ttgaaacatg aatctttcgc tcgtcctggc tgccttttgc ttgggaatag 240
cctccgctgt tccaaaattt gaccaaaatt tggatacaaa gtggtaccag tggaaggcaa 300
cacacagaag attatatggc gcgaatgaag aaggatggag gagagcagtg tgggaaaaga 360
atatgaaaat gattgaactg cacaatgggg aatacagcca agggaaacat ggcttcacaa 420
tggccatgaa tgcttttggt gacatgacca atgaagaatt caggcagatg atgggttgct 480
ttcgaaacca gaaattcagg aaggggaaag tgttccgtga gcctctgttt cttgatcttc 540
ccaaatctgt ggattggaga aagaaaggct acgtgacgcc agtgaagaat cagaaacagt 600
gtggttcttg ttgggctttt agtgcgactg gtgctcttga aggacagatg ttccggaaaa 660
ctgggaaact tgtctcactg agcgagcaga atctggtgga ctgttcgcgt cctcaaggca 720
atcagggctg caatggtggc ttcatggcta gggccttcca gtatgtcaag gagaacggag 780
gcctggactc tgaggaatcc tatccatatg tagcagtgga tgaaatctgt aagtacagac 840
ctgagaattc tgttgctaat gacactggct tcacagtggt cgcacctgga aaggagaagg 900
ccctgatgaa agcagtcgca actgtggggc ccatctccgt tgctatggat gcaggccatt 960
cgtccttcca gttctacaaa tcaggcattt attttgaacc agactgcagc agcaaaaacc 1020
tggatcatgg tgttctggtg gttggctacg gctttgaagg agcaaattcg aataacagca 1080
agtattggct cgtcaaaaac agctggggtc cagaatgggg ctcgaatggc tatgtaaaaa 1140
tagccaaaga caagaacaac cactgtggaa tcgccacagc agccagctac cccaatgtgt 1200
gagctgatgg atggtgagga ggaaggactt aaggacagca tgtctgggga aattttatct 1260
tgaaactgac caaacgctta ttgtgtaaga taaaccagtt gaatcattga ggatccaagt 1320
tgagatttta attctgtgac atttttacaa gggtaaaatg ttaccactac tttaattatt 1380
gttatacaca gctttatgat atcaaagact cattgcttaa ttctaagact tttgaatttt 1440
cattttttaa aaagatgtac aaaacagttt gaaataaatt ttaattcgta tataaa     1496

<210> 188
<211> 334
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin V precursor

<400> 188
Met Asn Leu Ser Leu Val Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser
 1               5                  10                  15      
Ala Val Pro Lys Phe Asp Gln Asn Leu Asp Thr Lys Trp Tyr Gln Trp
            20                  25                  30          
Lys Ala Thr His Arg Arg Leu Tyr Gly Ala Asn Glu Glu Gly Trp Arg
        35                  40                  45              
Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gly
    50                  55                  60                  
Glu Tyr Ser Gln Gly Lys His Gly Phe Thr Met Ala Met Asn Ala Phe
65                  70                  75                  80  
Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Met Met Gly Cys Phe Arg
                85                  90                  95      
Asn Gln Lys Phe Arg Lys Gly Lys Val Phe Arg Glu Pro Leu Phe Leu
            100                 105                 110         
Asp Leu Pro Lys Ser Val Asp Trp Arg Lys Lys Gly Tyr Val Thr Pro
        115                 120                 125             
Val Lys Asn Gln Lys Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr
    130                 135                 140                 
Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser
145                 150                 155                 160 
Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Arg Pro Gln Gly Asn Gln
                165                 170                 175     
Gly Cys Asn Gly Gly Phe Met Ala Arg Ala Phe Gln Tyr Val Lys Glu
            180                 185                 190         
Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Val Ala Val Asp
        195                 200                 205             
Glu Ile Cys Lys Tyr Arg Pro Glu Asn Ser Val Ala Asn Asp Thr Gly
    210                 215                 220                 
Phe Thr Val Val Ala Pro Gly Lys Glu Lys Ala Leu Met Lys Ala Val
225                 230                 235                 240 
Ala Thr Val Gly Pro Ile Ser Val Ala Met Asp Ala Gly His Ser Ser
                245                 250                 255     
Phe Gln Phe Tyr Lys Ser Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser
            260                 265                 270         
Lys Asn Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly
        275                 280                 285             
Ala Asn Ser Asn Asn Ser Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly
    290                 295                 300                 
Pro Glu Trp Gly Ser Asn Gly Tyr Val Lys Ile Ala Lys Asp Lys Asn
305                 310                 315                 320 
Asn His Cys Gly Ile Ala Thr Ala Ala Ser Tyr Pro Asn Val
                325                 330                 


<210> 189
<211> 221
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin V mature

<400> 189
Leu Pro Lys Ser Val Asp Trp Arg Lys Lys Gly Tyr Val Thr Pro Val
 1               5                  10                  15      
Lys Asn Gln Lys Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr Gly
            20                  25                  30          
Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser Leu
        35                  40                  45              
Ser Glu Gln Asn Leu Val Asp Cys Ser Arg Pro Gln Gly Asn Gln Gly
    50                  55                  60                  
Cys Asn Gly Gly Phe Met Ala Arg Ala Phe Gln Tyr Val Lys Glu Asn
65                  70                  75                  80  
Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Val Ala Val Asp Glu
                85                  90                  95      
Ile Cys Lys Tyr Arg Pro Glu Asn Ser Val Ala Asn Asp Thr Gly Phe
            100                 105                 110         
Thr Val Val Ala Pro Gly Lys Glu Lys Ala Leu Met Lys Ala Val Ala
        115                 120                 125             
Thr Val Gly Pro Ile Ser Val Ala Met Asp Ala Gly His Ser Ser Phe
    130                 135                 140                 
Gln Phe Tyr Lys Ser Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Lys
145                 150                 155                 160 
Asn Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly Ala
                165                 170                 175     

Asn Ser Asn Asn Ser Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Pro
            180                 185                 190         
Glu Trp Gly Ser Asn Gly Tyr Val Lys Ile Ala Lys Asp Lys Asn Asn
        195                 200                 205             
His Cys Gly Ile Ala Thr Ala Ala Ser Tyr Pro Asn Val
    210                 215                 220     


<210> 190
<211> 2048
<212> DNA
<213> Homo sapiens

<220> 
<223> legumain

<400> 190
gcacagtggc ccttaagcga ggagcggcgg cgcccgcagc aatcacagca gtgccgacgt 60
cgtgggtgtt tggtgtgagg ctgcgagccg ccgcgagttc tcacggtccc gccggcgcca 120
ccaccgcggt cactcaccgc cgccgccgcc accactgcca ccacggtcgc ctgccacagg 180
tgtctgcaat tgaactccaa ggtgcagaat ggtttggaaa gtagctgtat tcctcagtgt 240
ggccctgggc attggtgccg ttcctataga tgatcctgaa gatggaggca agcactgggt 300
ggtgatcgtg gcaggttcaa atggctggta taattatagg caccaggcag acgcgtgcca 360
tgcctaccag atcattcacc gcaatgggat tcctgacgaa cagatcgttg tgatgatgta 420
cgatgacatt gcttactctg aagacaatcc cactccagga attgtgatca acaggcccaa 480
tggcacagat gtctatcagg gagtcccgaa ggactacact ggagaggatg ttaccccaca 540
aaatttcctt gctgtgttga gaggcgatgc agaagcagtg aagggcatag gatccggcaa 600
agtcctgaag agtggccccc aggatcacgt gttcatttac ttcactgacc atggatctac 660
tggaatactg gtttttccca atgaagatct tcatgtaaag gacctgaatg agaccatcca 720
ttacatgtac aaacacaaaa tgtaccgaaa gatggtgttc tacattgaag cctgtgagtc 780
tgggtccatg atgaaccacc tgccggataa catcaatgtt tatgcaacta ctgctgccaa 840
ccccagagag tcgtcctacg cctgttacta tgatgagaag aggtccacgt acctggggga 900
ctggtacagc gtcaactgga tggaagattc ggacgtggaa gatctgacta aagagaccct 960
gcacaagcag taccacctgg taaaatcgca caccaacacc agccacgtca tgcagtatgg 1020
aaacaaaaca atctccacca tgaaagtgat gcagtttcag ggtatgaaac gcaaagccag 1080
ttctcccgtc cccctacctc cagtcacaca ccttgacctc acccccagcc ctgatgtgcc 1140
tctcaccatc atgaaaagga aactgatgaa caccaatgat ctggaggagt ccaggcagct 1200
cacggaggag atccagcggc atctggatgc caggcacctc attgagaagt cagtgcgtaa 1260
gatcgtctcc ttgctggcag cgtccgaggc tgaggtggag cagctcctgt ccgagagagc 1320
cccgctcacg gggcacagct gctacccaga ggccctgctg cacttccgga cccactgctt 1380
caactggcac tcccccacgt acgagtatgc gttgagacat ttgtacgtgc tggtcaacct 1440
ttgtgagaag ccgtatccgc ttcacaggat aaaattgtcc atggaccacg tgtgccttgg 1500
tcactactga agagctgcct cctggaagct tttccaagtg tgagcgcccc accgactgtg 1560
tgctgatcag agactggaga ggtggagtga gaagtctccg ctgctcgggc cctcctgggg 1620
agcccccgct ccagggctcg ctccaggacc ttcttcacaa gatgacttgc tcgctgttac 1680
ctgcttcccc agtcttttct gaaaaactac aaattagggt gggaaaagct ctgtattgag 1740
aagggtcata tttgctttct aggaggtttg ttgttttgcc tgttagtttt gaggagcagg 1800
aagctcatgg gggcttctgt agcccctctc aaaaggagtc tttattctga gaatttgaag 1860
ctgaaacctc tttaaatctt cagaatgatt ttattgaaga gggccgcaag ccccaaatgg 1920
aaaactgttt ttagaaaata tgatgatttt tgattgcttt tgtatttaat tctgcaggtg 1980
ttcaagtctt aaaaaataaa gatttataac agaacccaaa aaaaaaaaaa aaaaaaaaaa 2040
aaaaaaaa                                                          2048

<210> 191
<211> 433
<212> PRT
<213> Homo sapiens

<220> 
<223> legumain precursor

<400> 191
Met Val Trp Lys Val Ala Val Phe Leu Ser Val Ala Leu Gly Ile Gly
 1               5                  10                  15      
Ala Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val
            20                  25                  30          
Ile Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp
        35                  40                  45              
Ala Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu
    50                  55                  60                  
Gln Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu Asp Asn
65                  70                  75                  80  
Pro Thr Pro Gly Ile Val Ile Asn Arg Pro Asn Gly Thr Asp Val Tyr
                85                  90                  95      
Gln Gly Val Pro Lys Asp Tyr Thr Gly Glu Asp Val Thr Pro Gln Asn
            100                 105                 110         
Phe Leu Ala Val Leu Arg Gly Asp Ala Glu Ala Val Lys Gly Ile Gly
        115                 120                 125             
Ser Gly Lys Val Leu Lys Ser Gly Pro Gln Asp His Val Phe Ile Tyr
    130                 135                 140                 
Phe Thr Asp His Gly Ser Thr Gly Ile Leu Val Phe Pro Asn Glu Asp
145                 150                 155                 160 
Leu His Val Lys Asp Leu Asn Glu Thr Ile His Tyr Met Tyr Lys His
                165                 170                 175     
Lys Met Tyr Arg Lys Met Val Phe Tyr Ile Glu Ala Cys Glu Ser Gly
            180                 185                 190         
Ser Met Met Asn His Leu Pro Asp Asn Ile Asn Val Tyr Ala Thr Thr
        195                 200                 205             
Ala Ala Asn Pro Arg Glu Ser Ser Tyr Ala Cys Tyr Tyr Asp Glu Lys
    210                 215                 220                 
Arg Ser Thr Tyr Leu Gly Asp Trp Tyr Ser Val Asn Trp Met Glu Asp
225                 230                 235                 240 
Ser Asp Val Glu Asp Leu Thr Lys Glu Thr Leu His Lys Gln Tyr His
                245                 250                 255     
Leu Val Lys Ser His Thr Asn Thr Ser His Val Met Gln Tyr Gly Asn
            260                 265                 270         
Lys Thr Ile Ser Thr Met Lys Val Met Gln Phe Gln Gly Met Lys Arg
        275                 280                 285             
Lys Ala Ser Ser Pro Val Pro Leu Pro Pro Val Thr His Leu Asp Leu
    290                 295                 300                 
Thr Pro Ser Pro Asp Val Pro Leu Thr Ile Met Lys Arg Lys Leu Met
305                 310                 315                 320 
Asn Thr Asn Asp Leu Glu Glu Ser Arg Gln Leu Thr Glu Glu Ile Gln
                325                 330                 335     
Arg His Leu Asp Ala Arg His Leu Ile Glu Lys Ser Val Arg Lys Ile
            340                 345                 350         
Val Ser Leu Leu Ala Ala Ser Glu Ala Glu Val Glu Gln Leu Leu Ser
        355                 360                 365             
Glu Arg Ala Pro Leu Thr Gly His Ser Cys Tyr Pro Glu Ala Leu Leu
    370                 375                 380                 
His Phe Arg Thr His Cys Phe Asn Trp His Ser Pro Thr Tyr Glu Tyr
385                 390                 395                 400 
Ala Leu Arg His Leu Tyr Val Leu Val Asn Leu Cys Glu Lys Pro Tyr
                405                 410                 415     
Pro Leu His Arg Ile Lys Leu Ser Met Asp His Val Cys Leu Gly His
            420                 425                 430         
Tyr
    


<210> 192
<211> 306
<212> PRT
<213> Homo sapiens

<220> 
<223> legumain mature

<400> 192
Val Pro Ile Asp Asp Pro Glu Asp Gly Gly Lys His Trp Val Val Ile
 1               5                  10                  15      
Val Ala Gly Ser Asn Gly Trp Tyr Asn Tyr Arg His Gln Ala Asp Ala
            20                  25                  30          
Cys His Ala Tyr Gln Ile Ile His Arg Asn Gly Ile Pro Asp Glu Gln
        35                  40                  45              
Ile Val Val Met Met Tyr Asp Asp Ile Ala Tyr Ser Glu Asp Asn Pro
    50                  55                  60                  
Thr Pro Gly Ile Val Ile Asn Arg Pro Asn Gly Thr Asp Val Tyr Gln
65                  70                  75                  80  
Gly Val Pro Lys Asp Tyr Thr Gly Glu Asp Val Thr Pro Gln Asn Phe
                85                  90                  95      
Leu Ala Val Leu Arg Gly Asp Ala Glu Ala Val Lys Gly Ile Gly Ser
            100                 105                 110         
Gly Lys Val Leu Lys Ser Gly Pro Gln Asp His Val Phe Ile Tyr Phe
        115                 120                 125             
Thr Asp His Gly Ser Thr Gly Ile Leu Val Phe Pro Asn Glu Asp Leu
    130                 135                 140                 
His Val Lys Asp Leu Asn Glu Thr Ile His Tyr Met Tyr Lys His Lys
145                 150                 155                 160 
Met Tyr Arg Lys Met Val Phe Tyr Ile Glu Ala Cys Glu Ser Gly Ser
                165                 170                 175     
Met Met Asn His Leu Pro Asp Asn Ile Asn Val Tyr Ala Thr Thr Ala
            180                 185                 190         
Ala Asn Pro Arg Glu Ser Ser Tyr Ala Cys Tyr Tyr Asp Glu Lys Arg
        195                 200                 205             
Ser Thr Tyr Leu Gly Asp Trp Tyr Ser Val Asn Trp Met Glu Asp Ser
    210                 215                 220                 
Asp Val Glu Asp Leu Thr Lys Glu Thr Leu His Lys Gln Tyr His Leu
225                 230                 235                 240 
Val Lys Ser His Thr Asn Thr Ser His Val Met Gln Tyr Gly Asn Lys
                245                 250                 255     
Thr Ile Ser Thr Met Lys Val Met Gln Phe Gln Gly Met Lys Arg Lys
            260                 265                 270         
Ala Ser Ser Pro Val Pro Leu Pro Pro Val Thr His Leu Asp Leu Thr
        275                 280                 285             
Pro Ser Pro Asp Val Pro Leu Thr Ile Met Lys Arg Lys Leu Met Asn
    290                 295                 300                 
Thr Asn
305     


<210> 193
<211> 1501
<212> DNA
<213> Homo sapiens

<220> 
<223> cathepsin Z

<400> 193
ggggtcggcc gggtgctagg ccggggccga ggccgaggcc ggggcgggat ccagagcggg 60
agccggcgcg ggatctggga ctcggagcgg gatccggagc gggacccagg agccggcgcg 120
gggccatggc gaggcgcggg ccagggtggc ggccgcttct gctgctcgtg ctgctggcgg 180
gcgcggcgca gggcggcctc tacttccgcc ggggacagac ctgctaccgg cctctgcggg 240
gggacgggct ggctccgctg gggcgcagca catacccccg gcctcatgag tacctgtccc 300
cagcggatct gcccaagagc tgggactggc gcaatgtgga tggtgtcaac tatgccagca 360
tcacccggaa ccagcacatc ccccaatact gcggctcctg ctgggcccac gccagcacca 420
gcgctatggc ggatcggatc aacatcaaga ggaagggagc gtggccctcc accctcctgt 480
ccgtgcagaa cgtcatcgac tgcggtaacg ctggctcctg tgaagggggt aatgacctgt 540
ccgtgtggga ctacgcccac cagcacggca tccctgacga gacctgcaac aactaccagg 600
ccaaggacca ggagtgtgac aagtttaacc aatgtgggac atgcaatgaa ttcaaagagt 660
gccacgccat ccggaactac accctctgga gggtgggaga ctacggctcc ctctctggga 720
gggagaagat gatggcagaa atctacgcaa atggtcccat cagctgtgga ataatggcaa 780
cagaaagact ggctaactac accggaggca tctatgccga ataccaggac accacatata 840
taaaccatgt cgtttccgtg gctgggtggg gcatcagtga tgggactgag tactggattg 900
tccggaattc atggggtgaa ccatggggcg agagaggctg gctgaggatc gtgaccagca 960
cctataagga tgggaagggc gccagataca accttgccat cgaggagcac tgtacatttg 1020
gggaccccat cgtttaaggc catgtcacta gaagcgcagt ttaagaaaag gcatggtgac 1080
ccatgaccag aggggatcct atggttatgt gtgccaggct ggctggcagg aactggggtg 1140
gctatcaata ttggatggcg aggacagcgt ggtactggct gcgagtgttc ctgagagttg 1200
aaagtgggat gacttatgac acttgcacag catggctctg cctcacaatg atgcagtcag 1260
ccacctggtg aagaagtgac ctgcaacaca ggaaacgatg ggacctcagt cttcttcagc 1320
agaggacttg atattttgta tttggcaact gtgggcaata atatggcatt taagaggtga 1380
aagagttcag acttatcacc attcttatgt cactttagaa tcaagggtgg gggagggagg 1440
gagggagttg gcagtttcaa atcgcccaag tgatgaataa agtatctggc tctgcacgag 1500
a                                                                 1501

<210> 194
<211> 303
<212> PRT
<213> Homo sapiens

<220> 
<223> cathespin Z precursor

<400> 194
Met Ala Arg Arg Gly Pro Gly Trp Arg Pro Leu Leu Leu Leu Val Leu
 1               5                  10                  15      
Leu Ala Gly Ala Ala Gln Gly Gly Leu Tyr Phe Arg Arg Gly Gln Thr
            20                  25                  30          
Cys Tyr Arg Pro Leu Arg Gly Asp Gly Leu Ala Pro Leu Gly Arg Ser
        35                  40                  45              
Thr Tyr Pro Arg Pro His Glu Tyr Leu Ser Pro Ala Asp Leu Pro Lys
    50                  55                  60                  
Ser Trp Asp Trp Arg Asn Val Asp Gly Val Asn Tyr Ala Ser Ile Thr
65                  70                  75                  80  
Arg Asn Gln His Ile Pro Gln Tyr Cys Gly Ser Cys Trp Ala His Ala
                85                  90                  95      
Ser Thr Ser Ala Met Ala Asp Arg Ile Asn Ile Lys Arg Lys Gly Ala
            100                 105                 110         
Trp Pro Ser Thr Leu Leu Ser Val Gln Asn Val Ile Asp Cys Gly Asn
        115                 120                 125             
Ala Gly Ser Cys Glu Gly Gly Asn Asp Leu Ser Val Trp Asp Tyr Ala
    130                 135                 140                 
His Gln His Gly Ile Pro Asp Glu Thr Cys Asn Asn Tyr Gln Ala Lys
145                 150                 155                 160 
Asp Gln Glu Cys Asp Lys Phe Asn Gln Cys Gly Thr Cys Asn Glu Phe
                165                 170                 175     
Lys Glu Cys His Ala Ile Arg Asn Tyr Thr Leu Trp Arg Val Gly Asp

            180                 185                 190         
Tyr Gly Ser Leu Ser Gly Arg Glu Lys Met Met Ala Glu Ile Tyr Ala
        195                 200                 205             
Asn Gly Pro Ile Ser Cys Gly Ile Met Ala Thr Glu Arg Leu Ala Asn
    210                 215                 220                 
Tyr Thr Gly Gly Ile Tyr Ala Glu Tyr Gln Asp Thr Thr Tyr Ile Asn
225                 230                 235                 240 
His Val Val Ser Val Ala Gly Trp Gly Ile Ser Asp Gly Thr Glu Tyr
                245                 250                 255     
Trp Ile Val Arg Asn Ser Trp Gly Glu Pro Trp Gly Glu Arg Gly Trp
            260                 265                 270         
Leu Arg Ile Val Thr Ser Thr Tyr Lys Asp Gly Lys Gly Ala Arg Tyr
        275                 280                 285             
Asn Leu Ala Ile Glu Glu His Cys Thr Phe Gly Asp Pro Ile Val
    290                 295                 300             


<210> 195
<211> 242
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin Z mature

<400> 195
Leu Pro Lys Ser Trp Asp Trp Arg Asn Val Asp Gly Val Asn Tyr Ala
 1               5                  10                  15      
Ser Ile Thr Arg Asn Gln His Ile Pro Gln Tyr Cys Gly Ser Cys Trp
            20                  25                  30          
Ala His Ala Ser Thr Ser Ala Met Ala Asp Arg Ile Asn Ile Lys Arg
        35                  40                  45              
Lys Gly Ala Trp Pro Ser Thr Leu Leu Ser Val Gln Asn Val Ile Asp
    50                  55                  60                  
Cys Gly Asn Ala Gly Ser Cys Glu Gly Gly Asn Asp Leu Ser Val Trp
65                  70                  75                  80  
Asp Tyr Ala His Gln His Gly Ile Pro Asp Glu Thr Cys Asn Asn Tyr
                85                  90                  95      
Gln Ala Lys Asp Gln Glu Cys Asp Lys Phe Asn Gln Cys Gly Thr Cys
            100                 105                 110         
Asn Glu Phe Lys Glu Cys His Ala Ile Arg Asn Tyr Thr Leu Trp Arg
        115                 120                 125             
Val Gly Asp Tyr Gly Ser Leu Ser Gly Arg Glu Lys Met Met Ala Glu
    130                 135                 140                 
Ile Tyr Ala Asn Gly Pro Ile Ser Cys Gly Ile Met Ala Thr Glu Arg
145                 150                 155                 160 
Leu Ala Asn Tyr Thr Gly Gly Ile Tyr Ala Glu Tyr Gln Asp Thr Thr
                165                 170                 175     
Tyr Ile Asn His Val Val Ser Val Ala Gly Trp Gly Ile Ser Asp Gly
            180                 185                 190         
Thr Glu Tyr Trp Ile Val Arg Asn Ser Trp Gly Glu Pro Trp Gly Glu
        195                 200                 205             
Arg Gly Trp Leu Arg Ile Val Thr Ser Thr Tyr Lys Asp Gly Lys Gly
    210                 215                 220                 
Ala Arg Tyr Asn Leu Ala Ile Glu Glu His Cys Thr Phe Gly Asp Pro
225                 230                 235                 240 
Ile Val
        


<210> 196
<211> 2654
<212> DNA
<213> Homo sapiens

<220> 
<223> Lysosomal acid lipase

<400> 196
ttcccggtgg ctggctgctc tgattggctg aacaaatagt ccgagggtgg tgggcatccg 60
ccctcccgac aaggcagacc aggccccctg caggtcccct atccgcaccc cggcccctga 120
gagctggcac tgcgactcga gacagcggcc cggcaggaca gctccagaat gaaaatgcgg 180
ttcttggggt tggtggtctg tttggttctc tggaccctgc attctgaggg gtctggaggg 240
aaactgacag ctgtggatcc tgaaacaaac atgaatgtga gtgaaattat ctcttactgg 300
ggattcccta gtgaggaata cctagttgag acagaagatg gatatattct gtgccttaac 360
cgaattcctc atgggaggaa gaaccattct gacaaaggtc ccaaaccagt tgtcttcctg 420
caacatggct tgctggcaga ttctagtaac tgggtcacaa accttgccaa cagcagcctg 480
ggcttcattc ttgctgatgc tggttttgac gtgtggatgg gcaacagcag aggaaatacc 540
tggtctcgga aacataagac actctcagtt tctcaggatg aattctgggc tttcagttat 600
gatgagatgg caaaatatga cctaccagct tccattaact tcattctgaa taaaactggc 660
caagaacaag tgtattatgt gggtcattct caaggcacca ctataggttt tatagcattt 720
tcacagatcc ctgagctggc taaaaggatt aaaatgtttt ttgccctggg tcctgtggct 780
tccgtcgcct tctgtactag ccctatggcc aaattaggac gattaccaga tcatctcatt 840
aaggacttat ttggagacaa agaatttctt ccccagagtg cgtttttgaa gtggctgggt 900
acccacgttt gcactcatgt catactgaag gagctctgtg gaaatctctg ttttcttctg 960
tgtggattta atgagagaaa tttaaatatg tctagagtgg atgtatatac aacacattct 1020
cctgctggaa cttctgtgca aaacatgtta cactggagcc aggctgttaa attccaaaag 1080
tttcaagcct ttgactgggg aagcagtgcc aagaattatt ttcattacaa ccagagttat 1140
cctcccacat acaatgtgaa ggacatgctt gtgccgactg cagtctggag cgggggtcac 1200
gactggcttg cagatgtcta cgacgtcaat atcttactga ctcagatcac caacttggtg 1260
ttccatgaga gcattccgga atgggagcat cttgacttca tttggggcct ggatgcccct 1320
tggaggcttt ataataaaat tattaatcta atgaggaaat atcagtgaaa gctggacttg 1380
agctgtgtac caccaagtca atgattatgt catgtgaaaa tgtgtttgct tcatttctgt 1440
aaaacacttg tttttctttc ccaggtcttt tgttttttta tatccaagaa aatgataact 1500
ttgaagatgc ccagttcact ctagtttcaa ttagaaacat actagctatt ttttctttaa 1560
ttagggctgg aataggaagc cagtgtctca accatagtat tgtctcttta agtcttttaa 1620
atatcactga tgtgtaaaaa ggtcattata tccattctgt ttttaaaatt taaaatatat 1680
tgactttttg cccttcatag gacaaagtaa tatatgtgtt ggaattttaa aattgtgttg 1740
tcattggtaa atctgtcact gacttaagcg aggtataaaa gtacgcagtt ttcatgtcct 1800
tgccttaaag agctctctag tctaacggtc ttgtagttag agatctaaat gacattttat 1860
catgttttcc tgcagcaggt gcatagtcaa atccagaaat atcacagctg tgccagtaat 1920
aaggatgcta acaattaatt ttatcaaacc taactgtgac agctgtgatt tgacacgttt 1980
taattgctca ggttaaatga aatagttttc cggcgtcttc aaaaacaaat tgcactgata 2040
aaacaaaaac aaaagtatgt tttaaatgct ttgaagactg atacactcaa ccatctatat 2100
tcatgagctc tcaatttcat ggcaggccat agttctactt atctgagaag caaatccctg 2160
tggagactat accactattt tttctgagat taatgtactc ttggagcccg ctactgtcgt 2220
tattgatcac atctgtgtga agccaaagcc ccgtggttgc ccatgagaag tgtccttgtt 2280
cattttcacc caaatgaagt gtgaacgtga tgttttcgga tgcaaactca gctcagggat 2340
tcattttgtg tcttagtttt atatgcatcc ttatttttaa tacacctgct tcacgtccct 2400
atgttgggaa gtccatattt gtctgctttt cttgcagcat catttcctta caatactgtc 2460
cggtggacaa aatgacaatt gatatgtttt tctgatataa ttactttagc tgcactaaca 2520
gtacaatgct tgttaatggt taatataggc agggcgaata ctactttgta acttttaaag 2580
tcttaaactt ttcaataaaa ttgagtgaga cttataggcc caaaaaaaaa aaaaaaaaaa 2640
aaaaaaaaaa aaaa                                                   2654


<210> 197
<211> 399
<212> PRT
<213> Homo sapiens

<220> 
<223> Lysosomal acid lipase precursor

<400> 197
Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Thr
 1               5                  10                  15      
Leu His Ser Glu Gly Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu
            20                  25                  30          
Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser
        35                  40                  45              
Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn
    50                  55                  60                  
Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro
65                  70                  75                  80  
Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val
                85                  90                  95      
Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly
            100                 105                 110         
Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys
        115                 120                 125             
His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr
    130                 135                 140                 
Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu
145                 150                 155                 160 
Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly
                165                 170                 175     
Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys
            180                 185                 190         
Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe
        195                 200                 205             
Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile
    210                 215                 220                 
Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu
225                 230                 235                 240 
Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu
                245                 250                 255     
Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu
            260                 265                 270         
Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr
        275                 280                 285             
Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys
    290                 295                 300                 
Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr
305                 310                 315                 320 
Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro
                325                 330                 335     
Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp
            340                 345                 350         
Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser
        355                 360                 365             
Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro
    370                 375                 380                 
Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln
385                 390                 395                 


<210> 198
<211> 378
<212> PRT
<213> Homo sapiens

<220> 
<223> Lysosomal acid lipase maure protein

<400> 198
Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu Thr Asn Met Asn Val
 1               5                  10                  15      
Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser Glu Glu Tyr Leu Val
            20                  25                  30          
Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn Arg Ile Pro His Gly
        35                  40                  45              
Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln
    50                  55                  60                  
His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn
65                  70                  75                  80  
Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met
                85                  90                  95      
Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser
            100                 105                 110         
Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys
        115                 120                 125             
Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln
    130                 135                 140                 
Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe
145                 150                 155                 160 
Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe
                165                 170                 175     
Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met
            180                 185                 190         
Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly
        195                 200                 205             
Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr
    210                 215                 220                 
His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys
225                 230                 235                 240 
Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val
                245                 250                 255     
Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met
            260                 265                 270         
Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp
        275                 280                 285             
Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro
    290                 295                 300                 
Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser
305                 310                 315                 320 
Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu
                325                 330                 335     
Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu
            340                 345                 350         
His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn
        355                 360                 365             
Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln
    370                 375             


<210> 199
<211> 1497
<212> DNA
<213> Homo sapiens

<220> 
<223> gastric lipase

<400> 199
agatgatgcc cagatagtaa gtctttttgg taatgtaatc agtggatgag gaatctgacc 60
attgttgaag gttttgtata taagaagtca atacaacatt gaccaaaata ctaaccagcc 120
agagaaacag aatcctaact atttctgagg aaactgcagg tccaaaatgt ggctgctttt 180
aacaatggca agtttgatat ctgtactggg gactacacat ggtttgtttg gaaaattaca 240
tcctggaagc cctgaagtga ctatgaacat tagtcagatg attacttatt ggggataccc 300
aaatgaagaa tatgaagttg tgactgaaga tggttatatt cttgaagtca atagaattcc 360
ttatgggaag aaaaattcag ggaatacagg ccagagacct gttgtgtttt tgcagcatgg 420
tttgcttgca tcagccacaa actggatttc caacctgccg aacaacagcc ttgccttcat 480
tctggcagat gctggttatg atgtgtggct gggcaacagc agaggaaaca cctgggccag 540
aagaaacttg tactattcac cagattcagt tgaattctgg gctttcagct ttgatgaaat 600
ggctaaatat gaccttccag ccacaatcga cttcattgta aagaaaactg gacagaagca 660
gctacactat gttggccatt cccagggcac caccattggt tttattgcct tttccaccaa 720
tcccagcctg gctaaaagaa tcaaaacctt ctatgctcta gctcctgttg ccactgtgaa 780
gtatacaaaa agccttataa acaaacttag atttgttcct caatccctct tcaagtttat 840
atttggtgac aaaatattct acccacacaa cttctttgat caatttcttg ctactgaagt 900
gtgctcccgt gagatgctga atctcctttg cagcaatgcc ttatttataa tttgtggatt 960
tgacagtaag aactttaaca cgagtcgctt ggatgtgtat ctatcacata atccagcagg 1020
aacttctgtt caaaacatgt tccattggac ccaggctgtt aagtctggga aattccaagc 1080
ttatgactgg ggaagcccag ttcagaatag gatgcactat gatcagtccc aacctcccta 1140
ctacaatgtg acagccatga atgtaccaat tgcagtgtgg aacggtggca aggacctgtt 1200
ggctgacccc caagatgttg gccttttgct tccaaaactc cccaatctta tttaccacaa 1260
ggagattcct ttttacaatc acttggactt tatctgggca atggatgccc ctcaagaagt 1320
ttacaatgac attgtttcta tgatatcaga agataaaaag tagttctgga tttaaagaat 1380
tatccgtttg tttttccaaa atactttatt ctctcataca tagtattttc ataatgtttg 1440
acatgcagtg cttctttctg taattttgac tttagaaata tattggcatc aacaaac    1497

<210> 200
<211> 398
<212> PRT
<213> Homo sapiens

<220> 
<223> gastric lipase precursor

<400> 200
Met Trp Leu Leu Leu Thr Met Ala Ser Leu Ile Ser Val Leu Gly Thr
 1               5                  10                  15      
Thr His Gly Leu Phe Gly Lys Leu His Pro Gly Ser Pro Glu Val Thr
            20                  25                  30          
Met Asn Ile Ser Gln Met Ile Thr Tyr Trp Gly Tyr Pro Asn Glu Glu
        35                  40                  45              
Tyr Glu Val Val Thr Glu Asp Gly Tyr Ile Leu Glu Val Asn Arg Ile
    50                  55                  60                  
Pro Tyr Gly Lys Lys Asn Ser Gly Asn Thr Gly Gln Arg Pro Val Val
65                  70                  75                  80  
Phe Leu Gln His Gly Leu Leu Ala Ser Ala Thr Asn Trp Ile Ser Asn
                85                  90                  95      
Leu Pro Asn Asn Ser Leu Ala Phe Ile Leu Ala Asp Ala Gly Tyr Asp
            100                 105                 110         
Val Trp Leu Gly Asn Ser Arg Gly Asn Thr Trp Ala Arg Arg Asn Leu
        115                 120                 125             
Tyr Tyr Ser Pro Asp Ser Val Glu Phe Trp Ala Phe Ser Phe Asp Glu
    130                 135                 140                 
Met Ala Lys Tyr Asp Leu Pro Ala Thr Ile Asp Phe Ile Val Lys Lys
145                 150                 155                 160 
Thr Gly Gln Lys Gln Leu His Tyr Val Gly His Ser Gln Gly Thr Thr
                165                 170                 175     
Ile Gly Phe Ile Ala Phe Ser Thr Asn Pro Ser Leu Ala Lys Arg Ile
            180                 185                 190         
Lys Thr Phe Tyr Ala Leu Ala Pro Val Ala Thr Val Lys Tyr Thr Lys
        195                 200                 205             
Ser Leu Ile Asn Lys Leu Arg Phe Val Pro Gln Ser Leu Phe Lys Phe
    210                 215                 220                 
Ile Phe Gly Asp Lys Ile Phe Tyr Pro His Asn Phe Phe Asp Gln Phe

225                 230                 235                 240 
Leu Ala Thr Glu Val Cys Ser Arg Glu Met Leu Asn Leu Leu Cys Ser
                245                 250                 255     
Asn Ala Leu Phe Ile Ile Cys Gly Phe Asp Ser Lys Asn Phe Asn Thr
            260                 265                 270         
Ser Arg Leu Asp Val Tyr Leu Ser His Asn Pro Ala Gly Thr Ser Val
        275                 280                 285             
Gln Asn Met Phe His Trp Thr Gln Ala Val Lys Ser Gly Lys Phe Gln
    290                 295                 300                 
Ala Tyr Asp Trp Gly Ser Pro Val Gln Asn Arg Met His Tyr Asp Gln
305                 310                 315                 320 
Ser Gln Pro Pro Tyr Tyr Asn Val Thr Ala Met Asn Val Pro Ile Ala
                325                 330                 335     
Val Trp Asn Gly Gly Lys Asp Leu Leu Ala Asp Pro Gln Asp Val Gly
            340                 345                 350         
Leu Leu Leu Pro Lys Leu Pro Asn Leu Ile Tyr His Lys Glu Ile Pro
        355                 360                 365             
Phe Tyr Asn His Leu Asp Phe Ile Trp Ala Met Asp Ala Pro Gln Glu
    370                 375                 380                 
Val Tyr Asn Asp Ile Val Ser Met Ile Ser Glu Asp Lys Lys
385                 390                 395             


<210> 201
<211> 379
<212> PRT
<213> Homo sapiens

<220> 
<221> UNSURE         
<222> (0)...(0)
<223> gastric lipase mature protein

<400> 201
Leu Phe Gly Lys Leu His Pro Gly Ser Pro Glu Val Thr Met Asn Ile
 1               5                  10                  15      
Ser Gln Met Ile Thr Tyr Trp Gly Tyr Pro Asn Glu Glu Tyr Glu Val
            20                  25                  30          
Val Thr Glu Asp Gly Tyr Ile Leu Glu Val Asn Arg Ile Pro Tyr Gly
        35                  40                  45              
Lys Lys Asn Ser Gly Asn Thr Gly Gln Arg Pro Val Val Phe Leu Gln
    50                  55                  60                  
His Gly Leu Leu Ala Ser Ala Thr Asn Trp Ile Ser Asn Leu Pro Asn
65                  70                  75                  80  
Asn Ser Leu Ala Phe Ile Leu Ala Asp Ala Gly Tyr Asp Val Trp Leu
                85                  90                  95      
Gly Asn Ser Arg Gly Asn Thr Trp Ala Arg Arg Asn Leu Tyr Tyr Ser
            100                 105                 110         
Pro Asp Ser Val Glu Phe Trp Ala Phe Ser Phe Asp Glu Met Ala Lys
        115                 120                 125             
Tyr Asp Leu Pro Ala Thr Ile Asp Phe Ile Val Lys Lys Thr Gly Gln
    130                 135                 140                 
Lys Gln Leu His Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe
145                 150                 155                 160 
Ile Ala Phe Ser Thr Asn Pro Ser Leu Ala Lys Arg Ile Lys Thr Phe
                165                 170                 175     
Tyr Ala Leu Ala Pro Val Ala Thr Val Lys Tyr Thr Lys Ser Leu Ile
            180                 185                 190         
Asn Lys Leu Arg Phe Val Pro Gln Ser Leu Phe Lys Phe Ile Phe Gly
        195                 200                 205             
Asp Lys Ile Phe Tyr Pro His Asn Phe Phe Asp Gln Phe Leu Ala Thr
    210                 215                 220                 
Glu Val Cys Ser Arg Glu Met Leu Asn Leu Leu Cys Ser Asn Ala Leu
225                 230                 235                 240 
Phe Ile Ile Cys Gly Phe Asp Ser Lys Asn Phe Asn Thr Ser Arg Leu
                245                 250                 255     
Asp Val Tyr Leu Ser His Asn Pro Ala Gly Thr Ser Val Gln Asn Met
            260                 265                 270         
Phe His Trp Thr Gln Ala Val Lys Ser Gly Lys Phe Gln Ala Tyr Asp
        275                 280                 285             
Trp Gly Ser Pro Val Gln Asn Arg Met His Tyr Asp Gln Ser Gln Pro
    290                 295                 300                 
Pro Tyr Tyr Asn Val Thr Ala Met Asn Val Pro Ile Ala Val Trp Asn
305                 310                 315                 320 
Gly Gly Lys Asp Leu Leu Ala Asp Pro Gln Asp Val Gly Leu Leu Leu
                325                 330                 335     
Pro Lys Leu Pro Asn Leu Ile Tyr His Lys Glu Ile Pro Phe Tyr Asn
            340                 345                 350         
His Leu Asp Phe Ile Trp Ala Met Asp Ala Pro Gln Glu Val Tyr Asn
        355                 360                 365             
Asp Ile Val Ser Met Ile Ser Glu Asp Lys Lys
    370                 375                 


<210> 202
<211> 2764
<212> DNA
<213> Homo sapiens

<220> 
<223> Lysosomal phospholipase A2

<400> 202
aagcgcgtcg ccaccgcccc cgcctaggcg agagcccaga gagctgaacc tgcatcccgg 60
acctgcggcg accgtcgtac accatgggcc tccacctccg cccctaccgt gtggggctgc 120
tcccggatgg cctcctgttc ctcttgctgc tgctaatgct gctcgcggac ccagcgctcc 180
cggccggacg tcacccccca gtggtgctgg tccctggtga tttgggtaac caactggaag 240
ccaagctgga caagccgaca gtggtgcact acctctgctc caagaagacc gaaagctact 300
tcacaatctg gctgaacctg gaactgctgc tgcctgtcat cattgactgc tggattgaca 360
atatcaggct ggtttacaac aaaacatcca gggccaccca gtttcctgat ggtgtggatg 420
tacgtgtccc tggctttggg aagaccttct cactggagtt cctggacccc agcaaaagca 480
gcgtgggttc ctatttccac accatggtgg agagccttgt gggctggggc tacacacggg 540
gtgaggatgt ccgaggggct ccctatgact ggcgccgagc cccaaatgaa aacgggccct 600
acttcctggc cctccgcgag atgatcgagg agatgtacca gctgtatggg ggccccgtgg 660
tgctggttgc ccacagtatg ggcaacatgt acacgctcta ctttctgcag cggcagccgc 720
aggcctggaa ggacaagtat atccgggcct tcgtgtcact gggtgcgccc tgggggggcg 780
tggccaagac cctgcgcgtc ctggcttcag gagacaacaa ccggatccca gtcatcgggc 840
ccctgaagat ccgggagcag cagcggtcag ctgtctccac cagctggctg ctgccctaca 900
actacacatg gtcacctgag aaggtgttcg tgcagacacc cacaatcaac tacacactgc 960
gggactaccg caagttcttc caggacatcg gctttgaaga tggctggctc atgcggcagg 1020
acacagaagg gctggtggaa gccacgatgc cacctggcgt gcagctgcac tgcctctatg 1080
gtactggcgt ccccacacca gactccttct actatgagag cttccctgac cgtgacccta 1140
aaatctgctt tggtgacggc gatggtactg tgaacttgaa gagtgccctg cagtgccagg 1200
cctggcagag ccgccaggag caccaagtgt tgctgcagga gctgccaggc agcgagcaca 1260
tcgagatgct ggccaacgcc accaccctgg cctatctgaa acgtgtgctc cttgggccct 1320
gactcctgtg ccacaggact cctgtggctc ggccgtggac ctgctgttgg cctctggggc 1380
tgtcatggcc cacgcgtttt gcaaagtttg tgactcacca ttcaaggccc cgagtcttgg 1440
actgtgaagc atctgccatg gggaagtgct gtttgttatc ctttctctgt ggcagtgaag 1500
aaggaagaaa tgagagtcta gactcaaggg acactggatg gcaagaatgc tgctgatggt 1560
ggaactgctg tgaccttagg actggctcca cagggtggac tggctgggcc ctggtcccag 1620
tccctgcctg gggccatgtg tcccccctat tcctgtgggc ttttcatact tgcctactgg 1680
gccctggccc cgcagccttc ctatgaggga tgttactggg ctgtggtcct gtacccagag 1740
gtcccaggga tcggctcctg gcccctcggg tgacccttcc cacacaccag ccacagatag 1800
gcctgccact ggtcatgggt agctagagct gctggcttcc ctgtggctta gctggtggcc 1860
agcctgactg gcttcctggg cgagcctagt agctcctgca ggcaggggca gtttgttgcg 1920
ttcttcgtgg ttcccaggcc ctgggacatc tcactccact cctacctccc ttaccaccag 1980
gagcattcaa gctctggatt gggcagcaga tgtgccccca gtcccgcagg ctgtgttcca 2040
ggggccctga tttcctcgga tgtgctattg gccccaggac tgaagctgcc tcccttcacc 2100
ctgggactgt ggttccaagg atgagagcag gggttggagc catggccttc tgggaaccta 2160
tggagaaagg gaatccaagg aagcagccaa ggctgctcgc agcttccctg agctgcacct 2220
cttgctaacc ccaccatcac actgccaccc tgccctaggg tctcactagt accaagtggg 2280
tcagcacagg gctgaggatg gggctcctat ccaccctggc cagcacccag cttagtgctg 2340
ggactagccc agaaacttga atgggaccct gagagagcca ggggtcccct gaggcccccc 2400
taggggcttt ctgtctgccc cagggtgctc catggatctc cctgtggcag caggcatgga 2460
gagtcagggc tgccttcatg gcagtaggct ctaagtgggt gactggccac aggccgagaa 2520
aagggtacag cctctaggtg gggttcccaa agacgccttc acgctggact gagctgctct 2580
cccacagggt ttctgtgcag ctggattttc tctgttgcat acatgcctgg catctgtctc 2640
cccttgttcc tgagtggccc cacatggggc tctgagcagg ctgtatctgg attctggcaa 2700
taaaagtact ctggatgctg taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2760
aaaa                                                              2764

<210> 203
<211> 412
<212> PRT
<213> Homo sapiens

<220> 
<223> Lysosomal phospholipase A2 precursor

<400> 203
Met Gly Leu His Leu Arg Pro Tyr Arg Val Gly Leu Leu Pro Asp Gly
 1               5                  10                  15      
Leu Leu Phe Leu Leu Leu Leu Leu Met Leu Leu Ala Asp Pro Ala Leu
            20                  25                  30          
Pro Ala Gly Arg His Pro Pro Val Val Leu Val Pro Gly Asp Leu Gly
        35                  40                  45              
Asn Gln Leu Glu Ala Lys Leu Asp Lys Pro Thr Val Val His Tyr Leu
    50                  55                  60                  
Cys Ser Lys Lys Thr Glu Ser Tyr Phe Thr Ile Trp Leu Asn Leu Glu
65                  70                  75                  80  
Leu Leu Leu Pro Val Ile Ile Asp Cys Trp Ile Asp Asn Ile Arg Leu
                85                  90                  95      
Val Tyr Asn Lys Thr Ser Arg Ala Thr Gln Phe Pro Asp Gly Val Asp
            100                 105                 110         
Val Arg Val Pro Gly Phe Gly Lys Thr Phe Ser Leu Glu Phe Leu Asp
        115                 120                 125             
Pro Ser Lys Ser Ser Val Gly Ser Tyr Phe His Thr Met Val Glu Ser
    130                 135                 140                 
Leu Val Gly Trp Gly Tyr Thr Arg Gly Glu Asp Val Arg Gly Ala Pro
145                 150                 155                 160 
Tyr Asp Trp Arg Arg Ala Pro Asn Glu Asn Gly Pro Tyr Phe Leu Ala
                165                 170                 175     
Leu Arg Glu Met Ile Glu Glu Met Tyr Gln Leu Tyr Gly Gly Pro Val
            180                 185                 190         
Val Leu Val Ala His Ser Met Gly Asn Met Tyr Thr Leu Tyr Phe Leu
        195                 200                 205             
Gln Arg Gln Pro Gln Ala Trp Lys Asp Lys Tyr Ile Arg Ala Phe Val
    210                 215                 220                 
Ser Leu Gly Ala Pro Trp Gly Gly Val Ala Lys Thr Leu Arg Val Leu
225                 230                 235                 240 
Ala Ser Gly Asp Asn Asn Arg Ile Pro Val Ile Gly Pro Leu Lys Ile
                245                 250                 255     
Arg Glu Gln Gln Arg Ser Ala Val Ser Thr Ser Trp Leu Leu Pro Tyr
            260                 265                 270         
Asn Tyr Thr Trp Ser Pro Glu Lys Val Phe Val Gln Thr Pro Thr Ile
        275                 280                 285             
Asn Tyr Thr Leu Arg Asp Tyr Arg Lys Phe Phe Gln Asp Ile Gly Phe
    290                 295                 300                 
Glu Asp Gly Trp Leu Met Arg Gln Asp Thr Glu Gly Leu Val Glu Ala
305                 310                 315                 320 
Thr Met Pro Pro Gly Val Gln Leu His Cys Leu Tyr Gly Thr Gly Val
                325                 330                 335     
Pro Thr Pro Asp Ser Phe Tyr Tyr Glu Ser Phe Pro Asp Arg Asp Pro
            340                 345                 350         
Lys Ile Cys Phe Gly Asp Gly Asp Gly Thr Val Asn Leu Lys Ser Ala
        355                 360                 365             
Leu Gln Cys Gln Ala Trp Gln Ser Arg Gln Glu His Gln Val Leu Leu
    370                 375                 380                 
Gln Glu Leu Pro Gly Ser Glu His Ile Glu Met Leu Ala Asn Ala Thr
385                 390                 395                 400 
Thr Leu Ala Tyr Leu Lys Arg Val Leu Leu Gly Pro
                405                 410         


<210> 204
<211> 379
<212> PRT
<213> Homo sapiens

<220> 
<223> Lysosomal phospholipase A2 mature protein

<400> 204
Ala Gly Arg His Pro Pro Val Val Leu Val Pro Gly Asp Leu Gly Asn
 1               5                  10                  15      
Gln Leu Glu Ala Lys Leu Asp Lys Pro Thr Val Val His Tyr Leu Cys
            20                  25                  30          
Ser Lys Lys Thr Glu Ser Tyr Phe Thr Ile Trp Leu Asn Leu Glu Leu
        35                  40                  45              
Leu Leu Pro Val Ile Ile Asp Cys Trp Ile Asp Asn Ile Arg Leu Val
    50                  55                  60                  
Tyr Asn Lys Thr Ser Arg Ala Thr Gln Phe Pro Asp Gly Val Asp Val
65                  70                  75                  80  
Arg Val Pro Gly Phe Gly Lys Thr Phe Ser Leu Glu Phe Leu Asp Pro
                85                  90                  95      
Ser Lys Ser Ser Val Gly Ser Tyr Phe His Thr Met Val Glu Ser Leu
            100                 105                 110         
Val Gly Trp Gly Tyr Thr Arg Gly Glu Asp Val Arg Gly Ala Pro Tyr
        115                 120                 125             
Asp Trp Arg Arg Ala Pro Asn Glu Asn Gly Pro Tyr Phe Leu Ala Leu
    130                 135                 140                 
Arg Glu Met Ile Glu Glu Met Tyr Gln Leu Tyr Gly Gly Pro Val Val
145                 150                 155                 160 
Leu Val Ala His Ser Met Gly Asn Met Tyr Thr Leu Tyr Phe Leu Gln
                165                 170                 175     
Arg Gln Pro Gln Ala Trp Lys Asp Lys Tyr Ile Arg Ala Phe Val Ser
            180                 185                 190         
Leu Gly Ala Pro Trp Gly Gly Val Ala Lys Thr Leu Arg Val Leu Ala
        195                 200                 205             
Ser Gly Asp Asn Asn Arg Ile Pro Val Ile Gly Pro Leu Lys Ile Arg
    210                 215                 220                 
Glu Gln Gln Arg Ser Ala Val Ser Thr Ser Trp Leu Leu Pro Tyr Asn
225                 230                 235                 240 
Tyr Thr Trp Ser Pro Glu Lys Val Phe Val Gln Thr Pro Thr Ile Asn
                245                 250                 255     

Tyr Thr Leu Arg Asp Tyr Arg Lys Phe Phe Gln Asp Ile Gly Phe Glu
            260                 265                 270         
Asp Gly Trp Leu Met Arg Gln Asp Thr Glu Gly Leu Val Glu Ala Thr
        275                 280                 285             
Met Pro Pro Gly Val Gln Leu His Cys Leu Tyr Gly Thr Gly Val Pro
    290                 295                 300                 
Thr Pro Asp Ser Phe Tyr Tyr Glu Ser Phe Pro Asp Arg Asp Pro Lys
305                 310                 315                 320 
Ile Cys Phe Gly Asp Gly Asp Gly Thr Val Asn Leu Lys Ser Ala Leu
                325                 330                 335     
Gln Cys Gln Ala Trp Gln Ser Arg Gln Glu His Gln Val Leu Leu Gln
            340                 345                 350         
Glu Leu Pro Gly Ser Glu His Ile Glu Met Leu Ala Asn Ala Thr Thr
        355                 360                 365             
Leu Ala Tyr Leu Lys Arg Val Leu Leu Gly Pro
    370                 375                 


<210> 205
<211> 2428
<212> DNA
<213> Homo sapiens

<220> 
<223> Bile salt-activated lipase

<400> 205
accttctgta tcagttaagt gtcaagatgg aaggaacagc agtctcaaga taatgcaaag 60
agtttattca tccagaggct gatgctcacc atggggcgcc tgcaactggt tgtgttgggc 120
ctcacctgct gctgggcagt ggcgagtgcc gcgaagctgg gcgccgtgta cacagaaggt 180
gggttcgtgg aaggcgtcaa taagaagctc ggcctcctgg gtgactctgt ggacatcttc 240
aagggcatcc ccttcgcagc tcccaccaag gccctggaaa atcctcagcc acatcctggc 300
tggcaaggga ccctgaaggc caagaacttc aagaagagat gcctgcaggc caccatcacc 360
caggacagca cctacgggga tgaagactgc ctgtacctca acatttgggt gccccagggc 420
aggaagcaag tctcccggga cctgcccgtt atgatctgga tctatggagg cgccttcctc 480
atggggtccg gccatggggc caacttcctc aacaactacc tgtatgacgg cgaggagatc 540
gccacacgcg gaaacgtcat cgtggtcacc ttcaactacc gtgtcggccc ccttgggttc 600
ctcagcactg gggacgccaa tctgccaggt aactatggcc ttcgggatca gcacatggcc 660
attgcttggg tgaagaggaa tatcgcggcc ttcggggggg accccaacaa catcacgctc 720
ttcggggagt ctgctggagg tgccagcgtc tctctgcaga ccctctcccc ctacaacaag 780
ggcctcatcc ggcgagccat cagccagagc ggcgtggccc tgagtccctg ggtcatccag 840
aaaaacccac tcttctgggc caaaaaggtg gctgagaagg tgggttgccc tgtgggtgat 900
gccgccagga tggcccagtg tctgaaggtt actgatcccc gagccctgac gctggcctat 960
aaggtgccgc tggcaggcct ggagtacccc atgctgcact atgtgggctt cgtccctgtc 1020
attgatggag acttcatccc cgctgacccg atcaacctgt acgccaacgc cgccgacatc 1080
gactatatag caggcaccaa caacatggac ggccacatct tcgccagcat cgacatgcct 1140
gccatcaaca agggcaacaa gaaagtcacg gaggaggact tctacaagct ggtcagtgag 1200
ttcacaatca ccaaggggct cagaggcgcc aagacgacct ttgatgtcta caccgagtcc 1260
tgggcccagg acccatccca ggagaataag aagaagactg tggtggactt tgagaccgat 1320
gtcctcttcc tggtgcccac cgagattgcc ctagcccagc acagagccaa tgccaagagt 1380
gccaagacct acgcctacct gttttcccat ccctctcgga tgcccgtcta ccccaaatgg 1440
gtgggggccg accatgcaga tgacattcag tacgttttcg ggaagccctt cgccaccccc 1500
acgggctacc ggccccaaga caggacagtc tctaaggcca tgatcgccta ctggaccaac 1560
tttgccaaaa caggggaccc caacatgggc gactcggctg tgcccacaca ctgggaaccc 1620
tacactacgg aaaacagcgg ctacctggag atcaccaaga agatgggcag cagctccatg 1680
aagcggagcc tgagaaccaa cttcctgcgc tactggaccc tcacctatct ggcgctgccc 1740
acagtgaccg accaggaggc cacccctgtg ccccccacag gggactccga ggccactccc 1800
gtgcccccca cgggtgactc cgagaccgcc cccgtgccgc ccacgggtga ctccggggcc 1860
ccccccgtgc cgcccacggg tgactccggg gccccccccg tgccgcccac gggtgactcc 1920
ggggcccccc ccgtgccgcc cacgggtgac tccggggccc cccccgtgcc gcccacgggt 1980
gactccgggg ccccccccgt gccgcccacg ggtgactccg gggccccccc cgtgccgccc 2040
acgggtgact ccggcgcccc ccccgtgccg cccacgggtg acgccgggcc cccccccgtg 2100
ccgcccacgg gtgactccgg cgcccccccc gtgccgccca cgggtgactc cggggccccc 2160
cccgtgaccc ccacgggtga ctccgagacc gcccccgtgc cgcccacggg tgactccggg 2220
gccccccctg tgccccccac gggtgactct gaggctgccc ctgtgccccc cacagatgac 2280
tccaaggaag ctcagatgcc tgcagtcatt aggttttagc gtcccatgag ccttggtatc 2340
aagaggccac aagagtggga ccccaggggc tcccctccca tcttgagctc ttcctgaata 2400
aagcctcata cccctaaaaa aaaaaaaa                                    2428

<210> 206
<211> 745
<212> PRT
<213> Homo sapiens

<220> 
<223> bile-salt-stimulated lipase precursor

<400> 206
Met Leu Thr Met Gly Arg Leu Gln Leu Val Val Leu Gly Leu Thr Cys
 1               5                  10                  15      
Cys Trp Ala Val Ala Ser Ala Ala Lys Leu Gly Ala Val Tyr Thr Glu
            20                  25                  30          
Gly Gly Phe Val Glu Gly Val Asn Lys Lys Leu Gly Leu Leu Gly Asp
        35                  40                  45              
Ser Val Asp Ile Phe Lys Gly Ile Pro Phe Ala Ala Pro Thr Lys Ala
    50                  55                  60                  
Leu Glu Asn Pro Gln Pro His Pro Gly Trp Gln Gly Thr Leu Lys Ala
65                  70                  75                  80  
Lys Asn Phe Lys Lys Arg Cys Leu Gln Ala Thr Ile Thr Gln Asp Ser
                85                  90                  95      
Thr Tyr Gly Asp Glu Asp Cys Leu Tyr Leu Asn Ile Trp Val Pro Gln
            100                 105                 110         
Gly Arg Lys Gln Val Ser Arg Asp Leu Pro Val Met Ile Trp Ile Tyr
        115                 120                 125             
Gly Gly Ala Phe Leu Met Gly Ser Gly His Gly Ala Asn Phe Leu Asn
    130                 135                 140                 
Asn Tyr Leu Tyr Asp Gly Glu Glu Ile Ala Thr Arg Gly Asn Val Ile
145                 150                 155                 160 
Val Val Thr Phe Asn Tyr Arg Val Gly Pro Leu Gly Phe Leu Ser Thr
                165                 170                 175     
Gly Asp Ala Asn Leu Pro Gly Asn Tyr Gly Leu Arg Asp Gln His Met
            180                 185                 190         
Ala Ile Ala Trp Val Lys Arg Asn Ile Ala Ala Phe Gly Gly Asp Pro
        195                 200                 205             
Asn Asn Ile Thr Leu Phe Gly Glu Ser Ala Gly Gly Ala Ser Val Ser
    210                 215                 220                 
Leu Gln Thr Leu Ser Pro Tyr Asn Lys Gly Leu Ile Arg Arg Ala Ile
225                 230                 235                 240 
Ser Gln Ser Gly Val Ala Leu Ser Pro Trp Val Ile Gln Lys Asn Pro
                245                 250                 255     
Leu Phe Trp Ala Lys Lys Val Ala Glu Lys Val Gly Cys Pro Val Gly
            260                 265                 270         
Asp Ala Ala Arg Met Ala Gln Cys Leu Lys Val Thr Asp Pro Arg Ala
        275                 280                 285             
Leu Thr Leu Ala Tyr Lys Val Pro Leu Ala Gly Leu Glu Tyr Pro Met
    290                 295                 300                 
Leu His Tyr Val Gly Phe Val Pro Val Ile Asp Gly Asp Phe Ile Pro
305                 310                 315                 320 
Ala Asp Pro Ile Asn Leu Tyr Ala Asn Ala Ala Asp Ile Asp Tyr Ile
                325                 330                 335     
Ala Gly Thr Asn Asn Met Asp Gly His Ile Phe Ala Ser Ile Asp Met
            340                 345                 350         
Pro Ala Ile Asn Lys Gly Asn Lys Lys Val Thr Glu Glu Asp Phe Tyr
        355                 360                 365             
Lys Leu Val Ser Glu Phe Thr Ile Thr Lys Gly Leu Arg Gly Ala Lys
    370                 375                 380                 
Thr Thr Phe Asp Val Tyr Thr Glu Ser Trp Ala Gln Asp Pro Ser Gln
385                 390                 395                 400 
Glu Asn Lys Lys Lys Thr Val Val Asp Phe Glu Thr Asp Val Leu Phe
                405                 410                 415     
Leu Val Pro Thr Glu Ile Ala Leu Ala Gln His Arg Ala Asn Ala Lys
            420                 425                 430         
Ser Ala Lys Thr Tyr Ala Tyr Leu Phe Ser His Pro Ser Arg Met Pro
        435                 440                 445             
Val Tyr Pro Lys Trp Val Gly Ala Asp His Ala Asp Asp Ile Gln Tyr
    450                 455                 460                 
Val Phe Gly Lys Pro Phe Ala Thr Pro Thr Gly Tyr Arg Pro Gln Asp
465                 470                 475                 480 
Arg Thr Val Ser Lys Ala Met Ile Ala Tyr Trp Thr Asn Phe Ala Lys
                485                 490                 495     
Thr Gly Asp Pro Asn Met Gly Asp Ser Ala Val Pro Thr His Trp Glu
            500                 505                 510         
Pro Tyr Thr Thr Glu Asn Ser Gly Tyr Leu Glu Ile Thr Lys Lys Met
        515                 520                 525             
Gly Ser Ser Ser Met Lys Arg Ser Leu Arg Thr Asn Phe Leu Arg Tyr
    530                 535                 540                 
Trp Thr Leu Thr Tyr Leu Ala Leu Pro Thr Val Thr Asp Gln Glu Ala
545                 550                 555                 560 
Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Thr Pro Val Pro Pro
                565                 570                 575     
Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp Ser Gly
            580                 585                 590         
Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro
        595                 600                 605             
Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser
    610                 615                 620                 
Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val
625                 630                 635                 640 
Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp
                645                 650                 655     
Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ala Gly Pro Pro Pro
            660                 665                 670         
Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly
        675                 680                 685             
Asp Ser Gly Ala Pro Pro Val Thr Pro Thr Gly Asp Ser Glu Thr Ala
    690                 695                 700                 
Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr
705                 710                 715                 720 
Gly Asp Ser Glu Ala Ala Pro Val Pro Pro Thr Asp Asp Ser Lys Glu
                725                 730                 735     
Ala Gln Met Pro Ala Val Ile Arg Phe
            740                 745 


<210> 207
<211> 722
<212> PRT
<213> Homo sapiens

<220> 
<223> Bile salt-activated lipase mature protein

<400> 207
Ala Lys Leu Gly Ala Val Tyr Thr Glu Gly Gly Phe Val Glu Gly Val
 1               5                  10                  15      
Asn Lys Lys Leu Gly Leu Leu Gly Asp Ser Val Asp Ile Phe Lys Gly
            20                  25                  30          
Ile Pro Phe Ala Ala Pro Thr Lys Ala Leu Glu Asn Pro Gln Pro His
        35                  40                  45              
Pro Gly Trp Gln Gly Thr Leu Lys Ala Lys Asn Phe Lys Lys Arg Cys
    50                  55                  60                  
Leu Gln Ala Thr Ile Thr Gln Asp Ser Thr Tyr Gly Asp Glu Asp Cys
65                  70                  75                  80  
Leu Tyr Leu Asn Ile Trp Val Pro Gln Gly Arg Lys Gln Val Ser Arg
                85                  90                  95      
Asp Leu Pro Val Met Ile Trp Ile Tyr Gly Gly Ala Phe Leu Met Gly
            100                 105                 110         
Ser Gly His Gly Ala Asn Phe Leu Asn Asn Tyr Leu Tyr Asp Gly Glu
        115                 120                 125             
Glu Ile Ala Thr Arg Gly Asn Val Ile Val Val Thr Phe Asn Tyr Arg
    130                 135                 140                 
Val Gly Pro Leu Gly Phe Leu Ser Thr Gly Asp Ala Asn Leu Pro Gly
145                 150                 155                 160 
Asn Tyr Gly Leu Arg Asp Gln His Met Ala Ile Ala Trp Val Lys Arg
                165                 170                 175     
Asn Ile Ala Ala Phe Gly Gly Asp Pro Asn Asn Ile Thr Leu Phe Gly
            180                 185                 190         
Glu Ser Ala Gly Gly Ala Ser Val Ser Leu Gln Thr Leu Ser Pro Tyr
        195                 200                 205             
Asn Lys Gly Leu Ile Arg Arg Ala Ile Ser Gln Ser Gly Val Ala Leu
    210                 215                 220                 
Ser Pro Trp Val Ile Gln Lys Asn Pro Leu Phe Trp Ala Lys Lys Val
225                 230                 235                 240 
Ala Glu Lys Val Gly Cys Pro Val Gly Asp Ala Ala Arg Met Ala Gln
                245                 250                 255     
Cys Leu Lys Val Thr Asp Pro Arg Ala Leu Thr Leu Ala Tyr Lys Val
            260                 265                 270         
Pro Leu Ala Gly Leu Glu Tyr Pro Met Leu His Tyr Val Gly Phe Val
        275                 280                 285             
Pro Val Ile Asp Gly Asp Phe Ile Pro Ala Asp Pro Ile Asn Leu Tyr
    290                 295                 300                 
Ala Asn Ala Ala Asp Ile Asp Tyr Ile Ala Gly Thr Asn Asn Met Asp
305                 310                 315                 320 
Gly His Ile Phe Ala Ser Ile Asp Met Pro Ala Ile Asn Lys Gly Asn
                325                 330                 335     
Lys Lys Val Thr Glu Glu Asp Phe Tyr Lys Leu Val Ser Glu Phe Thr
            340                 345                 350         
Ile Thr Lys Gly Leu Arg Gly Ala Lys Thr Thr Phe Asp Val Tyr Thr
        355                 360                 365             
Glu Ser Trp Ala Gln Asp Pro Ser Gln Glu Asn Lys Lys Lys Thr Val
    370                 375                 380                 
Val Asp Phe Glu Thr Asp Val Leu Phe Leu Val Pro Thr Glu Ile Ala
385                 390                 395                 400 
Leu Ala Gln His Arg Ala Asn Ala Lys Ser Ala Lys Thr Tyr Ala Tyr
                405                 410                 415     
Leu Phe Ser His Pro Ser Arg Met Pro Val Tyr Pro Lys Trp Val Gly
            420                 425                 430         
Ala Asp His Ala Asp Asp Ile Gln Tyr Val Phe Gly Lys Pro Phe Ala
        435                 440                 445             
Thr Pro Thr Gly Tyr Arg Pro Gln Asp Arg Thr Val Ser Lys Ala Met
    450                 455                 460                 
Ile Ala Tyr Trp Thr Asn Phe Ala Lys Thr Gly Asp Pro Asn Met Gly
465                 470                 475                 480 
Asp Ser Ala Val Pro Thr His Trp Glu Pro Tyr Thr Thr Glu Asn Ser
                485                 490                 495     
Gly Tyr Leu Glu Ile Thr Lys Lys Met Gly Ser Ser Ser Met Lys Arg
            500                 505                 510         
Ser Leu Arg Thr Asn Phe Leu Arg Tyr Trp Thr Leu Thr Tyr Leu Ala
        515                 520                 525             
Leu Pro Thr Val Thr Asp Gln Glu Ala Thr Pro Val Pro Pro Thr Gly
    530                 535                 540                 
Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala
545                 550                 555                 560 
Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr
                565                 570                 575     
Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala
            580                 585                 590         
Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro
        595                 600                 605             
Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly
    610                 615                 620                 
Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro
625                 630                 635                 640 
Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser
                645                 650                 655     
Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val
            660                 665                 670         
Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp
        675                 680                 685             
Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro
    690                 695                 700                 
Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Gln Met Pro Ala Val Ile
705                 710                 715                 720 
Arg Phe
        


<210> 208
<211> 334
<212> PRT
<213> Bos taurus

<220> 
<223> cathepsin L precursor

<400> 208
Met Asn Pro Ser Phe Phe Leu Thr Val Leu Cys Leu Gly Val Ala Ser
 1               5                  10                  15      
Ala Ala Pro Lys Leu Asp Pro Asn Leu Asp Ala His Trp His Gln Trp
            20                  25                  30          
Lys Ala Thr His Arg Arg Leu Tyr Gly Met Asn Glu Glu Glu Trp Arg
        35                  40                  45              
Arg Ala Val Trp Glu Lys Asn Lys Lys Ile Ile Asp Leu His Asn Gln
    50                  55                  60                  
Glu Tyr Ser Glu Gly Lys His Gly Phe Arg Met Ala Met Asn Ala Phe
65                  70                  75                  80  
Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln

                85                  90                  95      
Asn Gln Lys His Lys Lys Gly Lys Leu Phe His Glu Pro Leu Leu Val
            100                 105                 110         
Asp Val Pro Lys Ser Val Asp Trp Thr Lys Lys Gly Tyr Val Thr Pro
        115                 120                 125             
Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr
    130                 135                 140                 
Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser
145                 150                 155                 160 
Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Arg Ala Gln Gly Asn Gln
                165                 170                 175     
Gly Cys Asn Gly Gly Leu Met Asp Asn Ala Phe Gln Tyr Ile Lys Asp
            180                 185                 190         
Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Leu Ala Thr Asp
        195                 200                 205             
Thr Asn Ser Cys Asn Tyr Lys Pro Glu Cys Ser Ala Ala Asn Asp Thr
    210                 215                 220                 
Gly Phe Val Asp Ile Pro Gln Arg Glu Lys Ala Leu Met Lys Ala Val
225                 230                 235                 240 
Ala Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Thr Ser
                245                 250                 255     
Phe Gln Phe Tyr Lys Ser Gly Ile Tyr Tyr Asp Pro Asp Cys Ser Ser
            260                 265                 270         
Lys Asp Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly
        275                 280                 285             
Thr Asp Ser Asn Asn Asn Lys Phe Trp Ile Val Lys Asn Ser Trp Gly
    290                 295                 300                 
Pro Glu Trp Gly Trp Asn Gly Tyr Val Lys Met Ala Lys Asp Gln Asn
305                 310                 315                 320 
Asn His Cys Gly Ile Ala Thr Ala Ala Ser Tyr Pro Thr Val
                325                 330                 


<210> 209
<211> 217
<212> PRT
<213> Bos taurus

<220> 
<223> cathepsin L mature

<400> 209
Val Asp Trp Thr Lys Lys Gly Tyr Val Thr Pro Val Lys Asn Gln Gly
 1               5                  10                  15      
Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr Gly Ala Leu Glu Gly
            20                  25                  30          
Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser Leu Ser Glu Gln Asn
        35                  40                  45              
Leu Val Asp Cys Ser Arg Ala Gln Gly Asn Gln Gly Cys Asn Gly Gly
    50                  55                  60                  
Leu Met Asp Asn Ala Phe Gln Tyr Ile Lys Asp Asn Gly Gly Leu Asp
65                  70                  75                  80  
Ser Glu Glu Ser Tyr Pro Tyr Leu Ala Thr Asp Thr Asn Ser Cys Asn
                85                  90                  95      
Tyr Lys Pro Glu Cys Ser Ala Ala Asn Asp Thr Gly Phe Val Asp Ile
            100                 105                 110         
Pro Gln Arg Glu Lys Ala Leu Met Lys Ala Val Ala Thr Val Gly Pro
        115                 120                 125             
Ile Ser Val Ala Ile Asp Ala Gly His Thr Ser Phe Gln Phe Tyr Lys
    130                 135                 140                 
Ser Gly Ile Tyr Tyr Asp Pro Asp Cys Ser Ser Lys Asp Leu Asp His
145                 150                 155                 160 
Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly Thr Asp Ser Asn Asn
                165                 170                 175     
Asn Lys Phe Trp Ile Val Lys Asn Ser Trp Gly Pro Glu Trp Gly Trp
            180                 185                 190         
Asn Gly Tyr Val Lys Met Ala Lys Asp Gln Asn Asn His Cys Gly Ile
        195                 200                 205             
Ala Thr Ala Ala Ser Tyr Pro Thr Val
    210                 215         


<210> 210
<211> 333
<212> PRT
<213> Canis familiaris

<220> 
<223> cathepsin L precursor

<400> 210
Met Asn Pro Ser Leu Phe Leu Thr Ala Leu Cys Leu Gly Ile Ala Ser
 1               5                  10                  15      
Ala Ala Pro Lys Phe Asp Gln Ser Leu Asn Ala Gln Trp Tyr Gln Trp
            20                  25                  30          
Lys Ala Thr His Arg Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg
        35                  40                  45              
Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Arg
    50                  55                  60                  
Glu Tyr Ser Gln Gly Lys His Gly Phe Thr Met Ala Met Asn Ala Phe
65                  70                  75                  80  
Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln
                85                  90                  95      
Asn Gln Lys His Lys Lys Gly Lys Met Phe Gln Glu Pro Leu Phe Ala
            100                 105                 110         
Glu Ile Pro Lys Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro
        115                 120                 125             
Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr
    130                 135                 140                 
Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser
145                 150                 155                 160 
Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Arg Ala Gln Gly Asn Glu
                165                 170                 175     
Gly Cys Asn Gly Gly Leu Met Asp Asn Ala Phe Arg Tyr Val Lys Asp
            180                 185                 190         
Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Leu Gly Arg Asp
        195                 200                 205             
Thr Glu Thr Cys Asn Tyr Lys Pro Glu Cys Ser Ala Ala Asn Asp Thr
    210                 215                 220                 
Gly Phe Val Asp Leu Pro Gln Arg Glu Lys Ala Leu Met Lys Ala Val
225                 230                 235                 240 
Ala Thr Leu Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Gln Ser
                245                 250                 255     
Phe Gln Phe Tyr Lys Ser Gly Ile Tyr Phe Asp Pro Asp Cys Ser Ser
            260                 265                 270         
Lys Asp Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly
        275                 280                 285             
Thr Asp Ser Asn Asn Lys Phe Trp Ile Val Lys Asn Ser Trp Gly Pro
    290                 295                 300                 
Glu Trp Gly Trp Asn Gly Tyr Val Lys Met Ala Lys Asp Gln Asn Asn
305                 310                 315                 320 
His Cys Gly Ile Ala Thr Ala Ala Ser Tyr Pro Thr Val
                325                 330             


<210> 211
<211> 216
<212> PRT
<213> Canis familiaris

<220> 
<223> cathepsin L mature

<400> 211
Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro Val Lys Asn Gln Gly

 1               5                  10                  15      
Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr Gly Ala Leu Glu Gly
            20                  25                  30          
Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser Leu Ser Glu Gln Asn
        35                  40                  45              
Leu Val Asp Cys Ser Arg Ala Gln Gly Asn Glu Gly Cys Asn Gly Gly
    50                  55                  60                  
Leu Met Asp Asn Ala Phe Arg Tyr Val Lys Asp Asn Gly Gly Leu Asp
65                  70                  75                  80  
Ser Glu Glu Ser Tyr Pro Tyr Leu Gly Arg Asp Thr Glu Thr Cys Asn
                85                  90                  95      
Tyr Lys Pro Glu Cys Ser Ala Ala Asn Asp Thr Gly Phe Val Asp Leu
            100                 105                 110         
Pro Gln Arg Glu Lys Ala Leu Met Lys Ala Val Ala Thr Leu Gly Pro
        115                 120                 125             
Ile Ser Val Ala Ile Asp Ala Gly His Gln Ser Phe Gln Phe Tyr Lys
    130                 135                 140                 
Ser Gly Ile Tyr Phe Asp Pro Asp Cys Ser Ser Lys Asp Leu Asp His
145                 150                 155                 160 
Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly Thr Asp Ser Asn Asn
                165                 170                 175     
Lys Phe Trp Ile Val Lys Asn Ser Trp Gly Pro Glu Trp Gly Trp Asn
            180                 185                 190         
Gly Tyr Val Lys Met Ala Lys Asp Gln Asn Asn His Cys Gly Ile Ala
        195                 200                 205             
Thr Ala Ala Ser Tyr Pro Thr Val
    210                 215     


<210> 212
<211> 333
<212> PRT
<213> Cercopithecus aethiops

<220> 
<223> cathepsin L precursor

<400> 212
Met Asn Pro Thr Phe Ile Leu Ala Ala Leu Cys Leu Gly Ile Ala Ser
 1               5                  10                  15      
Ala Thr Leu Thr Phe Asn His Ser Leu Glu Ala Gln Trp Thr Lys Trp
            20                  25                  30          
Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg
        35                  40                  45              
Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln
    50                  55                  60                  
Glu Tyr Ser Gln Gly Lys His Ser Phe Thr Met Ala Met Asn Thr Phe
65                  70                  75                  80  
Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln
                85                  90                  95      
Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr
            100                 105                 110         
Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro
        115                 120                 125             
Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr
    130                 135                 140                 
Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser
145                 150                 155                 160 
Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu
                165                 170                 175     
Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Ala Asp
            180                 185                 190         
Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu
        195                 200                 205             
Glu Ser Cys Lys Tyr Asn Pro Glu Tyr Ser Val Ala Asn Asp Thr Gly
    210                 215                 220                 
Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala
225                 230                 235                 240 
Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe
                245                 250                 255     
Met Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu
            260                 265                 270         
Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr
        275                 280                 285             
Glu Ser Asp Asn Ser Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu
    290                 295                 300                 
Glu Trp Gly Met Gly Gly Tyr Ile Lys Met Ala Lys Asp Arg Arg Asn
305                 310                 315                 320 
His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val
                325                 330             


<210> 213
<211> 220
<212> PRT
<213> Cercopithecus aethiops

<220> 
<223> cathepsin L mature

<400> 213
Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro Val
 1               5                  10                  15      
Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr Gly
            20                  25                  30          
Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser Leu
        35                  40                  45              
Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu Gly
    50                  55                  60                  
Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Ala Asp Asn
65                  70                  75                  80  
Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu Glu
                85                  90                  95      
Ser Cys Lys Tyr Asn Pro Glu Tyr Ser Val Ala Asn Asp Thr Gly Phe
            100                 105                 110         
Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala Thr
        115                 120                 125             
Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe Met
    130                 135                 140                 
Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu Asp
145                 150                 155                 160 
Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr Glu
                165                 170                 175     
Ser Asp Asn Ser Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu Glu
            180                 185                 190         
Trp Gly Met Gly Gly Tyr Ile Lys Met Ala Lys Asp Arg Arg Asn His
        195                 200                 205             
Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val
    210                 215                 220 


<210> 214
<211> 218
<212> PRT
<213> Gallus gallus

<220> 
<223> cathepsin L proprotein

<400> 214
Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro Val
 1               5                  10                  15      
Lys Asp Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Thr Thr Gly
            20                  25                  30          
Ala Leu Glu Gly Gln His Phe Arg Thr Lys Gly Lys Leu Val Ser Leu
        35                  40                  45              
Ser Glu Gln Asn Leu Val Asp Cys Ser Arg Pro Glu Gly Asn Gln Gly
    50                  55                  60                  
Cys Asn Gly Gly Leu Met Asp Gln Ala Phe Gln Tyr Val Gln Asp Asn
65                  70                  75                  80  
Gly Gly Ile Asp Ser Glu Glu Ser Tyr Pro Tyr Thr Ala Lys Asp Asp
                85                  90                  95      
Glu Asp Cys Arg Tyr Lys Ala Glu Tyr Asn Ala Ala Asn Asp Thr Gly
            100                 105                 110         
Phe Val Asp Ile Pro Gln Gly His Glu Arg Ala Leu Met Lys Ala Val
        115                 120                 125             
Ala Ser Val Gly Pro Val Ser Val Ala Ile Asp Ala Gly His Ser Ser
    130                 135                 140                 
Phe Gln Phe Tyr Gln Ser Gly Ile Tyr Tyr Glu Pro Asp Cys Ser Ser
145                 150                 155                 160 
Glu Asp Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly
                165                 170                 175     
Gly Lys Lys Tyr Trp Ile Val Lys Asn Ser Trp Gly Glu Lys Trp Gly
            180                 185                 190         
Asp Lys Gly Tyr Ile Tyr Met Ala Lys Asp Arg Lys Asn His Cys Gly
        195                 200                 205             
Ile Ala Thr Ala Ala Ser Tyr Pro Leu Val
    210                 215             


<210> 215
<211> 334
<212> PRT
<213> Mus musculus

<220> 
<223> cathepsin L precursor

<400> 215
Met Asn Leu Leu Leu Leu Leu Ala Val Leu Cys Leu Gly Thr Ala Leu
 1               5                  10                  15      
Ala Thr Pro Lys Phe Asp Gln Thr Phe Ser Ala Glu Trp His Gln Trp
            20                  25                  30          
Lys Ser Thr His Arg Arg Leu Tyr Gly Thr Asn Glu Glu Glu Trp Arg
        35                  40                  45              
Arg Ala Ile Trp Glu Lys Asn Met Arg Met Ile Gln Leu His Asn Gly
    50                  55                  60                  
Glu Tyr Ser Asn Gly Gln His Gly Phe Ser Met Glu Met Asn Ala Phe
65                  70                  75                  80  
Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Val Val Asn Gly Tyr Arg
                85                  90                  95      
His Gln Lys His Lys Lys Gly Arg Leu Phe Gln Glu Pro Leu Met Leu
            100                 105                 110         
Lys Ile Pro Lys Ser Val Asp Trp Arg Glu Lys Gly Cys Val Thr Pro
        115                 120                 125             
Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Ser
    130                 135                 140                 
Gly Cys Leu Glu Gly Gln Met Phe Leu Lys Thr Gly Lys Leu Ile Ser
145                 150                 155                 160 
Leu Ser Glu Gln Asn Leu Val Asp Cys Ser His Ala Gln Gly Asn Gln
                165                 170                 175     
Gly Cys Asn Gly Gly Leu Met Asp Phe Ala Phe Gln Tyr Ile Lys Glu
            180                 185                 190         
Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Lys Asp
        195                 200                 205             
Gly Ser Cys Lys Tyr Arg Ala Glu Phe Ala Val Ala Asn Asp Thr Gly
    210                 215                 220                 
Phe Val Asp Ile Pro Gln Gln Glu Lys Ala Leu Met Lys Ala Val Ala
225                 230                 235                 240 
Thr Val Gly Pro Ile Ser Val Ala Met Asp Ala Ser His Pro Ser Leu
                245                 250                 255     
Gln Phe Tyr Ser Ser Gly Ile Tyr Tyr Glu Pro Asn Cys Ser Ser Lys
            260                 265                 270         
Asn Leu Asp His Gly Val Leu Leu Val Gly Tyr Gly Tyr Glu Gly Thr
        275                 280                 285             
Asp Ser Asn Lys Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Ser
    290                 295                 300                 
Glu Trp Gly Met Glu Gly Tyr Ile Lys Ile Ala Lys Asp Arg Asp Asn
305                 310                 315                 320 
His Cys Gly Leu Ala Thr Ala Ala Ser Tyr Pro Val Val Asn
                325                 330                 


<210> 216
<211> 221
<212> PRT
<213> Mus musculus

<220> 
<223> cathepsin L mature

<400> 216
Ile Pro Lys Ser Val Asp Trp Arg Glu Lys Gly Cys Val Thr Pro Val
 1               5                  10                  15      
Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Ser Gly
            20                  25                  30          
Cys Leu Glu Gly Gln Met Phe Leu Lys Thr Gly Lys Leu Ile Ser Leu
        35                  40                  45              
Ser Glu Gln Asn Leu Val Asp Cys Ser His Ala Gln Gly Asn Gln Gly
    50                  55                  60                  
Cys Asn Gly Gly Leu Met Asp Phe Ala Phe Gln Tyr Ile Lys Glu Asn
65                  70                  75                  80  
Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Lys Asp Gly
                85                  90                  95      
Ser Cys Lys Tyr Arg Ala Glu Phe Ala Val Ala Asn Asp Thr Gly Phe
            100                 105                 110         
Val Asp Ile Pro Gln Gln Glu Lys Ala Leu Met Lys Ala Val Ala Thr
        115                 120                 125             
Val Gly Pro Ile Ser Val Ala Met Asp Ala Ser His Pro Ser Leu Gln
    130                 135                 140                 
Phe Tyr Ser Ser Gly Ile Tyr Tyr Glu Pro Asn Cys Ser Ser Lys Asn
145                 150                 155                 160 
Leu Asp His Gly Val Leu Leu Val Gly Tyr Gly Tyr Glu Gly Thr Asp
                165                 170                 175     
Ser Asn Lys Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Ser Glu
            180                 185                 190         
Trp Gly Met Glu Gly Tyr Ile Lys Ile Ala Lys Asp Arg Asp Asn His
        195                 200                 205             
Cys Gly Leu Ala Thr Ala Ala Ser Tyr Pro Val Val Asn
    210                 215                 220     


<210> 217
<211> 314
<212> PRT
<213> Paramecium tetraurelia

<220> 
<223> cathepsin L precursor

<400> 217
Met Met Leu Leu Gly Ala Ser Leu Tyr Leu Asn Asn Thr Gln Glu Val
 1               5                  10                  15      
Ser Asp Glu Ile Asp Thr Ala Asn Leu Tyr Ala Asn Trp Lys Met Lys
            20                  25                  30          
Tyr Asn Arg Arg Tyr Thr Asn Gln Arg Asp Glu Met Tyr Arg Tyr Lys
        35                  40                  45              
Val Phe Thr Asp Asn Leu Asn Tyr Ile Arg Ala Phe Tyr Glu Ser Pro
    50                  55                  60                  
Glu Glu Ala Thr Phe Thr Leu Glu Leu Asn Gln Phe Ala Asp Met Ser
65                  70                  75                  80  
Gln Gln Glu Phe Ala Gln Thr Tyr Leu Ser Leu Lys Val Pro Arg Thr
                85                  90                  95      
Ala Lys Leu Asn Ala Ala Asn Ser Asn Phe Gln Tyr Lys Gly Ala Glu
            100                 105                 110         
Val Asp Trp Thr Asp Asn Lys Lys Val Lys Tyr Pro Ala Val Lys Asn
        115                 120                 125             
Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Ser Ala Val Gly Ala Leu
    130                 135                 140                 
Glu Ile Asn Thr Asp Ile Glu Leu Asn Arg Lys Tyr Glu Leu Ser Glu
145                 150                 155                 160 
Gln Asp Leu Val Asp Cys Ser Gly Pro Tyr Asp Asn Asp Gly Cys Asn
                165                 170                 175     
Gly Gly Trp Met Asp Ser Ala Phe Glu Tyr Val Ala Asp Asn Gly Leu
            180                 185                 190         
Ala Glu Ala Lys Asp Tyr Pro Tyr Thr Ala Lys Asp Gly Thr Cys Lys
        195                 200                 205             
Thr Ser Val Lys Arg Pro Tyr Thr His Val Gln Gly Phe Lys Asp Ile
    210                 215                 220                 
Asp Ser Cys Asp Glu Leu Ala Gln Thr Ile Gln Glu Arg Thr Val Ala
225                 230                 235                 240 
Val Ala Val Asp Ala Asn Pro Trp Gln Phe Tyr Arg Ser Gly Val Leu
                245                 250                 255     
Ser Lys Cys Thr Lys Asn Leu Asn His Gly Val Val Leu Val Gly Val
            260                 265                 270         
Gln Ala Asp Gly Ala Trp Lys Ile Arg Asn Ser Trp Gly Ser Ser Trp
        275                 280                 285             
Gly Glu Ala Gly His Ile Arg Leu Ala Gly Gly Asp Thr Cys Gly Ile
    290                 295                 300                 
Cys Ala Ala Pro Ser Phe Pro Ile Leu Gly
305                 310                 


<210> 218
<211> 205
<212> PRT
<213> Paramecium tetraurelia

<220> 
<223> cathepsin L mature

<400> 218
Gly Ala Glu Val Asp Trp Thr Asp Asn Lys Lys Val Lys Tyr Pro Ala
 1               5                  10                  15      
Val Lys Asn Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Ser Ala Val
            20                  25                  30          
Gly Ala Leu Glu Ile Asn Thr Asp Ile Glu Leu Asn Arg Lys Tyr Glu
        35                  40                  45              
Leu Ser Glu Gln Asp Leu Val Asp Cys Ser Gly Pro Tyr Asp Asn Asp
    50                  55                  60                  
Gly Cys Asn Gly Gly Trp Met Asp Ser Ala Phe Glu Tyr Val Ala Asp
65                  70                  75                  80  
Asn Gly Leu Ala Glu Ala Lys Asp Tyr Pro Tyr Thr Ala Lys Asp Gly
                85                  90                  95      
Thr Cys Lys Thr Ser Val Lys Arg Pro Tyr Thr His Val Gln Gly Phe
            100                 105                 110         
Lys Asp Ile Asp Ser Cys Asp Glu Leu Ala Gln Thr Ile Gln Glu Arg
        115                 120                 125             
Thr Val Ala Val Ala Val Asp Ala Asn Pro Trp Gln Phe Tyr Arg Ser
    130                 135                 140                 
Gly Val Leu Ser Lys Cys Thr Lys Asn Leu Asn His Gly Val Val Leu
145                 150                 155                 160 
Val Gly Val Gln Ala Asp Gly Ala Trp Lys Ile Arg Asn Ser Trp Gly
                165                 170                 175     
Ser Ser Trp Gly Glu Ala Gly His Ile Arg Leu Ala Gly Gly Asp Thr
            180                 185                 190         
Cys Gly Ile Cys Ala Ala Pro Ser Phe Pro Ile Leu Gly
        195                 200                 205 


<210> 219
<211> 334
<212> PRT
<213> Sus scrofa

<220> 
<223> cathepsin L precursor

<400> 219
Met Lys Pro Ser Leu Phe Leu Thr Ala Leu Cys Leu Gly Ile Ala Ser
 1               5                  10                  15      
Ala Ala Pro Lys Leu Asp Gln Asn Leu Asp Ala Asp Trp Tyr Lys Trp
            20                  25                  30          
Lys Ala Thr His Gly Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg
        35                  40                  45              
Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln
    50                  55                  60                  
Glu Tyr Ser Gln Gly Lys His Gly Phe Ser Met Ala Met Asn Ala Phe
65                  70                  75                  80  
Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln
                85                  90                  95      
Asn Gln Lys His Lys Lys Gly Lys Val Phe His Glu Ser Leu Val Leu
            100                 105                 110         
Glu Val Pro Lys Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Ala
        115                 120                 125             
Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr
    130                 135                 140                 
Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser
145                 150                 155                 160 
Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Arg Pro Gln Gly Asn Gln
                165                 170                 175     
Gly Cys Asn Gly Gly Leu Met Asp Asn Ala Phe Gln Tyr Val Lys Asp
            180                 185                 190         
Asn Gly Gly Leu Asp Thr Glu Glu Ser Tyr Pro Tyr Leu Gly Arg Glu
        195                 200                 205             
Thr Asn Ser Cys Thr Tyr Lys Pro Glu Cys Ser Ala Ala Asn Asp Thr
    210                 215                 220                 
Gly Phe Val Asp Ile Pro Gln Arg Glu Lys Ala Leu Met Lys Ala Val
225                 230                 235                 240 
Ala Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Ser Ser
                245                 250                 255     
Phe Gln Phe Tyr Lys Ser Gly Ile Tyr Tyr Asp Pro Asp Cys Ser Ser
            260                 265                 270         
Lys Asp Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly
        275                 280                 285             
Thr Asp Ser Asn Ser Ser Lys Phe Trp Ile Val Lys Asn Ser Trp Gly
    290                 295                 300                 
Pro Glu Trp Gly Trp Asn Gly Tyr Val Lys Met Ala Lys Asp Gln Asn
305                 310                 315                 320 
Asn His Cys Gly Ile Ser Thr Ala Ala Ser Tyr Pro Thr Val
                325                 330                 


<210> 220
<211> 217

<212> PRT
<213> Sus scrofa

<220> 
<223> cathepsin L mature

<400> 220
Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Ala Val Lys Asn Gln Gly
 1               5                  10                  15      
Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr Gly Ala Leu Glu Gly
            20                  25                  30          
Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser Leu Ser Glu Gln Asn
        35                  40                  45              
Leu Val Asp Cys Ser Arg Pro Gln Gly Asn Gln Gly Cys Asn Gly Gly
    50                  55                  60                  
Leu Met Asp Asn Ala Phe Gln Tyr Val Lys Asp Asn Gly Gly Leu Asp
65                  70                  75                  80  
Thr Glu Glu Ser Tyr Pro Tyr Leu Gly Arg Glu Thr Asn Ser Cys Thr
                85                  90                  95      
Tyr Lys Pro Glu Cys Ser Ala Ala Asn Asp Thr Gly Phe Val Asp Ile
            100                 105                 110         
Pro Gln Arg Glu Lys Ala Leu Met Lys Ala Val Ala Thr Val Gly Pro
        115                 120                 125             
Ile Ser Val Ala Ile Asp Ala Gly His Ser Ser Phe Gln Phe Tyr Lys
    130                 135                 140                 
Ser Gly Ile Tyr Tyr Asp Pro Asp Cys Ser Ser Lys Asp Leu Asp His
145                 150                 155                 160 
Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly Thr Asp Ser Asn Ser
                165                 170                 175     
Ser Lys Phe Trp Ile Val Lys Asn Ser Trp Gly Pro Glu Trp Gly Trp
            180                 185                 190         
Asn Gly Tyr Val Lys Met Ala Lys Asp Gln Asn Asn His Cys Gly Ile
        195                 200                 205             
Ser Thr Ala Ala Ser Tyr Pro Thr Val
    210                 215         


<210> 221
<211> 334
<212> PRT
<213> Rattus norvegicus

<220> 
<223> cathepsin L precursor

<400> 221
Met Thr Pro Leu Leu Leu Leu Ala Val Leu Cys Leu Gly Thr Ala Leu
 1               5                  10                  15      
Ala Thr Pro Lys Phe Asp Gln Thr Phe Asn Ala Gln Trp His Gln Trp
            20                  25                  30          
Lys Ser Thr His Arg Arg Leu Tyr Gly Thr Asn Glu Glu Glu Trp Arg
        35                  40                  45              
Arg Ala Val Trp Glu Lys Asn Met Arg Met Ile Gln Leu His Asn Gly
    50                  55                  60                  
Glu Tyr Ser Asn Gly Lys His Gly Phe Thr Met Glu Met Asn Ala Phe
65                  70                  75                  80  
Gly Asp Met Thr Asn Glu Glu Phe Arg Gln Ile Val Asn Gly Tyr Arg
                85                  90                  95      
His Gln Lys His Lys Lys Gly Arg Leu Phe Gln Glu Pro Leu Met Leu
            100                 105                 110         
Gln Ile Pro Lys Thr Val Asp Trp Arg Glu Lys Gly Cys Val Thr Pro
        115                 120                 125             
Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Ser
    130                 135                 140                 
Gly Cys Leu Glu Gly Gln Met Phe Leu Lys Thr Gly Lys Leu Ile Ser
145                 150                 155                 160 
Leu Ser Glu Gln Asn Leu Val Asp Cys Ser His Asp Gln Gly Asn Gln
                165                 170                 175     
Gly Cys Asn Gly Gly Leu Met Asp Phe Ala Phe Gln Tyr Ile Lys Glu
            180                 185                 190         
Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Lys Asp
        195                 200                 205             
Gly Ser Cys Lys Tyr Arg Ala Glu Tyr Ala Val Ala Asn Asp Thr Gly
    210                 215                 220                 
Phe Val Asp Ile Pro Gln Gln Glu Lys Ala Leu Met Lys Ala Val Ala
225                 230                 235                 240 
Thr Val Gly Pro Ile Ser Val Ala Met Asp Ala Ser His Pro Ser Leu
                245                 250                 255     
Gln Phe Tyr Ser Ser Gly Ile Tyr Tyr Glu Pro Asn Cys Ser Ser Lys
            260                 265                 270         
Asp Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Tyr Glu Gly Thr
        275                 280                 285             
Asp Ser Asn Lys Asp Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Lys
    290                 295                 300                 
Glu Trp Gly Met Asp Gly Tyr Ile Lys Ile Ala Lys Asp Arg Asn Asn
305                 310                 315                 320 
His Cys Gly Leu Ala Thr Ala Ala Ser Tyr Pro Ile Val Asn
                325                 330                 


<210> 222
<211> 221
<212> PRT
<213> Rattus norvegicus

<220> 
<223> cathepsin L mature

<400> 222
Ile Pro Lys Thr Val Asp Trp Arg Glu Lys Gly Cys Val Thr Pro Val
 1               5                  10                  15      
Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Ser Gly
            20                  25                  30          
Cys Leu Glu Gly Gln Met Phe Leu Lys Thr Gly Lys Leu Ile Ser Leu
        35                  40                  45              
Ser Glu Gln Asn Leu Val Asp Cys Ser His Asp Gln Gly Asn Gln Gly
    50                  55                  60                  
Cys Asn Gly Gly Leu Met Asp Phe Ala Phe Gln Tyr Ile Lys Glu Asn
65                  70                  75                  80  
Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Lys Asp Gly
                85                  90                  95      
Ser Cys Lys Tyr Arg Ala Glu Tyr Ala Val Ala Asn Asp Thr Gly Phe
            100                 105                 110         
Val Asp Ile Pro Gln Gln Glu Lys Ala Leu Met Lys Ala Val Ala Thr
        115                 120                 125             
Val Gly Pro Ile Ser Val Ala Met Asp Ala Ser His Pro Ser Leu Gln
    130                 135                 140                 
Phe Tyr Ser Ser Gly Ile Tyr Tyr Glu Pro Asn Cys Ser Ser Lys Asp
145                 150                 155                 160 
Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Tyr Glu Gly Thr Asp
                165                 170                 175     
Ser Asn Lys Asp Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Lys Glu
            180                 185                 190         
Trp Gly Met Asp Gly Tyr Ile Lys Ile Ala Lys Asp Arg Asn Asn His
        195                 200                 205             
Cys Gly Leu Ala Thr Ala Ala Ser Tyr Pro Ile Val Asn
    210                 215                 220     


<210> 223
<211> 217
<212> PRT
<213> Ovis aries

<220> 
<223> cathepsin L mature

<400> 223
Val Pro Lys Ser Val Asp Trp Thr Lys Lys Gly Tyr Val Thr Pro Val
 1               5                  10                  15      
Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr Gly
            20                  25                  30          
Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Lys Leu Val Ser Leu
        35                  40                  45              
Ser Glu Gln Asn Leu Val Asp Ser Ser Arg Pro Gln Gly Asn Gln Gly
    50                  55                  60                  
Cys Asn Gly Gly Leu Met Asp Asn Ala Phe Gln Tyr Ile Lys Glu Asn
65                  70                  75                  80  
Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Asp Thr
                85                  90                  95      
Ser Cys Asn Tyr Lys Pro Glu Tyr Ser Ala Ala Lys Asp Thr Gly Phe
            100                 105                 110         
Val Asp Ile Pro Gln Arg Glu Lys Ala Leu Met Lys Ala Val Ala Thr
        115                 120                 125             
Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Ser Ser Phe Gln
    130                 135                 140                 
Phe Tyr Lys Ser Gly Ile Tyr Tyr Asp Pro Asp Cys Ser Ser Lys Asp
145                 150                 155                 160 
Leu Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Gly Thr Asn
                165                 170                 175     
Asn Lys Phe Trp Ile Val Lys Asn Ser Trp Gly Pro Glu Trp Gly Asn
            180                 185                 190         
Lys Gly Tyr Val Lys Met Ala Lys Asp Gln Asn Asn His Cys Gly Ile
        195                 200                 205             
Ala Thr Ala Ala Ser Tyr Pro Thr Val
    210                 215         


<210> 224
<211> 6630
<212> DNA
<213> Artificial Sequence

<220> 
<223> HZ24 with PH20 and DHFR (Gen1/Gen2)

<400> 224
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta 60
ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc 120
aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg 180
gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc 240
gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat 300
agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc 360
ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga 420
cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg 480
gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac 540
caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt 600
caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc 660
cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc 720
tcgtttagtg aaccgtcaga tcactagaag ctttattgcg gtagtttatc acagttaaat 780
tgctaacgca gtcagtgctt ctgacacaac agtctcgaac ttaagctgca gaagttggtc 840
gtgaggcact gggcaggtaa gtatcaaggt tacaagacag gtttaaggag accaatagaa 900
actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta ttggtcttac 960
tgacatccac tttgcctttc tctccacagg tgtccactcc cagttcaatt acagctctta 1020
aggctagagt acttaatacg actcactata ggctagcatg ggagtgctaa aattcaagca 1080
catctttttc agaagctttg ttaaatcaag tggagtatcc cagatagttt tcaccttcct 1140
tctgattcca tgttgcttga ctctgaattt cagagcacct cctgttattc caaatgtgcc 1200
tttcctctgg gcctggaatg ccccaagtga attttgtctt ggaaaatttg atgagccact 1260
agatatgagc ctcttctctt tcataggaag cccccgaata aacgccaccg ggcaaggtgt 1320
tacaatattt tatgttgata gacttggcta ctatccttac atagattcaa tcacaggagt 1380
aactgtgaat ggaggaatcc cccagaagat ttccttacaa gaccatctgg acaaagctaa 1440
gaaagacatt acattttata tgccagtaga caatttggga atggctgtta ttgactggga 1500
agaatggaga cccacttggg caagaaactg gaaacctaaa gatgtttaca agaataggtc 1560
tattgaattg gttcagcaac aaaatgtaca acttagtctc acagaggcca ctgagaaagc 1620
aaaacaagaa tttgaaaagg cagggaagga tttcctggta gagactataa aattgggaaa 1680
attacttcgg ccaaatcact tgtggggtta ttatcttttt ccggattgtt acaaccatca 1740
ctataagaaa cccggttaca atggaagttg cttcaatgta gaaataaaaa gaaatgatga 1800
tctcagctgg ttgtggaatg aaagcactgc tctttaccca tccatttatt tgaacactca 1860
gcagtctcct gtagctgcta cactctatgt gcgcaatcga gttcgggaag ccatcagagt 1920
ttccaaaata cctgatgcaa aaagtccact tccggttttt gcatataccc gcatagtttt 1980
tactgatcaa gttttgaaat tcctttctca agatgaactt gtgtatacat ttggcgaaac 2040
tgttgctctg ggtgcttctg gaattgtaat atggggaacc ctcagtataa tgcgaagtat 2100
gaaatcttgc ttgctcctag acaattacat ggagactata ctgaatcctt acataatcaa 2160
cgtcacacta gcagccaaaa tgtgtagcca agtgctttgc caggagcaag gagtgtgtat 2220
aaggaaaaac tggaattcaa gtgactatct tcacctcaac ccagataatt ttgctattca 2280
acttgagaaa ggtggaaagt tcacagtacg tggaaaaccg acacttgaag acctggagca 2340
attttctgaa aaattttatt gcagctgtta tagcaccttg agttgtaagg agaaagctga 2400
tgtaaaagac actgatgctg ttgatgtgtg tattgctgat ggtgtctgta tagatgcttt 2460
tctaaaacct cccatggaga cagaagaacc tcaaattttc tactgaggat ccatagctaa 2520
cgcccctctc cctccccccc ccctaacgtt actggccgaa gccgcttgga ataaggccgg 2580
tgtgcgtttg tctatatgtt attttccacc atattgccgt cttttggcaa tgtgagggcc 2640
cggaaacctg gccctgtctt cttgacgagc attcctaggg gtctttcccc tctcgccaaa 2700
ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga 2760
caaacaacgt ctgtagcgac cctttgcagg cagcggaacc ccccacctgg cgacaggtgc 2820
ctctgcggcc aaaagccacg tgtataagat acacctgcaa aggcggcaca accccagtgc 2880
cacgttgtga gttggatagt tgtggaaaga gtcaaatggc tctcctcaag cgtattcaac 2940
aaggggctga aggatgccca gaaggtaccc cattgtatgg gatctgatct ggggcctcgg 3000
tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaaac gtctaggccc cccgaaccac 3060
ggggacgtgg ttttcctttg aaaaacacga tgataagctt gccacaaccc acagcggccg 3120
ctgccatcat ggttcgacca ttgaactgca tcgtcgccgt gtcccaaaat atggggattg 3180
gcaagaacgg agacctaccc tggcctccgc tcaggaacga gttcaagtac ttccaaagaa 3240
tgaccacaac ctcttcagtg gaaggtaaac agaatctggt gattatgggt aggaaaacct 3300
ggttctccat tcctgagaag aatcgacctt taaaggacag aattaatata gttctcagta 3360
gagaactcaa agaaccacca cgaggagctc attttcttgc caaaagtttg gatgatgcct 3420
taagacttat tgaacaaccg gaattggcaa gtaaagtaga catggtttgg atagtcggag 3480
gcagttctgt ttaccaggaa gccatgaatc aaccaggcca cctcagactc tttgtgacaa 3540
ggatcatgca ggaatttgaa agtgacacgt ttttcccaga aattgatttg gggaaatata 3600
aacttctccc agaataccca ggcgtcctct ctgaggtcca ggaggaaaaa ggcatcaagt 3660
ataagtttga agtctacgag aagaaagact aaacgcgtgg tacctctaga gtcgacccgg 3720
gcggccgctt cgagcagaca tgataagata cattgatgag tttggacaaa ccacaactag 3780
aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac 3840
cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt 3900
tcagggggag atgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtaaaat 3960
cgataaggat ccgggctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca 4020
gttgcgcagc ctgaatggcg aatggacgcg ccctgtagcg gcgcattaag cgcggcgggt 4080
gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc 4140
gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg 4200
gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat 4260
tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg 4320
ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct 4380
atctcggtct attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa 4440
aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac gcttacaatt 4500
tcctgatgcg gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atatggtgca 4560
ctctcagtac aatctgctct gatgccgcat agttaagcca gccccgacac ccgccaacac 4620
ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga 4680
ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac 4740
gaaagggcct cgtgatacgc ctatttttat aggttaatgt catgataata atggtttctt 4800
agacgtcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct 4860
aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat 4920
attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg 4980
cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg 5040
aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc 5100
ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat 5160
gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact 5220
attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca 5280
tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact 5340
tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg 5400
atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg 5460
agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg 5520
aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg 5580
caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag 5640
ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc 5700
gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga 5760
tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat 5820
atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc 5880
tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag 5940
accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct 6000
gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac 6060
caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat actgttcttc 6120
tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg 6180
ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt 6240
tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt 6300
gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc 6360
tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca 6420
gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata 6480
gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg 6540
ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct 6600
ggccttttgc tcacatggct cgacagatct                                  6630



<210> 225
<211> 482

<212> PRT
<213> Homo sapiens

<220> 
<223> precursor soluble rHuPH20

<400> 225
Met Gly Val Leu Lys Phe Lys His Ile Phe Phe Arg Ser Phe Val Lys
 1               5                  10                  15      
Ser Ser Gly Val Ser Gln Ile Val Phe Thr Phe Leu Leu Ile Pro Cys
            20                  25                  30          
Cys Leu Thr Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro
        35                  40                  45              
Phe Leu Trp Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe
    50                  55                  60                  
Asp Glu Pro Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg
65                  70                  75                  80  
Ile Asn Ala Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu
                85                  90                  95      
Gly Tyr Tyr Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly
            100                 105                 110         
Gly Ile Pro Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys
        115                 120                 125             
Lys Asp Ile Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val
    130                 135                 140                 
Ile Asp Trp Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro
145                 150                 155                 160 
Lys Asp Val Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn
                165                 170                 175     
Val Gln Leu Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe
            180                 185                 190         
Glu Lys Ala Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys
        195                 200                 205             
Leu Leu Arg Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys
    210                 215                 220                 
Tyr Asn His His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn
225                 230                 235                 240 
Val Glu Ile Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser
                245                 250                 255     
Thr Ala Leu Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val
            260                 265                 270         
Ala Ala Thr Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val
        275                 280                 285             
Ser Lys Ile Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr
    290                 295                 300                 
Arg Ile Val Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu
305                 310                 315                 320 
Leu Val Tyr Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile
                325                 330                 335     
Val Ile Trp Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu
            340                 345                 350         
Leu Leu Asp Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn
        355                 360                 365             
Val Thr Leu Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln
    370                 375                 380                 
Gly Val Cys Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu
385                 390                 395                 400 
Asn Pro Asp Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Phe Thr
                405                 410                 415     
Val Arg Gly Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys
            420                 425                 430         
Phe Tyr Cys Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp
        435                 440                 445             
Val Lys Asp Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys
    450                 455                 460                 
Ile Asp Ala Phe Leu Lys Pro Pro Met Glu Thr Glu Glu Pro Gln Ile
465                 470                 475                 480 
Phe Tyr
        


<210> 226
<211> 447
<212> PRT
<213> Homo sapiens

<220> 
<223> soluble rHuPH20 1-447

<400> 226
Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro Phe Leu Trp
 1               5                  10                  15      
Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe Asp Glu Pro
            20                  25                  30          
Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg Ile Asn Ala
        35                  40                  45              
Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu Gly Tyr Tyr
    50                  55                  60                  
Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly Gly Ile Pro
65                  70                  75                  80  
Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys Lys Asp Ile
                85                  90                  95      
Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val Ile Asp Trp
            100                 105                 110         
Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro Lys Asp Val
        115                 120                 125             
Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn Val Gln Leu
    130                 135                 140                 
Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe Glu Lys Ala
145                 150                 155                 160 
Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys Leu Leu Arg
                165                 170                 175     
Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys Tyr Asn His
            180                 185                 190         
His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn Val Glu Ile
        195                 200                 205             
Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser Thr Ala Leu
    210                 215                 220                 
Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val Ala Ala Thr
225                 230                 235                 240 
Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val Ser Lys Ile
                245                 250                 255     
Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr Arg Ile Val
            260                 265                 270         
Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu Leu Val Tyr
        275                 280                 285             
Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile Val Ile Trp
    290                 295                 300                 
Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu Leu Leu Asp
305                 310                 315                 320 
Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn Val Thr Leu
                325                 330                 335     
Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln Gly Val Cys
            340                 345                 350         
Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu Asn Pro Asp
        355                 360                 365             
Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Phe Thr Val Arg Gly
    370                 375                 380                 
Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys Phe Tyr Cys
385                 390                 395                 400 
Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp Val Lys Asp
                405                 410                 415     
Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys Ile Asp Ala
            420                 425                 430         
Phe Leu Lys Pro Pro Met Glu Thr Glu Glu Pro Gln Ile Phe Tyr
        435                 440                 445         


<210> 227
<211> 446
<212> PRT
<213> Homo sapiens

<220> 
<223> soluble rHuPH20 1-446

<400> 227
Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro Phe Leu Trp
 1               5                  10                  15      
Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe Asp Glu Pro
            20                  25                  30          
Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg Ile Asn Ala
        35                  40                  45              
Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu Gly Tyr Tyr
    50                  55                  60                  
Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly Gly Ile Pro
65                  70                  75                  80  
Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys Lys Asp Ile
                85                  90                  95      
Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val Ile Asp Trp
            100                 105                 110         
Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro Lys Asp Val
        115                 120                 125             
Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn Val Gln Leu
    130                 135                 140                 
Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe Glu Lys Ala
145                 150                 155                 160 
Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys Leu Leu Arg
                165                 170                 175     
Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys Tyr Asn His
            180                 185                 190         
His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn Val Glu Ile
        195                 200                 205             
Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser Thr Ala Leu
    210                 215                 220                 
Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val Ala Ala Thr
225                 230                 235                 240 
Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val Ser Lys Ile
                245                 250                 255     
Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr Arg Ile Val
            260                 265                 270         
Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu Leu Val Tyr
        275                 280                 285             
Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile Val Ile Trp
    290                 295                 300                 
Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu Leu Leu Asp
305                 310                 315                 320 
Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn Val Thr Leu
                325                 330                 335     
Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln Gly Val Cys
            340                 345                 350         
Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu Asn Pro Asp
        355                 360                 365             
Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Phe Thr Val Arg Gly
    370                 375                 380                 
Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys Phe Tyr Cys
385                 390                 395                 400 
Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp Val Lys Asp
                405                 410                 415     
Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys Ile Asp Ala
            420                 425                 430         
Phe Leu Lys Pro Pro Met Glu Thr Glu Glu Pro Gln Ile Phe
        435                 440                 445     


<210> 228
<211> 445
<212> PRT
<213> Homo sapiens

<220> 
<223> soluble rHuPH20 1-445

<400> 228
Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro Phe Leu Trp
 1               5                  10                  15      
Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe Asp Glu Pro
            20                  25                  30          
Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg Ile Asn Ala
        35                  40                  45              
Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu Gly Tyr Tyr
    50                  55                  60                  
Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly Gly Ile Pro
65                  70                  75                  80  
Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys Lys Asp Ile
                85                  90                  95      
Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val Ile Asp Trp
            100                 105                 110         
Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro Lys Asp Val
        115                 120                 125             
Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn Val Gln Leu
    130                 135                 140                 
Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe Glu Lys Ala
145                 150                 155                 160 
Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys Leu Leu Arg
                165                 170                 175     
Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys Tyr Asn His
            180                 185                 190         
His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn Val Glu Ile

        195                 200                 205             
Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser Thr Ala Leu
    210                 215                 220                 
Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val Ala Ala Thr
225                 230                 235                 240 
Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val Ser Lys Ile
                245                 250                 255     
Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr Arg Ile Val
            260                 265                 270         
Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu Leu Val Tyr
        275                 280                 285             
Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile Val Ile Trp
    290                 295                 300                 
Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu Leu Leu Asp
305                 310                 315                 320 
Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn Val Thr Leu
                325                 330                 335     
Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln Gly Val Cys
            340                 345                 350         
Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu Asn Pro Asp
        355                 360                 365             
Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Phe Thr Val Arg Gly
    370                 375                 380                 
Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys Phe Tyr Cys
385                 390                 395                 400 
Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp Val Lys Asp
                405                 410                 415     
Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys Ile Asp Ala
            420                 425                 430         
Phe Leu Lys Pro Pro Met Glu Thr Glu Glu Pro Gln Ile
        435                 440                 445 


<210> 229
<211> 444
<212> PRT
<213> Homo sapiens

<220> 
<223> soluble rHuPH20 1-444

<400> 229
Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro Phe Leu Trp
 1               5                  10                  15      
Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe Asp Glu Pro
            20                  25                  30          
Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg Ile Asn Ala
        35                  40                  45              
Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu Gly Tyr Tyr
    50                  55                  60                  
Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly Gly Ile Pro
65                  70                  75                  80  
Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys Lys Asp Ile
                85                  90                  95      
Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val Ile Asp Trp
            100                 105                 110         
Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro Lys Asp Val
        115                 120                 125             
Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn Val Gln Leu
    130                 135                 140                 
Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe Glu Lys Ala
145                 150                 155                 160 
Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys Leu Leu Arg
                165                 170                 175     
Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys Tyr Asn His
            180                 185                 190         
His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn Val Glu Ile
        195                 200                 205             
Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser Thr Ala Leu
    210                 215                 220                 
Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val Ala Ala Thr
225                 230                 235                 240 
Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val Ser Lys Ile
                245                 250                 255     
Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr Arg Ile Val
            260                 265                 270         
Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu Leu Val Tyr
        275                 280                 285             
Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile Val Ile Trp
    290                 295                 300                 
Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu Leu Leu Asp
305                 310                 315                 320 
Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn Val Thr Leu
                325                 330                 335     
Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln Gly Val Cys
            340                 345                 350         
Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu Asn Pro Asp
        355                 360                 365             
Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Phe Thr Val Arg Gly
    370                 375                 380                 
Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys Phe Tyr Cys
385                 390                 395                 400 
Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp Val Lys Asp
                405                 410                 415     
Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys Ile Asp Ala
            420                 425                 430         
Phe Leu Lys Pro Pro Met Glu Thr Glu Glu Pro Gln
        435                 440                 


<210> 230
<211> 443
<212> PRT
<213> Homo sapiens

<220> 
<223> soluble rHuPH20 1-443

<400> 230
Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro Phe Leu Trp
 1               5                  10                  15      
Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe Asp Glu Pro
            20                  25                  30          
Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg Ile Asn Ala
        35                  40                  45              
Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu Gly Tyr Tyr
    50                  55                  60                  
Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly Gly Ile Pro
65                  70                  75                  80  
Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys Lys Asp Ile
                85                  90                  95      
Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val Ile Asp Trp
            100                 105                 110         
Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro Lys Asp Val
        115                 120                 125             
Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn Val Gln Leu
    130                 135                 140                 
Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe Glu Lys Ala
145                 150                 155                 160 
Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys Leu Leu Arg
                165                 170                 175     
Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys Tyr Asn His
            180                 185                 190         
His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn Val Glu Ile
        195                 200                 205             
Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser Thr Ala Leu
    210                 215                 220                 
Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val Ala Ala Thr
225                 230                 235                 240 
Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val Ser Lys Ile
                245                 250                 255     
Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr Arg Ile Val
            260                 265                 270         
Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu Leu Val Tyr
        275                 280                 285             
Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile Val Ile Trp
    290                 295                 300                 
Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu Leu Leu Asp
305                 310                 315                 320 
Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn Val Thr Leu
                325                 330                 335     
Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln Gly Val Cys
            340                 345                 350         
Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu Asn Pro Asp
        355                 360                 365             
Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Phe Thr Val Arg Gly
    370                 375                 380                 
Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys Phe Tyr Cys
385                 390                 395                 400 
Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp Val Lys Asp
                405                 410                 415     
Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys Ile Asp Ala
            420                 425                 430         
Phe Leu Lys Pro Pro Met Glu Thr Glu Glu Pro
        435                 440             


<210> 231
<211> 442
<212> PRT
<213> Homo sapiens

<220> 
<223> soluble rHuPH20 1-442

<400> 231
Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro Phe Leu Trp
 1               5                  10                  15      
Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe Asp Glu Pro
            20                  25                  30          
Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg Ile Asn Ala
        35                  40                  45              
Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu Gly Tyr Tyr
    50                  55                  60                  
Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly Gly Ile Pro
65                  70                  75                  80  
Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys Lys Asp Ile
                85                  90                  95      
Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val Ile Asp Trp
            100                 105                 110         
Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro Lys Asp Val
        115                 120                 125             
Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn Val Gln Leu
    130                 135                 140                 
Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe Glu Lys Ala
145                 150                 155                 160 
Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys Leu Leu Arg
                165                 170                 175     
Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys Tyr Asn His
            180                 185                 190         
His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn Val Glu Ile
        195                 200                 205             
Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser Thr Ala Leu
    210                 215                 220                 
Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val Ala Ala Thr
225                 230                 235                 240 
Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val Ser Lys Ile
                245                 250                 255     
Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr Arg Ile Val
            260                 265                 270         
Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu Leu Val Tyr
        275                 280                 285             
Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile Val Ile Trp
    290                 295                 300                 
Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu Leu Leu Asp
305                 310                 315                 320 
Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn Val Thr Leu
                325                 330                 335     
Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln Gly Val Cys
            340                 345                 350         
Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu Asn Pro Asp
        355                 360                 365             
Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Phe Thr Val Arg Gly
    370                 375                 380                 
Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys Phe Tyr Cys
385                 390                 395                 400 
Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp Val Lys Asp
                405                 410                 415     
Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys Ile Asp Ala
            420                 425                 430         
Phe Leu Lys Pro Pro Met Glu Thr Glu Glu
        435                 440         


<210> 232
<211> 509
<212> PRT
<213> Homo sapiens

<220> 
<223> precursor PH20

<400> 232
Met Gly Val Leu Lys Phe Lys His Ile Phe Phe Arg Ser Phe Val Lys
 1               5                  10                  15      
Ser Ser Gly Val Ser Gln Ile Val Phe Thr Phe Leu Leu Ile Pro Cys
            20                  25                  30          
Cys Leu Thr Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro
        35                  40                  45              
Phe Leu Trp Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe
    50                  55                  60                  
Asp Glu Pro Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg
65                  70                  75                  80  
Ile Asn Ala Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu
                85                  90                  95      
Gly Tyr Tyr Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly
            100                 105                 110         
Gly Ile Pro Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys
        115                 120                 125             
Lys Asp Ile Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val
    130                 135                 140                 
Ile Asp Trp Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro
145                 150                 155                 160 
Lys Asp Val Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn
                165                 170                 175     
Val Gln Leu Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe
            180                 185                 190         
Glu Lys Ala Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys
        195                 200                 205             
Leu Leu Arg Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys
    210                 215                 220                 
Tyr Asn His His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn
225                 230                 235                 240 
Val Glu Ile Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser
                245                 250                 255     
Thr Ala Leu Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val
            260                 265                 270         
Ala Ala Thr Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val
        275                 280                 285             
Ser Lys Ile Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr
    290                 295                 300                 
Arg Ile Val Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu
305                 310                 315                 320 
Leu Val Tyr Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile
                325                 330                 335     
Val Ile Trp Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu
            340                 345                 350         
Leu Leu Asp Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn
        355                 360                 365             
Val Thr Leu Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln
    370                 375                 380                 
Gly Val Cys Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu
385                 390                 395                 400 
Asn Pro Asp Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Phe Thr
                405                 410                 415     
Val Arg Gly Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys
            420                 425                 430         
Phe Tyr Cys Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp
        435                 440                 445             
Val Lys Asp Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys
    450                 455                 460                 
Ile Asp Ala Phe Leu Lys Pro Pro Met Glu Thr Glu Glu Pro Gln Ile
465                 470                 475                 480 
Phe Tyr Asn Ala Ser Pro Ser Thr Leu Ser Ala Thr Met Phe Ile Val
                485                 490                 495     
Ser Ile Leu Phe Leu Ile Ile Ser Ser Val Ala Ser Leu
            500                 505                 


<210> 233
<211> 474
<212> PRT
<213> Homo sapiens

<220> 
<223> mature PH20

<400> 233
Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro Phe Leu Trp
 1               5                  10                  15      
Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe Asp Glu Pro
            20                  25                  30          
Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg Ile Asn Ala
        35                  40                  45              
Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu Gly Tyr Tyr
    50                  55                  60                  
Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly Gly Ile Pro

65                  70                  75                  80  
Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys Lys Asp Ile
                85                  90                  95      
Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val Ile Asp Trp
            100                 105                 110         
Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro Lys Asp Val
        115                 120                 125             
Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn Val Gln Leu
    130                 135                 140                 
Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe Glu Lys Ala
145                 150                 155                 160 
Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys Leu Leu Arg
                165                 170                 175     
Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys Tyr Asn His
            180                 185                 190         
His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn Val Glu Ile
        195                 200                 205             
Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser Thr Ala Leu
    210                 215                 220                 
Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val Ala Ala Thr
225                 230                 235                 240 
Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val Ser Lys Ile
                245                 250                 255     
Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr Arg Ile Val
            260                 265                 270         
Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu Leu Val Tyr
        275                 280                 285             
Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile Val Ile Trp
    290                 295                 300                 
Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu Leu Leu Asp
305                 310                 315                 320 
Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn Val Thr Leu
                325                 330                 335     
Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln Gly Val Cys
            340                 345                 350         
Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu Asn Pro Asp
        355                 360                 365             
Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Phe Thr Val Arg Gly
    370                 375                 380                 
Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys Phe Tyr Cys
385                 390                 395                 400 
Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp Val Lys Asp
                405                 410                 415     
Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys Ile Asp Ala
            420                 425                 430         
Phe Leu Lys Pro Pro Met Glu Thr Glu Glu Pro Gln Ile Phe Tyr Asn
        435                 440                 445             
Ala Ser Pro Ser Thr Leu Ser Ala Thr Met Phe Ile Val Ser Ile Leu
    450                 455                 460                 
Phe Leu Ile Ile Ser Ser Val Ala Ser Leu
465                 470                 


<210> 234
<211> 333
<212> PRT
<213> Homo sapiens

<220> 
<223> cathepsin L allelic variants

<220> 
<221> VARIANT        
<222> 56
<223> M or V

<220> 
<221> VARIANT        
<222> 268
<223> D or N

<400> 234
Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser
 1               5                  10                  15      
Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp
            20                  25                  30          
Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg
        35                  40                  45              
Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln
    50                  55                  60                  
Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe
65                  70                  75                  80  
Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln
                85                  90                  95      
Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr
            100                 105                 110         
Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro
        115                 120                 125             
Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr
    130                 135                 140                 
Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser
145                 150                 155                 160 
Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu
                165                 170                 175     
Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp
            180                 185                 190         
Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu
        195                 200                 205             
Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly
    210                 215                 220                 
Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala
225                 230                 235                 240 
Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe
                245                 250                 255     
Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu
            260                 265                 270         
Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr
        275                 280                 285             
Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu
    290                 295                 300                 
Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn
305                 310                 315                 320 

His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val
                325                 330             


<210> 235
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> 6 x His tag

<400> 235
His His His His His
 1               5  



<210> 236
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Flag Tag

<400> 236
Asp Tyr Lys Asp Asp Asp Asp Lys
 1               5              

<210> 237
<211> 450
<212> PRT
<213> Bos taurus

<220> 
<223> hyaluronidase

<400> 237
Met Arg Pro Phe Ser Leu Glu Val Ser Leu His Leu Pro Trp Ala Met
 1               5                  10                  15      
Ala Ala His Leu Leu Pro Val Cys Thr Leu Phe Leu Asn Leu Leu Ser
            20                  25                  30          
Met Thr Gln Gly Ser Arg Asp Pro Val Val Pro Asn Gln Pro Phe Thr
        35                  40                  45              
Thr Ile Trp Asn Ala Asn Thr Glu Trp Cys Met Lys Lys His Gly Val
    50                  55                  60                  
Asp Val Asp Ile Ser Ile Phe Asp Val Val Thr Asn Pro Gly Gln Thr
65                  70                  75                  80  
Phe Arg Gly Pro Asn Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly Thr
                85                  90                  95      
Tyr Pro Tyr Tyr Thr Ser Ala Gly Glu Pro Val Phe Gly Gly Leu Pro
            100                 105                 110         
Gln Asn Ala Ser Leu Asn Ala His Leu Ala Arg Thr Phe Gln Asp Ile
        115                 120                 125             
Leu Ala Ala Met Pro Glu Pro Arg Phe Ser Gly Leu Ala Val Ile Asp
    130                 135                 140                 
Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys Asp
145                 150                 155                 160 
Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Lys Gln His Pro Asp
                165                 170                 175     
Trp Leu Ala Pro Arg Val Glu Ala Ala Ala Gln Asp Gln Phe Glu Gly
            180                 185                 190         
Ala Ala Glu Glu Trp Met Ala Gly Thr Leu Lys Leu Gly Gln Ala Leu
        195                 200                 205             
Arg Pro Gln Gly Leu Trp Gly Phe Tyr Asn Phe Pro Glu Cys Tyr Asn
    210                 215                 220                 
Tyr Asp Phe Lys Ser Pro Asn Tyr Thr Gly Arg Cys Pro Leu Asn Ile
225                 230                 235                 240 
Cys Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg Ala
                245                 250                 255     
Leu Tyr Pro Ser Ile Tyr Leu Pro Ala Ala Leu Glu Gly Thr Lys Lys
            260                 265                 270         
Thr Gln Met Phe Val Gln His Arg Val Ala Glu Ala Phe Arg Val Ala
        275                 280                 285             
Ala Gly Ala Gly Asp Pro Lys Leu Pro Val Leu Pro Tyr Met Gln Leu
    290                 295                 300                 
Phe Tyr Asp Met Thr Asn His Phe Leu Pro Ala Glu Glu Leu Glu His
305                 310                 315                 320 
Ser Leu Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu Trp
                325                 330                 335     
Val Ser Trp Leu Ser Thr Ser Thr Lys Glu Ser Cys Gln Ala Ile Lys
            340                 345                 350         
Glu Tyr Val Asp Thr Thr Leu Gly Pro Ser Ile Leu Asn Val Thr Ser
        355                 360                 365             
Gly Ala Arg Leu Cys Ser Gln Val Leu Cys Ser Gly His Gly Arg Cys
    370                 375                 380                 
Ala Arg Arg Pro Ser Tyr Pro Lys Ala Arg Leu Ile Leu Asn Ser Thr
385                 390                 395                 400 
Ser Phe Ser Ile Lys Pro Thr Pro Gly Gly Gly Pro Leu Thr Leu Gln
                405                 410                 415     
Gly Ala Leu Ser Leu Glu Asp Arg Leu Arg Met Ala Val Glu Phe Glu
            420                 425                 430         
Cys Arg Cys Tyr Arg Gly Trp Arg Gly Thr Arg Cys Glu Gln Trp Gly
        435                 440                 445             
Met Trp
    450 


<210> 238
<211> 331
<212> PRT
<213> Vespula vulgaris

<220> 
<223> hyaluronidase A

<400> 238
Ser Glu Arg Pro Lys Arg Val Phe Asn Ile Tyr Trp Asn Val Pro Thr
 1               5                  10                  15      
Phe Met Cys His Gln Tyr Asp Leu Tyr Phe Asp Glu Val Thr Asn Phe
            20                  25                  30          
Asn Ile Lys Arg Asn Ser Lys Asp Asp Phe Gln Gly Asp Lys Ile Ala
        35                  40                  45              
Ile Phe Tyr Asp Pro Gly Glu Phe Pro Ala Leu Leu Ser Leu Lys Asp
    50                  55                  60                  
Gly Lys Tyr Lys Lys Arg Asn Gly Gly Val Pro Gln Glu Gly Asn Ile
65                  70                  75                  80  
Thr Ile His Leu Gln Lys Phe Ile Glu Asn Leu Asp Lys Ile Tyr Pro
                85                  90                  95      
Asn Arg Asn Phe Ser Gly Ile Gly Val Ile Asp Phe Glu Arg Trp Arg
            100                 105                 110         
Pro Ile Phe Arg Gln Asn Trp Gly Asn Met Lys Ile His Lys Asn Phe
        115                 120                 125             
Ser Ile Asp Leu Val Arg Asn Glu His Pro Thr Trp Asn Lys Lys Met
    130                 135                 140                 
Ile Glu Leu Glu Ala Ser Lys Arg Phe Glu Lys Tyr Ala Arg Phe Phe
145                 150                 155                 160 
Met Glu Glu Thr Leu Lys Leu Ala Lys Lys Thr Arg Lys Gln Ala Asp
                165                 170                 175     
Trp Gly Tyr Tyr Gly Tyr Pro Tyr Cys Phe Asn Met Ser Pro Asn Asn
            180                 185                 190         
Leu Val Pro Glu Cys Asp Val Thr Ala Met His Glu Asn Asp Lys Met
        195                 200                 205             
Ser Trp Leu Phe Asn Asn Gln Asn Val Leu Leu Pro Ser Val Tyr Val
    210                 215                 220                 
Arg Gln Glu Leu Thr Pro Asp Gln Arg Ile Gly Leu Val Gln Gly Arg
225                 230                 235                 240 
Val Lys Glu Ala Val Arg Ile Ser Asn Asn Leu Lys His Ser Pro Lys
                245                 250                 255     
Val Leu Ser Tyr Trp Trp Tyr Val Tyr Gln Asp Glu Thr Asn Thr Phe
            260                 265                 270         
Leu Thr Glu Thr Asp Val Lys Lys Thr Phe Gln Glu Ile Val Ile Asn
        275                 280                 285             
Gly Gly Asp Gly Ile Ile Ile Trp Gly Ser Ser Ser Asp Val Asn Ser
    290                 295                 300                 
Leu Ser Lys Cys Lys Arg Leu Gln Asp Tyr Leu Leu Thr Val Leu Gly
305                 310                 315                 320 
Pro Ile Ala Ile Asn Val Thr Glu Ala Val Asn
                325                 330     


<210> 239
<211> 340
<212> PRT
<213> Vespula vulgaris

<220> 
<223> hyaluronidase B

<400> 239
Asp Arg Thr Ile Trp Pro Lys Lys Gly Phe Ser Ile Tyr Trp Asn Ile
 1               5                  10                  15      
Pro Thr His Phe Cys His Asn Phe Gly Val Tyr Phe Lys Glu Leu Lys
            20                  25                  30          
Gln Phe Asn Ile Lys Tyr Asn Ser Met Asn Asn Phe Arg Gly Glu Thr
        35                  40                  45              
Ile Ser Leu Phe Tyr Asp Pro Gly Asn Phe Pro Ser Met Val Leu Leu
    50                  55                  60                  
Lys Asn Gly Thr Tyr Glu Ile Arg Asn Glu Gly Val Pro Gln Lys Gly
65                  70                  75                  80  
Asn Leu Thr Ile His Leu Glu Gln Phe Thr Lys Glu Leu Asp Glu Ile
                85                  90                  95      
Tyr Pro Lys Lys Ile Ala Gly Gly Ile Gly Val Ile His Phe His Asn
            100                 105                 110         
Trp Arg Pro Ile Phe Arg Arg Asn Val Asp Asn Leu Lys Ile Asn Lys
        115                 120                 125             
Asp Ile Ser Ile Asp Leu Val Arg Lys Glu His Pro Lys Trp Asp Lys
    130                 135                 140                 
Ser Met Ile Glu Lys Glu Ala Ser Asn Arg Phe Glu Thr Ser Ala Lys
145                 150                 155                 160 
Ile Phe Met Glu Lys Thr Leu Lys Leu Ala Lys Glu Ile Arg Lys Lys
                165                 170                 175     
Thr Glu Trp Gly Tyr His Gly Tyr Pro His Cys Leu Ser Gly Ser Thr
            180                 185                 190         
Asp Lys Pro Ser Phe Asp Cys Asp Ala Leu Ser Met Ser Glu Asn Asp
        195                 200                 205             
Lys Met Ser Trp Leu Phe Asn Asn Gln Asn Val Leu Leu Pro Ser Ile
    210                 215                 220                 
Tyr Leu Lys Asn Val Leu Lys Pro Asp Glu Lys Ile His Leu Val Gln
225                 230                 235                 240 
Glu Arg Leu Lys Glu Ala Ile Arg Ile Ser Lys Asn Phe Lys His Leu
                245                 250                 255     
Pro Lys Val Leu Pro Tyr Trp Trp Tyr Thr Tyr Gln Asp Lys Glu Ser
            260                 265                 270         
Ile Phe Leu Thr Glu Ala Asp Val Lys Asn Thr Phe Lys Glu Ile Leu
        275                 280                 285             
Thr Asn Gly Ala Asp Gly Ile Ile Ile Trp Gly Val Ser Tyr Glu Leu
    290                 295                 300                 
Thr Asp Arg Lys Arg Cys Glu Lys Leu Lys Glu Tyr Leu Met Lys Ile
305                 310                 315                 320 
Leu Gly Pro Ile Ala Phe Lys Val Thr Lys Ala Val Lys Glu Asn Thr
                325                 330                 335     
Pro Leu Asn Phe
            340 


<210> 240
<211> 382
<212> PRT
<213> Apis mellifera

<220> 
<223> hyaluronidase

<400> 240
Met Ser Arg Pro Leu Val Ile Thr Glu Gly Met Met Ile Gly Val Leu
 1               5                  10                  15      
Leu Met Leu Ala Pro Ile Asn Ala Leu Leu Leu Gly Phe Val Gln Ser
            20                  25                  30          
Thr Pro Asp Asn Asn Lys Thr Val Arg Glu Phe Asn Val Tyr Trp Asn
        35                  40                  45              
Val Pro Thr Phe Met Cys His Lys Tyr Gly Leu Arg Phe Glu Glu Val
    50                  55                  60                  
Ser Glu Lys Tyr Gly Ile Leu Gln Asn Trp Met Asp Lys Phe Arg Gly
65                  70                  75                  80  
Glu Glu Ile Ala Ile Leu Tyr Asp Pro Gly Met Phe Pro Ala Leu Leu
                85                  90                  95      
Lys Asp Pro Asn Gly Asn Val Val Ala Arg Asn Gly Gly Val Pro Gln
            100                 105                 110         
Leu Gly Asn Leu Thr Lys His Leu Gln Val Phe Arg Asp His Leu Ile
        115                 120                 125             
Asn Gln Ile Pro Asp Lys Ser Phe Pro Gly Val Gly Val Ile Asp Phe
    130                 135                 140                 
Glu Ser Trp Arg Pro Ile Phe Arg Gln Asn Trp Ala Ser Leu Gln Pro

145                 150                 155                 160 
Tyr Lys Lys Leu Ser Val Glu Val Val Arg Arg Glu His Pro Phe Trp
                165                 170                 175     
Asp Asp Gln Arg Val Glu Gln Glu Ala Lys Arg Arg Phe Glu Lys Tyr
            180                 185                 190         
Gly Gln Leu Phe Met Glu Glu Thr Leu Lys Ala Ala Lys Arg Met Arg
        195                 200                 205             
Pro Ala Ala Asn Trp Gly Tyr Tyr Ala Tyr Pro Tyr Cys Tyr Asn Leu
    210                 215                 220                 
Thr Pro Asn Gln Pro Ser Ala Gln Cys Glu Ala Thr Thr Met Gln Glu
225                 230                 235                 240 
Asn Asp Lys Met Ser Trp Leu Phe Glu Ser Glu Asp Val Leu Leu Pro
                245                 250                 255     
Ser Val Tyr Leu Arg Trp Asn Leu Thr Ser Gly Glu Arg Val Gly Leu
            260                 265                 270         
Val Gly Gly Arg Val Lys Glu Ala Leu Arg Ile Ala Arg Gln Met Thr
        275                 280                 285             
Thr Ser Arg Lys Lys Val Leu Pro Tyr Tyr Trp Tyr Lys Tyr Gln Asp
    290                 295                 300                 
Arg Arg Asp Thr Asp Leu Ser Arg Ala Asp Leu Glu Ala Thr Leu Arg
305                 310                 315                 320 
Lys Ile Thr Asp Leu Gly Ala Asp Gly Phe Ile Ile Trp Gly Ser Ser
                325                 330                 335     
Asp Asp Ile Asn Thr Lys Ala Lys Cys Leu Gln Phe Arg Glu Tyr Leu
            340                 345                 350         
Asn Asn Glu Leu Gly Pro Ala Val Lys Arg Ile Ala Leu Asn Asn Asn
        355                 360                 365             
Ala Asn Asp Arg Leu Thr Val Asp Val Ser Val Asp Gln Val
    370                 375                 380         


<210> 241
<211> 331
<212> PRT
<213> Dolichovespula maculata

<220> 
<223> hyaluronidase

<400> 241
Ser Glu Arg Pro Lys Arg Val Phe Asn Ile Tyr Trp Asn Val Pro Thr
 1               5                  10                  15      
Phe Met Cys His Gln Tyr Gly Leu Tyr Phe Asp Glu Val Thr Asn Phe
            20                  25                  30          
Asn Ile Lys His Asn Ser Lys Asp Asp Phe Gln Gly Asp Lys Ile Ser
        35                  40                  45              
Ile Phe Tyr Asp Pro Gly Glu Phe Pro Ala Leu Leu Pro Leu Lys Glu
    50                  55                  60                  
Gly Asn Tyr Lys Ile Arg Asn Gly Gly Val Pro Gln Glu Gly Asn Ile
65                  70                  75                  80  
Thr Ile His Leu Gln Arg Phe Ile Glu Asn Leu Asp Lys Thr Tyr Pro
                85                  90                  95      
Asn Arg Asn Phe Asn Gly Ile Gly Val Ile Asp Phe Glu Arg Trp Arg
            100                 105                 110         
Pro Ile Phe Arg Gln Asn Trp Gly Asn Met Met Ile His Lys Lys Phe
        115                 120                 125             
Ser Ile Asp Leu Val Arg Asn Glu His Pro Phe Trp Asp Lys Lys Met
    130                 135                 140                 
Ile Glu Leu Glu Ala Ser Lys Arg Phe Glu Lys Tyr Ala Arg Leu Phe
145                 150                 155                 160 
Met Glu Glu Thr Leu Lys Leu Ala Lys Lys Thr Arg Lys Gln Ala Asp
                165                 170                 175     
Trp Gly Tyr Tyr Gly Tyr Pro Tyr Cys Phe Asn Met Ser Pro Asn Asn
            180                 185                 190         
Leu Val Pro Asp Cys Asp Ala Thr Ala Met Leu Glu Asn Asp Lys Met
        195                 200                 205             
Ser Trp Leu Phe Asn Asn Gln Asn Val Leu Leu Pro Ser Val Tyr Ile
    210                 215                 220                 
Arg His Glu Leu Thr Pro Asp Gln Arg Val Gly Leu Val Gln Gly Arg
225                 230                 235                 240 
Val Lys Glu Ala Val Arg Ile Ser Asn Asn Leu Lys His Ser Pro Lys
                245                 250                 255     
Val Leu Ser Tyr Trp Trp Tyr Val Tyr Gln Asp Asp Thr Asn Thr Phe
            260                 265                 270         
Leu Thr Glu Thr Asp Val Lys Lys Thr Phe Gln Glu Ile Ala Ile Asn
        275                 280                 285             
Gly Gly Asp Gly Ile Ile Ile Trp Gly Ser Ser Ser Asp Val Asn Ser
    290                 295                 300                 
Leu Ser Lys Cys Lys Arg Leu Arg Glu Tyr Leu Leu Thr Val Leu Gly
305                 310                 315                 320 
Pro Ile Thr Val Asn Val Thr Glu Thr Val Asn
                325                 330     


<210> 242
<211> 367
<212> PRT
<213> Polistes annularis

<220> 
<223> hyaluronidase

<400> 242
Tyr Val Ser Leu Ser Pro Asp Ser Val Phe Asn Ile Ile Thr Asp Asp
 1               5                  10                  15      
Ile Ser His Gln Ile Leu Ser Arg Ser Asn Cys Glu Arg Ser Lys Arg
            20                  25                  30          
Pro Lys Arg Val Phe Ser Ile Tyr Trp Asn Val Pro Thr Phe Met Cys
        35                  40                  45              
His Gln Tyr Gly Met Asn Phe Asp Glu Val Thr Asp Phe Asn Ile Lys
    50                  55                  60                  
His Asn Ser Lys Asp Asn Phe Arg Gly Glu Thr Ile Ser Ile Tyr Tyr
65                  70                  75                  80  
Asp Pro Gly Lys Phe Pro Ala Leu Met Pro Leu Lys Asn Gly Asn Tyr
                85                  90                  95      
Glu Glu Arg Asn Gly Gly Val Pro Gln Arg Gly Asn Ile Thr Ile His
            100                 105                 110         
Leu Gln Gln Phe Asn Glu Asp Leu Asp Lys Met Thr Pro Asp Lys Asn
        115                 120                 125             
Phe Gly Gly Ile Gly Val Ile Asp Phe Glu Arg Trp Lys Pro Ile Phe
    130                 135                 140                 
Arg Gln Asn Trp Gly Asn Thr Glu Ile His Lys Lys Tyr Ser Ile Glu
145                 150                 155                 160 
Leu Val Arg Lys Glu His Pro Lys Trp Ser Glu Ser Met Ile Glu Ala
                165                 170                 175     
Glu Ala Thr Lys Lys Phe Glu Lys Tyr Ala Arg Tyr Phe Met Glu Glu
            180                 185                 190         
Thr Leu Lys Leu Ala Lys Lys Thr Arg Lys Arg Ala Lys Trp Gly Tyr
        195                 200                 205             
Tyr Gly Phe Pro Tyr Cys Tyr Asn Val Thr Pro Asn Asn Pro Gly Pro
    210                 215                 220                 
Asp Cys Asp Ala Lys Ala Thr Ile Glu Asn Asp Arg Leu Ser Trp Met
225                 230                 235                 240 
Tyr Asn Asn Gln Glu Ile Leu Phe Pro Ser Val Tyr Val Arg His Glu
                245                 250                 255     
Gln Lys Pro Glu Glu Arg Val Tyr Leu Val Gln Gly Arg Ile Lys Glu
            260                 265                 270         
Ala Val Arg Ile Ser Asn Asn Leu Glu His Ser Pro Ser Val Leu Ala
        275                 280                 285             
Tyr Trp Trp Tyr Val Tyr Gln Asp Lys Met Asp Ile Tyr Leu Ser Glu
    290                 295                 300                 
Thr Asp Val Glu Lys Thr Phe Gln Glu Ile Val Thr Asn Gly Gly Asp
305                 310                 315                 320 
Gly Ile Ile Ile Trp Gly Ser Ser Ser Asp Val Asn Ser Leu Ser Lys
                325                 330                 335     
Cys Lys Arg Leu Arg Glu Tyr Leu Leu Asn Thr Leu Gly Pro Phe Ala
            340                 345                 350         
Val Asn Val Thr Glu Thr Val Asn Gly Arg Ser Ser Leu Asn Phe
        355                 360                 365         


<210> 243
<211> 462
<212> PRT
<213> Mus musculus

<220> 
<223> hyaluronidase

<400> 243
Met Leu Gly Leu Thr Gln His Ala Gln Lys Val Trp Arg Met Lys Pro
 1               5                  10                  15      
Phe Ser Pro Glu Val Ser Pro Gly Ser Ser Pro Ala Thr Ala Gly His
            20                  25                  30          
Leu Leu Arg Ile Ser Thr Leu Phe Leu Thr Leu Leu Glu Leu Ala Gln
        35                  40                  45              
Val Cys Arg Gly Ser Val Val Ser Asn Arg Pro Phe Ile Thr Val Trp
    50                  55                  60                  
Asn Gly Asp Thr His Trp Cys Leu Thr Glu Tyr Gly Val Asp Val Asp
65                  70                  75                  80  
Val Ser Val Phe Asp Val Val Ala Asn Lys Glu Gln Ser Phe Gln Gly
                85                  90                  95      
Ser Asn Met Thr Ile Phe Tyr Arg Glu Glu Leu Gly Thr Tyr Pro Tyr
            100                 105                 110         
Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu Pro Gln Asn Ala
        115                 120                 125             
Ser Leu Val Thr His Leu Ala His Thr Phe Gln Asp Ile Lys Ala Ala
    130                 135                 140                 
Met Pro Glu Pro Asp Phe Ser Gly Leu Ala Val Ile Asp Trp Glu Ala
145                 150                 155                 160 
Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Ser Lys Asp Ile Tyr Arg
                165                 170                 175     
Gln Arg Ser Met Glu Leu Val Gln Ala Glu His Pro Asp Trp Pro Glu
            180                 185                 190         
Thr Leu Val Glu Ala Ala Ala Lys Asn Gln Phe Gln Glu Ala Ala Glu
        195                 200                 205             
Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Gln Val Leu Arg Pro Arg
    210                 215                 220                 
Gly Leu Trp Gly Tyr Tyr Gly Phe Pro Asp Cys Tyr Asn Asn Asp Phe
225                 230                 235                 240 
Leu Ser Leu Asn Tyr Thr Gly Gln Cys Pro Val Phe Val Arg Asp Gln
                245                 250                 255     
Asn Asp Gln Leu Gly Trp Leu Trp Asn Gln Ser Tyr Ala Leu Tyr Pro
            260                 265                 270         
Ser Ile Tyr Leu Pro Ala Ala Leu Met Gly Thr Gly Lys Ser Gln Met
        275                 280                 285             
Tyr Val Arg His Arg Val Gln Glu Ala Leu Arg Val Ala Ile Val Ser
    290                 295                 300                 
Arg Asp Pro His Val Pro Val Met Pro Tyr Val Gln Ile Phe Tyr Glu
305                 310                 315                 320 
Met Thr Asp Tyr Leu Leu Pro Leu Glu Glu Leu Glu His Ser Leu Gly
                325                 330                 335     
Glu Ser Ala Ala Gln Gly Val Ala Gly Ala Val Leu Trp Leu Ser Ser
            340                 345                 350         
Asp Lys Thr Ser Thr Lys Glu Ser Cys Gln Ala Ile Lys Ala Tyr Met
        355                 360                 365             
Asp Ser Thr Leu Gly Pro Phe Ile Val Asn Val Thr Ser Ala Ala Leu
    370                 375                 380                 
Leu Cys Ser Glu Ala Leu Cys Ser Gly His Gly Arg Cys Val Arg His
385                 390                 395                 400 
Pro Ser Tyr Pro Glu Ala Leu Leu Thr Leu Asn Pro Ala Ser Phe Ser
                405                 410                 415     
Ile Glu Leu Thr His Asp Gly Arg Pro Pro Ser Leu Lys Gly Thr Leu
            420                 425                 430         
Ser Leu Lys Asp Arg Ala Gln Met Ala Met Lys Phe Arg Cys Arg Cys
        435                 440                 445             
Tyr Arg Gly Trp Arg Gly Lys Trp Cys Asp Lys Arg Gly Met
    450                 455                 460         


<210> 244
<211> 473
<212> PRT
<213> Mus musculus

<220> 
<223> Hyaluronidase 2

<400> 244
Met Arg Ala Gly Leu Gly Pro Ile Ile Thr Leu Ala Leu Val Leu Glu
 1               5                  10                  15      
Val Ala Trp Ala Gly Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr
            20                  25                  30          
Gly Arg Pro Phe Val Val Ala Trp Asn Val Pro Thr Gln Glu Cys Ala
        35                  40                  45              
Pro Arg His Lys Val Pro Leu Asp Leu Arg Ala Phe Asp Val Lys Ala
    50                  55                  60                  
Thr Pro Asn Glu Gly Phe Phe Asn Gln Asn Ile Thr Thr Phe Tyr Tyr
65                  70                  75                  80  
Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ala Ala Gly Thr Ser Val
                85                  90                  95      
His Gly Gly Val Pro Gln Asn Gly Ser Leu Cys Ala His Leu Pro Met
            100                 105                 110         
Leu Lys Glu Ser Val Glu Arg Tyr Ile Gln Thr Gln Glu Pro Gly Gly
        115                 120                 125             
Leu Ala Val Ile Asp Trp Glu Glu Trp Arg Pro Val Trp Val Arg Asn
    130                 135                 140                 
Trp Gln Glu Lys Asp Val Tyr Arg Gln Ser Ser Arg Gln Leu Val Ala
145                 150                 155                 160 
Ser Arg His Pro Asp Trp Pro Ser Asp Arg Val Met Lys Gln Ala Gln
                165                 170                 175     
Tyr Glu Phe Glu Phe Ala Ala Arg Gln Phe Met Leu Asn Thr Leu Arg

            180                 185                 190         
Tyr Val Lys Ala Val Arg Pro Gln His Leu Trp Gly Phe Tyr Leu Phe
        195                 200                 205             
Pro Asp Cys Tyr Asn His Asp Tyr Val Gln Asn Trp Glu Ser Tyr Thr
    210                 215                 220                 
Gly Arg Cys Pro Asp Val Glu Val Ala Arg Asn Asp Gln Leu Ala Trp
225                 230                 235                 240 
Leu Trp Ala Glu Ser Thr Ala Leu Phe Pro Ser Val Tyr Leu Asp Glu
                245                 250                 255     
Thr Leu Ala Ser Ser Val His Ser Arg Asn Phe Val Ser Phe Arg Val
            260                 265                 270         
Arg Glu Ala Leu Arg Val Ala His Thr His His Ala Asn His Ala Leu
        275                 280                 285             
Pro Val Tyr Val Phe Thr Arg Pro Thr Tyr Thr Arg Gly Leu Thr Gly
    290                 295                 300                 
Leu Ser Gln Val Asp Leu Ile Ser Thr Ile Gly Glu Ser Ala Ala Leu
305                 310                 315                 320 
Gly Ser Ala Gly Val Ile Phe Trp Gly Asp Ser Glu Asp Ala Ser Ser
                325                 330                 335     
Met Glu Thr Cys Gln Tyr Leu Lys Asn Tyr Leu Thr Gln Leu Leu Val
            340                 345                 350         
Pro Tyr Ile Val Asn Val Ser Trp Ala Thr Gln Tyr Cys Ser Trp Thr
        355                 360                 365             
Gln Cys His Gly His Gly Arg Cys Val Arg Arg Asn Pro Ser Ala Asn
    370                 375                 380                 
Thr Phe Leu His Leu Asn Ala Ser Ser Phe Arg Leu Val Pro Gly His
385                 390                 395                 400 
Thr Pro Ser Glu Pro Gln Leu Arg Pro Glu Gly Gln Leu Ser Glu Ala
                405                 410                 415     
Asp Leu Asn Tyr Leu Gln Lys His Phe Arg Cys Gln Cys Tyr Leu Gly
            420                 425                 430         
Trp Gly Gly Glu Gln Cys Gln Arg Asn Tyr Lys Gly Ala Ala Gly Asn
        435                 440                 445             
Ala Ser Arg Ala Trp Ala Gly Ser His Leu Thr Ser Leu Leu Gly Leu
    450                 455                 460                 
Val Ala Val Ala Leu Thr Trp Thr Leu
465                 470             


<210> 245
<211> 412
<212> PRT
<213> Mus musculus

<220> 
<223> hyalurinidase 3

<400> 245
Met Ile Met His Leu Gly Leu Met Met Val Val Gly Leu Thr Leu Cys
 1               5                  10                  15      
Leu Met His Gly Gln Ala Leu Leu Gln Val Pro Glu His Pro Phe Ser
            20                  25                  30          
Val Val Trp Asn Val Pro Ser Ala Arg Cys Lys Ala His Phe Gly Val
        35                  40                  45              
His Leu Pro Leu Asp Ala Leu Gly Ile Val Ala Asn His Gly Gln His
    50                  55                  60                  
Phe His Gly Gln Asn Ile Ser Ile Phe Tyr Lys Asn Gln Phe Gly Leu
65                  70                  75                  80  
Tyr Pro Tyr Phe Gly Pro Arg Gly Thr Ala His Asn Gly Gly Ile Pro
                85                  90                  95      
Gln Ala Val Ser Leu Asp His His Leu Ala Arg Ala Ala His Gln Ile
            100                 105                 110         
Leu His Ser Leu Gly Ser Ser Phe Ala Gly Leu Ala Val Leu Asp Trp
        115                 120                 125             
Glu Glu Trp Tyr Pro Leu Trp Ala Gly Asn Trp Gly Pro His Arg Gln

    130                 135                 140                 
Val Tyr Leu Ala Ala Ser Trp Val Trp Thr Gln Gln Met Phe Pro Gly
145                 150                 155                 160 
Leu Asp Pro Gln Glu Gln Leu His Lys Ala His Thr Ser Phe Glu Gln
                165                 170                 175     
Ala Ala Arg Ala Leu Met Glu Tyr Thr Leu Gln Leu Gly Arg Thr Leu
            180                 185                 190         
Arg Pro Ser Gly Leu Trp Gly Phe Tyr Arg Tyr Pro Ala Cys Gly Asn
        195                 200                 205             
Gly Trp His Lys Met Ala Ser Asn Tyr Thr Gly His Cys His Ala Ala
    210                 215                 220                 
Ile Thr Thr Gln Asn Thr Gln Leu Arg Trp Leu Trp Ala Ala Ser Ser
225                 230                 235                 240 
Ala Leu Phe Pro Ser Ile Tyr Leu Pro Pro Arg Leu Pro Leu Ala Tyr
                245                 250                 255     
Arg Gln Ala Phe Val Arg His Arg Leu Glu Glu Ala Phe Arg Val Ala
            260                 265                 270         
Leu Leu Glu His Ser His Pro Leu Pro Val Leu Ala Tyr Ser Arg Leu
        275                 280                 285             
Thr His Arg Ser Ser Gly Arg Phe Leu Ser Leu Asp Asp Leu Met Gln
    290                 295                 300                 
Thr Ile Gly Val Ser Ala Ala Leu Gly Thr Ala Gly Val Val Leu Trp
305                 310                 315                 320 
Gly Asp Leu Ser Phe Ser Ser Ser Glu Glu Lys Cys Trp Arg Leu His
                325                 330                 335     
Asp Tyr Leu Val Gly Thr Leu Gly Pro Tyr Val Ile Asn Val Thr Lys
            340                 345                 350         
Ala Asp Met Ala Cys Ser His Gln Arg Cys His Gly His Gly Arg Cys
        355                 360                 365             
Ala Arg Lys Asp Pro Gly Gln Met Glu Ala Phe Leu His Leu Gln Pro
    370                 375                 380                 
Asp Asp Ser Leu Gly Ala Trp Asn Ser Phe Arg Cys His Cys Tyr Ser
385                 390                 395                 400 
Gly Trp Ala Gly Pro Thr Cys Leu Glu Pro Lys Pro
                405                 410         


<210> 246
<211> 435
<212> PRT
<213> Sus scrofa

<220> 
<223> hyalauronidase

<400> 246
Met Ala Ala His Leu Leu Pro Ile Cys Thr Leu Phe Leu Asn Leu Leu
 1               5                  10                  15      
Ser Val Ala Gln Gly Ser Arg Asp Pro Val Val Leu Asn Arg Pro Phe
            20                  25                  30          
Thr Thr Ile Trp Asn Ala Asn Thr Gln Trp Cys Leu Lys Arg His Gly
        35                  40                  45              
Val Asp Val Asp Val Ser Val Phe Glu Val Val Val Asn Pro Gly Gln
    50                  55                  60                  
Thr Phe Arg Gly Pro Asn Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly
65                  70                  75                  80  
Thr Tyr Pro Tyr Tyr Thr Ser Ala Gly Glu Pro Val Phe Gly Gly Leu
                85                  90                  95      
Pro Gln Asn Ala Ser Leu Asp Val His Leu Asn Arg Thr Phe Lys Asp
            100                 105                 110         
Ile Leu Ala Ala Met Pro Glu Ser Asn Phe Ser Gly Leu Ala Val Ile
        115                 120                 125             
Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Ala Lys
    130                 135                 140                 
Asp Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Lys Gln His Pro
145                 150                 155                 160 
Asp Trp Pro Ala Pro Trp Val Glu Ala Ala Ala Gln Asp Gln Phe Gln
                165                 170                 175     
Glu Ala Ala Gln Thr Trp Met Ala Gly Thr Leu Lys Leu Gly Gln Thr
            180                 185                 190         
Leu Arg Pro His Gly Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr
        195                 200                 205             
Asn Tyr Asp Phe Gln Ser Ser Asn Tyr Thr Gly Gln Cys Pro Pro Gly
    210                 215                 220                 
Val Ser Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg
225                 230                 235                 240 
Ala Leu Tyr Pro Ser Ile Tyr Leu Pro Ser Ala Leu Glu Gly Thr Asn
                245                 250                 255     
Lys Thr Gln Leu Tyr Val Gln His Arg Val Asn Glu Ala Phe Arg Val
            260                 265                 270         
Ala Ala Ala Ala Gly Asp Pro Asn Leu Pro Val Leu Pro Tyr Ala Gln
        275                 280                 285             
Ile Phe His Asp Met Thr Asn Arg Leu Leu Ser Arg Glu Glu Leu Glu
    290                 295                 300                 
His Ser Leu Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu
305                 310                 315                 320 
Trp Val Ser Trp Glu Asn Thr Arg Thr Lys Glu Ser Cys Gln Ser Ile
                325                 330                 335     
Lys Glu Tyr Val Asp Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr
            340                 345                 350         
Ser Gly Ala Leu Leu Cys Ser Gln Ala Val Cys Ser Gly His Gly Arg
        355                 360                 365             
Cys Val Arg Arg Pro Ser His Thr Glu Ala Leu Pro Ile Leu Asn Pro
    370                 375                 380                 
Ser Ser Phe Ser Ile Lys Pro Thr Pro Gly Gly Gly Pro Leu Thr Leu
385                 390                 395                 400 
Gln Gly Ala Leu Ser Leu Lys Asp Arg Val Gln Met Ala Glu Glu Phe
                405                 410                 415     
Gln Cys Arg Cys Tyr Pro Gly Trp Arg Gly Thr Trp Cys Glu Gln Gln
            420                 425                 430         
Gly Thr Arg
        435 


<210> 247
<211> 419
<212> PRT
<213> Sus scrofa

<220> 
<223> hyaluronidase 3

<400> 247
Met Thr Met Gln Leu Gly Leu Ala Leu Val Leu Gly Val Ala Met Cys
 1               5                  10                  15      
Leu Gly Cys Gly Gln Pro Leu Leu Arg Ala Pro Glu Arg Pro Phe Cys
            20                  25                  30          
Val Leu Trp Asn Val Pro Ser Ala Arg Cys Lys Ala Arg Phe Gly Val
        35                  40                  45              
His Leu Pro Leu Glu Ala Leu Gly Ile Thr Ala Asn His Gly Gln Arg
    50                  55                  60                  
Phe His Gly Gln Asn Ile Thr Ile Phe Tyr Lys Ser Gln Leu Gly Leu
65                  70                  75                  80  
Tyr Pro Tyr Phe Gly Pro Arg Gly Thr Ala His Asn Gly Gly Ile Pro
                85                  90                  95      
Gln Ala Val Ser Leu Asp His His Leu Ala Arg Ala Ala Tyr Gln Ile
            100                 105                 110         
His Arg Ser Leu Arg Pro Gly Phe Thr Gly Leu Ala Val Leu Asp Trp
        115                 120                 125             
Glu Glu Trp Cys Pro Leu Trp Ala Gly Asn Trp Gly Arg Arg Gln Ala
    130                 135                 140                 
Tyr Gln Ala Ala Ser Cys Ala Trp Ala Gln Arg Val Tyr Pro Asn Leu
145                 150                 155                 160 
Asp Pro Gln Glu Gln Leu Cys Lys Ala Arg Ala Gly Phe Glu Glu Ala
                165                 170                 175     
Ala Arg Ala Leu Met Glu Asp Thr Leu Arg Leu Gly Arg Met Leu Arg
            180                 185                 190         
Pro His Gly Leu Trp Gly Phe Tyr His Tyr Pro Ala Cys Gly Asn Gly
        195                 200                 205             
Trp His Gly Thr Ala Ser Asn Tyr Thr Gly His Cys His Ala Ala Ala
    210                 215                 220                 
Leu Ala Arg Asn Thr Gln Leu Tyr Trp Leu Trp Ala Ala Ser Ser Ala
225                 230                 235                 240 
Leu Phe Pro Ser Ile Tyr Leu Pro Pro Gly Leu Pro Pro Ala Tyr His
                245                 250                 255     
Gln Ala Phe Val Arg Tyr Arg Leu Glu Glu Ala Phe Arg Val Ala Leu
            260                 265                 270         
Val Gly His Pro His Pro Leu Pro Val Leu Ala Tyr Ala Arg Leu Thr
        275                 280                 285             
His Arg Asn Ser Gly Arg Phe Leu Ser Gln Asp Glu Leu Val Gln Thr
    290                 295                 300                 
Ile Gly Val Ser Ala Ala Leu Gly Ala Ser Gly Val Val Leu Trp Gly
305                 310                 315                 320 
Asp Leu Ser Phe Ser Ser Ser Glu Glu Glu Cys Trp His Leu Arg Gly
                325                 330                 335     
Tyr Leu Val Gly Thr Leu Gly Pro Tyr Val Ile Asn Val Thr Arg Ala
            340                 345                 350         
Ala Met Ala Cys Ser His Gln Arg Cys His Gly His Gly Arg Cys Ala
        355                 360                 365             
Trp Gln Asp Pro Gly Gln Leu Lys Val Phe Leu His Leu His Pro Gly
    370                 375                 380                 
Gly Ser Pro Gly Ala Trp Glu Ser Phe Ser Cys Arg Cys Tyr Trp Gly
385                 390                 395                 400 
Trp Ala Gly Pro Thr Cys Gln Glu Pro Arg Pro Glu Leu Gly Pro Glu
                405                 410                 415     
Glu Ala Thr
            


<210> 248
<211> 449
<212> PRT
<213> Rattus norvegicus

<220> 
<223> hyaluronidase 1

<400> 248
Met Lys Pro Phe Ser Pro Glu Val Ser Pro Asp Pro Cys Pro Ala Thr
 1               5                  10                  15      
Ala Ala His Leu Leu Arg Thr Tyr Thr Leu Phe Leu Thr Leu Leu Glu
            20                  25                  30          
Leu Ala Gln Gly Cys Arg Gly Ser Met Val Ser Asn Arg Pro Phe Ile
        35                  40                  45              
Thr Val Trp Asn Ala Asp Thr His Trp Cys Leu Lys Asp His Gly Val
    50                  55                  60                  
Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Lys Glu Gln Asn
65                  70                  75                  80  
Phe Gln Gly Pro Asn Met Thr Ile Phe Tyr Arg Glu Glu Leu Gly Thr
                85                  90                  95      
Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu Pro
            100                 105                 110         
Gln Asn Ala Ser Leu Val Thr His Leu Ala His Ala Phe Gln Asp Ile
        115                 120                 125             
Lys Ala Ala Met Pro Glu Pro Asp Phe Ser Gly Leu Ala Val Ile Asp
    130                 135                 140                 
Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Ser Lys Asp
145                 150                 155                 160 
Ile Tyr Gln Gln Arg Ser Met Glu Leu Val Arg Ala Glu His Pro Asp
                165                 170                 175     

Trp Pro Glu Thr Leu Val Glu Ala Glu Ala Gln Gly Gln Phe Gln Glu
            180                 185                 190         
Ala Ala Glu Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Gln Val Leu
        195                 200                 205             
Arg Pro Arg Gly Leu Trp Gly Tyr Tyr Gly Phe Pro Asp Cys Tyr Asn
    210                 215                 220                 
Tyr Asp Phe Leu Ser Pro Asn Tyr Thr Gly Gln Cys Ser Leu Ser Ile
225                 230                 235                 240 
His Asp Gln Asn Asp Gln Leu Gly Trp Leu Trp Asn Gln Ser Tyr Ala
                245                 250                 255     
Leu Tyr Pro Ser Ile Tyr Leu Pro Ala Ala Leu Met Gly Thr Gly Lys
            260                 265                 270         
Ser Gln Met Tyr Val Arg Tyr Arg Val Gln Glu Ala Phe Arg Leu Ala
        275                 280                 285             
Leu Val Ser Arg Asp Pro His Val Pro Ile Met Pro Tyr Val Gln Ile
    290                 295                 300                 
Phe Tyr Glu Lys Thr Asp Tyr Leu Leu Pro Leu Glu Glu Leu Glu His
305                 310                 315                 320 
Ser Leu Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Ala Val Leu Trp
                325                 330                 335     
Ile Ser Ser Glu Lys Thr Ser Thr Lys Glu Ser Cys Gln Ala Ile Lys
            340                 345                 350         
Ala Tyr Met Asp Ser Thr Leu Gly Pro Phe Ile Leu Asn Val Thr Ser
        355                 360                 365             
Ala Ala Leu Leu Cys Ser Glu Ala Leu Cys Ser Gly Arg Gly Arg Cys
    370                 375                 380                 
Val Arg His Pro Ser Tyr Pro Glu Ala Leu Leu Thr Leu Ser Pro Ala
385                 390                 395                 400 
Ser Phe Ser Ile Glu Pro Thr His Asp Gly Arg Pro Leu Ser Leu Lys
                405                 410                 415     
Gly Thr Leu Ser Leu Lys Asp Arg Ala Gln Met Ala Met Lys Phe Lys
            420                 425                 430         
Cys Arg Cys Tyr Arg Gly Trp Ser Gly Glu Trp Cys Lys Lys Gln Asp
        435                 440                 445             
Met
    


<210> 249
<211> 473
<212> PRT
<213> Rattus norvegicus

<220> 
<223> hyaluronidase 2

<400> 249
Met Arg Ala Gly Leu Gly Pro Ile Ile Thr Leu Ala Leu Val Leu Glu
 1               5                  10                  15      
Val Ala Trp Ala Ser Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr
            20                  25                  30          
Gly Arg Pro Phe Val Val Ala Trp Asn Val Pro Thr Gln Glu Cys Ala
        35                  40                  45              
Pro Arg His Lys Val Pro Leu Asp Leu Arg Ala Phe Asp Val Glu Ala
    50                  55                  60                  
Thr Pro Asn Glu Gly Phe Phe Asn Gln Asn Ile Thr Thr Phe Tyr Tyr
65                  70                  75                  80  
Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ala Ala Gly Met Ser Val
                85                  90                  95      
His Gly Gly Val Pro Gln Asn Gly Ser Leu Cys Ala His Leu Pro Met
            100                 105                 110         
Leu Lys Glu Ala Val Glu Arg Tyr Ile Gln Thr Gln Glu Pro Ala Gly

        115                 120                 125             
Leu Ala Val Ile Asp Trp Glu Glu Trp Arg Pro Val Trp Val Arg Asn
    130                 135                 140                 
Trp Gln Glu Lys Asp Val Tyr Arg Gln Ser Ser Arg Gln Leu Val Ala
145                 150                 155                 160 
Ser Arg His Pro Asp Trp Pro Ser Asp Arg Ile Val Lys Gln Ala Gln
                165                 170                 175     
Tyr Glu Phe Glu Phe Ala Ala Arg Gln Phe Met Leu Asn Thr Leu Arg
            180                 185                 190         
Tyr Val Lys Ala Val Arg Pro Gln His Leu Trp Gly Phe Tyr Leu Phe
        195                 200                 205             
Pro Asp Cys Tyr Asn His Asp Tyr Val Gln Asn Trp Asp Ser Tyr Thr
    210                 215                 220                 
Gly Arg Cys Pro Asp Val Glu Val Ala Gln Asn Asp Gln Leu Ala Trp
225                 230                 235                 240 
Leu Trp Ala Glu Asn Thr Ala Leu Phe Pro Ser Val Tyr Leu Asp Lys
                245                 250                 255     
Thr Leu Ala Ser Ser Lys His Ser Arg Asn Phe Val Ser Phe Arg Val
            260                 265                 270         
Gln Glu Ala Leu Arg Val Ala His Thr His His Ala Asn His Ala Leu
        275                 280                 285             
Pro Val Tyr Val Phe Thr Arg Pro Thr Tyr Thr Arg Arg Leu Thr Glu
    290                 295                 300                 
Leu Asn Gln Met Asp Leu Ile Ser Thr Ile Gly Glu Ser Ala Ala Leu
305                 310                 315                 320 
Gly Ser Ala Gly Val Ile Phe Trp Gly Asp Ser Val Tyr Ala Ser Ser
                325                 330                 335     
Met Glu Asn Cys Gln Asn Leu Lys Lys Tyr Leu Thr Gln Thr Leu Val
            340                 345                 350         
Pro Tyr Ile Val Asn Val Ser Trp Ala Thr Gln Tyr Cys Ser Trp Thr
        355                 360                 365             
Gln Cys His Gly His Gly Arg Cys Val Arg Arg Asn Pro Ser Ala Ser
    370                 375                 380                 
Thr Phe Leu His Leu Ser Pro Ser Ser Phe Arg Leu Val Pro Gly Arg
385                 390                 395                 400 
Thr Pro Ser Glu Pro Gln Leu Arg Pro Glu Gly Glu Leu Ser Glu Asp
                405                 410                 415     
Asp Leu Ser Tyr Leu Gln Met His Phe Arg Cys His Cys Tyr Leu Gly
            420                 425                 430         
Trp Gly Gly Glu Gln Cys Gln Trp Asn His Lys Arg Ala Ala Gly Asp
        435                 440                 445             
Ala Ser Arg Ala Trp Ala Gly Ala His Leu Ala Ser Leu Leu Gly Leu
    450                 455                 460                 
Val Ala Met Thr Leu Thr Trp Thr Leu
465                 470             


<210> 250
<211> 412
<212> PRT
<213> Rattus norvegicus

<220> 
<223> hyaluronidase 3

<400> 250
Met Ile Thr Gln Leu Gly Leu Thr Leu Val Val Gly Leu Thr Leu Cys
 1               5                  10                  15      
Leu Val His Val Gln Ala Leu Leu Gln Val Pro Glu Phe Pro Phe Ser
            20                  25                  30          
Val Leu Trp Asn Val Pro Ser Ala Arg Cys Lys Thr Arg Phe Gly Val
        35                  40                  45              
His Leu Pro Leu Asp Ala Leu Gly Ile Ile Ala Asn His Gly Gln Arg
    50                  55                  60                  
Phe His Gly Gln Asn Ile Thr Ile Phe Tyr Lys Asn Gln Phe Gly Leu
65                  70                  75                  80  
Tyr Pro Tyr Phe Gly Pro Arg Gly Thr Ala His Asn Gly Gly Ile Pro
                85                  90                  95      
Gln Ala Val Ser Leu Asp His His Leu Ala Gln Ala Ala His Gln Ile
            100                 105                 110         
Leu His Asn Leu Gly Ser Ser Phe Ala Gly Leu Ala Val Leu Asp Trp
        115                 120                 125             
Glu Glu Trp Tyr Pro Leu Trp Ala Gly Asn Trp Gly Thr His Arg Gln
    130                 135                 140                 
Val Tyr Gln Ala Ala Ser Trp Ala Trp Ala Gln Gln Met Phe Pro Asp
145                 150                 155                 160 
Leu Asn Pro Gln Glu Gln Leu His Lys Ala Gln Thr Gly Phe Glu Gln
                165                 170                 175     
Ala Ala Arg Ala Leu Met Glu His Thr Leu Arg Leu Gly Gln Met Leu
            180                 185                 190         
Arg Pro His Gly Leu Trp Gly Phe Tyr Arg Tyr Pro Val Cys Gly Asn
        195                 200                 205             
Gly Trp His Asn Met Ala Ser Asn Tyr Thr Gly His Cys His Pro Ala
    210                 215                 220                 
Ile Ile Thr Arg Asn Thr Gln Leu Arg Trp Leu Trp Ala Ala Ser Ser
225                 230                 235                 240 
Ala Leu Phe Pro Ser Ile Tyr Leu Pro Pro Arg Leu Pro Pro Ala Tyr
                245                 250                 255     
His Gln Thr Phe Val Arg His Arg Leu Glu Glu Ala Phe Arg Val Ala
            260                 265                 270         
Leu Thr Gly His Ala His Pro Leu Pro Val Leu Ala Tyr Val Arg Leu
        275                 280                 285             
Thr His Arg Ser Ser Gly Arg Phe Leu Ser Leu Asp Asp Leu Met Gln
    290                 295                 300                 
Thr Ile Gly Val Ser Ala Ala Leu Gly Ala Ala Gly Val Val Leu Trp
305                 310                 315                 320 
Gly Asp Leu Ser Val Ser Ser Ser Glu Glu Glu Cys Trp Arg Leu His
                325                 330                 335     
Asp Tyr Leu Val Gly Thr Leu Gly Pro Tyr Val Ile Asn Val Thr Lys
            340                 345                 350         
Ala Ala Thr Ala Cys Ser His Gln Arg Cys His Gly His Gly Arg Cys
        355                 360                 365             
Ser Trp Lys Asp Pro Gly Gln Met Glu Ala Phe Leu His Leu Gln Pro
    370                 375                 380                 

Asp Asp Asn Leu Gly Ala Trp Lys Ser Phe Arg Cys Arg Cys Tyr Leu
385                 390                 395                 400 
Gly Trp Ser Gly Pro Thr Cys Leu Glu Pro Lys Pro
                405                 410         


<210> 251
<211> 545

<212> PRT
<213> Oryctolagus cuniculus

<220> 
<223> PH20

<400> 251
Met Gly Val Leu Lys Phe Lys His Ile Phe Phe Gly Ser Ala Val Glu
 1               5                  10                  15      
Leu Ser Gly Val Phe Gln Ile Val Phe Ile Phe Leu Leu Ile Pro Cys
            20                  25                  30          
Cys Leu Thr Ala Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro
        35                  40                  45              
Phe Leu Trp Ala Trp Asn Ala Pro Thr Glu Phe Cys Leu Gly Lys Ser
    50                  55                  60                  
Gly Glu Pro Leu Asp Met Ser Leu Phe Ser Leu Phe Gly Ser Pro Arg
65                  70                  75                  80  
Lys Asn Lys Thr Gly Gln Gly Ile Thr Ile Phe Tyr Val Asp Arg Leu
                85                  90                  95      
Gly Tyr Tyr Pro Tyr Ile Asp Pro His Thr Gly Ala Ile Val His Gly
            100                 105                 110         
Arg Ile Pro Gln Leu Gly Pro Leu Gln Gln His Leu Thr Lys Leu Arg
        115                 120                 125             
Gln Glu Ile Leu Tyr Tyr Met Pro Lys Asp Asn Val Gly Leu Ala Val
    130                 135                 140                 
Ile Asp Trp Glu Glu Trp Leu Pro Thr Trp Leu Arg Asn Trp Lys Pro
145                 150                 155                 160 
Lys Asp Ile Tyr Arg Ile Lys Ser Ile Glu Leu Val Lys Ser Gln His
                165                 170                 175     
Pro Gln Tyr Asn His Ser Tyr Ala Thr Glu Lys Ala Lys Arg Asp Phe
            180                 185                 190         
Glu Lys Ala Gly Lys Asp Phe Met Glu Glu Thr Leu Lys Leu Gly Arg
        195                 200                 205             
Leu Leu Arg Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys
    210                 215                 220                 
Tyr Asn His His Tyr Asp Lys Pro Asn Leu Tyr Lys Gly Ser Cys Phe
225                 230                 235                 240 
Asp Ile Glu Lys Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Lys Glu
                245                 250                 255     
Ser Thr Ala Leu Phe Pro Ser Val Tyr Leu Thr Ser Arg Ala Arg Ser
            260                 265                 270         
Ala Thr Ala Leu Ser Lys Leu Tyr Val Val Arg Asn Arg Val His Glu
        275                 280                 285             
Ala Ile Arg Val Ser Lys Ile Pro Asp Asp Lys Ser Pro Leu Pro Asn
    290                 295                 300                 
Phe Val Tyr Thr Arg Leu Val Phe Thr Asp Gln Ile Phe Gln Phe Leu
305                 310                 315                 320 
Ser His His Asp Leu Val Tyr Thr Ile Gly Glu Ile Val Ala Leu Gly
                325                 330                 335     
Ala Ser Gly Ile Val Val Trp Gly Ser Gln Ser Leu Ala Arg Ser Met
            340                 345                 350         
Lys Ser Cys Leu His Leu Asp Asn Tyr Met Lys Thr Ile Leu Asn Pro
        355                 360                 365             
Tyr Leu Ile Asn Val Thr Leu Ala Ala Lys Met Cys Asn Gln Val Leu
    370                 375                 380                 
Cys Gln Glu Gln Gly Val Cys Thr Arg Lys Asn Trp Asn Pro Asn Asp
385                 390                 395                 400 
Tyr Leu His Leu Asn Pro Gly Asn Phe Ala Ile Gln Leu Gly Ser Asn
                405                 410                 415     
Gly Thr Tyr Lys Val Asp Gly Lys Pro Thr Leu Thr Asp Leu Glu Gln
            420                 425                 430         
Phe Ser Lys Asn Phe Gln Cys Ser Cys Tyr Thr Asn Leu Asn Cys Lys
        435                 440                 445             
Glu Arg Thr Asp Met Asn Asn Val Arg Thr Val Asn Val Cys Ala Val
    450                 455                 460                 
Glu Asn Val Cys Ile Asp Thr Asn Val Gly Pro Gln Ala Val Thr Tyr
465                 470                 475                 480 
Ala Pro Lys Glu Lys Lys Asp Val Ala His Ile Leu Ser Asn Thr Thr
                485                 490                 495     
Ser Ile Asn Ser Ser Thr Thr Met Ser Leu Pro Phe Pro Arg Lys His
            500                 505                 510         
Val Ser Gly Cys Leu Leu Val Leu Cys Met Tyr Ser Gln Tyr Leu Asn
        515                 520                 525             
Ile Cys Tyr Arg Leu Val Ala Ile Gly Ile Gln His Gly Tyr Tyr Leu
    530                 535                 540                 
Lys
545 


<210> 252
<211> 476
<212> PRT
<213> Ovis aries

<220> 
<223> hyaluronidase 2

<400> 252
Met Trp Thr Gly Leu Gly Pro Ala Val Thr Leu Ala Leu Val Leu Val
 1               5                  10                  15      
Val Ala Trp Ala Thr Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr
            20                  25                  30          
Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly
        35                  40                  45              
Pro Arg His Lys Met Pro Leu Asp Pro Lys Asp Met Lys Ala Phe Asp
    50                  55                  60                  
Val Gln Ala Ser Pro Asn Glu Gly Phe Val Asn Gln Asn Ile Thr Ile
65                  70                  75                  80  
Phe Tyr Arg Asp Arg Leu Gly Met Tyr Pro His Phe Asn Ser Val Gly
                85                  90                  95      
Arg Ser Val His Gly Gly Val Pro Gln Asn Gly Ser Leu Trp Val His
            100                 105                 110         
Leu Glu Met Leu Lys Gly His Val Glu His Tyr Ile Arg Thr Gln Glu
        115                 120                 125             
Pro Ala Gly Leu Ala Val Ile Asp Trp Glu Asp Trp Arg Pro Val Trp
    130                 135                 140                 
Val Arg Asn Trp Gln Asp Lys Asp Val Tyr Arg Arg Leu Ser Arg Gln
145                 150                 155                 160 
Leu Val Ala Ser His His Pro Asp Trp Pro Pro Glu Arg Ile Val Lys
                165                 170                 175     
Glu Ala Gln Tyr Glu Phe Glu Phe Ala Ala Arg Gln Phe Met Leu Glu
            180                 185                 190         
Thr Leu Arg Phe Val Lys Ala Phe Arg Pro Arg His Leu Trp Gly Phe
        195                 200                 205             
Tyr Leu Phe Pro Asp Cys Tyr Asn His Asp Tyr Val Gln Asn Trp Glu
    210                 215                 220                 
Thr Tyr Thr Gly Arg Cys Pro Asp Val Glu Val Ser Arg Asn Asp Gln
225                 230                 235                 240 
Leu Ser Trp Leu Trp Ala Glu Ser Thr Ala Leu Phe Pro Ser Val Tyr
                245                 250                 255     
Leu Glu Glu Thr Leu Ala Ser Ser Thr His Gly Arg Asn Phe Val Ser
            260                 265                 270         
Phe Arg Val Gln Glu Ala Leu Arg Val Ala Asp Val His His Ala Asn
        275                 280                 285             
His Ala Leu Pro Val Tyr Val Phe Thr Arg Pro Thr Tyr Ser Arg Gly
    290                 295                 300                 
Leu Thr Gly Leu Ser Glu Met Asp Leu Ile Ser Thr Ile Gly Glu Ser
305                 310                 315                 320 
Ala Ala Leu Gly Ala Ala Gly Val Ile Leu Trp Gly Asp Ala Gly Phe
                325                 330                 335     
Thr Thr Ser Asn Glu Thr Cys Arg Arg Leu Lys Asp Tyr Leu Thr Arg
            340                 345                 350         
Ser Leu Val Pro Tyr Val Val Asn Val Ser Trp Ala Ala Gln Tyr Cys
        355                 360                 365             
Ser Trp Ala Gln Cys His Gly His Gly Arg Cys Val Arg Arg Asp Pro
    370                 375                 380                 
Asn Ala His Thr Phe Leu His Leu Ser Ala Ser Ser Phe Arg Leu Val
385                 390                 395                 400 
Pro Ser His Ala Pro Asp Glu Pro Arg Leu Arg Pro Glu Gly Glu Leu
                405                 410                 415     
Ser Trp Ala Asp Arg Asn His Leu Gln Thr His Phe Arg Cys Gln Cys
            420                 425                 430         
Tyr Leu Gly Trp Gly Gly Glu Gln Cys Gln Trp Asp Arg Arg Arg Ala
        435                 440                 445             
Ala Gly Gly Ala Ser Gly Ala Trp Ala Gly Ser His Leu Thr Gly Leu
    450                 455                 460                 
Leu Ala Val Ala Val Leu Ala Phe Thr Trp Thr Ser
465                 470                 475     


<210> 253
<211> 414
<212> PRT
<213> Pongo pygmaeus

<220> 
<223> hyaluronidase 3

<400> 253
Met Thr Thr Arg Leu Gly Pro Ala Leu Val Leu Gly Val Ala Leu Cys
 1               5                  10                  15      
Leu Gly Cys Gly Gln Pro Leu Pro Gln Val Pro Glu Arg Pro Phe Ser
            20                  25                  30          
Val Leu Trp Asn Val Pro Ser Ala His Cys Lys Ser Arg Phe Gly Val
        35                  40                  45              
His Leu Pro Leu Asn Ala Leu Gly Ile Ile Ala Asn Arg Gly Gln His
    50                  55                  60                  
Phe His Gly Gln Asn Met Thr Ile Phe Tyr Lys Asn Gln Leu Gly Leu
65                  70                  75                  80  
Tyr Pro Tyr Phe Gly Pro Lys Gly Thr Ala His Asn Gly Gly Ile Pro
                85                  90                  95      
Gln Ala Leu Pro Leu Asp Arg His Leu Ala Leu Ala Ala Tyr Gln Ile
            100                 105                 110         
His His Ser Leu Arg Pro Gly Phe Ala Gly Pro Ala Val Leu Asp Trp
        115                 120                 125             
Glu Glu Trp Cys Pro Leu Trp Ala Gly Asn Trp Gly Arg Arg Arg Ala
    130                 135                 140                 
Tyr Gln Ala Ala Ser Trp Ala Trp Ala Gln Gln Val Phe Pro Asp Leu
145                 150                 155                 160 
Asp Pro Gln Glu Gln Leu Tyr Lys Ala Tyr Thr Gly Phe Glu Gln Ala
                165                 170                 175     
Ala Arg Ala Leu Met Glu Asp Thr Leu Arg Val Ala Gln Ala Leu Arg
            180                 185                 190         
Pro His Gly Leu Trp Gly Phe Tyr His Tyr Pro Ala Cys Gly Asn Gly
        195                 200                 205             
Trp His Ser Met Ala Ser Asn Tyr Thr Gly Arg Cys His Ala Ala Thr
    210                 215                 220                 
Leu Ala Arg Asn Thr Gln Leu His Trp Leu Trp Ala Ala Ser Ser Ala
225                 230                 235                 240 
Leu Phe Pro Ser Ile Tyr Leu Pro Pro Arg Leu Pro Pro Ala His His
                245                 250                 255     
Gln Ala Phe Val Arg His Arg Leu Glu Glu Ala Phe Arg Val Ala Leu
            260                 265                 270         
Val Gly His Leu Pro Val Leu Ala Tyr Val Arg Leu Thr His Arg Arg
        275                 280                 285             
Ser Gly Arg Phe Leu Ser Gln Asp Asp Leu Val Gln Thr Ile Gly Val
    290                 295                 300                 
Ser Ala Ala Leu Gly Ala Ala Gly Val Val Leu Trp Gly Asp Leu Ser
305                 310                 315                 320 

Leu Ser Ser Ser Glu Glu Glu Cys Trp His Leu His Asp Tyr Leu Val
                325                 330                 335     
Asp Thr Leu Gly Pro Tyr Gly Ile Asn Val Thr Arg Ala Ala Met Ala
            340                 345                 350         
Cys Ser His Gln Arg Cys His Gly His Gly Arg Cys Ala Arg Arg Asp
        355                 360                 365             
Pro Gly Gln Met Glu Ala Phe Leu His Leu Trp Pro Asp Gly Ser Leu
    370                 375                 380                 
Gly Asp Trp Lys Ser Phe Ser Cys His Cys Tyr Trp Gly Trp Ala Gly
385                 390                 395                 400 
Pro Thr Cys Gln Glu Pro Arg Leu Gly Pro Lys Glu Ala Val
                405                 410                 


<210> 254
<211> 510
<212> PRT
<213> Macaca fascicularis

<220> 
<223> PH20

<400> 254
Met Gly Val Leu Lys Phe Lys His Ile Phe Phe Arg Ser Phe Val Lys
 1               5                  10                  15      
Ser Ser Gly Val Ser Gln Ile Val Phe Thr Phe Leu Leu Ile Pro Cys
            20                  25                  30          
Cys Leu Thr Leu Asn Phe Arg Ala Pro Pro Ile Ile Pro Asn Val Pro
        35                  40                  45              
Phe Leu Trp Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe
    50                  55                  60                  
Asn Glu Pro Leu Asp Met Ser Leu Phe Thr Leu Met Gly Ser Pro Arg
65                  70                  75                  80  
Ile Asn Val Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu
                85                  90                  95      
Gly Tyr Tyr Pro Tyr Ile Asp Leu Thr Thr Gly Val Thr Val His Gly
            100                 105                 110         
Gly Ile Pro Gln Lys Val Ser Leu Gln Asp His Leu Asp Lys Ser Lys
        115                 120                 125             
Gln Asp Ile Leu Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val
    130                 135                 140                 

Ile Asp Trp Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro
145                 150                 155                 160 
Lys Asp Val Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn
                165                 170                 175     
Val Gln Leu Ser Leu Pro Gln Ala Thr Asp Lys Ala Lys Gln Glu Phe
            180                 185                 190         
Glu Lys Ala Gly Lys Asp Phe Met Leu Glu Thr Ile Lys Leu Gly Arg
        195                 200                 205             
Ser Leu Arg Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys
    210                 215                 220                 
Tyr Asn His His Tyr Arg Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asp
225                 230                 235                 240 
Val Glu Ile Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser
                245                 250                 255     
Thr Ala Leu Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Val Val
            260                 265                 270         
Val Ala Thr Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val
        275                 280                 285             
Ser Lys Ile Pro Asp Ala Lys Asn Pro Leu Pro Val Phe Val Tyr Ala
    290                 295                 300                 
Arg Leu Val Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Arg Glu Glu
305                 310                 315                 320 
Leu Val Ser Thr Leu Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile
                325                 330                 335     
Val Ile Trp Gly Ser Leu Ser Ile Thr Arg Ser Met Lys Ser Cys Leu
            340                 345                 350         
Leu Leu Asp Thr Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn
        355                 360                 365             
Val Thr Leu Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln
    370                 375                 380                 
Gly Val Cys Ile Arg Lys Asp Trp Asn Ser Ser Asp Tyr Leu His Leu
385                 390                 395                 400 
Asn Pro Asp Asn Phe Asp Ile Arg Leu Glu Lys Gly Gly Lys Phe Thr
                405                 410                 415     
Val His Gly Lys Pro Thr Val Glu Asp Leu Glu Glu Phe Ser Glu Lys
            420                 425                 430         
Phe Tyr Cys Ser Cys Tyr Thr Asn Leu Ser Cys Lys Glu Lys Ala Asp
        435                 440                 445             
Val Lys Asp Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys
    450                 455                 460                 
Ile Asp Ala Ser Leu Lys Pro Pro Val Glu Thr Glu Gly Ser Pro Pro
465                 470                 475                 480 
Ile Phe Tyr Asn Thr Ser Ser Ser Thr Val Ser Thr Thr Met Phe Ile

                485                 490                 495     
Val Asn Ile Leu Phe Leu Ile Ile Ser Ser Val Ala Ser Leu
            500                 505                 510 


<210> 255
<211> 529
<212> PRT
<213> Cavia porcellus

<220> 
<223> PH20

<400> 255
Met Gly Ala Phe Thr Phe Lys His Ser Phe Phe Gly Ser Phe Val Glu
 1               5                  10                  15      
Cys Ser Gly Val Leu Gln Thr Val Phe Ile Phe Leu Leu Ile Pro Cys
            20                  25                  30          
Cys Leu Ala Asp Lys Arg Ala Pro Pro Leu Ile Pro Asn Val Pro Leu
        35                  40                  45              
Leu Trp Val Trp Asn Ala Pro Thr Glu Phe Cys Ile Gly Gly Thr Asn
    50                  55                  60                  
Gln Pro Leu Asp Met Ser Phe Phe Ser Ile Val Gly Thr Pro Arg Lys
65                  70                  75                  80  
Asn Ile Thr Gly Gln Ser Ile Thr Leu Tyr Tyr Val Asp Arg Leu Gly
                85                  90                  95      
Tyr Tyr Pro Tyr Ile Asp Pro His Thr Gly Ala Ile Val His Gly Gly
            100                 105                 110         
Leu Pro Gln Leu Met Asn Leu Gln Gln His Leu Arg Lys Ser Arg Gln
        115                 120                 125             
Asp Ile Leu Phe Tyr Met Pro Thr Asp Ser Val Gly Leu Ala Val Ile
    130                 135                 140                 
Asp Trp Glu Glu Trp Arg Pro Thr Trp Thr Arg Asn Trp Arg Pro Lys
145                 150                 155                 160 
Asp Ile Tyr Arg Asn Lys Ser Ile Glu Leu Val Lys Ser Gln His Pro
                165                 170                 175     
Gln Tyr Asn His Ser Tyr Ala Val Ala Val Ala Lys Arg Asp Phe Glu
            180                 185                 190         
Arg Thr Gly Lys Ala Phe Met Leu Glu Thr Leu Lys Leu Gly Lys Ser
        195                 200                 205             
Leu Arg Pro Ser Ser Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys Tyr
    210                 215                 220                 
Asn Thr His Phe Thr Lys Pro Asn Tyr Asp Gly His Cys Pro Pro Ile
225                 230                 235                 240 
Glu Leu Gln Arg Asn Asn Asp Leu Gln Trp Leu Trp Asn Asp Ser Thr
                245                 250                 255     
Ala Leu Tyr Pro Ser Val Tyr Leu Thr Ser Arg Val Arg Ser Ser Gln
            260                 265                 270         
Asn Gly Ala Leu Tyr Val Arg Asn Arg Val His Glu Ser Ile Arg Val
        275                 280                 285             
Ser Lys Leu Met Asp Asp Lys Asn Pro Leu Pro Ile Tyr Val Tyr Ile
    290                 295                 300                 
Arg Leu Val Phe Thr Asp Gln Thr Thr Thr Phe Leu Glu Leu Asp Asp
305                 310                 315                 320 
Leu Val His Ser Val Gly Glu Ile Val Pro Leu Gly Val Ser Gly Ile
                325                 330                 335     
Ile Ile Trp Gly Ser Leu Ser Leu Thr Arg Ser Leu Val Ser Cys Ile
            340                 345                 350         
Gly Leu Glu Asn Tyr Met Lys Gly Thr Leu Leu Pro Tyr Leu Ile Asn
        355                 360                 365             
Val Thr Leu Ala Ala Lys Met Cys Gly Gln Val Leu Cys Lys Asn Gln
    370                 375                 380                 
Gly Ile Cys Thr Arg Lys Asp Trp Asn Thr Asn Thr Tyr Leu His Leu
385                 390                 395                 400 
Asn Ala Thr Asn Phe Asp Ile Glu Leu Gln Gln Asn Gly Lys Phe Val
                405                 410                 415     
Val His Gly Lys Pro Ser Leu Glu Asp Leu Gln Glu Phe Ser Lys Asn
            420                 425                 430         
Phe His Cys Ser Cys Tyr Thr Asn Val Ala Cys Lys Asp Arg Leu Asp
        435                 440                 445             
Val His Asn Val Arg Ser Val Asn Val Cys Thr Ala Asn Asn Ile Cys
    450                 455                 460                 
Ile Asp Ala Val Leu Asn Phe Pro Ser Leu Asp Asp Asp Asp Glu Pro
465                 470                 475                 480 
Pro Ile Thr Asp Asp Thr Ser Gln Asn Gln Asp Ser Ile Ser Asp Ile
                485                 490                 495     
Thr Ser Ser Ala Pro Pro Ser Ser His Ile Leu Pro Lys Asp Leu Ser
            500                 505                 510         
Trp Cys Leu Phe Leu Leu Ser Ile Phe Ser Gln His Trp Lys Tyr Leu
        515                 520                 525             
Leu
    


<210> 256
<211> 512
<212> PRT
<213> Rattus norvegicus

<220> 
<223> PH20

<400> 256
Met Gly Glu Leu Gln Phe Lys Trp Leu Phe Trp Arg Ser Phe Ala Glu
 1               5                  10                  15      
Ser Gly Gly Thr Phe Gln Thr Val Leu Ile Phe Leu Phe Ile Pro Tyr
            20                  25                  30          
Ser Leu Thr Val Asp Tyr Arg Ala Thr Pro Val Leu Ser Asp Thr Thr
        35                  40                  45              
Phe Val Trp Val Trp Asn Val Pro Thr Glu Ala Cys Val Glu Asn Val
    50                  55                  60                  
Thr Glu Pro Ile Asp Leu Ser Phe Phe Ser Leu Ile Gly Ser Pro Arg
65                  70                  75                  80  
Lys Thr Ala Ile Gly Gln Pro Val Thr Leu Phe Tyr Val Asp Arg Leu
                85                  90                  95      
Gly Asn Tyr Pro His Ile Asp Ala Gln Gln Thr Glu His His Gly Gly
            100                 105                 110         
Ile Pro Gln Lys Gly Asp Leu Thr Thr His Leu Val Lys Ala Lys Glu
        115                 120                 125             
Asp Val Glu Arg Tyr Ile Pro Thr Asp Lys Leu Gly Leu Ala Ile Ile
    130                 135                 140                 
Asp Trp Glu Glu Trp Arg Pro Thr Trp Met Arg Asn Trp Thr Pro Lys
145                 150                 155                 160 
Asp Ile Tyr Arg Asn Lys Ser Ile Glu Leu Val Gln Ala Ala Asp Pro
                165                 170                 175     
Ala Ile Asn Ile Thr Glu Ala Thr Val Arg Ala Lys Ala Gln Phe Glu
            180                 185                 190         
Gly Ala Ala Lys Glu Phe Met Glu Gly Thr Leu Lys Leu Gly Lys His
        195                 200                 205             
Ile Arg Pro Lys His Leu Trp Gly Phe Tyr Leu Phe Pro Asp Cys Tyr
    210                 215                 220                 
Asn Asn Lys Phe Gln Val Asp Asn Tyr Asp Gly Gln Cys Pro Asp Val
225                 230                 235                 240 
Glu Lys Lys Arg Asn Asp Asp Leu Asp Trp Leu Trp Lys Glu Ser Thr
                245                 250                 255     
Gly Leu Tyr Pro Ser Val Tyr Leu Lys Lys Asp Leu Lys Ser Ser Arg
            260                 265                 270         
Lys Ala Thr Leu Tyr Val Arg Tyr Arg Val Leu Glu Ser Ile Arg Val
        275                 280                 285             
Ser Lys Val Ser Asp Glu Ser Asn Pro Val Pro Ile Phe Val Tyr Ile
    290                 295                 300                 
Arg Leu Val Phe Thr Asp His Val Ser Glu Tyr Leu Leu Glu Asp Asp
305                 310                 315                 320 
Leu Val Asn Thr Ile Gly Glu Ile Val Ala Gln Gly Thr Ser Gly Ile
                325                 330                 335     
Ile Ile Trp Asp Ala Met Ser Leu Ala Gln Arg Ser Ala Gly Cys Pro
            340                 345                 350         
Ile Leu Arg Gln Tyr Met Lys Thr Thr Leu Asn Pro Tyr Ile Val Asn
        355                 360                 365             
Val Thr Leu Ala Ala Lys Met Cys Ser Gln Thr Leu Cys Lys Glu Lys
    370                 375                 380                 
Gly Met Cys Ser Arg Lys Thr Glu Ser Ser Asp Ala Tyr Leu His Leu
385                 390                 395                 400 
Asp Pro Ser Ser Phe Ser Ile Asn Val Thr Glu Ala Gly Lys Tyr Glu
                405                 410                 415     
Val Leu Gly Lys Pro Glu Val Lys Asp Leu Glu Tyr Phe Ser Glu His
            420                 425                 430         
Phe Lys Cys Ser Cys Phe Ser Lys Met Thr Cys Glu Glu Thr Ser Asp
        435                 440                 445             
Met Arg Ser Ile Gln Asp Val Asn Val Cys Met Gly Asp Asn Val Cys
    450                 455                 460                 
Ile Lys Ala Thr Leu Gly Pro Asn Ser Ala Phe His Leu Leu Pro Gly
465                 470                 475                 480 
Lys Gly Leu Leu Leu Met Thr Thr Leu Ala His Ile Leu His His Leu
                485                 490                 495     
Pro His Asp Ile Phe Val Phe Pro Trp Lys Met Leu Val Ser Thr Pro
            500                 505                 510         


<210> 257
<211> 512
<212> PRT
<213> Mus musculus

<220> 
<223> PH20

<400> 257
Met Gly Glu Leu Arg Phe Lys His Leu Phe Trp Gly Ser Phe Val Glu
 1               5                  10                  15      
Ser Gly Gly Thr Phe Gln Thr Val Leu Ile Phe Leu Leu Ile Pro Cys
            20                  25                  30          
Ser Leu Thr Val Asp Tyr Arg Ala Ala Pro Ile Leu Ser Asn Thr Thr
        35                  40                  45              
Phe Leu Trp Ile Trp Asn Val Pro Thr Glu Arg Cys Val Gly Asn Val
    50                  55                  60                  
Asn Asp Pro Ile Asp Leu Ser Phe Phe Ser Leu Ile Gly Ser Pro Arg
65                  70                  75                  80  
Lys Thr Ala Thr Gly Gln Pro Val Thr Leu Phe Tyr Val Asp Arg Leu
                85                  90                  95      
Gly Leu Tyr Pro His Ile Asp Ala Asn Gln Ala Glu His Tyr Gly Gly
            100                 105                 110         
Ile Pro Gln Arg Gly Asp Tyr Gln Ala His Leu Arg Lys Ala Lys Thr
        115                 120                 125             
Asp Ile Glu His Tyr Ile Pro Asp Asp Lys Leu Gly Leu Ala Ile Ile
    130                 135                 140                 
Asp Trp Glu Glu Trp Arg Pro Thr Trp Leu Arg Asn Trp Lys Pro Lys
145                 150                 155                 160 
Asp Asn Tyr Arg Asn Lys Ser Ile Glu Leu Val Gln Ser Thr Asn Pro
                165                 170                 175     
Gly Leu Ser Ile Thr Glu Ala Thr Gln Lys Ala Ile Gln Gln Phe Glu
            180                 185                 190         
Glu Ala Gly Arg Lys Phe Met Glu Gly Thr Leu His Leu Gly Lys Phe
        195                 200                 205             
Leu Arg Pro Asn Gln Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys Tyr
    210                 215                 220                 
Asn Asn Lys Phe Gln Asp Pro Lys Tyr Asp Gly Gln Cys Pro Ala Val
225                 230                 235                 240 
Glu Lys Lys Arg Asn Asp Asn Leu Lys Trp Leu Trp Lys Ala Ser Thr
                245                 250                 255     
Gly Leu Tyr Pro Ser Val Tyr Leu Lys Lys Asp Leu Lys Ser Asn Arg
            260                 265                 270         
Gln Ala Thr Leu Tyr Val Arg Tyr Arg Val Val Glu Ala Ile Arg Val
        275                 280                 285             
Ser Lys Val Gly Asn Ala Ser Asp Pro Val Pro Ile Phe Val Tyr Ile
    290                 295                 300                 
Arg Leu Val Phe Thr Asp Arg Thr Ser Glu Tyr Leu Leu Glu Asp Asp
305                 310                 315                 320 
Leu Val Asn Thr Ile Gly Glu Ile Val Ala Leu Gly Thr Ser Gly Ile
                325                 330                 335     
Ile Ile Trp Asp Ala Met Ser Leu Ala Gln Arg Ala Ala Gly Cys Pro
            340                 345                 350         
Ile Leu His Lys Tyr Met Gln Thr Thr Leu Asn Pro Tyr Ile Val Asn
        355                 360                 365             
Val Thr Leu Ala Ala Lys Met Cys Ser Gln Thr Leu Cys Asn Glu Lys
    370                 375                 380                 
Gly Met Cys Ser Arg Arg Lys Glu Ser Ser Asp Val Tyr Leu His Leu
385                 390                 395                 400 
Asn Pro Ser His Phe Asp Ile Met Leu Thr Glu Thr Gly Lys Tyr Glu
                405                 410                 415     
Val Leu Gly Asn Pro Arg Val Gly Asp Leu Glu Tyr Phe Ser Glu His
            420                 425                 430         
Phe Lys Cys Ser Cys Phe Ser Arg Met Thr Cys Lys Glu Thr Ser Asp
        435                 440                 445             
Val Lys Asn Val Gln Asp Val Asn Val Cys Val Gly Asp Asn Val Cys
    450                 455                 460                 
Ile Lys Ala Lys Val Glu Pro Asn Pro Ala Phe Tyr Leu Leu Pro Gly
465                 470                 475                 480 
Lys Ser Leu Leu Phe Met Thr Thr Leu Gly His Val Leu Tyr His Leu
                485                 490                 495     
Pro Gln Asp Ile Phe Val Phe Pro Arg Lys Thr Leu Val Ser Thr Pro
            500                 505                 510         


<210> 258
<211> 807
<212> PRT
<213> Staphylococcus aureus

<220> 
<223> hyaluronidase

<400> 258
Met Thr Tyr Arg Ile Lys Lys Trp Gln Lys Leu Ser Thr Ile Thr Leu
 1               5                  10                  15      
Leu Met Ala Gly Val Ile Thr Leu Asn Gly Gly Glu Phe Arg Ser Val
            20                  25                  30          
Asp Lys His Gln Ile Ala Val Ala Asp Thr Asn Val Gln Thr Pro Asp
        35                  40                  45              
Tyr Glu Lys Leu Arg Asn Thr Trp Leu Asp Val Asn Tyr Gly Tyr Asp
    50                  55                  60                  
Lys Tyr Asp Glu Asn Asn Pro Asp Met Lys Lys Lys Phe Asp Ala Thr
65                  70                  75                  80  
Glu Lys Glu Ala Thr Asn Leu Leu Lys Glu Met Lys Thr Glu Ser Gly
                85                  90                  95      
Arg Lys Tyr Leu Trp Ser Gly Ala Glu Thr Leu Glu Thr Asn Ser Ser
            100                 105                 110         
His Met Thr Arg Thr Tyr Arg Asn Ile Glu Lys Ile Ala Glu Ala Met
        115                 120                 125             
Arg Asn Pro Lys Thr Thr Leu Asn Thr Asp Glu Asn Lys Lys Lys Val
    130                 135                 140                 
Lys Asp Ala Leu Glu Trp Leu His Lys Asn Ala Tyr Gly Lys Glu Pro
145                 150                 155                 160 
Asp Lys Lys Val Lys Glu Leu Ser Glu Asn Phe Thr Lys Thr Thr Gly
                165                 170                 175     
Lys Asn Thr Asn Leu Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro Lys
            180                 185                 190         
Ser Leu Thr Asn Thr Leu Ile Leu Leu Asn Asp Gln Phe Ser Asn Glu
        195                 200                 205             
Glu Lys Lys Lys Phe Thr Ala Pro Ile Lys Thr Phe Ala Pro Asp Ser
    210                 215                 220                 
Asp Lys Ile Leu Ser Ser Val Gly Lys Ala Glu Leu Ala Lys Gly Gly
225                 230                 235                 240 
Asn Leu Val Asp Ile Ser Lys Val Lys Leu Leu Glu Cys Ile Ile Glu
                245                 250                 255     
Glu Asp Lys Asp Met Met Lys Lys Ser Ile Asp Ser Phe Asn Lys Val
            260                 265                 270         
Phe Thr Tyr Val Gln Asp Ser Ala Thr Gly Lys Glu Arg Asn Gly Phe
        275                 280                 285             
Tyr Lys Asp Gly Ser Tyr Ile Asp His Gln Asp Val Pro Tyr Thr Gly
    290                 295                 300                 
Ala Tyr Gly Val Val Leu Leu Glu Gly Ile Ser Gln Met Met Pro Met
305                 310                 315                 320 
Ile Lys Glu Thr Pro Phe Asn Asp Lys Thr Gln Asn Asp Thr Thr Leu
                325                 330                 335     
Lys Ser Trp Ile Asp Asp Gly Phe Met Pro Leu Ile Tyr Lys Gly Glu
            340                 345                 350         
Met Met Asp Leu Ser Arg Gly Arg Ala Ile Ser Arg Glu Asn Glu Thr
        355                 360                 365             
Ser His Ser Ala Ser Ala Thr Val Met Lys Ser Leu Leu Arg Leu Ser
    370                 375                 380                 
Asp Ala Met Asp Asp Ser Thr Lys Ala Lys Tyr Lys Lys Ile Val Lys
385                 390                 395                 400 
Ser Ser Val Glu Ser Asp Ser Ser Tyr Lys Gln Asn Asp Tyr Leu Asn
                405                 410                 415     
Ser Tyr Ser Asp Ile Asp Lys Met Lys Ser Leu Met Thr Asp Asn Ser
            420                 425                 430         
Ile Ser Lys Asn Gly Leu Thr Gln Gln Leu Lys Ile Tyr Asn Asp Met
        435                 440                 445             
Asp Arg Val Thr Tyr His Asn Lys Asp Leu Asp Phe Ala Phe Gly Leu
    450                 455                 460                 
Ser Met Thr Ser Lys Asn Val Ala Arg Tyr Glu Ser Ile Asn Gly Glu
465                 470                 475                 480 
Asn Leu Lys Gly Trp His Thr Gly Ala Gly Met Ser Tyr Leu Tyr Asn
                485                 490                 495     
Ser Asp Val Lys His Tyr His Asp Asn Phe Trp Val Thr Ala Asp Met
            500                 505                 510         
Lys Arg Leu Ser Gly Thr Thr Thr Leu Asp Asn Glu Ile Leu Lys Asp
        515                 520                 525             
Thr Asp Asp Lys Lys Ser Ser Lys Thr Phe Val Gly Gly Thr Lys Val
    530                 535                 540                 
Asp Asp Gln His Ala Ser Ile Gly Met Asp Phe Glu Asn Gln Asp Lys
545                 550                 555                 560 
Thr Leu Thr Ala Lys Lys Ser Tyr Phe Ile Leu Asn Asp Lys Ile Val
                565                 570                 575     
Phe Leu Gly Thr Gly Ile Lys Ser Thr Asp Ser Ser Lys Asn Pro Val
            580                 585                 590         
Thr Thr Ile Glu Asn Arg Lys Ala Asn Gly Tyr Thr Leu Tyr Thr Asp
        595                 600                 605             
Asp Lys Gln Thr Thr Asn Ser Asp Asn Gln Glu Asn Asn Ser Val Phe
    610                 615                 620                 
Leu Glu Ser Thr Asp Thr Lys Lys Asn Ile Gly Tyr His Phe Leu Asn
625                 630                 635                 640 
Lys Pro Lys Ile Thr Val Lys Lys Glu Ser His Thr Gly Lys Trp Lys
                645                 650                 655     
Glu Ile Asn Lys Ser Gln Lys Asp Thr Gln Lys Thr Asp Glu Tyr Tyr
            660                 665                 670         
Glu Val Thr Gln Lys His Ser Asn Ser Asp Asn Lys Tyr Gly Tyr Val
        675                 680                 685             
Leu Tyr Pro Gly Leu Ser Lys Asp Val Phe Lys Thr Lys Lys Asp Glu
    690                 695                 700                 
Val Thr Val Val Lys Gln Glu Asp Asp Phe His Val Val Lys Asp Asn
705                 710                 715                 720 
Glu Ser Val Trp Ala Gly Val Asn Tyr Ser Asn Ser Thr Gln Thr Phe
                725                 730                 735     
Asp Ile Asn Asn Thr Lys Val Glu Val Lys Ala Lys Gly Met Phe Ile
            740                 745                 750         
Leu Lys Lys Lys Asp Asp Asn Thr Tyr Glu Cys Ser Phe Tyr Asn Pro
        755                 760                 765             
Glu Ser Thr Asn Ser Ala Ser Asp Ile Glu Ser Lys Ile Ser Met Thr
    770                 775                 780                 

Gly Tyr Ser Ile Thr Asn Lys Asn Thr Ser Thr Ser Asn Glu Ser Gly
785                 790                 795                 800 
Val His Phe Glu Leu Thr Lys
                805         


<210> 259
<211> 371
<212> PRT
<213> Streptococcus pyogenes bacteriophage H4489A

<220> 
<223> hyaluronidase

<400> 259
Met Thr Glu Asn Ile Pro Leu Arg Val Gln Phe Lys Arg Met Ser Ala
 1               5                  10                  15      
Asp Glu Trp Ala Arg Ser Asp Val Ile Leu Leu Glu Gly Glu Ile Gly
            20                  25                  30          
Phe Glu Thr Asp Thr Gly Phe Ala Lys Phe Gly Asp Gly Gln Asn Thr
        35                  40                  45              
Phe Ser Lys Leu Lys Tyr Leu Thr Gly Pro Lys Gly Pro Lys Gly Asp
    50                  55                  60                  
Thr Gly Leu Gln Gly Lys Thr Gly Gly Thr Gly Pro Arg Gly Pro Ala
65                  70                  75                  80  
Gly Lys Pro Gly Thr Thr Asp Tyr Asp Gln Leu Gln Asn Lys Pro Asp
                85                  90                  95      
Leu Gly Ala Phe Ala Gln Lys Glu Glu Thr Asn Ser Lys Ile Thr Lys
            100                 105                 110         
Leu Glu Ser Ser Lys Ala Asp Lys Ser Ala Val Tyr Ser Lys Ala Glu
        115                 120                 125             
Ser Lys Ile Glu Leu Asp Lys Lys Leu Ser Leu Thr Gly Gly Ile Val
    130                 135                 140                 
Thr Gly Gln Leu Gln Phe Lys Pro Asn Lys Ser Gly Ile Lys Pro Ser
145                 150                 155                 160 
Ser Ser Val Gly Gly Ala Ile Asn Ile Asp Met Ser Lys Ser Glu Gly
                165                 170                 175     
Ala Ala Met Val Met Tyr Thr Asn Lys Asp Thr Thr Asp Gly Pro Leu
            180                 185                 190         
Met Ile Leu Arg Ser Asp Lys Asp Thr Phe Asp Gln Ser Ala Gln Phe
        195                 200                 205             
Val Asp Tyr Ser Gly Lys Thr Asn Ala Val Asn Ile Val Met Arg Gln
    210                 215                 220                 
Pro Ser Ala Pro Asn Phe Ser Ser Ala Leu Asn Ile Thr Ser Ala Asn
225                 230                 235                 240 
Glu Gly Gly Ser Ala Met Gln Ile Arg Gly Val Glu Lys Ala Leu Gly
                245                 250                 255     
Thr Leu Lys Ile Thr His Glu Asn Pro Asn Val Glu Ala Lys Tyr Asp
            260                 265                 270         
Glu Asn Ala Ala Ala Leu Ser Ile Asp Ile Val Lys Lys Gln Lys Gly
        275                 280                 285             
Gly Lys Gly Thr Ala Ala Gln Gly Ile Tyr Ile Asn Ser Thr Ser Gly
    290                 295                 300                 
Thr Ala Gly Lys Met Leu Arg Ile Arg Asn Lys Asn Glu Asp Lys Phe
305                 310                 315                 320 
Tyr Val Gly Pro Asp Gly Gly Phe His Ser Gly Ala Asn Ser Thr Val
                325                 330                 335     
Ala Gly Asn Leu Thr Val Lys Asp Pro Thr Ser Gly Lys His Ala Ala
            340                 345                 350         
Thr Lys Asp Tyr Val Asp Glu Lys Ile Ala Glu Leu Lys Lys Leu Ile
        355                 360                 365             
Leu Lys Lys
    370     


<210> 260
<211> 1628
<212> PRT
<213> Clostridium perfringens

<220> 
<223> hyaluronidase

<400> 260
Met Asn Lys Asn Ile Arg Lys Ile Ile Thr Ser Thr Val Leu Ala Ala
 1               5                  10                  15      
Met Thr Ile Ser Val Leu Pro Ser Asn Leu Val Val Phe Ala Thr Asp
            20                  25                  30          
Gly Ile Thr Glu Asn Phe Tyr Glu Ile Tyr Pro Lys Pro Gln Glu Ile
        35                  40                  45              
Ser Tyr Ser Gly Gly Glu Phe Gln Ile Ser Asp Glu Ile Asn Ile Val
    50                  55                  60                  
Tyr Asp Asp Gly Ile Asp Thr Tyr Thr Lys Lys Arg Val Asp Glu Val
65                  70                  75                  80  
Leu Glu Ala Ser Asn Leu Glu Ala Thr Val Ser Asn Glu Ile Val Pro
                85                  90                  95      
Gly Lys Thr Asn Phe Leu Val Gly Ile Asn Glu Ser Gly Gly Val Val
            100                 105                 110         
Asp Asn Tyr Phe Asn Lys Asn Ile Pro His Asp Glu Ser Phe Phe Asp
        115                 120                 125             
Glu Lys Met Asp Ala Asn Ile Val Ser Val Lys Asp Gly Val Ile Gly
    130                 135                 140                 
Val Ile Gly Glu Asp Thr Asp Ser Ala Phe Tyr Gly Val Thr Thr Leu
145                 150                 155                 160 
Lys His Val Phe Asn Gln Leu Glu Glu Gly Asn Lys Ile Gln Ser Phe
                165                 170                 175     
Arg Ala Asp Asp Tyr Ala Glu Val Ala His Arg Gly Phe Ile Glu Gly
            180                 185                 190         
Tyr Tyr Gly Asn Pro Trp Ser Asn Glu Asp Arg Ala Glu Leu Met Lys
        195                 200                 205             
Phe Gly Gly Asp Tyr Lys Leu Asn Gln Tyr Val Phe Ala Pro Lys Asp
    210                 215                 220                 
Asp Pro Tyr His Asn Ser Lys Trp Arg Asp Leu Tyr Pro Glu Glu Lys
225                 230                 235                 240 
Leu Ser Glu Ile Lys Lys Leu Ala Gln Val Gly Asn Glu Thr Lys Asn
                245                 250                 255     
Arg Tyr Val Tyr Ala Leu His Pro Phe Met Asn Asn Pro Val Arg Phe
            260                 265                 270         
Asp Thr Glu Glu Asn Tyr Gln Asn Asp Leu Gly Val Ile Lys Ala Lys
        275                 280                 285             
Phe Thr Gln Leu Leu Glu Asn Asp Val Arg Gln Phe Ala Ile Leu Ala
    290                 295                 300                 
Asp Asp Ala Ser Ala Pro Ala Gln Gly Ala Ser Met Tyr Val Lys Leu
305                 310                 315                 320 
Leu Thr Asp Leu Thr Arg Trp Leu Glu Glu Gln Gln Ser Thr Tyr Pro
                325                 330                 335     
Asp Leu Lys Thr Asp Leu Met Phe Cys Pro Ser Asp Tyr Tyr Gly Asn
            340                 345                 350         
Gly Ser Ser Ala Gln Leu Lys Glu Leu Asn Lys Ala Glu Asp Asn Val
        355                 360                 365             
Ser Ile Val Met Thr Gly Gly Arg Ile Trp Gly Glu Val Asp Glu Asn
    370                 375                 380                 
Phe Ala Asn Asn Phe Met Asn Asn Ile Ser Thr Glu Gly His Pro Gly
385                 390                 395                 400 
Arg Ala Pro Phe Phe Trp Ile Asn Trp Pro Cys Ser Asp Asn Ser Lys
                405                 410                 415     
Gln His Leu Ile Met Gly Gly Asn Asp Thr Phe Leu His Pro Gly Val
            420                 425                 430         
Asp Pro Ser Lys Ile Asp Gly Ile Val Leu Asn Pro Met Gln Gln Ala
        435                 440                 445             
Glu Ala Asn Lys Ser Ala Leu Phe Ala Ile Ala Asp Tyr Ala Trp Asn
    450                 455                 460                 
Ile Trp Asp Asn Lys Glu Glu Ala Asp Glu Asn Trp Asn Asp Ser Phe
465                 470                 475                 480 
Lys Tyr Met Asp His Gly Thr Ala Glu Glu Thr Asn Ser Ser Leu Ala
                485                 490                 495     
Leu Arg Glu Ile Ser Lys His Met Ile Asn Gln Asn Met Asp Gly Arg
            500                 505                 510         
Val Arg Pro Leu Gln Glu Ser Val Glu Leu Ala Pro Lys Leu Glu Ala
        515                 520                 525             
Phe Lys Gln Lys Tyr Asp Ser Gly Ala Ser Ile Lys Glu Asp Ala Leu
    530                 535                 540                 
Glu Leu Ile Ala Glu Phe Thr Asn Leu Gln Lys Ala Ala Asp Tyr Tyr
545                 550                 555                 560 
Lys Asn Asn Pro Gly Asn Glu Arg Thr Arg Asp Gln Ile Ile Tyr Trp
                565                 570                 575     
Leu Asn Cys Trp Glu Asp Thr Met Asp Ala Ala Ile Gly Tyr Leu Lys
            580                 585                 590         
Ser Ala Ile Ala Ile Glu Glu Gly Asp Asp Glu Ala Ala Trp Ala Asn
        595                 600                 605             
Tyr Ser Glu Ala Gln Gly Ala Phe Glu Lys Ser Lys Thr Tyr Gly Phe
    610                 615                 620                 
His Tyr Val Asp His Thr Glu Tyr Ala Glu Val Gly Val Gln His Ile
625                 630                 635                 640 
Val Pro Phe Ile Lys Ser Met Gly Gln Asn Leu Ser Val Val Ile Gly
                645                 650                 655     
Ser Ile Val Asp Pro Asn Arg Ile Ile Ala Thr Tyr Ile Ser Asn Arg
            660                 665                 670         
Gln Asp Ala Pro Thr Gly Asn Pro Asp Asn Ile Phe Asp Asn Asn Ala
        675                 680                 685             
Ser Thr Glu Leu Val Tyr Lys Asn Pro Asn Arg Ile Asp Val Gly Thr
    690                 695                 700                 
Tyr Val Gly Val Lys Tyr Ser Asn Pro Ile Thr Leu Asn Asn Val Glu
705                 710                 715                 720 
Phe Leu Met Gly Ala Asn Ser Asn Pro Asn Asp Thr Met Gln Lys Ala
                725                 730                 735     
Lys Ile Gln Tyr Thr Val Asp Gly Arg Glu Trp Ile Asp Leu Glu Glu
            740                 745                 750         
Gly Val Glu Tyr Thr Met Pro Gly Ala Ile Lys Val Glu Asn Leu Asp
        755                 760                 765             
Leu Lys Val Arg Gly Val Arg Leu Ile Ala Thr Glu Ala Arg Glu Asn
    770                 775                 780                 
Thr Trp Leu Gly Val Arg Asp Ile Asn Val Asn Lys Lys Glu Asp Ser
785                 790                 795                 800 
Asn Ser Gly Val Glu Phe Asn Pro Ser Leu Ile Arg Ser Glu Ser Trp
                805                 810                 815     
Gln Val Tyr Glu Gly Asn Glu Ala Asn Leu Leu Asp Gly Asp Asp Asn
            820                 825                 830         
Thr Gly Val Trp Tyr Lys Thr Leu Asn Gly Asp Thr Ser Leu Ala Gly
        835                 840                 845             
Glu Phe Ile Gly Leu Asp Leu Gly Lys Glu Ile Lys Leu Asp Gly Ile
    850                 855                 860                 
Arg Phe Val Ile Gly Lys Asn Gly Gly Gly Ser Ser Asp Lys Trp Asn
865                 870                 875                 880 
Lys Phe Lys Leu Glu Tyr Ser Leu Asp Asn Glu Ser Trp Thr Thr Ile
                885                 890                 895     
Lys Glu Tyr Asp Lys Thr Gly Ala Pro Ala Gly Lys Asp Val Ile Glu
            900                 905                 910         
Glu Ser Phe Glu Thr Pro Ile Ser Ala Lys Tyr Ile Arg Leu Thr Asn
        915                 920                 925             
Met Glu Asn Ile Asn Lys Trp Leu Thr Phe Ser Glu Phe Ala Ile Ile
    930                 935                 940                 
Ser Asp Glu Leu Glu Asn Ala Gly Asn Lys Glu Asn Val Tyr Thr Asn
945                 950                 955                 960 
Thr Glu Leu Asp Leu Leu Ser Leu Ala Lys Glu Asp Val Thr Lys Leu
                965                 970                 975     
Ile Pro Thr Asp Asp Ile Ser Leu Asn His Gly Glu Tyr Ile Gly Val
            980                 985                 990         
Lys Leu Asn Arg Ile Lys Asp Leu Ser Asn Ile Asn Leu Glu Ile Ser
        995                 1000                1005            
Asn Asp Thr Gly Leu Lys Leu Gln Ser Ser Met Asn Gly Val Glu Trp
    1010                1015                1020                
Thr Glu Ile Thr Asp Lys Asn Thr Leu Glu Asp Gly Arg Tyr Val Arg
1025                1030                1035               1040 
Leu Ile Asn Thr Ser Asn Glu Ala Val Asn Phe Asn Leu Thr Lys Phe
                1045                1050                1055    
Glu Val Asn Ser Asn Glu Val Tyr Glu Pro Ser Leu Val Asp Ala Tyr
            1060                1065                1070        
Val Gly Asp Asp Gly Ala Lys Lys Ala Val Asp Gly Asp Leu Lys Thr
        1075                1080                1085            
Arg Val Lys Phe Leu Gly Ala Pro Ser Thr Gly Asp Thr Ile Val Tyr
    1090                1095                1100                
Asp Leu Gly Gln Glu Ile Leu Val Asp Asn Leu Lys Tyr Val Val Leu
1105                1110                1115               1120 
Asp Thr Glu Val Asp His Val Arg Asp Gly Lys Ile Gln Leu Ser Leu
                1125                1130                1135    
Asp Gly Glu Thr Trp Thr Asp Ala Ile Thr Ile Gly Asp Gly Val Glu
            1140                1145                1150        
Asn Gly Val Asp Asp Met Phe Ser Thr Pro Leu Lys Asn Gly Tyr Lys
        1155                1160                1165            
His Gly Asn Gln Ser Gly Gly Ile Val Pro Ile Asp Ser Ala Tyr Val
    1170                1175                1180                
Glu Gly Asp Asn Leu Asn Gln Lys Ala Arg Tyr Val Arg Ile Leu Phe
1185                1190                1195               1200 
Thr Ala Pro Tyr Arg His Arg Trp Thr Val Ile Asn Glu Leu Met Ile
                1205                1210                1215    
Asn Asn Gly Glu Tyr Ile Ser Thr Val Asn Asp Pro Thr Tyr Ile Ser
            1220                1225                1230        
Asn Pro Ile Glu Glu Arg Gly Phe Ala Pro Ser Asn Leu Arg Asp Gly
        1235                1240                1245            
Asn Leu Thr Thr Ser Tyr Lys Pro Asn Thr Asn Asn Gly Glu Ile Ser
    1250                1255                1260                

Glu Gly Ser Ile Thr Tyr Arg Leu Ser Glu Lys Thr Asp Val Arg Lys
1265                1270                1275               1280 
Val Thr Ile Val Gln Ser Gly Ser Ser Ile Ser Asn Ala Lys Val Met
                1285                1290                1295    
Ala Arg Val Gly Asp Gly Ser Glu Asn Val Thr Asp Gln Trp Val Gln
            1300                1305                1310        
Leu Gly Thr Leu Ser Asn Ser Leu Asn Glu Phe Ile Asn Arg Asp Tyr
        1315                1320                1325            
Asn Asn Ile Tyr Glu Ile Lys Ile Glu Trp Thr Asp Val Ala Pro Asn
    1330                1335                1340                
Ile Tyr Glu Ile Ile Thr Leu Asn Gln Glu Phe Glu Phe Pro Val Asn
1345                1350                1355               1360 
Asp Ser Leu Lys Ala Lys Tyr Asp Glu Leu Ile Asn Leu Ser Gly Asp
                1365                1370                1375    
Glu Tyr Thr Leu Ser Ser Phe Glu Thr Leu Lys Glu Ala Leu Asn Glu
            1380                1385                1390        
Ala Lys Ser Ile Leu Asp Asp Ser Asn Ser Ser Gln Lys Lys Ile Asp
        1395                1400                1405            
Lys Ala Leu Glu Lys Leu Asn Lys Ala Glu Glu Arg Leu Asp Leu Arg
    1410                1415                1420                
Ala Thr Asp Phe Glu Asp Phe Asn Lys Val Leu Thr Leu Gly Asn Ser
1425                1430                1435               1440 
Leu Val Glu Glu Glu Tyr Thr Ala Glu Ser Trp Ala Leu Phe Ser Glu
                1445                1450                1455    
Val Leu Glu Ala Ala Asn Glu Ala Asn Lys Asn Lys Ala Asp Tyr Thr
            1460                1465                1470        
Gln Asp Gln Ile Asn Gln Ile Val Ile Asp Leu Asp Ala Ser Ile Lys
        1475                1480                1485            
Ala Leu Val Lys Glu Thr Pro Glu Val Asp Lys Thr Asn Leu Gly Glu
    1490                1495                1500                
Leu Ile Asn Gln Gly Lys Ser Leu Leu Asp Glu Ser Val Glu Gly Phe
1505                1510                1515               1520 
Asn Val Gly Glu Tyr His Lys Gly Ala Lys Asp Gly Leu Thr Val Glu
                1525                1530                1535    
Ile Asn Lys Ala Glu Glu Val Phe Asn Lys Glu Asp Ala Thr Glu Glu
            1540                1545                1550        
Glu Ile Asn Leu Ala Lys Glu Ser Leu Glu Gly Ala Ile Ala Arg Phe
        1555                1560                1565            
Asn Ser Leu Leu Ile Glu Glu Ser Thr Gly Asp Phe Asn Gly Asn Gly
    1570                1575                1580                
Lys Ile Asp Ile Gly Asp Leu Ala Met Val Ser Lys Asn Ile Gly Ser
1585                1590                1595               1600 
Thr Thr Asn Thr Ser Leu Asp Leu Asn Lys Asp Gly Ser Ile Asp Glu

                1605                1610                1615    
Tyr Glu Ile Ser Phe Ile Asn His Arg Ile Leu Asn
            1620                1625            


<210> 261
<211> 186
<212> PRT
<213> Mus musculus

<220> 
<223> dihydrofolate reductase

<400> 261
Val Arg Pro Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile
 1               5                  10                  15      
Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Lys
            20                  25                  30          
Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn
        35                  40                  45              
Leu Val Ile Met Gly Arg Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn
    50                  55                  60                  
Arg Pro Leu Lys Asp Arg Ile Asn Ile Val Leu Ser Arg Glu Leu Lys
65                  70                  75                  80  
Glu Pro Pro Arg Gly Ala His Phe Leu Ala Lys Ser Leu Asp Asp Ala
                85                  90                  95      
Leu Arg Leu Ile Glu Gln Pro Glu Leu Ala Ser Lys Val Asp Met Val
            100                 105                 110         
Trp Ile Val Gly Gly Ser Ser Val Tyr Gln Glu Ala Met Asn Gln Pro
        115                 120                 125             
Gly His Leu Arg Leu Phe Val Thr Arg Ile Met Gln Glu Phe Glu Ser
    130                 135                 140                 
Asp Thr Phe Phe Pro Glu Ile Asp Leu Gly Lys Tyr Lys Leu Leu Pro
145                 150                 155                 160 
Glu Tyr Pro Gly Val Leu Ser Glu Val Gln Glu Glu Lys Gly Ile Lys
                165                 170                 175     
Tyr Lys Phe Glu Val Tyr Glu Lys Lys Asp
            180                 185     


<210> 262
<211> 435
<212> PRT
<213> Homo sapiens

<220> 
<223> Hyaluronidase-1 [Precursor]

<400> 262
Met Ala Ala His Leu Leu Pro Ile Cys Ala Leu Phe Leu Thr Leu Leu
 1               5                  10                  15      
Asp Met Ala Gln Gly Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe
            20                  25                  30          
Thr Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly
        35                  40                  45              
Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln
    50                  55                  60                  
Thr Phe Arg Gly Pro Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly
65                  70                  75                  80  
Thr Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu
                85                  90                  95      
Pro Gln Asn Ala Ser Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp
            100                 105                 110         
Ile Leu Ala Ala Ile Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile
        115                 120                 125             
Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys
    130                 135                 140                 
Asp Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro
145                 150                 155                 160 
Asp Trp Pro Ala Pro Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln
                165                 170                 175     
Gly Ala Ala Arg Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala
            180                 185                 190         
Leu Arg Pro Arg Gly Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr
        195                 200                 205             
Asn Tyr Asp Phe Leu Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly
    210                 215                 220                 
Ile Arg Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg
225                 230                 235                 240 
Ala Leu Tyr Pro Ser Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly
                245                 250                 255     
Lys Ser Gln Met Tyr Val Gln His Arg Val Ala Glu Ala Phe Arg Val
            260                 265                 270         
Ala Val Ala Ala Gly Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln
        275                 280                 285             
Ile Phe Tyr Asp Thr Thr Asn His Phe Leu Pro Leu Asp Glu Leu Glu
    290                 295                 300                 
His Ser Leu Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu
305                 310                 315                 320 
Trp Val Ser Trp Glu Asn Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile
                325                 330                 335     
Lys Glu Tyr Met Asp Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr
            340                 345                 350         
Ser Gly Ala Leu Leu Cys Ser Gln Ala Leu Cys Ser Gly His Gly Arg
        355                 360                 365             
Cys Val Arg Arg Thr Ser His Pro Lys Ala Leu Leu Leu Leu Asn Pro
    370                 375                 380                 
Ala Ser Phe Ser Ile Gln Leu Thr Pro Gly Gly Gly Pro Leu Ser Leu
385                 390                 395                 400 
Arg Gly Ala Leu Ser Leu Glu Asp Gln Ala Gln Met Ala Val Glu Phe
                405                 410                 415     
Lys Cys Arg Cys Tyr Pro Gly Trp Gln Ala Pro Trp Cys Glu Arg Lys
            420                 425                 430         
Ser Met Trp
        435 


<210> 263
<211> 473
<212> PRT
<213> Homo sapiens

<220> 
<223> Hyaluronidase-2 [Precursor]

<400> 263
Met Arg Ala Gly Pro Gly Pro Thr Val Thr Leu Ala Leu Val Leu Ala
 1               5                  10                  15      
Val Ala Trp Ala Met Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr
            20                  25                  30          
Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly
        35                  40                  45              
Pro Arg Leu Lys Val Pro Leu Asp Leu Asn Ala Phe Asp Val Gln Ala
    50                  55                  60                  
Ser Pro Asn Glu Gly Phe Val Asn Gln Asn Ile Thr Ile Phe Tyr Arg
65                  70                  75                  80  
Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ser Ala Gly Arg Ser Val
                85                  90                  95      
His Gly Gly Val Pro Gln Asn Val Ser Leu Trp Ala His Arg Lys Met
            100                 105                 110         
Leu Gln Lys Arg Val Glu His Tyr Ile Arg Thr Gln Glu Ser Ala Gly
        115                 120                 125             
Leu Ala Val Ile Asp Trp Glu Asp Trp Arg Pro Val Trp Val Arg Asn
    130                 135                 140                 
Trp Gln Asp Lys Asp Val Tyr Arg Arg Leu Ser Arg Gln Leu Val Ala
145                 150                 155                 160 
Ser Arg His Pro Asp Trp Pro Pro Asp Arg Ile Val Lys Gln Ala Gln
                165                 170                 175     
Tyr Glu Phe Glu Phe Ala Ala Gln Gln Phe Met Leu Glu Thr Leu Arg
            180                 185                 190         
Tyr Val Lys Ala Val Arg Pro Arg His Leu Trp Gly Phe Tyr Leu Phe
        195                 200                 205             
Pro Asp Cys Tyr Asn His Asp Tyr Val Gln Asn Trp Glu Ser Tyr Thr
    210                 215                 220                 
Gly Arg Cys Pro Asp Val Glu Val Ala Arg Asn Asp Gln Leu Ala Trp
225                 230                 235                 240 
Leu Trp Ala Glu Ser Thr Ala Leu Phe Pro Ser Val Tyr Leu Asp Glu
                245                 250                 255     
Thr Leu Ala Ser Ser Arg His Gly Arg Asn Phe Val Ser Phe Arg Val
            260                 265                 270         
Gln Glu Ala Leu Arg Val Ala Arg Thr His His Ala Asn His Ala Leu
        275                 280                 285             
Pro Val Tyr Val Phe Thr Arg Pro Thr Tyr Ser Arg Arg Leu Thr Gly
    290                 295                 300                 
Leu Ser Glu Met Asp Leu Ile Ser Thr Ile Gly Glu Ser Ala Ala Leu
305                 310                 315                 320 
Gly Ala Ala Gly Val Ile Leu Trp Gly Asp Ala Gly Tyr Thr Thr Ser
                325                 330                 335     
Thr Glu Thr Cys Gln Tyr Leu Lys Asp Tyr Leu Thr Arg Leu Leu Val
            340                 345                 350         
Pro Tyr Val Val Asn Val Ser Trp Ala Thr Gln Tyr Cys Ser Arg Ala
        355                 360                 365             
Gln Cys His Gly His Gly Arg Cys Val Arg Arg Asn Pro Ser Ala Ser
    370                 375                 380                 
Thr Phe Leu His Leu Ser Thr Asn Ser Phe Arg Leu Val Pro Gly His
385                 390                 395                 400 
Ala Pro Gly Glu Pro Gln Leu Arg Pro Val Gly Glu Leu Ser Trp Ala
                405                 410                 415     
Asp Ile Asp His Leu Gln Thr His Phe Arg Cys Gln Cys Tyr Leu Gly
            420                 425                 430         
Trp Ser Gly Glu Gln Cys Gln Trp Asp His Arg Gln Ala Ala Gly Gly
        435                 440                 445             
Ala Ser Glu Ala Trp Ala Gly Ser His Leu Thr Ser Leu Leu Ala Leu
    450                 455                 460                 
Ala Ala Leu Ala Phe Thr Trp Thr Leu
465                 470             



<210> 264
<211> 417
<212> PRT
<213> Homo sapiens

<220> 
<223> Hyaluronidase-3 [Precursor]

<400> 264
Met Thr Thr Gln Leu Gly Pro Ala Leu Val Leu Gly Val Ala Leu Cys
 1               5                  10                  15      
Leu Gly Cys Gly Gln Pro Leu Pro Gln Val Pro Glu Arg Pro Phe Ser
            20                  25                  30          
Val Leu Trp Asn Val Pro Ser Ala His Cys Glu Ala Arg Phe Gly Val
        35                  40                  45              
His Leu Pro Leu Asn Ala Leu Gly Ile Ile Ala Asn Arg Gly Gln His
    50                  55                  60                  
Phe His Gly Gln Asn Met Thr Ile Phe Tyr Lys Asn Gln Leu Gly Leu
65                  70                  75                  80  
Tyr Pro Tyr Phe Gly Pro Arg Gly Thr Ala His Asn Gly Gly Ile Pro
                85                  90                  95      
Gln Ala Leu Pro Leu Asp Arg His Leu Ala Leu Ala Ala Tyr Gln Ile
            100                 105                 110         
His His Ser Leu Arg Pro Gly Phe Ala Gly Pro Ala Val Leu Asp Trp
        115                 120                 125             
Glu Glu Trp Cys Pro Leu Trp Ala Gly Asn Trp Gly Arg Arg Arg Ala
    130                 135                 140                 
Tyr Gln Ala Ala Ser Trp Ala Trp Ala Gln Gln Val Phe Pro Asp Leu
145                 150                 155                 160 
Asp Pro Gln Glu Gln Leu Tyr Lys Ala Tyr Thr Gly Phe Glu Gln Ala
                165                 170                 175     
Ala Arg Ala Leu Met Glu Asp Thr Leu Arg Val Ala Gln Ala Leu Arg
            180                 185                 190         
Pro His Gly Leu Trp Gly Phe Tyr His Tyr Pro Ala Cys Gly Asn Gly
        195                 200                 205             
Trp His Ser Met Ala Ser Asn Tyr Thr Gly Arg Cys His Ala Ala Thr
    210                 215                 220                 
Leu Ala Arg Asn Thr Gln Leu His Trp Leu Trp Ala Ala Ser Ser Ala
225                 230                 235                 240 
Leu Phe Pro Ser Ile Tyr Leu Pro Pro Arg Leu Pro Pro Ala His His
                245                 250                 255     
Gln Ala Phe Val Arg His Arg Leu Glu Glu Ala Phe Arg Val Ala Leu
            260                 265                 270         
Val Gly His Arg His Pro Leu Pro Val Leu Ala Tyr Val Arg Leu Thr
        275                 280                 285             
His Arg Arg Ser Gly Arg Phe Leu Ser Gln Asp Asp Leu Val Gln Ser
    290                 295                 300                 
Ile Gly Val Ser Ala Ala Leu Gly Ala Ala Gly Val Val Leu Trp Gly
305                 310                 315                 320 
Asp Leu Ser Leu Ser Ser Ser Glu Glu Glu Cys Trp His Leu His Asp
                325                 330                 335     
Tyr Leu Val Asp Thr Leu Gly Pro Tyr Val Ile Asn Val Thr Arg Ala
            340                 345                 350         
Ala Met Ala Cys Ser His Gln Arg Cys His Gly His Gly Arg Cys Ala
        355                 360                 365             
Arg Arg Asp Pro Gly Gln Met Glu Ala Phe Leu His Leu Trp Pro Asp
    370                 375                 380                 
Gly Ser Leu Gly Asp Trp Lys Ser Phe Ser Cys His Cys Tyr Trp Gly
385                 390                 395                 400 
Trp Ala Gly Pro Thr Cys Gln Glu Pro Arg Pro Gly Pro Lys Glu Ala
                405                 410                 415     
Val
    


<210> 265
<211> 481
<212> PRT
<213> Homo sapiens

<220> 
<223> Hyaluronidase-4

<400> 265
Met Lys Val Leu Ser Glu Gly Gln Leu Lys Leu Cys Val Val Gln Pro
 1               5                  10                  15      
Val His Leu Thr Ser Trp Leu Leu Ile Phe Phe Ile Leu Lys Ser Ile
            20                  25                  30          
Ser Cys Leu Lys Pro Ala Arg Leu Pro Ile Tyr Gln Arg Lys Pro Phe
        35                  40                  45              
Ile Ala Ala Trp Asn Ala Pro Thr Asp Gln Cys Leu Ile Lys Tyr Asn
    50                  55                  60                  
Leu Arg Leu Asn Leu Lys Met Phe Pro Val Ile Gly Ser Pro Leu Ala
65                  70                  75                  80  
Lys Ala Arg Gly Gln Asn Val Thr Ile Phe Tyr Val Asn Arg Leu Gly
                85                  90                  95      
Tyr Tyr Pro Trp Tyr Thr Ser Gln Gly Val Pro Ile Asn Gly Gly Leu
            100                 105                 110         
Pro Gln Asn Ile Ser Leu Gln Val His Leu Glu Lys Ala Asp Gln Asp
        115                 120                 125             
Ile Asn Tyr Tyr Ile Pro Ala Glu Asp Phe Ser Gly Leu Ala Val Ile
    130                 135                 140                 
Asp Trp Glu Tyr Trp Arg Pro Gln Trp Ala Arg Asn Trp Asn Ser Lys
145                 150                 155                 160 
Asp Val Tyr Arg Gln Lys Ser Arg Lys Leu Ile Ser Asp Met Gly Lys
                165                 170                 175     
Asn Val Ser Ala Thr Asp Ile Glu Tyr Leu Ala Lys Val Thr Phe Glu
            180                 185                 190         
Glu Ser Ala Lys Ala Phe Met Lys Glu Thr Ile Lys Leu Gly Ile Lys
        195                 200                 205             
Ser Arg Pro Lys Gly Leu Trp Gly Tyr Tyr Leu Tyr Pro Asp Cys His
    210                 215                 220                 
Asn Tyr Asn Val Tyr Ala Pro Asn Tyr Ser Gly Ser Cys Pro Glu Asp
225                 230                 235                 240 
Glu Val Leu Arg Asn Asn Glu Leu Ser Trp Leu Trp Asn Ser Ser Ala
                245                 250                 255     
Ala Leu Tyr Pro Ser Ile Gly Val Trp Lys Ser Leu Gly Asp Ser Glu
            260                 265                 270         
Asn Ile Leu Arg Phe Ser Lys Phe Arg Val His Glu Ser Met Arg Ile
        275                 280                 285             
Ser Thr Met Thr Ser His Asp Tyr Ala Leu Pro Val Phe Val Tyr Thr
    290                 295                 300                 
Arg Leu Gly Tyr Arg Asp Glu Pro Leu Phe Phe Leu Ser Lys Gln Asp
305                 310                 315                 320 
Leu Val Ser Thr Ile Gly Glu Ser Ala Ala Leu Gly Ala Ala Gly Ile
                325                 330                 335     
Val Ile Trp Gly Asp Met Asn Leu Thr Ala Ser Lys Ala Asn Cys Thr
            340                 345                 350         
Lys Val Lys Gln Phe Val Ser Ser Asp Leu Gly Ser Tyr Ile Ala Asn
        355                 360                 365             
Val Thr Arg Ala Ala Glu Val Cys Ser Leu His Leu Cys Arg Asn Asn
    370                 375                 380                 
Gly Arg Cys Ile Arg Lys Met Trp Asn Ala Pro Ser Tyr Leu His Leu
385                 390                 395                 400 
Asn Pro Ala Ser Tyr His Ile Glu Ala Ser Glu Asp Gly Glu Phe Thr
                405                 410                 415     
Val Lys Gly Lys Ala Ser Asp Thr Asp Leu Ala Val Met Ala Asp Thr
            420                 425                 430         

Phe Ser Cys His Cys Tyr Gln Gly Tyr Glu Gly Ala Asp Cys Arg Glu
        435                 440                 445             
Ile Lys Thr Ala Asp Gly Cys Ser Gly Val Ser Pro Ser Pro Gly Ser
    450                 455                 460                 
Leu Met Thr Leu Cys Leu Leu Leu Leu Ala Ser Tyr Arg Ser Ile Gln
465                 470                 475                 480 
Leu

<210> 266
<211> 553
<212> PRT
<213> Bos taurus

<220> 
<223> PH20

<400> 266
Met Arg Met Leu Arg Arg His His Ile Ser Phe Arg Ser Phe Ala Gly
 1               5                  10                  15      
Ser Ser Gly Thr Pro Gln Ala Val Phe Thr Phe Leu Leu Leu Pro Cys
            20                  25                  30          
Cys Leu Ala Leu Asp Phe Arg Ala Pro Pro Leu Ile Ser Asn Thr Ser
        35                  40                  45              
Phe Leu Trp Ala Trp Asn Ala Pro Val Glu Arg Cys Val Asn Arg Arg
    50                  55                  60                  
Phe Gln Leu Pro Pro Asp Leu Arg Leu Phe Ser Val Lys Gly Ser Pro
65                  70                  75                  80  
Gln Lys Ser Ala Thr Gly Gln Phe Ile Thr Leu Phe Tyr Ala Asp Arg
                85                  90                  95      
Leu Gly Tyr Tyr Pro His Ile Asp Glu Lys Thr Gly Lys Thr Val Phe
            100                 105                 110         
Gly Gly Ile Pro Gln Leu Gly Asn Leu Lys Ser His Met Glu Lys Ala
        115                 120                 125             
Lys Asn Asp Ile Ala Tyr Tyr Ile Pro Asn Asp Ser Val Gly Leu Ala
    130                 135                 140                 
Val Ile Asp Trp Glu Asn Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys
145                 150                 155                 160 
Pro Lys Asp Val Tyr Arg Asp Glu Ser Val Glu Leu Val Leu Gln Lys
                165                 170                 175     
Asn Pro Gln Leu Ser Phe Pro Glu Ala Ser Lys Ile Ala Lys Val Asp
            180                 185                 190         
Phe Glu Thr Ala Gly Lys Ser Phe Met Gln Glu Thr Leu Lys Leu Gly
        195                 200                 205             
Lys Leu Leu Arg Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp
    210                 215                 220                 
Cys Tyr Asn His Asn His Asn Gln Pro Thr Tyr Asn Gly Asn Cys Pro
225                 230                 235                 240 
Asp Val Glu Lys Arg Arg Asn Asp Asp Leu Glu Trp Leu Trp Lys Glu
                245                 250                 255     
Ser Thr Ala Leu Phe Pro Ser Val Tyr Leu Asn Ile Arg Leu Lys Ser
            260                 265                 270         
Thr Gln Asn Ala Ala Leu Tyr Val Arg Asn Arg Val Gln Glu Ala Ile
        275                 280                 285             
Arg Leu Ser Lys Ile Ala Ser Val Glu Ser Pro Leu Pro Val Phe Val
    290                 295                 300                 
Tyr Ala Arg Pro Val Phe Thr Asp Gly Ser Ser Thr Tyr Leu Ser Gln
305                 310                 315                 320 
Gly Asp Leu Val Asn Ser Val Gly Glu Ile Val Ser Leu Gly Ala Ser
                325                 330                 335     
Gly Ile Ile Met Trp Gly Ser Leu Asn Leu Ser Leu Ser Met Gln Ser
            340                 345                 350         
Cys Met Asn Leu Gly Thr Tyr Leu Asn Thr Thr Leu Asn Pro Tyr Ile
        355                 360                 365             
Ile Asn Val Thr Leu Ala Ala Lys Met Cys Ser Gln Val Leu Cys His
    370                 375                 380                 
Asn Glu Gly Val Cys Thr Arg Lys His Trp Asn Ser Ser Asp Tyr Leu
385                 390                 395                 400 
His Leu Asn Pro Met Asn Phe Ala Ile Gln Thr Gly Glu Gly Gly Lys
                405                 410                 415     
Tyr Thr Val Pro Gly Thr Val Thr Leu Glu Asp Leu Gln Lys Phe Ser
            420                 425                 430         
Asp Thr Phe Tyr Cys Ser Cys Tyr Ala Asn Ile His Cys Lys Lys Arg
        435                 440                 445             
Val Asp Ile Lys Asn Val His Ser Val Asn Val Cys Met Ala Glu Asp
    450                 455                 460                 
Ile Cys Ile Asp Ser Pro Val Lys Leu Gln Pro Ser Asp His Ser Ser
465                 470                 475                 480 
Ser Gln Glu Ala Ser Thr Thr Thr Phe Ser Ser Ile Ser Pro Ser Thr
                485                 490                 495     
Thr Thr Ala Thr Val Ser Pro Cys Thr Pro Glu Lys His Ser Pro Glu
            500                 505                 510         
Cys Leu Lys Val Arg Cys Ser Glu Val Ile Pro Asn Val Thr Gln Lys
        515                 520                 525             
Ala Cys Gln Ser Val Lys Leu Lys Asn Ile Ser Tyr Gln Ser Pro Ile
    530                 535                 540                 
Gln Asn Ile Lys Asn Gln Thr Thr Tyr
545                 550             

<210> 267
<211> 114
<212> PRT
<213> Ovis aries

<220> 
<223> PH20 partial sequence

<400> 267
Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Leu Ser Lys Ile
 1               5                  10                  15      
Ala Ser Val Glu Ser Pro Leu Pro Val Phe Val Tyr His Arg Pro Val
            20                  25                  30          
Phe Thr Asp Gly Ser Ser Thr Tyr Leu Ser Gln Gly Asp Leu Val Asn
        35                  40                  45              
Ser Val Gly Glu Ile Val Ala Leu Gly Ala Ser Gly Ile Ile Met Trp
    50                  55                  60                  
Gly Ser Leu Asn Leu Ser Leu Thr Met Gln Ser Cys Met Asn Leu Gly
65                  70                  75                  80  
Asn Tyr Leu Asn Thr Thr Leu Asn Pro Tyr Ile Ile Asn Val Thr Leu
                85                  90                  95      
Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln Gly Val Cys
            100                 105                 110         
Ile Arg
        
<210> 268
<211> 1446
<212> DNA
<213> Homo sapiens

<220> 
<223> DNA encoding soluble rHuPH20 "precursor"
      

<400> 268
atgggagtgc taaaattcaa gcacatcttt ttcagaagct ttgttaaatc aagtggagta 60
tcccagatag ttttcacctt ccttctgatt ccatgttgct tgactctgaa tttcagagca 120
cctcctgtta ttccaaatgt gcctttcctc tgggcctgga atgccccaag tgaattttgt 180
cttggaaaat ttgatgagcc actagatatg agcctcttct ctttcatagg aagcccccga 240
ataaacgcca ccgggcaagg tgttacaata ttttatgttg atagacttgg ctactatcct 300
tacatagatt caatcacagg agtaactgtg aatggaggaa tcccccagaa gatttcctta 360
caagaccatc tggacaaagc taagaaagac attacatttt atatgccagt agacaatttg 420
ggaatggctg ttattgactg ggaagaatgg agacccactt gggcaagaaa ctggaaacct 480
aaagatgttt acaagaatag gtctattgaa ttggttcagc aacaaaatgt acaacttagt 540
ctcacagagg ccactgagaa agcaaaacaa gaatttgaaa aggcagggaa ggatttcctg 600
gtagagacta taaaattggg aaaattactt cggccaaatc acttgtgggg ttattatctt 660
tttccggatt gttacaacca tcactataag aaacccggtt acaatggaag ttgcttcaat 720
gtagaaataa aaagaaatga tgatctcagc tggttgtgga atgaaagcac tgctctttac 780
ccatccattt atttgaacac tcagcagtct cctgtagctg ctacactcta tgtgcgcaat 840
cgagttcggg aagccatcag agtttccaaa atacctgatg caaaaagtcc acttccggtt 900
tttgcatata cccgcatagt ttttactgat caagttttga aattcctttc tcaagatgaa 960
cttgtgtata catttggcga aactgttgct ctgggtgctt ctggaattgt aatatgggga 1020
accctcagta taatgcgaag tatgaaatct tgcttgctcc tagacaatta catggagact 1080
atactgaatc cttacataat caacgtcaca ctagcagcca aaatgtgtag ccaagtgctt 1140
tgccaggagc aaggagtgtg tataaggaaa aactggaatt caagtgacta tcttcacctc 1200
aacccagata attttgctat tcaacttgag aaaggtggaa agttcacagt acgtggaaaa 1260
ccgacacttg aagacctgga gcaattttct gaaaaatttt attgcagctg ttatagcacc 1320
ttgagttgta aggagaaagc tgatgtaaaa gacactgatg ctgttgatgt gtgtattgct 1380
gatggtgtct gtatagatgc ttttctaaaa cctcccatgg agacagaaga acctcaaatt 1440
ttctac                                                            1446

<210> 269
<211> 509
<212> PRT
<213> Homo sapiens

<220> 
<223> PH20 variant P48A

<400> 269
Met Gly Val Leu Lys Phe Lys His Ile Phe Phe Arg Ser Phe Val Lys
 1               5                  10                  15      
Ser Ser Gly Val Ser Gln Ile Val Phe Thr Phe Leu Leu Ile Pro Cys
            20                  25                  30          
Cys Leu Thr Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Ala
        35                  40                  45              
Phe Leu Trp Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe
    50                  55                  60                  
Asp Glu Pro Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg
65                  70                  75                  80  
Ile Asn Ala Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu
                85                  90                  95      
Gly Tyr Tyr Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly
            100                 105                 110         
Gly Ile Pro Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys
        115                 120                 125             
Lys Asp Ile Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val
    130                 135                 140                 
Ile Asp Trp Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro
145                 150                 155                 160 
Lys Asp Val Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn
                165                 170                 175     
Val Gln Leu Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe
            180                 185                 190         
Glu Lys Ala Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys
        195                 200                 205             
Leu Leu Arg Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys
    210                 215                 220                 
Tyr Asn His His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn
225                 230                 235                 240 
Val Glu Ile Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser
                245                 250                 255     
Thr Ala Leu Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val
            260                 265                 270         
Ala Ala Thr Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val
        275                 280                 285             
Ser Lys Ile Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr
    290                 295                 300                 
Arg Ile Val Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu
305                 310                 315                 320 
Leu Val Tyr Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile
                325                 330                 335     
Val Ile Trp Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu
            340                 345                 350         
Leu Leu Asp Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn
        355                 360                 365             
Val Thr Leu Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln
    370                 375                 380                 
Gly Val Cys Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu
385                 390                 395                 400 
Asn Pro Asp Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Phe Thr
                405                 410                 415     
Val Arg Gly Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys
            420                 425                 430         
Phe Tyr Cys Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp
        435                 440                 445             
Val Lys Asp Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys
    450                 455                 460                 
Ile Asp Ala Phe Leu Lys Pro Pro Met Glu Thr Glu Glu Pro Gln Ile
465                 470                 475                 480 
Phe Tyr Asn Ala Ser Pro Ser Thr Leu Ser Ala Thr Met Phe Ile Val
                485                 490                 495     
Ser Ile Leu Phe Leu Ile Ile Ser Ser Val Ala Ser Leu
            500                 505                 


<210> 270
<211> 509
<212> PRT
<213> Homo sapiens

<220> 
<223> precursor PH20 variant L499W
      

<400> 270
Met Gly Val Leu Lys Phe Lys His Ile Phe Phe Arg Ser Phe Val Lys
 1               5                  10                  15      
Ser Ser Gly Val Ser Gln Ile Val Phe Thr Phe Leu Leu Ile Pro Cys
            20                  25                  30          
Cys Leu Thr Leu Asn Phe Arg Ala Pro Pro Val Ile Pro Asn Val Pro
        35                  40                  45              
Phe Leu Trp Ala Trp Asn Ala Pro Ser Glu Phe Cys Leu Gly Lys Phe
    50                  55                  60                  
Asp Glu Pro Leu Asp Met Ser Leu Phe Ser Phe Ile Gly Ser Pro Arg
65                  70                  75                  80  
Ile Asn Ala Thr Gly Gln Gly Val Thr Ile Phe Tyr Val Asp Arg Leu
                85                  90                  95      
Gly Tyr Tyr Pro Tyr Ile Asp Ser Ile Thr Gly Val Thr Val Asn Gly
            100                 105                 110         
Gly Ile Pro Gln Lys Ile Ser Leu Gln Asp His Leu Asp Lys Ala Lys
        115                 120                 125             
Lys Asp Ile Thr Phe Tyr Met Pro Val Asp Asn Leu Gly Met Ala Val
    130                 135                 140                 
Ile Asp Trp Glu Glu Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro
145                 150                 155                 160 
Lys Asp Val Tyr Lys Asn Arg Ser Ile Glu Leu Val Gln Gln Gln Asn
                165                 170                 175     
Val Gln Leu Ser Leu Thr Glu Ala Thr Glu Lys Ala Lys Gln Glu Phe
            180                 185                 190         
Glu Lys Ala Gly Lys Asp Phe Leu Val Glu Thr Ile Lys Leu Gly Lys
        195                 200                 205             
Leu Leu Arg Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys
    210                 215                 220                 
Tyr Asn His His Tyr Lys Lys Pro Gly Tyr Asn Gly Ser Cys Phe Asn
225                 230                 235                 240 
Val Glu Ile Lys Arg Asn Asp Asp Leu Ser Trp Leu Trp Asn Glu Ser
                245                 250                 255     
Thr Ala Leu Tyr Pro Ser Ile Tyr Leu Asn Thr Gln Gln Ser Pro Val
            260                 265                 270         
Ala Ala Thr Leu Tyr Val Arg Asn Arg Val Arg Glu Ala Ile Arg Val
        275                 280                 285             
Ser Lys Ile Pro Asp Ala Lys Ser Pro Leu Pro Val Phe Ala Tyr Thr
    290                 295                 300                 
Arg Ile Val Phe Thr Asp Gln Val Leu Lys Phe Leu Ser Gln Asp Glu
305                 310                 315                 320 
Leu Val Tyr Thr Phe Gly Glu Thr Val Ala Leu Gly Ala Ser Gly Ile
                325                 330                 335     
Val Ile Trp Gly Thr Leu Ser Ile Met Arg Ser Met Lys Ser Cys Leu
            340                 345                 350         
Leu Leu Asp Asn Tyr Met Glu Thr Ile Leu Asn Pro Tyr Ile Ile Asn
        355                 360                 365             
Val Thr Leu Ala Ala Lys Met Cys Ser Gln Val Leu Cys Gln Glu Gln
    370                 375                 380                 
Gly Val Cys Ile Arg Lys Asn Trp Asn Ser Ser Asp Tyr Leu His Leu
385                 390                 395                 400 
Asn Pro Asp Asn Phe Ala Ile Gln Leu Glu Lys Gly Gly Lys Phe Thr
                405                 410                 415     
Val Arg Gly Lys Pro Thr Leu Glu Asp Leu Glu Gln Phe Ser Glu Lys
            420                 425                 430         
Phe Tyr Cys Ser Cys Tyr Ser Thr Leu Ser Cys Lys Glu Lys Ala Asp
        435                 440                 445             
Val Lys Asp Thr Asp Ala Val Asp Val Cys Ile Ala Asp Gly Val Cys
    450                 455                 460                 
Ile Asp Ala Phe Leu Lys Pro Pro Met Glu Thr Glu Glu Pro Gln Ile
465                 470                 475                 480 
Phe Tyr Asn Ala Ser Pro Ser Thr Leu Ser Ala Thr Met Phe Ile Val
                485                 490                 495     
Ser Ile Trp Phe Leu Ile Ile Ser Ser Val Ala Ser Leu
            500                 505                 


<210> 271
<211> 520
<212> PRT
<213> Ovis aries

<400> 271
Leu Asp Phe Pro Ala Pro Pro Leu Ile Ser Asn Thr Ser Phe Leu Trp
 1               5                  10                  15      
Ala Trp Asn Ala Pro Ala Glu Arg Cys Val Lys Ile Phe Lys Leu Pro
            20                  25                  30          
Pro Asp Leu Arg Leu Phe Ser Val Lys Gly Ser Pro Gln Lys Ser Ala
        35                  40                  45              
Thr Gly Gln Phe Ile Thr Leu Phe Tyr Ala Asp Arg Leu Gly Tyr Tyr
    50                  55                  60                  
Pro His Ile Asp Glu Lys Thr Gly Asn Thr Val Tyr Gly Gly Ile Pro
65                  70                  75                  80  
Gln Leu Gly Asn Leu Lys Asn His Leu Glu Lys Ala Lys Lys Asp Ile
                85                  90                  95      
Ala Tyr Tyr Ile Pro Asn Asp Ser Val Gly Leu Ala Val Ile Asp Trp
            100                 105                 110         
Glu Asn Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro Lys Asp Val
        115                 120                 125             
Tyr Arg Asp Glu Ser Val Glu Leu Val Leu Gln Lys Asn Pro Gln Leu
    130                 135                 140                 
Ser Phe Pro Glu Ala Ser Lys Ile Ala Lys Val Asp Phe Glu Thr Ala
145                 150                 155                 160 
Gly Lys Ser Phe Met Gln Glu Thr Leu Lys Leu Gly Lys Leu Leu Arg
                165                 170                 175     
Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys Tyr Asn His
            180                 185                 190         
Asn Tyr Asn Gln Pro Thr Tyr Asn Gly Asn Cys Ser Asp Leu Glu Lys
        195                 200                 205             
Arg Arg Asn Asp Asp Leu Asp Trp Leu Trp Lys Glu Ser Thr Ala Leu
    210                 215                 220                 
Phe Pro Ser Val Tyr Leu Asn Ile Lys Leu Lys Ser Thr Pro Lys Ala
225                 230                 235                 240 
Ala Phe Tyr Val Arg Asn Arg Val Gln Glu Ala Ile Arg Leu Ser Lys
                245                 250                 255     
Ile Ala Ser Val Glu Ser Pro Leu Pro Val Phe Val Tyr His Arg Pro
            260                 265                 270         
Val Phe Thr Asp Gly Ser Ser Thr Tyr Leu Ser Gln Gly Asp Leu Val
        275                 280                 285             
Asn Ser Val Gly Glu Ile Val Ala Leu Gly Ala Ser Gly Ile Ile Met
    290                 295                 300                 
Trp Gly Ser Leu Asn Leu Ser Leu Thr Met Gln Ser Cys Met Asn Leu
305                 310                 315                 320 
Gly Asn Tyr Asn Thr Thr Leu Asn Pro Tyr Ile Ile Asn Val Thr Leu
                325                 330                 335     
Ala Ala Lys Met Cys Ser Gln Val Leu Cys His Asp Glu Gly Val Cys
            340                 345                 350         
Thr Arg Lys Gln Trp Asn Ser Ser Asp Tyr Leu His Leu Asn Pro Ile
        355                 360                 365             
Met Asn Phe Ala Ile Gln Thr Gly Lys Gly Gly Lys Tyr Thr Val Pro
    370                 375                 380                 
Gly Lys Val Thr Leu Glu Asp Leu Gln Thr Phe Ser Asp Lys Phe Tyr
385                 390                 395                 400 
Cys Ser Cys Tyr Ala Asn Ile Asn Cys Lys Lys Arg Val Asp Ile Lys
                405                 410                 415     
Asn Val His Ser Val Asn Val Cys Met Ala Glu Asp Ile Cys Ile Glu
            420                 425                 430         
Gly Pro Val Lys Leu Gln Pro Ser Asp His Ser Ser Ser Gln Asn Glu
        435                 440                 445             
Ala Ser Thr Thr Thr Val Ser Ser Ile Ser Pro Ser Thr Thr Ala Thr
    450                 455                 460                 
Thr Val Val Ser Pro Cys Thr Pro Glu Lys Gln Ser Pro Glu Cys Leu
465                 470                 475                 480 
Lys Val Arg Cys Leu Glu Ala Ile Ala Asn Val Thr Gln Thr Gly Cys
                485                 490                 495     
Gln Gly Val Lys Trp Lys Asn Thr Ser Ser Gln Ser Gln Ser Ser Ile
            500                 505                 510         
Gln Asn Ile Lys Asn Gln Thr Thr
        515                 520 


<210> 272
<211> 474
<212> PRT
<213> Bos taurus

<220> 
<223> PH20

<400> 272
Met Gly Met Phe Arg Arg His His Ile Ser Phe Arg Ser Phe Ala Gly
 1               5                  10                  15      
Ser Ser Gly Thr Pro Gln Ala Val Phe Thr Phe Leu Leu Leu Pro Cys
            20                  25                  30          
Cys Leu Ala Leu Asp Phe Arg Ala Pro Pro Leu Ile Ser Asn Thr Ser
        35                  40                  45              
Phe Leu Trp Ala Trp Asn Ala Pro Val Glu Arg Cys Val Asn Arg Arg
    50                  55                  60                  
Phe Gln Leu Pro Pro Asp Leu Arg Leu Phe Ser Val Lys Gly Ser Pro
65                  70                  75                  80  
Gln Lys Ser Ala Thr Gly Gln Phe Ile Thr Leu Phe Tyr Ala Asp Arg
                85                  90                  95      
Leu Gly Tyr Tyr Pro His Ile Asp Glu Lys Thr Gly Lys Thr Val Phe
            100                 105                 110         
Gly Gly Ile Pro Gln Leu Gly Asn Leu Lys Ser His Leu Glu Lys Ala
        115                 120                 125             
Lys Asn Asp Ile Ala Tyr Tyr Ile Pro Asn Asp Ser Val Gly Leu Ala
    130                 135                 140                 
Val Ile Asp Trp Glu Asn Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys
145                 150                 155                 160 
Pro Lys Asp Val Tyr Arg Asp Glu Ser Val Glu Leu Val Leu Gln Lys
                165                 170                 175     
Asn Pro Gln Leu Ser Phe Pro Glu Ala Ser Lys Ile Ala Lys Val Asp
            180                 185                 190         
Phe Glu Thr Ala Gly Lys Ser Phe Met Gln Glu Thr Leu Lys Leu Gly
        195                 200                 205             
Lys Leu Leu Arg Pro Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp
    210                 215                 220                 
Cys Tyr Asn His Asn His Asn Gln Pro Thr Tyr Asn Gly Asn Cys Pro
225                 230                 235                 240 
Asp Val Glu Lys Arg Arg Asn Asp Asp Leu Glu Trp Leu Trp Lys Glu
                245                 250                 255     
Ser Thr Ala Leu Phe Pro Ser Val Tyr Leu Asn Ile Arg Leu Lys Ser
            260                 265                 270         
Thr Gln Asn Ala Ala Leu Tyr Val Arg Asn Arg Val Gln Glu Ala Ile
        275                 280                 285             
Arg Leu Ser Lys Ile Ala Ser Val Glu Ser Pro Leu Pro Val Phe Val
    290                 295                 300                 
Tyr Ala Arg Pro Val Phe Thr Asp Gly Ser Ser Thr Tyr Leu Ser Gln
305                 310                 315                 320 
Gly Asp Leu Val Asn Ser Val Gly Glu Ile Val Ser Leu Gly Ala Ser

                325                 330                 335     
Gly Ile Ile Met Trp Gly Ser Leu Asn Leu Ser Leu Ser Val Gln Ser
            340                 345                 350         
Cys Met Asn Leu Gly Thr Tyr Leu Asn Thr Thr Leu Asn Pro Tyr Ile
        355                 360                 365             
Ile Asn Val Thr Leu Ala Ala Lys Met Cys Ser Gln Val Leu Cys His
    370                 375                 380                 
Asp Gly Gly Val Cys Thr Arg Lys His Trp Asn Ser Ser Asp Tyr Leu
385                 390                 395                 400 
His Leu Asn Pro Met Asn Phe Ala Ile Gln Thr Gly Glu Gly Gly Lys
                405                 410                 415     
Tyr Thr Val Pro Gly Thr Leu Thr Leu Glu Asp Leu Gln Lys Phe Ser
            420                 425                 430         
Asp Thr Phe Tyr Cys Ser Cys Tyr Ser Asn Leu Ser Cys Lys Lys Arg
        435                 440                 445             
Val Asp Ile Lys Asn Val His Ser Val Asp Val Cys Met Ala Glu Asp
    450                 455                 460                 
Val Cys Ile Asp Ala Phe Leu Lys Pro Pro
465                 470                 

<210> 273
<211> 517
<212> PRT
<213> Ovis aries

<400> 273
Asp Phe Arg Ala Pro Pro Leu Ile Ser Asn Thr Ser Phe Leu Trp Ala
 1               5                  10                  15      
Trp Asn Ala Pro Ala Glu Arg Cys Ile Lys Ile Phe Lys Leu Pro Pro
            20                  25                  30          
Asp Leu Arg Leu Phe Ser Val Lys Gly Ser Pro Gln Lys Ser Ala Thr
        35                  40                  45              
Gly Gln Phe Ile Thr Leu Phe Tyr Ala Asp Arg Leu Gly Tyr Tyr Pro
    50                  55                  60                  
His Ile Asp Glu Lys Thr Gly Asn Thr Val Tyr Gly Gly Ile Pro Gln
65                  70                  75                  80  
Leu Gly Asn Leu Lys Asn His Leu Glu Lys Ala Lys Lys Asp Ile Ala
                85                  90                  95      
Tyr Tyr Ile Pro Asn Asp Ser Val Gly Leu Ala Val Ile Asp Trp Glu
            100                 105                 110         
Asn Trp Arg Pro Thr Trp Ala Arg Asn Trp Lys Pro Lys Asp Val Tyr
        115                 120                 125             
Arg Asp Glu Ser Val Glu Leu Val Leu Gln Lys Asn Pro Gln Leu Ser
    130                 135                 140                 
Phe Pro Glu Ala Ser Lys Ile Ala Lys Val Asp Phe Glu Thr Ala Gly
145                 150                 155                 160 
Lys Ser Phe Met Gln Glu Thr Leu Lys Leu Gly Lys Leu Leu Arg Pro
                165                 170                 175     
Asn His Leu Trp Gly Tyr Tyr Leu Phe Pro Asp Cys Tyr Asn His Asn
            180                 185                 190         
Tyr Asn Gln Pro Thr Tyr Asn Gly Asn Cys Ser Asp Leu Glu Lys Arg
        195                 200                 205             
Arg Asn Asp Asp Leu Asp Trp Leu Trp Lys Glu Ser Thr Ala Leu Phe
    210                 215                 220                 
Pro Ser Val Tyr Leu Asn Ile Lys Leu Lys Ser Thr Pro Lys Ala Ala
225                 230                 235                 240 
Phe Tyr Val Arg Asn Arg Val Gln Glu Ala Ile Arg Leu Ser Lys Ile
                245                 250                 255     
Ala Ser Val Glu Ser Pro Leu Pro Val Phe Val Tyr His Arg Pro Val
            260                 265                 270         
Phe Thr Asp Gly Ser Ser Thr Tyr Leu Ser Gln Gly Asp Leu Val Asn
        275                 280                 285             
Ser Val Gly Glu Ile Val Ala Leu Gly Ala Ser Gly Ile Ile Met Trp
    290                 295                 300                 
Gly Ser Leu Asn Leu Ser Leu Thr Met Gln Ser Cys Met Asn Leu Gly
305                 310                 315                 320 
Asn Tyr Leu Asn Thr Thr Leu Asn Pro Tyr Ile Ile Asn Val Thr Leu
                325                 330                 335     
Ala Ala Lys Met Cys Ser Gln Val Leu Cys His Asp Glu Gly Val Cys
            340                 345                 350         
Thr Arg Lys Gln Trp Asn Ser Ser Asp Tyr Leu His Leu Asn Pro Met
        355                 360                 365             
Asn Phe Ala Ile Gln Thr Gly Lys Gly Gly Lys Tyr Thr Val Pro Gly
    370                 375                 380                 
Lys Val Thr Leu Glu Asp Leu Gln Thr Phe Ser Asp Lys Phe Tyr Cys
385                 390                 395                 400 
Ser Cys Tyr Ala Asn Ile Asn Cys Lys Lys Arg Val Asp Ile Lys Asn
                405                 410                 415     
Val His Ser Val Asn Val Cys Met Ala Glu Asp Ile Cys Ile Glu Gly
            420                 425                 430         
Pro Val Lys Leu Gln Pro Ser Asp His Ser Ser Ser Gln Asn Glu Ala
        435                 440                 445             
Ser Thr Thr Thr Val Ser Ser Ile Ser Pro Ser Thr Thr Ala Thr Thr
    450                 455                 460                 
Val Ser Pro Cys Thr Pro Glu Lys Gln Ser Pro Glu Cys Leu Lys Val
465                 470                 475                 480 
Arg Cys Leu Glu Ala Ile Ala Asn Val Thr Gln Thr Gly Cys Gln Gly
                485                 490                 495     
Val Lys Trp Lys Asn Thr Ser Ser Gln Ser Ser Ile Gln Asn Ile Lys
            500                 505                 510         
Asn Gln Thr Thr Tyr
        515         


<210> 274
<211> 1620
<212> DNA
<213> Ovis aries

<400> 274
ttttccgtgt tggttggctc tggacttcag agcaccccct ctcatttcaa acacttcttt 60
cctctgggcc tggaatgccc cagctgaacg ttgtattaaa atctttaaac tacctccaga 120
tctgagactc ttctctgtaa aaggaagccc ccaaaaaagt gctacgggac aatttattac 180
attattttat gctgatagac ttggctacta tcctcatata gatgaaaaaa caggcaacac 240
tgtatatgga ggaattcccc agttgggaaa cttaaaaaat catttggaaa aagccaaaaa 300
agacattgcc tattacatac caaatgacag cgtgggcttg gcggtcattg actgggaaaa 360
ctggaggcct acctgggcaa gaaactggaa acctaaagat gtttacaggg atgagtctgt 420
tgagttggtt ctgcaaaaaa atccacaact cagtttccca gaggcttcca agattgcaaa 480
agtggatttt gagacagcag gaaagagttt catgcaagag actttaaaac tgggaaaatt 540
acttcggcca aatcacttat ggggttatta tctttttcct gattgttaca atcataatta 600
taaccagcct acttacaatg gaaattgctc tgatttagaa aaaaggagaa atgatgatct 660
cgactggttg tggaaggaaa gcactgccct tttcccttct gtttatttga atatcaagtt 720
aaaatctact ccaaaagctg ccttctatgt tcgtaatcgt gtccaggaag ccattcggtt 780
gtctaaaata gcgagtgttg aaagtccact tcccgttttt gtatatcacc gtccagtttt 840
tactgatggg tcttcaacat acctttctca gggtgacctt gtgaattcgg ttggtgagat 900
cgttgctcta ggtgcctctg ggattataat gtggggcagt ctcaatctaa gcctaactat 960
gcaatcttgc atgaacctag gcaattactt gaacactaca ctgaatcctt acataatcaa 1020
cgtcacccta gcagccaaaa tgtgcagcca agtgctttgc cacgatgaag gagtgtgtac 1080
aaggaaacaa tggaattcaa gcgactatct tcacctgaac ccaatgaatt ttgctattca 1140
aactgggaaa ggtggaaaat acacagtacc tgggaaagtc acacttgaag acctgcaaac 1200
gttttctgat aaattttatt gcagttgtta tgccaacatc aactgtaaga agagagttga 1260
tataaaaaat gttcatagtg ttaatgtatg tatggcagaa gacatttgta tagagggccc 1320
tgtgaagtta caacccagtg atcattcctc tagccagaat gaggcatcta ctaccaccgt 1380
cagcagtatc tcaccctcta ctacagccac cacagtatct ccatgtactc ctgagaaaca 1440
gtcccctgag tgcctcaaag tcaggtgttt ggaagccatc gccaacgtca cccaaacggg 1500
gtgtcaaggt gttaaatgga agaacacttc cagtcagtca agtattcaaa atattaaaaa 1560
tcaaacaacc tattaaaata taaattcagt gcttataaaa aaaaaaaaaa aaaaaaaaaa 1620


<210> 275
<211> 793
<212> PRT
<213> Arthrobacter sp. (strain FB24) 

<220> 
<223> hyaluronan lyase

<400> 275
Met Thr Arg Glu Phe Ser Arg Arg Thr Ala Leu Lys Gly Ala Ala Leu
 1               5                  10                  15      
Ser Gly Leu Leu Leu Ala Met Val His Gly Pro Ala His Ala Ala Ala
            20                  25                  30          
Thr Ala Asn Ala Thr Leu Thr Pro Ala Asp Phe Ala Gly Leu Arg Gln
        35                  40                  45              
Arg Trp Val Asp Gln Ile Thr Gly Arg Lys Val Leu Val Ala Gly Asp
    50                  55                  60                  
Asn Asp Phe Val Thr Ala Leu Ala Ala Leu Asp Lys Lys Ala Arg Thr
65                  70                  75                  80  
Ala Ile Asp Leu Leu Glu Arg Ser Ala Gly Arg Leu Thr Val Phe Ser
                85                  90                  95      
Asp Leu Ser Leu Ala Lys Asp Thr Asp Leu Val Thr Thr His Thr Arg
            100                 105                 110         
Leu Ala Thr Met Ala Thr Ala Trp Ala Thr Pro Gly Ser Glu His Phe
        115                 120                 125             
Ala Asp Ala Gly Leu Leu Ala Ala Ile Arg Ala Gly Leu Ala Asp Ala
    130                 135                 140                 
Asn Ser Leu Cys Tyr Asn Ala Ser Lys Glu Glu Gln Gly Asn Trp Trp
145                 150                 155                 160 
Ser Trp Glu Ile Gly Thr Pro Lys Ala Leu Ala Asp Thr Met Val Leu
                165                 170                 175     
Leu His Ala Glu Leu Thr Ala Ala Glu Arg Ala Ala Tyr Cys Ala Ala
            180                 185                 190         
Ile Asp His Phe Val Pro Asp Pro Trp Gln Gln Phe Pro Pro Lys Arg
        195                 200                 205             
Gly Lys Ile Thr Ser Val Gly Ala Asn Arg Val Asp Leu Cys Gln Ala
    210                 215                 220                 
Val Thr Ile Arg Ser Leu Val Asp Glu Asp Ala Glu Lys Leu Thr His
225                 230                 235                 240 
Ala Val Ala Gly Leu Ser Glu Val Trp Gln Tyr Val Ser Ala Gly Asn
                245                 250                 255     
Gly Phe Phe Thr Asp Gly Ser Phe Ile Gln His Ser Thr Thr Pro Tyr
            260                 265                 270         
Thr Gly Ser Tyr Gly Val Val Leu Leu Thr Gly Leu Ser Lys Leu Phe
        275                 280                 285             
Ala Leu Leu Gly Gly Thr Gly Ala Glu Val Ser Asp Pro Ser Arg Asp
    290                 295                 300                 
Ile Leu Phe Lys Thr Val Glu Gly Ser Phe Ala Pro Phe Met Val Ala
305                 310                 315                 320 
Gly Ala Met Ala Asp Ser Val Arg Gly Arg Ser Ile Ser Arg Glu Ser
                325                 330                 335     
Asn Thr Gly Phe Asp Leu Gly Ala Ser Thr Ile Glu Ser Ile Leu Leu
            340                 345                 350         
Leu Ala Arg Ala Val Asp Pro Val Thr Ala Arg Arg Trp Arg Ser Leu
        355                 360                 365             
Cys Leu Ala Trp Ile Asn Gln Asn Arg Lys Ala Pro Ile Leu Ala Asp
    370                 375                 380                 
Ala Gly Val Gly Arg Thr Ala Leu Val Lys Glu Leu Leu Ala Met Gly
385                 390                 395                 400 
Leu Thr Glu Thr Asp Leu Pro Gly Gly His Tyr Leu Phe Pro Ala Met
                405                 410                 415     
Asp Arg Thr Met His His Ser Gln Gly Trp Thr Leu Ser Thr Ala Met
            420                 425                 430         
Ala Ser Ser Arg Ile Ala Trp Tyr Glu Cys Gly Asn Gly Glu Asn Asn
        435                 440                 445             
Arg Gly Tyr His Thr Gly Ser Gly Met Thr Tyr Val Tyr Asp Gly Asp
    450                 455                 460                 
Leu Gly Gln Tyr Asp Asp Ala Phe Trp Ala Thr Ala Asn His Cys Arg
465                 470                 475                 480 
Leu Pro Gly Ile Thr Val Asp Thr Ser Ser Leu Pro Asp Lys Val Glu
                485                 490                 495     
Gly Glu Trp Gly Ala Ala Thr Pro Ala Asn Glu Trp Thr Gly Ser Thr
            500                 505                 510         
Ala Tyr Gly Asp Val Ala Ala Val Gly Gln His Leu Ile Gly Pro Gly
        515                 520                 525             
Gly Thr Gly Leu Thr Ala Arg Lys Ser Trp Phe Val Ser Lys Asp Val
    530                 535                 540                 
Ile Val Cys Leu Gly Ala Asp Ile Arg Thr Gly Ser Gly Ser Arg Ile
545                 550                 555                 560 
Glu Thr Val Val Asp His Arg Asn Leu His Ala Gly Phe Asn Ala Met
                565                 570                 575     
Gly Thr Ala Ala Gly Thr Val Ala Ala Thr Pro Gly His Pro Glu Val
            580                 585                 590         
Leu Thr Val Asp Arg Trp Val His Leu Glu Gly Phe Gly Gly Tyr Val
        595                 600                 605             
Val Leu Asp Ala Ala Pro Leu Gln Val Leu Arg Glu Gln Arg Glu Gly
    610                 615                 620                 
Ser Trp Ser Glu Val Asn Val Lys Gly Ser Ala Ala Arg Gln Thr Arg
625                 630                 635                 640 
Asn Tyr Ala Thr Leu Tyr Phe Asp His Gly His Glu Pro Glu Ala Ala
                645                 650                 655     
Ser Tyr Ala Tyr Leu Val Ala Pro Gly Ala Ser Ala Ser Met Thr Ser
            660                 665                 670         
Ser Leu Ser Gly Gln Ser Phe His Thr Val Leu Arg Asn Asp Glu Val
        675                 680                 685             
Ala Gln Ala Val Lys Phe Lys Lys Glu Lys Thr Thr Ala Ala Thr Phe
    690                 695                 700                 
Trp Arg Pro Gly Thr Val Gly Asp Leu Ala Leu Ser Gly Pro Ala Cys
705                 710                 715                 720 
Val Val Val Lys Glu Val Gly Asp Arg Leu Ser Ile Ala Val Ser Asp
                725                 730                 735     
Pro Thr Gln Asn Ala Ser Thr Leu Thr Leu Arg Leu Lys Thr Lys Arg
            740                 745                 750         
Phe Phe Arg Ile Ile Glu Gly Gln Gly Ala Ser Leu Ser His Gly Ala
        755                 760                 765             
Asp Gly Phe Thr Val Leu Glu Val Asp Ile Ala Asn His Ala Gly Arg
    770                 775                 780                 
Thr Lys Gln Ile Glu Leu Ser Ala Glu
785                 790             


<210> 276
<211> 557
<212> PRT
<213> Bdellovibrio bacteriovorus

<220> 
<223> hyaluronan lyase

<400> 276
Met Thr Lys Phe Phe Phe Leu Leu Thr Leu Ile Ser Ala Thr Ala Phe
 1               5                  10                  15      
Ala Gln Ser Glu Pro Asp Trp Thr Ala Gly Val Pro Val Pro Pro Gly
            20                  25                  30          
Gly Arg Ser Asn Ile Tyr Ser Trp Asn Asp Phe Asp Phe Gln Ala Thr
        35                  40                  45              
Leu Asn Lys Gly Lys Ile His Ala Gln Val Tyr Pro Val Thr Val Thr
    50                  55                  60                  
Gly Met Leu Pro Pro Tyr Glu Pro Val Arg Arg Leu Ile Glu Glu Lys
65                  70                  75                  80  
Asn Ser Asn Pro Leu Arg Lys Trp Ile Gln Ser Leu Met Lys Gly Leu
                85                  90                  95      
Ser Gly Phe Arg Ser Phe Glu Asp Val Leu Lys Asn Leu Gly Leu His
            100                 105                 110         
Lys Tyr Pro Leu Glu Asn Glu Arg Gly Val Tyr Ala Val Pro Tyr Pro
        115                 120                 125             
Asn Glu Ile Arg Pro Asp Thr Leu Met Gly Phe Gly Leu Ile Glu Arg
    130                 135                 140                 
Asn Gly Ala Glu Gly Phe Thr Phe Ser Cys Ala Ala Cys His Ser Ser
145                 150                 155                 160 
Asn Leu Phe Gly Lys Thr Val Leu Gly Met Thr Asn Arg Phe Pro Arg
                165                 170                 175     
Ala Asn Glu Phe Phe Ile Lys Ala Lys Lys Val Met Pro Leu Met Asp
            180                 185                 190         
Pro His Ile Phe Gln Ala Tyr Thr Arg Ala Thr Asp Ala Glu Thr Ala
        195                 200                 205             
Leu Leu Val Glu Ser Lys Glu Arg Leu Lys Ser Val Ala Leu Lys Gln
    210                 215                 220                 
Pro Ile Ala Leu Gly Leu Asp Thr Ser Leu Ala Gln Val Ser Leu Ser
225                 230                 235                 240 
Leu Asn Arg Arg Ala Lys Asp Gly Tyr Ala Asn Tyr Ser Asp Lys Ala
                245                 250                 255     
Ala Arg Ser Pro Arg Ala Asp Ala Tyr Leu Asp Asn Lys Pro Ala Asp
            260                 265                 270         
Ser Lys Pro Ala Val Trp Trp Asn Val Lys Tyr Lys Asn Arg Trp Leu
        275                 280                 285             
Ser Asp Gly Ser Val Leu Ser Gly Asn Pro Ile Phe Thr Asn Leu Ile
    290                 295                 300                 
Trp Asn Glu Ile Gly Arg Gly Ala Asp Leu His Glu Leu Glu Gln Trp
305                 310                 315                 320 
Leu Ala Asp Asn Asp His Ile Ile Lys Glu Leu Thr Thr Ala Val Phe
                325                 330                 335     
Ala Ser Glu Ala Pro His Ile Thr Asp Phe Tyr Pro Ala Glu Lys Ile
            340                 345                 350         
Asp Leu Gly Arg Ala Lys Ala Gly Glu Gln Ile Phe Lys Asn Thr Cys
        355                 360                 365             
Ala Lys Cys His Gly His Tyr Glu Lys Ala Trp Asn Leu Pro Gln Ala
    370                 375                 380                 
Leu Val Leu Ser Ala Ala Glu Arg Leu Lys Thr Val Glu Val Arg Tyr
385                 390                 395                 400 
Lys Glu Lys Thr Pro Val Val Asn Val Gly Thr Asp Pro Phe Arg Arg
                405                 410                 415     
Gln Gly Met Lys Ser Leu Glu Gln Leu Asn Asp Leu Glu Ile Ser Lys
            420                 425                 430         
Lys Asn Gly Ile Val Ile Lys Ala Gln Glu Gly Tyr Val Pro Pro Pro
        435                 440                 445             
Leu Val Gly Ile Trp Ala Arg Trp Pro Tyr Met His Asn Asn Ser Ile
    450                 455                 460                 
Pro Asn Leu Cys Val Leu Leu Thr Pro Ala Lys Lys Arg Pro Ser Ile
465                 470                 475                 480 
Tyr Tyr Ser Gly Glu Ala Leu Asn Lys Asp Thr Asp Tyr Asp Phe Ser
                485                 490                 495     
Cys Gly Gly Tyr Pro Ile Gly Asp Lys Thr Pro Lys Ala Trp Lys Thr
            500                 505                 510         
Arg Glu His Leu Tyr Asp Thr Arg Asn Pro Gly Met Gly Asn Met Gly
        515                 520                 525             
His Asp Glu Gly Ile Phe Ile Lys Asp Gly Lys Glu Ile Leu Ser Ala
    530                 535                 540                 
Glu Asp Lys Tyr Asn Leu Ile Gln Phe Leu Gln Thr Leu
545                 550                 555         


<210> 277
<211> 813
<212> PRT
<213> Propionibacterium acnes

<220> 
<223> hyaluronan lyase

<400> 277
Met Phe Gly Thr Pro Ser Arg Arg Thr Phe Leu Thr Ala Ser Ala Leu
 1               5                  10                  15      
Ser Ala Met Ala Leu Ala Ala Ser Pro Thr Val Thr Asp Ala Ile Ala
            20                  25                  30          
Ala Pro Gly Pro Asp Ser Trp Ser Ala Leu Cys Glu Arg Trp Ile Asp
        35                  40                  45              
Ile Ile Thr Gly Arg Arg Ala Ala Arg Thr Ser Asp Pro Arg Ala Arg
    50                  55                  60                  
Ala Ile Ile Ala Lys Thr Asp Arg Lys Val Ala Glu Ile Leu Thr Asp
65                  70                  75                  80  
Leu Val Ser Gly Ser Ser Arg Gln Thr Val Leu Ile Ser Ala Asp Leu
                85                  90                  95      
Arg Lys Glu Gln Ser Pro Phe Ile Thr Lys Thr Ala Arg Ala Ile Glu
            100                 105                 110         
Ser Met Ala Cys Ala Trp Ala Thr Pro Gly Ser Ser Tyr His Lys Asp
        115                 120                 125             
Pro Glu Ile Leu Ser Ala Cys Ile Glu Gly Leu Arg Asp Phe Cys Arg
    130                 135                 140                 
Leu Arg Tyr Asn Pro Ser Gln Asp Glu Tyr Gly Asn Trp Trp Asp Trp
145                 150                 155                 160 
Glu Asp Gly Ala Ser Arg Ala Val Ala Asp Val Met Cys Ile Leu His
                165                 170                 175     
Asp Val Leu Pro Pro Glu Val Met Ser Ala Ala Ala Ala Gly Ile Asp
            180                 185                 190         
His Phe Ile Pro Asp Pro Trp Phe Gln Gln Pro Ala Ser Val Lys Pro
        195                 200                 205             
Thr Ala Asn Pro Val Gln Pro Val Val Ser Thr Gly Ala Asn Arg Met
    210                 215                 220                 
Asp Leu Thr Arg Ala Val Met Cys Arg Ser Ile Ala Thr Gly Asp Glu
225                 230                 235                 240 
Lys Arg Leu Arg His Ala Val Asp Gly Leu Pro Asp Ala Trp Arg Val
                245                 250                 255     
Thr Thr Glu Gly Asp Gly Phe Arg Ala Asp Gly Gly Phe Ile Gln His
            260                 265                 270         
Ser His Ile Pro Tyr Thr Gly Gly Tyr Gly Asp Val Leu Phe Ser Gly
        275                 280                 285             
Leu Ala Met Leu Phe Pro Leu Val Ser Gly Met Arg Phe Asp Ile Val
    290                 295                 300                 
Glu Ser Ala Arg Lys Ala Phe His Asp Gln Val Glu Arg Gly Phe Ile
305                 310                 315                 320 
Pro Val Met Tyr Asn Gly Gln Ile Leu Asp Asp Val Arg Gly Arg Ser
                325                 330                 335     
Ile Ser Arg Ile Asn Glu Ser Ala Ala Met His Gly Ile Ser Ile Ala
            340                 345                 350         
Arg Ala Met Leu Met Met Ala Asp Ala Leu Pro Thr His Arg Ala Glu
        355                 360                 365             
Gln Trp Arg Gly Ile Val His Gly Trp Met Ala Arg Asn Thr Phe Asp
    370                 375                 380                 
His Leu Ser Glu Pro Ser Thr Leu Val Asp Ile Ser Leu Phe Asp Ala
385                 390                 395                 400 
Ala Ala Lys Ala Arg Pro Val Pro Glu Ser Ser Thr Pro Ser Tyr Phe
                405                 410                 415     
Ala Ser Met Asp Arg Leu Val His Arg Thr Ala Asp Trp Leu Ile Thr
            420                 425                 430         
Val Ser Asn Cys Ser Asp Arg Ile Ala Trp Tyr Glu Tyr Gly Asn Gly
        435                 440                 445             
Glu Asn Glu Trp Ala Ser Arg Thr Ser Gln Gly Met Arg Tyr Leu Leu
    450                 455                 460                 
Leu Pro Gly Asp Met Gly Gln Tyr Glu Asp Gly Tyr Trp Ala Thr Val
465                 470                 475                 480 
Asp Tyr Ser Ala Pro Thr Gly Thr Thr Val Asp Ser Thr Pro Leu Lys
                485                 490                 495     
Arg Ala Val Gly Ala Ser Trp Ala Ala Lys Thr Pro Thr Asn Glu Trp
            500                 505                 510         
Ser Gly Gly Leu Ala Ser Gly Ser Trp Ser Ala Ala Ala Ser His Ile
        515                 520                 525             
Thr Ser Gln Asp Ser Ala Leu Lys Ala Arg Arg Leu Trp Val Gly Leu
    530                 535                 540                 
Lys Asp Ala Met Val Glu Leu Thr Thr Asp Val Thr Thr Asp Ala Ser
545                 550                 555                 560 
Arg Ala Ile Thr Val Val Glu His Arg Lys Val Ala Ser Ser Ser Thr
                565                 570                 575     
Lys Leu Leu Val Asp Gly Asn Arg Val Ser Ser Ala Thr Ser Phe Gln
            580                 585                 590         
Asn Pro Arg Trp Ala His Leu Asp Gly Val Gly Gly Tyr Val Phe Ala
        595                 600                 605             
Thr Asp Thr Asp Leu Ser Ala Asp Val Ala Thr Arg Lys Gly Thr Trp
    610                 615                 620                 
Ile Asp Val Asn Pro Ser Arg Lys Val Lys Gly Ala Asp Glu Val Ile
625                 630                 635                 640 
Glu Arg Ala Tyr Ala Ser Leu His Val Thr His His Asp Arg Pro Val
                645                 650                 655     
Ala Trp Ala Leu Leu Pro Thr Ala Ser Arg Ser His Thr Met Ala Leu
            660                 665                 670         
Ala Thr Arg Pro Gly Val Glu Pro Phe Thr Val Leu Arg Asn Asp Ala
        675                 680                 685             
Thr Val Gln Ala Val Arg Ser Ala Gly Ala Leu Leu Thr Lys Asp Pro
    690                 695                 700                 
Thr Val Val Thr Thr Leu Ala Phe Trp Lys Pro Ala Thr Cys Gly Gly
705                 710                 715                 720 
Val Ala Val Asn Arg Pro Ala Leu Val Gln Thr Arg Glu Ser Ala Asn
                725                 730                 735     
Gln Met Glu Val Val Ile Val Glu Pro Thr Gln Lys Arg Gly Ser Leu
            740                 745                 750         
Thr Val Thr Ile Glu Gly Ser Trp Lys Val Lys Thr Ala Asp Ser His
        755                 760                 765             
Val Asp Val Ser Cys Glu Asn Ala Ala Gly Thr Leu His Val Asp Thr
    770                 775                 780                 
Ala Gly Leu Gly Gly Gln Ser Val Arg Val Thr Leu Ala Arg Gln Val
785                 790                 795                 800 
Thr Gln Thr Pro Ser Gly Gly Gly Arg His Asp Arg Ala
                805                 810             


<210> 278
<211> 1072
<212> PRT
<213> Streptococcus agalactiae

<220> 
<223> hyaluronan lyase

<400> 278
Met Glu Ile Lys Lys Lys Tyr Arg Ile Met Leu Tyr Ser Ala Leu Ile
 1               5                  10                  15      
Leu Gly Thr Ile Leu Val Asn Asn Ser Tyr Gln Ala Lys Ala Glu Glu
            20                  25                  30          
Leu Thr Lys Thr Thr Ser Thr Ser Gln Ile Arg Asp Thr Gln Thr Asn
        35                  40                  45              
Asn Ile Glu Val Leu Gln Thr Glu Ser Thr Thr Val Lys Glu Thr Ser
    50                  55                  60                  
Thr Thr Thr Thr Gln Gln Asp Leu Ser Asn Pro Thr Ala Ser Thr Ala
65                  70                  75                  80  
Thr Ala Thr Ala Thr His Ser Thr Met Lys Gln Val Val Asp Asn Gln
                85                  90                  95      
Thr Gln Asn Lys Glu Leu Val Lys Asn Gly Asp Phe Asn Gln Thr Asn
            100                 105                 110         
Pro Val Ser Gly Ser Trp Ser His Thr Ser Ala Arg Glu Trp Ser Ala
        115                 120                 125             
Trp Ile Asp Lys Glu Asn Thr Ala Asp Lys Ser Pro Ile Ile Gln Arg
    130                 135                 140                 
Thr Glu Gln Gly Gln Val Ser Leu Ser Ser Asp Lys Gly Phe Arg Gly
145                 150                 155                 160 
Ala Val Thr Gln Lys Val Asn Ile Asp Pro Thr Lys Lys Tyr Glu Val
                165                 170                 175     
Lys Phe Asp Ile Glu Thr Ser Asn Lys Ala Gly Gln Ala Phe Leu Arg
            180                 185                 190         
Ile Met Glu Lys Lys Asp Asn Asn Thr Arg Leu Trp Leu Ser Glu Met
        195                 200                 205             
Thr Ser Gly Thr Thr Asn Lys His Thr Leu Thr Lys Ile Tyr Asn Pro
    210                 215                 220                 
Lys Leu Asn Val Ser Glu Val Thr Leu Glu Leu Tyr Tyr Glu Lys Gly
225                 230                 235                 240 
Thr Gly Ser Ala Thr Phe Asp Asn Ile Ser Met Lys Ala Lys Gly Pro
                245                 250                 255     
Lys Asp Ser Glu His Pro Gln Pro Val Thr Thr Gln Ile Glu Glu Ser
            260                 265                 270         
Val Asn Thr Ala Leu Asn Lys Asn Tyr Val Phe Asn Lys Ala Asp Tyr
        275                 280                 285             
Gln Tyr Thr Leu Thr Asn Pro Ser Leu Gly Lys Ile Val Gly Gly Ile
    290                 295                 300                 
Leu Tyr Pro Asn Ala Thr Gly Ser Thr Thr Val Lys Ile Ser Asp Lys
305                 310                 315                 320 
Ser Gly Lys Ile Ile Lys Glu Val Pro Leu Ser Val Thr Ala Ser Thr
                325                 330                 335     
Glu Asp Lys Phe Thr Lys Leu Leu Asp Lys Trp Asn Asp Val Thr Ile
            340                 345                 350         
Gly Asn His Val Tyr Asp Thr Asn Asp Ser Asn Met Gln Lys Ile Asn
        355                 360                 365             
Gln Lys Leu Asp Glu Thr Asn Ala Lys Asn Ile Lys Thr Ile Lys Leu
    370                 375                 380                 
Asp Ser Asn His Thr Phe Leu Trp Lys Asp Leu Asp Asn Leu Asn Asn
385                 390                 395                 400 
Ser Ala Gln Leu Thr Ala Thr Tyr Arg Arg Leu Glu Asp Leu Ala Lys
                405                 410                 415     
Gln Ile Thr Asn Pro His Ser Thr Ile Tyr Lys Asn Glu Lys Ala Ile
            420                 425                 430         
Arg Thr Val Lys Glu Ser Leu Ala Trp Leu His Gln Asn Phe Tyr Asn
        435                 440                 445             
Val Asn Lys Asp Ile Glu Gly Ser Ala Asn Trp Trp Asp Phe Glu Ile
    450                 455                 460                 
Gly Val Pro Arg Ser Ile Thr Ala Thr Leu Ala Leu Met Asn Asn Tyr
465                 470                 475                 480 
Phe Thr Asp Ala Glu Ile Lys Thr Tyr Thr Asp Pro Ile Glu His Phe
                485                 490                 495     
Val Pro Asp Ala Gly Tyr Phe Arg Lys Thr Leu Asp Asn Pro Phe Lys
            500                 505                 510         
Ala Leu Gly Gly Asn Leu Val Asp Met Gly Arg Val Lys Ile Ile Glu
        515                 520                 525             
Gly Leu Leu Arg Lys Asp Asn Thr Ile Ile Glu Lys Thr Ser His Ser
    530                 535                 540                 
Leu Lys Asn Leu Phe Thr Thr Ala Thr Lys Ala Glu Gly Phe Tyr Ala
545                 550                 555                 560 
Asp Gly Ser Tyr Ile Asp His Thr Asn Val Ala Tyr Thr Gly Ala Tyr
                565                 570                 575     
Gly Asn Val Leu Ile Asp Gly Leu Thr Gln Leu Leu Pro Ile Ile Gln
            580                 585                 590         
Glu Thr Asp Tyr Lys Ile Ser Asn Gln Glu Leu Asp Met Val Tyr Lys
        595                 600                 605             
Trp Ile Asn Gln Ser Phe Leu Pro Leu Ile Val Lys Gly Glu Leu Met
    610                 615                 620                 
Asp Met Ser Arg Gly Arg Ser Ile Ser Arg Glu Ala Ala Ser Ser His
625                 630                 635                 640 
Ala Ala Ala Val Glu Val Leu Arg Gly Phe Leu Arg Leu Ala Asn Met
                645                 650                 655     
Ser Asn Glu Glu Arg Asn Leu Asp Leu Lys Ser Thr Ile Lys Thr Ile
            660                 665                 670         
Ile Thr Ser Asn Lys Phe Tyr Asn Val Phe Asn Asn Leu Lys Ser Tyr
        675                 680                 685             
Ser Asp Ile Ala Asn Met Asn Lys Met Leu Asn Asp Ser Thr Val Ala
    690                 695                 700                 
Thr Lys Pro Leu Lys Ser Asn Leu Ser Thr Phe Asn Ser Met Asp Arg
705                 710                 715                 720 
Leu Ala Tyr Tyr Asn Ala Glu Lys Asp Phe Gly Phe Ala Leu Ser Leu
                725                 730                 735     
His Ser Lys Arg Thr Leu Asn Tyr Glu Gly Met Asn Asp Glu Asn Thr
            740                 745                 750         
Arg Gly Trp Tyr Thr Gly Asp Gly Met Phe Tyr Leu Tyr Asn Ser Asp
        755                 760                 765             
Gln Ser His Tyr Ser Asn His Phe Trp Pro Thr Val Asn Pro Tyr Lys
    770                 775                 780                 
Met Ala Gly Thr Thr Glu Lys Asp Ala Lys Arg Glu Asp Thr Thr Lys
785                 790                 795                 800 
Glu Phe Met Ser Lys His Ser Lys Asp Ala Lys Glu Lys Thr Gly Gln
                805                 810                 815     
Val Thr Gly Thr Ser Asp Phe Val Gly Ser Val Lys Leu Asn Asp His
            820                 825                 830         
Phe Ala Leu Ala Ala Met Asp Phe Thr Asn Trp Asp Arg Thr Leu Thr
        835                 840                 845             
Ala Gln Lys Gly Trp Val Ile Leu Asn Asp Lys Ile Val Phe Leu Gly
    850                 855                 860                 
Ser Asn Ile Lys Asn Thr Asn Gly Ile Gly Asn Val Ser Thr Thr Ile
865                 870                 875                 880 
Asp Gln Arg Lys Asp Asp Ser Lys Thr Pro Tyr Thr Thr Tyr Val Asn
                885                 890                 895     
Gly Lys Thr Ile Asp Leu Lys Gln Ala Ser Ser Gln Gln Phe Thr Asp
            900                 905                 910         
Thr Lys Ser Val Phe Leu Glu Ser Lys Glu Pro Gly Arg Asn Ile Gly
        915                 920                 925             
Tyr Ile Phe Phe Lys Asn Ser Thr Ile Asp Ile Glu Arg Lys Glu Gln
    930                 935                 940                 
Thr Gly Thr Trp Asn Ser Ile Asn Arg Thr Ser Lys Asn Thr Ser Ile
945                 950                 955                 960 
Val Ser Asn Pro Phe Ile Thr Ile Ser Gln Lys His Asp Asn Lys Gly
                965                 970                 975     
Asp Ser Tyr Gly Tyr Met Met Val Pro Asn Ile Asp Arg Thr Ser Phe
            980                 985                 990         
Asp Lys Leu Ala Asn Ser Lys Glu Val Glu Leu Leu Glu Asn Ser Ser
        995                 1000                1005            
Lys Gln Gln Val Ile Tyr Asp Lys Asn Ser Gln Thr Trp Ala Val Ile
    1010                1015                1020                
Lys His Asp Asn Gln Glu Ser Leu Ile Asn Asn Gln Phe Lys Met Asn
1025                1030                1035               1040 
Lys Ala Gly Leu Tyr Leu Val Gln Lys Val Gly Asn Asp Tyr Gln Asn
                1045                1050                1055    
Val Tyr Tyr Gln Pro Gln Thr Met Thr Lys Thr Asp Gln Leu Ala Ile
            1060                1065                1070        


<210> 279
<211> 1072
<212> PRT
<213> Streptococcus agalactiae 18RS21

<220> 
<223> hyaluronan lyase

<400> 279
Met Glu Ile Lys Lys Lys His Arg Ile Met Leu Tyr Ser Ala Leu Ile
 1               5                  10                  15      
Leu Gly Thr Ile Leu Val Asn Asn Ser Tyr Gln Ala Lys Ala Glu Glu
            20                  25                  30          
Leu Thr Lys Thr Thr Ser Thr Ser Gln Ile Arg Asp Thr Gln Thr Asn
        35                  40                  45              
Asn Ile Glu Val Leu Gln Thr Glu Ser Thr Thr Val Lys Glu Thr Ser
    50                  55                  60                  
Thr Thr Thr Thr Gln Gln Asp Leu Ser Asn Pro Thr Ala Ser Thr Ala
65                  70                  75                  80  
Thr Ala Thr Ala Thr His Ser Thr Met Lys Gln Val Val Asp Asn Gln
                85                  90                  95      
Thr Gln Asn Lys Glu Leu Val Lys Asn Gly Asp Phe Asn Gln Thr Asn
            100                 105                 110         
Pro Val Ser Gly Ser Trp Ser His Thr Ser Ala Arg Glu Trp Ser Ala
        115                 120                 125             
Trp Ile Asp Lys Glu Asn Thr Ala Asp Lys Ser Pro Ile Ile Gln Arg
    130                 135                 140                 
Thr Glu Gln Gly Gln Val Ser Leu Ser Ser Asp Lys Gly Phe Arg Gly
145                 150                 155                 160 
Ala Val Thr Gln Lys Val Asn Ile Asp Pro Thr Lys Lys Tyr Glu Val
                165                 170                 175     
Lys Phe Asp Ile Glu Thr Ser Asn Lys Ala Gly Gln Ala Phe Leu Arg
            180                 185                 190         
Ile Met Glu Lys Lys Asp Asn Asn Thr Arg Leu Trp Leu Ser Glu Met
        195                 200                 205             
Thr Ser Gly Thr Thr Asn Lys His Thr Leu Thr Lys Ile Tyr Asn Pro
    210                 215                 220                 
Lys Leu Asn Val Ser Glu Val Thr Leu Glu Leu Tyr Tyr Glu Lys Gly
225                 230                 235                 240 
Thr Gly Ser Ala Thr Phe Asp Asn Ile Ser Met Lys Ala Lys Gly Pro
                245                 250                 255     
Lys Asp Ser Glu His Pro Gln Pro Val Thr Thr Gln Ile Glu Glu Ser
            260                 265                 270         
Val Asn Thr Ala Leu Asn Lys Asn Tyr Val Phe Asn Lys Ala Asp Tyr
        275                 280                 285             
Gln Tyr Thr Leu Thr Asn Pro Ser Leu Gly Lys Ile Val Gly Gly Ile
    290                 295                 300                 
Leu Tyr Pro Asn Ala Thr Gly Ser Thr Thr Val Lys Ile Ser Asp Lys

305                 310                 315                 320 
Ser Gly Lys Ile Ile Lys Glu Val Pro Leu Ser Val Thr Ala Ser Thr
                325                 330                 335     
Glu Asp Lys Phe Thr Lys Leu Leu Asp Lys Trp Asn Asp Val Thr Ile
            340                 345                 350         
Gly Asn His Val Tyr Asp Thr Asn Asp Ser Asn Met Gln Lys Ile Asn
        355                 360                 365             
Gln Lys Leu Asp Glu Thr Asn Ala Lys Asn Ile Lys Thr Ile Lys Leu
    370                 375                 380                 
Asp Ser Asn His Thr Phe Leu Trp Lys Asp Leu Asp Asn Leu Asn Asn
385                 390                 395                 400 
Ser Ala Gln Leu Thr Ala Thr Tyr Arg Arg Leu Glu Asp Leu Ala Lys
                405                 410                 415     
Gln Ile Thr Asn Pro His Ser Thr Ile Tyr Lys Asn Glu Lys Ala Ile
            420                 425                 430         
Arg Thr Val Lys Glu Ser Leu Ala Trp Leu His Gln Asn Phe Tyr Asn
        435                 440                 445             
Val Asn Lys Asp Ile Glu Gly Ser Ala Asn Trp Trp Asp Phe Glu Ile
    450                 455                 460                 
Gly Val Pro Arg Ser Ile Thr Ala Thr Leu Ala Leu Met Asn Asn Tyr
465                 470                 475                 480 
Phe Thr Asp Ala Glu Ile Lys Thr Tyr Thr Asp Pro Ile Glu His Phe
                485                 490                 495     
Val Pro Asp Ala Gly Tyr Phe Arg Lys Thr Leu Asp Asn Pro Phe Lys
            500                 505                 510         
Ala Leu Gly Gly Asn Leu Val Asp Met Gly Arg Val Lys Ile Ile Glu
        515                 520                 525             
Gly Leu Leu Arg Lys Asp Asn Thr Ile Ile Glu Lys Thr Ser His Ser
    530                 535                 540                 
Leu Lys Asn Leu Phe Thr Thr Ala Thr Lys Ala Glu Gly Phe Tyr Ala
545                 550                 555                 560 
Asp Gly Ser Tyr Ile Asp His Thr Asn Val Ala Tyr Thr Gly Ala Tyr
                565                 570                 575     
Gly Asn Val Leu Ile Asp Gly Leu Thr Gln Leu Leu Pro Ile Ile Gln
            580                 585                 590         
Glu Thr Asp Tyr Lys Ile Ser Asn Gln Glu Leu Asp Met Val Tyr Lys
        595                 600                 605             
Trp Ile Asn Gln Ser Phe Leu Pro Leu Ile Val Lys Gly Glu Leu Met
    610                 615                 620                 
Asp Met Ser Arg Gly Arg Ser Ile Ser Arg Glu Ala Ala Ser Ser His
625                 630                 635                 640 
Ala Ala Ala Val Glu Val Leu Arg Gly Phe Leu Arg Leu Ala Asn Met
                645                 650                 655     
Ser Asn Glu Glu Arg Asn Leu Asp Leu Ile Ser Thr Ile Lys Thr Ile
            660                 665                 670         
Ile Thr Ser Asn Lys Phe Tyr Asn Val Phe Asn Asn Leu Lys Ser Tyr
        675                 680                 685             
Ser Asp Ile Ala Asn Met Asn Lys Met Leu Asn Asp Ser Thr Val Ala
    690                 695                 700                 
Thr Lys Pro Leu Lys Ser Asn Leu Ser Thr Phe Asn Ser Met Asp Arg
705                 710                 715                 720 
Leu Ala Tyr Tyr Asn Ala Glu Lys Asp Phe Gly Phe Ala Leu Ser Leu
                725                 730                 735     
His Ser Lys Arg Thr Leu Asn Tyr Glu Gly Met Asn Asp Glu Asn Thr
            740                 745                 750         
Arg Gly Trp Tyr Thr Gly Asp Gly Met Phe Tyr Leu Tyr Asn Ser Asp
        755                 760                 765             
Gln Ser His Tyr Ser Asn His Phe Trp Pro Thr Val Asn Pro Tyr Lys
    770                 775                 780                 
Met Ala Gly Thr Thr Glu Lys Asp Ala Lys Arg Glu Asp Thr Thr Lys
785                 790                 795                 800 
Glu Phe Met Ser Lys His Ser Lys Asp Ala Lys Glu Lys Thr Gly Gln
                805                 810                 815     
Val Thr Gly Thr Ser Asp Phe Val Gly Ser Val Lys Leu Asn Asp His
            820                 825                 830         
Phe Ala Leu Ala Ala Met Asp Phe Thr Asn Trp Asp Arg Thr Leu Thr
        835                 840                 845             
Ala Gln Lys Gly Trp Val Ile Leu Asn Asp Lys Ile Val Phe Leu Gly
    850                 855                 860                 
Ser Asn Ile Lys Asn Thr Asn Gly Ile Gly Asn Val Ser Thr Thr Ile
865                 870                 875                 880 
Asp Gln Arg Lys Asp Asp Ser Lys Thr Pro Tyr Thr Thr Tyr Val Asn
                885                 890                 895     
Gly Lys Thr Ile Asp Leu Lys Gln Ala Ser Ser Gln Gln Phe Thr Asp
            900                 905                 910         
Thr Lys Ser Val Phe Leu Glu Ser Lys Glu Pro Gly Arg Asn Ile Gly
        915                 920                 925             
Tyr Ile Phe Phe Lys Asn Ser Thr Ile Asp Ile Glu Arg Lys Glu Gln
    930                 935                 940                 
Thr Gly Thr Trp Asn Ser Ile Asn Arg Thr Ser Lys Asn Thr Ser Ile
945                 950                 955                 960 
Val Ser Asn Pro Phe Ile Thr Ile Ser Gln Lys His Asp Asn Lys Gly
                965                 970                 975     
Asp Ser Tyr Gly Tyr Met Met Val Pro Asn Ile Asp Arg Thr Ser Phe
            980                 985                 990         
Asp Lys Leu Ala Asn Ser Lys Glu Val Glu Leu Leu Glu Asn Ser Ser
        995                 1000                1005            
Lys Gln Gln Val Ile Tyr Asp Lys Asn Ser Gln Thr Trp Ala Val Ile
    1010                1015                1020                
Lys His Asp Asn Gln Glu Ser Leu Ile Asn Asn Gln Phe Lys Met Asn
1025                1030                1035               1040 
Lys Ala Gly Leu Tyr Leu Val Gln Lys Val Gly Asn Asp Tyr Gln Asn
                1045                1050                1055    
Val Tyr Tyr Gln Pro Gln Thr Met Thr Lys Thr Asp Gln Leu Ala Ile
            1060                1065                1070        


<210> 280
<211> 1081
<212> PRT
<213> Streptococcus agalactiae serotype Ia

<220> 
<223> hyaluronan lyase

<400> 280
Met Glu Ile Lys Lys Lys His Arg Ile Met Leu Tyr Ser Ala Leu Ile
 1               5                  10                  15      
Leu Gly Thr Ile Leu Val Asn Asn Ser Tyr Gln Ala Lys Ala Glu Glu
            20                  25                  30          
Phe Thr Lys Thr Thr Ser Thr Ser Gln Ile Arg Asp Thr Gln Thr Asn
        35                  40                  45              
Asn Val Glu Val Pro Gln Thr Glu Ser Thr Thr Val Lys Gly Thr Ser
    50                  55                  60                  
Thr Thr Thr Thr Gln Gln Asp Leu Ser Asn Ser Thr Ala Ser Thr Ala
65                  70                  75                  80  
Thr Ala Thr Ala Thr His Ser Thr Met Lys Gln Val Val Asp Asn Gln
                85                  90                  95      
Thr Gln Asn Lys Glu Leu Val Lys Asn Gly Asp Phe Lys Glu Lys Ile
            100                 105                 110         
Ile Asp Lys Lys Ile Asp Lys Lys Ser Gln Trp Thr Asn Leu Tyr Gly
        115                 120                 125             
Ala Lys Asp Trp Asn Thr Tyr Ile Asp Gln Thr Lys Ser Val Asn Lys
    130                 135                 140                 
Ser Pro Ile Ile Gln Arg Thr Glu Gln Gly Gln Val Ser Leu Ser Ser
145                 150                 155                 160 
Asp Lys Gly Phe Arg Gly Ala Val Thr Gln Lys Val Asn Ile Asp Pro
                165                 170                 175     
Thr Lys Lys Tyr Glu Val Lys Phe Asp Ile Glu Thr Ser Asn Lys Val
            180                 185                 190         
Gly Gln Ala Phe Leu Arg Ile Met Lys Lys Lys Asp Lys Asn Thr Arg
        195                 200                 205             
Leu Trp Leu Ser Glu Met Thr Ser Gly Thr Thr Asn Lys His Thr Leu
    210                 215                 220                 
Thr Lys Ile Tyr Asn Pro Lys Leu Asn Val Ser Glu Val Thr Leu Glu
225                 230                 235                 240 
Leu Tyr Tyr Glu Lys Gly Thr Gly Ser Val Thr Phe Asp Asn Ile Ser
                245                 250                 255     
Met Lys Ala Lys Gly Pro Lys Asp Ser Glu His Pro Gln Pro Val Thr
            260                 265                 270         
Thr Gln Ile Glu Glu Ser Val Asn Thr Ala Leu Asn Lys Asn Tyr Val
        275                 280                 285             
Phe Asn Lys Ala Asp Tyr Gln Tyr Thr Leu Thr Asn Pro Ser Leu Gly
    290                 295                 300                 
Lys Ile Val Gly Gly Ile Leu Tyr Pro Ser Ala Thr Gly Ser Thr Thr
305                 310                 315                 320 
Val Lys Ile Ser Asp Lys Ser Gly Lys Ile Ile Lys Glu Val Pro Leu
                325                 330                 335     
Ser Val Thr Ala Ser Thr Glu Asp Asn Phe Thr Lys Leu Leu Asp Lys
            340                 345                 350         
Trp Asn Asp Val Thr Ile Gly Asn His Val Tyr Asp Thr Asn Asp Ser
        355                 360                 365             
Asn Met Gln Lys Leu Asn Gln Lys Leu Asp Glu Thr Asn Ala Lys Asn
    370                 375                 380                 
Ile Lys Asp Ile Lys Leu Asp Ser Asn Arg Thr Phe Leu Trp Glu Asp
385                 390                 395                 400 
Leu Lys Gly Leu Asn Asn Ser Ala Gln Leu Thr Ala Thr Tyr Arg Arg
                405                 410                 415     
Leu Glu Asp Leu Ala Lys Gln Ile Thr Asn Pro His Ser Thr Ile Tyr
            420                 425                 430         
Lys Asn Glu Lys Ala Ile Arg Thr Val Lys Glu Ser Leu Ala Trp Leu
        435                 440                 445             
His Gln Asn Phe Tyr Asn Val Asn Lys Asp Ile Glu Gly Ser Ala Asn
    450                 455                 460                 
Trp Trp Asp Phe Glu Ile Gly Val Pro Arg Ser Ile Thr Ala Thr Leu
465                 470                 475                 480 
Ala Leu Met Asn Asn Tyr Phe Thr Asp Ala Glu Ile Lys Thr Tyr Thr
                485                 490                 495     
Asp Pro Ile Glu His Phe Val Pro Asp Ala Gly Tyr Phe Arg Lys Thr
            500                 505                 510         
Leu Val Asn Pro Phe Lys Ala Leu Gly Gly Asn Leu Val Asp Met Gly
        515                 520                 525             
Arg Val Lys Ile Ile Glu Gly Leu Leu Arg Lys Asp Asn Thr Ile Ile
    530                 535                 540                 
Lys Lys Thr Ser His Ser Leu Lys Asn Leu Phe Thr Thr Ala Thr Lys
545                 550                 555                 560 
Ala Glu Gly Phe Tyr Ala Asp Gly Ser Tyr Ile Asp His Thr Asn Val
                565                 570                 575     
Ala Tyr Thr Gly Ala Tyr Gly Asn Val Leu Ile Asp Gly Leu Thr Gln
            580                 585                 590         
Leu Leu Pro Ile Ile Gln Glu Thr Asp Tyr Lys Ile Ser Asn Gln Glu
        595                 600                 605             
Leu Asp Met Val Tyr Lys Trp Ile Asn Gln Ser Phe Leu Pro Leu Ile
    610                 615                 620                 
Val Lys Gly Glu Leu Met Asp Met Ser Arg Gly Arg Ser Ile Ser Arg
625                 630                 635                 640 
Glu Ala Ala Ser Ser His Ala Ala Ala Val Glu Val Leu Arg Gly Phe
                645                 650                 655     
Leu Arg Leu Ala Asn Met Ser Asn Glu Glu Arg Asn Leu Asp Leu Lys
            660                 665                 670         
Ser Thr Ile Lys Thr Ile Ile Thr Ser Asn Lys Phe Tyr Asn Val Phe
        675                 680                 685             
Asn Asn Leu Lys Ser Tyr Ser Asp Ile Ala Asn Met Asn Lys Leu Leu
    690                 695                 700                 
Asn Asp Ser Thr Val Ala Thr Lys Pro Leu Lys Ser Asn Leu Ser Thr
705                 710                 715                 720 
Phe Asn Ser Met Asp Arg Leu Ala Tyr Tyr Asn Ala Glu Lys Asp Phe
                725                 730                 735     
Gly Phe Ala Leu Ser Leu His Ser Lys Arg Thr Leu Asn Tyr Glu Gly
            740                 745                 750         
Met Asn Asp Glu Asn Thr Arg Gly Trp Tyr Thr Gly Asp Gly Met Phe
        755                 760                 765             
Tyr Leu Tyr Asn Ser Asp Gln Ser His Tyr Ser Asn His Phe Trp Pro
    770                 775                 780                 
Thr Val Asn Pro Tyr Lys Met Ala Gly Thr Thr Glu Lys Asp Thr Gly
785                 790                 795                 800 
Arg Glu Asp Thr Ile Lys Lys Leu Met Asn Arg Tyr Asp Lys Thr Asn
                805                 810                 815     
Lys Asn Ser Lys Val Met Thr Gly Gln Val Thr Gly Thr Ser Asp Phe
            820                 825                 830         
Val Gly Ser Val Lys Leu Asn Asp His Phe Ala Leu Ala Ala Met Asp
        835                 840                 845             
Phe Thr Asn Trp Asp Arg Thr Leu Thr Ala Gln Lys Gly Trp Val Ile
    850                 855                 860                 
Leu Asn Asp Lys Ile Val Phe Leu Gly Ser Asn Ile Lys Asn Thr Asn
865                 870                 875                 880 
Gly Val Gly Asn Val Ser Thr Thr Ile Asp Gln Arg Lys Asp Asp Ser
                885                 890                 895     
Lys Thr Pro Tyr Thr Thr Tyr Val Asn Gly Lys Thr Val Asp Leu Lys
            900                 905                 910         
Gln Ala Ser Ser Gln Gln Phe Thr Asp Thr Lys Ser Val Phe Leu Glu
        915                 920                 925             
Ser Lys Glu Pro Gly Arg Asn Ile Gly Tyr Ile Phe Phe Lys Asn Ser
    930                 935                 940                 
Thr Ile Asp Ile Glu Arg Lys Glu Gln Thr Gly Thr Trp Asn Ser Ile
945                 950                 955                 960 
Asn Arg Thr Ser Lys Asn Thr Ser Ile Val Ser Asn Pro Phe Ile Thr
                965                 970                 975     
Ile Ser Gln Lys His Asp Asn Lys Gly Asp Ser Tyr Gly Tyr Met Met
            980                 985                 990         
Val Pro Asn Ile Asp Arg Thr Ser Phe Asp Lys Leu Ala Asn Ser Lys
        995                 1000                1005            
Glu Val Glu Leu Leu Glu Asn Ser Ser Lys Gln Gln Val Ile Tyr Asp
    1010                1015                1020                
Lys Asn Ser Gln Thr Trp Ala Val Ile Lys His Asp Asn Gln Glu Ser
1025                1030                1035               1040 
Leu Ile Asn Asn Gln Phe Lys Met Asn Lys Ala Gly Leu Tyr Leu Val
                1045                1050                1055    
Gln Lys Val Gly Asn Asp Tyr Gln Asn Val Tyr Tyr Gln Pro Gln Thr
            1060                1065                1070        
Met Thr Lys Thr Asp Gln Leu Ala Ile
        1075                1080    


<210> 281
<211> 984
<212> PRT
<213> Streptococcus agalactiae serotype III

<220> 
<223> hyaluronan lyase

<400> 281
Met Lys Gln Val Val Asp Asn Gln Thr Gln Asn Lys Glu Leu Val Lys
 1               5                  10                  15      
Asn Gly Asp Phe Asn Gln Thr Asn Pro Val Ser Gly Ser Trp Ser His
            20                  25                  30          
Thr Ser Ala Arg Glu Trp Ser Ala Trp Ile Asp Lys Glu Asn Thr Ala
        35                  40                  45              
Asp Lys Ser Pro Ile Ile Gln Arg Thr Glu Gln Gly Gln Val Ser Leu
    50                  55                  60                  
Ser Ser Asp Lys Gly Phe Arg Gly Ala Val Thr Gln Lys Val Asn Ile
65                  70                  75                  80  
Asp Pro Thr Lys Lys Tyr Glu Val Lys Phe Asp Ile Glu Thr Ser Asn
                85                  90                  95      
Lys Ala Gly Gln Ala Phe Leu Arg Ile Met Glu Lys Lys Asp Asn Asn
            100                 105                 110         
Thr Arg Leu Trp Leu Ser Glu Met Thr Ser Gly Thr Thr Asn Lys His
        115                 120                 125             
Thr Leu Thr Lys Ile Tyr Asn Pro Lys Leu Asn Val Ser Glu Val Thr
    130                 135                 140                 
Leu Glu Leu Tyr Tyr Glu Lys Gly Thr Gly Ser Ala Thr Phe Asp Asn
145                 150                 155                 160 
Ile Ser Met Lys Ala Lys Gly Pro Lys Asp Ser Glu His Pro Gln Pro
                165                 170                 175     
Val Thr Thr Gln Ile Glu Glu Ser Val Asn Thr Ala Leu Asn Lys Asn
            180                 185                 190         
Tyr Val Phe Asn Lys Ala Asp Tyr Gln Tyr Thr Leu Thr Asn Pro Ser
        195                 200                 205             
Leu Gly Lys Ile Val Gly Gly Ile Leu Tyr Pro Asn Ala Thr Gly Ser
    210                 215                 220                 
Thr Thr Val Lys Ile Ser Asp Lys Ser Gly Lys Ile Ile Lys Glu Val
225                 230                 235                 240 
Pro Leu Ser Val Thr Ala Ser Thr Glu Asp Lys Phe Thr Lys Leu Leu
                245                 250                 255     
Asp Lys Trp Asn Asp Val Thr Ile Gly Asn His Val Tyr Asp Thr Asn
            260                 265                 270         
Asp Ser Asn Met Gln Lys Ile Asn Gln Lys Leu Asp Glu Thr Asn Ala
        275                 280                 285             
Lys Asn Ile Lys Thr Ile Lys Leu Asp Ser Asn His Thr Phe Leu Trp
    290                 295                 300                 
Lys Asp Leu Asp Asn Leu Asn Asn Ser Ala Gln Leu Thr Ala Thr Tyr
305                 310                 315                 320 
Arg Arg Leu Glu Asp Leu Ala Lys Gln Ile Thr Asn Pro His Ser Thr
                325                 330                 335     
Ile Tyr Lys Asn Glu Lys Ala Ile Arg Thr Val Lys Glu Ser Leu Ala
            340                 345                 350         
Trp Leu His Gln Asn Phe Tyr Asn Val Asn Lys Asp Ile Glu Gly Ser
        355                 360                 365             
Ala Asn Trp Trp Asp Phe Glu Ile Gly Val Pro Arg Ser Ile Thr Ala
    370                 375                 380                 
Thr Leu Ala Leu Met Asn Asn Tyr Phe Thr Asp Ala Glu Ile Lys Thr
385                 390                 395                 400 
Tyr Thr Asp Pro Ile Glu His Phe Val Pro Asp Ala Gly Tyr Phe Arg
                405                 410                 415     
Lys Thr Leu Asp Asn Pro Phe Lys Ala Leu Gly Gly Asn Leu Val Asp
            420                 425                 430         
Met Gly Arg Val Lys Ile Ile Glu Gly Leu Leu Arg Lys Asp Asn Thr
        435                 440                 445             
Ile Ile Glu Lys Thr Ser His Ser Leu Lys Asn Leu Phe Thr Thr Ala
    450                 455                 460                 
Thr Lys Ala Glu Gly Phe Tyr Ala Asp Gly Ser Tyr Ile Asp His Thr
465                 470                 475                 480 
Asn Val Ala Tyr Thr Gly Ala Tyr Gly Asn Val Leu Ile Asp Gly Leu
                485                 490                 495     
Thr Gln Leu Leu Pro Ile Ile Gln Glu Thr Asp Tyr Lys Ile Ser Asn
            500                 505                 510         
Gln Glu Leu Asp Met Val Tyr Lys Trp Ile Asn Gln Ser Phe Leu Pro
        515                 520                 525             
Leu Ile Val Lys Gly Glu Leu Met Asp Met Ser Arg Gly Arg Ser Ile
    530                 535                 540                 
Ser Arg Glu Ala Ala Ser Ser His Ala Ala Ala Val Glu Val Leu Arg
545                 550                 555                 560 
Gly Phe Leu Arg Leu Ala Asn Met Ser Asn Glu Glu Arg Asn Leu Asp
                565                 570                 575     
Leu Lys Ser Thr Ile Lys Thr Ile Ile Thr Ser Asn Lys Phe Tyr Asn
            580                 585                 590         
Val Phe Asn Asn Leu Lys Ser Tyr Ser Asp Ile Ala Asn Met Asn Lys
        595                 600                 605             
Met Leu Asn Asp Ser Thr Val Ala Thr Lys Pro Leu Lys Ser Asn Leu
    610                 615                 620                 
Ser Thr Phe Asn Ser Met Asp Arg Leu Ala Tyr Tyr Asn Ala Glu Lys
625                 630                 635                 640 
Asp Phe Gly Phe Ala Leu Ser Leu His Ser Lys Arg Thr Leu Asn Tyr
                645                 650                 655     
Glu Gly Met Asn Asp Glu Asn Thr Arg Asp Trp Tyr Thr Gly Asp Gly
            660                 665                 670         
Met Phe Tyr Leu Tyr Asn Ser Asp Gln Ser His Tyr Ser Asn His Phe
        675                 680                 685             
Trp Pro Thr Val Asn Pro Tyr Lys Met Ala Gly Thr Thr Glu Lys Asp
    690                 695                 700                 
Ala Lys Arg Glu Asp Thr Thr Lys Glu Phe Met Ser Lys His Ser Lys
705                 710                 715                 720 
Asp Ala Lys Glu Lys Thr Gly Gln Val Thr Gly Thr Ser Asp Phe Val
                725                 730                 735     
Gly Ser Val Lys Leu Asn Asp His Phe Ala Leu Ala Ala Met Asp Phe
            740                 745                 750         
Thr Asn Trp Asp Arg Thr Leu Thr Ala Gln Lys Gly Trp Val Ile Leu
        755                 760                 765             
Asn Asp Lys Ile Val Phe Leu Gly Ser Asn Ile Lys Asn Thr Asn Gly
    770                 775                 780                 
Ile Gly Asn Val Ser Thr Thr Ile Asp Gln Arg Lys Asp Asp Ser Lys
785                 790                 795                 800 
Thr Pro Tyr Thr Thr Tyr Val Asn Gly Lys Thr Ile Asp Leu Lys Gln
                805                 810                 815     
Ala Ser Ser Gln Gln Phe Thr Asp Thr Lys Ser Val Phe Leu Glu Ser
            820                 825                 830         
Lys Glu Pro Gly Arg Asn Ile Gly Tyr Ile Phe Phe Lys Asn Ser Thr
        835                 840                 845             

Ile Asp Ile Glu Arg Lys Glu Gln Thr Gly Thr Trp Asn Ser Ile Asn
    850                 855                 860                 
Arg Thr Ser Lys Asn Thr Ser Ile Val Ser Asn Pro Phe Ile Thr Ile
865                 870                 875                 880 
Ser Gln Lys His Asp Asn Lys Gly Asp Ser Tyr Gly Tyr Met Met Val
                885                 890                 895     
Pro Asn Ile Asp Arg Thr Ser Phe Asp Lys Leu Ala Asn Ser Lys Glu
            900                 905                 910         
Val Glu Leu Leu Glu Asn Ser Ser Lys Gln Gln Val Ile Tyr Asp Lys
        915                 920                 925             
Asn Ser Gln Thr Trp Ala Val Ile Lys His Asp Asn Gln Glu Ser Leu
    930                 935                 940                 
Ile Asn Asn Gln Phe Lys Met Asn Lys Ala Gly Leu Tyr Leu Val Gln
945                 950                 955                 960 
Lys Val Gly Asn Asp Tyr Gln Asn Val Tyr Tyr Gln Pro Gln Thr Met
                965                 970                 975     
Thr Lys Thr Asp Gln Leu Ala Ile
            980                 


<210> 282
<211> 807
<212> PRT
<213> Staphylococcus aureus (strain COL)

<220> 
<223> hyaluronan lyase

<400> 282
Met Thr Tyr Arg Ile Lys Lys Trp Gln Lys Leu Ser Thr Ile Thr Leu
 1               5                  10                  15      
Leu Met Ala Gly Val Ile Thr Leu Asn Gly Gly Glu Phe Arg Ser Val
            20                  25                  30          
Asp Lys His Gln Ile Ala Val Ala Asp Thr Asn Val Gln Thr Pro Asp
        35                  40                  45              
Tyr Glu Lys Leu Arg Asn Thr Trp Leu Asp Val Asn Tyr Gly Tyr Asp
    50                  55                  60                  
Lys Tyr Asp Glu Asn Asn Pro Asp Met Lys Lys Lys Phe Asp Ala Thr
65                  70                  75                  80  
Glu Lys Glu Ala Thr Asn Leu Leu Lys Glu Met Lys Thr Glu Ser Gly
                85                  90                  95      
Arg Lys Tyr Leu Trp Ser Gly Ala Glu Thr Leu Glu Thr Asn Ser Ser
            100                 105                 110         
His Met Thr Arg Thr Tyr Arg Asn Ile Glu Lys Ile Ala Glu Ala Met
        115                 120                 125             
Arg Asn Pro Lys Thr Thr Leu Asn Thr Asp Glu Asn Lys Lys Lys Val
    130                 135                 140                 
Lys Asp Ala Leu Glu Trp Leu His Lys Asn Ala Tyr Gly Lys Glu Pro
145                 150                 155                 160 
Asp Lys Lys Val Lys Glu Leu Ser Glu Asn Phe Thr Lys Thr Thr Gly
                165                 170                 175     
Lys Asn Thr Asn Leu Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro Lys
            180                 185                 190         
Ser Leu Thr Asn Thr Leu Ile Leu Leu Asn Asp Gln Phe Ser Asn Glu
        195                 200                 205             
Glu Lys Lys Lys Phe Thr Ala Pro Ile Lys Thr Phe Ala Pro Asp Ser
    210                 215                 220                 
Asp Lys Ile Leu Ser Ser Val Gly Lys Ala Glu Leu Ala Lys Gly Gly
225                 230                 235                 240 
Asn Leu Val Asp Ile Ser Lys Val Lys Leu Leu Glu Cys Ile Ile Glu
                245                 250                 255     
Glu Asp Lys Asp Met Met Lys Lys Ser Ile Asp Ser Phe Asn Lys Val
            260                 265                 270         
Phe Thr Tyr Val Gln Asp Ser Ala Thr Gly Lys Glu Arg Asn Gly Phe
        275                 280                 285             
Tyr Lys Asp Gly Ser Tyr Ile Asp His Gln Asp Val Pro Tyr Thr Gly
    290                 295                 300                 
Ala Tyr Gly Val Val Leu Leu Glu Gly Ile Ser Gln Met Met Pro Met
305                 310                 315                 320 
Ile Lys Glu Thr Pro Phe Asn Asp Lys Thr Gln Asn Asp Thr Thr Leu
                325                 330                 335     
Lys Ser Trp Ile Asp Asp Gly Phe Met Pro Leu Ile Tyr Lys Gly Glu
            340                 345                 350         
Met Met Asp Leu Ser Arg Gly Arg Ala Ile Ser Arg Glu Asn Glu Thr
        355                 360                 365             
Ser His Ser Ala Ser Ala Thr Val Met Lys Ser Leu Leu Arg Leu Ser
    370                 375                 380                 
Asp Ala Met Asp Asp Ser Thr Lys Ala Lys Tyr Lys Lys Ile Val Lys
385                 390                 395                 400 
Ser Ser Val Glu Ser Asp Ser Ser Tyr Lys Gln Asn Asp Tyr Leu Asn
                405                 410                 415     
Ser Tyr Ser Asp Ile Asp Lys Met Lys Ser Leu Met Thr Asp Asn Ser
            420                 425                 430         
Ile Ser Lys Asn Gly Leu Thr Gln Gln Leu Lys Ile Tyr Asn Asp Met
        435                 440                 445             
Asp Arg Val Thr Tyr His Asn Lys Asp Leu Asp Phe Ala Phe Gly Leu
    450                 455                 460                 
Ser Met Thr Ser Lys Asn Val Ala Arg Tyr Glu Ser Ile Asn Gly Glu
465                 470                 475                 480 
Asn Leu Lys Gly Trp His Thr Gly Ala Gly Met Ser Tyr Leu Tyr Asn
                485                 490                 495     
Ser Asp Val Lys His Tyr His Asp Asn Phe Trp Val Thr Ala Asp Met
            500                 505                 510         
Lys Arg Leu Ser Gly Thr Thr Thr Leu Asp Asn Glu Ile Leu Lys Asp
        515                 520                 525             
Thr Asp Asp Lys Lys Ser Ser Lys Thr Phe Val Gly Gly Thr Lys Val
    530                 535                 540                 
Asp Asp Gln His Ala Ser Ile Gly Met Asp Phe Glu Asn Gln Asp Lys
545                 550                 555                 560 
Thr Leu Thr Ala Lys Lys Ser Tyr Phe Ile Leu Asn Asp Lys Ile Val
                565                 570                 575     
Phe Leu Gly Thr Gly Ile Lys Ser Thr Asp Ser Ser Lys Asn Pro Val
            580                 585                 590         
Thr Thr Ile Glu Asn Arg Lys Ala Asn Gly Tyr Thr Leu Tyr Thr Asp
        595                 600                 605             
Asp Lys Gln Thr Thr Asn Ser Asp Asn Gln Glu Asn Asn Ser Val Phe
    610                 615                 620                 
Leu Glu Ser Thr Asp Thr Lys Lys Asn Ile Gly Tyr His Phe Leu Asn
625                 630                 635                 640 
Lys Pro Lys Ile Thr Val Lys Lys Glu Ser His Thr Gly Lys Trp Lys
                645                 650                 655     
Glu Ile Asn Lys Ser Gln Lys Asp Thr Gln Lys Thr Asp Glu Tyr Tyr
            660                 665                 670         
Glu Val Thr Gln Lys His Ser Asn Ser Asp Asn Lys Tyr Gly Tyr Val
        675                 680                 685             
Leu Tyr Pro Gly Leu Ser Lys Asp Val Phe Lys Thr Lys Lys Asp Glu
    690                 695                 700                 
Val Thr Val Val Lys Gln Glu Asp Asp Phe His Val Val Lys Asp Asn
705                 710                 715                 720 
Glu Ser Val Trp Ala Gly Val Asn Tyr Ser Asn Ser Thr Gln Thr Phe
                725                 730                 735     
Asp Ile Asn Asn Thr Lys Val Glu Val Lys Ala Lys Gly Met Phe Ile
            740                 745                 750         
Leu Lys Lys Lys Asp Asp Asn Thr Tyr Glu Cys Ser Phe Tyr Asn Pro
        755                 760                 765             
Glu Ser Thr Asn Ser Ala Ser Asp Ile Glu Ser Lys Ile Ser Met Thr
    770                 775                 780                 
Gly Tyr Ser Ile Thr Asn Lys Asn Thr Ser Thr Ser Asn Glu Ser Gly
785                 790                 795                 800 
Val His Phe Glu Leu Thr Lys
                805         


<210> 283
<211> 420
<212> PRT
<213> Staphylococcus aureus (strain MRSA252)

<220> 
<223> hyaluronan lyase

<400> 283
Met Thr Tyr Arg Met Lys Lys Trp Gln Lys Leu Ser Thr Ile Thr Leu
 1               5                  10                  15      
Leu Met Ala Gly Val Ile Thr Leu Asn Gly Gly Glu Phe Arg Ser Ile
            20                  25                  30          
Asp Lys His Gln Ile Ala Val Ala Asp Thr Asn Val Gln Thr Thr Asp
        35                  40                  45              
Tyr Glu Lys Leu Arg Asn Ile Trp Leu Asp Val Asn Tyr Gly Tyr Asp
    50                  55                  60                  
Lys Tyr Asp Glu Asn Asn Pro Asp Met Lys Lys Lys Phe Glu Ala Thr
65                  70                  75                  80  
Glu Asn Glu Ala Glu Lys Leu Leu Lys Glu Met Lys Thr Glu Ser Asp
                85                  90                  95      
Arg Lys Tyr Leu Trp Glu Ser Ser Lys Asp Leu Asp Thr Lys Ser Ala
            100                 105                 110         
Asp Met Thr Arg Thr Tyr Arg Asn Ile Glu Lys Ile Ser Glu Ala Met
        115                 120                 125             
Lys His Lys Asn Thr Lys Leu Lys Thr Asp Glu Asn Lys Thr Lys Val
    130                 135                 140                 
Lys Asp Ala Leu Glu Trp Leu His Lys Asn Ala Tyr Gly Lys Glu Pro
145                 150                 155                 160 
Asp Lys Lys Val Ala Asp Leu Thr Ser Asn Phe Lys Asn Lys Thr Ser
                165                 170                 175     
Arg Asn Thr Asn Leu Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro Arg
            180                 185                 190         
Ala Leu Thr Asn Thr Leu Ile Leu Leu Gln Glu Asp Phe Thr Asp Glu
        195                 200                 205             
Glu Lys Lys Lys Tyr Thr Ala Pro Ile Lys Thr Phe Ala Pro Asp Ser
    210                 215                 220                 
Asp Lys Ile Leu Ser Ser Val Gly Lys Ser Glu Pro Ala Lys Gly Gly
225                 230                 235                 240 
Asn Leu Val Asp Ile Ser Lys Val Lys Leu Leu Glu Ser Ile Ile Glu
                245                 250                 255     
Glu Asp Lys Asp Met Met Lys Lys Ser Ile Asp Ser Phe Asn Thr Val
            260                 265                 270         
Phe Thr Tyr Ala Gln Asn Ser Ala Thr Gly Lys Glu Arg Asn Gly Phe
        275                 280                 285             
Tyr Lys Asp Gly Ser Tyr Ile Asp His Gln Asp Val Pro Tyr Thr Gly
    290                 295                 300                 
Ala Tyr Gly Val Val Leu Leu Glu Gly Ile Ser Gln Met Met Pro Met
305                 310                 315                 320 
Ile Lys Glu Thr Pro Phe Asn Asp Ser Asn Gln Asn Asp Thr Thr Leu
                325                 330                 335     
Lys Ser Trp Ile Asp Asp Gly Phe Met Pro Leu Ile Tyr Lys Gly Glu
            340                 345                 350         
Met Met Asp Leu Ser Arg Gly Arg Ala Ile Ser Arg Glu Asn Glu Thr
        355                 360                 365             
Ser His Ser Ala Ser Ala Thr Val Met Lys Ser Leu Leu Arg Leu Ser
    370                 375                 380                 
Asp Thr Met Asp Lys Ser Thr Lys Ala Lys Tyr Lys Lys Ile Val Lys
385                 390                 395                 400 
Thr Ser Val Glu Ser Asp Ser Ser Tyr Lys Gln Thr Asp Tyr Leu Ser
                405                 410                 415     
Ser Tyr Ser Asp
            420 


<210> 284
<211> 806
<212> PRT
<213> Staphylococcus aureus (strain MRSA252)

<220> 
<223> hyaluronan lyase

<400> 284
Met Thr Asn Lys Met Lys Lys Trp Gln Lys Leu Ser Thr Ile Thr Leu
 1               5                  10                  15      
Leu Met Thr Gly Val Ile Ala Leu Asn Asn Gly Glu Phe Arg Asn Val
            20                  25                  30          
Asp Lys His Gln Ile Ala Val Ala Asp Thr Asn Val Gln Thr Pro Asp
        35                  40                  45              
Tyr Glu Lys Leu Lys Lys Thr Trp Leu Asp Val Asn Tyr Gly Tyr Asp
    50                  55                  60                  
Gln Tyr Asp Glu Asn Asn Gln Asp Met Lys Lys Lys Phe Asp Ala Lys
65                  70                  75                  80  
Glu Lys Glu Ala Lys Lys Leu Leu Asp Asp Met Lys Thr Asp Thr Asn
                85                  90                  95      
Arg Thr Tyr Leu Trp Ser Gly Ala Glu Asn Leu Glu Thr Asn Ser Ser
            100                 105                 110         
His Met Thr Lys Thr Tyr Arg Asn Ile Glu Lys Ile Ala Glu Ser Met
        115                 120                 125             
Gln His Lys Asn Thr Val Leu Lys Thr Val Glu Asn Lys Leu Lys Ile
    130                 135                 140                 
Lys Glu Ala Leu Asp Trp Met His Lys Asn Val Tyr Gly Lys Asn Pro
145                 150                 155                 160 
Ser Gln Lys Val Glu Asp Leu Thr Lys Asn Arg Lys Gly Gln Thr Thr
                165                 170                 175     
Pro Lys Asn Asn Ser Leu Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro
            180                 185                 190         
Arg Ala Leu Thr Asn Thr Leu Leu Leu Met Asp Asp Met Leu Thr Lys
        195                 200                 205             
Asp Glu Met Lys Asn Tyr Ser Lys Pro Ile Ser Thr Tyr Ala Pro Ser
    210                 215                 220                 
Ser Asp Lys Ile Leu Ser Ser Val Gly Glu Ser Glu Asp Ala Lys Gly
225                 230                 235                 240 
Gly Asn Leu Val Asp Ile Ser Lys Val Lys Leu Leu Glu Ser Val Ile
                245                 250                 255     
Glu Glu Asp Val Asp Met Leu Lys Lys Ser Ile Asp Ser Phe Asn Lys
            260                 265                 270         
Val Phe Thr Tyr Val Gln Asp Ser Ala Thr Gly Lys Gly Arg Asn Gly
        275                 280                 285             
Phe Tyr Lys Asp Gly Ser Tyr Ile Asp His Gln Asp Val Pro Tyr Thr
    290                 295                 300                 
Gly Ala Tyr Gly Val Val Leu Leu Glu Gly Ile Ser Gln Met Met Pro
305                 310                 315                 320 
Met Ile Lys Glu Ser Pro Phe Lys Thr Thr Gln Asp Asn Ala Thr Leu
                325                 330                 335     
Ser Asn Trp Ile Asp Glu Gly Phe Met Pro Leu Ile Tyr Lys Gly Glu
            340                 345                 350         
Met Met Asp Leu Ser Arg Gly Arg Ala Ile Ser Arg Glu Asn Glu Thr
        355                 360                 365             
Ser His Thr Ala Ser Ala Thr Val Met Lys Ser Leu Leu Arg Leu Asn
    370                 375                 380                 
Asp Thr Met Asp Asp Ser Thr Lys Thr Arg Tyr Lys Gln Ile Val Lys
385                 390                 395                 400 
Thr Ser Val Asn Ser Asp Ser Ser Tyr Asn Gln Asn Asn Tyr Leu Asn
                405                 410                 415     
Ser Tyr Ser Asp Ile Ala Lys Met Lys Lys Leu Met Asn Asp Ser Thr
            420                 425                 430         
Ile Ser Lys Asn Asp Leu Thr Gln Gln Leu Lys Ile Tyr Asn Asp Met
        435                 440                 445             
Asp Arg Val Thr Tyr His Asn Lys Asp Leu Asp Phe Ala Phe Gly Leu
    450                 455                 460                 
Ser Met Thr Ser Lys Asn Ile Ala Arg Tyr Glu Asn Ile Asn Gly Glu
465                 470                 475                 480 
Asn Leu Lys Gly Trp His Thr Gly Ala Gly Met Ser Tyr Leu Tyr Asn
                485                 490                 495     
Ser Asp Val Lys His Tyr Arg Asp Asn Phe Trp Ala Thr Ala Asp Met
            500                 505                 510         
Thr Cys Leu Pro Gly Thr Thr Thr Leu Asn Asp Met Pro Ser Thr Asn
        515                 520                 525             
Thr Lys Asn Asp Lys Ser Phe Val Gly Gly Thr Lys Leu Asn Asn Lys
    530                 535                 540                 
Tyr Ala Ser Ile Gly Met Asp Phe Glu Asn Gln Asp Lys Thr Leu Thr
545                 550                 555                 560 
Ala Lys Lys Ser Tyr Phe Ile Leu Asn Asp Lys Ile Val Phe Leu Gly
                565                 570                 575     
Thr Gly Ile Lys Ser Thr Asp Ser Ser Lys Asn Pro Val Thr Ser Val
            580                 585                 590         
Glu Asn Arg Lys Ala Asn Gly Tyr Lys Leu Phe Lys Asp Asp Ile Glu
        595                 600                 605             
Ile Thr Thr Ser Asp Val Asn Ala Gln Glu Thr His Ser Val Phe Leu
    610                 615                 620                 
Glu Ser Asn Asp Thr Lys Lys Asn Ile Gly Tyr His Phe Leu Asp Lys
625                 630                 635                 640 
Pro Lys Ile Thr Val Lys Lys Glu Ser His Thr Gly Lys Trp Ser Glu
                645                 650                 655     
Ile Asn Lys Ser Gln Lys Lys Asp Asp Lys Lys Asp Glu Tyr Tyr Glu
            660                 665                 670         
Val Thr Gln Thr His Asn Thr Ser Asp Ser Lys Tyr Ala Tyr Val Leu
        675                 680                 685             
Tyr Pro Gly Leu Ser Lys Ser Asp Phe Lys Ser Lys Asn Asn Asn Val
    690                 695                 700                 
Ser Ile Val Lys Gln Asp Glu Asp Phe His Val Ile Lys Asp Asn Asp
705                 710                 715                 720 
Gly Val Phe Ala Gly Val Asn Tyr Ser Asp Asn Thr Lys Ser Phe Asp
                725                 730                 735     
Ile Asn Gly Ile Thr Val Glu Leu Lys Glu Lys Gly Met Phe Val Ile
            740                 745                 750         
Lys Lys Lys Asp Asp Lys Ala Tyr Lys Cys Ser Phe Tyr Asn Pro Glu
        755                 760                 765             
Thr Thr Asn Thr Ala Ser Asn Ile Glu Ser Lys Ile Phe Ile Lys Gly
    770                 775                 780                 
Tyr Thr Ile Thr Asn Lys Ser Val Ile Asn Ser Asn Asp Ala Gly Val
785                 790                 795                 800 
Asn Phe Glu Leu Thr Lys
                805     


<210> 285
<211> 815
<212> PRT
<213> Staphylococcus aureus (strain MSSA476)

<220> 
<223> hyaluronan lyase

<400> 285
Met Thr Tyr Arg Ile Lys Lys Trp Gln Lys Leu Ser Thr Ile Thr Leu
 1               5                  10                  15      
Leu Met Ala Gly Val Ile Thr Leu Asn Gly Gly Glu Phe Arg Ser Ile
            20                  25                  30          
Asp Lys Tyr Gln Ile Ala Val Ala Asp Thr Asn Val Gln Thr Pro Asp
        35                  40                  45              
Tyr Glu Lys Leu Arg Asn Thr Trp Leu Asp Val Asn Tyr Gly Tyr Asp
    50                  55                  60                  
Lys Tyr Asp Glu Lys Asn Asp Ala Met Lys Lys Lys Phe Glu Ala Thr
65                  70                  75                  80  
Glu Asn Glu Ala Lys Lys Leu Leu Ser Glu Met Lys Thr Glu Ser Asp
                85                  90                  95      
Arg Lys Tyr Leu Trp Glu Asn Ser Lys Asp Leu Asp Thr Lys Ser Ala
            100                 105                 110         
Asp Met Thr Arg Thr Tyr Arg Asn Ile Glu Lys Ile Ala Glu Ala Met
        115                 120                 125             
Lys His Lys Asp Thr Lys Leu Lys Ile Asp Glu Asn Lys Lys Lys Val
    130                 135                 140                 
Lys Asp Ala Leu Glu Trp Leu His Lys Asn Ala Tyr Gly Lys Glu Pro
145                 150                 155                 160 
Asp Lys Lys Val Ala Asp Leu Thr Ser Asn Phe Lys Asn Lys Thr Ser
                165                 170                 175     
Arg Asn Thr Asn Leu Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro Arg
            180                 185                 190         
Ala Leu Thr Asn Thr Leu Ile Leu Leu Asn Asp Gln Phe Ser Asn Asp
        195                 200                 205             
Glu Lys Lys Lys Tyr Thr Ala Pro Ile Lys Thr Phe Ala Pro Glu Ser
    210                 215                 220                 
Asp Lys Ile Leu Ser Ser Val Gly Gln Pro Glu Gln Ala Lys Gly Gly
225                 230                 235                 240 
Asn Leu Val Asp Ile Ala Lys Val Lys Leu Leu Glu Ser Ile Ile Glu
                245                 250                 255     
Glu Asp Lys Asp Ile Thr Lys Asn Ser Ile Asp Ala Phe Asn Lys Val
            260                 265                 270         
Phe Thr Tyr Val Gln Ser Asn Ala Thr Gly Lys Glu Arg Asn Gly Phe
        275                 280                 285             
Tyr Lys Asp Gly Ser Tyr Ile Asp His Gln Asp Val Pro Tyr Thr Gly
    290                 295                 300                 
Ala Tyr Gly Val Val Leu Leu Glu Gly Ile Ser Gln Met Met Pro Met
305                 310                 315                 320 
Ile Lys Glu Thr Pro Phe Asn Asp Lys Thr Gln Asn Asp Thr Thr Leu
                325                 330                 335     
Lys Ser Trp Ile Asp Asp Gly Phe Met Pro Leu Ile Tyr Lys Gly Glu
            340                 345                 350         
Met Met Asp Leu Ser Arg Gly Arg Ala Ile Ser Arg Glu Asn Glu Thr
        355                 360                 365             
Ser His Thr Ala Ser Ala Thr Val Met Lys Ser Leu Leu Arg Leu Ser
    370                 375                 380                 
Asp Ala Met Asp Asp Ser Thr Lys Ala Lys Tyr Lys Gln Ile Val Lys
385                 390                 395                 400 
Thr Ser Val Lys Ser Asp Ser Ser Tyr Gly Gln Asn Asp Thr Leu Ser
                405                 410                 415     
Ser Tyr Ser Asp Ile Ser Lys Met Lys Ser Leu Met Glu Asp Ser Thr
            420                 425                 430         
Ile Ser Thr Asn Gly Leu Thr Gln Gln Leu Lys Ile Tyr Asn Asp Met
        435                 440                 445             
Asp Arg Val Thr Tyr His Asn Lys Asp Leu Asp Phe Ala Phe Gly Leu
    450                 455                 460                 
Ser Met Thr Ser Lys Asn Val Ala Arg Tyr Glu Ser Ile Asn Gly Glu
465                 470                 475                 480 
Asn Leu Lys Gly Trp His Thr Gly Ala Gly Met Ser Tyr Leu Tyr Asn
                485                 490                 495     
Ser Asp Val Lys His Tyr Arg Asp Asn Phe Trp Ala Thr Ala Asp Met
            500                 505                 510         
Lys Arg Leu Ala Gly Thr Thr Thr Leu Glu Asn Glu Glu Pro Lys Gly
        515                 520                 525             
Thr Asp Val Lys Lys Ser Ser Lys Thr Phe Val Gly Gly Thr Lys Phe
    530                 535                 540                 
Asp Asp Gln His Ala Ser Ile Gly Met Asp Phe Glu Asn Gln Asp Lys
545                 550                 555                 560 
Thr Leu Thr Ala Lys Lys Ser Tyr Phe Ile Leu Asn Asp Lys Ile Val
                565                 570                 575     
Phe Leu Gly Thr Gly Ile Lys Ser Thr Asp Ser Ser Lys Asn Pro Val
            580                 585                 590         
Thr Thr Ile Glu Asn Arg Lys Ala Asn Gly Tyr Thr Leu Tyr Thr Asp
        595                 600                 605             
Asp Lys Gln Thr Thr Ala Ser Asp Asn Gln Gly Thr Asn Ser Val Phe
    610                 615                 620                 
Leu Glu Ser Thr Asn Lys Pro Lys Asn Asn Ile Gly Tyr His Phe Leu
625                 630                 635                 640 
Asn Glu Ser Lys Ile Thr Val Lys Lys Glu Ser His Thr Gly Lys Trp
                645                 650                 655     
Ser Asp Ile Asn Lys Ser Gln Lys Gln Asp Ser Lys Thr Asn Gln Tyr
            660                 665                 670         
Tyr Glu Val Thr Gln Lys His Ser Asn Thr Asp Ser Lys Tyr Ala Tyr
        675                 680                 685             
Val Leu Tyr Pro Gly Leu Ser Lys Asp Asp Phe Asn Thr Lys Lys Asp
    690                 695                 700                 
Lys Val Thr Val Val Lys Gln Asp Asp Asp Phe His Val Val Lys Asp
705                 710                 715                 720 
Asn Glu Ser Val Trp Ala Gly Val Asn Tyr Ser Asp Ser Thr Gln Thr
                725                 730                 735     
Phe Ile Ile Asn Asn Thr Lys Val Glu Val Lys Ala Lys Gly Met Phe
            740                 745                 750         
Ile Leu Lys Lys Lys Asp Asp Lys Thr Tyr Glu Cys Ser Phe Tyr Asn
        755                 760                 765             
Pro Glu Ser Thr Asn Thr Ala Ser Asp Ile Glu Ser Lys Ile Ser Met
    770                 775                 780                 
Thr Gly Tyr Ser Ile Thr Asn Lys Asn Thr Ser Thr Ser Asn Glu Ser
785                 790                 795                 800 
Gly Val Arg Phe Glu Leu Gln Gln Thr Leu Asn Lys Asp Asp Asn
                805                 810                 815 


<210> 286
<211> 807
<212> PRT
<213> Staphylococcus aureus (strain NCTC 8325)

<220> 
<223> hyaluronan lyase

<400> 286
Met Thr Tyr Arg Ile Lys Lys Trp Gln Lys Leu Ser Thr Ile Thr Leu
 1               5                  10                  15      
Leu Met Ala Gly Val Ile Thr Leu Asn Gly Gly Glu Phe Arg Ser Val
            20                  25                  30          
Asp Lys His Gln Ile Ala Val Ala Asp Thr Asn Val Gln Thr Pro Asp
        35                  40                  45              
Tyr Glu Lys Leu Arg Asn Thr Trp Leu Asp Val Asn Tyr Gly Tyr Asp
    50                  55                  60                  
Lys Tyr Asp Glu Asn Asn Pro Asp Met Lys Lys Lys Phe Asp Ala Thr
65                  70                  75                  80  
Glu Lys Glu Ala Thr Asn Leu Leu Lys Glu Met Lys Thr Glu Ser Gly
                85                  90                  95      
Arg Lys Tyr Leu Trp Ser Gly Ala Glu Thr Leu Glu Thr Asn Ser Ser
            100                 105                 110         
His Met Thr Arg Thr Tyr Arg Asn Ile Glu Lys Ile Ala Glu Ala Met
        115                 120                 125             
Arg Asn Pro Lys Thr Thr Leu Asn Thr Asp Glu Asn Lys Lys Lys Val
    130                 135                 140                 
Lys Asp Ala Leu Glu Trp Leu His Lys Asn Ala Tyr Gly Lys Glu Pro
145                 150                 155                 160 
Asp Lys Lys Val Lys Glu Leu Ser Glu Asn Phe Thr Lys Thr Thr Gly
                165                 170                 175     
Lys Asn Thr Asn Leu Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro Lys
            180                 185                 190         
Ser Leu Thr Asn Thr Leu Ile Leu Leu Asn Asp Gln Phe Ser Asn Glu
        195                 200                 205             
Glu Lys Lys Lys Phe Thr Ala Pro Ile Lys Thr Phe Ala Pro Asp Ser
    210                 215                 220                 
Asp Lys Ile Leu Ser Ser Val Gly Lys Ala Glu Leu Ala Lys Gly Gly
225                 230                 235                 240 
Asn Leu Val Asp Ile Ser Lys Val Lys Leu Leu Glu Cys Ile Ile Glu
                245                 250                 255     
Glu Asp Lys Asp Met Met Lys Lys Ser Ile Asp Ser Phe Asn Lys Val
            260                 265                 270         
Phe Thr Tyr Val Gln Asp Ser Ala Thr Gly Lys Glu Arg Asn Gly Phe
        275                 280                 285             
Tyr Lys Asp Gly Ser Tyr Ile Asp His Gln Asp Val Pro Tyr Thr Gly
    290                 295                 300                 
Ala Tyr Gly Val Val Leu Leu Glu Gly Ile Ser Gln Met Met Pro Met
305                 310                 315                 320 
Ile Lys Glu Thr Pro Phe Asn Asp Lys Thr Gln Asn Asp Thr Thr Leu
                325                 330                 335     
Lys Ser Trp Ile Asp Asp Gly Phe Met Pro Leu Ile Tyr Lys Gly Glu
            340                 345                 350         
Met Met Asp Leu Ser Arg Gly Arg Ala Ile Ser Arg Glu Asn Glu Thr
        355                 360                 365             
Ser His Ser Ala Ser Ala Thr Val Met Lys Ser Leu Leu Arg Leu Ser
    370                 375                 380                 
Asp Ala Met Asp Asp Ser Thr Lys Ala Lys Tyr Lys Lys Ile Val Lys
385                 390                 395                 400 
Ser Ser Val Glu Ser Asp Ser Ser Tyr Lys Gln Asn Asp Tyr Leu Asn
                405                 410                 415     
Ser Tyr Ser Asp Ile Asp Lys Met Lys Ser Leu Met Thr Asp Asn Ser
            420                 425                 430         
Ile Ser Lys Asn Gly Leu Thr Gln Gln Leu Lys Ile Tyr Asn Asp Met
        435                 440                 445             
Asp Arg Val Thr Tyr His Asn Lys Asp Leu Asp Phe Ala Phe Gly Leu
    450                 455                 460                 
Ser Met Thr Ser Lys Asn Val Ala Arg Tyr Glu Ser Ile Asn Gly Glu
465                 470                 475                 480 
Asn Leu Lys Gly Trp His Thr Gly Ala Gly Met Ser Tyr Leu Tyr Asn
                485                 490                 495     
Ser Asp Val Lys His Tyr His Asp Asn Phe Trp Val Thr Ala Asp Met
            500                 505                 510         
Lys Arg Leu Ser Gly Thr Thr Thr Leu Asp Asn Glu Ile Leu Lys Asp
        515                 520                 525             
Thr Asp Asp Lys Lys Ser Ser Lys Thr Phe Val Gly Gly Thr Lys Val
    530                 535                 540                 
Asp Asp Gln His Ala Ser Ile Gly Met Asp Phe Glu Asn Gln Asp Lys
545                 550                 555                 560 
Thr Leu Thr Ala Lys Lys Ser Tyr Phe Ile Leu Asn Asp Lys Ile Val
                565                 570                 575     
Phe Leu Gly Thr Gly Ile Lys Ser Thr Asp Ser Ser Lys Asn Pro Val
            580                 585                 590         
Thr Thr Ile Glu Asn Arg Lys Ala Asn Gly Tyr Thr Leu Tyr Thr Asp
        595                 600                 605             
Asp Lys Gln Thr Thr Asn Ser Asp Asn Gln Glu Asn Asn Ser Val Phe
    610                 615                 620                 
Leu Glu Ser Thr Asp Thr Lys Lys Asn Ile Gly Tyr His Phe Leu Asn
625                 630                 635                 640 
Lys Pro Lys Ile Thr Val Lys Lys Glu Ser His Thr Gly Lys Trp Lys
                645                 650                 655     
Glu Ile Asn Lys Ser Gln Lys Asp Thr Gln Lys Thr Asp Glu Tyr Tyr
            660                 665                 670         
Glu Val Thr Gln Lys His Ser Asn Ser Asp Asn Lys Tyr Gly Tyr Val
        675                 680                 685             
Leu Tyr Pro Gly Leu Ser Lys Asp Val Phe Lys Thr Lys Lys Asp Glu
    690                 695                 700                 
Val Thr Val Val Lys Gln Glu Asp Asp Phe His Val Val Lys Asp Asn
705                 710                 715                 720 
Glu Ser Val Trp Ala Gly Val Asn Tyr Ser Asn Ser Thr Gln Thr Phe
                725                 730                 735     
Asp Ile Asn Asn Thr Lys Val Glu Val Lys Ala Lys Gly Met Phe Ile
            740                 745                 750         
Leu Lys Lys Lys Asp Asp Asn Thr Tyr Glu Cys Ser Phe Tyr Asn Pro
        755                 760                 765             
Glu Ser Thr Asn Ser Ala Ser Asp Ile Glu Ser Lys Ile Ser Met Thr
    770                 775                 780                 
Gly Tyr Ser Ile Thr Asn Lys Asn Thr Ser Thr Ser Asn Glu Ser Gly
785                 790                 795                 800 
Val His Phe Glu Leu Thr Lys
                805         


<210> 287
<211> 809
<212> PRT
<213> Staphylococcus aureus (strain bovine RF122)

<220> 
<223> hyaluronan lyase

<400> 287
Met Thr Tyr Arg Met Lys Lys Trp Gln Lys Leu Ser Thr Ile Thr Leu
 1               5                  10                  15      
Leu Met Ala Gly Gly Ile Thr Phe Asn Asp Ser Glu Phe Arg Ser Val
            20                  25                  30          
Asp Lys His Gln Ile Ala Val Ala Asp Thr Asn Val Gln Thr Pro Asn
        35                  40                  45              
Tyr Glu Lys Leu Lys Asn Thr Trp Leu Asp Val Asn Tyr Gly Tyr Asp
    50                  55                  60                  
Lys Tyr Asp Glu Ser Asn Pro Asp Met Lys Lys Lys Phe Glu Ala Thr
65                  70                  75                  80  
Glu Lys Glu Ala Arg Lys Leu Leu Ser Glu Met Lys Thr Glu Ser Asp
                85                  90                  95      
Arg Lys Tyr Leu Trp Glu Asn Ser Lys Asp Leu Asp Thr Lys Ser Ala
            100                 105                 110         
Asp Met Thr Arg Thr Tyr Arg Asn Ile Glu Lys Ile Ala Glu Ala Met
        115                 120                 125             
Lys His Pro Lys Thr Thr Leu Lys Asn Asp Glu Asn Lys Lys Lys Val
    130                 135                 140                 
Lys Asp Ala Leu Glu Trp Leu His Lys Asn Ala Tyr Gly Lys Glu Pro
145                 150                 155                 160 
Gly Lys Lys Val Ala Asp Leu Lys Thr Asn Phe Ser Lys Ser Ala Pro
                165                 170                 175     
Gln Lys Asn Thr Asn Leu Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro
            180                 185                 190         
Arg Ala Leu Thr Asn Thr Leu Ile Leu Leu Lys Glu Asp Phe Thr Asp
        195                 200                 205             
Glu Glu Lys Lys Lys Tyr Thr Ala Pro Ile Lys Thr Phe Ala Pro Lys
    210                 215                 220                 
Ser Asp Glu Ile Leu Ser Ser Val Gly Lys Ala Glu Pro Ala Lys Gly
225                 230                 235                 240 
Gly Asn Leu Val Asp Ile Ser Lys Val Lys Leu Leu Glu Ser Ile Ile
                245                 250                 255     
Glu Glu Asp Lys Asp Met Met Lys Asn Ser Ile Asp Ser Phe Asn Lys
            260                 265                 270         
Val Phe Thr Tyr Val Gln Asp Ser Ala Thr Asp Lys Glu Arg Asn Gly
        275                 280                 285             
Phe Tyr Lys Asp Gly Ser Tyr Ile Asp His Lys Asp Val Pro Tyr Thr
    290                 295                 300                 
Gly Ala Tyr Gly Val Val Leu Leu Glu Gly Ile Ser Gln Met Met Pro
305                 310                 315                 320 
Met Ile Lys Glu Thr Pro Phe Asn Asp Lys Thr Gln Asn Asn Thr Thr
                325                 330                 335     
Leu Thr Ser Trp Ile Asp Asp Gly Phe Met Pro Leu Ile Tyr Lys Gly
            340                 345                 350         
Glu Met Met Asp Leu Ser Arg Gly Arg Ala Ile Ser Arg Glu Asn Glu
        355                 360                 365             
Thr Ser His Ser Ala Ser Ala Thr Val Met Lys Ser Leu Leu Arg Leu
    370                 375                 380                 
Ser Asp Ala Met Asp Glu Ser Thr Lys Ala Lys Tyr Lys Gln Ile Val
385                 390                 395                 400 
Lys Asn Ser Val Lys Ser Asp Ser Ser Tyr Gly Gln Asn Asp Thr Leu
                405                 410                 415     
Ser Ser Tyr Ser Asp Ile Asp Lys Met Lys Ser Leu Met Thr Asp Ser
            420                 425                 430         
Thr Ile Ser Thr Asn Gly Leu Thr Gln Gln Leu Lys Ile Tyr Asn Ala
        435                 440                 445             
Met Asp Arg Val Thr Tyr His Asn Lys Asp Leu Asp Phe Ala Phe Gly
    450                 455                 460                 
Leu Ser Met Thr Ser Lys Asn Val Ala Arg Tyr Glu Asn Ile Asn Gly
465                 470                 475                 480 
Glu Asn Leu Lys Gly Trp His Thr Gly Ala Gly Met Ser Tyr Leu Tyr
                485                 490                 495     
Asn Ser Asp Val Arg His Tyr Arg Asp Asn Phe Trp Ala Thr Ala Asp
            500                 505                 510         
Met Lys Arg Leu Ala Asp Thr Thr Thr Leu Glu Asn Glu Glu Pro Lys
        515                 520                 525             
Gly Thr Asp Val Lys Lys Ser Ser Lys Thr Phe Val Gly Gly Thr Lys
    530                 535                 540                 
Phe Asp Asp Gln His Ala Ser Ile Gly Met Asp Phe Glu Asn Gln Asp
545                 550                 555                 560 
Lys Thr Leu Thr Ala Lys Lys Ser Tyr Phe Ile Leu Asn Asp Lys Ile
                565                 570                 575     
Val Phe Leu Gly Thr Gly Ile Lys Thr Thr Asp Ser Ser Lys Asn Pro
            580                 585                 590         
Val Thr Thr Ile Glu Asn Arg Lys Ala His Gly Tyr Thr Leu Tyr Thr
        595                 600                 605             
Asp Asp Lys Gln Thr Thr Asn Ser Asn Asn Gln Glu Thr Asn Ser Val
    610                 615                 620                 
Phe Leu Glu Ser Thr Asn Ser Thr Gln Asn Asn Ile Gly Tyr His Phe
625                 630                 635                 640 
Leu Asn Lys Ser Lys Ile Thr Val Lys Lys Glu Ser His Thr Gly Lys
                645                 650                 655     
Trp Ser Asp Ile Asn Lys Ser Gln Lys Asp Thr Gln Lys Thr Asp Glu
            660                 665                 670         
Tyr Tyr Glu Val Thr Gln Lys His Ser Asn Thr Asp Asp Lys Tyr Ala
        675                 680                 685             
Tyr Val Leu Tyr Pro Gly Ile Thr Lys Asp Asn Phe Lys Ser Lys Ala
    690                 695                 700                 
Ser Gln Val Thr Val Val Lys Gln Asp Asp Asp Phe His Val Val Lys
705                 710                 715                 720 
Asp Asn Glu Ser Val Trp Ala Gly Val Asn Tyr Ser Asp Ser Thr Gln
                725                 730                 735     
Thr Phe Asp Ile Asn Gly Thr Lys Val Glu Val Lys Ala Lys Gly Met
            740                 745                 750         
Phe Ile Leu Lys Lys Lys Asp Asp Asn Thr Tyr Glu Cys Ser Phe Tyr
        755                 760                 765             
Asn Pro Glu Ser Thr Asn Ser Ala Ser Asp Ile Glu Ser Lys Ile Ser
    770                 775                 780                 
Met Thr Gly Tyr Ser Ile Thr Asn Lys Asn Thr Ser Asn Thr Asn Glu
785                 790                 795                 800 
Ser Gly Val Arg Phe Glu Leu Thr Lys
                805                 


<210> 288
<211> 807
<212> PRT
<213> Staphylococcus aureus (strain bovine RF122)

<220> 
<223> hyaluronan lyase

<400> 288
Met Thr Tyr Lys Met Lys Lys Trp Gln Lys Leu Ser Thr Ile Thr Leu
 1               5                  10                  15      
Leu Met Ala Gly Val Ile Thr Leu Asn Asn Gly Glu Phe Arg Asn Val
            20                  25                  30          
Asp Lys His Gln Ile Ala Val Ala Asp Thr Asn Val Gln Thr Pro Asp
        35                  40                  45              
Tyr Glu Lys Leu Lys Lys Thr Trp Leu Asp Val Asn Tyr Gly Asn Asp
    50                  55                  60                  
Gln Tyr Asp Glu Asn Asn Gln Asp Met Lys Lys Lys Phe Asp Ala Lys
65                  70                  75                  80  
Glu Asn Glu Ala Lys Lys Leu Leu Glu Asp Met Lys Thr Asp Thr Asn
                85                  90                  95      
Arg Thr Tyr Leu Trp Ser Gly Ala Glu Asn Leu Glu Thr Asn Ser Ser
            100                 105                 110         
His Met Thr Lys Thr Tyr Arg Asn Ile Glu Lys Ile Ala Glu Ala Met
        115                 120                 125             
Arg His Lys Asn Thr Ser Leu Lys Thr Asp Glu Asn Lys Leu Lys Ile
    130                 135                 140                 
Lys Asp Ala Ile Lys Trp Leu His His Asn Val Tyr Gly Lys Asp Pro
145                 150                 155                 160 
Asp Lys Lys Val Ala Asp Leu Thr Thr Asn Arg Lys Glu Lys Asp Ser
                165                 170                 175     
Ser Lys Lys Asn Asn Ser Leu Asn Trp Trp Asp Tyr Glu Ile Gly Thr
            180                 185                 190         
Pro Arg Ala Leu Thr Asn Thr Leu Leu Leu Met Asp Asn Met Leu Thr
        195                 200                 205             
Lys Asp Glu Met Lys Asn Tyr Ser Lys Pro Ile Ser Ile Tyr Ser Pro
    210                 215                 220                 
Ser Ser Tyr Lys Ile Leu Ser Ser Val Gly Glu Ser Glu Asp Ala Lys
225                 230                 235                 240 
Gly Gly Asn Leu Val Asp Ile Ala Lys Val Lys Phe Leu Glu Ser Val
                245                 250                 255     
Ile Glu Glu Asp Val Asp Met Met Lys Lys Ser Ile Asp Ser Phe Asn
            260                 265                 270         
Lys Val Phe Thr Tyr Val Gln Asp Ser Ala Thr Gly Lys Ala Arg Asn
        275                 280                 285             
Gly Phe Tyr Lys Asp Gly Ser Tyr Ile Asp His Gln Asp Val Pro Tyr
    290                 295                 300                 
Thr Gly Ala Tyr Gly Val Val Leu Leu Glu Gly Ile Ser Gln Met Met
305                 310                 315                 320 
Pro Met Ile Lys Glu Ser Pro Phe Lys His Thr Gln Asp Lys Ala Thr
                325                 330                 335     
Leu Ser Asn Trp Ile Asp Glu Gly Phe Met Pro Leu Ile Tyr Lys Gly
            340                 345                 350         
Glu Met Met Asp Leu Ser Arg Gly Arg Ala Ile Ser Arg Glu Asn Glu
        355                 360                 365             
Thr Ser His Thr Ala Ser Ala Thr Val Met Lys Ser Leu Leu Arg Leu
    370                 375                 380                 
Ser Asp Thr Met Asp Glu Ser Thr Lys Thr Lys Tyr Lys Gln Ile Val
385                 390                 395                 400 
Lys Thr Ser Val Lys Ser Asp Ser Ser Tyr Asp Ser Asn Asp Thr Leu
                405                 410                 415     
Asn Ser Tyr Ser Asp Ile Asp Lys Met Lys Lys Leu Met Asn Asp Ser
            420                 425                 430         
Thr Ile Ser Lys Asn Asp Leu Thr Gln Gln Leu Lys Ile Tyr Asn Asp
        435                 440                 445             
Met Asp Arg Val Thr Tyr His Asn Lys Glu Leu Asp Phe Ala Phe Gly
    450                 455                 460                 
Leu Ser Met Thr Ser Lys Asn Ile Ala Arg Tyr Glu Asn Ile Asn Gly
465                 470                 475                 480 
Glu Asn Leu Lys Gly Trp His Thr Gly Ala Gly Met Ser Tyr Leu Tyr
                485                 490                 495     
Asn Ser Asp Val Lys His Tyr Arg Asp Asn Phe Trp Ala Thr Ala Asp
            500                 505                 510         
Met Thr Arg Leu Pro Gly Thr Thr Thr Leu Asn Asp Met Pro Ser Thr
        515                 520                 525             
Asn Thr Lys Asn Asp Lys Ser Phe Val Gly Gly Thr Lys Leu Asn Asn
    530                 535                 540                 
Lys Tyr Ala Ser Ile Gly Met Asp Phe Glu Asn Gln Asp Lys Thr Leu
545                 550                 555                 560 
Thr Ala Lys Lys Ser Tyr Phe Ile Leu Asn Asp Lys Ile Val Phe Ile
                565                 570                 575     
Gly Thr Gly Ile Lys Ser Thr Asp Ser Ser Lys Asn Pro Val Thr Ser
            580                 585                 590         
Val Glu Asn Arg Lys Ala Asn Gly Tyr Lys Leu Phe Lys Gly Asp Ile
        595                 600                 605             
Glu Ile Thr Thr Ser Asp Val Asn Ala Gln Glu Thr His Ser Val Phe
    610                 615                 620                 
Leu Glu Ser Asn Asp Thr Lys Lys Asn Ile Gly Tyr His Phe Leu Asp
625                 630                 635                 640 
Lys Pro Lys Ile Thr Val Lys Lys Glu Ser His Thr Gly Lys Trp Ser
                645                 650                 655     
Glu Ile Asn Lys Ser Gln Lys Thr Asp Asp Lys Lys Asp Glu Tyr Tyr
            660                 665                 670         
Glu Val Thr Gln Thr His Asn Thr Ser Asp Ser Lys Tyr Ala Tyr Val
        675                 680                 685             
Leu Tyr Pro Gly Leu Ser Lys Ser Asp Phe Lys Ser Lys Asn Asn Asn
    690                 695                 700                 
Val Ser Ile Val Lys Gln Asp Glu Asp Phe His Val Ile Lys Asp Asn
705                 710                 715                 720 
Asp Gly Val Phe Ala Gly Val Asn Tyr Ser Asp Ser Thr Lys Ser Phe
                725                 730                 735     
Asp Ile Asn Gly Thr Ile Val Glu Leu Lys Glu Lys Gly Met Phe Val
            740                 745                 750         
Ile Lys Lys Lys Asp Asp Asn Thr Tyr Glu Cys Ser Phe Tyr Asn Pro
        755                 760                 765             
Thr Ser Thr Asn Ser Thr Ser Asn Lys Glu Ser Lys Ile Ser Val Thr
    770                 775                 780                 
Gly Tyr Thr Ile Thr Asn Gln Ser Val Ser Asn Phe Lys Glu Ser Asp
785                 790                 795                 800 
Ile His Phe Glu Leu Thr Lys
                805         


<210> 289
<211> 807
<212> PRT
<213> Staphylococcus aureus (strain USA300)

<220> 
<223> hyaluronan lyase

<400> 289
Met Thr Tyr Arg Ile Lys Lys Trp Gln Lys Leu Ser Thr Ile Thr Leu
 1               5                  10                  15      
Leu Met Ala Gly Val Ile Thr Leu Asn Gly Gly Glu Phe Arg Ser Val
            20                  25                  30          
Asp Lys His Gln Ile Ala Val Ala Asp Thr Asn Val Gln Thr Pro Asp
        35                  40                  45              
Tyr Glu Lys Leu Arg Asn Thr Trp Leu Asp Val Asn Tyr Gly Tyr Asp
    50                  55                  60                  
Lys Tyr Asp Glu Asn Asn Pro Asp Met Lys Lys Lys Phe Asp Ala Thr
65                  70                  75                  80  
Glu Lys Glu Ala Thr Asn Leu Leu Lys Glu Met Lys Thr Glu Ser Gly
                85                  90                  95      
Arg Lys Tyr Leu Trp Ser Gly Ala Glu Thr Leu Glu Thr Asn Ser Ser
            100                 105                 110         
His Met Thr Arg Thr Tyr Arg Asn Ile Glu Lys Ile Ala Glu Ala Met
        115                 120                 125             
Arg Asn Pro Lys Thr Thr Leu Asn Thr Asp Glu Asn Lys Lys Lys Val
    130                 135                 140                 
Lys Asp Ala Leu Glu Trp Leu His Lys Asn Ala Tyr Gly Lys Glu Pro
145                 150                 155                 160 
Asp Lys Lys Val Lys Glu Leu Ser Glu Asn Phe Thr Lys Thr Thr Gly
                165                 170                 175     
Lys Asn Thr Asn Leu Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro Lys
            180                 185                 190         
Ser Leu Thr Asn Thr Leu Ile Leu Leu Asn Asp Gln Phe Ser Asn Glu
        195                 200                 205             
Glu Lys Lys Lys Phe Thr Ala Pro Ile Lys Thr Phe Ala Pro Asp Ser
    210                 215                 220                 
Asp Lys Ile Leu Ser Ser Val Gly Lys Ala Glu Leu Ala Lys Gly Gly
225                 230                 235                 240 
Asn Leu Val Asp Ile Ser Lys Val Lys Leu Leu Glu Cys Ile Ile Glu
                245                 250                 255     
Glu Asp Lys Asp Met Met Lys Lys Ser Ile Asp Ser Phe Asn Lys Val
            260                 265                 270         
Phe Thr Tyr Val Gln Asp Ser Ala Thr Gly Lys Glu Arg Asn Gly Phe
        275                 280                 285             
Tyr Lys Asp Gly Ser Tyr Ile Asp His Gln Asp Val Pro Tyr Thr Gly
    290                 295                 300                 
Ala Tyr Gly Val Val Leu Leu Glu Gly Ile Ser Gln Met Met Pro Met
305                 310                 315                 320 
Ile Lys Glu Thr Pro Phe Asn Asp Lys Thr Gln Asn Asp Thr Thr Leu
                325                 330                 335     
Lys Ser Trp Ile Asp Asp Gly Phe Met Pro Leu Ile Tyr Lys Gly Glu
            340                 345                 350         
Met Met Asp Leu Ser Arg Gly Arg Ala Ile Ser Arg Glu Asn Glu Thr
        355                 360                 365             
Ser His Ser Ala Ser Ala Thr Val Met Lys Ser Leu Leu Arg Leu Ser
    370                 375                 380                 
Asp Ala Met Asp Asp Ser Thr Lys Ala Lys Tyr Lys Lys Ile Val Lys
385                 390                 395                 400 
Ser Ser Val Glu Ser Asp Ser Ser Tyr Lys Gln Asn Asp Tyr Leu Asn
                405                 410                 415     
Ser Tyr Ser Asp Ile Asp Lys Met Lys Ser Leu Met Thr Asp Asn Ser
            420                 425                 430         
Ile Ser Lys Asn Gly Leu Thr Gln Gln Leu Lys Ile Tyr Asn Asp Met
        435                 440                 445             
Asp Arg Val Thr Tyr His Asn Lys Asp Leu Asp Phe Ala Phe Gly Leu
    450                 455                 460                 
Ser Met Thr Ser Lys Asn Val Ala Arg Tyr Glu Ser Ile Asn Gly Glu
465                 470                 475                 480 
Asn Leu Lys Gly Trp His Thr Gly Ala Gly Met Ser Tyr Leu Tyr Asn
                485                 490                 495     
Ser Asp Val Lys His Tyr His Asp Asn Phe Trp Val Thr Ala Asp Met
            500                 505                 510         
Lys Arg Leu Ser Gly Thr Thr Thr Leu Asp Asn Glu Ile Leu Lys Asp
        515                 520                 525             
Thr Asp Asp Lys Lys Ser Ser Lys Thr Phe Val Gly Gly Thr Lys Val
    530                 535                 540                 
Asp Asp Gln His Ala Ser Ile Gly Met Asp Phe Glu Asn Gln Asp Lys
545                 550                 555                 560 
Thr Leu Thr Ala Lys Lys Ser Tyr Phe Ile Leu Asn Asp Lys Ile Val
                565                 570                 575     
Phe Leu Gly Thr Gly Ile Lys Ser Thr Asp Ser Ser Lys Asn Pro Val
            580                 585                 590         
Thr Thr Ile Glu Asn Arg Lys Ala Asn Gly Tyr Thr Leu Tyr Thr Asp
        595                 600                 605             
Asp Lys Gln Thr Thr Asn Ser Asp Asn Gln Glu Asn Asn Ser Val Phe
    610                 615                 620                 
Leu Glu Ser Thr Asp Thr Lys Lys Asn Ile Gly Tyr His Phe Leu Asn
625                 630                 635                 640 
Lys Pro Lys Ile Thr Val Lys Lys Glu Ser His Thr Gly Lys Trp Lys
                645                 650                 655     
Glu Ile Asn Lys Ser Gln Lys Asp Thr Gln Lys Thr Asp Glu Tyr Tyr
            660                 665                 670         
Glu Val Thr Gln Lys His Ser Asn Ser Asp Asn Lys Tyr Gly Tyr Val
        675                 680                 685             
Leu Tyr Pro Gly Leu Ser Lys Asp Val Phe Lys Thr Lys Lys Asp Glu
    690                 695                 700                 
Val Thr Val Val Lys Gln Glu Asp Asp Phe His Val Val Lys Asp Asn
705                 710                 715                 720 
Glu Ser Val Trp Ala Gly Val Asn Tyr Ser Asn Ser Thr Gln Thr Phe
                725                 730                 735     
Asp Ile Asn Asn Thr Lys Val Glu Val Lys Ala Lys Gly Met Phe Ile
            740                 745                 750         
Leu Lys Lys Lys Asp Asp Asn Thr Tyr Glu Cys Ser Phe Tyr Asn Pro
        755                 760                 765             
Glu Ser Thr Asn Ser Ala Ser Asp Ile Glu Ser Lys Ile Ser Met Thr
    770                 775                 780                 
Gly Tyr Ser Ile Thr Asn Lys Asn Thr Ser Thr Ser Asn Glu Ser Gly
785                 790                 795                 800 
Val His Phe Glu Leu Thr Lys
                805         


<210> 290
<211> 1066
<212> PRT
<213> Streptococcus pneumoniae

<220> 
<223> hyaluronan lyase

<400> 290
Met Gln Thr Lys Thr Lys Lys Leu Ile Val Ser Leu Ser Ser Leu Val
 1               5                  10                  15      
Leu Ser Gly Phe Leu Leu Asn His Tyr Met Thr Ile Gly Ala Glu Glu
            20                  25                  30          
Thr Thr Thr Asn Thr Ile Gln Gln Ser Gln Lys Glu Val Gln Tyr Gln
        35                  40                  45              
Gln Arg Asp Thr Lys Asn Leu Val Glu Asn Gly Asp Phe Gly Gln Thr
    50                  55                  60                  
Glu Asp Gly Ser Ser Pro Trp Thr Gly Ser Lys Ala Gln Gly Trp Ser
65                  70                  75                  80  
Ala Trp Val Asp Gln Lys Asn Ser Ala Asp Ala Ser Thr Arg Val Ile
                85                  90                  95      
Glu Ala Lys Asp Gly Ala Ile Thr Ile Ser Ser His Glu Lys Leu Arg
            100                 105                 110         
Ala Ala Leu His Arg Met Val Pro Ile Glu Ala Lys Lys Lys Tyr Lys
        115                 120                 125             
Leu Arg Phe Lys Ile Lys Thr Asp Asn Lys Ile Gly Ile Ala Lys Val
    130                 135                 140                 
Arg Ile Ile Glu Glu Ser Gly Lys Asp Lys Arg Leu Trp Asn Ser Ala
145                 150                 155                 160 
Thr Thr Ser Gly Thr Lys Asp Trp Gln Thr Ile Glu Ala Asp Tyr Ser
                165                 170                 175     
Pro Thr Leu Asp Val Asp Lys Ile Lys Leu Glu Leu Phe Tyr Glu Thr
            180                 185                 190         
Gly Thr Gly Thr Val Ser Phe Lys Asp Ile Glu Leu Val Glu Val Ala
        195                 200                 205             
Asp Gln Leu Ser Glu Asp Ser Gln Thr Asp Lys Gln Leu Glu Glu Lys
    210                 215                 220                 
Ile Asp Leu Pro Ile Gly Lys Lys His Val Phe Ser Leu Ala Asp Tyr
225                 230                 235                 240 
Thr Tyr Lys Val Glu Asn Pro Asp Val Ala Ser Val Lys Asn Gly Ile
                245                 250                 255     
Leu Glu Pro Leu Lys Glu Gly Thr Thr Asn Val Ile Val Ser Lys Asp
            260                 265                 270         
Gly Lys Glu Val Lys Lys Ile Pro Leu Lys Ile Leu Ala Ser Val Lys
        275                 280                 285             
Asp Ala Tyr Thr Asp Arg Leu Asp Asp Trp Asn Gly Ile Ile Ala Gly
    290                 295                 300                 
Asn Gln Tyr Tyr Asp Ser Lys Asn Glu Gln Met Ala Lys Leu Asn Gln
305                 310                 315                 320 
Glu Leu Glu Gly Lys Val Ala Asp Ser Leu Ser Ser Ile Ser Ser Gln
                325                 330                 335     
Ala Asp Arg Thr Tyr Leu Trp Glu Lys Phe Ser Asn Tyr Lys Thr Ser
            340                 345                 350         
Ala Asn Leu Thr Ala Thr Tyr Arg Lys Leu Glu Glu Met Ala Lys Gln
        355                 360                 365             
Val Thr Asn Pro Ser Ser Arg Tyr Tyr Gln Asp Glu Thr Val Val Arg
    370                 375                 380                 
Thr Val Arg Asp Ser Met Glu Trp Met His Lys His Val Tyr Asn Ser
385                 390                 395                 400 
Glu Lys Ser Ile Val Gly Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro
                405                 410                 415     
Arg Ala Ile Asn Asn Thr Leu Ser Leu Met Lys Glu Tyr Phe Ser Asp
            420                 425                 430         
Glu Glu Ile Lys Lys Tyr Thr Asp Val Ile Glu Lys Phe Val Pro Asp
        435                 440                 445             
Pro Glu His Phe Arg Lys Thr Thr Asp Asn Pro Phe Lys Ala Leu Gly
    450                 455                 460                 
Gly Asn Leu Val Asp Met Gly Arg Val Lys Val Ile Ala Gly Leu Leu
465                 470                 475                 480 
Arg Lys Asp Asp Gln Glu Ile Ser Ser Thr Ile Arg Ser Ile Glu Gln
                485                 490                 495     
Val Phe Lys Leu Val Asp Gln Gly Glu Gly Phe Tyr Gln Asp Gly Ser
            500                 505                 510         
Tyr Ile Asp His Thr Asn Val Ala Tyr Thr Gly Ala Tyr Gly Asn Val
        515                 520                 525             
Leu Ile Asp Gly Leu Ser Gln Leu Leu Pro Val Ile Gln Lys Thr Lys
    530                 535                 540                 
Asn Pro Ile Asp Lys Asp Lys Met Gln Thr Met Tyr His Trp Ile Asp
545                 550                 555                 560 
Lys Ser Phe Ala Pro Leu Leu Val Asn Gly Glu Leu Met Asp Met Ser
                565                 570                 575     
Arg Gly Arg Ser Ile Ser Arg Ala Asn Ser Glu Gly His Val Ala Ala
            580                 585                 590         
Val Glu Val Leu Arg Gly Ile His Arg Ile Ala Asp Met Ser Glu Gly
        595                 600                 605             
Glu Thr Lys Gln Cys Leu Gln Ser Leu Val Lys Thr Ile Val Gln Ser
    610                 615                 620                 
Asp Ser Tyr Tyr Asp Val Phe Lys Asn Leu Lys Thr Tyr Lys Asp Ile
625                 630                 635                 640 
Ser Leu Met Gln Ser Leu Leu Ser Asp Ala Gly Val Ala Ser Val Pro
                645                 650                 655     
Arg Pro Ser Tyr Leu Ser Ala Phe Asn Lys Met Asp Lys Thr Ala Met
            660                 665                 670         
Tyr Asn Ala Glu Lys Gly Phe Gly Phe Gly Leu Ser Leu Phe Ser Ser
        675                 680                 685             
Arg Thr Leu Asn Tyr Glu His Met Asn Lys Glu Asn Lys Arg Gly Trp
    690                 695                 700                 
Tyr Thr Ser Asp Gly Met Phe Tyr Leu Tyr Asn Gly Asp Leu Ser His
705                 710                 715                 720 
Tyr Ser Asp Gly Tyr Trp Pro Thr Val Asn Pro Tyr Lys Met Pro Gly
                725                 730                 735     
Thr Thr Glu Thr Asp Ala Lys Arg Ala Asp Ser Asp Thr Gly Lys Val
            740                 745                 750         
Leu Pro Ser Ala Phe Val Gly Thr Ser Lys Leu Asp Asp Ala Asn Ala
        755                 760                 765             
Thr Ala Thr Met Asp Phe Thr Asn Trp Asn Gln Thr Leu Thr Ala His
    770                 775                 780                 
Lys Ser Trp Phe Met Leu Lys Asp Lys Ile Ala Phe Leu Gly Ser Asn
785                 790                 795                 800 
Ile Gln Asn Thr Ser Thr Asp Thr Ala Ala Thr Thr Ile Asp Gln Arg
                805                 810                 815     
Lys Leu Glu Ser Gly Asn Pro Tyr Lys Val Tyr Val Asn Asp Lys Glu
            820                 825                 830         
Ala Ser Leu Thr Glu Gln Glu Lys Asp Tyr Pro Glu Thr Gln Ser Val
        835                 840                 845             
Phe Leu Glu Ser Phe Asp Ser Lys Lys Asn Ile Gly Tyr Phe Phe Phe
    850                 855                 860                 
Lys Lys Ser Ser Ile Ser Met Ser Lys Ala Leu Gln Lys Gly Ala Trp
865                 870                 875                 880 
Lys Asp Ile Asn Glu Gly Gln Ser Asp Lys Glu Val Glu Asn Glu Phe
                885                 890                 895     
Leu Thr Ile Ser Gln Ala His Lys Gln Asn Arg Asp Ser Tyr Gly Tyr
            900                 905                 910         
Met Leu Ile Pro Asn Val Asp Arg Ala Thr Phe Asn Gln Met Ile Lys
        915                 920                 925             
Glu Leu Glu Ser Ser Leu Ile Glu Asn Asn Glu Thr Leu Gln Ser Val
    930                 935                 940                 
Tyr Asp Ala Lys Gln Gly Val Trp Gly Ile Val Lys Tyr Asp Asp Ser
945                 950                 955                 960 
Val Ser Thr Ile Ser Asn Gln Phe Gln Val Leu Lys Arg Gly Val Tyr
                965                 970                 975     
Thr Ile Arg Lys Glu Gly Asp Glu Tyr Lys Ile Ala Tyr Tyr Asn Pro
            980                 985                 990         
Glu Thr Gln Glu Ser Ala Pro Asp Gln Glu Val Phe Lys Lys Leu Glu
        995                 1000                1005            
Gln Ala Ala Gln Pro Gln Val Gln Asn Ser Lys Glu Lys Glu Lys Ser
    1010                1015                1020                
Glu Glu Glu Lys Asn His Ser Asp Gln Lys Asn Leu Pro Gln Thr Gly
1025                1030                1035               1040 
Glu Gly Gln Ser Ile Leu Ala Ser Leu Gly Phe Leu Leu Leu Gly Ala
                1045                1050                1055    
Phe Tyr Leu Phe Arg Arg Gly Lys Asn Asn
            1060                1065    


<210> 291
<211> 1078
<212> PRT
<213> Streptococcus pneumoniae (strain ATCC BAA-255/R6)

<220> 
<223> hyaluronan lyase

<400> 291
Met Ile Leu Gln Tyr Val Tyr Trp Ser Val Tyr Met Gln Thr Lys Thr
 1               5                  10                  15      
Lys Lys Leu Ile Val Ser Leu Ser Ser Leu Val Leu Ser Gly Phe Leu
            20                  25                  30          
Leu Asn His Tyr Met Thr Val Gly Ala Glu Glu Thr Thr Thr Asn Thr
        35                  40                  45              
Ile Gln Gln Ser Gln Lys Glu Val Gln Tyr Gln Gln Arg Asp Thr Lys
    50                  55                  60                  
Asn Leu Val Glu Asn Gly Asp Phe Gly Gln Thr Glu Asp Gly Ser Ser
65                  70                  75                  80  
Pro Trp Thr Gly Ser Lys Ala Gln Gly Trp Ser Ala Trp Val Asp Gln
                85                  90                  95      
Lys Asn Ser Ser Ala Asp Ala Ser Thr Arg Val Ile Glu Ala Lys Asp
            100                 105                 110         
Gly Ala Ile Thr Ile Ser Ser Pro Glu Lys Leu Arg Ala Ala Val His
        115                 120                 125             
Arg Met Val Pro Ile Glu Ala Lys Lys Lys Tyr Lys Leu Arg Phe Lys
    130                 135                 140                 
Ile Lys Thr Asp Asn Lys Val Gly Ile Ala Lys Val Arg Ile Ile Glu
145                 150                 155                 160 
Glu Ser Gly Lys Asp Lys Arg Leu Trp Asn Ser Ala Thr Thr Ser Gly
                165                 170                 175     
Thr Lys Asp Trp Gln Thr Ile Glu Ala Asp Tyr Ser Pro Thr Leu Asp
            180                 185                 190         
Val Asp Lys Ile Lys Leu Glu Leu Phe Tyr Glu Thr Gly Thr Gly Thr
        195                 200                 205             
Val Ser Phe Lys Asp Ile Glu Leu Val Glu Val Ala Asp Gln Pro Ser
    210                 215                 220                 
Glu Asp Ser Gln Thr Asp Lys Gln Leu Glu Glu Lys Ile Asp Leu Pro
225                 230                 235                 240 
Ile Gly Lys Lys His Val Phe Ser Leu Ala Asp Tyr Thr Tyr Lys Val
                245                 250                 255     
Glu Asn Pro Asp Val Ala Ser Val Lys Asn Gly Ile Leu Glu Pro Leu
            260                 265                 270         
Lys Glu Gly Thr Thr Asn Val Ile Val Ser Lys Asp Gly Lys Glu Val
        275                 280                 285             
Lys Lys Ile Pro Leu Lys Ile Leu Ala Ser Val Lys Asp Thr Tyr Thr
    290                 295                 300                 
Asp Arg Leu Asp Asp Trp Asn Gly Ile Ile Ala Gly Asn Gln Tyr Tyr
305                 310                 315                 320 
Asp Ser Lys Asn Glu Gln Met Ala Lys Leu Asn Gln Glu Leu Glu Gly
                325                 330                 335     
Lys Val Ala Asp Ser Leu Ser Ser Ile Ser Ser Gln Ala Asp Arg Ile
            340                 345                 350         
Tyr Leu Trp Glu Lys Phe Ser Asn Tyr Lys Thr Ser Ala Asn Leu Thr
        355                 360                 365             
Ala Thr Tyr Arg Lys Leu Glu Glu Met Ala Lys Gln Val Thr Asn Pro
    370                 375                 380                 
Ser Ser Arg Tyr Tyr Gln Asp Glu Thr Val Val Arg Thr Val Arg Asp
385                 390                 395                 400 
Ser Met Glu Trp Met His Lys His Val Tyr Asn Ser Glu Lys Ser Ile
                405                 410                 415     
Val Gly Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro Arg Ala Ile Asn
            420                 425                 430         
Asn Thr Leu Ser Leu Met Lys Glu Tyr Phe Ser Asp Glu Glu Ile Lys
        435                 440                 445             
Lys Tyr Thr Asp Val Ile Glu Lys Phe Val Pro Asp Pro Glu His Phe
    450                 455                 460                 
Arg Lys Thr Thr Asp Asn Pro Phe Lys Ala Leu Gly Gly Asn Leu Val
465                 470                 475                 480 
Asp Met Gly Arg Val Lys Val Ile Ala Gly Leu Leu Arg Lys Asp Asp
                485                 490                 495     
Gln Glu Ile Ser Ser Thr Ile Arg Ser Ile Glu Gln Val Phe Lys Leu
            500                 505                 510         
Val Asp Gln Gly Glu Gly Phe Tyr Gln Asp Gly Ser Tyr Ile Asp His
        515                 520                 525             
Thr Asn Val Ala Tyr Thr Gly Ala Tyr Gly Asn Val Leu Ile Asp Gly
    530                 535                 540                 
Leu Ser Gln Leu Leu Pro Val Ile Gln Lys Thr Lys Asn Pro Ile Asp
545                 550                 555                 560 
Lys Asp Lys Met Gln Thr Met Tyr His Trp Ile Asp Lys Ser Phe Ala
                565                 570                 575     
Pro Leu Leu Val Asn Gly Glu Leu Met Asp Met Ser Arg Gly Arg Ser
            580                 585                 590         
Ile Ser Arg Ala Asn Ser Glu Gly His Val Ala Ala Val Glu Val Leu
        595                 600                 605             
Arg Gly Ile His Arg Ile Ala Asp Met Ser Glu Gly Glu Thr Lys Gln
    610                 615                 620                 
Arg Leu Gln Ser Leu Val Lys Thr Ile Val Gln Ser Asp Ser Tyr Tyr
625                 630                 635                 640 
Asp Val Phe Lys Asn Leu Lys Thr Tyr Lys Asp Ile Ser Leu Met Gln
                645                 650                 655     
Ser Leu Leu Ser Asp Ala Gly Val Ala Ser Val Pro Arg Thr Ser Tyr
            660                 665                 670         
Leu Ser Ala Phe Asn Lys Met Asp Lys Thr Ala Met Tyr Asn Ala Glu
        675                 680                 685             
Lys Gly Phe Gly Phe Gly Leu Ser Leu Phe Ser Ser Arg Thr Leu Asn
    690                 695                 700                 
Tyr Glu His Met Asn Lys Glu Asn Lys Arg Gly Trp Tyr Thr Ser Asp
705                 710                 715                 720 
Gly Met Phe Tyr Leu Tyr Asn Gly Asp Leu Ser His Tyr Ser Asp Gly
                725                 730                 735     
Tyr Trp Pro Thr Val Asn Pro Tyr Lys Met Pro Gly Thr Thr Glu Thr
            740                 745                 750         
Asp Ala Lys Arg Ala Asp Ser Asp Thr Gly Lys Val Leu Pro Ser Ala
        755                 760                 765             
Phe Val Gly Thr Ser Lys Leu Asp Asp Ala Asn Ala Thr Ala Thr Met
    770                 775                 780                 
Asp Phe Thr Asn Trp Asn Gln Thr Leu Thr Ala His Lys Ser Trp Phe
785                 790                 795                 800 
Met Leu Lys Asp Lys Ile Ala Phe Leu Gly Ser Asn Ile Gln Asn Thr
                805                 810                 815     
Ser Thr Asp Thr Ala Ala Thr Thr Ile Asp Gln Arg Lys Leu Glu Ser
            820                 825                 830         
Ser Asn Pro Tyr Lys Val Tyr Val Asn Asp Lys Glu Ala Ser Leu Thr
        835                 840                 845             
Glu Gln Glu Lys Asp Tyr Pro Glu Thr Gln Ser Val Phe Leu Glu Ser
    850                 855                 860                 
Ser Asp Ser Lys Lys Asn Ile Gly Tyr Phe Phe Phe Lys Lys Ser Ser
865                 870                 875                 880 
Ile Ser Met Ser Lys Ala Leu Gln Lys Gly Ala Trp Lys Asp Ile Asn
                885                 890                 895     
Glu Gly Gln Ser Asp Lys Glu Val Glu Asn Glu Phe Leu Thr Ile Ser
            900                 905                 910         
Gln Ala His Lys Gln Asn Gly Asp Ser Tyr Gly Tyr Met Leu Ile Pro
        915                 920                 925             
Asn Val Asp Arg Ala Thr Phe Asn Gln Met Ile Lys Glu Leu Glu Ser
    930                 935                 940                 
Ser Leu Ile Glu Asn Asn Glu Thr Leu Gln Ser Val Tyr Asp Ala Lys
945                 950                 955                 960 
Gln Gly Val Trp Gly Ile Val Lys Tyr Asp Asp Ser Val Ser Thr Ile
                965                 970                 975     
Ser Asn Gln Phe Gln Val Leu Lys Arg Gly Val Tyr Thr Ile Arg Lys
            980                 985                 990         
Glu Gly Asp Glu Tyr Lys Ile Ala Tyr Tyr Asn Pro Glu Thr Gln Glu
        995                 1000                1005            
Ser Ala Pro Asp Gln Glu Val Phe Lys Lys Leu Glu Gln Ala Ala Gln
    1010                1015                1020                
Pro Gln Val Gln Asn Ser Lys Glu Lys Glu Lys Ser Glu Glu Glu Lys
1025                1030                1035               1040 
Asn His Ser Asp Gln Lys Asn Leu Pro Gln Thr Gly Glu Gly Gln Ser
                1045                1050                1055    
Ile Leu Ala Ser Leu Gly Phe Leu Leu Leu Gly Ala Phe Tyr Leu Phe
            1060                1065                1070        
Arg Arg Gly Lys Asn Asn
        1075            


<210> 292
<211> 1067
<212> PRT
<213> Streptococcus pneumoniae serotype 2 (strain D39/NCTC 7466)

<220> 
<223> hyaluronan lyase

<400> 292
Met Gln Thr Lys Thr Lys Lys Leu Ile Val Ser Leu Ser Ser Leu Val
 1               5                  10                  15      
Leu Ser Gly Phe Leu Leu Asn His Tyr Met Thr Val Gly Ala Glu Glu
            20                  25                  30          
Thr Thr Thr Asn Thr Ile Gln Gln Ser Gln Lys Glu Val Gln Tyr Gln
        35                  40                  45              
Gln Arg Asp Thr Lys Asn Leu Val Glu Asn Gly Asp Phe Gly Gln Thr
    50                  55                  60                  
Glu Asp Gly Ser Ser Pro Trp Thr Gly Ser Lys Ala Gln Gly Trp Ser
65                  70                  75                  80  
Ala Trp Val Asp Gln Lys Asn Ser Ser Ala Asp Ala Ser Thr Arg Val
                85                  90                  95      
Ile Glu Ala Lys Asp Gly Ala Ile Thr Ile Ser Ser Pro Glu Lys Leu
            100                 105                 110         
Arg Ala Ala Val His Arg Met Val Pro Ile Glu Ala Lys Lys Lys Tyr
        115                 120                 125             
Lys Leu Arg Phe Lys Ile Lys Thr Asp Asn Lys Val Gly Ile Ala Lys
    130                 135                 140                 
Val Arg Ile Ile Glu Glu Ser Gly Lys Asp Lys Arg Leu Trp Asn Ser
145                 150                 155                 160 
Ala Thr Thr Ser Gly Thr Lys Asp Trp Gln Thr Ile Glu Ala Asp Tyr
                165                 170                 175     
Ser Pro Thr Leu Asp Val Asp Lys Ile Lys Leu Glu Leu Phe Tyr Glu
            180                 185                 190         
Thr Gly Thr Gly Thr Val Ser Phe Lys Asp Ile Glu Leu Val Glu Val
        195                 200                 205             
Ala Asp Gln Pro Ser Glu Asp Ser Gln Thr Asp Lys Gln Leu Glu Glu
    210                 215                 220                 
Lys Ile Asp Leu Pro Ile Gly Lys Lys His Val Phe Ser Leu Ala Asp
225                 230                 235                 240 
Tyr Thr Tyr Lys Val Glu Asn Pro Asp Val Ala Ser Val Lys Asn Gly
                245                 250                 255     
Ile Leu Glu Pro Leu Lys Glu Gly Thr Thr Asn Val Ile Val Ser Lys
            260                 265                 270         
Asp Gly Lys Glu Val Lys Lys Ile Pro Leu Lys Ile Leu Ala Ser Val
        275                 280                 285             
Lys Asp Thr Tyr Thr Asp Arg Leu Asp Asp Trp Asn Gly Ile Ile Ala
    290                 295                 300                 
Gly Asn Gln Tyr Tyr Asp Ser Lys Asn Glu Gln Met Ala Lys Leu Asn
305                 310                 315                 320 
Gln Glu Leu Glu Gly Lys Val Ala Asp Ser Leu Ser Ser Ile Ser Ser
                325                 330                 335     
Gln Ala Asp Arg Ile Tyr Leu Trp Glu Lys Phe Ser Asn Tyr Lys Thr
            340                 345                 350         
Ser Ala Asn Leu Thr Ala Thr Tyr Arg Lys Leu Glu Glu Met Ala Lys
        355                 360                 365             
Gln Val Thr Asn Pro Ser Ser Arg Tyr Tyr Gln Asp Glu Thr Val Val
    370                 375                 380                 
Arg Thr Val Arg Asp Ser Met Glu Trp Met His Lys His Val Tyr Asn
385                 390                 395                 400 
Ser Glu Lys Ser Ile Val Gly Asn Trp Trp Asp Tyr Glu Ile Gly Thr
                405                 410                 415     
Pro Arg Ala Ile Asn Asn Thr Leu Ser Leu Met Lys Glu Tyr Phe Ser
            420                 425                 430         
Asp Glu Glu Ile Lys Lys Tyr Thr Asp Val Ile Glu Lys Phe Val Pro
        435                 440                 445             
Asp Pro Glu His Phe Arg Lys Thr Thr Asp Asn Pro Phe Lys Ala Leu
    450                 455                 460                 
Gly Gly Asn Leu Val Asp Met Gly Arg Val Lys Val Ile Ala Gly Leu
465                 470                 475                 480 
Leu Arg Lys Asp Asp Gln Glu Ile Ser Ser Thr Ile Arg Ser Ile Glu
                485                 490                 495     
Gln Val Phe Lys Leu Val Asp Gln Gly Glu Gly Phe Tyr Gln Asp Gly
            500                 505                 510         
Ser Tyr Ile Asp His Thr Asn Val Ala Tyr Thr Gly Ala Tyr Gly Asn
        515                 520                 525             
Val Leu Ile Asp Gly Leu Ser Gln Leu Leu Pro Val Ile Gln Lys Thr
    530                 535                 540                 
Lys Asn Pro Ile Asp Lys Asp Lys Met Gln Thr Met Tyr His Trp Ile
545                 550                 555                 560 
Asp Lys Ser Phe Ala Pro Leu Leu Val Asn Gly Glu Leu Met Asp Met
                565                 570                 575     
Ser Arg Gly Arg Ser Ile Ser Arg Ala Asn Ser Glu Gly His Val Ala
            580                 585                 590         
Ala Val Glu Val Leu Arg Gly Ile His Arg Ile Ala Asp Met Ser Glu
        595                 600                 605             
Gly Glu Thr Lys Gln Arg Leu Gln Ser Leu Val Lys Thr Ile Val Gln
    610                 615                 620                 
Ser Asp Ser Tyr Tyr Asp Val Phe Lys Asn Leu Lys Thr Tyr Lys Asp
625                 630                 635                 640 
Ile Ser Leu Met Gln Ser Leu Leu Ser Asp Ala Gly Val Ala Ser Val
                645                 650                 655     
Pro Arg Thr Ser Tyr Leu Ser Ala Phe Asn Lys Met Asp Lys Thr Ala
            660                 665                 670         
Met Tyr Asn Ala Glu Lys Gly Phe Gly Phe Gly Leu Ser Leu Phe Ser
        675                 680                 685             
Ser Arg Thr Leu Asn Tyr Glu His Met Asn Lys Glu Asn Lys Arg Gly
    690                 695                 700                 
Trp Tyr Thr Ser Asp Gly Met Phe Tyr Leu Tyr Asn Gly Asp Leu Ser
705                 710                 715                 720 
His Tyr Ser Asp Gly Tyr Trp Pro Thr Val Asn Pro Tyr Lys Met Pro
                725                 730                 735     
Gly Thr Thr Glu Thr Asp Ala Lys Arg Ala Asp Ser Asp Thr Gly Lys
            740                 745                 750         
Val Leu Pro Ser Ala Phe Val Gly Thr Ser Lys Leu Asp Asp Ala Asn
        755                 760                 765             
Ala Thr Ala Thr Met Asp Phe Thr Asn Trp Asn Gln Thr Leu Thr Ala
    770                 775                 780                 
His Lys Ser Trp Phe Met Leu Lys Asp Lys Ile Ala Phe Leu Gly Ser
785                 790                 795                 800 
Asn Ile Gln Asn Thr Ser Thr Asp Thr Ala Ala Thr Thr Ile Asp Gln
                805                 810                 815     
Arg Lys Leu Glu Ser Ser Asn Pro Tyr Lys Val Tyr Val Asn Asp Lys
            820                 825                 830         
Glu Ala Ser Leu Thr Glu Gln Glu Lys Asp Tyr Pro Glu Thr Gln Ser
        835                 840                 845             
Val Phe Leu Glu Ser Ser Asp Ser Lys Lys Asn Ile Gly Tyr Phe Phe
    850                 855                 860                 
Phe Lys Lys Ser Ser Ile Ser Met Ser Lys Ala Leu Gln Lys Gly Ala
865                 870                 875                 880 
Trp Lys Asp Ile Asn Glu Gly Gln Ser Asp Lys Glu Val Glu Asn Glu
                885                 890                 895     
Phe Leu Thr Ile Ser Gln Ala His Lys Gln Asn Gly Asp Ser Tyr Gly
            900                 905                 910         
Tyr Met Leu Ile Pro Asn Val Asp Arg Ala Thr Phe Asn Gln Met Ile
        915                 920                 925             
Lys Glu Leu Glu Ser Ser Leu Ile Glu Asn Asn Glu Thr Leu Gln Ser
    930                 935                 940                 
Val Tyr Asp Ala Lys Gln Gly Val Trp Gly Ile Val Lys Tyr Asp Asp
945                 950                 955                 960 
Ser Val Ser Thr Ile Ser Asn Gln Phe Gln Val Leu Lys Arg Gly Val
                965                 970                 975     
Tyr Thr Ile Arg Lys Glu Gly Asp Glu Tyr Lys Ile Ala Tyr Tyr Asn
            980                 985                 990         
Pro Glu Thr Gln Glu Ser Ala Pro Asp Gln Glu Val Phe Lys Lys Leu
        995                 1000                1005            
Glu Gln Ala Ala Gln Pro Gln Val Gln Asn Ser Lys Glu Lys Glu Lys
    1010                1015                1020                
Ser Glu Glu Glu Lys Asn His Ser Asp Gln Lys Asn Leu Pro Gln Thr
1025                1030                1035               1040 
Gly Glu Gly Gln Ser Ile Leu Ala Ser Leu Gly Phe Leu Leu Leu Gly
                1045                1050                1055    
Ala Phe Tyr Leu Phe Arg Arg Gly Lys Asn Asn
            1060                1065        


<210> 293
<211> 805
<212> PRT
<213> Streptococcus pyogenes serotype M1

<220> 
<223> hyaluronan lyase

<400> 293
Met Asn Thr Tyr Phe Cys Thr His His Lys Gln Leu Leu Leu Tyr Ser
 1               5                  10                  15      
Asn Leu Phe Leu Ser Phe Ala Met Met Gly Gln Gly Thr Ala Ile Tyr
            20                  25                  30          
Ala Asp Thr Leu Thr Ser Asn Ser Glu Pro Asn Asn Thr Tyr Phe Gln
        35                  40                  45              
Thr Gln Thr Leu Thr Thr Thr Asp Ser Glu Lys Lys Val Val Gln Pro
    50                  55                  60                  
Gln Gln Lys Asp Tyr Tyr Thr Glu Leu Leu Asp Gln Trp Asn Ser Ile
65                  70                  75                  80  
Ile Ala Gly Asn Asp Ala Tyr Asp Lys Thr Asn Pro Asp Met Val Thr
                85                  90                  95      
Phe His Asn Lys Ala Glu Lys Asp Ala Gln Asn Ile Ile Lys Ser Tyr
            100                 105                 110         
Gln Gly Pro Asp His Glu Asn Arg Thr Tyr Leu Trp Glu His Ala Lys
        115                 120                 125             
Asp Tyr Ser Ala Ser Ala Asn Ile Thr Lys Thr Tyr Arg Asn Ile Glu
    130                 135                 140                 
Lys Ile Ala Lys Gln Ile Thr Asn Pro Glu Ser Cys Tyr Tyr Gln Asp
145                 150                 155                 160 
Ser Lys Ala Ile Ala Ile Val Lys Asp Gly Met Ala Phe Met Tyr Glu
                165                 170                 175     
His Ala Tyr Asn Leu Asp Arg Glu Asn His Gln Thr Thr Gly Lys Glu
            180                 185                 190         
Asn Lys Glu Asn Trp Trp Val Tyr Glu Ile Gly Thr Pro Arg Ala Ile
        195                 200                 205             
Asn Asn Thr Leu Ser Leu Met Tyr Pro Tyr Phe Thr Gln Glu Glu Ile
    210                 215                 220                 
Leu Lys Tyr Thr Ala Pro Ile Glu Lys Phe Val Pro Asp Pro Thr Arg
225                 230                 235                 240 
Phe Arg Val Arg Ala Ala Asn Phe Ser Pro Phe Glu Ala Asn Ser Gly
                245                 250                 255     
Asn Leu Ile Asp Met Gly Arg Val Lys Leu Ile Ser Gly Ile Leu Arg
            260                 265                 270         
Lys Asp Asp Leu Glu Ile Ser Asp Thr Ile Lys Ala Ile Glu Lys Val
        275                 280                 285             
Phe Thr Leu Val Asp Glu Gly Asn Gly Phe Tyr Gln Asp Gly Ser Leu
    290                 295                 300                 
Ile Asp His Val Val Thr Asn Ala Gln Ser Pro Leu Tyr Lys Lys Gly
305                 310                 315                 320 
Ile Ala Tyr Thr Gly Ala Tyr Gly Asn Val Leu Ile Asp Gly Leu Ser
                325                 330                 335     
Gln Leu Ile Pro Ile Ile Gln Lys Thr Lys Ser Pro Ile Lys Ala Asp
            340                 345                 350         
Lys Met Ala Thr Ile Tyr His Trp Ile Asn His Ser Phe Phe Pro Ile
        355                 360                 365             
Ile Val Arg Gly Glu Met Met Asp Met Thr Arg Gly Arg Ser Ile Ser
    370                 375                 380                 
Arg Phe Asn Ala Gln Ser His Val Ala Gly Ile Glu Ala Leu Arg Ala
385                 390                 395                 400 
Ile Leu Arg Ile Ala Asp Met Ser Glu Glu Pro His Arg Leu Ala Leu
                405                 410                 415     
Lys Thr Arg Ile Lys Thr Leu Val Thr Gln Gly Asn Ala Phe Tyr Asn
            420                 425                 430         
Val Tyr Asp Asn Leu Lys Thr Tyr His Asp Ile Lys Leu Met Lys Glu
        435                 440                 445             
Leu Leu Ser Asp Thr Ser Val Pro Val Gln Lys Leu Asp Ser Tyr Val
    450                 455                 460                 
Ala Ser Phe Asn Ser Met Asp Lys Leu Ala Leu Tyr Asn Asn Lys His
465                 470                 475                 480 
Asp Phe Ala Phe Gly Leu Ser Met Phe Ser Asn Arg Thr Gln Asn Tyr
                485                 490                 495     
Glu Ala Met Asn Asn Glu Asn Leu His Gly Trp Phe Thr Ser Asp Gly
            500                 505                 510         
Met Phe Tyr Leu Tyr Asn Asn Asp Leu Gly His Tyr Ser Glu Asn Tyr
        515                 520                 525             
Trp Ala Thr Val Asn Pro Tyr Arg Leu Pro Gly Thr Thr Glu Thr Glu
    530                 535                 540                 
Gln Lys Pro Leu Glu Gly Thr Pro Glu Asn Ile Lys Thr Asn Tyr Gln
545                 550                 555                 560 
Gln Val Gly Met Thr Gly Leu Ser Asp Asp Ala Phe Val Ala Ser Lys
                565                 570                 575     
Lys Leu Asn Asn Thr Ser Ala Leu Ala Ala Met Thr Phe Thr Asn Trp
            580                 585                 590         
Asn Lys Ser Leu Thr Leu Asn Lys Gly Trp Phe Ile Leu Gly Asn Lys
        595                 600                 605             
Ile Ile Phe Val Gly Ser Asn Ile Lys Asn Gln Ser Ser His Lys Ala
    610                 615                 620                 
Tyr Thr Thr Ile Glu Gln Arg Lys Glu Asn Gln Lys Tyr Pro Tyr Cys
625                 630                 635                 640 
Ser Tyr Val Asn Asn Gln Pro Val Asp Leu Asn Asn Gln Leu Val Asp
                645                 650                 655     
Phe Thr Asn Thr Lys Ser Ile Phe Leu Glu Ser Asp Asp Pro Ala Gln
            660                 665                 670         
Asn Ile Gly Tyr Tyr Phe Phe Lys Pro Thr Thr Leu Ser Ile Ser Lys
        675                 680                 685             
Ala Leu Gln Thr Gly Lys Trp Gln Asn Ile Lys Ala Asp Asp Lys Ser
    690                 695                 700                 
Pro Glu Ala Ile Lys Glu Val Ser Asn Thr Phe Ile Thr Ile Met Gln
705                 710                 715                 720 
Asn His Thr Gln Asp Gly Asp Arg Tyr Ala Tyr Met Met Leu Pro Asn
                725                 730                 735     
Met Thr Arg Gln Glu Phe Glu Thr Tyr Ile Ser Lys Leu Asp Ile Asp
            740                 745                 750         
Leu Leu Glu Asn Asn Asp Lys Leu Ala Ala Val Tyr Asp His Asp Ser
        755                 760                 765             
Gln Gln Met His Val Ile His Tyr Gly Lys Lys Ala Thr Met Phe Ser
    770                 775                 780                 
Asn His Asn Leu Ser His Gln Gly Phe Tyr Ser Phe Pro His Pro Val
785                 790                 795                 800 
Arg Gln Asn Gln Gln
                805 


<210> 294
<211> 780
<212> PRT
<213> Streptococcus pyogenes serotype M2 (strain MGAS10270)

<220> 
<223> hyaluronan lyase

<400> 294
Met Val Tyr Phe Tyr Leu Val Asn Gln Ser Thr Phe Ile Ile Ser Phe
 1               5                  10                  15      
Leu Tyr Trp Arg Asn Val Ser Val Asn Thr Tyr Phe Cys Thr His His
            20                  25                  30          
Lys Gln Leu Leu Leu Tyr Ser Asn Leu Phe Leu Ser Phe Ala Met Ile
        35                  40                  45              
Gly Gln Gly Thr Ala Ile Tyr Ala Asp Thr Leu Thr Ser Asn Ser Glu
    50                  55                  60                  
Pro Asn Asn Thr Tyr Phe Gln Thr Gln Thr Leu Thr Thr Thr Asp Ser
65                  70                  75                  80  
Glu Lys Lys Val Val Gln Pro Gln Gln Lys Asp Tyr Tyr Thr Glu Leu
                85                  90                  95      
Leu Asp Gln Trp Asn Ser Ile Ile Ala Gly Asn Asp Ala Tyr Asp Lys
            100                 105                 110         
Thr Asn Pro Asp Met Val Thr Phe His Asn Lys Ala Glu Lys Asp Ala
        115                 120                 125             

Gln Asn Ile Ile Lys Ser Tyr Gln Gly Pro Asp His Glu Asn Arg Thr
    130                 135                 140                 
Tyr Leu Trp Glu His Ala Lys Asp Tyr Ser Ala Ser Thr Asn Ile Thr
145                 150                 155                 160 
Lys Thr Tyr Arg Asn Ile Glu Lys Ile Ala Lys Gln Ile Thr Asn Pro
                165                 170                 175     
Glu Ser Cys Tyr Tyr Gln Asp Ser Lys Ala Ile Ala Ile Val Lys Asp
            180                 185                 190         
Gly Met Ala Phe Met Tyr Glu His Ala Tyr Asn Leu Asn Arg Glu Asn
        195                 200                 205             
His Gln Thr Thr Gly Lys Glu Asn Lys Glu Asn Trp Trp Val Tyr Glu
    210                 215                 220                 
Ile Gly Thr Pro Arg Ala Ile Asn Asn Thr Leu Ser Leu Met Tyr Pro
225                 230                 235                 240 
Tyr Phe Thr Gln Glu Glu Ile Leu Lys Tyr Thr Ala Pro Ile Glu Lys
                245                 250                 255     
Phe Val Pro Asp Pro Thr Arg Phe Arg Val Arg Ala Ala Asn Phe Ser
            260                 265                 270         
Pro Phe Glu Ala Asn Ser Gly Asn Leu Ile Asp Met Gly Arg Val Lys
        275                 280                 285             
Leu Ile Ser Gly Ile Leu Arg Lys Asp Asp Leu Glu Ile Ser Asp Thr
    290                 295                 300                 
Ile Lys Ala Ile Glu Lys Val Phe Thr Leu Val Asp Glu Gly Asn Gly
305                 310                 315                 320 
Phe Tyr Gln Asp Gly Ser Leu Ile Asp His Val Val Thr Asn Thr Gln
                325                 330                 335     
Ser Pro Leu Tyr Lys Lys Gly Ile Ala Tyr Thr Gly Ala Tyr Gly Asn
            340                 345                 350         
Val Leu Ile Asp Gly Leu Ser Gln Leu Ile Pro Ile Ile Gln Lys Thr
        355                 360                 365             
Lys Ser Pro Ile Glu Ala Asp Lys Met Ala Thr Ile Tyr His Trp Ile
    370                 375                 380                 
Asn His Ser Phe Phe Pro Ile Ile Val Arg Gly Glu Met Met Asp Met
385                 390                 395                 400 
Thr Arg Gly Arg Ser Ile Ser Arg Phe Asn Ala Gln Ser His Val Ala
                405                 410                 415     
Gly Ile Glu Ala Leu Arg Ala Ile Leu Arg Ile Ala Asp Met Ser Glu
            420                 425                 430         
Glu Pro His Arg Leu Glu Leu Lys Thr Arg Ile Lys Thr Leu Val Thr
        435                 440                 445             
Gln Gly Asn Ala Phe Tyr Asn Val Tyr Asp Asn Leu Lys Thr Tyr His
    450                 455                 460                 
Asp Ile Lys Leu Met Lys Glu Leu Leu Ser Asp Thr Ser Val Pro Val

465                 470                 475                 480 
Gln Lys Leu Asp Ser Tyr Val Ala Ser Phe Asn Ser Met Asp Lys Leu
                485                 490                 495     
Ala Leu Tyr Asn Asn Lys His Asp Phe Ala Phe Gly Leu Ser Met Phe
            500                 505                 510         
Ser Asn Arg Thr Gln Asn Tyr Glu Ala Met Asn Asn Glu Asn Leu His
        515                 520                 525             
Gly Trp Phe Thr Ser Asp Gly Met Phe Tyr Leu Tyr Asn Asn Asp Leu
    530                 535                 540                 
Gly His Tyr Ser Glu Asn Tyr Trp Ala Thr Val Asn Pro Tyr Arg Leu
545                 550                 555                 560 
Pro Gly Thr Thr Glu Thr Glu Gln Lys Pro Leu Glu Gly Thr Pro Glu
                565                 570                 575     
Asn Ile Lys Thr Asn Tyr Gln Gln Val Gly Met Thr Ser Leu Ser Asp
            580                 585                 590         
Asp Ala Phe Val Ala Ser Lys Lys Leu Asn Asn Thr Ser Ala Leu Ala
        595                 600                 605             
Ala Met Thr Phe Thr Asn Trp Asn Lys Ser Leu Thr Leu Asn Lys Gly
    610                 615                 620                 
Trp Phe Ile Leu Gly Asn Lys Ile Ile Phe Val Gly Ser Asn Ile Lys
625                 630                 635                 640 
Asn Gln Ser Ser His Lys Ala Tyr Thr Thr Ile Glu Gln Arg Lys Glu
                645                 650                 655     
Asn Gln Lys His Pro Tyr Cys Ser Tyr Val Asn Asn Gln Pro Val Asp
            660                 665                 670         
Leu Asn Asn Gln Leu Val Asp Phe Thr Asn Thr Lys Ser Ile Phe Leu
        675                 680                 685             
Glu Ser Asp Asp Pro Ala Gln Asn Ile Gly Tyr Tyr Phe Phe Lys Pro
    690                 695                 700                 
Arg Thr Leu Ser Ile Ser Lys Ala Leu Gln Thr Gly Lys Trp Gln Asn
705                 710                 715                 720 
Ile Lys Ala Asp Asp Lys Ser Pro Glu Ala Ile Lys Glu Val Ser Asn
                725                 730                 735     
Thr Phe Ile Thr Ile Met Gln Asn His Thr Gln Glu Gly Asp Arg Tyr
            740                 745                 750         
Ala Tyr Met Met Leu Pro Asn Met Thr Arg Gln Glu Phe Glu Thr Tyr
        755                 760                 765             
Ile Ser Lys Leu Asp Ile Asp Leu Leu Glu Asn Asn
    770                 775                 780 


<210> 295
<211> 868
<212> PRT
<213> Streptococcus pyogenes serotype M4 (strain MGAS10750)

<220> 
<223> hyaluronan lyase

<400> 295
Met Asn Thr Tyr Phe Cys Thr His His Lys Gln Leu Leu Leu Tyr Ser
 1               5                  10                  15      
Asn Leu Phe Leu Ser Phe Ala Met Met Gly Gln Gly Thr Ala Ile Tyr
            20                  25                  30          
Ala Asp Thr Leu Thr Ser Asn Ser Lys Pro Asn Asn Thr Tyr Phe Gln
        35                  40                  45              
Thr Gln Thr Leu Thr Thr Thr Asp Ser Glu Lys Lys Val Val Gln Pro
    50                  55                  60                  
Gln Gln Lys Asp Tyr Tyr Thr Glu Leu Leu Asp Gln Trp Asn Ser Ile
65                  70                  75                  80  
Ile Ala Gly Asn Asp Ala Tyr Asp Lys Thr Asn Pro Asp Met Val Thr
                85                  90                  95      
Phe His Asn Lys Ala Glu Lys Asp Ala Gln Asn Ile Ile Lys Ser Tyr
            100                 105                 110         
Gln Glu Pro Asp His Glu Asn Arg Thr Tyr Leu Trp Glu His Ala Lys
        115                 120                 125             
Asp Tyr Ser Ala Ser Ala Asn Ile Thr Lys Thr Tyr Arg Asn Ile Glu
    130                 135                 140                 
Lys Ile Ala Lys Gln Ile Thr Asn Pro Glu Ser Cys Tyr Tyr Gln Asp
145                 150                 155                 160 
Ser Lys Ala Ile Ala Ile Val Lys Asp Gly Met Ala Phe Met Tyr Glu
                165                 170                 175     
His Ala Tyr Asn Leu Asp Arg Glu Asn His Gln Thr Thr Gly Lys Glu
            180                 185                 190         
Asn Lys Glu Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro Arg Ala Ile
        195                 200                 205             
Asn Asn Thr Leu Ser Leu Met Tyr Pro Tyr Phe Thr Gln Glu Glu Ile
    210                 215                 220                 
Leu Lys Tyr Thr Ala Pro Ile Glu Lys Phe Val Pro Asp Pro Thr Arg
225                 230                 235                 240 
Phe Arg Val Arg Ala Ala Asn Phe Pro Pro Phe Glu Ala Asn Ser Gly
                245                 250                 255     
Asn Leu Ile Asp Met Gly Arg Val Lys Leu Ile Ser Gly Ile Leu Arg
            260                 265                 270         
Lys Asp Asp Leu Glu Ile Ser Asp Thr Ile Lys Ala Ile Glu Lys Val
        275                 280                 285             
Phe Thr Leu Val Asp Glu Gly Asn Gly Phe Tyr Gln Asp Gly Ser Leu
    290                 295                 300                 
Ile Asp His Val Val Thr Asn Ala Gln Ser Pro Leu Tyr Lys Lys Gly
305                 310                 315                 320 
Ile Ala Tyr Thr Gly Ala Tyr Gly Asn Val Leu Ile Asp Gly Leu Ser
                325                 330                 335     
Gln Leu Ile Pro Ile Ile Gln Lys Thr Lys Ser Pro Ile Glu Ala Asp
            340                 345                 350         
Lys Met Ala Thr Ile Tyr His Trp Ile Asn His Ser Phe Phe Pro Ile
        355                 360                 365             
Ile Val Arg Gly Glu Met Met Asp Met Thr Arg Gly Arg Ser Ile Ser
    370                 375                 380                 
Arg Phe Asn Ala Gln Ser His Val Ala Gly Ile Glu Ala Leu Arg Ala
385                 390                 395                 400 
Ile Leu Arg Ile Ala Asp Met Ser Glu Glu Pro His Arg Leu Ala Leu
                405                 410                 415     
Lys Thr Arg Ile Lys Thr Leu Val Thr Gln Gly Asn Val Phe Tyr Asn
            420                 425                 430         
Val Tyr Asp Asn Leu Lys Thr Tyr His Asp Ile Lys Leu Met Lys Glu
        435                 440                 445             
Leu Leu Ser Asp Thr Ser Val Pro Val Gln Lys Leu Asp Ser Tyr Val
    450                 455                 460                 
Ala Ser Phe Asn Ser Met Asp Lys Leu Ala Leu Tyr Asn Asn Lys His
465                 470                 475                 480 
Asp Phe Ala Phe Gly Leu Ser Met Phe Ser Asn Arg Thr Gln Asn Tyr
                485                 490                 495     
Glu Ala Met Asn Asn Glu Asn Leu His Gly Trp Phe Thr Ser Asp Gly
            500                 505                 510         
Met Phe Tyr Leu Tyr Asn Asn Asp Leu Gly His Tyr Ser Glu Asn Tyr
        515                 520                 525             
Trp Ala Thr Val Asn Pro Tyr Arg Leu Pro Gly Thr Thr Glu Thr Glu
    530                 535                 540                 
Gln Lys Pro Leu Glu Gly Thr Pro Glu Asn Ile Lys Thr Asn Tyr Gln
545                 550                 555                 560 
Gln Val Gly Met Thr Ser Leu Ser Asp Asp Ala Phe Val Ala Ser Lys
                565                 570                 575     
Lys Leu Asn Asn Thr Ser Ala Leu Ala Ala Met Thr Phe Thr Asn Trp
            580                 585                 590         
Asn Lys Ser Leu Thr Leu Asn Lys Gly Trp Phe Ile Leu Gly Asn Lys
        595                 600                 605             
Ile Ile Phe Val Gly Ser Asn Ile Lys Asn Gln Ser Ser His Lys Ala
    610                 615                 620                 
Tyr Thr Thr Ile Glu Gln Arg Lys Glu Asn Gln Lys His Pro Tyr Cys
625                 630                 635                 640 
Ser Tyr Val Asn Asn Gln Pro Val Asp Leu Asn Asn Gln Leu Val Asp
                645                 650                 655     
Phe Thr Asn Thr Lys Ser Ile Phe Leu Glu Ser Asp Asp Pro Ala Gln
            660                 665                 670         
Asn Ile Gly Tyr Tyr Phe Phe Lys Pro Thr Thr Leu Ser Ile Ser Lys
        675                 680                 685             
Ala Leu Gln Thr Gly Lys Trp Gln Asn Ile Lys Ala Asp Asp Lys Ser
    690                 695                 700                 
Pro Glu Ala Ile Lys Glu Val Ser Asn Thr Phe Ile Thr Ile Met Gln
705                 710                 715                 720 
Asn His Thr Gln Asp Gly Asp Arg Tyr Ala Tyr Met Met Leu Pro Asn
                725                 730                 735     
Met Thr Arg Gln Glu Phe Glu Thr Tyr Ile Ser Lys Leu Asp Ile Asp
            740                 745                 750         
Leu Leu Glu Asn Asn Asp Lys Leu Ala Ala Val Tyr Asp His Asp Ser
        755                 760                 765             
Gln Gln Met His Val Ile His Tyr Glu Lys Lys Ala Thr Thr Phe Ser
    770                 775                 780                 
Asn His Asn Leu Ser His Gln Gly Phe Tyr Ser Phe Pro His Pro Val
785                 790                 795                 800 

Lys Gln Asn Gln Gln Gln Lys Leu Ala His Gln Gly Ile Ala Ala Lys
                805                 810                 815     
Asn Asn Ala Leu Asn Ser His Lys Ile Pro His Lys Arg Gln Arg Arg
            820                 825                 830         
Leu Pro Arg Thr Gly Tyr Gln Ser Ser Ser Leu Glu Phe Leu Gly Gly
        835                 840                 845             
Ala Leu Val Ala Ser Phe Asn His Ile Thr Lys Pro Phe Arg Lys Lys
    850                 855                 860                 
Asp Leu Arg Ile
865             


<210> 296
<211> 828
<212> PRT
<213> Streptococcus pyogenes serotype M6

<220> 
<223> hyaluronan lyase

<400> 296
Met Val Tyr Phe Tyr Leu Val Asp Gln Phe Thr Phe Ile Ile Ser Phe
 1               5                  10                  15      
Leu Tyr Trp Arg Asn Leu Ser Val Asn Thr Tyr Phe Cys Thr His His
            20                  25                  30          
Lys Gln Leu Leu Leu Tyr Ser Asn Leu Phe Leu Ser Phe Ala Met Met
        35                  40                  45              
Gly Gln Gly Thr Ala Ile Tyr Ala Asp Thr Leu Thr Ser Asn Ser Glu
    50                  55                  60                  
Pro Asn Asn Thr Tyr Phe Gln Thr Gln Thr Leu Thr Thr Thr Asp Ser
65                  70                  75                  80  
Glu Lys Lys Val Val Gln Pro Gln Gln Lys Asp Tyr Tyr Thr Glu Leu
                85                  90                  95      
Leu Asp Gln Trp Asn Ser Ile Ile Ala Gly Asn Asp Ala Tyr Asp Lys
            100                 105                 110         
Thr Asn Pro Asp Met Val Thr Phe His Asn Lys Ala Glu Lys Asp Ala
        115                 120                 125             
Gln Asn Ile Ile Lys Ser Tyr Gln Gly Pro Asp His Glu Asn Arg Thr
    130                 135                 140                 
Tyr Leu Trp Glu His Ala Lys Asp Tyr Ser Ala Ser Thr Asn Ile Thr
145                 150                 155                 160 
Lys Thr Tyr Arg Asn Ile Glu Lys Ile Ala Lys Gln Ile Thr Asn Pro
                165                 170                 175     
Glu Ser Cys Tyr Tyr Gln Asp Ser Lys Ala Ile Ala Ile Val Lys Asp
            180                 185                 190         
Gly Met Ala Phe Met Tyr Glu His Ala Tyr Asn Leu Asp Arg Glu Asn
        195                 200                 205             
His Gln Thr Thr Gly Lys Glu Asn Lys Glu Asn Trp Trp Val Tyr Glu
    210                 215                 220                 
Ile Gly Thr Pro Arg Ala Ile Asn Asn Thr Leu Ser Leu Met Tyr Pro
225                 230                 235                 240 
Tyr Phe Thr Gln Glu Glu Ile Leu Lys Tyr Thr Ala Pro Ile Glu Lys
                245                 250                 255     
Phe Val Pro Asp Pro Thr Arg Phe Arg Val Arg Ala Ala Asn Phe Ser
            260                 265                 270         
Pro Phe Glu Ala Asn Ser Gly Asn Leu Ile Asp Met Gly Arg Val Lys
        275                 280                 285             
Leu Ile Ser Gly Ile Leu Arg Lys Asp Asp Leu Glu Ile Ser Asp Thr
    290                 295                 300                 
Ile Lys Ala Ile Glu Lys Val Phe Thr Leu Val Asp Glu Gly Asn Gly
305                 310                 315                 320 
Phe Tyr Gln Asp Gly Ser Leu Ile Asp His Val Val Thr Asn Ala Gln
                325                 330                 335     
Ser Pro Leu Tyr Lys Lys Gly Ile Ala Tyr Thr Gly Ala Tyr Gly Asn
            340                 345                 350         
Val Leu Ile Asp Gly Leu Ser Gln Leu Ile Pro Ile Ile Gln Lys Thr
        355                 360                 365             
Lys Ser Pro Ile Glu Ala Asp Lys Met Ala Thr Ile Tyr His Trp Ile
    370                 375                 380                 
Asn His Ser Phe Phe Pro Ile Ile Val Arg Gly Glu Met Met Asp Met
385                 390                 395                 400 
Thr Arg Gly Arg Ser Ile Ser Arg Phe Asn Ala Gln Ser His Val Ala
                405                 410                 415     
Gly Ile Glu Ala Leu Arg Ala Ile Leu Arg Ile Ala Asp Met Ser Glu
            420                 425                 430         
Glu Pro His Arg Leu Ala Leu Lys Thr Arg Ile Lys Thr Leu Val Thr
        435                 440                 445             
Gln Gly Asn Ala Phe Tyr Asn Val Tyr Asp Asn Leu Lys Thr Tyr His
    450                 455                 460                 
Asp Ile Lys Leu Met Lys Glu Leu Leu Ser Asp Thr Phe Val Pro Val
465                 470                 475                 480 
Gln Lys Leu Asp Ser Tyr Val Ala Ser Phe Asn Ser Met Asp Lys Leu
                485                 490                 495     
Ala Leu Tyr Asn Asn Lys His Asp Phe Ala Phe Gly Leu Ser Met Phe
            500                 505                 510         
Ser Asn Arg Thr Gln Asn Tyr Glu Ala Met Asn Asn Glu Asn Leu His
        515                 520                 525             
Gly Trp Phe Thr Ser Asp Gly Met Phe Tyr Leu Tyr Asn Asn Asp Leu
    530                 535                 540                 
Gly His Tyr Ser Glu Asn Tyr Trp Ala Thr Val Asn Pro Tyr Arg Leu
545                 550                 555                 560 
Pro Gly Thr Thr Glu Thr Glu Gln Lys Pro Leu Glu Gly Thr Pro Glu
                565                 570                 575     
Asn Ile Lys Thr Asp Tyr Gln Gln Val Gly Met Thr Ser Leu Ser Asp
            580                 585                 590         
Asp Ala Phe Val Ala Ser Lys Lys Leu Asn Asn Thr Ser Ala Leu Ala
        595                 600                 605             
Ala Met Thr Phe Thr Asn Trp Asn Lys Ser Leu Thr Leu Asn Lys Gly
    610                 615                 620                 
Trp Phe Ile Leu Gly Asn Lys Ile Ile Phe Val Gly Ser Asn Ile Lys
625                 630                 635                 640 
Asn Gln Ser Ser His Lys Ala Tyr Thr Thr Ile Glu Gln Arg Lys Glu
                645                 650                 655     
Asn Gln Lys His Pro Tyr Cys Ser Tyr Val Asn Asn Gln Pro Val Asp
            660                 665                 670         
Leu Asn Asn Gln Leu Val Asp Phe Thr Asn Thr Lys Ser Ile Phe Leu
        675                 680                 685             
Glu Ser Asp Asp Pro Ala Gln Asn Ile Gly Tyr Tyr Phe Phe Lys Pro
    690                 695                 700                 
Thr Thr Leu Ser Ile Ser Lys Ala Leu Gln Thr Gly Lys Trp Gln Asn
705                 710                 715                 720 
Ile Lys Ala Asp Asp Lys Ser Pro Glu Ala Ile Lys Glu Val Ser Asn
                725                 730                 735     
Thr Phe Ile Thr Ile Met Gln Asn His Thr Gln Asp Gly Asp Arg Tyr
            740                 745                 750         
Ala Tyr Met Met Leu Pro Asn Met Thr Arg Gln Glu Phe Glu Thr Tyr
        755                 760                 765             
Ile Ser Lys Leu Asp Ile Asp Leu Leu Glu Asn Asn Asp Lys Leu Ala
    770                 775                 780                 
Ala Val Tyr Asp His Asp Ser Gln Gln Met His Val Ile His Tyr Glu
785                 790                 795                 800 
Lys Lys Ala Thr Met Phe Ser Asn His Asn Leu Ser His Gln Gly Phe
                805                 810                 815     
Tyr Ser Phe Pro His Pro Val Lys Gln Asn Gln Gln
            820                 825             


<210> 297
<211> 556
<212> PRT
<213> Streptococcus pyogenes serotype M12 (strain MGAS2096)

<220> 
<223> hyaluronan lyase

<400> 297
Met Val Tyr Phe Tyr Leu Val Asn Gln Ser Thr Phe Ile Ile Ser Phe
 1               5                  10                  15      
Leu Tyr Trp Arg Asn Leu Ser Val Asn Thr Tyr Phe Cys Thr His His
            20                  25                  30          
Lys Gln Leu Leu Leu Tyr Ser Asn Leu Phe Leu Ser Phe Ala Met Met
        35                  40                  45              
Gly Gln Gly Thr Ala Ile Tyr Ala Asp Thr Leu Thr Ser Asn Ser Glu
    50                  55                  60                  
Pro Asn Asn Thr Tyr Phe Gln Thr Gln Thr Leu Thr Thr Thr Asp Ser
65                  70                  75                  80  
Glu Lys Lys Val Val Gln Pro Gln Gln Lys Asp Tyr Tyr Thr Glu Leu
                85                  90                  95      
Leu Asp Gln Trp Asn Ser Ile Ile Ala Gly Asn Asp Ala Tyr Asp Lys
            100                 105                 110         
Thr Asn Pro Asp Met Val Thr Phe His Asn Lys Ala Glu Lys Asp Ala
        115                 120                 125             
Gln Asn Ile Ile Lys Ser Tyr Gln Gly Pro Asp His Glu Asn Arg Thr
    130                 135                 140                 
Tyr Leu Gly Asn Met Gln Arg Ile Ile Pro Leu Leu Leu Ile Ser Arg
145                 150                 155                 160 
Lys Leu Thr Ala Ile Leu Lys Lys Ile Ser Lys Met Lys Ser Leu Met
                165                 170                 175     
Glu Asp Ser Thr Ile Ser Thr Asn Gly Leu Thr Gln Gln Leu Lys Ile
            180                 185                 190         
Tyr Asn Asp Met Asp Arg Val Thr Tyr His Asn Lys Gly Leu Asp Phe
        195                 200                 205             
Ala Phe Gly Leu Ser Met Thr Ser Lys Asn Val Ala Arg Tyr Glu Ser
    210                 215                 220                 
Ile Asn Gly Glu Asn Leu Lys Gly Trp His Thr Gly Ala Gly Met Ser
225                 230                 235                 240 
Tyr Leu Tyr Asn Ser Asp Val Lys His Tyr Arg Asp Asn Phe Trp Ala
                245                 250                 255     
Thr Ala Asp Met Lys Arg Leu Ala Gly Thr Thr Thr Leu Asp Asn Glu
            260                 265                 270         
Glu Pro Lys Ser Thr Asp Val Lys Lys Ser Ser Lys Thr Phe Val Gly
        275                 280                 285             
Gly Thr Lys Phe Asp Asp Gln His Ala Ser Ile Gly Met Asp Phe Glu
    290                 295                 300                 
Asn Gln Asp Lys Thr Leu Thr Ala Lys Lys Ser Tyr Phe Ile Leu Asn
305                 310                 315                 320 
Asp Lys Ile Val Phe Leu Gly Thr Gly Ile Lys Ser Thr Asp Ser Ser
                325                 330                 335     
Lys Asn Pro Val Thr Thr Ile Glu Asn Arg Lys Ala Asn Asp Tyr Lys
            340                 345                 350         
Leu Tyr Lys Asp Asp Thr Gln Thr Thr Asn Ser Asp Asn Gln Glu Thr
        355                 360                 365             
Asn Ser Leu Phe Leu Glu Ser Thr Asn Ser Thr Gln Asn Asn Ile Gly
    370                 375                 380                 
Tyr His Phe Leu Asn Glu Ser Lys Ile Thr Val Lys Lys Glu Ser His
385                 390                 395                 400 
Thr Gly Lys Trp Ser Asp Ile Asn Lys Ser Gln Lys Asp Ile Gln Lys
                405                 410                 415     
Thr Asp Glu Tyr Tyr Glu Val Thr Gln Lys His Ser Asn Thr Asp Ser
            420                 425                 430         
Lys Tyr Ala Tyr Val Leu Tyr Pro Gly Leu Ser Lys Asp Val Phe Lys
        435                 440                 445             
Ser Lys Ala Ser Lys Val Thr Val Val Lys Gln Glu Asp Asp Phe His
    450                 455                 460                 
Val Val Lys Asp Asn Glu Ser Val Trp Ala Gly Ile Asn Tyr Ser Asp
465                 470                 475                 480 
Ser Ala Lys Thr Phe Glu Ile Asn Asn Thr Lys Val Glu Val Lys Ala
                485                 490                 495     
Lys Gly Met Phe Ile Leu Thr Lys Lys Asp Asp Asn Thr Tyr Glu Cys
            500                 505                 510         
Ser Phe Tyr Asn Pro Glu Ser Thr Asn Ser Val Ser Asp Ile Glu Ser
        515                 520                 525             
Lys Ile Ser Met Thr Gly Tyr Ser Ile Ile Asn Lys Asn Thr Ser Thr
    530                 535                 540                 
Ser Asn Glu Ser Gly Val Arg Phe Glu Leu Thr Lys
545                 550                 555     


<210> 298
<211> 635
<212> PRT
<213> Streptococcus pyogenes serotype M12 (strain MGAS2096)

<220> 
<223> hyaluronan lyase

<400> 298
Met Ala Phe Met Tyr Glu His Ala Tyr Asn Leu Asn Arg Glu Asn His
 1               5                  10                  15      
Gln Thr Thr Gly Lys Glu Asn Lys Glu Asn Trp Trp Val Tyr Glu Ile
            20                  25                  30          
Gly Thr Pro Arg Ala Ile Asn Asn Thr Leu Ser Leu Met Tyr Pro Tyr
        35                  40                  45              
Phe Thr Gln Glu Glu Ile Leu Lys Tyr Thr Ala Pro Ile Glu Lys Phe
    50                  55                  60                  
Val Pro Asp Pro Thr Arg Phe Arg Val Arg Ala Ala Asn Phe Ser Pro
65                  70                  75                  80  
Phe Glu Ala Ser Ser Gly Asn Leu Ile Asp Met Gly Arg Val Lys Leu
                85                  90                  95      
Ile Ser Gly Ile Leu Arg Lys Asp Asp Leu Glu Ile Ser Asp Thr Ile
            100                 105                 110         
Lys Ala Ile Glu Lys Val Phe Thr Leu Val Asp Glu Gly Asn Gly Phe
        115                 120                 125             
Tyr Gln Asp Gly Ser Leu Ile Asp His Val Val Thr Asn Ala Gln Ser
    130                 135                 140                 
Pro Leu Tyr Lys Lys Gly Ile Ala Tyr Thr Gly Ala Tyr Gly Asn Val
145                 150                 155                 160 
Leu Ile Asp Gly Leu Ser Gln Leu Ile Pro Ile Ile Gln Lys Thr Lys
                165                 170                 175     
Ser Pro Ile Glu Ala Asp Lys Met Ala Thr Ile Tyr His Trp Ile Asn
            180                 185                 190         
His Ser Phe Phe Pro Ile Ile Val Arg Gly Glu Met Met Asp Met Thr
        195                 200                 205             
Arg Gly Arg Ser Ile Ser Arg Phe Asn Ala Gln Ser His Val Ala Gly
    210                 215                 220                 
Ile Glu Ala Leu Arg Ala Ile Leu Arg Ile Ala Asp Met Ser Glu Glu
225                 230                 235                 240 
Pro His Arg Leu Ala Leu Lys Thr Arg Ile Lys Thr Leu Val Thr Gln
                245                 250                 255     
Gly Asn Ala Phe Tyr Asn Val Tyr Asp Asn Leu Lys Thr Tyr His Asp
            260                 265                 270         
Ile Lys Leu Met Lys Glu Leu Leu Ser Asp Thr Ser Val Pro Val Gln
        275                 280                 285             
Lys Leu Asp Ser Tyr Val Ala Ser Phe Asn Ser Met Asp Lys Leu Ala
    290                 295                 300                 
Leu Tyr Asn Asn Lys His Asp Phe Ala Phe Gly Leu Ser Met Phe Ser
305                 310                 315                 320 
Asn Arg Thr Gln Asn Tyr Glu Ala Met Asn Asn Glu Asn Leu His Gly
                325                 330                 335     
Trp Phe Thr Ser Asp Gly Met Phe Tyr Leu Tyr Asn Asn Asp Leu Gly
            340                 345                 350         
His Tyr Ser Glu Asn Tyr Trp Ala Thr Val Asn Pro Tyr Arg Leu Pro
        355                 360                 365             
Gly Thr Thr Glu Thr Glu Gln Lys Pro Leu Glu Gly Thr Pro Glu Asn
    370                 375                 380                 
Ile Lys Thr Asn Tyr Gln Gln Val Gly Met Thr Ser Leu Ser Asp Asp
385                 390                 395                 400 
Ala Phe Val Ala Ser Lys Lys Leu Asn Asn Thr Ser Ala Leu Ala Ala
                405                 410                 415     
Met Thr Phe Thr Asn Trp Asn Lys Ser Leu Thr Leu Asn Lys Gly Trp
            420                 425                 430         
Phe Ile Leu Gly Asn Lys Ile Ile Phe Val Gly Ser Asn Ile Lys Asn
        435                 440                 445             
Gln Ser Ser His Lys Ala Tyr Thr Thr Ile Glu Gln Arg Lys Glu Asn
    450                 455                 460                 
Gln Lys His Pro Tyr Cys Ser Tyr Val Asn Asn Gln Pro Val Asp Leu
465                 470                 475                 480 
Asn Asn Gln Leu Val Asp Phe Thr Asn Thr Lys Ser Ile Phe Leu Glu
                485                 490                 495     
Ser Asp Asp Pro Ala Gln Asn Ile Gly Tyr Tyr Phe Phe Lys Pro Thr
            500                 505                 510         
Thr Leu Ser Ile Ser Lys Ala Leu Gln Thr Gly Lys Trp Gln Asn Ile
        515                 520                 525             
Lys Ala Asp Asp Lys Ser Pro Glu Ala Ile Lys Glu Val Ser Asn Thr
    530                 535                 540                 
Phe Ile Thr Ile Met Gln Asn His Thr Gln Asp Gly Asp Arg Tyr Ala
545                 550                 555                 560 
Tyr Met Met Leu Pro Asn Met Thr Arg Gln Glu Phe Glu Thr Tyr Ile
                565                 570                 575     
Ser Lys Leu Asp Ile Asp Leu Leu Glu Asn Asn Asp Lys Leu Ala Ala
            580                 585                 590         
Val Tyr Asp His Asp Ser Gln Gln Met His Val Ile His Tyr Glu Lys
        595                 600                 605             
Lys Ala Thr Met Phe Ser Asn His Asn Leu Ser His Gln Gly Phe Tyr
    610                 615                 620                 
Ser Phe Pro His Pro Val Lys Gln Asn Gln Gln
625                 630                 635 


<210> 299
<211> 828
<212> PRT
<213> Streptococcus pyogenes serotype M12 (strain MGAS9429)

<220> 
<223> hyaluronan lyase

<400> 299
Met Val Tyr Phe Tyr Leu Val Asn Gln Ser Thr Phe Ile Ile Ser Phe
 1               5                  10                  15      
Leu Tyr Trp Arg Asn Leu Ser Val Asn Thr Tyr Phe Cys Thr His His
            20                  25                  30          
Lys Gln Leu Leu Leu Tyr Ser Asn Leu Phe Leu Ser Phe Ala Met Met
        35                  40                  45              
Gly Gln Gly Thr Ala Ile Tyr Ala Asp Thr Leu Thr Ser Asn Ser Glu
    50                  55                  60                  
Pro Asn Asn Thr Tyr Phe Gln Thr Gln Thr Leu Thr Thr Thr Asp Ser
65                  70                  75                  80  
Glu Lys Lys Val Val Gln Pro Gln Gln Lys Asp Tyr Tyr Thr Glu Leu
                85                  90                  95      
Leu Asp Gln Trp Asn Ser Ile Ile Ala Gly Asn Asp Ala Tyr Val Lys
            100                 105                 110         
Thr Asn Pro Asp Met Val Thr Phe His Asn Lys Ala Glu Lys Asp Ala
        115                 120                 125             
Gln Asn Ile Ile Lys Ser Tyr Gln Gly Pro Asp His Glu Asn Arg Thr
    130                 135                 140                 
Tyr Leu Trp Glu His Ala Lys Asp Tyr Ser Ala Ser Thr Asn Ile Thr
145                 150                 155                 160 
Lys Thr Tyr Arg Asn Ile Glu Lys Ile Ala Lys Gln Ile Thr Asn Pro
                165                 170                 175     
Glu Ser Cys Tyr Tyr Gln Asp Ser Lys Ala Ile Ala Ile Val Lys Asp
            180                 185                 190         
Gly Met Ala Phe Met Tyr Glu His Ala Tyr Asn Leu Asn Arg Glu Asn
        195                 200                 205             
His Gln Thr Thr Gly Lys Glu Asn Lys Glu Asn Trp Trp Val Tyr Glu
    210                 215                 220                 
Ile Gly Thr Pro Arg Ala Ile Asn Asn Thr Leu Ser Leu Met Tyr Pro
225                 230                 235                 240 
Tyr Phe Thr Gln Glu Glu Ile Leu Lys Tyr Thr Ala Pro Ile Glu Lys
                245                 250                 255     
Phe Val Pro Asp Pro Thr Arg Phe Arg Val Arg Ala Ala Asn Phe Ser
            260                 265                 270         
Pro Phe Glu Ala Ser Ser Gly Asn Leu Ile Asp Met Gly Arg Val Lys
        275                 280                 285             
Leu Ile Ser Gly Ile Leu Arg Lys Asp Asp Leu Glu Ile Ser Asp Thr
    290                 295                 300                 
Ile Lys Ala Ile Glu Lys Val Phe Thr Leu Val Asp Glu Gly Asn Gly
305                 310                 315                 320 
Phe Tyr Gln Asp Gly Ser Leu Ile Asp His Val Val Thr Asn Ala Gln
                325                 330                 335     
Ser Pro Leu Tyr Lys Lys Gly Ile Ala Tyr Thr Gly Ala Tyr Gly Asn
            340                 345                 350         
Val Leu Ile Asp Gly Leu Ser Gln Leu Ile Pro Ile Ile Gln Lys Thr
        355                 360                 365             
Lys Ser Pro Ile Glu Ala Asp Lys Met Ala Thr Ile Tyr His Trp Ile
    370                 375                 380                 
Asn His Ser Phe Phe Pro Ile Ile Val Arg Gly Glu Met Met Asp Met
385                 390                 395                 400 
Thr Arg Gly Arg Ser Ile Ser Arg Phe Asn Ala Gln Ser His Val Ala
                405                 410                 415     
Gly Ile Glu Ala Leu Arg Ala Ile Leu Arg Ile Ala Asp Met Ser Glu
            420                 425                 430         
Glu Pro His Arg Leu Ala Leu Lys Thr Arg Ile Lys Thr Leu Val Thr
        435                 440                 445             
Gln Gly Asn Ala Phe Tyr Asn Val Tyr Asp Asn Leu Lys Thr Tyr His
    450                 455                 460                 
Asp Ile Lys Leu Met Lys Glu Leu Leu Ser Asp Thr Ser Val Pro Val
465                 470                 475                 480 
Gln Lys Leu Asp Ser Tyr Val Ala Ser Phe Asn Ser Met Asp Lys Leu
                485                 490                 495     
Ala Leu Tyr Asn Asn Lys His Asp Phe Ala Phe Gly Leu Ser Met Phe
            500                 505                 510         
Ser Asn Arg Thr Gln Asn Tyr Glu Ala Met Asn Asn Glu Asn Leu His
        515                 520                 525             
Gly Trp Phe Thr Ser Asp Gly Met Phe Tyr Leu Tyr Asn Asn Asp Leu
    530                 535                 540                 
Gly His Tyr Ser Glu Asn Tyr Trp Ala Thr Val Asn Pro Tyr Arg Leu
545                 550                 555                 560 
Pro Gly Thr Thr Glu Thr Glu Gln Lys Pro Leu Glu Gly Thr Pro Glu
                565                 570                 575     
Asn Ile Lys Thr Asn Tyr Gln Gln Val Gly Met Thr Ser Leu Ser Asp
            580                 585                 590         
Asp Ala Phe Val Ala Ser Lys Lys Leu Asn Asn Thr Ser Ala Leu Ala
        595                 600                 605             
Ala Met Thr Phe Thr Asn Trp Asn Lys Ser Leu Thr Leu Asn Lys Gly
    610                 615                 620                 
Trp Phe Ile Leu Gly Asn Lys Ile Ile Phe Val Gly Ser Asn Ile Lys
625                 630                 635                 640 
Asn Gln Ser Ser His Lys Ala Tyr Thr Thr Ile Glu Gln Arg Lys Glu
                645                 650                 655     
Asn Gln Lys His Pro Tyr Cys Ser Tyr Val Asn Asn Gln Pro Val Asp
            660                 665                 670         
Leu Asn Asn Gln Leu Val Asp Phe Thr Asn Thr Lys Ser Ile Phe Leu
        675                 680                 685             
Glu Ser Asp Asp Pro Ala Gln Asn Ile Gly Tyr Tyr Phe Phe Lys Pro
    690                 695                 700                 
Thr Thr Leu Ser Ile Ser Lys Ala Leu Gln Thr Gly Lys Trp Gln Asn
705                 710                 715                 720 
Ile Lys Ala Asp Asp Lys Ser Pro Glu Ala Ile Lys Glu Val Ser Asn
                725                 730                 735     
Thr Phe Ile Thr Ile Met Gln Asn His Thr Gln Asp Gly Asp Arg Tyr
            740                 745                 750         
Ala Tyr Met Met Leu Pro Asn Met Thr Arg Gln Glu Phe Glu Thr Tyr
        755                 760                 765             
Ile Ser Lys Leu Asp Ile Asp Leu Leu Glu Asn Asn Asp Lys Leu Ala
    770                 775                 780                 

Ala Val Tyr Asp His Asp Ser Gln Gln Met His Val Ile His Tyr Glu
785                 790                 795                 800 
Lys Lys Ala Thr Met Phe Ser Asn His Asn Leu Ser His Gln Gly Phe
                805                 810                 815     
Tyr Ser Phe Pro His Pro Val Lys Gln Asn Gln Gln
            820                 825             


<210> 300
<211> 828
<212> PRT
<213> Streptococcus pyogenes serotype M28

<220> 
<223> hyaluronan lyase

<400> 300
Met Val Tyr Phe Tyr Leu Val Asn Gln Phe Thr Phe Ile Ile Ser Phe
 1               5                  10                  15      
Leu Tyr Arg Arg Asn Leu Ser Val Asn Thr Tyr Phe Cys Thr His His
            20                  25                  30          
Lys Gln Leu Leu Leu Tyr Ser Asn Leu Phe Leu Ser Phe Ala Met Met
        35                  40                  45              
Gly Gln Gly Thr Ala Ile Tyr Ala Asp Thr Leu Thr Ser Asn Ser Glu
    50                  55                  60                  
Pro Asn Asn Thr Tyr Phe Gln Thr Gln Met Leu Thr Thr Thr Asp Ser
65                  70                  75                  80  
Glu Lys Lys Val Val Gln Pro Gln Gln Lys Asp Tyr Tyr Thr Glu Leu
                85                  90                  95      
Leu Asp Gln Trp Asn Ser Ile Ile Ala Gly Asn Asp Ala Tyr Asp Lys
            100                 105                 110         
Thr Asn Pro Asp Met Val Thr Phe His Asn Lys Ala Glu Lys Asp Ala
        115                 120                 125             
Gln Asn Ile Ile Lys Ser Tyr Gln Gly Pro Asp His Glu Asn Arg Thr
    130                 135                 140                 
Tyr Leu Trp Glu His Ala Lys Asp Tyr Ser Ala Ser Ala Asn Ile Thr
145                 150                 155                 160 
Lys Thr Tyr Arg Asn Ile Glu Lys Ile Ala Lys Gln Ile Thr Asn Pro
                165                 170                 175     
Glu Ser Cys Tyr Tyr Gln Asp Ser Lys Ala Ile Ala Ile Val Lys Asp
            180                 185                 190         
Gly Met Ala Phe Met Tyr Glu His Ala Tyr Asn Leu Asp Arg Glu Asn
        195                 200                 205             
His Gln Thr Thr Gly Lys Glu Asn Lys Glu Asn Trp Trp Val Tyr Glu
    210                 215                 220                 
Ile Gly Thr Pro Arg Ala Ile Asn Asn Thr Leu Ser Leu Met Tyr Pro
225                 230                 235                 240 
Tyr Phe Thr Gln Glu Glu Ile Leu Lys Tyr Thr Ala Pro Ile Glu Lys
                245                 250                 255     
Phe Val Pro Asp Pro Thr Arg Phe Arg Val Arg Ala Ala Asn Phe Ser
            260                 265                 270         
Pro Phe Glu Ala Asn Ser Gly Asn Leu Ile Asp Met Gly Arg Val Lys
        275                 280                 285             
Leu Ile Ser Gly Ile Leu Arg Lys Asp Asp Leu Glu Ile Ser Asp Thr
    290                 295                 300                 
Ile Lys Ala Ile Glu Lys Val Phe Thr Leu Val Asp Glu Gly Asn Gly
305                 310                 315                 320 
Phe Tyr Gln Asp Gly Ser Leu Ile Asp His Val Val Thr Asn Ala Gln
                325                 330                 335     
Ser Pro Leu Tyr Lys Lys Gly Ile Ala Tyr Thr Gly Ala Tyr Gly Asn
            340                 345                 350         
Val Leu Ile Asp Gly Leu Ser Gln Leu Ile Pro Ile Ile Gln Lys Thr
        355                 360                 365             
Lys Ser Ser Ile Glu Ala Asp Lys Met Ala Thr Ile Tyr His Trp Ile
    370                 375                 380                 
Asn His Ser Phe Phe Pro Ile Ile Val Arg Gly Glu Met Met Asp Met
385                 390                 395                 400 
Thr Arg Gly Arg Ser Ile Ser Arg Phe Asn Ala Gln Ser His Val Ala
                405                 410                 415     
Gly Ile Glu Ala Leu Arg Ala Ile Leu Arg Ile Ala Asp Met Ser Glu
            420                 425                 430         
Glu Pro His Arg Leu Ala Leu Lys Thr Arg Ile Lys Thr Leu Val Thr
        435                 440                 445             
Gln Gly Asn Ala Phe Tyr Asn Val Tyr Asp Asn Leu Lys Thr Tyr His
    450                 455                 460                 
Asp Ile Lys Leu Met Lys Glu Leu Leu Ser Asp Thr Ser Val Pro Val
465                 470                 475                 480 
Gln Lys Leu Asp Ser Tyr Val Ala Ser Phe Asn Ser Met Asp Lys Leu
                485                 490                 495     
Ala Leu Tyr Asn Asn Lys His Asp Phe Ala Phe Gly Leu Ser Met Phe
            500                 505                 510         
Ser Asn Arg Thr Gln Asn Tyr Glu Ala Met Asn Asn Glu Asn Leu His
        515                 520                 525             
Gly Trp Phe Thr Ser Asp Gly Met Phe Tyr Leu Tyr Asn Asn Asp Leu
    530                 535                 540                 
Gly His Tyr Ser Glu Asn Tyr Trp Ala Thr Val Asn Pro Tyr Arg Leu
545                 550                 555                 560 
Pro Gly Thr Thr Glu Thr Glu Gln Lys Pro Leu Glu Gly Thr Pro Glu
                565                 570                 575     
Asn Ile Lys Thr Asn Tyr Gln Gln Val Gly Met Thr Ser Leu Ser Asp
            580                 585                 590         
Asp Ala Phe Val Ala Ser Lys Lys Leu Asn Asn Thr Ser Ala Leu Ala
        595                 600                 605             
Ala Met Thr Phe Thr Asn Trp Asn Lys Ser Leu Thr Leu Asn Lys Gly
    610                 615                 620                 
Trp Phe Ile Leu Gly Asn Lys Ile Ile Phe Val Gly Ser Asn Ile Lys
625                 630                 635                 640 
Asn Gln Ser Ser His Lys Ala Tyr Thr Thr Ile Glu Gln Arg Lys Glu
                645                 650                 655     
Asn Gln Lys His Pro Tyr His Ala Tyr Val Asn Asn Gln Pro Val Asp
            660                 665                 670         
Leu Asn Asn Gln Leu Val Asp Phe Thr Asn Thr Lys Ser Ile Phe Leu
        675                 680                 685             
Glu Ser Asp Asp Ser Ala Gln Asn Ile Gly Tyr Tyr Phe Phe Lys Pro
    690                 695                 700                 
Thr Thr Leu Ser Ile Ser Lys Ala Leu Gln Thr Gly Lys Trp Gln Asn
705                 710                 715                 720 
Ile Lys Ala Asp Asp Lys Ser Pro Glu Ala Ile Lys Glu Val Ser Asn
                725                 730                 735     
Thr Phe Ile Thr Ile Met Gln Asn His Thr Gln Asp Gly Asp Arg Tyr
            740                 745                 750         
Ala Tyr Met Met Leu Pro Asn Met Thr Arg Gln Glu Phe Glu Thr Tyr
        755                 760                 765             
Ile Ser Lys Leu Asp Ile Asp Leu Leu Glu Asn Asn Asp Lys Leu Ala
    770                 775                 780                 
Ala Val Tyr Asp His Asp Ser Gln Gln Met His Val Ile His Tyr Glu
785                 790                 795                 800 
Lys Lys Ala Thr Met Phe Ser Asn His Asn Leu Ser His Gln Gly Phe
                805                 810                 815     
Tyr Ser Phe Pro His Pro Val Lys Gln Asn Gln Gln
            820                 825             


<210> 301
<211> 522
<212> PRT
<213> Streptococcus suis

<220> 
<223> hyaluronan lyase

<400> 301
Met Gly Phe Phe Ile Ser Gln Ser Lys Gln His Tyr Gly Ile Arg Lys
 1               5                  10                  15      
Tyr Lys Val Gly Val Cys Ser Ala Leu Ile Ala Leu Ser Ile Leu Gly
            20                  25                  30          
Thr Arg Val Ala Ala Asn Gln Leu Pro Ser Thr Glu Thr Ala Ser Pro
        35                  40                  45              
Gln Ser Ser Gln Leu Val Glu Thr Thr Pro Glu Thr Thr Glu Ala Val
    50                  55                  60                  
Asn Leu Thr Thr Glu Ala Val Met Thr Ser Glu Val Ser Ser Glu Val
65                  70                  75                  80  
Ser Pro Val Thr Ser Thr Glu Thr Gln Pro Ser Ser Thr Ala Ala Glu
                85                  90                  95      
Thr Leu Ala Ser Pro Gln Ala Val Gln Ala Thr Lys Glu Glu Glu Lys
            100                 105                 110         
Asn Leu Val Ala Asn Gly Glu Phe Ala Ser Thr Thr Ala Ala Ser Gly
        115                 120                 125             
Asn Trp Ala Asp Pro Ala Ala Thr Asn Trp Glu Thr Trp Ile Pro Ala
    130                 135                 140                 
Asn Val Lys Lys Glu Asn Gly Gln Val Arg Ile Asp Glu Gly Arg Leu
145                 150                 155                 160 
His Ile Ser Ser Thr Ala Ser Tyr Arg Val Ala Val His Gln Thr Val
                165                 170                 175     
Asp Val Asp Pro Asn Lys Arg Tyr Leu Phe Ser Tyr Asn Val Glu Thr
            180                 185                 190         
Lys Asp Leu Lys Gly Ser Gly Val Arg Val Arg Leu Arg Ser Leu Thr
        195                 200                 205             
Ala Glu Gly Lys Asp Leu Ser Pro Gln Glu Phe Ala Tyr Thr Pro Tyr
    210                 215                 220                 
Lys Asn Gly Ser Gln Ala Glu His Ile Glu Gln Ile Leu Thr Val Ser
225                 230                 235                 240 
Pro Glu Thr Arg Lys Leu Lys Val Glu Leu Phe Phe Glu Asn Ser Val
                245                 250                 255     
Gly Gln Ala Trp Leu Asp Asn Ile Ser Leu Val Glu Tyr Val Glu Lys
            260                 265                 270         
Thr Pro Glu Thr Pro Glu Pro Ser Leu Glu Leu Val Gln Pro Glu Thr
        275                 280                 285             
Gly Gln Ile Ser Leu Ala Ser Asn Lys Val Tyr Leu Pro Val Arg Pro
    290                 295                 300                 
Asp Leu Thr Tyr Arg Ile Ala Asp Ala Ala Val Ala Ile Val Glu Lys
305                 310                 315                 320 
Asn Met Ile Arg Pro Leu Ala Ala Gly Lys Thr Gln Val Asp Val Tyr
                325                 330                 335     
Asp Lys Asp Thr Lys Leu Ser Ser Phe Glu Leu Thr Val Thr Glu His
            340                 345                 350         
Gln Ala Thr Val Phe Asp Thr Leu Arg Asn Asn Trp Glu Asp Ile Ser
        355                 360                 365             
Leu Ala Asn Lys Arg Tyr Gln Ser Asn Asp Thr Gln Met Lys Ala Phe
    370                 375                 380                 
Leu Gly Arg Leu Asp Ala Gly Val Ala Ser Ser Leu Lys Lys Trp Val
385                 390                 395                 400 
Glu Pro Thr Asn Gln Gly Lys Thr Ile Phe Asn Asp Ile Asp Phe Ser
                405                 410                 415     
Lys Ser Ser His Leu Thr Thr Val Tyr Arg Arg Leu Glu Gln Met Ala
            420                 425                 430         
Gln Val Val Glu Asn Pro Asp Ser Ala Tyr Tyr His Asp Arg Ser Leu
        435                 440                 445             
Ile Asp Leu Val Arg Lys Gly Met Asn Trp Leu Tyr Thr Asn Val Tyr
    450                 455                 460                 
Asn Glu Asn Lys Ser Ile Asp Gly Asn Trp Trp Asp Tyr Glu Ile Gly
465                 470                 475                 480 
Thr Pro Arg Ala Val Val Asn Thr Leu Ile Tyr Met His Pro Tyr Phe
                485                 490                 495     
Ser Gln Glu Glu Ile Leu Thr Tyr Thr Lys Pro Ile Ser Lys Phe Val
            500                 505                 510         
Pro Asp Pro Thr Thr Ile Ser Val Lys His
        515                 520         


<210> 302
<211> 1164
<212> PRT
<213> Streptococcus suis

<220> 
<223> hyaluronan lyase

<400> 302
Met Gly Phe Phe Ile Ser Gln Ser Lys Gln His Tyr Gly Ile Arg Lys
 1               5                  10                  15      
Tyr Lys Val Gly Val Cys Ser Ala Leu Ile Ala Leu Ser Ile Leu Gly
            20                  25                  30          
Thr Arg Val Ala Ala Asn Gln Leu Pro Ser Thr Glu Thr Ala Ser Pro
        35                  40                  45              
Gln Ser Ser Gln Leu Val Glu Thr Thr Pro Glu Thr Thr Glu Ala Val
    50                  55                  60                  
Met Thr Ser Glu Val Ser Ser Glu Val Ser Pro Val Thr Ser Thr Glu
65                  70                  75                  80  
Thr Gln Pro Ser Ser Thr Thr Ala Glu Thr Leu Ala Ser Pro Gln Ala
                85                  90                  95      

Val Gln Ala Thr Lys Glu Glu Lys Asn Leu Val Ala Asn Gly Glu Phe
            100                 105                 110         
Ile Ser Thr Thr Ala Pro Ser Gly Asn Trp Lys Glu Leu Ala Ala Thr
        115                 120                 125             
Asn Trp Glu Thr Trp Ile Pro Ala Asn Val Lys Lys Glu Asn Gly Gln
    130                 135                 140                 
Val Arg Ile Asp Glu Gly Arg Leu His Ile Ser Ser Thr Ala Ser Tyr
145                 150                 155                 160 
Arg Val Ala Val His Gln Thr Val Asp Val Asp Pro Asn Lys Arg Tyr
                165                 170                 175     
Leu Phe Ser Tyr Asp Val Glu Thr Lys Asp Leu Lys Gly Ser Gly Val
            180                 185                 190         
Arg Val Arg Leu Arg Ser Leu Thr Ala Glu Gly Lys Asp Leu Ser Pro
        195                 200                 205             
Gln Glu Phe Ala Tyr Thr Pro Tyr Lys Asn Gly Ser Gln Ala Glu His
    210                 215                 220                 
Ile Glu Gln Ile Leu Thr Val Ser Pro Glu Thr Arg Lys Leu Lys Val
225                 230                 235                 240 
Glu Leu Phe Phe Glu Asn Ser Val Gly Gln Ala Trp Leu Asp Asn Ile
                245                 250                 255     
Ser Leu Val Glu Tyr Val Glu Lys Thr Pro Glu Thr Pro Glu Gln Ser
            260                 265                 270         
Pro Glu Leu Val Gln Pro Glu Thr Gly Gln Ile Ser Leu Ala Ser Asn
        275                 280                 285             
Lys Val Tyr Leu Pro Val Arg Pro Asp Leu Thr Tyr Arg Ile Ala Asp
    290                 295                 300                 
Ala Ala Val Ala Thr Val Glu Lys Asn Met Ile Arg Pro Leu Ala Ala
305                 310                 315                 320 
Gly Lys Thr Gln Val Asp Val Tyr Asp Lys Asp Thr Lys Leu Ser Ser
                325                 330                 335     
Phe Glu Leu Ile Val Thr Glu His Gln Ala Thr Val Phe Asp Thr Leu
            340                 345                 350         
Arg Asn Asn Trp Glu Asp Ile Ser Leu Ala Asn Lys Arg Tyr Gln Ser
        355                 360                 365             
Asn Asp Ala Gln Met Lys Ala Phe Leu Gly Arg Leu Asp Ala Gly Val
    370                 375                 380                 
Ala Ser Ser Leu Glu Lys Trp Val Glu Pro Thr Glu Gln Ser Lys Thr
385                 390                 395                 400 
Ile Phe Asn Asp Ile Asp Phe Ser Lys Ser Ser His Leu Thr Thr Val
                405                 410                 415     
Tyr Arg Arg Leu Glu Gln Met Ala Gln Val Val Glu Asn Pro Asp Ser
            420                 425                 430         
Ala Tyr Tyr His Asp Arg Ser Leu Ile Asp Leu Val Arg Lys Gly Met

        435                 440                 445             
Asn Trp Leu Tyr Ala Asn Val Tyr Asn Glu Asn Lys Ser Ile Asp Gly
    450                 455                 460                 
Asn Trp Trp Asp Tyr Glu Ile Gly Thr Ser Arg Ala Val Val Asn Thr
465                 470                 475                 480 
Leu Ile Tyr Met His Pro Tyr Phe Ser Gln Glu Glu Ile Leu Thr Tyr
                485                 490                 495     
Thr Lys Pro Ile Ser Lys Phe Val Pro Asp Pro Thr Thr Ile Arg Lys
            500                 505                 510         
Thr Leu Thr Asn Pro Val Pro Ala Val Gly Gly Asn Gln Thr Asp Leu
        515                 520                 525             
Ser Lys Val Ala Ile Leu Glu Gly Ala Leu Arg Glu Asp Ala Asp Arg
    530                 535                 540                 
Val Arg Ala Gly Ala Gln Gly Leu Thr Thr Ile Met Lys Phe Val Asp
545                 550                 555                 560 
Lys Gly Glu Gly Phe Tyr Arg Asp Gly Ser Phe Ile Asp His Thr Asn
                565                 570                 575     
Val Ala Tyr Thr Gly Ala Tyr Gly Asn Val Leu Ile Glu Gly Phe Ser
            580                 585                 590         
Gln Leu Leu Pro Val Ile Gln Pro Thr Glu Phe Ala Leu Lys Glu Glu
        595                 600                 605             
Gln Thr Asn Ile Leu Tyr Glu Trp Ile Glu Lys Ala Phe Met Pro Ile
    610                 615                 620                 
Leu Val Arg Gly Glu Leu Met Asp Met Thr Arg Gly Arg Ser Ile Ser
625                 630                 635                 640 
Arg Ala Thr Gly Glu Ser His Val Gln Ala Met Glu Ile Leu Arg Ser
                645                 650                 655     
Leu Val Arg Ile Ala Glu Ser Ala Gln Pro Glu Gln Lys Thr Lys Leu
            660                 665                 670         
Leu Ser Phe Val Lys Ala Gln Leu Thr Ser Asp Thr Phe Tyr Asp Ser
        675                 680                 685             
Tyr Arg Ser Leu Lys Ser Tyr Lys Asp Ile Asp Leu Val Asn Lys Leu
    690                 695                 700                 
Leu Ala Asp Asn Gln Ile Pro Ala Glu Val Asp Lys Asp Tyr Ile Ala
705                 710                 715                 720 
Ala Phe Asn Asn Met Asp Lys Phe Val Tyr Arg Ser Ala Gln Glu Gly
                725                 730                 735     
Phe Thr Phe Ala Leu Ser Met Tyr Ser Ser Arg Thr Gln Asn Tyr Glu
            740                 745                 750         
Asp Met Asn Asn Glu Asn Arg Lys Gly Trp Tyr Thr Ala Asp Gly Met
        755                 760                 765             
Val Tyr Leu Tyr Asn Asp Asp Leu Ser His Tyr Ser Asn His Tyr Trp
    770                 775                 780                 
Ala Thr Val Asp Pro Tyr Arg Leu Pro Gly Thr Thr Thr Thr Lys Asp
785                 790                 795                 800 
Lys Arg Glu Asp Gly Ser Gly Glu Val Thr Leu Ala Ser Asp Phe Val
                805                 810                 815     
Gly Ala Ser Gln Leu Gly Asn Arg Leu Ala Thr Ile Ala Met Asp Phe
            820                 825                 830         
Asn Asn Trp Asn Asn Ser Leu Thr Ala Arg Lys Ala Trp Ile Val Leu
        835                 840                 845             
Gly Asn Lys Ile Val Phe Leu Gly Thr Asp Ile Gln His Gln Ser Ala
    850                 855                 860                 
Gln Gly Ala Glu Thr Thr Ile Glu Asn Arg Lys Leu Leu Thr Gly Glu
865                 870                 875                 880 
Lys Tyr Ser Tyr Tyr Ile Asn Gly Gln Pro Val Asp Leu Ser Lys Glu
                885                 890                 895     
Val Val Thr Asp Lys Thr Gln Ser Phe Tyr Met Thr Asn Gly Lys Asp
            900                 905                 910         
Asn Gln Ser Ile Gly Tyr Val Phe Leu Asn Gln Leu Pro Thr His Ala
        915                 920                 925             
Lys Leu Asp Gln Arg Thr Gly Lys Trp Ser Asp Ile Asn Tyr Asn Gln
    930                 935                 940                 
Ser Lys Glu Glu Val Ser Asn Ser Phe Val Ser Leu Trp His Glu His
945                 950                 955                 960 
Ala Gln Thr Ser Ser Asn Tyr Ala Tyr Val Leu Val Pro Asn Gln Ser
                965                 970                 975     
Met Glu Lys Val Asn Gln Ala Ala Ala Ser Val Lys Leu Leu His Gln
            980                 985                 990         
Asp Arg Asp Leu Gln Val Val Tyr Asp Gln Glu Gln Asn Val Trp Gly
        995                 1000                1005            
Val Val Lys Tyr Thr Asp Thr Ala Tyr Lys Leu Thr Asp Asp Ile Thr
    1010                1015                1020                
Leu Thr Asp Ala Gly Leu Tyr Thr Ile Gln Lys Val Glu Gly Gly Tyr
1025                1030                1035               1040 
Arg Ile Ala Phe Tyr Asn Pro Ser Thr Arg Thr Val Lys Asn Gly Ile
                1045                1050                1055    
Glu Leu Thr Lys Ala Gly Ser Ser Leu Thr Val Glu Met Glu Pro Thr
            1060                1065                1070        
Ala Ala Tyr Pro Ser Thr Val Trp Lys Val Thr Met Pro Glu Gly Ser
        1075                1080                1085            
Asp Lys Gln Thr Gly Ser Val Glu Lys Thr Glu Lys Glu Glu Lys Gln
    1090                1095                1100                
Leu Lys Glu Asn Gln Pro Ser Ser Glu Val Lys Gln Val Val His His
1105                1110                1115               1120 
Ala Ala Glu Lys Thr Lys Pro Ser Lys Pro Arg Leu Pro Gln Thr Gly
                1125                1130                1135    
Glu Glu Ala Ser Leu Gly Leu Gly Phe Leu Gly Leu Leu Thr Leu Gly
            1140                1145                1150        
Ala Val Val Asp Phe Lys Cys Arg Arg Ser His Ser
        1155                1160                


<210> 303
<211> 1164
<212> PRT
<213> Streptococcus suis

<220> 
<223> hyaluronan lyase

<400> 303
Met Gly Phe Phe Ile Ser Gln Ser Lys Gln His Tyr Gly Ile Arg Lys
 1               5                  10                  15      
Tyr Lys Val Gly Val Cys Ser Ala Leu Ile Ala Leu Ser Ile Leu Gly
            20                  25                  30          
Thr Arg Val Ala Ala Asn Gln Leu Pro Ser Thr Glu Thr Ala Ser Pro
        35                  40                  45              
Gln Ser Ser Gln Leu Val Glu Thr Thr Pro Glu Thr Thr Glu Ala Val
    50                  55                  60                  
Met Thr Ser Glu Val Ser Ser Glu Val Ser Pro Val Thr Ser Thr Glu
65                  70                  75                  80  
Thr Gln Pro Ser Ser Thr Thr Ala Glu Thr Leu Ala Ser Pro Gln Ala
                85                  90                  95      
Val Gln Ala Thr Lys Glu Glu Lys Asn Leu Val Ala Asn Gly Glu Phe
            100                 105                 110         
Ile Ser Thr Thr Ala Pro Ser Gly Asn Trp Lys Glu Leu Ala Ala Thr
        115                 120                 125             
Asn Trp Glu Thr Trp Ile Pro Ala Asn Val Lys Lys Glu Asn Gly Gln
    130                 135                 140                 
Val Arg Ile Asp Glu Gly Arg Leu His Ile Ser Ser Thr Ala Ser Tyr
145                 150                 155                 160 
Arg Val Ala Val His Gln Thr Val Asp Val Asp Pro Asn Lys Arg Tyr
                165                 170                 175     
Leu Phe Ser Tyr Asp Val Glu Thr Lys Asp Leu Lys Gly Ser Gly Val
            180                 185                 190         
Arg Val Arg Leu Arg Ser Leu Thr Ala Glu Gly Lys Asp Leu Ser Pro
        195                 200                 205             
Gln Glu Phe Ala Tyr Thr Pro Tyr Lys Asn Gly Ser Gln Ala Glu His
    210                 215                 220                 
Ile Glu Gln Ile Leu Thr Val Ser Pro Glu Thr Arg Lys Leu Lys Val
225                 230                 235                 240 
Glu Leu Phe Phe Glu Asn Ser Val Gly Gln Ala Trp Leu Asp Asn Ile
                245                 250                 255     
Ser Leu Val Glu Tyr Val Glu Lys Thr Pro Glu Thr Pro Glu Gln Ser
            260                 265                 270         
Pro Glu Leu Val Gln Pro Glu Thr Gly Gln Ile Ser Leu Ala Ser Asn
        275                 280                 285             
Lys Val Tyr Leu Pro Val Arg Pro Asp Leu Thr Tyr Arg Ile Ala Asp
    290                 295                 300                 
Ala Ala Val Ala Thr Val Glu Lys Asn Met Ile Arg Pro Leu Ala Ala
305                 310                 315                 320 
Gly Lys Thr Gln Val Asp Val Tyr Asp Lys Asp Thr Lys Leu Ser Ser
                325                 330                 335     
Phe Glu Leu Ile Val Thr Glu His Gln Ala Thr Val Phe Asp Thr Leu
            340                 345                 350         
Arg Asn Asn Trp Glu Asp Ile Ser Leu Ala Asn Lys Arg Tyr Gln Ser
        355                 360                 365             
Asn Asp Ala Gln Met Lys Ala Phe Leu Gly Arg Leu Asp Ala Gly Val
    370                 375                 380                 
Ala Ser Ser Leu Glu Lys Trp Val Glu Pro Thr Glu Gln Ser Lys Thr
385                 390                 395                 400 
Ile Phe Asn Asp Ile Asp Phe Ser Lys Ser Ser His Leu Thr Thr Val
                405                 410                 415     
Tyr Arg Arg Leu Glu Gln Met Ala Gln Val Val Glu Asn Pro Asp Ser
            420                 425                 430         
Ala Tyr Tyr His Asp Arg Ser Leu Ile Asp Leu Val Arg Lys Gly Met
        435                 440                 445             
Asn Trp Leu Tyr Thr Asn Val Tyr Asn Glu Asn Lys Ser Ile Asp Gly
    450                 455                 460                 
Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro Arg Ala Val Val Asn Thr
465                 470                 475                 480 
Leu Ile Tyr Met His Pro Tyr Phe Ser Gln Glu Glu Ile Leu Thr Tyr
                485                 490                 495     
Thr Lys Pro Ile Ser Lys Phe Val Pro Asp Pro Thr Thr Ile Arg Lys
            500                 505                 510         
Thr Leu Thr Asn Pro Val Pro Ala Val Gly Gly Asn Gln Thr Asp Leu
        515                 520                 525             
Ser Lys Val Ala Ile Leu Glu Gly Ala Leu Arg Glu Asp Ala Asp Arg
    530                 535                 540                 
Val Arg Ala Gly Ala Gln Gly Leu Thr Thr Ile Met Lys Phe Val Asp
545                 550                 555                 560 
Lys Gly Glu Gly Phe Tyr Arg Asp Gly Ser Phe Ile Asp His Thr Asn
                565                 570                 575     
Val Ala Tyr Thr Gly Ala Tyr Gly Asn Val Leu Ile Glu Gly Phe Ser
            580                 585                 590         
Gln Leu Leu Pro Val Ile Gln Pro Thr Glu Phe Ala Leu Lys Glu Glu
        595                 600                 605             
Gln Thr Asn Ile Leu Tyr Glu Trp Ile Glu Lys Ala Phe Met Pro Ile
    610                 615                 620                 
Leu Val Arg Gly Glu Leu Met Asp Met Thr Arg Gly Arg Ser Ile Ser
625                 630                 635                 640 
Arg Ala Thr Gly Glu Ser His Val Gln Ala Met Glu Ile Leu Arg Ser
                645                 650                 655     
Leu Val Arg Ile Ala Glu Ser Ala Gln Pro Glu Gln Lys Thr Lys Leu
            660                 665                 670         
Leu Ser Phe Val Lys Ala Gln Leu Thr Ser Asp Thr Phe Tyr Asp Ser
        675                 680                 685             
Tyr Arg Ser Leu Lys Ser Tyr Lys Asp Ile Asp Leu Val Asn Lys Leu
    690                 695                 700                 
Leu Ala Asp Asn Gln Ile Pro Ala Glu Val Asp Lys Asp Tyr Ile Ala
705                 710                 715                 720 
Ala Phe Asn Asn Met Asp Lys Phe Val Tyr Arg Ser Ala Gln Glu Gly
                725                 730                 735     
Phe Thr Phe Ala Leu Ser Met Tyr Ser Ser Arg Thr Gln Asn Tyr Glu
            740                 745                 750         
Asp Met Asn Asn Glu Asn Arg Lys Gly Trp Tyr Thr Ala Asp Gly Met
        755                 760                 765             
Val Tyr Leu Tyr Asn Asp Asp Leu Ser His Tyr Ser Asn His Tyr Trp
    770                 775                 780                 
Ala Thr Val Asp Pro Tyr Arg Leu Pro Gly Thr Thr Thr Thr Lys Asp
785                 790                 795                 800 
Lys Arg Glu Asp Gly Ser Gly Glu Val Thr Leu Ala Ser Asp Phe Val
                805                 810                 815     
Gly Ala Ser Gln Leu Gly Asn Arg Leu Ala Thr Ile Ala Met Asp Phe
            820                 825                 830         
Asn Asn Trp Asn Asn Ser Leu Thr Ala Arg Lys Ala Trp Ile Val Leu
        835                 840                 845             
Gly Asn Lys Ile Val Phe Leu Gly Thr Asp Ile Gln His Gln Ser Ala
    850                 855                 860                 
Gln Gly Ala Glu Thr Thr Ile Glu Asn Arg Lys Leu Leu Thr Gly Glu
865                 870                 875                 880 
Lys Tyr Ser Tyr Tyr Ile Asn Gly Gln Pro Val Asp Leu Ser Lys Glu
                885                 890                 895     
Val Val Thr Asp Lys Thr Gln Ser Phe Tyr Met Thr Asn Gly Lys Asp
            900                 905                 910         
Asn Gln Ser Ile Gly Tyr Val Phe Leu Asn Gln Leu Pro Thr His Ala
        915                 920                 925             
Lys Leu Asp Gln Arg Thr Gly Lys Trp Ser Asp Ile Asn Tyr Asn Gln
    930                 935                 940                 
Ser Lys Glu Glu Val Ser Asn Ser Phe Val Ser Leu Trp His Glu His
945                 950                 955                 960 
Ala Gln Thr Ser Ser Asn Tyr Ala Tyr Val Leu Val Pro Asn Gln Ser
                965                 970                 975     
Met Glu Lys Val Asn Gln Ala Ala Ala Ser Val Lys Leu Leu His Gln
            980                 985                 990         
Asp Arg Asp Leu Gln Val Val Tyr Asp Gln Glu Gln Asn Val Trp Gly
        995                 1000                1005            
Val Val Lys Tyr Thr Asp Thr Ala Tyr Lys Leu Thr Asp Asp Ile Thr
    1010                1015                1020                
Leu Thr Asp Ala Gly Leu Tyr Thr Ile Gln Lys Val Glu Gly Gly Tyr
1025                1030                1035               1040 
Arg Ile Ala Phe Tyr Asn Pro Ser Thr Arg Thr Val Lys Asn Gly Ile
                1045                1050                1055    
Glu Leu Thr Lys Ala Gly Ser Ser Leu Thr Val Glu Met Glu Pro Thr
            1060                1065                1070        
Ala Ala Tyr Pro Ser Thr Val Trp Lys Val Thr Met Pro Glu Gly Ser
        1075                1080                1085            
Asp Lys Gln Thr Gly Ser Val Glu Lys Thr Glu Lys Glu Glu Lys Gln
    1090                1095                1100                
Leu Lys Glu Asn Gln Pro Ser Ser Glu Val Lys Gln Val Val His His
1105                1110                1115               1120 
Ala Ala Glu Lys Thr Lys Pro Ser Lys Pro Arg Leu Pro Gln Thr Gly
                1125                1130                1135    
Glu Glu Ala Ser Leu Gly Leu Gly Phe Leu Gly Leu Leu Thr Leu Gly
            1140                1145                1150        
Ala Val Val Asp Phe Lys Cys Arg Arg Ser His Ser
        1155                1160                


<210> 304
<211> 802
<212> PRT
<213> Vibrio fischeri (strain ATCC 700601 / ES114)

<220> 
<223> hyaluronan lyase

<400> 304
Met Tyr Met Ile Lys Lys His Arg Leu Asn Thr Ile Ala Leu Ser Met
 1               5                  10                  15      
Leu Phe Leu Phe Thr Gly Asn Ala Tyr Ala Ala Lys Asn Thr Gln Thr
            20                  25                  30          
Pro Gln Tyr Leu Pro Ser Asp Phe Glu Gln Val Arg Glu Asn Trp Ala
        35                  40                  45              
Glu Asn Tyr Leu Gly Asp Pro Ala Ile Thr Phe Asp Gln Thr Leu Lys
    50                  55                  60                  
Asn Met Val Thr Ser Thr Asn Ser Ser Ala Gln Lys His Trp Asp Ser
65                  70                  75                  80  
Met Thr Pro Gln Pro Asn Ala Ser Gly Ile Trp Asp Asp Leu Pro Leu
                85                  90                  95      
Ile Asp Lys Asp Thr Thr Leu Gly Pro Asn Ile Arg Asn Ser Tyr Gln
            100                 105                 110         
Arg Leu Phe Thr Met Ala Lys Ala Tyr Arg Leu Arg Asp Gly Asn Leu
        115                 120                 125             
Glu Asn Asn Gln Leu Met Leu Asn Asp Ile Met Thr Ala Met Asn Tyr
    130                 135                 140                 
Ile Asn Gln Asn Phe Tyr Phe Val Asn Gln Leu Glu Tyr Gly Asn Trp
145                 150                 155                 160 
Trp Gln Trp Glu Leu Ala Ile Pro Lys Asp Ile His Asn Ile Leu Val
                165                 170                 175     
Leu Leu Phe Asp Asp Ile Lys Asp Asn Tyr Gln Thr Ile Ile Thr Asn
            180                 185                 190         
His Leu Asn Ala Thr Arg Tyr Phe Thr Pro Asp Pro Thr His Leu Gly
        195                 200                 205             
Val Ser Pro Gly Ala Ala Glu Ser Thr Asn Pro Asn Tyr Arg Glu Ser
    210                 215                 220                 
Thr Gly Gly Asn Arg Thr Asp Asn Ala Gln Val Val Leu Ile Arg Gly
225                 230                 235                 240 
Met Leu Glu Asn Asn Ser Glu Glu Ile Ser Gln Ala Ile Ala Ala Leu
                245                 250                 255     
Pro Ala Val Ile Glu Tyr Val Ser Glu Gly Asp Gly Tyr Tyr Thr Asp
            260                 265                 270         
Gly Ser Phe Leu Gln His Ser Asp Ile Ala Tyr Asn Gly Thr Tyr Gly
        275                 280                 285             
Asn Val Leu Leu Gly Gly Leu Gly Ile Gln Met Asn Ala Val Ala Gly
    290                 295                 300                 
Ser Pro Trp Ser Met Asp Asn Gln Thr Ile Ser Asn Val Tyr Asn Ile
305                 310                 315                 320 
Ile Asn Gln Ser Tyr Glu Pro Leu Leu Tyr Lys Gly Ala Met Met Asp
                325                 330                 335     
Met Val Asn Gly Arg Ser Ile Ser Arg Ser Ala Glu Gln Asn His Asp
            340                 345                 350         
Val Gly Leu Asn Ile Val Asn Ser Met Leu Phe Tyr Thr Asn Gly Pro
        355                 360                 365             
Asp Ser Asp Lys Asn Lys Gln Leu Ser Ser Leu Ile Lys Thr Gln Ile
    370                 375                 380                 
Thr Asp Asp Thr Tyr Gln Asn Phe Phe Asp Lys Ile Tyr Tyr Val Ser
385                 390                 395                 400 
Thr Tyr Gln Ala Ala Gln His Ile Val Asn Asp Pro Thr Val Ser Leu
                405                 410                 415     
Lys Asp Pro Leu Ile Gly Asn Phe Ser Tyr Pro Ser Met Asp Arg Ile
            420                 425                 430         
Val His Arg Arg Thr Asp Trp Ala Phe Ala Leu Ala Met His Ser Tyr
        435                 440                 445             
Arg Ile Gly Asn Tyr Glu Cys Met Asn Gly Glu Asn Leu Lys Gly Trp
    450                 455                 460                 
Phe Thr Gly Asp Gly Met Ile Tyr Leu Tyr Asn Asp Gln Leu Asp His
465                 470                 475                 480 
Tyr Thr Gly Tyr Trp Pro Thr Val Asn Ala Ser Arg Met Pro Gly Thr
                485                 490                 495     
Thr Val Asp Ser Gln Ile Met Ala Asp Cys Ser Gly Glu Arg Val Gly
            500                 505                 510         
Gly Asn Val Asn Thr Asn Met Gln Trp Val Gly Ser Thr Ser Leu Asn
        515                 520                 525             
Asn Tyr Gly Ile Ala Gly Met Gln Phe Tyr Asn Trp Ser Asp Thr Leu
    530                 535                 540                 
Ser Ala Tyr Lys Ser Trp Phe Met Phe Asp Asn Glu Val Val Met Leu
545                 550                 555                 560 
Gly Ser Asn Ile Lys Asp Gln Ser Asn Ala Asn Asn Ile Thr Thr Ile
                565                 570                 575     
Glu Asn Arg Lys Arg Leu Ala Glu Thr Lys Leu Phe Ile Asp Gly Thr
            580                 585                 590         
Glu Gln Ala Ala Leu Pro Tyr Gln Gly Ala Pro Ala Thr Phe Ser Ile
        595                 600                 605             
Arg Asn Lys Thr Leu Ala Asn Ser Asp Leu Ser Tyr Val Met Leu Thr
    610                 615                 620                 
Pro Lys Thr Ile Ser Ile Ser Gln Asn Asp Val Asp Gly Asn Trp Ser
625                 630                 635                 640 
Asp Ile Gly Asn Ser Lys Gly Asp Val Ser Asp Ser Tyr Leu Gln Ala
                645                 650                 655     
Thr Leu Thr Gln Val Asp Gln Ala Asp Tyr Gln Tyr Ala Leu Leu Pro
            660                 665                 670         
Asn Gln Asn Asn Asp Thr Val Gln Asn Tyr Ala Gln His Pro Asp Val
        675                 680                 685             
Thr Val Leu Arg Gln Asp Glu Gln Ala His Ala Val Gln Glu Asn Thr
    690                 695                 700                 
Leu Asn Ile Ile Ala Ala Asn Asn Trp Lys Asn Asn Pro Val Asn Ile
705                 710                 715                 720 
Thr Asp Thr Ile Thr Leu Asn Ser Met Met Gly Phe Met Ile Lys Glu
                725                 730                 735     
Glu Ser Ser Asn Thr Phe Thr Val Ala Val Ser Glu Pro Ile Gln Thr
            740                 745                 750         
Ile Asp Ser Val Asn Phe Thr Phe Asp Lys Gln Gly Ile Val Ile Lys
        755                 760                 765             
Glu Asp Ile Glu Asn Arg Val Val Leu Asn Gly Thr Thr Leu Thr Ile
    770                 775                 780                 
Asn Thr Ser Gly Leu Gln Gly Gln Ser Tyr Ser Phe Gln Val Thr Ile
785                 790                 795                 800 
Gln Asp
        



<210> 305
<211> 517
<212> PRT
<213> Synechococcus sp. (strain RCC307)

<220> 
<223> hyaluronan lyase

<400> 305
Met Gly Ala Pro Ala Ile Pro Lys Val Pro Arg Ser Pro Ser Lys Ser
 1               5                  10                  15      
Glu His Thr Thr Arg Pro Asn Ser Gly Glu Ser Glu Val Val Arg Gln
            20                  25                  30          
Ala Glu Glu Leu Phe Glu Gln Thr Leu Val Asn Val Arg Gly Gln Leu
        35                  40                  45              
Ala Gly Ala Val Ala Ala Leu Glu Ser Ser Val His Asp Ser Glu Leu
    50                  55                  60                  
Asn Tyr Gly Glu Ile Phe Leu Arg Asp Asn Val Pro Val Met Val Tyr
65                  70                  75                  80  
Leu Leu Leu Arg Gly Arg Phe Glu Ile Val Arg His Phe Leu Asp Leu
                85                  90                  95      
Cys Leu Glu Leu Gln Ser Arg Ser Tyr Arg Thr Arg Gly Val Phe Pro
            100                 105                 110         
Thr Ser Phe Val Glu Glu Asp Asp Lys Ile Leu Ala Asp Tyr Gly Gln
        115                 120                 125             
Arg Ser Ile Gly Arg Ile Thr Ser Val Asp Ala Ser Leu Trp Trp Pro
    130                 135                 140                 
Val Leu Cys Trp Met Tyr Val Arg Ala Ser Gly Asp Thr Ser Tyr Gly
145                 150                 155                 160 
Thr Ser Pro Lys Val Gln Arg Ala Val Gln Leu Leu Leu Asp Leu Val
                165                 170                 175     
Leu Gln Pro Ser Phe Tyr Glu Pro Pro Val Leu Phe Val Pro Asp Cys
            180                 185                 190         
Ala Phe Met Ile Asp Arg Pro Met Asp Val Trp Gly Ala Pro Leu Glu
        195                 200                 205             
Val Glu Val Leu Leu Phe Gly Cys Leu Lys Ser Cys Cys Gln Leu Met
    210                 215                 220                 
Ser Leu Val Glu Gly Gly Gly His Gly Gly Pro Leu Ile Gln Gln Arg
225                 230                 235                 240 
Leu Glu Leu Thr Arg Thr Trp Met Arg Asp Leu Arg Val Tyr Leu Leu
                245                 250                 255     
Asn His Tyr Trp Val Thr Ser Lys Thr Met Gln Val Leu Arg Arg Arg
            260                 265                 270         
Pro Thr Glu Gln Tyr Gly Asp Tyr Gln Ser Arg Asn Glu Phe Asn Val
        275                 280                 285             
Gln Pro Glu Val Ile Pro His Trp Leu Gln Glu Trp Leu Asp Asp Arg
    290                 295                 300                 
Gly Gly Tyr Leu Ile Gly Asn Met Arg Thr Gly Arg Pro Asp Phe Arg
305                 310                 315                 320 
Phe Tyr Ser Leu Gly Asn Ala Leu Gly Ser Leu Phe Gly Leu Leu Thr
                325                 330                 335     
Gly Pro Gln Gln Leu Ala Leu Phe Arg Leu Val Ile His Asn Arg Gln
            340                 345                 350         
His Leu Met Ala Glu Met Pro Met Arg Ile Cys His Pro Pro Met Asp
        355                 360                 365             
Gln Asp Glu Trp Ile Thr Asn Thr Gly Met Asp Pro Lys Asn Trp Pro
    370                 375                 380                 
Trp Ser Tyr His Asn Gly Gly His Trp Pro Ser Leu Leu Trp Pro Met
385                 390                 395                 400 
Ala Ala Ala Val Leu Met His Gln Arg Leu Tyr Pro Asn Asp Asp Leu
                405                 410                 415     
Leu Leu Leu Gly Gln Thr Arg Thr Met Leu Glu Glu Cys Tyr Trp Gln
            420                 425                 430         
Gln Leu Asn Gln Leu Pro Arg Gln Gln Trp Ala Glu Tyr Phe Asp Gly
        435                 440                 445             
Pro Thr Gly Thr Trp Val Gly Gln Gln Ala Arg Ile Asn Gln Thr Trp
    450                 455                 460                 
Thr Ile Val Gly Phe Leu Leu Leu His His Leu Met Arg Lys Ala Pro
465                 470                 475                 480 
Gln Asp Val Lys Leu Leu Asp Leu Asp Asp Val Gly Pro Leu Arg Leu
                485                 490                 495     
Ser Phe Gln Asp Gln His Glu Lys Ser Ser Thr Asp Glu Arg Lys Ser
            500                 505                 510         
Phe Leu Lys Asn Tyr
        515         


<210> 306
<211> 1021
<212> PRT
<213> Proteus vulgaris

<220> 
<223> chondroitin-sulfate-ABC endolyase

<400> 306
Met Pro Ile Phe Arg Phe Thr Ala Leu Ala Met Thr Leu Gly Leu Leu
 1               5                  10                  15      
Ser Ala Pro Tyr Asn Ala Met Ala Ala Thr Ser Asn Pro Ala Phe Asp
            20                  25                  30          
Pro Lys Asn Leu Met Gln Ser Glu Ile Tyr His Phe Ala Gln Asn Asn
        35                  40                  45              
Pro Leu Ala Asp Phe Ser Ser Asp Lys Asn Ser Ile Leu Thr Leu Ser
    50                  55                  60                  
Asp Lys Arg Ser Ile Met Gly Asn Gln Ser Leu Leu Trp Lys Trp Lys
65                  70                  75                  80  
Gly Gly Ser Ser Phe Thr Leu His Lys Lys Leu Ile Val Pro Thr Asp
                85                  90                  95      
Lys Glu Ala Ser Lys Ala Trp Gly Arg Ser Ser Thr Pro Val Phe Ser
            100                 105                 110         
Phe Trp Leu Tyr Asn Glu Lys Pro Ile Asp Gly Tyr Leu Thr Ile Asp
        115                 120                 125             
Phe Gly Glu Lys Leu Ile Ser Thr Ser Glu Ala Gln Ala Gly Phe Lys
    130                 135                 140                 
Val Lys Leu Asp Phe Thr Gly Trp Arg Ala Val Gly Val Ser Leu Asn
145                 150                 155                 160 
Asn Asp Leu Glu Asn Arg Glu Met Thr Leu Asn Ala Thr Asn Thr Ser
                165                 170                 175     
Ser Asp Gly Thr Gln Asp Ser Ile Gly Arg Ser Leu Gly Ala Lys Val
            180                 185                 190         
Asp Ser Ile Arg Phe Lys Ala Pro Ser Asn Val Ser Gln Gly Glu Ile
        195                 200                 205             
Tyr Ile Asp Arg Ile Met Phe Ser Val Asp Asp Ala Arg Tyr Gln Trp
    210                 215                 220                 
Ser Asp Tyr Gln Val Lys Thr Arg Leu Ser Glu Pro Glu Ile Gln Phe
225                 230                 235                 240 
His Asn Val Lys Pro Gln Leu Pro Val Thr Pro Glu Asn Leu Ala Ala
                245                 250                 255     
Ile Asp Leu Ile Arg Gln Arg Leu Ile Asn Glu Phe Val Gly Gly Glu
            260                 265                 270         
Lys Glu Thr Asn Leu Ala Leu Glu Glu Asn Ile Ser Lys Leu Lys Ser
        275                 280                 285             
Asp Phe Asp Ala Leu Asn Ile His Thr Leu Ala Asn Gly Gly Thr Gln
    290                 295                 300                 
Gly Arg His Leu Ile Thr Asp Lys Gln Ile Ile Ile Tyr Gln Pro Glu
305                 310                 315                 320 
Asn Leu Asn Ser Gln Asp Lys Gln Leu Phe Asp Asn Tyr Val Ile Leu
                325                 330                 335     
Gly Asn Tyr Thr Thr Leu Met Phe Asn Ile Ser Arg Ala Tyr Val Leu
            340                 345                 350         
Glu Lys Asp Pro Thr Gln Lys Ala Gln Leu Lys Gln Met Tyr Leu Leu
        355                 360                 365             
Met Thr Lys His Leu Leu Asp Gln Gly Phe Val Lys Gly Ser Ala Leu
    370                 375                 380                 
Val Thr Thr His His Trp Gly Tyr Ser Ser Arg Trp Trp Tyr Ile Ser
385                 390                 395                 400 
Thr Leu Leu Met Ser Asp Ala Leu Lys Glu Ala Asn Leu Gln Thr Gln
                405                 410                 415     
Val Tyr Asp Ser Leu Leu Trp Tyr Ser Arg Glu Phe Lys Ser Ser Phe
            420                 425                 430         
Asp Met Lys Val Ser Ala Asp Ser Ser Asp Leu Asp Tyr Phe Asn Thr
        435                 440                 445             
Leu Ser Arg Gln His Leu Ala Leu Leu Leu Leu Glu Pro Asp Asp Gln
    450                 455                 460                 
Lys Arg Ile Asn Leu Val Asn Thr Phe Ser His Tyr Ile Thr Gly Ala
465                 470                 475                 480 
Leu Thr Gln Val Pro Pro Gly Gly Lys Asp Gly Leu Arg Pro Asp Gly
                485                 490                 495     
Thr Ala Trp Arg His Glu Gly Asn Tyr Pro Gly Tyr Ser Phe Pro Ala
            500                 505                 510         
Phe Lys Asn Ala Ser Gln Leu Ile Tyr Leu Leu Arg Asp Thr Pro Phe
        515                 520                 525             
Ser Val Gly Glu Ser Gly Trp Asn Asn Leu Lys Lys Ala Met Val Ser
    530                 535                 540                 
Ala Trp Ile Tyr Ser Asn Pro Glu Val Gly Leu Pro Leu Ala Gly Arg
545                 550                 555                 560 
His Pro Phe Asn Ser Pro Ser Leu Lys Ser Val Ala Gln Gly Tyr Tyr
                565                 570                 575     
Trp Leu Ala Met Ser Ala Lys Ser Ser Pro Asp Lys Thr Leu Ala Ser
            580                 585                 590         
Ile Tyr Leu Ala Ile Ser Asp Lys Thr Gln Asn Glu Ser Thr Ala Ile
        595                 600                 605             
Phe Gly Glu Thr Ile Thr Pro Ala Ser Leu Pro Gln Gly Phe Tyr Ala
    610                 615                 620                 
Phe Asn Gly Gly Ala Phe Gly Ile His Arg Trp Gln Asp Lys Met Val
625                 630                 635                 640 
Thr Leu Lys Ala Tyr Asn Thr Asn Val Trp Ser Ser Glu Ile Tyr Asn
                645                 650                 655     
Lys Asp Asn Arg Tyr Gly Arg Tyr Gln Ser His Gly Val Ala Gln Ile
            660                 665                 670         

Val Ser Asn Gly Ser Gln Leu Ser Gln Gly Tyr Gln Gln Glu Gly Trp
        675                 680                 685             
Asp Trp Asn Arg Met Glu Gly Ala Thr Thr Ile His Leu Pro Leu Lys
    690                 695                 700                 
Asp Leu Asp Ser Pro Lys Pro His Thr Leu Met Gln Arg Gly Glu Arg
705                 710                 715                 720 
Gly Phe Ser Gly Thr Ser Ser Leu Glu Gly Gln Tyr Gly Met Met Ala
                725                 730                 735     
Phe Asn Leu Ile Tyr Pro Ala Asn Leu Glu Arg Phe Asp Pro Asn Phe
            740                 745                 750         
Thr Ala Lys Lys Ser Val Leu Ala Ala Asp Asn His Leu Ile Phe Ile
        755                 760                 765             
Gly Ser Asn Ile Asn Ser Ser Asp Lys Asn Lys Asn Val Glu Thr Thr
    770                 775                 780                 
Leu Phe Gln His Ala Ile Thr Pro Thr Leu Asn Thr Leu Trp Ile Asn
785                 790                 795                 800 
Gly Gln Lys Ile Glu Asn Met Pro Tyr Gln Thr Thr Leu Gln Gln Gly
                805                 810                 815     
Asp Trp Leu Ile Asp Ser Asn Gly Asn Gly Tyr Leu Ile Thr Gln Ala
            820                 825                 830         
Glu Lys Val Asn Val Ser Arg Gln His Gln Val Ser Ala Glu Asn Lys
        835                 840                 845             
Asn Arg Gln Pro Thr Glu Gly Asn Phe Ser Ser Ala Trp Ile Asp His
    850                 855                 860                 
Ser Thr Arg Pro Lys Asp Ala Ser Tyr Glu Tyr Met Val Phe Leu Asp
865                 870                 875                 880 
Ala Thr Pro Glu Lys Met Gly Glu Met Ala Gln Lys Phe Arg Glu Asn
                885                 890                 895     
Asn Gly Leu Tyr Gln Val Leu Arg Lys Asp Lys Asp Val His Ile Ile
            900                 905                 910         
Leu Asp Lys Leu Ser Asn Val Thr Gly Tyr Ala Phe Tyr Gln Pro Ala
        915                 920                 925             
Ser Ile Glu Asp Lys Trp Ile Lys Lys Val Asn Lys Pro Ala Ile Val
    930                 935                 940                 
Met Thr His Arg Gln Lys Asp Thr Leu Ile Val Ser Ala Val Thr Pro
945                 950                 955                 960 
Asp Leu Asn Met Thr Arg Gln Lys Ala Ala Thr Pro Val Thr Ile Asn
                965                 970                 975     
Val Thr Ile Asn Gly Lys Trp Gln Ser Ala Asp Lys Asn Ser Glu Val
            980                 985                 990         
Lys Tyr Gln Val Ser Gly Asp Asn Thr Glu Leu Thr Phe Thr Ser Tyr
        995                 1000                1005            
Phe Gly Ile Pro Gln Glu Ile Lys Leu Ser Pro Leu Pro
    1010                1015                1020    


<210> 307
<211> 700
<212> PRT
<213> Pedobacter heparinus

<220> 
<223> chondroitin AC lyase 

<400> 307
Met Lys Lys Leu Phe Val Thr Cys Ile Val Phe Phe Ser Ile Leu Ser
 1               5                  10                  15      
Pro Ala Leu Leu Ile Ala Gln Gln Thr Gly Thr Ala Glu Leu Ile Met
            20                  25                  30          
Lys Arg Val Met Leu Asp Leu Lys Lys Pro Leu Arg Asn Met Asp Lys
        35                  40                  45              
Val Ala Glu Lys Asn Leu Asn Thr Leu Gln Pro Asp Gly Ser Trp Lys
    50                  55                  60                  
Asp Val Pro Tyr Lys Asp Asp Ala Met Thr Asn Trp Leu Pro Asn Asn
65                  70                  75                  80  
His Leu Leu Gln Leu Glu Thr Ile Ile Gln Ala Tyr Ile Glu Lys Asp
                85                  90                  95      
Ser His Tyr Tyr Gly Asp Asp Lys Val Phe Asp Gln Ile Ser Lys Ala
            100                 105                 110         
Phe Lys Tyr Trp Tyr Asp Ser Asp Pro Lys Ser Arg Asn Trp Trp His
        115                 120                 125             
Asn Glu Ile Ala Thr Pro Gln Ala Leu Gly Glu Met Leu Ile Leu Met
    130                 135                 140                 
Arg Tyr Gly Lys Lys Pro Leu Asp Glu Ala Leu Val His Lys Leu Thr
145                 150                 155                 160 
Glu Arg Met Lys Arg Gly Glu Pro Glu Lys Lys Thr Gly Ala Asn Lys
                165                 170                 175     
Thr Asp Ile Ala Leu His Tyr Phe Tyr Arg Ala Leu Leu Thr Ser Asp
            180                 185                 190         
Glu Ala Leu Leu Ser Phe Ala Val Lys Glu Leu Phe Tyr Pro Val Gln
        195                 200                 205             
Phe Val His Tyr Glu Glu Gly Leu Gln Tyr Asp Tyr Ser Tyr Leu Gln
    210                 215                 220                 
His Gly Pro Gln Leu Gln Ile Ser Ser Tyr Gly Ala Val Phe Ile Thr
225                 230                 235                 240 
Gly Val Leu Lys Leu Ala Asn Tyr Val Arg Asp Thr Pro Tyr Ala Leu
                245                 250                 255     
Ser Thr Glu Lys Leu Ala Ile Phe Ser Lys Tyr Tyr Arg Asp Ser Tyr
            260                 265                 270         
Leu Lys Ala Ile Arg Gly Ser Tyr Met Asp Phe Asn Val Glu Gly Arg
        275                 280                 285             
Gly Val Ser Arg Pro Asp Ile Leu Asn Lys Lys Ala Glu Lys Lys Arg
    290                 295                 300                 
Leu Leu Val Ala Lys Met Ile Asp Leu Lys His Thr Glu Glu Trp Ala
305                 310                 315                 320 
Asp Ala Ile Ala Arg Thr Asp Ser Thr Val Ala Ala Gly Tyr Lys Ile
                325                 330                 335     
Glu Pro Tyr His His Gln Phe Trp Asn Gly Asp Tyr Val Gln His Leu
            340                 345                 350         
Arg Pro Ala Tyr Ser Phe Asn Val Arg Met Val Ser Lys Arg Thr Arg
        355                 360                 365             
Arg Ser Glu Ser Gly Asn Lys Glu Asn Leu Leu Gly Arg Tyr Leu Ser
    370                 375                 380                 
Asp Gly Ala Thr Asn Ile Gln Leu Arg Gly Pro Glu Tyr Tyr Asn Ile
385                 390                 395                 400 
Met Pro Val Trp Glu Trp Asp Lys Ile Pro Gly Ile Thr Ser Arg Asp
                405                 410                 415     
Tyr Leu Thr Asp Arg Pro Leu Thr Lys Leu Trp Gly Glu Gln Gly Ser
            420                 425                 430         
Asn Asp Phe Ala Gly Gly Val Ser Asp Gly Val Tyr Gly Ala Ser Ala
        435                 440                 445             
Tyr Ala Leu Asp Tyr Asp Ser Leu Gln Ala Lys Lys Ala Trp Phe Phe
    450                 455                 460                 
Phe Asp Lys Glu Ile Val Cys Leu Gly Ala Gly Ile Asn Ser Asn Ala
465                 470                 475                 480 
Pro Glu Asn Ile Thr Thr Thr Leu Asn Gln Ser Trp Leu Asn Gly Pro
                485                 490                 495     
Val Ile Ser Thr Ala Gly Lys Thr Gly Arg Gly Lys Ile Thr Thr Phe
            500                 505                 510         
Lys Ala Gln Gly Gln Phe Trp Leu Leu His Asp Ala Ile Gly Tyr Tyr
        515                 520                 525             
Phe Pro Glu Gly Ala Asn Leu Ser Leu Ser Thr Gln Ser Gln Lys Gly
    530                 535                 540                 
Asn Trp Phe His Ile Asn Asn Ser His Ser Lys Asp Glu Val Ser Gly
545                 550                 555                 560 
Asp Val Phe Lys Leu Trp Ile Asn His Gly Ala Arg Pro Glu Asn Ala
                565                 570                 575     
Gln Tyr Ala Tyr Ile Val Leu Pro Gly Ile Asn Lys Pro Glu Glu Ile
            580                 585                 590         
Lys Lys Tyr Asn Gly Thr Ala Pro Lys Val Leu Ala Asn Thr Asn Gln
        595                 600                 605             
Leu Gln Ala Val Tyr His Gln Gln Leu Asp Met Val Gln Ala Ile Phe
    610                 615                 620                 
Tyr Thr Ala Gly Lys Leu Ser Val Ala Gly Ile Glu Ile Glu Thr Asp
625                 630                 635                 640 
Lys Pro Cys Ala Val Leu Ile Lys His Ile Asn Gly Lys Gln Val Ile
                645                 650                 655     
Trp Ala Ala Asp Pro Leu Gln Lys Glu Lys Thr Ala Val Leu Ser Ile
            660                 665                 670         
Arg Asp Leu Lys Thr Gly Lys Thr Asn Arg Val Lys Ile Asp Phe Pro
        675                 680                 685             
Gln Gln Glu Phe Ala Gly Ala Thr Val Glu Leu Lys
    690                 695                 700 


<210> 308
<211> 844
<212> PRT
<213> Victivallis vadensis ATCC BAA-548

<220> 
<223> chondroitin AC lyase 
      
<400> 308
Met His Arg Lys Ile Val Phe Pro Leu Phe Val Leu Leu Phe Thr Ala
 1               5                  10                  15      
Phe Ala Ala Phe Ala Ala Ser Gln Pro Gln Trp Lys Trp Arg Gln Ser
            20                  25                  30          
Lys Tyr Cys Arg Ile Thr Glu His Ala Gly Lys Lys Leu Leu Thr Val
        35                  40                  45              
Ala Ile Pro Ala Asp Ala Pro Glu Ile Ser Arg Arg Asn Thr Ala Asp
    50                  55                  60                  
Thr Pro Val Gly Leu Thr Cys Phe Glu Gly Gln Pro Ile Glu Phe Ser
65                  70                  75                  80  
Ile Arg Leu Arg Asn Ser Gly Ile Ser Arg Pro Asp Asn Leu His Asn
                85                  90                  95      
Gly Ile Lys Phe Gln Leu Tyr Phe Arg Asp Gly Asn Gly Thr Glu Arg
            100                 105                 110         
Trp Thr Gln Ala Glu Ile Pro His Glu Pro Phe Pro Trp Arg Arg Phe
        115                 120                 125             
Arg Phe Ser Glu Arg Ile Pro Ala Asp Ala Thr Ser Gly Thr Leu Arg
    130                 135                 140                 
Leu Gly Leu Gln Gly Ser Ser Gly Asn Val Glu Phe Asp Leu Asp Ser
145                 150                 155                 160 
Leu Gln Ile Arg Pro Leu Asp Pro Glu Leu Ser Pro Val Pro Pro Thr
                165                 170                 175     
Pro Glu Gln Ile Arg Glu Cys Glu Leu Ile Glu Ser Arg Leu Arg Ala
            180                 185                 190         
Gly Leu Pro Ala Gln Gln Pro Pro Pro Gly Pro Glu Val Lys Lys Leu
        195                 200                 205             
Leu Glu Arg Gln Asn Gly Asp Gly Thr Phe Arg Asp Leu Asp Tyr Ser
    210                 215                 220                 
Ala Arg Asn Arg Ser Ile Trp Pro Ala Ala Arg His Leu Lys Arg Thr
225                 230                 235                 240 
Phe Glu Leu Ala Leu Ala Arg Ala Thr Pro Gly His Ala Leu Tyr Arg
                245                 250                 255     
Asp Pro Ala Ala Gly Glu Ala Val Arg Lys Ala Val Ala Trp Trp Ala
            260                 265                 270         
Glu Arg Gln Pro Gln Asn Gly Asn Trp Trp Trp Asn Asp Met Tyr Val
        275                 280                 285             
Pro Lys Ile Leu Gly Asn Ile Leu Leu Leu Ser Pro Glu Leu Phe Pro

    290                 295                 300                 
Asp Gly Pro Arg Arg Arg Ala Ala Leu Asn Val Cys Arg Gln Ala Cys
305                 310                 315                 320 
Phe Leu Ser Arg Tyr Thr Gly Asn Asn Arg Val Phe Ile Ala Ala Asn
                325                 330                 335     
Ile Phe Cys Arg Ala Leu Leu Glu Arg Asn Leu Pro Val Met Asp Arg
            340                 345                 350         
Ala Ala Ala Val Leu Ser Glu Glu Ile Arg Phe Ala Pro Ala Glu His
        355                 360                 365             
Lys Thr Ala Trp Ser Phe Gly Gly Ile Arg Ala Asp Gly Cys Tyr His
    370                 375                 380                 
Gln His Gly Pro Gln Ile Gln Phe Gly Asn Tyr Gly Gly Glu Phe Leu
385                 390                 395                 400 
Ala Asn Ile Ala Tyr Trp Ser Asn Ile Leu Lys Glu Thr His Trp Glu
                405                 410                 415     
Leu Ser Pro Glu Gln Trp Arg Ile Met Arg His Leu Thr Phe Asn Gly
            420                 425                 430         
Phe Gln Trp Val Leu Trp Arg Gly Arg Met Asp Leu Leu Ala Cys Gly
        435                 440                 445             
Arg Gln Leu Gly Arg Asn Ala Ala Glu Thr Lys Gly Glu Arg Thr Leu
    450                 455                 460                 
Asn Ala Phe Ala Gln Leu Arg Asn Ala Asp Pro Gly Asp Arg Ala Pro
465                 470                 475                 480 
Tyr Asp Ala Ala Leu Arg Arg Asn Arg Asp Gly Glu Asn Thr Leu Thr
                485                 490                 495     
Gly Asn Arg His Phe Trp Asn Ser Asp Tyr Met Val His Arg Arg Pro
            500                 505                 510         
Thr Trp Tyr Ala Ser Val Arg Met Asn Ser Val Arg Val Arg Pro Ile
        515                 520                 525             
Glu Asp Asp Thr Asn Trp Asp Asn Ala Leu Gly Arg Tyr Phe Ser Asp
    530                 535                 540                 
Gly Ala Cys Leu Val Met Arg Ser Gly Arg Glu Tyr Glu Asn Ile Thr
545                 550                 555                 560 
Ala Cys Trp Asp Trp Thr Arg Leu Pro Gly Thr Thr Leu Pro Lys Thr
                565                 570                 575     
Pro Val Tyr Thr Gly Glu Asp Ala Arg Arg Phe Gly Leu Lys Ile Gly
            580                 585                 590         
Gly Gly Asp Leu Pro Arg Trp Thr His Ser Arg Asn Trp Arg Gln Leu
        595                 600                 605             
Gly Glu Thr Gly Phe Val Gly Gly Val Thr Asp Gly Glu Arg Gly Ala
    610                 615                 620                 
Ala Val Tyr Thr Gln Asp Leu Asp Gly Val Arg Ala Arg Lys Ala Trp
625                 630                 635                 640 
Phe Phe Asp Arg Asp Ala Ile Tyr Cys Leu Gly Ser Gly Ile Thr Ser
                645                 650                 655     
Thr Ser Pro Tyr Glu Val Ala Thr Thr Val Asn Ser Cys Leu Arg Asn
            660                 665                 670         
Gly Glu Ile Gln Gln Gly Asp Gly Trp Phe Arg His Asp Gly Ile Gly
        675                 680                 685             
Tyr Arg Gly Glu Asn Leu Lys Leu Thr Ala Gly Pro Arg Thr Gly Asp
    690                 695                 700                 
Trp Arg Tyr Val Glu Gly Gly Leu Thr Arg Pro Val Pro Glu Thr Lys
705                 710                 715                 720 
Glu Leu Phe Thr Leu Thr Val Glu His Gly Val Lys Pro Arg Asn Ala
                725                 730                 735     
Ser Tyr Ile Tyr Thr Ile Leu Pro Gly Ala Thr Pro Glu Glu Thr Ala
            740                 745                 750         
Gly Thr Pro Pro Gly Arg Val Leu Arg Asn Thr Pro Glu Cys Gln Ala
        755                 760                 765             
Val Glu Phe Ala Asp Gly Val Arg Ala Ala Ile Phe Tyr Glu Pro Gly
    770                 775                 780                 
Arg Leu Asp Asp Phe Glu Thr Asp Thr Pro Gly Val Phe Leu Ile Gly
785                 790                 795                 800 
Lys Gly Thr Val His Ala Ala Asp Pro Thr Gly Arg His Ser Ser Phe
                805                 810                 815     
Thr Leu Lys Leu Asn Gly Val Ser Arg Lys Val Pro Leu Pro Ala Gly
            820                 825                 830         
Glu Phe Ala Gly Gln Ser Val Lys Ile Val Leu Lys
        835                 840                 


<210> 309
<211> 4344
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-24

<400> 309
gggatgccga ggagccgggg cggccgcgcc gcgccggggc cgccgccgcc gccgccgccg 60
ccgggccagg ccccgcgctg gagccgctgg cgggtccctg ggcggctgct gctgctgctg 120
ctgcccgcgc tctgctgcct cccgggcgcc gcgcgggcgg cggcggcggc ggcgggggca 180
gggaaccggg cagcggtggc ggtggcggtg gcgcgggcgg acgaggcgga ggcgcccttc 240
gccgggcaga actggttaaa gtcctatggc tatctgcttc cctatgactc acgggcatct 300
gcgctgcact cagcgaaggc cttgcagtcg gcagtctcca ctatgcagca gttttacggg 360
atcccggtca ccggtgtgtt ggatcagaca acgatcgagt ggatgaagaa accccgatgt 420
ggtgtccctg atcaccccca cttaagccgt aggcggagaa acaagcgcta tgccctgact 480
ggacagaagt ggaggcaaaa acacatcacc tacagcattc acaactatac cccaaaagtg 540
ggtgagctag acacgcggaa agctattcgc caggctttcg atgtgtggca gaaggtgacc 600
ccactgacct ttgaagaggt gccataccat gagatcaaaa gtgaccggaa ggaggcagac 660
atcatgatct tttttgcttc tggtttccat ggcgacagct ccccatttga tggagaaggg 720
ggattcctgg cccatgccta cttccctggc ccagggattg gaggagacac ccactttgac 780
tccgatgagc catggacgct aggaaatgcc aaccatgacg ggaacgacct cttcctggtg 840
gctgtgcatg agctgggcca cgcgctggga ctggagcact ccagcgaccc cagcgccatc 900
atggcgccct tctaccagta catggagacg cacaacttca agctgcccca ggacgatctc 960
cagggcatcc agaagatcta tggaccccca gccgagcctc tggagcccac aaggccactc 1020
cctacactcc ccgtccgcag gatccactca ccatcggaga ggaaacacga gcgccagccc 1080
aggccccctc ggccgcccct cggggaccgg ccatccacac caggcaccaa acccaacatc 1140
tgtgacggca acttcaacac agtggccctc ttccggggcg agatgtttgt ctttaaggat 1200
cgctggttct ggcgtctgcg caataaccga gtgcaggagg gctaccccat gcagatcgag 1260
cagttctgga agggcctgcc tgcccgcatc gacgcagcct atgaaagggc cgatgggaga 1320
tttgtcttct tcaaaggtga caagtattgg gtgtttaagg aggtgacggt ggagcctggg 1380
tacccccaca gcctggggga gctgggcagc tgtttgcccc gtgaaggcat tgacacagct 1440
ctgcgctggg aacctgtggg caagacctac tttttcaaag gcgagcggta ctggcgctac 1500
agcgaggagc ggcgggccac ggaccctggc taccctaagc ccatcaccgt gtggaagggc 1560
atcccacagg ctccccaagg agccttcatc agcaaggaag gatattacac ctatttctac 1620
aagggccggg actactggaa gtttgacaac cagaaactga gcgtggagcc aggctacccg 1680
cgcaacatcc tgcgtgactg gatgggctgc aaccagaagg aggtggagcg gcggaaggag 1740
cggcggctgc cccaggacga cgtggacatc atggtgacca tcaacgatgt gccgggctcc 1800
gtgaacgccg tggccgtggt catcccctgc atcctgtccc tctgcatcct ggtgctggtc 1860
tacaccatct tccagttcaa gaacaagaca ggccctcagc ctgtcaccta ctataagcgg 1920
ccagtccagg aatgggtgtg agcagcccag agccctctct atccacttgg tctggccagc 1980
caggcccttc ctcaccaggg tctgaggggc agctctggcc agtgctcacc agggccagca 2040
gggccctagg ctggggtcgt acagctgaag tggtgggtgc attggcctag gctgagcgtg 2100
gggcagggaa ttatgggggc tgtgccccag ggtgggtgtc tggcacccag ctgccagcct 2160
tctgtcctgg gcaaactact ccctacttaa gggaataggc caggctccat ccggaggcag 2220
ggaccatgcc aggaggagcc cctgtggtca cggcatcctg tggtgtccat gaggtaccac 2280
agctccactc ctggctggaa cccagcaccc tctgtgggaa gccagcacta gctctcatcc 2340
cccatccggg agataccacc agtcctggtc cccttttgcc aacacctgct ggtcagatgt 2400
ccccctaccc ccaccccact gtcctccaag gctacaggac ccctgcttct gacacagtga 2460
gcaacaagcc tgggtttccc tgctggcaga cggcagatcc ctcaggaaac ctgctccact 2520
tgtcagggtc tcttcggaga cccaggattt agggtcacat gctgcaggca gggctgtggc 2580
ccagctgggt ctgacaagga cccagctgtc acatcgtgaa tatttaaatg tcctgtcact 2640
actgtcccat tttgcaaagg ctgcttgagg ctttaggtga actagaggtg actgtcttgg 2700
tgatgaggcc agcatagcgg ccctccccca ggcgacaagg accaaggtgc tgctaaggcc 2760
actctagcgc ccagacaccc cagtagctga gctctgctcc tatggctaca gagctggggc 2820
agaagctgac cccatttctg gaggaagatc cgagtttgtg accgtcctcc actcccctct 2880
attgtcactg tccccagctt tgctccagtc tgtcacttgc agcctggagc tcagcctcac 2940
cagttaggtg aggcagagat ggctgcaggg ccaacactgg cagagcctgg gagtccttcg 3000
gaaggggacc agggcgtctg aagtgctcag tgcccccact actctgaggc cgactccagc 3060
tactctgagg ccgactcaat ctctcggctg gaagcagtgt tttcccagag cttggccctt 3120
gctgacctcg ctcactgggc ccatcttccc acactgctct tagaaggaca cccctaccgg 3180
tagcagcccc aagctgaggg ggctcccttt ttgaccttca ctggcccgcc cttcactgtc 3240
tccagcagga gttcctaggg cttggcctgc cttgctccac agtacggcgg aggcagccct 3300
gcttgtcact gaggagccct agacaaggcc aatgggttca tcaatgccca ctggctctct 3360
gccaaagcca aaaaggtgtc aggcagtctc cagcgtgctg gccgggtctc ggatgccacc 3420
cctgctcact gagcctgcat gggccttgcc cccgaccctg tggtctctgg gattggggtc 3480
ggcttaccct gtagcacaga cagggactcc tgctgccctg ggagctgtct caagcaaaat 3540
ctcttgtccc agaggtgccc atgtgggtcc gctgtgtccc ctgtcatcat ccttgttttt 3600
tctcattttg gccaagggca ggctccctgg gacaggcagg gaacaactgc ggagatatta 3660
gtgattcata ggtttgtaca gtgttttata ctttgcaaag cactttatta gctcacacct 3720
gtccactcac atgaaactcg tgttaggccc tgggaggccg acggtaactc tcaccgtgcc 3780
ctcagatgaa gcacagagag gttgttactt gcccgggcca tccagtgggc tggctgggtc 3840
ttgtgtcccc atctgtggac ccctctaggg tctgagatga gatgagaagt gtctcctgta 3900
tccacctctt cctggcctcc cttcccccac ttcctggtcc ctgtccactc ctcaggttgg 3960
tgctctcact tcttgaaagc tctaggcacc cccgcctccc gccaggctcc ccattggctc 4020
ctggcaggcc agctgagaat gaacaggaga tggaggcagg cagcccaggc tgcagaggtg 4080
agggatgtgg ggccaggccc agagggctca gcctagaggc ttccaatctc agattctcct 4140
gcctgtggtc atctgtttgt ccatcacccc aggacagggc agacagaggg gcaaagcact 4200
gggggcccca gagcctagct tcccctcagc ctgggggaca tcacagcatt tcagtgtcag 4260
tcacatttta aactgatcag cctttgtata atgtttttta aatcatttct aaataaaaca 4320
gaaatacaga gtgaaaaaaa aaaa                                        4344

<210> 310
<211> 645
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-24 precursor

<400> 310
Met Pro Arg Ser Arg Gly Gly Arg Ala Ala Pro Gly Pro Pro Pro Pro
 1               5                  10                  15      
Pro Pro Pro Pro Gly Gln Ala Pro Arg Trp Ser Arg Trp Arg Val Pro
            20                  25                  30          
Gly Arg Leu Leu Leu Leu Leu Leu Pro Ala Leu Cys Cys Leu Pro Gly
        35                  40                  45              
Ala Ala Arg Ala Ala Ala Ala Ala Ala Gly Ala Gly Asn Arg Ala Ala
    50                  55                  60                  
Val Ala Val Ala Val Ala Arg Ala Asp Glu Ala Glu Ala Pro Phe Ala
65                  70                  75                  80  
Gly Gln Asn Trp Leu Lys Ser Tyr Gly Tyr Leu Leu Pro Tyr Asp Ser
                85                  90                  95      
Arg Ala Ser Ala Leu His Ser Ala Lys Ala Leu Gln Ser Ala Val Ser
            100                 105                 110         
Thr Met Gln Gln Phe Tyr Gly Ile Pro Val Thr Gly Val Leu Asp Gln
        115                 120                 125             
Thr Thr Ile Glu Trp Met Lys Lys Pro Arg Cys Gly Val Pro Asp His
    130                 135                 140                 
Pro His Leu Ser Arg Arg Arg Arg Asn Lys Arg Tyr Ala Leu Thr Gly
145                 150                 155                 160 
Gln Lys Trp Arg Gln Lys His Ile Thr Tyr Ser Ile His Asn Tyr Thr
                165                 170                 175     
Pro Lys Val Gly Glu Leu Asp Thr Arg Lys Ala Ile Arg Gln Ala Phe
            180                 185                 190         
Asp Val Trp Gln Lys Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr
        195                 200                 205             
His Glu Ile Lys Ser Asp Arg Lys Glu Ala Asp Ile Met Ile Phe Phe
    210                 215                 220                 
Ala Ser Gly Phe His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly
225                 230                 235                 240 
Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr
                245                 250                 255     
His Phe Asp Ser Asp Glu Pro Trp Thr Leu Gly Asn Ala Asn His Asp
            260                 265                 270         
Gly Asn Asp Leu Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu
        275                 280                 285             
Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile Met Ala Pro Phe Tyr
    290                 295                 300                 
Gln Tyr Met Glu Thr His Asn Phe Lys Leu Pro Gln Asp Asp Leu Gln
305                 310                 315                 320 
Gly Ile Gln Lys Ile Tyr Gly Pro Pro Ala Glu Pro Leu Glu Pro Thr
                325                 330                 335     
Arg Pro Leu Pro Thr Leu Pro Val Arg Arg Ile His Ser Pro Ser Glu
            340                 345                 350         
Arg Lys His Glu Arg Gln Pro Arg Pro Pro Arg Pro Pro Leu Gly Asp
        355                 360                 365             
Arg Pro Ser Thr Pro Gly Thr Lys Pro Asn Ile Cys Asp Gly Asn Phe
    370                 375                 380                 
Asn Thr Val Ala Leu Phe Arg Gly Glu Met Phe Val Phe Lys Asp Arg
385                 390                 395                 400 
Trp Phe Trp Arg Leu Arg Asn Asn Arg Val Gln Glu Gly Tyr Pro Met
                405                 410                 415     
Gln Ile Glu Gln Phe Trp Lys Gly Leu Pro Ala Arg Ile Asp Ala Ala
            420                 425                 430         
Tyr Glu Arg Ala Asp Gly Arg Phe Val Phe Phe Lys Gly Asp Lys Tyr
        435                 440                 445             
Trp Val Phe Lys Glu Val Thr Val Glu Pro Gly Tyr Pro His Ser Leu
    450                 455                 460                 
Gly Glu Leu Gly Ser Cys Leu Pro Arg Glu Gly Ile Asp Thr Ala Leu
465                 470                 475                 480 
Arg Trp Glu Pro Val Gly Lys Thr Tyr Phe Phe Lys Gly Glu Arg Tyr
                485                 490                 495     
Trp Arg Tyr Ser Glu Glu Arg Arg Ala Thr Asp Pro Gly Tyr Pro Lys
            500                 505                 510         
Pro Ile Thr Val Trp Lys Gly Ile Pro Gln Ala Pro Gln Gly Ala Phe
        515                 520                 525             
Ile Ser Lys Glu Gly Tyr Tyr Thr Tyr Phe Tyr Lys Gly Arg Asp Tyr
    530                 535                 540                 
Trp Lys Phe Asp Asn Gln Lys Leu Ser Val Glu Pro Gly Tyr Pro Arg
545                 550                 555                 560 
Asn Ile Leu Arg Asp Trp Met Gly Cys Asn Gln Lys Glu Val Glu Arg
                565                 570                 575     
Arg Lys Glu Arg Arg Leu Pro Gln Asp Asp Val Asp Ile Met Val Thr
            580                 585                 590         
Ile Asn Asp Val Pro Gly Ser Val Asn Ala Val Ala Val Val Ile Pro
        595                 600                 605             
Cys Ile Leu Ser Leu Cys Ile Leu Val Leu Val Tyr Thr Ile Phe Gln
    610                 615                 620                 
Phe Lys Asn Lys Thr Gly Pro Gln Pro Val Thr Tyr Tyr Lys Arg Pro
625                 630                 635                 640 
Val Gln Glu Trp Val
                645 


<210> 311
<211> 490
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-24 mature

<400> 311
Tyr Ala Leu Thr Gly Gln Lys Trp Arg Gln Lys His Ile Thr Tyr Ser
 1               5                  10                  15      
Ile His Asn Tyr Thr Pro Lys Val Gly Glu Leu Asp Thr Arg Lys Ala
            20                  25                  30          
Ile Arg Gln Ala Phe Asp Val Trp Gln Lys Val Thr Pro Leu Thr Phe
        35                  40                  45              
Glu Glu Val Pro Tyr His Glu Ile Lys Ser Asp Arg Lys Glu Ala Asp
    50                  55                  60                  
Ile Met Ile Phe Phe Ala Ser Gly Phe His Gly Asp Ser Ser Pro Phe
65                  70                  75                  80  
Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Gly
                85                  90                  95      
Ile Gly Gly Asp Thr His Phe Asp Ser Asp Glu Pro Trp Thr Leu Gly
            100                 105                 110         
Asn Ala Asn His Asp Gly Asn Asp Leu Phe Leu Val Ala Val His Glu
        115                 120                 125             
Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile
    130                 135                 140                 
Met Ala Pro Phe Tyr Gln Tyr Met Glu Thr His Asn Phe Lys Leu Pro
145                 150                 155                 160 
Gln Asp Asp Leu Gln Gly Ile Gln Lys Ile Tyr Gly Pro Pro Ala Glu
                165                 170                 175     
Pro Leu Glu Pro Thr Arg Pro Leu Pro Thr Leu Pro Val Arg Arg Ile
            180                 185                 190         
His Ser Pro Ser Glu Arg Lys His Glu Arg Gln Pro Arg Pro Pro Arg
        195                 200                 205             
Pro Pro Leu Gly Asp Arg Pro Ser Thr Pro Gly Thr Lys Pro Asn Ile
    210                 215                 220                 
Cys Asp Gly Asn Phe Asn Thr Val Ala Leu Phe Arg Gly Glu Met Phe
225                 230                 235                 240 
Val Phe Lys Asp Arg Trp Phe Trp Arg Leu Arg Asn Asn Arg Val Gln
                245                 250                 255     
Glu Gly Tyr Pro Met Gln Ile Glu Gln Phe Trp Lys Gly Leu Pro Ala
            260                 265                 270         
Arg Ile Asp Ala Ala Tyr Glu Arg Ala Asp Gly Arg Phe Val Phe Phe
        275                 280                 285             
Lys Gly Asp Lys Tyr Trp Val Phe Lys Glu Val Thr Val Glu Pro Gly
    290                 295                 300                 
Tyr Pro His Ser Leu Gly Glu Leu Gly Ser Cys Leu Pro Arg Glu Gly
305                 310                 315                 320 
Ile Asp Thr Ala Leu Arg Trp Glu Pro Val Gly Lys Thr Tyr Phe Phe
                325                 330                 335     
Lys Gly Glu Arg Tyr Trp Arg Tyr Ser Glu Glu Arg Arg Ala Thr Asp
            340                 345                 350         
Pro Gly Tyr Pro Lys Pro Ile Thr Val Trp Lys Gly Ile Pro Gln Ala
        355                 360                 365             
Pro Gln Gly Ala Phe Ile Ser Lys Glu Gly Tyr Tyr Thr Tyr Phe Tyr
    370                 375                 380                 
Lys Gly Arg Asp Tyr Trp Lys Phe Asp Asn Gln Lys Leu Ser Val Glu
385                 390                 395                 400 
Pro Gly Tyr Pro Arg Asn Ile Leu Arg Asp Trp Met Gly Cys Asn Gln
                405                 410                 415     
Lys Glu Val Glu Arg Arg Lys Glu Arg Arg Leu Pro Gln Asp Asp Val
            420                 425                 430         
Asp Ile Met Val Thr Ile Asn Asp Val Pro Gly Ser Val Asn Ala Val
        435                 440                 445             
Ala Val Val Ile Pro Cys Ile Leu Ser Leu Cys Ile Leu Val Leu Val
    450                 455                 460                 
Tyr Thr Ile Phe Gln Phe Lys Asn Lys Thr Gly Pro Gln Pro Val Thr
465                 470                 475                 480 
Tyr Tyr Lys Arg Pro Val Gln Glu Trp Val
                485                 490 


<210> 312
<211> 3565
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-25

<400> 312
gattcccggg cccacccgac ccagcggcgc gaccctggcc ctccgggacc ctccgctgac 60
tccaccgcgc acttcccggg acccccacac acatcccagc cctccggccg atccctccct 120
actcggtgcc gggtgccccc cgccctctcc aggcccggat ctcctccccc aggtccccgg 180
ggcggcccca gccaggcccc cttcgaaccc cgccggcggc ccgggctggg gcgcaccatg 240
cggctgcggc tccggcttct ggcgctgctg cttctgctgc tggcaccgcc cgcgcgcgcc 300
ccgaagccct cggcgcagga cgtgagcctg ggcgtggact ggctgactcg ctatggttac 360
ctgccgccac cccaccctgc ccaggcccag ctgcagagcc ctgagaagtt gcgcgatgcc 420
atcaaagtca tgcagaggtt cgcggggctg ccggagaccg gccgcatgga cccagggaca 480
gtggccacca tgcgtaagcc ccgctgctcc ctgcctgacg tgctgggggt ggcggggctg 540
gtcaggcggc gtcgccggta cgctctgagc ggcagcgtgt ggaagaagcg aaccctgaca 600
tggagggtac gttccttccc ccagagctcc cagctgagcc aggagaccgt gcgggtcctc 660
atgagctatg ccctgatggc ctggggcatg gagtcaggcc tcacatttca tgaggtggat 720
tccccccagg gccaggagcc cgacatcctc atcgactttg cccgcgcctt ccaccaggac 780
agctacccct tcgacgggtt ggggggcacc ctagcccatg ccttcttccc tggggagcac 840
cccatctccg gggacactca ctttgacgat gaggagacct ggacttttgg gtcaaaagac 900
ggcgagggga ccgacctgtt tgccgtggct gtccatgagt ttggccacgc cctgggcctg 960
ggccactcct cagcccccaa ctccattatg aggcccttct accagggtcc ggtgggcgac 1020
cctgacaagt accgcctgtc tcaggatgac cgcgatggcc tgcagcaact ctatgggaag 1080
gcgccccaaa ccccatatga caagcccaca aggaaacccc tggctcctcc gccccagccc 1140
ccggcctcgc ccacacacag cccatccttc cccatccctg atcgatgtga gggcaatttt 1200
gacgccatcg ccaacatccg aggggaaact ttcttcttca aaggcccctg gttctggcgc 1260
ctccagccct ccggacagct ggtgtccccg cgacccgcac ggctgcaccg cttctgggag 1320
gggctgcccg cccaggtgag ggtggtgcag gccgcctatg ctcggcaccg agacggccga 1380
atcctcctct ttagcgggcc ccagttctgg gtgttccagg accggcagct ggagggcggg 1440
gcgcggccgc tcacggagct ggggctgccc ccgggagagg aggtggacgc cgtgttctcg 1500
tggccacaga acgggaagac ctacctggtc cgcggccggc agtactggcg ctacgacgag 1560
gcggcggcgc gcccggaccc cggctaccct cgcgacctga gcctctggga aggcgcgccc 1620
ccctcccctg acgatgtcac cgtcagcaac gcaggtgaca cctacttctt caagggcgcc 1680
cactactggc gcttccccaa gaacagcatc aagaccgagc cggacgcccc ccagcccatg 1740
gggcccaact ggctggactg ccccgccccg agctctggtc cccgcgcccc caggcccccc 1800
aaagcgaccc ccgtgtccga aacctgcgat tgtcagtgcg agctcaacca ggccgcagga 1860
cgttggcctg ctcccatccc gctgctcctc ttgcccctgc tggtgggggg tgtagcctcc 1920
cgctgatggg gggagccatc cagaccgaac agcgccctcc acggccgagt cccccgccgc 1980
tggacctggt cgggggttgt gaggcgctgc ggaggcccct tgtctgttcc cacggacggg 2040
ggctcgggcg cggactaagc aggggggatc tcccgcgcag gggcggcggc ggcggggacc 2100
ggtcgcctgg cgctgggctc agtctcctca gggtctgaga ccccggcgct gccaccggaa 2160
cccgccttca ggggcgcacg cgcgctggga ccatgcgtcg gtcgtcgccc ccgtcgttcc 2220
ctcccggctg ccgccagggg gcggtcggac cccgcctccc gagcccgggg aggggcgggg 2280
aggacaaggg gcgggcccgc ggcctcaccc ggagggacgg cagccccggt cgcgcgctgg 2340
ccccgcagga ccttcctttt ccaggaagag ccagcttttc tcggagcgca gtcctgggac 2400
tctccgcagc cccgccccgc ctggccactg cgtctggcat tcctgggtcg ttagaggaca 2460
ggcctgactg cgaagctgtg ccttgcccct ctcccacccg cagtttctca ccccgttctg 2520
ctcccacaag gcccccctac agtcactgcc acactggtgg ggacctggga cccagacccg 2580
gaaccagccc agatatcacc cctgaggacc catgcgccac gtcctgggtg gtggaatcag 2640
tggctggagg gacgaccctt gctctccagg ctgttaacct tttccgttgc tcccccgcca 2700
cccacctcct cctccccagg ccacccaact tgggcacctc cctgggccca gaactgcctt 2760
ccattcaatg gggaaccctt ctatccccaa gaaccccttc cctgcttgca ccctggagag 2820
aacagcttga ctcccatcaa ctcaacgctg gtggaaagac agggaccgaa ccctggctca 2880
ggcctggtca ttgcctcctc agcactccct cctgggaggc cttagctcta gagtgagggg 2940
tgggtggaac ctgggggcac ctcgttcacc ctgtccccac tccccacagt tttaggatct 3000
aaatgattgc ctctggaact attcttctag actatcccac atcagaatca ctgggaaatt 3060
taagtttgca gatcccacac tcaccctgaa tcctcactca gggtggggtc aggaatctgc 3120
attttaacta gtcgcgggga ttgtgggggg cagtagctgg ctgtttcgtg gcatttctgt 3180
ggctctgcag tgttcctcca ccccaggacc aatatgttca ggccacaccg atggcctgaa 3240
ccccatgggt agagtcactt aggggccact tcctaagttg ctgtccagcc tcagtgaccc 3300
cctagtgctt cctggagctg aggctgtggg cggctgtccc agcaaccatg cgaggggttg 3360
ccccagttgc tcatacaaac agatcagcat gaggacagaa ggcaggagac tttggtcagt 3420
tacctgggaa ttctgggctg ccaggaaacg atttgggcct ctgtcagttt cttttccatg 3480
tatgaggagg gggaaatttg tatattagaa acttattcat cccactcagg acaataaaaa 3540
cgaatgtaca aaaaaaaaaa aaaaa                                       3565

<210> 313
<211> 562
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-25 precursor

<400> 313
Met Arg Leu Arg Leu Arg Leu Leu Ala Leu Leu Leu Leu Leu Leu Ala
 1               5                  10                  15      
Pro Pro Ala Arg Ala Pro Lys Pro Ser Ala Gln Asp Val Ser Leu Gly
            20                  25                  30          
Val Asp Trp Leu Thr Arg Tyr Gly Tyr Leu Pro Pro Pro His Pro Ala
        35                  40                  45              
Gln Ala Gln Leu Gln Ser Pro Glu Lys Leu Arg Asp Ala Ile Lys Val
    50                  55                  60                  
Met Gln Arg Phe Ala Gly Leu Pro Glu Thr Gly Arg Met Asp Pro Gly
65                  70                  75                  80  
Thr Val Ala Thr Met Arg Lys Pro Arg Cys Ser Leu Pro Asp Val Leu
                85                  90                  95      
Gly Val Ala Gly Leu Val Arg Arg Arg Arg Arg Tyr Ala Leu Ser Gly
            100                 105                 110         
Ser Val Trp Lys Lys Arg Thr Leu Thr Trp Arg Val Arg Ser Phe Pro
        115                 120                 125             
Gln Ser Ser Gln Leu Ser Gln Glu Thr Val Arg Val Leu Met Ser Tyr
    130                 135                 140                 
Ala Leu Met Ala Trp Gly Met Glu Ser Gly Leu Thr Phe His Glu Val
145                 150                 155                 160 
Asp Ser Pro Gln Gly Gln Glu Pro Asp Ile Leu Ile Asp Phe Ala Arg
                165                 170                 175     
Ala Phe His Gln Asp Ser Tyr Pro Phe Asp Gly Leu Gly Gly Thr Leu
            180                 185                 190         
Ala His Ala Phe Phe Pro Gly Glu His Pro Ile Ser Gly Asp Thr His
        195                 200                 205             
Phe Asp Asp Glu Glu Thr Trp Thr Phe Gly Ser Lys Asp Gly Glu Gly
    210                 215                 220                 
Thr Asp Leu Phe Ala Val Ala Val His Glu Phe Gly His Ala Leu Gly
225                 230                 235                 240 
Leu Gly His Ser Ser Ala Pro Asn Ser Ile Met Arg Pro Phe Tyr Gln
                245                 250                 255     
Gly Pro Val Gly Asp Pro Asp Lys Tyr Arg Leu Ser Gln Asp Asp Arg
            260                 265                 270         
Asp Gly Leu Gln Gln Leu Tyr Gly Lys Ala Pro Gln Thr Pro Tyr Asp
        275                 280                 285             
Lys Pro Thr Arg Lys Pro Leu Ala Pro Pro Pro Gln Pro Pro Ala Ser
    290                 295                 300                 
Pro Thr His Ser Pro Ser Phe Pro Ile Pro Asp Arg Cys Glu Gly Asn
305                 310                 315                 320 
Phe Asp Ala Ile Ala Asn Ile Arg Gly Glu Thr Phe Phe Phe Lys Gly
                325                 330                 335     
Pro Trp Phe Trp Arg Leu Gln Pro Ser Gly Gln Leu Val Ser Pro Arg
            340                 345                 350         
Pro Ala Arg Leu His Arg Phe Trp Glu Gly Leu Pro Ala Gln Val Arg
        355                 360                 365             
Val Val Gln Ala Ala Tyr Ala Arg His Arg Asp Gly Arg Ile Leu Leu
    370                 375                 380                 
Phe Ser Gly Pro Gln Phe Trp Val Phe Gln Asp Arg Gln Leu Glu Gly
385                 390                 395                 400 
Gly Ala Arg Pro Leu Thr Glu Leu Gly Leu Pro Pro Gly Glu Glu Val
                405                 410                 415     
Asp Ala Val Phe Ser Trp Pro Gln Asn Gly Lys Thr Tyr Leu Val Arg
            420                 425                 430         
Gly Arg Gln Tyr Trp Arg Tyr Asp Glu Ala Ala Ala Arg Pro Asp Pro
        435                 440                 445             
Gly Tyr Pro Arg Asp Leu Ser Leu Trp Glu Gly Ala Pro Pro Ser Pro
    450                 455                 460                 
Asp Asp Val Thr Val Ser Asn Ala Gly Asp Thr Tyr Phe Phe Lys Gly
465                 470                 475                 480 
Ala His Tyr Trp Arg Phe Pro Lys Asn Ser Ile Lys Thr Glu Pro Asp
                485                 490                 495     
Ala Pro Gln Pro Met Gly Pro Asn Trp Leu Asp Cys Pro Ala Pro Ser
            500                 505                 510         
Ser Gly Pro Arg Ala Pro Arg Pro Pro Lys Ala Thr Pro Val Ser Glu
        515                 520                 525             
Thr Cys Asp Cys Gln Cys Glu Leu Asn Gln Ala Ala Gly Arg Trp Pro
    530                 535                 540                 
Ala Pro Ile Pro Leu Leu Leu Leu Pro Leu Leu Val Gly Gly Val Ala
545                 550                 555                 560 
Ser Arg
        


<210> 314
<211> 455
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-25 mature

<400> 314
Tyr Ala Leu Ser Gly Ser Val Trp Lys Lys Arg Thr Leu Thr Trp Arg
 1               5                  10                  15      
Val Arg Ser Phe Pro Gln Ser Ser Gln Leu Ser Gln Glu Thr Val Arg
            20                  25                  30          
Val Leu Met Ser Tyr Ala Leu Met Ala Trp Gly Met Glu Ser Gly Leu
        35                  40                  45              
Thr Phe His Glu Val Asp Ser Pro Gln Gly Gln Glu Pro Asp Ile Leu
    50                  55                  60                  
Ile Asp Phe Ala Arg Ala Phe His Gln Asp Ser Tyr Pro Phe Asp Gly
65                  70                  75                  80  
Leu Gly Gly Thr Leu Ala His Ala Phe Phe Pro Gly Glu His Pro Ile
                85                  90                  95      
Ser Gly Asp Thr His Phe Asp Asp Glu Glu Thr Trp Thr Phe Gly Ser
            100                 105                 110         
Lys Asp Gly Glu Gly Thr Asp Leu Phe Ala Val Ala Val His Glu Phe
        115                 120                 125             
Gly His Ala Leu Gly Leu Gly His Ser Ser Ala Pro Asn Ser Ile Met
    130                 135                 140                 
Arg Pro Phe Tyr Gln Gly Pro Val Gly Asp Pro Asp Lys Tyr Arg Leu
145                 150                 155                 160 
Ser Gln Asp Asp Arg Asp Gly Leu Gln Gln Leu Tyr Gly Lys Ala Pro
                165                 170                 175     
Gln Thr Pro Tyr Asp Lys Pro Thr Arg Lys Pro Leu Ala Pro Pro Pro
            180                 185                 190         
Gln Pro Pro Ala Ser Pro Thr His Ser Pro Ser Phe Pro Ile Pro Asp
        195                 200                 205             
Arg Cys Glu Gly Asn Phe Asp Ala Ile Ala Asn Ile Arg Gly Glu Thr
    210                 215                 220                 
Phe Phe Phe Lys Gly Pro Trp Phe Trp Arg Leu Gln Pro Ser Gly Gln
225                 230                 235                 240 
Leu Val Ser Pro Arg Pro Ala Arg Leu His Arg Phe Trp Glu Gly Leu
                245                 250                 255     
Pro Ala Gln Val Arg Val Val Gln Ala Ala Tyr Ala Arg His Arg Asp
            260                 265                 270         
Gly Arg Ile Leu Leu Phe Ser Gly Pro Gln Phe Trp Val Phe Gln Asp
        275                 280                 285             
Arg Gln Leu Glu Gly Gly Ala Arg Pro Leu Thr Glu Leu Gly Leu Pro
    290                 295                 300                 
Pro Gly Glu Glu Val Asp Ala Val Phe Ser Trp Pro Gln Asn Gly Lys
305                 310                 315                 320 
Thr Tyr Leu Val Arg Gly Arg Gln Tyr Trp Arg Tyr Asp Glu Ala Ala
                325                 330                 335     
Ala Arg Pro Asp Pro Gly Tyr Pro Arg Asp Leu Ser Leu Trp Glu Gly
            340                 345                 350         
Ala Pro Pro Ser Pro Asp Asp Val Thr Val Ser Asn Ala Gly Asp Thr
        355                 360                 365             
Tyr Phe Phe Lys Gly Ala His Tyr Trp Arg Phe Pro Lys Asn Ser Ile
    370                 375                 380                 
Lys Thr Glu Pro Asp Ala Pro Gln Pro Met Gly Pro Asn Trp Leu Asp
385                 390                 395                 400 
Cys Pro Ala Pro Ser Ser Gly Pro Arg Ala Pro Arg Pro Pro Lys Ala
                405                 410                 415     
Thr Pro Val Ser Glu Thr Cys Asp Cys Gln Cys Glu Leu Asn Gln Ala
            420                 425                 430         
Ala Gly Arg Trp Pro Ala Pro Ile Pro Leu Leu Leu Leu Pro Leu Leu
        435                 440                 445             
Val Gly Gly Val Ala Ser Arg
    450                 455 


<210> 315
<211> 1919
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-21

<400> 315
atgctcgccg cctccatctt ccgtccgaca ctgctgctct gctggctggc tgctccctgg 60
cccacccagc ccgagagtct cttccacagc cgggaccgct cggacctgga gccgtcccca 120
ctgcgccagg ccaagcccat tgccgacctc cacgctgctc agcggttcct gtccagatac 180
ggctggtcag gggtgtgggc ggcctggggg cccagtcccg aggggccgcc ggagaccccc 240
aagggcgccg ccctggccga ggcggtgcgc aggttccagc gggcgaacgc gctgccggcc 300
agcggggagc tggacgcggc caccctagcg gccatgaacc ggccgcgctg cggggtcccg 360
gacatgcgcc caccgccccc ctccgccccg ccttcgcccc cgggcccgcc ccccagagcc 420
cgctccaggc gctccccgcg ggcgccgctg tccttgtccc ggcggggttg gcagccccgg 480
ggctaccccg acggcggagc tgcccaggcc ttctccaaga ggacgctgag ctggcggctg 540
ctgggcgagg ccctgagcag ccaactgtcc gtggccgacc agcggcgcat tgtggcgctg 600
gccttcagga tgtggagcga ggtgacgccg ctggacttcc gcgaggacct ggccgccccc 660
ggggccgcgg tcgacatcaa gctgggcttt gggagaggcc ggcacctggg ctgtccgcgg 720
gccttcgatg ggagcgggca ggagtttgca cacgcctggc gcctaggtga cattcacttt 780
gacgacgacg agcacttcac acctcccacc agtgacacgg gcatcagcct tctcaaggtg 840
gccgtccatg aaattggcca tgtcctgggc ttgcctcaca cctacaggac gggatccata 900
atgcaaccaa attacattcc ccaggagcct gcctttgagt tggactggtc agacaggaaa 960
gcaattcaaa agctgtatgg ctcctgtgag ggatcatttg atactgcgtt tgactggatt 1020
cgcaaagaga gaaaccaata tggagaggtg atggtgagat ttagcacata tttcttccgt 1080
aacagctggt actggcttta tgaaaatcga aacaatagga cacgctatgg ggaccctatc 1140
caaatcctca ctggctggcc tggaatccca acacacaaca tagatgcctt tgttcacatc 1200
tggacatgga aaagagatga acgttatttt tttcaaggaa atcaatactg gagatatgac 1260
agtgacaagg atcaggccct cacagaagat gaacaaggaa aaagctatcc caaattgatt 1320
tcagaaggat ttcctggcat cccaagtccc ctagacacgg cgttttatga ccgaagacag 1380
aagttaattt acttcttcaa ggagtccctt gtatttgcat ttgatgtcaa cagaaatcga 1440
gtacttaatt cttatccaaa gaggattact gaagtttttc cagcagtaat accacaaaat 1500
catcctttca gaaatataga ttccgcttat tactcctatg catacaactc cattttcttt 1560
ttcaaaggca atgcatactg gaaggtagtt aatgacaagg acaaacaaca gaattcctgg 1620
cttcctgcta atggcttatt tccaaaaaag tttatttcag agaagtggtt tgatgtttgt 1680
gacgtccata tctccacact gaacatgtaa taagaaaaag taggaaatgg agggtcatag 1740
gacttcgcta aaattctgat actgtttaca aagaaaaccg gattttcagt agctgaagaa 1800
aatatggcac tgtaagttaa aacccaatgg gaaaagcctt agttgaactt ttaaaatact 1860
tgatttaaaa acaattgctc aggcaaaaca taattcataa actaaaaggt ttaaaaaaa  1919

<210> 316
<211> 569
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-21 precursor

<400> 316
Met Leu Ala Ala Ser Ile Phe Arg Pro Thr Leu Leu Leu Cys Trp Leu
 1               5                  10                  15      
Ala Ala Pro Trp Pro Thr Gln Pro Glu Ser Leu Phe His Ser Arg Asp
            20                  25                  30          
Arg Ser Asp Leu Glu Pro Ser Pro Leu Arg Gln Ala Lys Pro Ile Ala
        35                  40                  45              
Asp Leu His Ala Ala Gln Arg Phe Leu Ser Arg Tyr Gly Trp Ser Gly
    50                  55                  60                  
Val Trp Ala Ala Trp Gly Pro Ser Pro Glu Gly Pro Pro Glu Thr Pro
65                  70                  75                  80  
Lys Gly Ala Ala Leu Ala Glu Ala Val Arg Arg Phe Gln Arg Ala Asn
                85                  90                  95      
Ala Leu Pro Ala Ser Gly Glu Leu Asp Ala Ala Thr Leu Ala Ala Met
            100                 105                 110         
Asn Arg Pro Arg Cys Gly Val Pro Asp Met Arg Pro Pro Pro Pro Ser
        115                 120                 125             
Ala Pro Pro Ser Pro Pro Gly Pro Pro Pro Arg Ala Arg Ser Arg Arg
    130                 135                 140                 
Ser Pro Arg Ala Pro Leu Ser Leu Ser Arg Arg Gly Trp Gln Pro Arg
145                 150                 155                 160 
Gly Tyr Pro Asp Gly Gly Ala Ala Gln Ala Phe Ser Lys Arg Thr Leu
                165                 170                 175     
Ser Trp Arg Leu Leu Gly Glu Ala Leu Ser Ser Gln Leu Ser Ala Ala
            180                 185                 190         
Asp Gln Arg Arg Ile Val Ala Leu Ala Phe Arg Met Trp Ser Glu Val
        195                 200                 205             
Thr Pro Leu Asp Phe Arg Glu Asp Leu Ala Ala Pro Gly Ala Ala Val
    210                 215                 220                 
Asp Ile Lys Leu Gly Phe Gly Arg Gly Arg His Leu Gly Cys Pro Arg
225                 230                 235                 240 
Ala Phe Asp Gly Ser Gly Gln Glu Phe Ala His Ala Trp Arg Leu Gly
                245                 250                 255     
Asp Ile His Phe Asp Asp Asp Glu His Phe Thr Pro Pro Thr Ser Asp
            260                 265                 270         
Thr Gly Ile Ser Leu Leu Lys Val Ala Val His Glu Ile Gly His Val
        275                 280                 285             
Leu Gly Leu Pro His Thr Tyr Arg Thr Gly Ser Ile Met Gln Pro Asn
    290                 295                 300                 
Tyr Ile Pro Gln Glu Pro Ala Phe Glu Leu Asp Trp Ser Asp Arg Lys
305                 310                 315                 320 
Ala Ile Gln Lys Leu Tyr Gly Ser Cys Glu Gly Ser Phe Asp Thr Ala
                325                 330                 335     
Phe Asp Trp Ile Arg Lys Glu Arg Asn Gln Tyr Gly Glu Val Met Val
            340                 345                 350         
Arg Phe Ser Thr Tyr Phe Phe Arg Asn Ser Trp Tyr Trp Leu Tyr Glu
        355                 360                 365             
Asn Arg Asn Asn Arg Thr Arg Tyr Gly Asp Pro Ile Gln Ile Leu Thr
    370                 375                 380                 
Gly Trp Pro Gly Ile Pro Thr His Asn Ile Asp Ala Phe Val His Ile
385                 390                 395                 400 
Trp Thr Trp Lys Arg Asp Glu Arg Tyr Phe Phe Gln Gly Asn Gln Tyr
                405                 410                 415     
Trp Arg Tyr Asp Ser Asp Lys Asp Gln Ala Leu Thr Glu Asp Glu Gln
            420                 425                 430         
Gly Lys Ser Tyr Pro Lys Leu Ile Ser Glu Gly Phe Pro Gly Ile Pro
        435                 440                 445             
Ser Pro Leu Asp Thr Ala Phe Tyr Asp Arg Arg Gln Lys Leu Ile Tyr
    450                 455                 460                 
Phe Phe Lys Glu Ser Leu Val Phe Ala Phe Asp Val Asn Arg Asn Arg
465                 470                 475                 480 
Val Leu Asn Ser Tyr Pro Lys Arg Ile Thr Glu Val Phe Pro Ala Val
                485                 490                 495     
Ile Pro Gln Asn His Pro Phe Arg Asn Ile Asp Ser Ala Tyr Tyr Ser
            500                 505                 510         
Tyr Ala Tyr Asn Ser Ile Phe Phe Phe Lys Gly Asn Ala Tyr Trp Lys
        515                 520                 525             
Val Val Asn Asp Lys Asp Lys Gln Gln Asn Ser Trp Leu Pro Ala Asn
    530                 535                 540                 
Gly Leu Phe Pro Lys Lys Phe Ile Ser Glu Lys Trp Phe Asp Val Cys
545                 550                 555                 560 
Asp Val His Ile Ser Thr Leu Asn Met
                565                 


<210> 317
<211> 425
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-21 mature

<400> 317
Ser Pro Arg Ala Pro Leu Ser Leu Ser Arg Arg Gly Trp Gln Pro Arg
 1               5                  10                  15      
Gly Tyr Pro Asp Gly Gly Ala Ala Gln Ala Phe Ser Lys Arg Thr Leu
            20                  25                  30          
Ser Trp Arg Leu Leu Gly Glu Ala Leu Ser Ser Gln Leu Ser Ala Ala
        35                  40                  45              
Asp Gln Arg Arg Ile Val Ala Leu Ala Phe Arg Met Trp Ser Glu Val
    50                  55                  60                  
Thr Pro Leu Asp Phe Arg Glu Asp Leu Ala Ala Pro Gly Ala Ala Val
65                  70                  75                  80  
Asp Ile Lys Leu Gly Phe Gly Arg Gly Arg His Leu Gly Cys Pro Arg
                85                  90                  95      
Ala Phe Asp Gly Ser Gly Gln Glu Phe Ala His Ala Trp Arg Leu Gly
            100                 105                 110         
Asp Ile His Phe Asp Asp Asp Glu His Phe Thr Pro Pro Thr Ser Asp
        115                 120                 125             
Thr Gly Ile Ser Leu Leu Lys Val Ala Val His Glu Ile Gly His Val
    130                 135                 140                 
Leu Gly Leu Pro His Thr Tyr Arg Thr Gly Ser Ile Met Gln Pro Asn
145                 150                 155                 160 
Tyr Ile Pro Gln Glu Pro Ala Phe Glu Leu Asp Trp Ser Asp Arg Lys
                165                 170                 175     
Ala Ile Gln Lys Leu Tyr Gly Ser Cys Glu Gly Ser Phe Asp Thr Ala
            180                 185                 190         
Phe Asp Trp Ile Arg Lys Glu Arg Asn Gln Tyr Gly Glu Val Met Val
        195                 200                 205             
Arg Phe Ser Thr Tyr Phe Phe Arg Asn Ser Trp Tyr Trp Leu Tyr Glu
    210                 215                 220                 
Asn Arg Asn Asn Arg Thr Arg Tyr Gly Asp Pro Ile Gln Ile Leu Thr
225                 230                 235                 240 
Gly Trp Pro Gly Ile Pro Thr His Asn Ile Asp Ala Phe Val His Ile
                245                 250                 255     
Trp Thr Trp Lys Arg Asp Glu Arg Tyr Phe Phe Gln Gly Asn Gln Tyr
            260                 265                 270         
Trp Arg Tyr Asp Ser Asp Lys Asp Gln Ala Leu Thr Glu Asp Glu Gln
        275                 280                 285             
Gly Lys Ser Tyr Pro Lys Leu Ile Ser Glu Gly Phe Pro Gly Ile Pro
    290                 295                 300                 
Ser Pro Leu Asp Thr Ala Phe Tyr Asp Arg Arg Gln Lys Leu Ile Tyr
305                 310                 315                 320 
Phe Phe Lys Glu Ser Leu Val Phe Ala Phe Asp Val Asn Arg Asn Arg
                325                 330                 335     
Val Leu Asn Ser Tyr Pro Lys Arg Ile Thr Glu Val Phe Pro Ala Val
            340                 345                 350         
Ile Pro Gln Asn His Pro Phe Arg Asn Ile Asp Ser Ala Tyr Tyr Ser
        355                 360                 365             
Tyr Ala Tyr Asn Ser Ile Phe Phe Phe Lys Gly Asn Ala Tyr Trp Lys
    370                 375                 380                 
Val Val Asn Asp Lys Asp Lys Gln Gln Asn Ser Trp Leu Pro Ala Asn
385                 390                 395                 400 
Gly Leu Phe Pro Lys Lys Phe Ile Ser Glu Lys Trp Phe Asp Val Cys
                405                 410                 415     
Asp Val His Ile Ser Thr Leu Asn Met
            420                 425 


<210> 318
<211> 1246
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-23

<400> 318
ctgccccatg cagccctgag ccccacagca agtctgccat gggccgcggg gcccgtgtcc 60
cctcggaggc cccgggggca ggcgtcgagc gccgctggct tggagccgcg ctggtcgccc 120
tgtgcctcct ccccgcgctg gtgctgctgg cccggctggg ggccccggcg gtgccggcct 180
ggagcgcagc gcagggagac gtcgctgcgc tgggcctctc ggcggtcccc cccacccggg 240
tcccgggccc actggccccc cgcagacgcc gctacacgct gactccagcc aggctgcgct 300
gggaccactt caacctcacc tacaggatcc tctccttccc gcggaacctg ctgagcccgc 360
gggagacgcg gcgggcccta gctgccgcct tccgcatgtg gagcgacgtg tcccccttca 420
gcttccgcga ggtggccccc gagcagccca gcgacctccg gataggcttc tacccgatca 480
accacacgga ctgcctggtc tccgcgctgc accactgctt cgacggcccc acgggggagc 540
tggcccacgc cttcttcccc ccgcacggcg gcatccactt cgacgacagc gagtactggg 600
tcctgggccc cacgcgctac agctggaaga aaggcgtgtg gctcacggac ctggtgcacg 660
tggcggccca cgagatcggc cacgcgctgg gcctgatgca ctcacaacac ggccgggcgc 720
tcatgcacct gaacgccacg ctgcgcggct ggaaggcgtt gtcccaggac gagctgtggg 780
ggctgcaccg gctctacgga tgcctcgaca ggctgttcgt gtgcgcgtcc tgggcgcgga 840
ggggcttctg cgacgctcgc cggcggctca tgaagaggct ctgccccagc agctgcgact 900
tctgctacga attccccttc cccacggtgg ccaccacccc accgcccccc aggaccaaaa 960
ccaggctggt gcccgagggc aggaacgtga ccttccgctg cggccagaag atcctccaca 1020
agaaagggaa agtgtactgg tacaaggacc aggagcccct ggagttctcc taccccggct 1080
acctggccct gggcgaggcg cacctgagca tcatcgccaa cgccgtcaat gagggcacct 1140
acacctgcgt ggtgcgccgc cagcagcgcg tgctgaccac ctactcctgg cgagtccgtg 1200
tgcggggctg agcccggctg ataaagcact ttctctctga aaaaaa                1246

<210> 319
<211> 390
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-23 precursor

<400> 319
Met Gly Arg Gly Ala Arg Val Pro Ser Glu Ala Pro Gly Ala Gly Val
 1               5                  10                  15      
Glu Arg Arg Trp Leu Gly Ala Ala Leu Val Ala Leu Cys Leu Leu Pro
            20                  25                  30          
Ala Leu Val Leu Leu Ala Arg Leu Gly Ala Pro Ala Val Pro Ala Trp
        35                  40                  45              
Ser Ala Ala Gln Gly Asp Val Ala Ala Leu Gly Leu Ser Ala Val Pro
    50                  55                  60                  
Pro Thr Arg Val Pro Gly Pro Leu Ala Pro Arg Arg Arg Arg Tyr Thr
65                  70                  75                  80  
Leu Thr Pro Ala Arg Leu Arg Trp Asp His Phe Asn Leu Thr Tyr Arg
                85                  90                  95      
Ile Leu Ser Phe Pro Arg Asn Leu Leu Ser Pro Arg Glu Thr Arg Arg
            100                 105                 110         
Ala Leu Ala Ala Ala Phe Arg Met Trp Ser Asp Val Ser Pro Phe Ser
        115                 120                 125             
Phe Arg Glu Val Ala Pro Glu Gln Pro Ser Asp Leu Arg Ile Gly Phe
    130                 135                 140                 
Tyr Pro Ile Asn His Thr Asp Cys Leu Val Ser Ala Leu His His Cys
145                 150                 155                 160 
Phe Asp Gly Pro Thr Gly Glu Leu Ala His Ala Phe Phe Pro Pro His
                165                 170                 175     
Gly Gly Ile His Phe Asp Asp Ser Glu Tyr Trp Val Leu Gly Pro Thr
            180                 185                 190         
Arg Tyr Ser Trp Lys Lys Gly Val Trp Leu Thr Asp Leu Val His Val
        195                 200                 205             
Ala Ala His Glu Ile Gly His Ala Leu Gly Leu Met His Ser Gln His
    210                 215                 220                 
Gly Arg Ala Leu Met His Leu Asn Ala Thr Leu Arg Gly Trp Lys Ala
225                 230                 235                 240 
Leu Ser Gln Asp Glu Leu Trp Gly Leu His Arg Leu Tyr Gly Cys Leu
                245                 250                 255     
Asp Arg Leu Phe Val Cys Ala Ser Trp Ala Arg Arg Gly Phe Cys Asp
            260                 265                 270         
Ala Arg Arg Arg Leu Met Lys Arg Leu Cys Pro Ser Ser Cys Asp Phe
        275                 280                 285             
Cys Tyr Glu Phe Pro Phe Pro Thr Val Ala Thr Thr Pro Pro Pro Pro
    290                 295                 300                 
Arg Thr Lys Thr Arg Leu Val Pro Glu Gly Arg Asn Val Thr Phe Arg
305                 310                 315                 320 
Cys Gly Gln Lys Ile Leu His Lys Lys Gly Lys Val Tyr Trp Tyr Lys
                325                 330                 335     
Asp Gln Glu Pro Leu Glu Phe Ser Tyr Pro Gly Tyr Leu Ala Leu Gly
            340                 345                 350         
Glu Ala His Leu Ser Ile Ile Ala Asn Ala Val Asn Glu Gly Thr Tyr
        355                 360                 365             
Thr Cys Val Val Arg Arg Gln Gln Arg Val Leu Thr Thr Tyr Ser Trp
    370                 375                 380                 
Arg Val Arg Val Arg Gly
385                 390 


<210> 320
<211> 312
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-23 mature

<400> 320
Tyr Thr Leu Thr Pro Ala Arg Leu Arg Trp Asp His Phe Asn Leu Thr
 1               5                  10                  15      
Tyr Arg Ile Leu Ser Phe Pro Arg Asn Leu Leu Ser Pro Arg Glu Thr
            20                  25                  30          
Arg Arg Ala Leu Ala Ala Ala Phe Arg Met Trp Ser Asp Val Ser Pro
        35                  40                  45              
Phe Ser Phe Arg Glu Val Ala Pro Glu Gln Pro Ser Asp Leu Arg Ile
    50                  55                  60                  
Gly Phe Tyr Pro Ile Asn His Thr Asp Cys Leu Val Ser Ala Leu His
65                  70                  75                  80  
His Cys Phe Asp Gly Pro Thr Gly Glu Leu Ala His Ala Phe Phe Pro
                85                  90                  95      
Pro His Gly Gly Ile His Phe Asp Asp Ser Glu Tyr Trp Val Leu Gly
            100                 105                 110         
Pro Thr Arg Tyr Ser Trp Lys Lys Gly Val Trp Leu Thr Asp Leu Val
        115                 120                 125             
His Val Ala Ala His Glu Ile Gly His Ala Leu Gly Leu Met His Ser
    130                 135                 140                 
Gln His Gly Arg Ala Leu Met His Leu Asn Ala Thr Leu Arg Gly Trp
145                 150                 155                 160 
Lys Ala Leu Ser Gln Asp Glu Leu Trp Gly Leu His Arg Leu Tyr Gly
                165                 170                 175     
Cys Leu Asp Arg Leu Phe Val Cys Ala Ser Trp Ala Arg Arg Gly Phe
            180                 185                 190         
Cys Asp Ala Arg Arg Arg Leu Met Lys Arg Leu Cys Pro Ser Ser Cys
        195                 200                 205             
Asp Phe Cys Tyr Glu Phe Pro Phe Pro Thr Val Ala Thr Thr Pro Pro
    210                 215                 220                 
Pro Pro Arg Thr Lys Thr Arg Leu Val Pro Glu Gly Arg Asn Val Thr
225                 230                 235                 240 
Phe Arg Cys Gly Gln Lys Ile Leu His Lys Lys Gly Lys Val Tyr Trp
                245                 250                 255     
Tyr Lys Asp Gln Glu Pro Leu Glu Phe Ser Tyr Pro Gly Tyr Leu Ala
            260                 265                 270         
Leu Gly Glu Ala His Leu Ser Ile Ile Ala Asn Ala Val Asn Glu Gly
        275                 280                 285             
Thr Tyr Thr Cys Val Val Arg Arg Gln Gln Arg Val Leu Thr Thr Tyr
    290                 295                 300                 
Ser Trp Arg Val Arg Val Arg Gly
305                 310         


<210> 321
<211> 1647
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-27

<400> 321
gcttcagctg aagaaagaga ggaatgaagc gccttctgct tctgtttttg ttctttataa 60
cattttcttc tgcatttccc ttagtccgga tgacggaaaa tgaagaaaat atgcaactgg 120
ctcaggcata tctcaaccag ttctactctc ttgaaataga agggaatcat cttgttcaaa 180
gcaagaatag gagtctcata gatgacaaaa ttcgggaaat gcaagcattt tttggattga 240
cagtgactgg aaaactggac tcaaacaccc ttgagatcat gaagacaccc aggtgtgggg 300
tgcctgatgt gggccagtat ggctacaccc tccctgggtg gagaaaatac aacctcacct 360
acagaataat aaactatact ccggatatgg cacgagctgc tgtggatgag gctatccaag 420
aaggtttaga agtgtggagc aaagtcactc cactaaaatt caccaagatt tcaaagggga 480
ttgcagacat catgattgcc tttaggactc gagtccatgg tcggtgtcct cgctattttg 540
atggtccctt gggagtgctt ggccatgcct ttcctcctgg tccgggtctg ggtggtgaca 600
ctcattttga tgaggatgaa aactggacca aggatggagc aggattcaac ttgtttcttg 660
tggctgctca tgaatttggt catgcactgg ggctctctca ctccaatgat caaacagcct 720
tgatgttccc aaattatgtc tccctggatc ccagaaaata cccactttct caggatgata 780
tcaatggaat ccagtccatc tatggaggtc tgcctaagga acctgctaag ccaaaggaac 840
ccactatacc ccatgcctgt gaccctgact tgacttttga cgctatcaca actttccgca 900
gagaagtaat gttctttaaa ggcaggcacc tatggaggat ctattatgat atcacggatg 960
ttgagtttga attaattgct tcattctggc catctctgcc agctgatctg caagctgcat 1020
acgagaaccc cagagataag attctggttt ttaaagatga aaacttctgg atgatcagag 1080
gatatgctgt cttgccagat tatcccaaat ccatccatac attaggtttt ccaggacgtg 1140
tgaagaaaat agatgcagcc gtctgtgata agaccacaag aaaaacctac ttctttgtgg 1200
gcatttggtg ctggaggttt gatgaaatga cccaaaccat ggacaaaggg ttcccgcaga 1260
gagtggtaaa acactttcct ggaatcagta tccgtgttga tgctgctttc cagtacaaag 1320
gattcttctt tttcagccgt ggatcaaagc aatttgaata cgacattaag acaaagaata 1380
ttacccgaat catgagaact aatacttggt ttcaatgcaa agaaccaaag aactcctcat 1440
ttggttttga tatcaacaag gaaaaagcac attcaggagg cataaagata ttgtatcata 1500
agagtttaag cttgtttatt tttggtattg ttcatttgct gaaaaacact tctatttatc 1560
aataaattca tagacctaaa ataaacctca acaggtcttt taatataaat tctgcttcaa 1620
aatagaataa aaccattctt taacaac                                     1647

<210> 322
<211> 513
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-27 precursor

<400> 322
Met Lys Arg Leu Leu Leu Leu Phe Leu Phe Phe Ile Thr Phe Ser Ser
 1               5                  10                  15      
Ala Phe Pro Leu Val Arg Met Met Glu Asn Glu Glu Asn Val Gln Leu
            20                  25                  30          
Ala Gln Ala Tyr Leu Asn Gln Phe Tyr Ser Leu Glu Ile Glu Gly Asn
        35                  40                  45              
His Leu Val Gln Ser Lys Asn Arg Ser Leu Ile Asp Asp Lys Ile Arg
    50                  55                  60                  
Glu Met Gln Ala Phe Phe Gly Leu Thr Val Thr Gly Lys Leu Asp Ser
65                  70                  75                  80  
Asn Thr Leu Glu Ile Met Lys Thr Pro Arg Cys Gly Val Pro Asp Val
                85                  90                  95      
Gly Gln Tyr Gly Tyr Thr Leu Pro Gly Trp Arg Lys Tyr Asn Leu Thr
            100                 105                 110         
Tyr Arg Ile Ile Asn Tyr Thr Pro Asp Met Ala Arg Ala Ala Val Asp
        115                 120                 125             
Glu Ala Ile Gln Glu Gly Leu Glu Val Trp Ser Lys Val Thr Pro Leu
    130                 135                 140                 
Lys Phe Thr Lys Ile Ser Lys Gly Ile Ala Asp Ile Met Ile Ala Phe
145                 150                 155                 160 
Arg Thr Arg Val His Gly Arg Cys Pro Arg Tyr Phe Asp Gly Pro Leu
                165                 170                 175     
Gly Val Leu Gly His Ala Phe Pro Pro Gly Pro Gly Leu Gly Gly Asp
            180                 185                 190         
Thr His Phe Asp Glu Asp Glu Asn Trp Thr Lys Asp Gly Ala Gly Phe
        195                 200                 205             
Asn Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ala Leu Gly Leu
    210                 215                 220                 
Ser His Ser Asn Asp Gln Thr Ala Leu Met Phe Pro Asn Tyr Val Ser
225                 230                 235                 240 
Leu Asp Pro Arg Lys Tyr Pro Leu Ser Gln Asp Asp Ile Asn Gly Ile
                245                 250                 255     
Gln Ser Ile Tyr Gly Gly Leu Pro Lys Glu Pro Ala Lys Pro Lys Glu
            260                 265                 270         
Pro Thr Ile Pro His Ala Cys Asp Pro Asp Leu Thr Phe Asp Ala Ile
        275                 280                 285             
Thr Thr Phe Arg Arg Glu Val Met Phe Phe Lys Gly Arg His Leu Trp
    290                 295                 300                 
Arg Ile Tyr Tyr Asp Ile Thr Asp Val Glu Phe Glu Leu Ile Ala Ser
305                 310                 315                 320 
Phe Trp Pro Ser Leu Pro Ala Asp Leu Gln Ala Ala Tyr Glu Asn Pro
                325                 330                 335     
Arg Asp Lys Ile Leu Val Phe Lys Asp Glu Asn Phe Trp Met Ile Arg
            340                 345                 350         
Gly Tyr Ala Val Leu Pro Asp Tyr Pro Lys Ser Ile His Thr Leu Gly
        355                 360                 365             
Phe Pro Gly Arg Val Lys Lys Ile Asp Ala Ala Val Cys Asp Lys Thr
    370                 375                 380                 
Thr Arg Lys Thr Tyr Phe Phe Val Gly Ile Trp Cys Trp Arg Phe Asp
385                 390                 395                 400 
Glu Met Thr Gln Thr Met Asp Lys Gly Phe Pro Gln Arg Val Val Lys
                405                 410                 415     
His Phe Pro Gly Ile Ser Ile Arg Val Asp Ala Ala Phe Gln Tyr Lys
            420                 425                 430         
Gly Phe Phe Phe Phe Ser Arg Gly Ser Lys Gln Phe Glu Tyr Asp Ile
        435                 440                 445             
Lys Thr Lys Asn Ile Thr Arg Ile Met Arg Thr Asn Thr Trp Phe Gln
    450                 455                 460                 
Cys Lys Glu Pro Lys Asn Ser Ser Phe Gly Phe Asp Ile Asn Lys Glu
465                 470                 475                 480 
Lys Ala His Ser Gly Gly Ile Lys Ile Leu Tyr His Lys Ser Leu Ser
                485                 490                 495     
Leu Phe Ile Phe Gly Ile Val His Leu Leu Lys Asn Thr Ser Ile Tyr
            500                 505                 510         
Gln
    


<210> 323
<211> 415
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-27 mature

<400> 323
Tyr Gly Tyr Thr Leu Pro Gly Trp Arg Lys Tyr Asn Leu Thr Tyr Arg
 1               5                  10                  15      
Ile Ile Asn Tyr Thr Pro Asp Met Ala Arg Ala Ala Val Asp Glu Ala
            20                  25                  30          
Ile Gln Glu Gly Leu Glu Val Trp Ser Lys Val Thr Pro Leu Lys Phe
        35                  40                  45              
Thr Lys Ile Ser Lys Gly Ile Ala Asp Ile Met Ile Ala Phe Arg Thr
    50                  55                  60                  
Arg Val His Gly Arg Cys Pro Arg Tyr Phe Asp Gly Pro Leu Gly Val
65                  70                  75                  80  
Leu Gly His Ala Phe Pro Pro Gly Pro Gly Leu Gly Gly Asp Thr His
                85                  90                  95      
Phe Asp Glu Asp Glu Asn Trp Thr Lys Asp Gly Ala Gly Phe Asn Leu
            100                 105                 110         
Phe Leu Val Ala Ala His Glu Phe Gly His Ala Leu Gly Leu Ser His
        115                 120                 125             
Ser Asn Asp Gln Thr Ala Leu Met Phe Pro Asn Tyr Val Ser Leu Asp
    130                 135                 140                 
Pro Arg Lys Tyr Pro Leu Ser Gln Asp Asp Ile Asn Gly Ile Gln Ser
145                 150                 155                 160 
Ile Tyr Gly Gly Leu Pro Lys Glu Pro Ala Lys Pro Lys Glu Pro Thr
                165                 170                 175     
Ile Pro His Ala Cys Asp Pro Asp Leu Thr Phe Asp Ala Ile Thr Thr
            180                 185                 190         
Phe Arg Arg Glu Val Met Phe Phe Lys Gly Arg His Leu Trp Arg Ile
        195                 200                 205             
Tyr Tyr Asp Ile Thr Asp Val Glu Phe Glu Leu Ile Ala Ser Phe Trp
    210                 215                 220                 
Pro Ser Leu Pro Ala Asp Leu Gln Ala Ala Tyr Glu Asn Pro Arg Asp
225                 230                 235                 240 
Lys Ile Leu Val Phe Lys Asp Glu Asn Phe Trp Met Ile Arg Gly Tyr
                245                 250                 255     
Ala Val Leu Pro Asp Tyr Pro Lys Ser Ile His Thr Leu Gly Phe Pro
            260                 265                 270         
Gly Arg Val Lys Lys Ile Asp Ala Ala Val Cys Asp Lys Thr Thr Arg
        275                 280                 285             
Lys Thr Tyr Phe Phe Val Gly Ile Trp Cys Trp Arg Phe Asp Glu Met
    290                 295                 300                 
Thr Gln Thr Met Asp Lys Gly Phe Pro Gln Arg Val Val Lys His Phe
305                 310                 315                 320 
Pro Gly Ile Ser Ile Arg Val Asp Ala Ala Phe Gln Tyr Lys Gly Phe
                325                 330                 335     
Phe Phe Phe Ser Arg Gly Ser Lys Gln Phe Glu Tyr Asp Ile Lys Thr
            340                 345                 350         
Lys Asn Ile Thr Arg Ile Met Arg Thr Asn Thr Trp Phe Gln Cys Lys
        355                 360                 365             
Glu Pro Lys Asn Ser Ser Phe Gly Phe Asp Ile Asn Lys Glu Lys Ala
    370                 375                 380                 
His Ser Gly Gly Ile Lys Ile Leu Tyr His Lys Ser Leu Ser Leu Phe
385                 390                 395                 400 
Ile Phe Gly Ile Val His Leu Leu Lys Asn Thr Ser Ile Tyr Gln
                405                 410                 415 


<210> 324
<211> 2480
<212> DNA
<213> Homo sapiens

<220> 
<223> MMP-28

<400> 324
tccctcggtc cccggggccg gcggacccgc gggcaggcac tgcccgggct ggacgacgtc 60
tggccggctc ccggcgaagg gcagcggagg agcggcccag agcgcgcagc tagggcactg 120
gcgaaacccc gggacagtcc ctctccgtgc gggggcggcg cagagcagtc ccatccccgg 180
ggtcccgggc gcggctgact gccggctggt tccctgcgcg cagtagctcc ccgagccggg 240
ctgcaccgga ggcggcgaga tggtcgcgcg cgtcggcctc ctgctgcgcg ccctgcagct 300
gctactgtgg ggccacctgg acgcccagcc cgcggagcgc ggaggccagg agctgcgcaa 360
ggaggcggag gcattcctag agaagtacgg atacctcaat gaacaggtcc ccaaagctcc 420
cacctccact cgattcagcg atgccatcag agcgtttcag tgggtgtccc agctacctgt 480
cagcggcgtg ttggaccgcg ccaccctgcg ccagatgact cgtccccgct gcggggttac 540
agataccaac agttatgcgg cctgggctga gaggatcagt gacttgtttg ctagacaccg 600
gaccaaaatg aggcgtaaga aacgctttgc aaagcaaggt aacaaatggt acaagcagca 660
cctctcctac cgcctggtga actggcctga gcatctgccg gagccggcag ttcggggcgc 720
cgtgcgcgcc gccttccagt tgtggagcaa cgtctcagcg ctggagttct gggaggcccc 780
agccacaggc cccgctgaca tccggctcac cttcttccaa ggggaccaca acgatgggct 840
gggcaatgcc tttgatggcc cagggggcgc cctggcgcac gccttcctgc cccgccgcgg 900
cgaagcgcac ttcgaccaag atgagcgctg gtccctgagc cgccgccgcg ggcgcaacct 960
gttcgtggtg ctggcgcacg agatcggtca cacgcttggc ctcacccact cgcccgcgcc 1020
gcgcgcgctc atggcgccct actacaagag gctgggccgc gacgcgctgc tcagctggga 1080
cgacgtgctg gccgtgcaga gcctgtatgg gaagccccta gggggctcag tggccgtcca 1140
gctcccagga aagctgttca ctgactttga gacctgggac tcctacagcc cccaaggaag 1200
gcgccctgaa acgcagggcc ctaaatactg ccactcttcc ttcgatgcca tcactgtaga 1260
caggcaacag caactgtaca tttttaaagg gagccatttc tgggaggtgg cagctgatgg 1320
caacgtctca gagccccgtc cactgcagga aagatgggtc gggctgcccc ccaacattga 1380
ggctgcggca gtgtcattga atgatggaga tttctacttc ttcaaagggg gtcgatgctg 1440
gaggttccgg ggccccaagc cagtgtgggg tctcccacag ctgtgccggg cagggggcct 1500
gccccgccat cctgacgccg ccctcttctt ccctcctctg cgccgcctca tcctcttcaa 1560
gggtgcccgc tactacgtgc tggcccgagg gggactgcaa gtggagccct actacccccg 1620
aagtctgcag gactggggag gcatccctga ggaggtcagc ggcgccctgc cgaggcccga 1680
tggctccatc atcttcttcc gagatgaccg ctactggcgc ctcgaccagg ccaaactgca 1740
ggcaaccacc tcgggccgct gggccaccga gctgccctgg atgggctgct ggcatgccaa 1800
ctcggggagc gccctgttct gaaggcacct cctcacctca gaaactggtg gtgctctcag 1860
ggcaaaatca tgttccccac ccccggggca gaacccctct tagaagcctc tgagtccctc 1920
tgcagaagac cgggcagcaa agcctccatc tggaagtctg tctgcctttg ttccttgaag 1980
aatgcagcat tgtctttgtc tgtccccacc acatggaggt gggggtggga tcaatcttag 2040
gaaaagcaaa aaagggtccc agatcccttg gccctttcct ccgaggactt ctatcctccc 2100
caggcctttg tttcttcggc taaaggtaca gttcctttca agaggtaaca gcactgggat 2160
ccaagcaggg ggatgaaaaa ctcagcagag aaattcgaga ccattttgca agactgtgcc 2220
cttctcctca ggaccccctg gctcagttct tgaaaaacgg tgtcatattt agtcagaggc 2280
cccaccccca ggaagcatgg atggggatga aggcacaggc gtctccaacc tcagaggccc 2340
tttgtggggt caggacacag agtgggaggg agactgatgc aggcctacca gtccctggct 2400
ttttgtctgg ggctggaata aagaggtgcc ttcagctggt gggccgagag gcaggaagca 2460
gccttaaaaa aaaaaaaaaa                                             2480

<210> 325
<211> 520
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-28 precursor

<400> 325
Met Val Ala Arg Val Gly Leu Leu Leu Arg Ala Leu Gln Leu Leu Leu
 1               5                  10                  15      
Trp Gly His Leu Asp Ala Gln Pro Ala Glu Arg Gly Gly Gln Glu Leu
            20                  25                  30          
Arg Lys Glu Ala Glu Ala Phe Leu Glu Lys Tyr Gly Tyr Leu Asn Glu
        35                  40                  45              
Gln Val Pro Lys Ala Pro Thr Ser Thr Arg Phe Ser Asp Ala Ile Arg
    50                  55                  60                  
Ala Phe Gln Trp Val Ser Gln Leu Pro Val Ser Gly Val Leu Asp Arg
65                  70                  75                  80  
Ala Thr Leu Arg Gln Met Thr Arg Pro Arg Cys Gly Val Thr Asp Thr
                85                  90                  95      
Asn Ser Tyr Ala Ala Trp Ala Glu Arg Ile Ser Asp Leu Phe Ala Arg
            100                 105                 110         
His Arg Thr Lys Met Arg Arg Lys Lys Arg Phe Ala Lys Gln Gly Asn
        115                 120                 125             
Lys Trp Tyr Lys Gln His Leu Ser Tyr Arg Leu Val Asn Trp Pro Glu
    130                 135                 140                 
His Leu Pro Glu Pro Ala Val Arg Gly Ala Val Arg Ala Ala Phe Gln
145                 150                 155                 160 
Leu Trp Ser Asn Val Ser Ala Leu Glu Phe Trp Glu Ala Pro Ala Thr
                165                 170                 175     
Gly Pro Ala Asp Ile Arg Leu Thr Phe Phe Gln Gly Asp His Asn Asp
            180                 185                 190         
Gly Leu Gly Asn Ala Phe Asp Gly Pro Gly Gly Ala Leu Ala His Ala
        195                 200                 205             
Phe Leu Pro Arg Arg Gly Glu Ala His Phe Asp Gln Asp Glu Arg Trp
    210                 215                 220                 
Ser Leu Ser Arg Arg Arg Gly Arg Asn Leu Phe Val Val Leu Ala His
225                 230                 235                 240 
Glu Ile Gly His Thr Leu Gly Leu Thr His Ser Pro Ala Pro Arg Ala
                245                 250                 255     
Leu Met Ala Pro Tyr Tyr Lys Arg Leu Gly Arg Asp Ala Leu Leu Ser
            260                 265                 270         
Trp Asp Asp Val Leu Ala Val Gln Ser Leu Tyr Gly Lys Pro Leu Gly
        275                 280                 285             
Gly Ser Val Ala Val Gln Leu Pro Gly Lys Leu Phe Thr Asp Phe Glu
    290                 295                 300                 
Thr Trp Asp Ser Tyr Ser Pro Gln Gly Arg Arg Pro Glu Thr Gln Gly
305                 310                 315                 320 
Pro Lys Tyr Cys His Ser Ser Phe Asp Ala Ile Thr Val Asp Arg Gln
                325                 330                 335     
Gln Gln Leu Tyr Ile Phe Lys Gly Ser His Phe Trp Glu Val Ala Ala
            340                 345                 350         
Asp Gly Asn Val Ser Glu Pro Arg Pro Leu Gln Glu Arg Trp Val Gly
        355                 360                 365             
Leu Pro Pro Asn Ile Glu Ala Ala Ala Val Ser Leu Asn Asp Gly Asp
    370                 375                 380                 
Phe Tyr Phe Phe Lys Gly Gly Arg Cys Trp Arg Phe Arg Gly Pro Lys
385                 390                 395                 400 
Pro Val Trp Gly Leu Pro Gln Leu Cys Arg Ala Gly Gly Leu Pro Arg
                405                 410                 415     
His Pro Asp Ala Ala Leu Phe Phe Pro Pro Leu Arg Arg Leu Ile Leu
            420                 425                 430         
Phe Lys Gly Ala Arg Tyr Tyr Val Leu Ala Arg Gly Gly Leu Gln Val
        435                 440                 445             
Glu Pro Tyr Tyr Pro Arg Ser Leu Gln Asp Trp Gly Gly Ile Pro Glu
    450                 455                 460                 
Glu Val Ser Gly Ala Leu Pro Arg Pro Asp Gly Ser Ile Ile Phe Phe
465                 470                 475                 480 
Arg Asp Asp Arg Tyr Trp Arg Leu Asp Gln Ala Lys Leu Gln Ala Thr
                485                 490                 495     
Thr Ser Gly Arg Trp Ala Thr Glu Leu Pro Trp Met Gly Cys Trp His
            500                 505                 510         
Ala Asn Ser Gly Ser Ala Leu Phe
        515                 520 


<210> 326
<211> 398
<212> PRT
<213> Homo sapiens

<220> 
<223> MMP-28 mature

<400> 326
Phe Ala Lys Gln Gly Asn Lys Trp Tyr Lys Gln His Leu Ser Tyr Arg
 1               5                  10                  15      
Leu Val Asn Trp Pro Glu His Leu Pro Glu Pro Ala Val Arg Gly Ala
            20                  25                  30          
Val Arg Ala Ala Phe Gln Leu Trp Ser Asn Val Ser Ala Leu Glu Phe
        35                  40                  45              
Trp Glu Ala Pro Ala Thr Gly Pro Ala Asp Ile Arg Leu Thr Phe Phe
    50                  55                  60                  
Gln Gly Asp His Asn Asp Gly Leu Gly Asn Ala Phe Asp Gly Pro Gly
65                  70                  75                  80  
Gly Ala Leu Ala His Ala Phe Leu Pro Arg Arg Gly Glu Ala His Phe
                85                  90                  95      
Asp Gln Asp Glu Arg Trp Ser Leu Ser Arg Arg Arg Gly Arg Asn Leu
            100                 105                 110         
Phe Val Val Leu Ala His Glu Ile Gly His Thr Leu Gly Leu Thr His
        115                 120                 125             
Ser Pro Ala Pro Arg Ala Leu Met Ala Pro Tyr Tyr Lys Arg Leu Gly
    130                 135                 140                 
Arg Asp Ala Leu Leu Ser Trp Asp Asp Val Leu Ala Val Gln Ser Leu
145                 150                 155                 160 
Tyr Gly Lys Pro Leu Gly Gly Ser Val Ala Val Gln Leu Pro Gly Lys
                165                 170                 175     
Leu Phe Thr Asp Phe Glu Thr Trp Asp Ser Tyr Ser Pro Gln Gly Arg
            180                 185                 190         
Arg Pro Glu Thr Gln Gly Pro Lys Tyr Cys His Ser Ser Phe Asp Ala
        195                 200                 205             
Ile Thr Val Asp Arg Gln Gln Gln Leu Tyr Ile Phe Lys Gly Ser His
    210                 215                 220                 
Phe Trp Glu Val Ala Ala Asp Gly Asn Val Ser Glu Pro Arg Pro Leu
225                 230                 235                 240 
Gln Glu Arg Trp Val Gly Leu Pro Pro Asn Ile Glu Ala Ala Ala Val
                245                 250                 255     
Ser Leu Asn Asp Gly Asp Phe Tyr Phe Phe Lys Gly Gly Arg Cys Trp
            260                 265                 270         
Arg Phe Arg Gly Pro Lys Pro Val Trp Gly Leu Pro Gln Leu Cys Arg
        275                 280                 285             
Ala Gly Gly Leu Pro Arg His Pro Asp Ala Ala Leu Phe Phe Pro Pro
    290                 295                 300                 
Leu Arg Arg Leu Ile Leu Phe Lys Gly Ala Arg Tyr Tyr Val Leu Ala
305                 310                 315                 320 
Arg Gly Gly Leu Gln Val Glu Pro Tyr Tyr Pro Arg Ser Leu Gln Asp
                325                 330                 335     
Trp Gly Gly Ile Pro Glu Glu Val Ser Gly Ala Leu Pro Arg Pro Asp
            340                 345                 350         
Gly Ser Ile Ile Phe Phe Arg Asp Asp Arg Tyr Trp Arg Leu Asp Gln
        355                 360                 365             
Ala Lys Leu Gln Ala Thr Thr Ser Gly Arg Trp Ala Thr Glu Leu Pro
    370                 375                 380                 
Trp Met Gly Cys Trp His Ala Asn Ser Gly Ser Ala Leu Phe
385                 390                 395             


<210> 327
<211> 450
<212> PRT
<213> Homo sapiens

<220> 
<223> Mature MMP-1 with prodomain

<400> 327
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 328
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant L95K

<400> 328
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Lys Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 329
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant L95I

<400> 329
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Ile Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 330
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D105E

<400> 330
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Glu Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 331
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D105R

<400> 331
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Arg Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 332
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D105N

<400> 332
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asn Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 333
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D105T

<400> 333
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Thr Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 334
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D105S

<400> 334
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Ser Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 335
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D105G

<400> 335
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Gly Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 336
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D105F

<400> 336
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Phe Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 337
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D105W

<400> 337
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Trp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 338
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D105I

<400> 338
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Ile Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 339
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D105L

<400> 339
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Leu Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 340
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D105A

<400> 340
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Ala Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 341
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R150D

<400> 341
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Asp Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 342
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R150H

<400> 342
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His His Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 343
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R150I

<400> 343
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Ile Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 344
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R150V

<400> 344
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Val Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 345
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R150P

<400> 345
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Pro Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 346
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D151G

<400> 346
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Gly Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 347
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant F155L

<400> 347
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Leu Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 348
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant F155A

<400> 348
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Ala Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 349
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D156H

<400> 349
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe His Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 350
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D156K

<400> 350
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Lys Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 351
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D156R

<400> 351
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Arg Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 352
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D156T

<400> 352
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Thr Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 353
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D156M

<400> 353
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Met Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 354
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D156W

<400> 354
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Trp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 355
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D156V

<400> 355
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Val Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 356
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D156L

<400> 356
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Leu Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 357
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D156A

<400> 357
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Ala Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 358
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant G159C

<400> 358
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Cys Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 359
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant G159T

<400> 359
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Thr Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 360
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant G159M

<400> 360
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Met Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 361
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant G159W

<400> 361
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Trp Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 362
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant G159I

<400> 362
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Ile Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 363
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant G159V

<400> 363
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Val Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 364
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant G159L

<400> 364
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Leu Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 365
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant A176F

<400> 365
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Phe
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 366
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant A176W

<400> 366
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Trp
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 367
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D179C

<400> 367
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Cys Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 368
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D179N

<400> 368
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asn Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 369
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D179V

<400> 369
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Val Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 370
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E180D

<400> 370
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Asp Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 371
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E180R

<400> 371
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Arg Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 372
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E180N

<400> 372
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Asn Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 373
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E180T

<400> 373
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Thr Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 374
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E180Y

<400> 374
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Tyr Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 375
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E180S

<400> 375
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Ser Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 376
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E180G

<400> 376
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Gly Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 377
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E180F

<400> 377
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Phe Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 378
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D181K

<400> 378
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Lys Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 379
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D181C

<400> 379
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Cys Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 380
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D181T

<400> 380
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Thr Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 381
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D181G

<400> 381
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Gly Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 382
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D181L

<400> 382
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Leu Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 383
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E182Q

<400> 383
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Gln Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 384
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E182T

<400> 384
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Tyr Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 385
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E182G

<400> 385
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Gly Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 386
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E182M

<400> 386
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Met Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 387
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant T185D

<400> 387
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Asp Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 388
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant T185E

<400> 388
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Glu Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 389
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant T185H

<400> 389
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp His Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 390
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant T185R

<400> 390
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Arg Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 391
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant T185Q

<400> 391
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Gln Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 392
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant T185Y

<400> 392
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Tyr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 393
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant T185G

<400> 393
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Gly Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 394
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant T185V

<400> 394
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 395
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant T185A

<400> 395
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Ala Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 396
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant N187H

<400> 396
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn His Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 397
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant N187K

<400> 397
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Lys Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 398
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant N187R

<400> 398
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Arg Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 399
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant N187C

<400> 399
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Cys Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 400
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant N187G

<400> 400
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Gly Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 401
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant N187F

<400> 401
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Phe Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 402
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant N187M

<400> 402
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Met Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 403
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant N187W

<400> 403
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Trp Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 404
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant N187I

<400> 404
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Ile Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 405
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant N187A

<400> 405
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Ala Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 406
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R195D

<400> 406
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Asp Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 407
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R195C

<400> 407
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Cys Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 408
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R195Q

<400> 408
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Gln Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 409
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R195G

<400> 409
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Gly Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 410
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R195W

<400> 410
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Trp Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 411
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R195V

<400> 411
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Val Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 412
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R195L

<400> 412
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Leu Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 413
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R195A

<400> 413
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Ala Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 414
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant A198G

<400> 414
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Gly His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 415
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant A198M

<400> 415
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Met His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 416
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant A198L

<400> 416
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Leu His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 417
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant G206S

<400> 417
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Ser Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 418
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant G206A

<400> 418
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Ala Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 419
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant S210V

<400> 419
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Val Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 420
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant S210A

<400> 420
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ala Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 421
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant Y218S

<400> 421
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Ser Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 422
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant F223E

<400> 422
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Glu Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 423
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant F223K

<400> 423
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Lys Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 424
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant F223C

<400> 424
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Cys Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 425
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant F223S

<400> 425
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Ser Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 426
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant F223G

<400> 426
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Gly Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 427
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant F223M

<400> 427
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Met Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 428
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant F223A

<400> 428
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Ala Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 429
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant V227D

<400> 429
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Asp Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 430
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant V227E

<400> 430
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Glu Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 431
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant V227H

<400> 431
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp His Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 432
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant V227R

<400> 432
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Arg Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 433
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant V227C

<400> 433
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Cys Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 434
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant V227Q

<400> 434
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Gln Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 435
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant V227S

<400> 435
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Ser Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 436
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant V227G

<400> 436
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Gly Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 437
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant V227W

<400> 437
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Trp Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450  


<210> 438
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant V227L

<400> 438
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Leu Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 439
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant Q228P

<400> 439
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Pro Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 440
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant L229T

<400> 440
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Thr Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 441
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant L229I

<400> 441
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Ile Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450  


<210> 442
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant L229A

<400> 442
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Ala Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 443
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D233E

<400> 443
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Glu Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450  


<210> 444
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant I234E

<400> 444
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Glu Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 445
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant I234Q

<400> 445
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Gln Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 446
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant I234T

<400> 446
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Thr Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 447
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant I234A

<400> 447
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ala Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 448
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant I240C

<400> 448
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Cys
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 449
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant I240S

<400> 449
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ser
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 450
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant I240A

<400> 450
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ala
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 451
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E100R

<400> 451
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Arg Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 452
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E100N

<400> 452
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Asn Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 453
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E100T

<400> 453
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Thr Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 454
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E100S

<400> 454
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Ser Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 455
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E100F

<400> 455
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Phe Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 456
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E100I

<400> 456
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Ile Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 457
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E100V

<400> 457
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 458
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant T103Y

<400> 458
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Tyr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 459
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant S153T

<400> 459
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Thr Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 460
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant G171D

<400> 460
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Asp Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 461
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant G171E

<400> 461
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Glu Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 462
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant G171P

<400> 462
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Pro Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 463
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E190D

<400> 463
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Asp Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 464
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E190Y

<400> 464
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Tyr Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 465
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E190G

<400> 465
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Gly Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 466
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant Y191V

<400> 466
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Val Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 467
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant N192D

<400> 467
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asp
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 468
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant N192H

<400> 468
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr His
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 469
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant N192C

<400> 469
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Cys
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 470
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant N192S

<400> 470
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Ser
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 471
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant H194P

<400> 471
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu Pro Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 472
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant L207R

<400> 472
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Arg Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 473
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant L207G

<400> 473
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Gly Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 474
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant L207I

<400> 474
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Ile Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 475
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant L207V

<400> 475
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Val Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 476
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D212H

<400> 476
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr His Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 477
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D212G

<400> 477
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Gly Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 478
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant A230V

<400> 478
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Val Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 479
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant T84F

<400> 479
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Phe Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 480
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant E85F

<400> 480
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Phe Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 481
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R98D

<400> 481
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Asp Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 482
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant I99Q

<400> 482
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Gln Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 483
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant P104M

<400> 483
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Met Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 484
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant P104A

<400> 484
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Ala Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 485
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant L106C

<400> 485
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Cys Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 486
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant L106S

<400> 486
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Ser Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 487
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant A109H

<400> 487
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg His Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 488
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D110A

<400> 488
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Ala Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 489
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant V111R

<400> 489
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Arg Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 490
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant D112S

<400> 490
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Ser
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 491
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant A118T

<400> 491
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Thr Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 492
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant S123V

<400> 492
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Val Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 493
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant N124D

<400> 493
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asp Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 494
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant T126S

<400> 494
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Ser Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 495
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant G147P

<400> 495
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Pro Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 496
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant N152S

<400> 496
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Ser Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 497
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant N152A

<400> 497
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Ala Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 498
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant P158K

<400> 498
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Lys Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 499
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant P158N

<400> 499
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Asn Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450

 
<210> 500
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant P158T

<400> 500
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Thr Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450
 

<210> 501
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant P158G

<400> 501
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Gly Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 502
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant P170D

<400> 502
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Asp Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 503
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant P170A

<400> 503
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Ala Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 504
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant F178T

<400> 504
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Thr Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 505
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant F178L

<400> 505
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Leu Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 506
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R183S

<400> 506
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Ser Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 507
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R183G

<400> 507
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Gly Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 508
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant F188V

<400> 508
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Val Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 509
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R189N

<400> 509
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Asn Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 510
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R189Q

<400> 510
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Gln Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 511
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant R189T

<400> 511
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Thr Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 512
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant A197C

<400> 512
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Cys Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 513
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant S208R

<400> 513
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Arg
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 514
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant S208L

<400> 514
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Leu
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 515
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant T211L

<400> 515
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Leu Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 516
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant I237N

<400> 516
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Asn Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 517
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant I237W

<400> 517
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Trp Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 518
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant I237W

<400> 518
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Leu Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 519
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant I251S

<400> 519
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ser Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 520
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant I251W

<400> 520
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Trp Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 521
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant Q254S

<400> 521
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Ser Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 522
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant T255H

<400> 522
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln His Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 523
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant P256C

<400> 523
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Cys
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 524
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant P256C

<400> 524
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Thr Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 525
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant P256C

<400> 525
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Pro Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 526
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> MMP-1 variant A258P

<400> 526
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Pro Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 527
<211> 450
<212> PRT
<213> Sus scrofa

<220> 
<223> Pig MMP-1 zymogen

<400> 527
Pro Ala Ala Thr Ser Glu Thr Gln Glu Gln Asp Val Glu Ile Val Gln
 1               5                  10                  15      
Lys Tyr Leu Lys Asn Tyr Tyr Asn Leu Asn Ser Asp Gly Val Pro Val
            20                  25                  30          
Glu Lys Lys Arg Asn Ser Gly Leu Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Gln Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Asn Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Glu
65                  70                  75                  80  
Phe Val Leu Thr Pro Gly Asn Pro Arg Trp Glu Asn Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Ser Arg Glu Asp Val Asp
            100                 105                 110         
Arg Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Ser Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Asp Glu Arg Trp Thr Lys Asn Phe Arg Asp Tyr Asn
            180                 185                 190         
Leu Tyr Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Asn Tyr Ile Tyr Thr
    210                 215                 220                 
Gly Asp Val Gln Leu Ser Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Pro Ser Glu Asn Pro Val Gln Pro Ser Gly Pro Gln Thr Pro
                245                 250                 255     
Gln Val Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Leu Arg
            260                 265                 270         
Gly Glu Leu Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Ser
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Val Pro Asn Gly Leu Gln Ala Ala Tyr Glu Ile Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Arg Gly Gln Asp
                325                 330                 335     
Val Leu Tyr Gly Tyr Pro Lys Asp Ile His Arg Ser Phe Gly Phe Pro
            340                 345                 350         
Ser Thr Val Lys Asn Ile Asp Ala Ala Val Phe Glu Glu Asp Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala His Glu Cys Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Gln Ser Met Asp Thr Gly Tyr Pro Lys Met Ile Ala Glu Glu Phe
385                 390                 395                 400 
Pro Gly Ile Gly Asn Lys Val Asp Ala Val Phe Gln Lys Asp Gly Phe
                405                 410                 415     
Leu Tyr Phe Phe His Gly Thr Arg Gln Tyr Gln Phe Asp Phe Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 528
<211> 450
<212> PRT
<213> Oryctolagus cuniculus

<220> 
<223> Rabbit MMP-1 zymogen

<400> 528
Phe Pro Ala Ala Ser Glu Thr Gln Glu Gln Asp Val Glu Met Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Asn Tyr Tyr Asn Leu Lys Asp Asp Trp Arg Lys Ile
            20                  25                  30          
Pro Lys Gln Arg Gly Asn Gly Leu Ala Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Met Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Pro Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Ser Arg Ala Asp Val Asp
            100                 105                 110         
Asn Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Lys Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Glu Gly
145                 150                 155                 160 
Gln Leu Ala His Ala Phe Gln Pro Gly Leu Gly Ile Gly Gly Asp Val
                165                 170                 175     
His Phe Asp Glu Asp Asp Arg Trp Thr Lys Asp Phe Arg Asn Tyr Asn
            180                 185                 190         
Leu Tyr Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Asn Tyr Met Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Pro Ser Gln Asn Pro Ser Gln Pro Val Gly Pro Gln Thr Pro
                245                 250                 255     
Lys Val Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Ile Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Ala Asn Pro
        275                 280                 285             
Tyr Tyr Ser Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro His
    290                 295                 300                 
Leu Pro Asn Gly Leu Gln Ala Ala Tyr Glu Val Ala His Arg Asp Glu
305                 310                 315                 320 
Ile Leu Phe Phe Lys Gly Asn Lys Tyr Trp Thr Val Gln Gly Gln Asn
                325                 330                 335     
Glu Leu Pro Gly Tyr Pro Lys Asp Ile His Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Ser Val Asn His Ile Asp Ala Ala Val Ser Glu Glu Asp Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Arg Ser Met Asp Ala Gly Tyr Pro Lys Met Ile Glu Tyr Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly Asn Lys Val Asp Ala Val Phe Lys Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 


<210> 529
<211> 451
<212> PRT
<213> Bos taurus

<220> 
<223> Cow MMP-1

<400> 529
Phe Pro Ala Ala Thr Ser Glu Thr Gln Glu Gln Asp Val Glu Thr Val
 1               5                  10                  15      
Lys Lys Tyr Leu Glu Asn Tyr Tyr Asn Leu Asn Ser Asn Gly Lys Lys
            20                  25                  30          
Val Glu Arg Gln Arg Asn Gly Gly Leu Ile Thr Glu Lys Leu Lys Gln
        35                  40                  45              
Met Gln Lys Phe Phe Gly Leu Arg Val Thr Gly Lys Pro Asp Ala Glu
    50                  55                  60                  
Thr Leu Asn Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala
65                  70                  75                  80  
Pro Phe Val Leu Thr Pro Gly Lys Ser Cys Trp Glu Asn Thr Asn Leu
                85                  90                  95      
Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Ser Arg Ala Asp Val
            100                 105                 110         
Asp Gln Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro
        115                 120                 125             
Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser
    130                 135                 140                 
Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly
145                 150                 155                 160 
Gly Asn Leu Ala His Ala Phe Gln Pro Gly Ala Gly Ile Gly Gly Asp
                165                 170                 175     
Ala His Phe Asp Asp Asp Glu Trp Trp Thr Ser Asn Phe Gln Asp Tyr
            180                 185                 190         
Asn Leu Tyr Arg Val Ala Ala His Glu Phe Gly His Ser Leu Gly Leu
        195                 200                 205             
Ala His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe
    210                 215                 220                 
Ser Gly Asp Val Gln Leu Ser Gln Asp Asp Ile Asp Gly Ile Gln Ala
225                 230                 235                 240 
Ile Tyr Gly Pro Ser Gln Asn Pro Thr Gln Pro Val Gly Pro Gln Thr
                245                 250                 255     
Pro Glu Val Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile
            260                 265                 270         
Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn
        275                 280                 285             
Pro Leu Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro
    290                 295                 300                 
Gln Leu Pro Asn Gly Leu Gln Ala Ala Tyr Glu Val Ala Asp Arg Asp
305                 310                 315                 320 
Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Lys Gly Gln
                325                 330                 335     
Asp Val Leu Arg Gly Tyr Pro Arg Asp Ile Tyr Arg Ser Phe Gly Phe
            340                 345                 350         
Pro Arg Thr Val Lys Ser Ile Asp Ala Ala Val Ser Glu Glu Asp Thr
        355                 360                 365             
Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Cys Trp Arg Tyr Asp Glu
    370                 375                 380                 
Tyr Lys Gln Ser Met Asp Ala Gly Tyr Pro Lys Met Ile Ala Glu Asp
385                 390                 395                 400 
Phe Pro Gly Ile Gly Asn Lys Val Asp Ala Val Phe Gln Lys Gly Gly
                405                 410                 415     
Phe Phe Tyr Phe Phe His Gly Arg Arg Gln Tyr Lys Phe Asp Pro Gln
            420                 425                 430         
Thr Lys Arg Ile Leu Thr Leu Leu Lys Ala Asn Ser Trp Phe Asn Cys
        435                 440                 445             
Arg Lys Asn
    450     


<210> 530
<211> 451
<212> PRT
<213> Equus caballus

<220> 
<223> Horse MMP-1

<400> 530
Phe Pro Thr Val Pro Ser Glu Thr Arg Glu Glu Asp Val Glu Met Val
 1               5                  10                  15      
Gln Lys Tyr Leu Glu Asn Tyr Tyr Asn Leu Lys Ser Asp Gly Glu Gln
            20                  25                  30          
Ile Glu Lys Gln Arg His Arg Ser Pro Val Val Glu Lys Leu Lys Gln
        35                  40                  45              
Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu
    50                  55                  60                  
Thr Leu Asn Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala
65                  70                  75                  80  
Glu Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Asn Thr His Leu
                85                  90                  95      
Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val
            100                 105                 110         
Asp Gln Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Ser Pro
        115                 120                 125             
Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser
    130                 135                 140                 
Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly
145                 150                 155                 160 
Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Arg Ile Gly Gly Asp
                165                 170                 175     
Ala His Phe Asp Glu Asp Glu Thr Trp Thr Ser Asn Phe Arg Asn Tyr
            180                 185                 190         
Asn Leu Tyr Arg Val Ala Ala His Glu Phe Gly His Ser Leu Gly Leu
        195                 200                 205             
Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Asn Tyr Phe Phe
    210                 215                 220                 
Thr Gly Asp Val Gln Leu Ser Gln Asp Asp Ile Asn Gly Ile Gln Ala
225                 230                 235                 240 
Ile Tyr Gly Pro Ser Gln Asn Pro Ile Gln Pro Ile Gly Pro Gln Thr
                245                 250                 255     
Pro Glu Val Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile
            260                 265                 270         
Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Ile Asn
        275                 280                 285             
Pro Tyr Tyr Pro Glu Ala Glu Leu Asn Phe Ile Ser Ile Phe Trp Pro
    290                 295                 300                 
Gln Leu Pro Asn Gly Leu Gln Ala Ala Tyr Glu Val Ser His Arg Asp
305                 310                 315                 320 
Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Lys Gly Gln
                325                 330                 335     
Asp Val Leu Tyr Gly Tyr Pro Lys Asp Ile His Arg Ser Phe Gly Phe
            340                 345                 350         
Pro Ser Thr Val Lys Asn Ile Asp Ala Ala Val Ser Glu Glu Asp Thr
        355                 360                 365             
Gly Lys Thr Tyr Phe Phe Val Ala Asp Lys Tyr Trp Arg Tyr Asp Glu
    370                 375                 380                 
Tyr Lys Arg Ser Met Asp Ala Gly Tyr Pro Lys Met Ile Ala Asp Asp
385                 390                 395                 400 
Phe Pro Gly Ile Gly Asp Lys Val Asp Ala Val Phe Gln Lys Asp Gly
                405                 410                 415     
Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys
            420                 425                 430         
Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys
        435                 440                 445             
Arg Lys Asn
    450     


<210> 531
<211> 447
<212> PRT
<213> Rattus norvegicus

<220> 
<223> Rat MMP-1a

<400> 531
Phe Pro Val Phe Gln Asp Gly Ala Arg Gln Asn Val Glu Thr Val Trp
 1               5                  10                  15      
Lys Tyr Leu Glu Asn Tyr Tyr Asn Leu Gly Glu Asp Val Gln Ala Lys
            20                  25                  30          
Asn Val Asp Ala Lys Glu Val Met Ala Glu Lys Leu Arg Gln Met Gln
        35                  40                  45              
Gln Leu Phe Gly Leu Lys Val Thr Gly Asn Ser Asn Ser Glu Thr Leu
    50                  55                  60                  
Ser Ala Met Arg Lys Pro Arg Cys Gly Val Pro Asp Val Ala Pro Tyr
65                  70                  75                  80  
Ala Ile Thr His Asn Asn Pro Arg Trp Thr Lys Thr His Leu Thr Tyr
                85                  90                  95      
Ser Ile Leu Asn Tyr Thr Pro Tyr Leu Pro Lys Glu Val Ile Glu Asn
            100                 105                 110         
Ala Ile Glu Arg Ala Phe Lys Val Trp Ser Asp Val Thr Pro Leu Thr
        115                 120                 125             
Phe Glu Arg Val Phe Glu Glu Glu Gly Asp Ile Val Phe Ala Phe Tyr
    130                 135                 140                 
Arg Gly Asp His Ser Asp Asn Asn Pro Phe Asp Gly Pro Glu Tyr Gly
145                 150                 155                 160 
Leu Ala His Thr Phe Pro Pro Gly Pro Arg Leu Gly Gly Asp Val His
                165                 170                 175     
Tyr Asp Leu Asp Glu Thr Trp Thr Asp Asn Ser Asp Asn Phe Asn Leu
            180                 185                 190         
Phe Tyr Val Thr Ala His Glu Leu Gly His Ser Leu Gly Leu Thr His
        195                 200                 205             
Ser Arg Asp Val Gly Ala Leu Met Phe Pro Ser Tyr Thr Trp Tyr Thr
    210                 215                 220                 
Glu Asp Phe Val Leu Asn Gln Glu Asp Ile Asn Arg Ile Gln Ala Leu
225                 230                 235                 240 
Tyr Gly Pro Ser Pro Asn Pro Ile Gln Pro Thr Gly Ala Thr Thr Pro
                245                 250                 255     
His Pro Cys Asp Gly Asp Leu Thr Phe Asp Ala Ile Thr Thr Phe Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Gly Arg Phe Tyr Ile Arg Val Asn Lys
        275                 280                 285             
Phe Met Pro Glu Ala Glu Leu Asn Leu Ile Gly Ile Ile Trp Pro Asn
    290                 295                 300                 
Leu Pro Gly Lys Leu Asp Ala Ala Tyr Glu Val Ser Met Ile Asp Gln
305                 310                 315                 320 
Val Arg Tyr Phe Lys Gly Asn Lys Val Trp Val Val Arg Glu His Thr
                325                 330                 335     
Val Leu Arg Gly Phe Pro Thr Asp Ile His Ser Phe Phe Gly Phe Pro
            340                 345                 350         
Ser Ser Val Thr His Ile Asp Ala Ala Val Cys Glu Glu Glu Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Asp Asn Met Tyr Trp Arg Tyr Asp Glu Asn
    370                 375                 380                 
Thr Gln Ser Met Asp Pro Gly Tyr Pro Arg Leu Thr Ala Glu Asp Phe
385                 390                 395                 400 
Pro Gly Ile Asp Asp Lys Val Asp Asp Val Phe Gln Lys Gly Glu Asn
                405                 410                 415     
Phe Tyr Phe Phe His Gln Ser Val Gln Arg Arg Phe Ser Leu Arg Ile
            420                 425                 430         
Arg Arg Val Asp Asp Ser Arg Asp Ser Ser Thr Trp Phe Asn Cys
        435                 440                 445         


<210> 532
<211> 447
<212> PRT
<213> Mus musculus

<220> 
<223> Mouse MMP-1a

<400> 532
Phe Pro Val Phe His Asn Gly Asp Arg Gln Asn Val Glu Thr Val Trp
 1               5                  10                  15      
Lys Tyr Leu Glu Asn Tyr Tyr Asn Leu Gly Lys Asn Met Gln Ala Lys
            20                  25                  30          
Asn Val Asn Gly Lys Glu Met Met Ala Glu Lys Leu Arg Gln Met Gln
        35                  40                  45              
Gln Leu Phe Gly Leu Lys Val Thr Gly Asn Ser Asp Pro Glu Thr Leu
    50                  55                  60                  
Arg Ala Met Lys Lys Pro Arg Cys Gly Val Pro Asp Val Ala Pro Tyr
65                  70                  75                  80  
Ala Ile Thr His Asn Asn Pro Arg Trp Thr Lys Thr His Leu Thr Tyr
                85                  90                  95      
Ser Ile Leu Asn Tyr Thr Pro Tyr Leu Pro Lys Ala Val Val Glu Asp
            100                 105                 110         
Ala Ile Ala Arg Ala Phe Arg Val Trp Ser Asp Val Thr Pro Leu Thr
        115                 120                 125             
Phe Gln Arg Val Phe Glu Glu Glu Gly Asp Ile Val Leu Ser Phe His
    130                 135                 140                 
Arg Gly Asp His Gly Asp Asn Asn Pro Phe Asp Gly Pro Asn Tyr Lys
145                 150                 155                 160 
Leu Ala His Thr Phe Gln Pro Gly Pro Gly Leu Gly Gly Asp Val His
                165                 170                 175     
Tyr Asp Leu Asp Glu Thr Trp Thr Asn Ser Ser Glu Asn Phe Asn Leu
            180                 185                 190         
Phe Tyr Val Thr Ala His Glu Leu Gly His Ser Leu Gly Leu Thr His
        195                 200                 205             
Ser Ser Asp Ile Gly Ala Leu Met Phe Pro Ser Tyr Thr Trp Tyr Thr
    210                 215                 220                 
Glu Asp Phe Val Leu Asn Gln Asp Asp Ile Asn Arg Ile Gln Asp Leu
225                 230                 235                 240 
Tyr Gly Pro Ser Pro Asn Pro Ile Gln Pro Thr Gly Ala Thr Thr Pro
                245                 250                 255     
His Pro Cys Asn Gly Asp Leu Thr Phe Asp Ala Ile Thr Thr Phe Arg
            260                 265                 270         
Gly Glu Val Phe Phe Phe Lys Gly Arg Phe Tyr Ile Arg Val Asn Arg
        275                 280                 285             
Phe Met Pro Glu Pro Glu Leu Asn Leu Ile Gly Ile Leu Trp Pro Asn
    290                 295                 300                 
Leu Pro Val Lys Leu Asp Ala Ala Tyr Glu Ala Ser Met Ile Asp Gln
305                 310                 315                 320 
Val Arg Tyr Phe Lys Gly Ser Lys Val Trp Ala Val Gln Glu Gln Ser
                325                 330                 335     
Val Leu Arg Gly Phe Pro Arg Asp Ile His Ser Phe Phe Gly Phe Pro
            340                 345                 350         
Ser Asn Val Thr His Ile Asp Ala Ala Val Cys Glu Glu Glu Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Val Asp His Met Tyr Trp Arg Tyr Asp Glu Asn
    370                 375                 380                 
Thr Gln Ser Met Asp Pro Gly Tyr Pro Arg Leu Thr Ala Glu Asp Phe
385                 390                 395                 400 
Pro Gly Ile Asp Asp Lys Val Asp Asp Val Phe Gln Lys Gly Glu Asn
                405                 410                 415     
Phe Tyr Phe Phe His Gln Ser Val Gln His Arg Phe Asn Leu Gln Ile
            420                 425                 430         
Arg Arg Val Asp Asp Ser Arg Asp Ser Ser Thr Trp Phe Asn Cys
        435                 440                 445         


<210> 533
<211> 5369
<212> DNA
<213> Artificial Sequence

<220> 
<223> pET303CTHis vector

<400> 533
gatctcgatc ccgcgaaatt aatacgactc actatagggg aattgtgagc ggataacaat 60
tcccctctag taataatttt gtttaacttt aagaaggagg tctagaatgc atctcgagca 120
ccaccaccac caccactgag atccggctgc taacaaagcc cgaaaggaag ctgagttggc 180
tgctgccacc gctgagcaat aactagcata accccttggg gcctctaaac gggtcttgag 240
gggttttttg ctgaaaggag gaactatatc cggattggcg aatgggacgc gccctgtagc 300
ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc 360
gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt 420
ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac 480
ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc gccctgatag 540
acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa 600
actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg gattttgccg 660
atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattttaac 720
aaaatattaa cgtttacaat ttcaggtggc acttttcggg gaaatgtgcg cggaacccct 780
atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga 840
taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc 900
cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg 960
aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc 1020
aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact 1080
tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc 1140
ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag 1200
catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat 1260
aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt 1320
ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa 1380
gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac aacgttgcgc 1440
aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg 1500
gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt 1560
gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca 1620
gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat 1680
gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca 1740
gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg 1800
atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg 1860
ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt 1920
ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg 1980
ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata 2040
ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca 2100
ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag 2160
tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc 2220
tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga 2280
tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg 2340
tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac 2400
gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg 2460
tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg 2520
ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct 2580
gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc 2640
gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc tgatgcggta ttttctcctt 2700
acgcatctgt gcggtatttc acaccgcaat ggtgcactct cagtacaatc tgctctgatg 2760
ccgcatagtt aagccagtat acactccgct atcgctacgt gactgggtca tggctgcgcc 2820
ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc 2880
ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt caccgtcatc 2940
accgaaacgc gcgaggcagc tgcggtaaag ctcatcagcg tggtcgtgaa gcgattcaca 3000
gatgtctgcc tgttcatccg cgtccagctc gttgagtttc tccagaagcg ttaatgtctg 3060
gcttctgata aagcgggcca tgttaagggc ggttttttcc tgtttggtca ctgatgcctc 3120
cgtgtaaggg ggatttctgt tcatgggggt aatgataccg atgaaacgag agaggatgct 3180
cacgatacgg gttactgatg atgaacatgc ccggttactg gaacgttgtg agggtaaaca 3240
actggcggta tggatgcggc gggaccagag aaaaatcact cagggtcaat gccagcgctt 3300
cgttaataca gatgtaggtg ttccacaggg tagccagcag catcctgcga tgcagatccg 3360
gaacataatg gtgcagggcg ctgacttccg cgtttccaga ctttacgaaa cacggaaacc 3420
gaagaccatt catgttgttg ctcaggtcgc agacgttttg cagcagcagt cgcttcacgt 3480
tcgctcgcgt atcggtgatt cattctgcta accagtaagg caaccccgcc agcctagccg 3540
ggtcctcaac gacaggagca cgatcatgcg cacccgtggg gccgccatgc cggcgataat 3600
ggcctgcttc tcgccgaaac gtttggtggc gggaccagtg acgaaggctt gagcgagggc 3660
gtgcaagatt ccgaataccg caagcgacag gccgatcatc gtcgcgctcc agcgaaagcg 3720
gtcctcgccg aaaatgaccc agagcgctgc cggcacctgt cctacgagtt gcatgataaa 3780
gaagacagtc ataagtgcgg cgacgatagt catgccccgc gcccaccgga aggagctgac 3840
tgggttgaag gctctcaagg gcatcggtcg agatcccggt gcctaatgag tgagctaact 3900
tacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct 3960
gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc gccagggtgg 4020
tttttctttt caccagtgag acgggcaaca gctgattgcc cttcaccgcc tggccctgag 4080
agagttgcag caagcggtcc acgctggttt gccccagcag gcgaaaatcc tgtttgatgg 4140
tggttaacgg cgggatataa catgagctgt cttcggtatc gtcgtatccc actaccgaga 4200
tatccgcacc aacgcgcagc ccggactcgg taatggcgcg cattgcgccc agcgccatct 4260
gatcgttggc aaccagcatc gcagtgggaa cgatgccctc attcagcatt tgcatggttt 4320
gttgaaaacc ggacatggca ctccagtcgc cttcccgttc cgctatcggc tgaatttgat 4380
tgcgagtgag atatttatgc cagccagcca gacgcagacg cgccgagaca gaacttaatg 4440
ggcccgctaa cagcgcgatt tgctggtgac ccaatgcgac cagatgctcc acgcccagtc 4500
gcgtaccgtc ttcatgggag aaaataatac tgttgatggg tgtctggtca gagacatcaa 4560
gaaataacgc cggaacatta gtgcaggcag cttccacagc aatggcatcc tggtcatcca 4620
gcggatagtt aatgatcagc ccactgacgc gttgcgcgag aagattgtgc accgccgctt 4680
tacaggcttc gacgccgctt cgttctacca tcgacaccac cacgctggca cccagttgat 4740
cggcgcgaga tttaatcgcc gcgacaattt gcgacggcgc gtgcagggcc agactggagg 4800
tggcaacgcc aatcagcaac gactgtttgc ccgccagttg ttgtgccacg cggttgggaa 4860
tgtaattcag ctccgccatc gccgcttcca ctttttcccg cgttttcgca gaaacgtggc 4920
tggcctggtt caccacgcgg gaaacggtct gataagagac accggcatac tctgcgacat 4980
cgtataacgt tactggtttc acattcacca ccctgaattg actctcttcc gggcgctatc 5040
atgccatacc gcgaaaggtt ttgcgccatt cgatggtgtc cgggatctcg acgctctccc 5100
ttatgcgact cctgcattag gaagcagccc agtagtaggt tgaggccgtt gagcaccgcc 5160
gccgcaagga atggtgcatg caaggagatg gcgcccaaca gtcccccggc cacggggcct 5220
gccaccatac ccacgccgaa acaagcgctc atgagcccga agtggcgagc ccgatcttcc 5280
ccatcggtga tgtcggcgat ataggcgcca gcaaccgcac ctgtggcgcc ggtgatgccg 5340
gccacgatgc gtccggcgta gaggatcga                                   5369



<210> 534
<211> 1353
<212> DNA
<213> Artificial Sequence

<220> 
<223> hMMP-1

<220> 
<221> CDS            
<222> (1)...(1353)
<223> Pro MMP-1

<220> 
<221> CDS            
<222> (241)...(726)
<223> Catalytic Domain

<220> 
<221> CDS            
<222> (727)...(774)
<223> Linker Region

<400> 534
ttc cca gcg act cta gaa aca caa gag caa gat gtg gac tta gtc cag   48
Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp Leu Val Gln
 1               5                   10                  15
 
aaa tac ctg gaa aaa tac tac aac ctg aag aat gat ggg agg caa gtt   96
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Arg Gln Val
             20                  25                  30
 
gaa aag cgg aga aat agt ggc cca gtg gtt gaa aaa ttg aag caa atg   144
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
         35                  40                  45
 
cag gaa ttc ttt ggg ctg aaa gtg act ggg aaa cca gat gct gaa acc   192
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
     50                  55                  60
 
ctg aag gtg atg aag cag ccc aga tgt gga gtg cct gat gtg gct cag   240
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
 65                  70                  75                  80
 
ttt gtc ctc act gag ggg aac cct cgc tgg gag caa aca cat ctg acc   288
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Thr
                 85                  90                  95
 
tac agg att gaa aat tac acg cca gat ttg cca aga gca gat gtg gac   336
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110
 
cat gcc att gag aaa gcc ttc caa ctc tgg agt aat gtc aca cct ctg   384
His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125
 
aca ttc acc aag gtc tct gag ggt caa gca gac atc atg ata tct ttt   432
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140
 
gtc agg gga gat cat cgg gac aac tct cct ttt gat gga cct gga gga   480
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160
 
aat ctt gct cat gct ttt caa cca ggc cca ggt att gga ggg gat gct   528
Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly Gly Asp Ala
                165                 170                 175
 
cat ttt gat gaa gat gaa agg tgg acc aac aat ttc aga gag tac aac   576
His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg Glu Tyr Asn
            180                 185                 190
 
tta cat cgt gtt gcg gct cat gaa ctc ggc cat tct ctt gga ctc tcc   624
Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205
 
cat tct act gat atc ggg gct ttg atg tac cct agc tac acc ttc agt   672
His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220
 
ggt gat gtt cag cta gct cag gat gac att gat ggc atc caa gcc ata   720
Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240
 
tat gga cgt tcc caa aat cct gtc cag ccc atc ggc cca caa acc cca   768
Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Gln Thr Pro
                245                 250                 255
 
aaa gcg tgt gac agt aag cta acc ttt gat gct ata act acg att cgg   816
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270
 
gga gaa gtg atg ttc ttt aaa gac aga ttc tac atg cgc aca aat ccc   864
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Thr Asn Pro
        275                 280                 285
 
ttc tac ccg gaa gtt gag ctc aat ttc att tct gtt ttc tgg cca caa   912
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300
 
ctg cca aat ggg ctt gaa gct gct tac gaa ttt gcc gac aga gat gaa   960
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp Arg Asp Glu
305                 310                 315                 320
 
gtc cgg ttt ttc aaa ggg aat aag tac tgg gct gtt cag gga cag aat   1008
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335
 
gtg cta cac gga tac ccc aag gac atc tac agc tcc ttt ggc ttc cct   1056
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350
 
aga act gtg aag cat atc gat gct gct ctt tct gag gaa aac act gga   1104
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365
 
aaa acc tac ttc ttt gtt gct aac aaa tac tgg agg tat gat gaa tat   1152
Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380
 
aaa cga tct atg gat cca ggt tat ccc aaa atg ata gca cat gac ttt   1200
Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400
 
cct gga att ggc cac aaa gtt gat gca gtt ttc atg aaa gat gga ttt   1248
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415
 
ttc tat ttc ttt cat gga aca aga caa tac aaa ttt gat cct aaa acg   1296
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Thr
            420                 425                 430
 
aag aga att ttg act ctc cag aaa gct aat agc tgg ttc aac tgc agg   1344
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445
 
aaa aat tga                                                       1353
Lys Asn  
    450


<210> 535
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> fluorescence substrate

<220> 
<221> MOD_RES        
<222> 1
<223> 7-Methoxycoumarin-4-yl)acetyl

<220> 
<221> MOD_RES        
<222> 7
<223> 2,4,-Dinitrophenyl)-L-2,3-diaminopropionyll

<400> 535
Xaa Lys Pro Leu Gly Leu Xaa Ala Arg
 1               5                  


<210> 536
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> fluorescence substrate

<220> 
<221> MOD_RES        
<222> 1
<223> Xaa at position 1 is N-carbobenzyloxy

<220> 
<221> MOD_RES        
<222> 6
<223> Xaa at position 6 is 7-Amino-4-Methyl Coumarin

<400> 536
Xaa His Arg Tyr Arg Xaa
 1               5                  


<210> 537
<211> 450
<212> PRT
<213> Homo sapiens

<220> 
<223> allelic variants of MMP-1

<220> 
<221> VARIANT        
<222> 4, 10, 254
<223> Xaa = Pro

<220> 
<221> VARIANT        
<222> 30
<223> Xaa = Met or Ser

<220> 
<221> VARIANT        
<222> 96
<223> Xaa = Arg

<220> 
<221> VARIANT        
<222> 114, 172
<223> Xaa = Val


<220> 
<221> VARIANT        
<222> 166
<223> Xaa = Cys


<220> 
<221> VARIANT        
<222> 181, 
<223> Xaa = His


<220> 
<221> VARIANT        
<222> 189, 298, 387
<223> Xaa = Thr


<220> 
<221> VARIANT        
<222> 200, 286, 432
<223> Xaa = Ala


<220> 
<221> VARIANT        
<222> 214
<223> Xaa = Glu


<220> 
<221> VARIANT        
<222> 232
<223> Xaa = Asn


<220> 
<221> VARIANT        
<222> 233, 314
<223> Xaa = Gly


<220> 
<221> VARIANT        
<222> 315, 391
<223> Xaa = Ser


<220> 
<221> VARIANT        
<222> 374
<223> Xaa = Met


<220> 
<221> VARIANT        
<222> 386
<223> Xaa = Gln

<400> 537
Phe Pro Ala Xaa Leu Glu Thr Gln Glu Xaa Asp Val Asp Leu Val Gln
 1               5                  10                  15      
Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly Xaa Gln Val
            20                  25                  30          
Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu Lys Gln Met
        35                  40                  45              
Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp Ala Glu Thr
    50                  55                  60                  
Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp Val Ala Gln
65                  70                  75                  80  
Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr His Leu Xaa
                85                  90                  95      
Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala Asp Val Asp
            100                 105                 110         
His Xaa Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val Thr Pro Leu
        115                 120                 125             
Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met Ile Ser Phe
    130                 135                 140                 
Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly Pro Gly Gly
145                 150                 155                 160 
Asn Leu Ala His Ala Xaa Gln Pro Gly Pro Gly Xaa Gly Gly Asp Ala
                165                 170                 175     
His Phe Asp Glu Xaa Glu Arg Trp Thr Asn Asn Phe Xaa Glu Tyr Asn
            180                 185                 190         
Leu His Arg Val Ala Ala His Xaa Leu Gly His Ser Leu Gly Leu Ser
        195                 200                 205             
His Ser Thr Asp Ile Xaa Ala Leu Met Tyr Pro Ser Tyr Thr Phe Ser
    210                 215                 220                 
Gly Asp Val Gln Leu Ala Xaa Xaa Asp Ile Asp Gly Ile Gln Ala Ile
225                 230                 235                 240 
Tyr Gly Xaa Ser Gln Asn Pro Val Gln Pro Ile Gly Pro Xaa Thr Pro
                245                 250                 255     
Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr Thr Ile Arg
            260                 265                 270         
Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg Xaa Asn Pro
        275                 280                 285             
Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe Trp Pro Gln
    290                 295                 300                 
Leu Pro Asn Gly Leu Glu Ala Ala Tyr Xaa Xaa Ala Asp Arg Asp Glu
305                 310                 315                 320 
Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln Gly Gln Asn
                325                 330                 335     
Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe Gly Phe Pro
            340                 345                 350         
Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu Asn Thr Gly
        355                 360                 365             
Lys Thr Tyr Phe Phe Xaa Ala Asn Lys Tyr Trp Arg Tyr Asp Glu Tyr
    370                 375                 380                 
Lys Xaa Xaa Met Asp Pro Xaa Tyr Pro Lys Met Ile Ala His Asp Phe
385                 390                 395                 400 
Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys Asp Gly Phe
                405                 410                 415     
Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp Pro Lys Xaa
            420                 425                 430         
Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe Asn Cys Arg
        435                 440                 445             
Lys Asn
    450 



