                         SEQUENCE LISTING

<110>  3M Innovative Properties Company
       Rajagopal, Raj
       Wei, Ai-Ping
 
<120>  ANTIBODIES TO CLOSTRIDIUM DIFFICILE SPORES AND USES THEREOF

<130>  63842WO003

<150>  US 61/032270
<151>  2008-02-28

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  635
<212>  PRT
<213>  Clostridium difficile

<400>  1

Met Lys Asp Lys Lys Phe Thr Leu Leu Ile Ser Ile Met Ile Val Phe 
1               5                   10                  15      


Leu Cys Ala Val Val Gly Val Tyr Ser Thr Ser Ser Asn Lys Ser Val 
            20                  25                  30          


Asp Leu Tyr Ser Asp Val Tyr Ile Glu Lys Tyr Phe Asn Arg Asp Lys 
        35                  40                  45              


Val Met Glu Val Asn Ile Glu Ile Asp Glu Ser Asp Leu Lys Asp Met 
    50                  55                  60                  


Asn Glu Asn Ala Ile Lys Glu Glu Phe Lys Val Ala Lys Val Thr Val 
65                  70                  75                  80  


Asp Gly Asp Thr Tyr Gly Asn Val Gly Ile Arg Thr Lys Gly Asn Ser 
                85                  90                  95      


Ser Leu Ile Ser Val Ala Asn Ser Asp Ser Asp Arg Tyr Ser Tyr Lys 
            100                 105                 110         


Ile Asn Phe Asp Lys Tyr Asn Thr Ser Gln Ser Met Glu Gly Leu Thr 
        115                 120                 125             


Gln Leu Asn Leu Asn Asn Cys Tyr Ser Asp Pro Ser Tyr Met Arg Glu 
    130                 135                 140                 


Phe Leu Thr Tyr Ser Ile Cys Glu Glu Met Gly Leu Ala Thr Pro Glu 
145                 150                 155                 160 


Phe Ala Tyr Ala Lys Val Ser Ile Asn Gly Glu Tyr His Gly Leu Tyr 
                165                 170                 175     


Leu Ala Val Glu Gly Leu Lys Glu Ser Tyr Leu Glu Asn Asn Phe Gly 
            180                 185                 190         


Asn Val Thr Gly Asp Leu Tyr Lys Ser Asp Glu Gly Ser Ser Leu Gln 
        195                 200                 205             


Tyr Lys Gly Asp Asp Pro Glu Ser Tyr Ser Asn Leu Ile Val Glu Ser 
    210                 215                 220                 


Asp Lys Lys Thr Ala Asp Trp Ser Lys Ile Thr Lys Leu Leu Lys Ser 
225                 230                 235                 240 


Leu Asp Thr Gly Glu Asp Ile Glu Lys Tyr Leu Asp Val Asp Ser Val 
                245                 250                 255     


Leu Lys Asn Ile Ala Ile Asn Thr Ala Leu Leu Asn Leu Asp Ser Tyr 
            260                 265                 270         


Gln Gly Ser Phe Ala His Asn Tyr Tyr Leu Tyr Glu Gln Asp Gly Val 
        275                 280                 285             


Phe Ser Met Leu Pro Trp Asp Phe Asn Met Ser Phe Gly Gly Phe Ser 
    290                 295                 300                 


Gly Phe Gly Gly Gly Ser Gln Ser Ile Ala Ile Asp Glu Pro Thr Thr 
305                 310                 315                 320 


Gly Asn Leu Glu Asp Arg Pro Leu Ile Ser Ser Leu Leu Lys Asn Glu 
                325                 330                 335     


Thr Tyr Lys Thr Lys Tyr His Lys Tyr Leu Glu Glu Ile Val Thr Lys 
            340                 345                 350         


Tyr Leu Asp Ser Asp Tyr Leu Glu Asn Met Thr Thr Lys Leu His Asp 
        355                 360                 365             


Met Ile Ala Ser Tyr Val Lys Glu Asp Pro Thr Ala Phe Tyr Thr Tyr 
    370                 375                 380                 


Glu Glu Phe Glu Lys Asn Ile Thr Ser Ser Ile Glu Asp Ser Ser Asp 
385                 390                 395                 400 


Asn Lys Gly Phe Gly Asn Lys Gly Phe Asp Asn Asn Asn Ser Asn Asn 
                405                 410                 415     


Ser Asp Ser Asn Asn Asn Ser Asn Ser Glu Asn Lys Arg Ser Gly Asn 
            420                 425                 430         


Gln Ser Asp Glu Lys Glu Val Asn Ala Glu Leu Thr Ser Ser Val Val 
        435                 440                 445             


Lys Ala Asn Thr Asp Asn Glu Thr Lys Asn Lys Thr Thr Asn Asp Ser 
    450                 455                 460                 


Glu Ser Lys Asn Asn Thr Asp Lys Asp Lys Ser Gly Asn Asp Asn Asn 
465                 470                 475                 480 


Gln Lys Leu Glu Gly Pro Met Gly Lys Gly Gly Lys Ser Ile Pro Gly 
                485                 490                 495     


Val Leu Glu Val Ala Glu Asp Met Ser Lys Thr Ile Lys Ser Gln Leu 
            500                 505                 510         


Ser Gly Glu Thr Ser Ser Thr Lys Gln Asn Ser Gly Asp Glu Ser Ser 
        515                 520                 525             


Ser Gly Ile Lys Gly Ser Glu Lys Phe Asp Glu Asp Met Ser Gly Met 
    530                 535                 540                 


Pro Glu Pro Pro Glu Gly Met Asp Gly Lys Met Pro Pro Gly Met Gly 
545                 550                 555                 560 


Asn Met Asp Lys Gly Asp Met Asn Gly Lys Asn Gly Asn Met Asn Met 
                565                 570                 575     


Asp Arg Asn Gln Asp Asn Pro Arg Glu Ala Gly Gly Phe Gly Asn Arg 
            580                 585                 590         


Gly Gly Gly Ser Val Ser Lys Thr Thr Thr Tyr Phe Lys Leu Ile Leu 
        595                 600                 605             


Gly Gly Ala Ser Met Ile Ile Met Ser Ile Met Leu Val Gly Val Ser 
    610                 615                 620                 


Arg Val Lys Arg Arg Arg Phe Ile Lys Ser Lys 
625                 630                 635 


<210>  2
<211>  100
<212>  PRT
<213>  Clostridium difficile

<400>  2

Ser Lys Thr Ile Lys Ser Gln Leu Ser Gly Glu Thr Ser Ser Thr Lys 
1               5                   10                  15      


Gln Asn Ser Gly Asp Glu Ser Ser Ser Gly Ile Lys Gly Ser Glu Lys 
            20                  25                  30          


Phe Asp Glu Asp Met Ser Gly Met Pro Glu Pro Pro Glu Gly Met Asp 
        35                  40                  45              


Gly Lys Met Pro Pro Gly Met Gly Asn Met Asp Lys Gly Asp Met Asn 
    50                  55                  60                  


Gly Lys Asn Gly Asn Met Asn Met Asp Arg Asn Gln Asp Asn Pro Arg 
65                  70                  75                  80  


Glu Ala Gly Gly Phe Gly Asn Arg Gly Gly Gly Ser Val Ser Lys Thr 
                85                  90                  95      


Thr Thr Tyr Phe 
            100 


<210>  3
<211>  15
<212>  PRT
<213>  Clostridium difficile

<400>  3

Glu Gly Ser Ser Leu Gln Tyr Lys Gly Asp Asp Pro Glu Ser Tyr 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  Clostridium difficile

<400>  4

Leu Lys Asn Glu Thr Tyr Lys Thr Lys Tyr His Lys Tyr Leu Glu 
1               5                   10                  15  


<210>  5
<211>  677
<212>  PRT
<213>  Clostridium difficile

<400>  5

Met Leu Ser Lys Glu Ile Asn Met Arg Arg Asn Thr Lys Leu Leu Thr 
1               5                   10                  15      


Thr Gly Ile Leu Ser Met Ala Ile Val Ala Pro Thr Met Ala Phe Ala 
            20                  25                  30          


Thr Glu Ser Asn Ala Met Glu Asn Asn Ala Asp Leu Asn Ile Asn Leu 
        35                  40                  45              


Glu Lys Lys Ser Ile Val Leu Gly Ser Lys Ser Lys Val Ser Val Lys 
    50                  55                  60                  


Phe Lys Glu Lys Pro Asp Ala Asp Ser Ile Lys Leu Lys Tyr Lys Cys 
65                  70                  75                  80  


Tyr Asp Met Pro Leu Asn Thr Thr Leu Asn Tyr Asn Gln Ser Thr Gly 
                85                  90                  95      


Ala Tyr Glu Gly Ile Ile Asn Tyr Asn Lys Asp Pro Glu Tyr Leu Asn 
            100                 105                 110         


Val Trp Glu Leu Gln Gly Ile Thr Ile Asn Ser Lys Thr Asn Pro Lys 
        115                 120                 125             


Thr Leu Asn Arg Gln Asp Leu Glu Lys Met Gly Leu Asn Leu Lys Asp 
    130                 135                 140                 


Tyr Asn Val Thr Gln Glu Cys Ile Ile Glu Asp Ile Thr Ser Arg Lys 
145                 150                 155                 160 


Asp Val Asn Lys Tyr Leu Arg Lys Thr Ser Ser Pro Ile Thr Glu Leu 
                165                 170                 175     


Thr Gly Ser Asp Arg Tyr Glu Thr Ala Val Lys Ile Ser Lys Glu Gly 
            180                 185                 190         


Trp Lys Asn Gly Ser Asp Lys Val Val Ile Ile Asn Gly Asp Val Ser 
        195                 200                 205             


Ile Asp Gly Ile Ile Ser Thr Pro Leu Ala Thr Thr Tyr Asn Ala Pro 
    210                 215                 220                 


Ile Leu Leu Val Glu Lys Asn Asn Val Pro Asn Ser Val Lys Ser Glu 
225                 230                 235                 240 


Leu Lys Arg Leu Asn Pro Lys Asp Ile Ile Ile Ile Gly Asp Glu Asn 
                245                 250                 255     


Ala Ile Ser Lys Thr Thr Ala Asn Gln Ile Lys Ser Thr Val Asn Ala 
            260                 265                 270         


Ser Gln Thr Arg Leu Asn Gly Ser Asn Arg Tyr Glu Thr Ser Leu Leu 
        275                 280                 285             


Ile Ala Lys Glu Ile Asp Lys Asn His Asp Val Glu Lys Val Tyr Ile 
    290                 295                 300                 


Thr Asn Ala Asn Gly Gly Glu Val Asp Ala Leu Thr Ile Ala Ala Lys 
305                 310                 315                 320 


Ala Gly Gln Asp Lys Gln Pro Ile Ile Leu Thr Asp Lys Asp Ser Ile 
                325                 330                 335     


Thr Asp Asn Thr Tyr Lys Trp Leu Lys Ser Glu Asp Leu Gln Asn Ala 
            340                 345                 350         


Tyr Phe Ile Gly Gly Pro Gln Met Ile Ser Thr Asn Val Ile Asn Lys 
        355                 360                 365             


Val Asn Gly Ile Thr Lys Asp Ser Val Thr Asn Asn Arg Val Tyr Gly 
    370                 375                 380                 


Ala Asp Arg His Glu Thr Asn Ala Asn Val Ile Lys Lys Phe Tyr Thr 
385                 390                 395                 400 


Asp Asp Glu Leu Glu Ala Val Leu Val Ala Lys Ser Asp Val Leu Val 
                405                 410                 415     


Asp Ala Leu Ala Ala Gly Pro Leu Ala Ala Asn Leu Lys Ser Pro Ile 
            420                 425                 430         


Leu Ile Thr Pro Lys Thr Tyr Val Ser Ala Tyr His Lys Asp Asn Leu 
        435                 440                 445             


Glu Ala Lys Ser Ala Asn Lys Val Tyr Lys Ile Gly Gly Gly Leu Thr 
    450                 455                 460                 


Ser Lys Val Met Ser Ser Ile Ala Ser Ser Leu Ser Lys His Asn Thr 
465                 470                 475                 480 


Thr Pro Thr Glu Pro Gly Asn Ser Gly Gly Lys Thr Val Met Ile Asp 
                485                 490                 495     


Pro Gly His Gly Gly Ser Ala Pro Gly Asn Ser Ser Gly Gly Met Ile 
            500                 505                 510         


Glu Lys Asp Tyr Asn Leu Asn Thr Ser Leu Ala Thr Thr Glu Tyr Leu 
        515                 520                 525             


Arg Ser Lys Gly Phe Asn Val Ile Met Thr Arg Asp Thr Asp Lys Thr 
    530                 535                 540                 


Leu Ser Leu Gly Asn Arg Thr Ala Leu Ser Asn Ser Leu Lys Pro Asp 
545                 550                 555                 560 


Leu Phe Thr Ser Ile His Tyr Asn Gly Ser Thr Asn Lys Gln Gly His 
                565                 570                 575     


Gly Val Glu Val Phe Tyr Lys Leu Lys Asp Lys Asn Gly Gly Thr Thr 
            580                 585                 590         


Lys Thr Val Ala Thr Asn Ile Leu Asn Arg Ile Leu Glu Lys Phe Lys 
        595                 600                 605             


Leu Thr Asn Arg Gly Ile Lys Thr Arg Val Leu Pro Ser Asp Ser Thr 
    610                 615                 620                 


Lys Asp Tyr Leu Tyr Val Leu Arg Ser Asn Asp Met Pro Ala Val Leu 
625                 630                 635                 640 


Val Glu Cys Ala Phe Leu Asp Asn Glu Asn Asp Met Ser Leu Ile Asn 
                645                 650                 655     


Ser Ser Ala Lys Val Lys Glu Met Gly Thr Gln Ile Gly Lys Gly Ile 
            660                 665                 670         


Glu Asp Ser Leu Lys 
        675         


<210>  6
<211>  99
<212>  PRT
<213>  Clostridium difficile

<400>  6

Asp Lys Asn His Asp Val Glu Lys Val Tyr Ile Thr Asn Ala Asn Gly 
1               5                   10                  15      


Gly Glu Val Asp Ala Leu Thr Ile Ala Ala Lys Ala Gly Gln Asp Lys 
            20                  25                  30          


Gln Pro Ile Ile Leu Thr Asp Lys Asp Ser Ile Thr Asp Asn Tyr Lys 
        35                  40                  45              


Trp Leu Lys Ser Glu Asp Leu Gln Asn Ala Tyr Phe Ile Gly Gly Pro 
    50                  55                  60                  


Gln Met Ile Ser Thr Asn Val Ile Asn Lys Val Asn Gly Ile Thr Lys 
65                  70                  75                  80  


Asp Ser Val Thr Asn Asn Arg Val Tyr Gly Ala Asp Arg His Glu Thr 
                85                  90                  95      


Asn Ala Asn 
            


<210>  7
<211>  15
<212>  PRT
<213>  Clostridium difficile

<400>  7

Tyr Lys Leu Lys Asp Lys Asn Gly Gly Thr Thr Lys Thr Val Ala 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Clostridium difficile

<400>  8

Lys Phe Lys Glu Lys Pro Asp Ala Asp Ser Ile Lys Leu Lys Tyr 
1               5                   10                  15  


<210>  9
<211>  91
<212>  PRT
<213>  Clostridium difficile

<400>  9

Lys Ser Val Asp Leu Tyr Ser Asp Val Tyr Ile Glu Lys Tyr Phe Asn 
1               5                   10                  15      


Arg Asp Lys Val Met Glu Val Asn Ile Glu Ile Asp Glu Ser Asp Leu 
            20                  25                  30          


Lys Asp Met Asn Glu Asn Ala Ile Lys Glu Glu Phe Lys Val Ala Lys 
        35                  40                  45              


Val Thr Val Asp Gly Asp Thr Tyr Gly Asn Val Gly Ile Arg Thr Lys 
    50                  55                  60                  


Gly Asn Ser Ser Leu Ile Ser Val Ala Asn Ser Asp Ser Asp Arg Tyr 
65                  70                  75                  80  


Ser Tyr Lys Ile Asn Phe Asp Lys Tyr Asn Thr 
                85                  90      


<210>  10
<211>  100
<212>  PRT
<213>  Clostridium difficile

<400>  10

Val Thr Gly Asp Leu Tyr Lys Ser Asp Glu Gly Ser Ser Leu Gln Tyr 
1               5                   10                  15      


Lys Gly Asp Asp Pro Glu Ser Tyr Ser Asn Leu Ile Val Glu Ser Asp 
            20                  25                  30          


Lys Lys Thr Ala Asp Trp Ser Lys Ile Thr Lys Leu Leu Lys Ser Leu 
        35                  40                  45              


Asp Thr Gly Glu Asp Ile Glu Lys Tyr Leu Asp Val Asp Ser Val Leu 
    50                  55                  60                  


Lys Asn Ile Ala Ile Asn Thr Ala Leu Leu Asn Leu Asp Ser Tyr Gln 
65                  70                  75                  80  


Gly Ser Phe Ala His Asn Tyr Tyr Leu Tyr Glu Gln Asp Gly Val Phe 
                85                  90                  95      


Ser Met Leu Pro 
            100 


<210>  11
<211>  323
<212>  PRT
<213>  Clostridium difficile

<400>  11

Met Ile Ile Phe Leu Cys Ala Val Val Gly Val Tyr Ser Thr Ser Ser 
1               5                   10                  15      


Asn Lys Ser Val Asp Leu Tyr Ser Asp Val Tyr Ile Glu Lys Tyr Phe 
            20                  25                  30          


Asn Arg Asp Lys Val Met Glu Val Asn Ile Glu Ile Asp Glu Ser Asp 
        35                  40                  45              


Leu Lys Asp Met Asn Glu Asn Ala Ile Lys Glu Glu Phe Lys Val Ala 
    50                  55                  60                  


Lys Val Thr Val Asp Gly Asp Thr Tyr Gly Asn Val Gly Ile Arg Thr 
65                  70                  75                  80  


Lys Gly Asn Ser Ser Leu Thr Ser Val Ala Asn Ser Asp Ser Asp Arg 
                85                  90                  95      


Tyr Ser Tyr Lys Ile Asn Phe Asp Lys Tyr Asn Thr Ser Gln Ser Met 
            100                 105                 110         


Glu Gly Leu Thr Gln Leu Asn Leu Asn Asn Cys Tyr Ser Asp Pro Ser 
        115                 120                 125             


Tyr Met Arg Glu Phe Leu Thr Tyr Ser Ile Cys Glu Glu Met Gly Leu 
    130                 135                 140                 


Ala Thr Pro Glu Phe Ala Tyr Ala Lys Val Ser Ile Asn Gly Glu Tyr 
145                 150                 155                 160 


His Gly Leu Tyr Leu Ala Val Glu Gly Leu Lys Glu Ser Tyr Leu Glu 
                165                 170                 175     


Asn Asn Phe Gly Asn Val Thr Gly Asp Leu Tyr Lys Ser Asp Glu Gly 
            180                 185                 190         


Ser Ser Leu Gln Tyr Lys Gly Asp Asp Pro Glu Ser Tyr Ser Asn Leu 
        195                 200                 205             


Ile Val Glu Ser Asp Lys Lys Thr Ala Asp Trp Ser Lys Ile Thr Lys 
    210                 215                 220                 


Leu Leu Lys Ser Leu Asp Thr Gly Glu Asp Ile Glu Lys Tyr Leu Asp 
225                 230                 235                 240 


Val Asp Ser Val Leu Lys Asn Ile Ala Ile Asn Thr Ala Leu Leu Asn 
                245                 250                 255     


Leu Asp Ser Tyr Gln Gly Ser Phe Ala His Asn Tyr Tyr Leu Tyr Glu 
            260                 265                 270         


Gln Asp Gly Val Phe Ser Met Leu Pro Trp Asp Phe Asn Met Ser Phe 
        275                 280                 285             


Gly Gly Phe Ser Gly Phe Gly Gly Gly Ser Gln Ser Ile Ala Ile Asp 
    290                 295                 300                 


Glu Pro Thr Thr Gly Asn Leu Glu Asp Arg Pro Leu Ile Ser Ser Leu 
305                 310                 315                 320 


Leu Lys Lys 
            


<210>  12
<211>  274
<212>  PRT
<213>  Clostridium difficile

<400>  12

Met Thr Thr Lys Leu His Asp Met Ile Ala Ser Tyr Val Lys Glu Asp 
1               5                   10                  15      


Pro Thr Ala Phe Tyr Thr Tyr Glu Glu Phe Glu Lys Asn Ile Thr Ser 
            20                  25                  30          


Ser Ile Glu Asp Ser Ser Asp Asn Lys Gly Phe Gly Asn Lys Gly Phe 
        35                  40                  45              


Asp Asn Asn Asn Ser Asn Asn Ser Asp Ser Asn Asn Asn Ser Asn Ser 
    50                  55                  60                  


Glu Asn Lys Arg Ser Gly Asn Gln Ser Asp Lys Lys Glu Val Asn Ala 
65                  70                  75                  80  


Glu Leu Thr Ser Ser Val Val Lys Thr Asn Thr Asp Asn Glu Thr Glu 
                85                  90                  95      


Asn Lys Thr Thr Asn Asp Ser Glu Ser Lys Asn Asn Thr Asp Lys Asp 
            100                 105                 110         


Lys Ser Gly Asn Asp Asn Asn Gln Lys Leu Glu Gly Pro Arg Gly Lys 
        115                 120                 125             


Gly Gly Lys Ser Ile Pro Gly Val Leu Glu Val Ala Glu Asp Met Ser 
    130                 135                 140                 


Lys Thr Ile Lys Ser Gln Leu Ser Gly Glu Thr Ser Ser Thr Lys Gln 
145                 150                 155                 160 


Asn Ser Gly Asp Glu Ser Ser Ser Gly Ile Lys Gly Ser Glu Lys Phe 
                165                 170                 175     


Asp Glu Asp Met Ser Gly Met Pro Glu Pro Pro Glu Gly Met Asp Gly 
            180                 185                 190         


Lys Met Pro Pro Gly Met Gly Asn Met Asp Lys Gly Asp Met Asn Gly 
        195                 200                 205             


Lys Asn Gly Asn Met Asn Met Asp Arg Asn Gln Asp Asn Pro Arg Glu 
    210                 215                 220                 


Ala Gly Gly Phe Gly Asn Arg Gly Gly Gly Ser Val Ser Lys Thr Thr 
225                 230                 235                 240 


Thr Tyr Phe Lys Leu Ile Leu Gly Gly Ala Ser Met Ile Ile Met Ser 
                245                 250                 255     


Ile Met Leu Val Gly Val Ser Arg Val Lys Arg Arg Arg Phe Ile Lys 
            260                 265                 270         


Ser Lys 
        


<210>  13
<211>  999
<212>  DNA
<213>  Clostridium difficile

<400>  13
aagataaaaa aatttaccct tcttatctct attatgatta tatttttatg tgctgtagtt       60

ggagtttata gtacatctag caacaaaagt gttgatttat atagtgatgt atatattgaa      120

aaatatttta acagagacaa ggttatggaa gttaatatag agatagatga aagtgacttg      180

aaggatatga atgaaaatgc tataaaagaa gaatttaagg ttgcaaaagt aactgtagat      240

ggagatacat atggaaacgt aggtataaga actaaaggaa attcaagtct tacatctgta      300

gcaaatagtg atagtgatag atacagctat aagattaatt ttgataagta taatactagt      360

caaagtatgg aagggcttac tcaattaaat cttaataact gttactctga cccatcttat      420

atgagagagt ttttaacata tagtatttgc gaggaaatgg gattagcgac tccagaattt      480

gcatatgcta aagtctctat aaatggcgaa tatcatggtt tgtatttggc agtagaagga      540

ttaaaagagt cttatcttga aaataatttt ggtaatgtaa ctggagactt atataagtca      600

gatgaaggaa gctcgttgca atataaagga gatgacccag aaagttactc aaacttaatc      660

gttgaaagtg ataaaaagac agctgattgg tctaaaatta caaaactatt aaaatctttg      720

gatacaggtg aagatattga aaaatatctt gatgtagatt ctgtccttaa aaatatagca      780

ataaatacag ctttattaaa ccttgatagc tatcaaggca gttttgccca taactattat      840

ttatatgagc aagatggagt attttctatg ttaccatggg attttaatat gtcatttggt      900

ggatttagtg gttttggtgg aggtagtcaa tctatagcaa ttgatgaacc tacgacaggt      960

aatttagaag acagacctct catatcctcg ttattaaaa                             999


<210>  14
<211>  909
<212>  DNA
<213>  Clostridium difficile

<400>  14
aaaaatgaga cacacaaaac aaaataccat aaatatctgg aagagatagt aacaaaatac       60

ctagattcag actatttaga gaatatgaca acaaaattgc atgacatgat agcatcatat      120

gtaaaagaag acccaacagc attttatact tatgaagaat ttgaaaaaaa tataacatct      180

tcaattgaag attctagtga taataaggga tttggtaata aagggtttga caacaataac      240

tctaataaca gtgattctaa taataattct aatagtgaaa ataagcgctc tggaaatcaa      300

agtgataaaa aagaagttaa tgctgaatta acatcaagcg tagtcaaaac taatacagat      360

aatgaaactg aaaataaaac tacaaatgat agcgaaagta agaataatac agataaagat      420

aaaagtggaa atgataataa tcaaaagcta gaaggtccta ggggtaaagg aggtaagtca      480

ataccagggg ttttggaagt tgcagaagat atgagtaaaa ctataaaatc tcaattaagt      540

ggagaaactt cttcgacaaa gcaaaactct ggtgatgaaa gttcaagtgg aattaaaggt      600

agtgaaaagt ttgatgagga tatgagtggt atgccagaac cacctgaggg aatggatggt      660

aaaatgccac caggaatggg taatatggat aagggagata tgaatggtaa aaatggcaat      720

atgaatatgg atagaaatca agataatcca agagaagctg gaggttttgg caatagagga      780

ggaggctctg tgagtaaaac aacaacatac ttcaaattaa ttttaggtgg agcttcaatg      840

ataataatgt cgattatgtt agtaggtgta tcaagggtaa agagaagaag atttataaag      900

tcaaaataa                                                              909


<210>  15
<211>  1907
<212>  DNA
<213>  Clostridium difficile

<400>  15
atgaaagata aaaaatttac ccttcttatc tctattatga ttatattttt atgtgctgta       60

ttggagttta tagtacatct agcaacaaaa gtgttgattt atatagtgat gtatatattg      120

aaaaatattt taacagagac aaggttatgg aagttaatat agagatagat gaaagtgact      180

tgaaggatat gaatgaaaat gctataaaag aagaatttaa ggttgcaaaa gtaactgtag      240

atggagatac atatggaaac gtaggtataa gaactaaagg aaattcaagt cttacatctg      300

tagcaaatag tgatagtgat agatacagct ataagattaa ttttgataag tataatacta      360

gtcaaagtat ggaagggctt actcaattaa atcttaataa ctgttactct gacccatctt      420

atatgagaga gtttttaaca tatagtattt gcgaggaaat gggattagcg actccagaat      480

ttgcatatgc taaagtctct ataaatggcg aatatcatgg tttgtatttg gcagtagaag      540

gattaaaaga gtcttatctt gaaaataatt ttggtaatgt aactggagac ttatataagt      600

cagatgaagg aagctcgttg caatataaag gagatgaccc agaaagttac tcaaacttaa      660

tcgttgaaag tgataaaaag acagctgatt ggtctaaaat tacaaaacta ttaaaatctt      720

tggatacagg tgaagatatt gaaaaatatc ttgatgtaga ttctgtcctt aaaaatatag      780

caataaatac agctttatta aaccttgata gctatcaagg cagttttgcc cataactatt      840

atttatatga gcaagatgga gtattttcta tgttaccatg ggattttaat atgtcatttg      900

gtggatttag tggttttggt ggaggtagtc aatctatagc aattgatgaa cctacgacag      960

gtaatttaga agacagacct ctcatatcct cgttattaaa aaatgagaca cacaaaacaa     1020

aataccataa atatctggaa gagatagtaa caaaatacct agattcagac tatttagaga     1080

atatgacaac aaaattgcat gacatgatag catcatatgt aaaagaagac ccaacagcat     1140

tttatactta tgaagaattt gaaaaaaata taacatcttc aattgaagat tctagtgata     1200

ataagggatt tggtaataaa gggtttgaca acaataactc taataacagt gattctaata     1260

ataattctaa tagtgaaaat aagcgctctg gaaatcaaag tgataaaaaa gaagttaatg     1320

ctgaattaac atcaagcgta gtcaaaacta atacagataa tgaaactgaa aataaaacta     1380

caaatgatag cgaaagtaag aataatacag ataaagataa aagtggaaat gataataatc     1440

aaaagctaga aggtcctagg ggtaaaggag gtaagtcaat accaggggtt ttggaagttg     1500

cagaagatat gagtaaaact ataaaatctc aattaagtgg agaaacttct tcgacaaagc     1560

aaaactctgg tgatgaaagt tcaagtggaa ttaaaggtag tgaaaagttt gatgaggata     1620

tgagtggtat gccagaacca cctgagggaa tggatggtaa aatgccacca ggaatgggta     1680

atatggataa gggagatatg aatggtaaaa atggcaatat gaatatggat agaaatcaag     1740

ataatccaag agaagctgga ggttttggca atagaggagg aggctctgtg agtaaaacaa     1800

caacatactt caaattaatt ttaggtggag cttcaatgat aataatgtcg attatgttag     1860

taggtgtatc aagggtaaag agaagaagat ttataaagtc aaaataa                   1907


<210>  16
<211>  679
<212>  PRT
<213>  Clostridium difficile

<400>  16

Met Leu Ser Lys Glu Ile Asn Met Arg Arg Asn Thr Lys Leu Leu Thr 
1               5                   10                  15      


Thr Gly Ile Leu Ser Met Ala Ile Val Thr Pro Thr Met Ala Phe Ala 
            20                  25                  30          


Thr Glu Ser Asn Ala Met Glu Asn Asn Ala Asp Leu Asn Ile Asn Leu 
        35                  40                  45              


Glu Lys Lys Ser Ile Val Leu Gly Ser Thr Ser Lys Val Ser Val Lys 
    50                  55                  60                  


Phe Lys Glu Lys Pro Asp Ala Asp Ser Ile Thr Leu Lys Tyr Lys Cys 
65                  70                  75                  80  


Tyr Asp Met Pro Leu Asp Thr Thr Leu Asn Tyr Asn Gln Ser Thr Glu 
                85                  90                  95      


Ser Tyr Glu Gly Thr Ile Asn Tyr Asn Lys Asp Pro Glu Tyr Leu Asn 
            100                 105                 110         


Val Trp Glu Leu Gln Gly Ile Thr Ile Asn Ser Lys Asn Asn Pro Lys 
        115                 120                 125             


Thr Leu Asn Lys Gln Glu Leu Glu Lys Met Gly Leu Asn Leu Lys Asp 
    130                 135                 140                 


Tyr Asn Val Thr Gln Glu Cys Ile Ile Glu Asp Ile Thr Ser Arg Lys 
145                 150                 155                 160 


Asp Val Asn Lys Tyr Leu Arg Lys Thr Ser Ala Pro Ile Thr Glu Leu 
                165                 170                 175     


Thr Gly Ser Asp Arg Tyr Glu Thr Ala Val Lys Ile Ser Lys Glu Gly 
            180                 185                 190         


Trp Lys Asn Gly Ser Asp Lys Val Val Ile Ile Asn Gly Asp Val Ser 
        195                 200                 205             


Ile Asp Gly Ile Ile Ser Thr Pro Leu Ala Thr Thr Tyr Asn Ala Pro 
    210                 215                 220                 


Ile Leu Leu Val Glu Lys Asn Asn Val Pro Asn Ser Val Lys Ser Glu 
225                 230                 235                 240 


Leu Lys Arg Leu Asn Pro Arg Asp Val Ile Ile Ile Gly Asp Glu Asn 
                245                 250                 255     


Ala Ile Ser Lys Thr Thr Ala Asn Gln Ile Lys Ser Thr Val Asn Ala 
            260                 265                 270         


Ser Gln Thr Arg Leu Lys Gly Ser Asn Arg Tyr Glu Thr Ser Leu Leu 
        275                 280                 285             


Ile Ala Lys Glu Ile Asp Lys Asn His Asp Val Glu Lys Val Tyr Ile 
    290                 295                 300                 


Thr Asn Ala Asn Gly Gly Glu Val Asp Ala Leu Thr Ile Ala Ala Lys 
305                 310                 315                 320 


Ala Gly Gln Asp Lys Gln Pro Ile Ile Leu Thr Asp Lys Asn Ser Ile 
                325                 330                 335     


Thr Asp Asn Thr Tyr Lys Trp Leu Lys Ser Glu Asp Leu Gln Asn Ala 
            340                 345                 350         


Tyr Phe Ile Gly Gly Pro Gln Met Ile Ser Thr Asn Val Ile Asn Lys 
        355                 360                 365             


Val Asn Asp Ile Thr Lys Asp Asn Val Thr Asn Asn Arg Val Tyr Gly 
    370                 375                 380                 


Ala Asp Arg His Glu Thr Asn Ala Asn Val Ile Lys Lys Phe Tyr Thr 
385                 390                 395                 400 


Asp Asp Glu Leu Glu Ala Val Leu Val Ala Lys Ser Asp Val Leu Val 
                405                 410                 415     


Asp Ala Leu Ala Ala Gly Pro Leu Ala Ala Asn Leu Lys Ser Pro Ile 
            420                 425                 430         


Leu Ile Thr Pro Lys Thr Tyr Val Ser Ala Tyr His Lys Glu Asn Leu 
        435                 440                 445             


Glu Ala Lys Ser Ala Asn Lys Val Tyr Lys Ile Gly Gly Gly Leu Thr 
    450                 455                 460                 


Ser Lys Val Met Ser Ser Ile Ala Ser Ser Leu Ser Lys His Asn Thr 
465                 470                 475                 480 


Thr Pro Thr Glu Pro Gly Asn Ser Gly Gly Lys Thr Val Met Ile Asp 
                485                 490                 495     


Pro Gly His Gly Gly Ser Asp Thr Gly Thr Thr Gly Lys Pro Leu Gly 
            500                 505                 510         


Gly Ile Arg Glu Lys Asp Tyr Thr Leu Asn Thr Ser Leu Ala Thr Thr 
        515                 520                 525             


Glu Tyr Leu Arg Ser Lys Gly Phe Asn Val Ile Met Thr Arg Asp Thr 
    530                 535                 540                 


Asp Lys Thr Leu Ser Leu Gly Asn Arg Thr Ala Leu Ser Asn Ser Leu 
545                 550                 555                 560 


Arg Pro Asp Leu Phe Thr Ser Ile His Tyr Asn Ala Ser Asp Thr Thr 
                565                 570                 575     


Gly Asn Gly Val Glu Val Phe Tyr Lys Leu Lys Asp Lys Asp Gly Gly 
            580                 585                 590         


Thr Thr Lys Thr Val Ala Thr Asn Ile Leu Asn Arg Ile Leu Glu Lys 
        595                 600                 605             


Phe Asn Leu Lys Asn Arg Gly Ala Lys Thr Arg Thr Leu Ser Thr Asp 
    610                 615                 620                 


Pro Thr Lys Asp Tyr Leu Tyr Val Leu Arg Asn Asn Asp Met Pro Ala 
625                 630                 635                 640 


Val Leu Val Glu Cys Ala Phe Leu Asp Asn Glu Lys Asp Met Ser Leu 
                645                 650                 655     


Leu Asn Thr Ser Asn Lys Val Lys Glu Met Gly Thr Gln Ile Gly Lys 
            660                 665                 670         


Gly Ile Glu Asp Ser Leu Lys 
        675                 


<210>  17
<211>  675
<212>  PRT
<213>  Clostridium difficile

<400>  17

Met Met Lys Lys Thr Thr Lys Leu Leu Ala Thr Gly Met Leu Ser Val 
1               5                   10                  15      


Ala Met Val Ala Pro Asn Val Ala Leu Ala Ala Glu Asn Thr Thr Ala 
            20                  25                  30          


Asn Thr Glu Ser Asn Ser Asp Ile Asn Ile Asn Leu Gln Arg Lys Ser 
        35                  40                  45              


Val Val Leu Gly Ser Lys Ser Asn Ala Ser Val Lys Phe Lys Glu Lys 
    50                  55                  60                  


Leu Asn Ala Asp Ser Ile Thr Leu Asn Phe Met Cys Tyr Asp Met Pro 
65                  70                  75                  80  


Leu Glu Ala Thr Leu Asn Tyr Asn Glu Lys Thr Asp Ser Tyr Glu Gly 
                85                  90                  95      


Val Ile Asn Tyr Asn Lys Asp Pro Glu Tyr Leu Asn Val Trp Glu Leu 
            100                 105                 110         


Gln Ser Ile Lys Ile Asn Gly Lys Asp Glu Gln Lys Val Leu Asn Lys 
        115                 120                 125             


Glu Asp Leu Glu Ser Met Gly Leu Asn Leu Lys Asp Tyr Asp Val Thr 
    130                 135                 140                 


Gln Glu Phe Ile Ile Ser Asp Ala Asn Ser Thr Lys Ala Val Asn Glu 
145                 150                 155                 160 


Tyr Met Arg Lys Thr Ser Ala Pro Val Lys Lys Leu Ala Gly Ala Thr 
                165                 170                 175     


Arg Phe Glu Thr Ala Val Glu Ile Ser Lys Gln Gly Trp Lys Asp Gly 
            180                 185                 190         


Ser Ser Lys Val Val Ile Val Asn Gly Glu Leu Ala Ala Asp Gly Ile 
        195                 200                 205             


Thr Ala Thr Pro Leu Ala Ser Thr Tyr Asp Ala Pro Ile Leu Leu Ala 
    210                 215                 220                 


Asn Lys Asp Asp Ile Pro Glu Ser Thr Lys Ala Glu Leu Lys Arg Leu 
225                 230                 235                 240 


Asn Pro Ser Asp Val Ile Ile Ile Gly Asp Asp Gly Ser Val Ser Gln 
                245                 250                 255     


Lys Ala Val Ser Gln Ile Lys Ser Ala Val Asn Val Asn Val Thr Arg 
            260                 265                 270         


Ile Gly Gly Val Asp Arg His Glu Thr Ser Leu Leu Ile Ala Lys Glu 
        275                 280                 285             


Ile Asp Lys Tyr His Asp Val Asn Lys Ile Tyr Ile Ala Asn Gly Tyr 
    290                 295                 300                 


Ala Gly Glu Tyr Asp Ala Leu Asn Ile Ser Ser Lys Ala Gly Glu Asp 
305                 310                 315                 320 


Gln Gln Pro Ile Ile Leu Ala Asn Lys Asp Ser Val Pro Gln Gly Thr 
                325                 330                 335     


Tyr Asn Trp Leu Ser Ser Gln Gly Leu Glu Glu Ala Tyr Tyr Ile Gly 
            340                 345                 350         


Gly Ser Gln Ser Leu Ser Ser Lys Ile Ile Asp Gln Ile Ser Lys Ile 
        355                 360                 365             


Ala Lys Asn Gly Thr Ser Lys Asn Arg Val Ser Gly Ala Asp Arg His 
    370                 375                 380                 


Glu Thr Asn Ala Asn Val Ile Lys Thr Phe Tyr Pro Asp Lys Glu Leu 
385                 390                 395                 400 


Ser Ala Met Leu Val Ala Lys Ser Asp Ile Ile Val Asp Ser Ile Thr 
                405                 410                 415     


Ala Gly Pro Leu Ala Ala Lys Leu Lys Ala Pro Ile Leu Ile Thr Pro 
            420                 425                 430         


Lys Thr Tyr Val Ser Ala Tyr His Ser Thr Asn Leu Ser Glu Lys Thr 
        435                 440                 445             


Ala Glu Thr Val Tyr Gln Ile Gly Asp Gly Met Lys Asp Ser Val Ile 
    450                 455                 460                 


Asn Ser Ile Ala Ser Ser Leu Ser Lys His Asn Ala Pro Thr Glu Pro 
465                 470                 475                 480 


Asp Asn Ser Gly Ser Ala Ala Gly Lys Thr Val Val Ile Asp Pro Gly 
                485                 490                 495     


His Gly Gly Ser Asp Ser Gly Ala Thr Ser Gly Leu Asn Gly Gly Ala 
            500                 505                 510         


Gln Glu Lys Lys Tyr Thr Leu Asn Thr Ala Leu Ala Thr Thr Glu Tyr 
        515                 520                 525             


Leu Arg Ser Lys Gly Ile Asn Val Val Met Thr Arg Asp Thr Asp Lys 
    530                 535                 540                 


Thr Met Ala Leu Gly Glu Arg Thr Ala Leu Ser Asn Thr Ile Lys Pro 
545                 550                 555                 560 


Asp Leu Phe Thr Ser Ile His Tyr Asn Ala Ser Asn Gly Ser Gly Asn 
                565                 570                 575     


Gly Val Glu Ile Tyr Tyr Lys Val Lys Asp Lys Asn Gly Gly Thr Thr 
            580                 585                 590         


Lys Thr Ala Ala Ser Asn Ile Leu Lys Arg Ile Leu Glu Lys Phe Asn 
        595                 600                 605             


Met Lys Asn Arg Gly Ile Lys Thr Arg Thr Leu Asp Asn Gly Lys Asp 
    610                 615                 620                 


Tyr Leu Tyr Val Leu Arg Asn Asn Asn Tyr Pro Ala Ile Leu Val Glu 
625                 630                 635                 640 


Cys Ala Phe Ile Asp Asn Lys Ser Asp Met Asp Lys Leu Asn Thr Ala 
                645                 650                 655     


Glu Lys Val Lys Thr Met Gly Thr Gln Ile Gly Ile Gly Ile Glu Asp 
            660                 665                 670         


Thr Val Lys 
        675 


<210>  18
<211>  618
<212>  PRT
<213>  Clostridium difficile

<400>  18

Met Phe Arg Phe Lys Glu Lys Pro Asp Ala Asp Ser Ile Thr Leu Lys 
1               5                   10                  15      


Tyr Lys Cys Tyr Asp Met Pro Leu Asp Thr Thr Leu Asn Tyr Asn Gln 
            20                  25                  30          


Ser Thr Glu Ser Tyr Glu Gly Thr Ile Asn Tyr Asn Lys Asp Pro Glu 
        35                  40                  45              


Tyr Leu Asn Val Trp Glu Leu Gln Gly Ile Thr Ile Asn Ser Lys Asn 
    50                  55                  60                  


Asn Pro Lys Thr Leu Asn Lys Gln Glu Leu Glu Lys Met Gly Leu Asn 
65                  70                  75                  80  


Leu Lys Asp Tyr Asn Val Thr Gln Glu Cys Ile Ile Glu Asp Ile Thr 
                85                  90                  95      


Ser Arg Lys Asp Val Asn Lys Tyr Leu Arg Lys Thr Ser Ala Pro Ile 
            100                 105                 110         


Thr Glu Leu Thr Gly Ser Asp Arg Tyr Glu Thr Ala Val Lys Ile Ser 
        115                 120                 125             


Lys Glu Gly Trp Lys Asn Gly Ser Asp Lys Val Val Ile Ile Asn Gly 
    130                 135                 140                 


Asp Val Ser Ile Asp Gly Ile Ile Ser Thr Pro Leu Ala Thr Thr Tyr 
145                 150                 155                 160 


Asn Ala Pro Ile Leu Leu Val Glu Lys Asn Asn Val Pro Asn Ser Val 
                165                 170                 175     


Lys Ser Glu Leu Lys Arg Leu Asn Pro Arg Asp Val Ile Ile Ile Gly 
            180                 185                 190         


Asp Glu Asn Ala Ile Ser Lys Thr Thr Ala Asn Gln Ile Lys Ser Thr 
        195                 200                 205             


Val Asn Ala Ser Gln Thr Arg Leu Lys Gly Ser Asn Arg Tyr Glu Thr 
    210                 215                 220                 


Ser Leu Leu Ile Ala Lys Glu Ile Asp Lys Asn His Asp Val Glu Lys 
225                 230                 235                 240 


Val Tyr Ile Thr Asn Ala Asn Gly Gly Glu Val Asp Ala Leu Thr Ile 
                245                 250                 255     


Ala Ala Lys Ala Gly Gln Asp Lys Gln Pro Ile Ile Leu Thr Asp Lys 
            260                 265                 270         


Asn Ser Ile Thr Asp Asn Thr Tyr Lys Trp Leu Lys Ser Glu Asp Leu 
        275                 280                 285             


Gln Asn Ala Tyr Phe Ile Gly Gly Pro Gln Met Ile Ser Thr Asn Val 
    290                 295                 300                 


Ile Asn Lys Val Asn Asp Ile Thr Lys Asp Asn Val Thr Asn Asn Arg 
305                 310                 315                 320 


Val Tyr Gly Ala Asp Arg His Glu Thr Asn Ala Asn Val Ile Lys Lys 
                325                 330                 335     


Phe Tyr Thr Asp Asp Glu Leu Glu Ala Val Leu Val Ala Lys Ser Asp 
            340                 345                 350         


Val Leu Val Asp Ala Leu Ala Ala Gly Pro Leu Ala Ala Asn Leu Lys 
        355                 360                 365             


Ser Pro Ile Leu Ile Thr Pro Lys Thr Tyr Val Ser Ala Tyr His Lys 
    370                 375                 380                 


Asp Asn Leu Glu Ala Lys Ser Ala Asn Lys Val Tyr Lys Ile Gly Gly 
385                 390                 395                 400 


Gly Leu Thr Ser Lys Val Met Asn Ser Ile Ala Ser Ser Leu Ser Lys 
                405                 410                 415     


His Asn Thr Thr Pro Thr Glu Pro Gly Asn Ser Gly Gly Lys Thr Val 
            420                 425                 430         


Met Ile Asp Pro Gly His Gly Gly Ser Asp Thr Gly Thr Thr Gly Lys 
        435                 440                 445             


Pro Leu Gly Gly Ile Lys Glu Lys Asp Tyr Thr Leu Asn Thr Ser Leu 
    450                 455                 460                 


Ala Thr Thr Glu Tyr Leu Arg Ser Lys Gly Phe Asn Val Ile Met Thr 
465                 470                 475                 480 


Arg Asp Thr Asp Lys Thr Leu Ser Leu Gly Asn Arg Thr Ala Leu Ser 
                485                 490                 495     


Asn Ser Leu Arg Pro Asp Leu Phe Thr Ser Ile His Tyr Asn Ala Ser 
            500                 505                 510         


Asp Thr Thr Gly Asn Gly Val Glu Val Phe Tyr Lys Leu Lys Asp Lys 
        515                 520                 525             


Asp Gly Gly Thr Thr Lys Thr Val Ala Thr Asn Ile Leu Asn Arg Ile 
    530                 535                 540                 


Leu Glu Lys Phe Asn Leu Lys Asn Arg Gly Ala Lys Thr Arg Thr Leu 
545                 550                 555                 560 


Ser Thr Asp Pro Thr Lys Asp Tyr Leu Tyr Val Leu Arg Asn Asn Asp 
                565                 570                 575     


Met Pro Ala Val Leu Val Glu Cys Ala Phe Leu Asp Asn Glu Lys Asp 
            580                 585                 590         


Met Ser Leu Leu Asn Thr Ser Asn Lys Val Lys Glu Met Gly Thr Gln 
        595                 600                 605             


Ile Gly Lys Gly Ile Glu Asp Ser Leu Lys 
    610                 615             


<210>  19
<211>  552
<212>  PRT
<213>  Clostridium difficile

<400>  19

Met Leu Ser Lys Glu Ile Asn Met Arg Arg Asn Thr Lys Leu Leu Thr 
1               5                   10                  15      


Thr Gly Ile Leu Ser Met Ala Ile Val Ala Pro Thr Met Ala Phe Ala 
            20                  25                  30          


Thr Glu Ser Asn Ala Met Glu Asn Asn Ala Asp Leu Asn Ile Asn Leu 
        35                  40                  45              


Glu Lys Lys Ser Ile Val Leu Gly Ser Lys Ser Lys Val Ser Val Lys 
    50                  55                  60                  


Phe Lys Glu Lys Pro Asp Ala Asp Ser Ile Thr Leu Lys Tyr Lys Cys 
65                  70                  75                  80  


Tyr Asp Met Pro Leu Asp Thr Thr Leu Asn Tyr Asn Gln Ser Thr Gly 
                85                  90                  95      


Ala Tyr Glu Gly Thr Ile Asn Tyr Asn Gln Asp Pro Glu Tyr Leu Asn 
            100                 105                 110         


Val Trp Glu Leu Gln Gly Ile Thr Ile Asn Ser Lys Asn Asn Pro Lys 
        115                 120                 125             


Thr Leu Asn Gly Gln Asp Leu Glu Lys Met Gly Leu Asn Leu Lys Asp 
    130                 135                 140                 


Tyr Asn Val Thr Gln Glu Cys Ile Ile Glu Asp Ile Thr Ser Arg Lys 
145                 150                 155                 160 


Asp Val Asn Lys Tyr Leu Arg Lys Thr Ser Ala Pro Ile Thr Glu Leu 
                165                 170                 175     


Thr Gly Ser Asp Arg Tyr Glu Thr Ala Val Lys Ile Ser Lys Glu Gly 
            180                 185                 190         


Trp Lys Asn Gly Ser Asp Lys Val Val Ile Ile Asn Gly Asp Val Ser 
        195                 200                 205             


Ile Asp Gly Ile Ile Ser Thr Pro Leu Ala Thr Thr Tyr Asn Ala Pro 
    210                 215                 220                 


Ile Leu Leu Val Glu Lys Asn Asn Val Pro Asn Ser Val Lys Ser Glu 
225                 230                 235                 240 


Leu Lys Arg Leu Asn Pro Lys Asp Ile Ile Ile Ile Gly Asp Glu Asn 
                245                 250                 255     


Ala Ile Ser Lys Thr Thr Ala Asn Gln Ile Lys Ser Thr Val Asn Ala 
            260                 265                 270         


Ser Gln Thr Arg Leu Asn Gly Ser Asn Arg Tyr Glu Thr Ser Leu Leu 
        275                 280                 285             


Ile Ala Lys Glu Ile Asp Lys Asn His Asp Val Glu Lys Val Tyr Ile 
    290                 295                 300                 


Thr Asn Ala Asn Gly Gly Glu Val Asp Ala Leu Thr Ile Ala Ala Lys 
305                 310                 315                 320 


Ala Gly Gln Asp Lys Gln Pro Ile Ile Leu Thr Asp Lys Asp Ser Ile 
                325                 330                 335     


Thr Asp Asn Thr Tyr Lys Trp Leu Lys Ser Glu Asp Leu Gln Asn Ala 
            340                 345                 350         


Tyr Phe Ile Gly Gly Pro Gln Met Ile Ser Thr Asn Val Ile Asn Lys 
        355                 360                 365             


Val Asn Gly Ile Thr Lys Asp Ser Val Thr Asn Asn Arg Val Tyr Gly 
    370                 375                 380                 


Ala Asp Arg His Glu Thr Asn Ala Asn Val Ile Lys Lys Phe Tyr Thr 
385                 390                 395                 400 


Glu Asp Glu Ile Glu Ala Val Leu Val Ala Lys Ser Asp Val Leu Val 
                405                 410                 415     


Asp Ala Leu Ala Ala Gly Pro Leu Ala Ala Asn Leu Lys Ser Pro Ile 
            420                 425                 430         


Leu Ile Thr Pro Lys Thr Tyr Val Ser Ala Tyr His Lys Asp Asn Leu 
        435                 440                 445             


Glu Ala Lys Ser Ala Asn Lys Val Tyr Lys Ile Gly Gly Gly Leu Thr 
    450                 455                 460                 


Ser Lys Val Met Ser Ser Ile Ala Ser Ser Leu Ser Lys His Asn Thr 
465                 470                 475                 480 


Thr Pro Thr Glu Pro Gly Asn Ser Gly Gly Lys Thr Val Met Ile Asp 
                485                 490                 495     


Pro Gly His Gly Gly Ser Ala Pro Gly Asn Ser Ser Gly Gly Met Ile 
            500                 505                 510         


Glu Lys Asp Tyr Asn Leu Asn Thr Ser Leu Ala Thr Thr Glu Tyr Leu 
        515                 520                 525             


Arg Ser Lys Gly Phe Asn Val Ile Met Thr Arg Asp Thr Asp Lys Thr 
    530                 535                 540                 


Leu Ser Leu Gly Asn Arg Thr Ala 
545                 550         


<210>  20
<211>  675
<212>  PRT
<213>  Clostridium difficile

<400>  20

Met Met Lys Lys Thr Thr Lys Leu Leu Ala Thr Gly Met Leu Ser Val 
1               5                   10                  15      


Ala Met Val Ala Pro Asn Val Ala Leu Ala Ala Glu Asn Thr Thr Ala 
            20                  25                  30          


Asn Thr Glu Ser Asn Ser Asp Ile Asn Ile Asn Leu Gln Arg Lys Ser 
        35                  40                  45              


Val Val Leu Gly Ser Lys Ser Asn Ala Ser Val Lys Phe Lys Glu Lys 
    50                  55                  60                  


Leu Asn Ala Asp Ser Ile Thr Leu Asn Phe Met Cys Tyr Asp Met Pro 
65                  70                  75                  80  


Leu Glu Ala Thr Leu Asn Tyr Asn Glu Lys Thr Asp Ser Tyr Glu Gly 
                85                  90                  95      


Val Ile Asn Tyr Asn Lys Asp Pro Glu Tyr Leu Asn Val Trp Glu Leu 
            100                 105                 110         


Gln Ser Ile Lys Ile Asn Gly Lys Asp Glu Gln Lys Val Leu Asn Lys 
        115                 120                 125             


Glu Asp Leu Glu Ser Met Gly Leu Asn Leu Lys Asp Tyr Asp Val Thr 
    130                 135                 140                 


Gln Glu Phe Ile Ile Ser Asp Ala Asn Ser Thr Lys Ala Val Asn Glu 
145                 150                 155                 160 


Tyr Met Arg Lys Thr Ser Ala Pro Val Lys Lys Leu Ala Gly Ala Thr 
                165                 170                 175     


Arg Phe Glu Thr Ala Val Glu Ile Ser Lys Gln Gly Trp Lys Asp Gly 
            180                 185                 190         


Ser Ser Lys Val Val Ile Val Asn Gly Glu Leu Ala Ala Asp Gly Ile 
        195                 200                 205             


Thr Ala Thr Pro Leu Ala Ser Thr Tyr Asp Ala Pro Ile Leu Leu Ala 
    210                 215                 220                 


Asn Lys Asp Asp Ile Pro Glu Ser Thr Lys Ala Glu Leu Lys Arg Leu 
225                 230                 235                 240 


Asn Pro Ser Asp Val Ile Ile Ile Gly Asp Asp Gly Ser Val Ser Gln 
                245                 250                 255     


Lys Ala Val Ser Gln Ile Lys Ser Ala Val Asn Val Asn Val Thr Arg 
            260                 265                 270         


Ile Gly Gly Val Asp Arg His Glu Thr Ser Leu Leu Ile Ala Lys Glu 
        275                 280                 285             


Ile Asp Lys Tyr His Asp Val Asn Lys Ile Tyr Ile Ala Asn Gly Tyr 
    290                 295                 300                 


Ala Gly Glu Tyr Asp Ala Leu Asn Ile Ser Ser Lys Ala Gly Glu Asp 
305                 310                 315                 320 


Gln Gln Pro Ile Ile Leu Ala Asn Lys Asp Ser Val Pro Gln Gly Thr 
                325                 330                 335     


Tyr Asn Trp Leu Ser Ser Gln Gly Leu Glu Glu Ala Tyr Tyr Ile Gly 
            340                 345                 350         


Gly Ser Gln Ser Leu Ser Ser Lys Ile Ile Asp Gln Ile Ser Lys Ile 
        355                 360                 365             


Ala Lys Asn Gly Thr Ser Lys Asn Arg Val Ser Gly Ala Asp Arg His 
    370                 375                 380                 


Glu Thr Asn Ala Asn Val Ile Lys Thr Phe Tyr Pro Asp Lys Glu Leu 
385                 390                 395                 400 


Ser Ala Met Leu Val Ala Lys Ser Asp Ile Ile Val Asp Ser Ile Thr 
                405                 410                 415     


Ala Gly Pro Leu Ala Ala Lys Leu Lys Ala Pro Ile Leu Ile Thr Pro 
            420                 425                 430         


Lys Thr Tyr Val Ser Ala Tyr His Ser Thr Asn Leu Ser Glu Lys Thr 
        435                 440                 445             


Ala Gly Thr Val Tyr Gln Ile Gly Asp Gly Met Lys Asp Ser Val Ile 
    450                 455                 460                 


Asn Ser Ile Ala Ser Ser Leu Ser Lys His Asn Ala Pro Thr Glu Pro 
465                 470                 475                 480 


Asp Asn Ser Gly Ser Ala Ala Gly Lys Thr Val Val Ile Asp Pro Gly 
                485                 490                 495     


His Gly Gly Ser Asp Ser Gly Ala Thr Ser Gly Leu Asn Gly Gly Ala 
            500                 505                 510         


Gln Glu Lys Lys Tyr Thr Leu Asn Thr Ala Leu Ala Thr Thr Glu Tyr 
        515                 520                 525             


Leu Arg Ser Lys Gly Ile Asn Val Val Met Thr Arg Asp Thr Asp Lys 
    530                 535                 540                 


Thr Met Ala Leu Gly Glu Arg Thr Ala Leu Ser Asn Thr Ile Lys Pro 
545                 550                 555                 560 


Asp Leu Phe Thr Ser Ile His Tyr Asn Ala Ser Asn Gly Ala Gly Asn 
                565                 570                 575     


Gly Val Glu Ile Tyr Tyr Lys Val Lys Asp Lys Asn Gly Gly Thr Thr 
            580                 585                 590         


Lys Thr Ala Ala Ser Asn Ile Leu Lys Arg Ile Leu Glu Lys Phe Asn 
        595                 600                 605             


Met Lys Asn Arg Gly Ile Lys Thr Arg Thr Leu Asp Asn Gly Lys Asp 
    610                 615                 620                 


Tyr Leu Tyr Val Leu Arg Asn Asn Asn Tyr Pro Ala Ile Leu Val Glu 
625                 630                 635                 640 


Cys Ala Phe Ile Asp Asn Lys Ser Asp Met Asp Lys Leu Asn Thr Ala 
                645                 650                 655     


Glu Lys Val Lys Thr Met Gly Thr Gln Ile Gly Ile Gly Ile Glu Asp 
            660                 665                 670         


Thr Val Lys 
        675 


<210>  21
<211>  333
<212>  PRT
<213>  Clostridium difficile

<400>  21

Lys Ile Lys Lys Phe Thr Leu Leu Ile Ser Ile Met Ile Ile Phe Leu 
1               5                   10                  15      


Cys Ala Val Val Gly Val Tyr Ser Thr Ser Ser Asn Lys Ser Val Asp 
            20                  25                  30          


Leu Tyr Ser Asp Val Tyr Ile Glu Lys Tyr Phe Asn Arg Asp Lys Val 
        35                  40                  45              


Met Glu Val Asn Ile Glu Ile Asp Glu Ser Asp Leu Lys Asp Met Asn 
    50                  55                  60                  


Glu Asn Ala Ile Lys Glu Glu Phe Lys Val Ala Lys Val Thr Val Asp 
65                  70                  75                  80  


Gly Asp Thr Tyr Gly Asn Val Gly Ile Arg Thr Lys Gly Asn Ser Ser 
                85                  90                  95      


Leu Thr Ser Val Ala Asn Ser Asp Ser Asp Arg Tyr Ser Tyr Lys Ile 
            100                 105                 110         


Asn Phe Asp Lys Tyr Asn Thr Ser Gln Ser Met Glu Gly Leu Thr Gln 
        115                 120                 125             


Leu Asn Leu Asn Asn Cys Tyr Ser Asp Pro Ser Tyr Met Arg Glu Phe 
    130                 135                 140                 


Leu Thr Tyr Ser Ile Cys Glu Glu Met Gly Leu Ala Thr Pro Glu Phe 
145                 150                 155                 160 


Ala Tyr Ala Lys Val Ser Ile Asn Gly Glu Tyr His Gly Leu Tyr Leu 
                165                 170                 175     


Ala Val Glu Gly Leu Lys Glu Ser Tyr Leu Glu Asn Asn Phe Gly Asn 
            180                 185                 190         


Val Thr Gly Asp Leu Tyr Lys Ser Asp Glu Gly Ser Ser Leu Gln Tyr 
        195                 200                 205             


Lys Gly Asp Asp Pro Glu Ser Tyr Ser Asn Leu Ile Val Glu Ser Asp 
    210                 215                 220                 


Lys Lys Thr Ala Asp Trp Ser Lys Ile Thr Lys Leu Leu Lys Ser Leu 
225                 230                 235                 240 


Asp Thr Gly Glu Asp Ile Glu Lys Tyr Leu Asp Val Asp Ser Val Leu 
                245                 250                 255     


Lys Asn Ile Ala Ile Asn Thr Ala Leu Leu Asn Leu Asp Ser Tyr Gln 
            260                 265                 270         


Gly Ser Phe Ala His Asn Tyr Tyr Leu Tyr Glu Gln Asp Gly Val Phe 
        275                 280                 285             


Ser Met Leu Pro Trp Asp Phe Asn Met Ser Phe Gly Gly Phe Ser Gly 
    290                 295                 300                 


Phe Gly Gly Gly Ser Gln Ser Ile Ala Ile Asp Glu Pro Thr Thr Gly 
305                 310                 315                 320 


Asn Leu Glu Asp Arg Pro Leu Ile Ser Ser Leu Leu Lys 
                325                 330             


<210>  22
<211>  302
<212>  PRT
<213>  Clostridium difficile

<400>  22

Lys Asn Glu Thr His Lys Thr Lys Tyr His Lys Tyr Leu Glu Glu Ile 
1               5                   10                  15      


Val Thr Lys Tyr Leu Asp Ser Asp Tyr Leu Glu Asn Met Thr Thr Lys 
            20                  25                  30          


Leu His Asp Met Ile Ala Ser Tyr Val Lys Glu Asp Pro Thr Ala Phe 
        35                  40                  45              


Tyr Thr Tyr Glu Glu Phe Glu Lys Asn Ile Thr Ser Ser Ile Glu Asp 
    50                  55                  60                  


Ser Ser Asp Asn Lys Gly Phe Gly Asn Lys Gly Phe Asp Asn Asn Asn 
65                  70                  75                  80  


Ser Asn Asn Ser Asp Ser Asn Asn Asn Ser Asn Ser Glu Asn Lys Arg 
                85                  90                  95      


Ser Gly Asn Gln Ser Asp Lys Lys Glu Val Asn Ala Glu Leu Thr Ser 
            100                 105                 110         


Ser Val Val Lys Thr Asn Thr Asp Asn Glu Thr Glu Asn Lys Thr Thr 
        115                 120                 125             


Asn Asp Ser Glu Ser Lys Asn Asn Thr Asp Lys Asp Lys Ser Gly Asn 
    130                 135                 140                 


Asp Asn Asn Gln Lys Leu Glu Gly Pro Arg Gly Lys Gly Gly Lys Ser 
145                 150                 155                 160 


Ile Pro Gly Val Leu Glu Val Ala Glu Asp Met Ser Lys Thr Ile Lys 
                165                 170                 175     


Ser Gln Leu Ser Gly Glu Thr Ser Ser Thr Lys Gln Asn Ser Gly Asp 
            180                 185                 190         


Glu Ser Ser Ser Gly Ile Lys Gly Ser Glu Lys Phe Asp Glu Asp Met 
        195                 200                 205             


Ser Gly Met Pro Glu Pro Pro Glu Gly Met Asp Gly Lys Met Pro Pro 
    210                 215                 220                 


Gly Met Gly Asn Met Asp Lys Gly Asp Met Asn Gly Lys Asn Gly Asn 
225                 230                 235                 240 


Met Asn Met Asp Arg Asn Gln Asp Asn Pro Arg Glu Ala Gly Gly Phe 
                245                 250                 255     


Gly Asn Arg Gly Gly Gly Ser Val Ser Lys Thr Thr Thr Tyr Phe Lys 
            260                 265                 270         


Leu Ile Leu Gly Gly Ala Ser Met Ile Ile Met Ser Ile Met Leu Val 
        275                 280                 285             


Gly Val Ser Arg Val Lys Arg Arg Arg Phe Ile Lys Ser Lys 
    290                 295                 300         


<210>  23
<211>  635
<212>  PRT
<213>  Clostridium difficile

<400>  23

Met Lys Asp Lys Lys Phe Thr Leu Leu Ile Ser Ile Met Ile Ile Phe 
1               5                   10                  15      


Leu Cys Ala Val Val Gly Val Tyr Ser Thr Ser Ser Asn Lys Ser Val 
            20                  25                  30          


Asp Leu Tyr Ser Asp Val Tyr Ile Glu Lys Tyr Phe Asn Arg Asp Lys 
        35                  40                  45              


Val Met Glu Val Asn Ile Glu Ile Asp Glu Ser Asp Leu Lys Asp Met 
    50                  55                  60                  


Asn Glu Asn Ala Ile Lys Glu Glu Phe Lys Val Ala Lys Val Thr Val 
65                  70                  75                  80  


Asp Gly Asp Thr Tyr Gly Asn Val Gly Ile Arg Thr Lys Gly Asn Ser 
                85                  90                  95      


Ser Leu Thr Ser Val Ala Asn Ser Asp Ser Asp Arg Tyr Ser Tyr Lys 
            100                 105                 110         


Ile Asn Phe Asp Lys Tyr Asn Thr Ser Gln Ser Met Glu Gly Leu Thr 
        115                 120                 125             


Gln Leu Asn Leu Asn Asn Cys Tyr Ser Asp Pro Ser Tyr Met Arg Glu 
    130                 135                 140                 


Phe Leu Thr Tyr Ser Ile Cys Glu Glu Met Gly Leu Ala Thr Pro Glu 
145                 150                 155                 160 


Phe Ala Tyr Ala Lys Val Ser Ile Asn Gly Glu Tyr His Gly Leu Tyr 
                165                 170                 175     


Leu Ala Val Glu Gly Leu Lys Glu Ser Tyr Leu Glu Asn Asn Phe Gly 
            180                 185                 190         


Asn Val Thr Gly Asp Leu Tyr Lys Ser Asp Glu Gly Ser Ser Leu Gln 
        195                 200                 205             


Tyr Lys Gly Asp Asp Pro Glu Ser Tyr Ser Asn Leu Ile Val Glu Ser 
    210                 215                 220                 


Asp Lys Lys Thr Ala Asp Trp Ser Lys Ile Thr Lys Leu Leu Lys Ser 
225                 230                 235                 240 


Leu Asp Thr Gly Glu Asp Ile Glu Lys Tyr Leu Asp Val Asp Ser Val 
                245                 250                 255     


Leu Lys Asn Ile Ala Ile Asn Thr Ala Leu Leu Asn Leu Asp Ser Tyr 
            260                 265                 270         


Gln Gly Ser Phe Ala His Asn Tyr Tyr Leu Tyr Glu Gln Asp Gly Val 
        275                 280                 285             


Phe Ser Met Leu Pro Trp Asp Phe Asn Met Ser Phe Gly Gly Phe Ser 
    290                 295                 300                 


Gly Phe Gly Gly Gly Ser Gln Ser Ile Ala Ile Asp Glu Pro Thr Thr 
305                 310                 315                 320 


Gly Asn Leu Glu Asp Arg Pro Leu Ile Ser Ser Leu Leu Lys Asn Glu 
                325                 330                 335     


Thr His Lys Thr Lys Tyr His Lys Tyr Leu Glu Glu Ile Val Thr Lys 
            340                 345                 350         


Tyr Leu Asp Ser Asp Tyr Leu Glu Asn Met Thr Thr Lys Leu His Asp 
        355                 360                 365             


Met Ile Ala Ser Tyr Val Lys Glu Asp Pro Thr Ala Phe Tyr Thr Tyr 
    370                 375                 380                 


Glu Glu Phe Glu Lys Asn Ile Thr Ser Ser Ile Glu Asp Ser Ser Asp 
385                 390                 395                 400 


Asn Lys Gly Phe Gly Asn Lys Gly Phe Asp Asn Asn Asn Ser Asn Asn 
                405                 410                 415     


Ser Asp Ser Asn Asn Asn Ser Asn Ser Glu Asn Lys Arg Ser Gly Asn 
            420                 425                 430         


Gln Ser Asp Lys Lys Glu Val Asn Ala Glu Leu Thr Ser Ser Val Val 
        435                 440                 445             


Lys Thr Asn Thr Asp Asn Glu Thr Glu Asn Lys Thr Thr Asn Asp Ser 
    450                 455                 460                 


Glu Ser Lys Asn Asn Thr Asp Lys Asp Lys Ser Gly Asn Asp Asn Asn 
465                 470                 475                 480 


Gln Lys Leu Glu Gly Pro Arg Gly Lys Gly Gly Lys Ser Ile Pro Gly 
                485                 490                 495     


Val Leu Glu Val Ala Glu Asp Met Ser Lys Thr Ile Lys Ser Gln Leu 
            500                 505                 510         


Ser Gly Glu Thr Ser Ser Thr Lys Gln Asn Ser Gly Asp Glu Ser Ser 
        515                 520                 525             


Ser Gly Ile Lys Gly Ser Glu Lys Phe Asp Glu Asp Met Ser Gly Met 
    530                 535                 540                 


Pro Glu Pro Pro Glu Gly Met Asp Gly Lys Met Pro Pro Gly Met Gly 
545                 550                 555                 560 


Asn Met Asp Lys Gly Asp Met Asn Gly Lys Asn Gly Asn Met Asn Met 
                565                 570                 575     


Asp Arg Asn Gln Asp Asn Pro Arg Glu Ala Gly Gly Phe Gly Asn Arg 
            580                 585                 590         


Gly Gly Gly Ser Val Ser Lys Thr Thr Thr Tyr Phe Lys Leu Ile Leu 
        595                 600                 605             


Gly Gly Ala Ser Met Ile Ile Met Ser Ile Met Leu Val Gly Val Ser 
    610                 615                 620                 


Arg Val Lys Arg Arg Arg Phe Ile Lys Ser Lys 
625                 630                 635 


<210>  24
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD1021 primer + restriction site

<400>  24
taagctagca tgaaagataa aaaatttacc                                        30


<210>  25
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD1021 primer + restriction site

<400>  25
ttactcgagt tttgacttta taaatcttct                                        30


<210>  26
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD1021 primer + restriction site

<400>  26
acagctagca tgaaaagtgt tgatttatat agt                                    33


<210>  27
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD1021 primer + restriction site

<400>  27
atcttcgaga gtattatact tatcaaaatt a                                      31


<210>  28
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD1021 primer + restriction site

<400>  28
aatgctagca tggtaactgg agacttatat aagtca                                 36


<210>  29
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD1021 primer + restriction site

<400>  29
aaactcgagt ggtaacatag aaaatactcc at                                     32


<210>  30
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD1021 primer + restriction site

<400>  30
gcagctagca tgagtaaaac tataaaatct caa                                    33


<210>  31
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD1021 primer + restriction site

<400>  31
aatctcgagg aagtatgttg ttgttttact cac                                    33


<210>  32
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD1021 primer + restriction site

<400>  32
gtaaaacgac ggccagt                                                      17


<210>  33
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD1021 primer + restriction site

<400>  33
caggaaacag ctatgac                                                      17


<210>  34
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD1036 + restriction site

<400>  34
aatccatggt aagtaaggag attaatatg                                         29


<210>  35
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD1036 primer + restriction site

<400>  35
ttcctcgagt tttaatgaat cttctattcc                                        30


<210>  36
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD1036 primer + restriction site

<400>  36
aggccatgga taaaaatcat gatgtggaa                                         29


<210>  37
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD1036 primer + restriction site

<400>  37
tttctcgagg tttgcatttg tttcgtgtct                                        30


<210>  38
<211>  635
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus protein sequence for CD1021


<220>
<221>  VARIANT
<222>  (1)..(12)
<223>  An "X" designates a residue where variants were observed among 
       the sequences (SEQ ID NOS: 1, 11, 12, 21, 22, 23) aligned in 
       Figure 1.  Variations included amino acid substitutions and/or 
       gaps between two or more sequences at the respective residues.

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  An "X" designates a residue where variants were observed among 
       the sequences (SEQ ID NOS: 1, 11, 12, 21, 22, 23) aligned in 
       Figure 1.  Variations included amino acid substitutions and/or 
       gaps between two or more sequences at residue 15.

<220>
<221>  VARIANT
<222>  (99)..(99)
<223>  An "X" designates a residue where variants were observed among 
       the sequences (SEQ ID NOS: 1, 11, 12, 21, 22, 23) aligned in 
       Figure 1.  Variations included amino acid substitutions and/or 
       gaps between two or more sequences at residue 99.

<220>
<221>  VARIANT
<222>  (334)..(361)
<223>  An "X" designates a residue where variants were observed among 
       the sequences (SEQ ID NOS: 1, 11, 12, 21, 22, 23) aligned in 
       Figure 1.  Variations included amino acid substitutions and/or 
       gaps between two or more sequences at the respective residues.

<400>  38

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Met Ile Xaa Phe 
1               5                   10                  15      


Leu Cys Ala Val Val Gly Val Tyr Ser Thr Ser Ser Asn Lys Ser Val 
            20                  25                  30          


Asp Leu Tyr Ser Asp Val Tyr Ile Glu Lys Tyr Phe Asn Arg Asp Lys 
        35                  40                  45              


Val Met Glu Val Asn Ile Glu Ile Asp Glu Ser Asp Leu Lys Asp Met 
    50                  55                  60                  


Asn Glu Asn Ala Ile Lys Glu Glu Phe Lys Val Ala Lys Val Thr Val 
65                  70                  75                  80  


Asp Gly Asp Thr Tyr Gly Asn Val Gly Ile Arg Thr Lys Gly Asn Ser 
                85                  90                  95      


Ser Leu Xaa Ser Val Ala Asn Ser Asp Ser Asp Arg Tyr Ser Tyr Lys 
            100                 105                 110         


Ile Asn Phe Asp Lys Tyr Asn Thr Ser Gln Ser Met Glu Gly Leu Thr 
        115                 120                 125             


Gln Leu Asn Leu Asn Asn Cys Tyr Ser Asp Pro Ser Tyr Met Arg Glu 
    130                 135                 140                 


Phe Leu Thr Tyr Ser Ile Cys Glu Glu Met Gly Leu Ala Thr Pro Glu 
145                 150                 155                 160 


Phe Ala Tyr Ala Lys Val Ser Ile Asn Gly Glu Tyr His Gly Leu Tyr 
                165                 170                 175     


Leu Ala Val Glu Gly Leu Lys Glu Ser Tyr Leu Glu Asn Asn Phe Gly 
            180                 185                 190         


Asn Val Thr Gly Asp Leu Tyr Lys Ser Asp Glu Gly Ser Ser Leu Gln 
        195                 200                 205             


Tyr Lys Gly Asp Asp Pro Glu Ser Tyr Ser Asn Leu Ile Val Glu Ser 
    210                 215                 220                 


Asp Lys Lys Thr Ala Asp Trp Ser Lys Ile Thr Lys Leu Leu Lys Ser 
225                 230                 235                 240 


Leu Asp Thr Gly Glu Asp Ile Glu Lys Tyr Leu Asp Val Asp Ser Val 
                245                 250                 255     


Leu Lys Asn Ile Ala Ile Asn Thr Ala Leu Leu Asn Leu Asp Ser Tyr 
            260                 265                 270         


Gln Gly Ser Phe Ala His Asn Tyr Tyr Leu Tyr Glu Gln Asp Gly Val 
        275                 280                 285             


Phe Ser Met Leu Pro Trp Asp Phe Asn Met Ser Phe Gly Gly Phe Ser 
    290                 295                 300                 


Gly Phe Gly Gly Gly Ser Gln Ser Ile Ala Ile Asp Glu Pro Thr Thr 
305                 310                 315                 320 


Gly Asn Leu Glu Asp Arg Pro Leu Ile Ser Ser Leu Leu Lys Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Met Thr Thr Lys Leu His Asp 
        355                 360                 365             


Met Ile Ala Ser Tyr Val Lys Glu Asp Pro Thr Ala Phe Tyr Thr Tyr 
    370                 375                 380                 


Glu Glu Phe Glu Lys Asn Ile Thr Ser Ser Ile Glu Asp Ser Ser Asp 
385                 390                 395                 400 


Asn Lys Gly Phe Gly Asn Lys Gly Phe Asp Asn Asn Asn Ser Asn Asn 
                405                 410                 415     


Ser Asp Ser Asn Asn Asn Ser Asn Ser Glu Asn Lys Arg Ser Gly Asn 
            420                 425                 430         


Gln Ser Asp Lys Lys Glu Val Asn Ala Glu Leu Thr Ser Ser Val Val 
        435                 440                 445             


Lys Thr Asn Thr Asp Asn Glu Thr Glu Asn Lys Thr Thr Asn Asp Ser 
    450                 455                 460                 


Glu Ser Lys Asn Asn Thr Asp Lys Asp Lys Ser Gly Asn Asp Asn Asn 
465                 470                 475                 480 


Gln Lys Leu Glu Gly Pro Arg Gly Lys Gly Gly Lys Ser Ile Pro Gly 
                485                 490                 495     


Val Leu Glu Val Ala Glu Asp Met Ser Lys Thr Ile Lys Ser Gln Leu 
            500                 505                 510         


Ser Gly Glu Thr Ser Ser Thr Lys Gln Asn Ser Gly Asp Glu Ser Ser 
        515                 520                 525             


Ser Gly Ile Lys Gly Ser Glu Lys Phe Asp Glu Asp Met Ser Gly Met 
    530                 535                 540                 


Pro Glu Pro Pro Glu Gly Met Asp Gly Lys Met Pro Pro Gly Met Gly 
545                 550                 555                 560 


Asn Met Asp Lys Gly Asp Met Asn Gly Lys Asn Gly Asn Met Asn Met 
                565                 570                 575     


Asp Arg Asn Gln Asp Asn Pro Arg Glu Ala Gly Gly Phe Gly Asn Arg 
            580                 585                 590         


Gly Gly Gly Ser Val Ser Lys Thr Thr Thr Tyr Phe Lys Leu Ile Leu 
        595                 600                 605             


Gly Gly Ala Ser Met Ile Ile Met Ser Ile Met Leu Val Gly Val Ser 
    610                 615                 620                 


Arg Val Lys Arg Arg Arg Phe Ile Lys Ser Lys 
625                 630                 635 


<210>  39
<211>  1905
<212>  DNA
<213>  Clostridium difficile

<400>  39
atgaaagata aaaaatttac ccttcttatc tcgattatga ttatattttt atgtgctgta       60

gttggagttt atagtacatc tagcaacaaa agtgttgatt tatatagtga tgtatatatt      120

gaaaaatatt ttaacagaga caaggttatg gaagttaata tagagataga tgaaagtgac      180

ttgaaggata tgaatgaaaa tgctataaaa gaagaattta aggttgcaaa agtaactgta      240

gatggagata catatggaaa cgtaggtata agaactaaag gaaattcaag tcttatatct      300

gtagcaaata gtgatagtga tagatacagc tataagatta attttgataa gtataatact      360

agtcaaagta tggaagggct tactcaatta aatcttaata actgttactc tgacccatct      420

tatatgagag agtttttaac atatagtatt tgcgaggaaa tgggattagc gactccagaa      480

tttgcatatg ctaaagtctc tataaatggc gaatatcatg gtttgtattt ggcagtagaa      540

ggattaaaag agtcttatct tgaaaataat tttggtaatg taactggaga cttatataag      600

tcagatgaag gaagctcgtt gcaatataaa ggagatgacc cagaaagtta ctcaaactta      660

atcgttgaaa gtgataaaaa gacagctgat tggtctaaaa tcacaaaact attaaaatct      720

ttggatacag gtgaagatat tgaaaaatat cttgatgtag attctgtcct taaaaatata      780

gcaataaata cagctttatt aaaccttgat agctatcaag ggagttttgc ccataactat      840

tatttatatg agcaagatgg agtattttct atgttaccat gggattttaa tatgtcattt      900

ggtggattta gtggttttgg tggaggtagt caatctatag caattgatga acctacgaca      960

ggtaatttag aagacagacc tctcatatcc tcgttattaa aaaatgagac atacaaaaca     1020

aaataccata aatatctgga agagatagta acaaaatacc tagattcaga ctatttagag     1080

aatatgacaa caaaattgca tgacatgata gcatcatatg taaaagaaga cccaacagca     1140

ttttatactt atgaagaatt tgaaaaaaat ataacatctt caattgaaga ttctagtgat     1200

aataagggat ttggtaataa agggtttgac aacaataact ctaataacag tgattctaat     1260

aataattcta atagtgaaaa taagcgctct ggaaatcaaa gtgatgaaaa agaagttaat     1320

gctgaattaa catcaagcgt agtcaaagct aatacagata atgaaactaa aaataaaact     1380

acaaatgata gtgaaagtaa gaataataca gataaagata aaagtggaaa tgataataat     1440

caaaagctag aaggtcctat gggtaaagga ggtaagtcaa taccaggggt tttggaagtt     1500

gcagaagata tgagtaaaac tataaaatct caattaagtg gagaaacttc ttcgacaaag     1560

caaaactctg gtgatgaaag ttcaagtgga attaaaggta gtgaaaagtt tgatgaggat     1620

atgagtggta tgccagaacc acctgaggga atggatggta aaatgccacc aggaatgggt     1680

aatatggata agggagatat gaatggtaaa aatggcaata tgaatatgga tagaaatcaa     1740

gataatccaa gagaagctgg aggttttggc aatagaggag gaggctctgt gagtaaaaca     1800

acaacatact tcaaattaat tttaggtgga gcttcaatga taataatgtc gattatgtta     1860

gttggtgtat caagggtaaa gagaagaaga tttataaagt caaaa                     1905


<210>  40
<211>  276
<212>  DNA
<213>  Clostridium difficile

<400>  40
atgaaaagtg ttgatttata tagtgatgta tatattgaaa aatattttaa cagagacaag       60

gttatggaag ttaatataga gatagatgaa agtgacttga aggatatgaa tgaaaatgct      120

ataaaagaag aatttaaggt tgcaaaagta actgtagatg gagatacata tggaaacgta      180

ggtataagaa ctaaaggaaa ttcaagtctt atatctgtag caaatagtga tagtgataga      240

tacagctata agattaattt tgataagtat aatact                                276


<210>  41
<211>  303
<212>  DNA
<213>  Clostridium difficile

<400>  41
atggtaactg gagacttata taagtcagat gaaggaagct cgttgcaata taaaggagat       60

gacccagaaa gttactcaaa cttaatcgtt gaaagtgata aaaagacagc tgattggtct      120

aaaatcacaa aactattaaa atctttggat acaggtgaag atattgaaaa atatcttgat      180

gtagattctg tccttaaaaa tatagcaata aatacagctt tattaaacct tgatagctat      240

caagggagtt ttgcccataa ctattattta tatgagcaag atggagtatt ttctatgtta      300

cca                                                                    303


<210>  42
<211>  303
<212>  DNA
<213>  Clostridium difficile

<400>  42
atgagtaaaa ctataaaatc tcaattaagt ggagaaactt cttcgacaaa gcaaaactct       60

ggtgatgaaa gttcaagtgg aattaaaggt agtgaaaagt ttgatgagga tatgagtggt      120

atgccagaac cacctgaggg aatggatggt aaaatgccac caggaatggg taatatggat      180

aagggagata tgaatggtaa aaatggcaat atgaatatgg atagaaatca agataatcca      240

agagaagctg gaggttttgg caatagagga ggaggctctg tgagtaaaac aacaacatac      300

ttc                                                                    303


<210>  43
<211>  2031
<212>  DNA
<213>  Clostridium difficile

<400>  43
atggtaagta aggagattaa tatgagaaga aatacaaaat tattaacaac agggattctt       60

tcaatggcaa tcgtcgcacc tacaatggca tttgctactg aatctaatgc tatggaaaat      120

aacgctgatt taaatataaa cttagagaaa aaaagtatcg ttttaggtag caaatcaaaa      180

gttagtgtca aatttaaaga aaaaccagat gcagatagca ttacattaaa gtataaatgc      240

tatgacatgc cattgaatac aactctaaat tacaatcaat caactggggc atatgaagga      300

actatcaatt ataaccaaga cccagaatat ctaaatgttt gggaactaca agggataaca      360

ataaacagca aaaataatca taaaacttta aacagacaag acctagaaaa gctgggatta      420

aatttaaaag actataatgt aacacaggaa tgtataattg aagatataac ttctagaaaa      480

gatgtaaata aatatttgag aaaaacttct tcacctatta cagaacttac aggaagtgat      540

agatatgaaa cagcagttaa aataagtaaa gagggctgga aaaatggttc agataaggta      600

gttataataa atggggatgt aagtatagat ggcattatat caactccact ggcaaccaca      660

tataatgcac caatactttt ggttgaaaaa aacaatgtac ctaatagtgt aaaatcagaa      720

ttaaagcgcc taaaccctaa agatataatt ataattggag atgagaatgc tatttctaaa      780

actactgcta atcaaattaa atcaactgta aatgctagtc aaacacgttt aaatggttct      840

aatagatatg agacatcttt attgatagca aaggaaatag ataaaaatca tgatgtggaa      900

aaagtataca taacaaatgc taatggcgga gaagtggatg cacttactat agcagcaaaa      960

gcaggtcaag acaagcaacc aattatatta actgataaag atagtattac agacaataca     1020

tataaatggt taaagagtga ggatttacaa aatgcttatt ttataggtgg tcctcaaatg     1080

atatcaacaa atgttataaa taaggtaaat ggaataacta aagatagtgt tactaataat     1140

agagtatacg gagcagatag acacgaaaca aatgcaaacg taataaaaaa attctataca     1200

gatgatgagt tagaggctgt tttagtagct aaatcagatg tacttgttga tgctttagca     1260

gcaggtccat tggctgcgaa cttaaaatct ccaatactta taacaccaaa gacgtatgta     1320

tctgcatacc ataaagataa tttagaagct aaatcagcta ataaggtata caaaatagga     1380

ggaggattga cttctaaggt aatgagctct atagcatcat cattatctaa acacaatacg     1440

actccaacag aaccaggaaa tagtgggggc aagacagtta tgattgaccc agggcatggt     1500

ggttcagcac ctggaaattc atctggagga atgattgaaa aagattacaa tttaaatact     1560

tcacttgcaa caactgaata tttacgttca aagggattca atgtaataat gacaagagac     1620

acagataaga ctttatctct tggaaataga actgctctat ctaattcatt gaaaccagat     1680

ttatttacaa gtatacatta taatggctca actaataaac aaggtcatgg tgtagaagta     1740

ttttataagc ttaaagataa aaatggaggg actactaaaa ctgtagctac caatatatta     1800

aatagaattt tagagaaatt taaacttaca aatagaggta taaaaacaag agtacttcct     1860

agtgattcta caaaagatta tttatacgtt ttaagaagta atgatatgcc agctgtactt     1920

gtagaatgtg catttttgga taatgaaaat gatatgagtt taataaactc atctgcaaaa     1980

gtaaaagaaa tgggtacaca aataggtaaa ggaatagaag attcattaaa a              2031


<210>  44
<211>  303
<212>  DNA
<213>  Clostridium difficile

<400>  44
atggataaaa atcatgatgt ggaaaaagta tacataacaa atgctaatgg cggagaagtg       60

gatgcactta ctatagcagc aaaagcaggt caagacaagc aaccaattat attaactgat      120

aaagatagta ttacagacaa tacatataaa tggttaaaga gtgaggattt acaaaatgct      180

tattttatag gtggtcctca aatgatatca acaaatgtta taaataaggt aaatggaata      240

actaaagata gtgttactaa taatagagta tacggagcag atagacacga aacaaatgca      300

aac                                                                    303


<210>  45
<211>  635
<212>  PRT
<213>  Clostridium difficile

<400>  45

Met Lys Asp Lys Lys Phe Thr Leu Leu Ile Ser Ile Met Ile Ile Phe 
1               5                   10                  15      


Leu Cys Ala Val Val Gly Val Tyr Ser Thr Ser Ser Asn Lys Ser Val 
            20                  25                  30          


Asp Leu Tyr Ser Asp Val Tyr Ile Glu Lys Tyr Phe Asn Arg Asp Lys 
        35                  40                  45              


Val Met Glu Val Asn Ile Glu Ile Asp Glu Ser Asp Leu Lys Asp Met 
    50                  55                  60                  


Asn Glu Asn Ala Ile Lys Glu Glu Phe Lys Val Ala Lys Val Thr Val 
65                  70                  75                  80  


Asp Gly Asp Thr Tyr Gly Asn Val Gly Ile Arg Thr Lys Gly Asn Ser 
                85                  90                  95      


Ser Leu Ile Ser Val Ala Asn Ser Asp Ser Asp Arg Tyr Ser Tyr Lys 
            100                 105                 110         


Ile Asn Phe Asp Lys Tyr Asn Thr Ser Gln Ser Met Glu Gly Leu Thr 
        115                 120                 125             


Gln Leu Asn Leu Asn Asn Cys Tyr Ser Asp Pro Ser Tyr Met Arg Glu 
    130                 135                 140                 


Phe Leu Thr Tyr Ser Ile Cys Glu Glu Met Gly Leu Ala Thr Pro Glu 
145                 150                 155                 160 


Phe Ala Tyr Ala Lys Val Ser Ile Asn Gly Glu Tyr His Gly Leu Tyr 
                165                 170                 175     


Leu Ala Val Glu Gly Leu Lys Glu Ser Tyr Leu Glu Asn Asn Phe Gly 
            180                 185                 190         


Asn Val Thr Gly Asp Leu Tyr Lys Ser Asp Glu Gly Ser Ser Leu Gln 
        195                 200                 205             


Tyr Lys Gly Asp Asp Pro Glu Ser Tyr Ser Asn Leu Ile Val Glu Ser 
    210                 215                 220                 


Asp Lys Lys Thr Ala Asp Trp Ser Lys Ile Thr Lys Leu Leu Lys Ser 
225                 230                 235                 240 


Leu Asp Thr Gly Glu Asp Ile Glu Lys Tyr Leu Asp Val Asp Ser Val 
                245                 250                 255     


Leu Lys Asn Ile Ala Ile Asn Thr Ala Leu Leu Asn Leu Asp Ser Tyr 
            260                 265                 270         


Gln Gly Ser Phe Ala His Asn Tyr Tyr Leu Tyr Glu Gln Asp Gly Val 
        275                 280                 285             


Phe Ser Met Leu Pro Trp Asp Phe Asn Met Ser Phe Gly Gly Phe Ser 
    290                 295                 300                 


Gly Phe Gly Gly Gly Ser Gln Ser Ile Ala Ile Asp Glu Pro Thr Thr 
305                 310                 315                 320 


Gly Asn Leu Glu Asp Arg Pro Leu Ile Ser Ser Leu Leu Lys Asn Glu 
                325                 330                 335     


Thr Tyr Lys Thr Lys Tyr His Lys Tyr Leu Glu Glu Ile Val Thr Lys 
            340                 345                 350         


Tyr Leu Asp Ser Asp Tyr Leu Glu Asn Met Thr Thr Lys Leu His Asp 
        355                 360                 365             


Met Ile Ala Ser Tyr Val Lys Glu Asp Pro Thr Ala Phe Tyr Thr Tyr 
    370                 375                 380                 


Glu Glu Phe Glu Lys Asn Ile Thr Ser Ser Ile Glu Asp Ser Ser Asp 
385                 390                 395                 400 


Asn Lys Gly Phe Gly Asn Lys Gly Phe Asp Asn Asn Asn Ser Asn Asn 
                405                 410                 415     


Ser Asp Ser Asn Asn Asn Ser Asn Ser Glu Asn Lys Arg Ser Gly Asn 
            420                 425                 430         


Gln Ser Asp Glu Lys Glu Val Asn Ala Glu Leu Thr Ser Ser Val Val 
        435                 440                 445             


Lys Ala Asn Thr Asp Asn Glu Thr Lys Asn Lys Thr Thr Asn Asp Ser 
    450                 455                 460                 


Glu Ser Lys Asn Asn Thr Asp Lys Asp Lys Ser Gly Asn Asp Asn Asn 
465                 470                 475                 480 


Gln Lys Leu Glu Gly Pro Met Gly Lys Gly Gly Lys Ser Ile Pro Gly 
                485                 490                 495     


Val Leu Glu Val Ala Glu Asp Met Ser Lys Thr Ile Lys Ser Gln Leu 
            500                 505                 510         


Ser Gly Glu Thr Ser Ser Thr Lys Gln Asn Ser Gly Asp Glu Ser Ser 
        515                 520                 525             


Ser Gly Ile Lys Gly Ser Glu Lys Phe Asp Glu Asp Met Ser Gly Met 
    530                 535                 540                 


Pro Glu Pro Pro Glu Gly Met Asp Gly Lys Met Pro Pro Gly Met Gly 
545                 550                 555                 560 


Asn Met Asp Lys Gly Asp Met Asn Gly Lys Asn Gly Asn Met Asn Met 
                565                 570                 575     


Asp Arg Asn Gln Asp Asn Pro Arg Glu Ala Gly Gly Phe Gly Asn Arg 
            580                 585                 590         


Gly Gly Gly Ser Val Ser Lys Thr Thr Thr Tyr Phe Lys Leu Ile Leu 
        595                 600                 605             


Gly Gly Ala Ser Met Ile Ile Met Ser Ile Met Leu Val Gly Val Ser 
    610                 615                 620                 


Arg Val Lys Arg Arg Arg Phe Ile Lys Ser Lys 
625                 630                 635 


<210>  46
<211>  92
<212>  PRT
<213>  Clostridium difficile

<400>  46

Met Lys Ser Val Asp Leu Tyr Ser Asp Val Tyr Ile Glu Lys Tyr Phe 
1               5                   10                  15      


Asn Arg Asp Lys Val Met Glu Val Asn Ile Glu Ile Asp Glu Ser Asp 
            20                  25                  30          


Leu Lys Asp Met Asn Glu Asn Ala Ile Lys Glu Glu Phe Lys Val Ala 
        35                  40                  45              


Lys Val Thr Val Asp Gly Asp Thr Tyr Gly Asn Val Gly Ile Arg Thr 
    50                  55                  60                  


Lys Gly Asn Ser Ser Leu Ile Ser Val Ala Asn Ser Asp Ser Asp Arg 
65                  70                  75                  80  


Tyr Ser Tyr Lys Ile Asn Phe Asp Lys Tyr Asn Thr 
                85                  90          


<210>  47
<211>  101
<212>  PRT
<213>  Clostridium difficile

<400>  47

Met Val Thr Gly Asp Leu Tyr Lys Ser Asp Glu Gly Ser Ser Leu Gln 
1               5                   10                  15      


Tyr Lys Gly Asp Asp Pro Glu Ser Tyr Ser Asn Leu Ile Val Glu Ser 
            20                  25                  30          


Asp Lys Lys Thr Ala Asp Trp Ser Lys Ile Thr Lys Leu Leu Lys Ser 
        35                  40                  45              


Leu Asp Thr Gly Glu Asp Ile Glu Lys Tyr Leu Asp Val Asp Ser Val 
    50                  55                  60                  


Leu Lys Asn Ile Ala Ile Asn Thr Ala Leu Leu Asn Leu Asp Ser Tyr 
65                  70                  75                  80  


Gln Gly Ser Phe Ala His Asn Tyr Tyr Leu Tyr Glu Gln Asp Gly Val 
                85                  90                  95      


Phe Ser Met Leu Pro 
            100     


<210>  48
<211>  101
<212>  PRT
<213>  Clostridium difficile

<400>  48

Met Ser Lys Thr Ile Lys Ser Gln Leu Ser Gly Glu Thr Ser Ser Thr 
1               5                   10                  15      


Lys Gln Asn Ser Gly Asp Glu Ser Ser Ser Gly Ile Lys Gly Ser Glu 
            20                  25                  30          


Lys Phe Asp Glu Asp Met Ser Gly Met Pro Glu Pro Pro Glu Gly Met 
        35                  40                  45              


Asp Gly Lys Met Pro Pro Gly Met Gly Asn Met Asp Lys Gly Asp Met 
    50                  55                  60                  


Asn Gly Lys Asn Gly Asn Met Asn Met Asp Arg Asn Gln Asp Asn Pro 
65                  70                  75                  80  


Arg Glu Ala Gly Gly Phe Gly Asn Arg Gly Gly Gly Ser Val Ser Lys 
                85                  90                  95      


Thr Thr Thr Tyr Phe 
            100     


<210>  49
<211>  677
<212>  PRT
<213>  Clostridium difficile

<400>  49

Met Val Ser Lys Glu Ile Asn Met Arg Arg Asn Thr Lys Leu Leu Thr 
1               5                   10                  15      


Thr Gly Ile Leu Ser Met Ala Ile Val Ala Pro Thr Met Ala Phe Ala 
            20                  25                  30          


Thr Glu Ser Asn Ala Met Glu Asn Asn Ala Asp Leu Asn Ile Asn Leu 
        35                  40                  45              


Glu Lys Lys Ser Ile Val Leu Gly Ser Lys Ser Lys Val Ser Val Lys 
    50                  55                  60                  


Phe Lys Glu Lys Pro Asp Ala Asp Ser Ile Thr Leu Lys Tyr Lys Cys 
65                  70                  75                  80  


Tyr Asp Met Pro Leu Asn Thr Thr Leu Asn Tyr Asn Gln Ser Thr Gly 
                85                  90                  95      


Ala Tyr Glu Gly Thr Ile Asn Tyr Asn Gln Asp Pro Glu Tyr Leu Asn 
            100                 105                 110         


Val Trp Glu Leu Gln Gly Ile Thr Ile Asn Ser Lys Asn Asn His Lys 
        115                 120                 125             


Thr Leu Asn Arg Gln Asp Leu Glu Lys Leu Gly Leu Asn Leu Lys Asp 
    130                 135                 140                 


Tyr Asn Val Thr Gln Glu Cys Ile Ile Glu Asp Ile Thr Ser Arg Lys 
145                 150                 155                 160 


Asp Val Asn Lys Tyr Leu Arg Lys Thr Ser Ser Pro Ile Thr Glu Leu 
                165                 170                 175     


Thr Gly Ser Asp Arg Tyr Glu Thr Ala Val Lys Ile Ser Lys Glu Gly 
            180                 185                 190         


Trp Lys Asn Gly Ser Asp Lys Val Val Ile Ile Asn Gly Asp Val Ser 
        195                 200                 205             


Ile Asp Gly Ile Ile Ser Thr Pro Leu Ala Thr Thr Tyr Asn Ala Pro 
    210                 215                 220                 


Ile Leu Leu Val Glu Lys Asn Asn Val Pro Asn Ser Val Lys Ser Glu 
225                 230                 235                 240 


Leu Lys Arg Leu Asn Pro Lys Asp Ile Ile Ile Ile Gly Asp Glu Asn 
                245                 250                 255     


Ala Ile Ser Lys Thr Thr Ala Asn Gln Ile Lys Ser Thr Val Asn Ala 
            260                 265                 270         


Ser Gln Thr Arg Leu Asn Gly Ser Asn Arg Tyr Glu Thr Ser Leu Leu 
        275                 280                 285             


Ile Ala Lys Glu Ile Asp Lys Asn His Asp Val Glu Lys Val Tyr Ile 
    290                 295                 300                 


Thr Asn Ala Asn Gly Gly Glu Val Asp Ala Leu Thr Ile Ala Ala Lys 
305                 310                 315                 320 


Ala Gly Gln Asp Lys Gln Pro Ile Ile Leu Thr Asp Lys Asp Ser Ile 
                325                 330                 335     


Thr Asp Asn Thr Tyr Lys Trp Leu Lys Ser Glu Asp Leu Gln Asn Ala 
            340                 345                 350         


Tyr Phe Ile Gly Gly Pro Gln Met Ile Ser Thr Asn Val Ile Asn Lys 
        355                 360                 365             


Val Asn Gly Ile Thr Lys Asp Ser Val Thr Asn Asn Arg Val Tyr Gly 
    370                 375                 380                 


Ala Asp Arg His Glu Thr Asn Ala Asn Val Ile Lys Lys Phe Tyr Thr 
385                 390                 395                 400 


Asp Asp Glu Leu Glu Ala Val Leu Val Ala Lys Ser Asp Val Leu Val 
                405                 410                 415     


Asp Ala Leu Ala Ala Gly Pro Leu Ala Ala Asn Leu Lys Ser Pro Ile 
            420                 425                 430         


Leu Ile Thr Pro Lys Thr Tyr Val Ser Ala Tyr His Lys Asp Asn Leu 
        435                 440                 445             


Glu Ala Lys Ser Ala Asn Lys Val Tyr Lys Ile Gly Gly Gly Leu Thr 
    450                 455                 460                 


Ser Lys Val Met Ser Ser Ile Ala Ser Ser Leu Ser Lys His Asn Thr 
465                 470                 475                 480 


Thr Pro Thr Glu Pro Gly Asn Ser Gly Gly Lys Thr Val Met Ile Asp 
                485                 490                 495     


Pro Gly His Gly Gly Ser Ala Pro Gly Asn Ser Ser Gly Gly Met Ile 
            500                 505                 510         


Glu Lys Asp Tyr Asn Leu Asn Thr Ser Leu Ala Thr Thr Glu Tyr Leu 
        515                 520                 525             


Arg Ser Lys Gly Phe Asn Val Ile Met Thr Arg Asp Thr Asp Lys Thr 
    530                 535                 540                 


Leu Ser Leu Gly Asn Arg Thr Ala Leu Ser Asn Ser Leu Lys Pro Asp 
545                 550                 555                 560 


Leu Phe Thr Ser Ile His Tyr Asn Gly Ser Thr Asn Lys Gln Gly His 
                565                 570                 575     


Gly Val Glu Val Phe Tyr Lys Leu Lys Asp Lys Asn Gly Gly Thr Thr 
            580                 585                 590         


Lys Thr Val Ala Thr Asn Ile Leu Asn Arg Ile Leu Glu Lys Phe Lys 
        595                 600                 605             


Leu Thr Asn Arg Gly Ile Lys Thr Arg Val Leu Pro Ser Asp Ser Thr 
    610                 615                 620                 


Lys Asp Tyr Leu Tyr Val Leu Arg Ser Asn Asp Met Pro Ala Val Leu 
625                 630                 635                 640 


Val Glu Cys Ala Phe Leu Asp Asn Glu Asn Asp Met Ser Leu Ile Asn 
                645                 650                 655     


Ser Ser Ala Lys Val Lys Glu Met Gly Thr Gln Ile Gly Lys Gly Ile 
            660                 665                 670         


Glu Asp Ser Leu Lys 
        675         


<210>  50
<211>  101
<212>  PRT
<213>  Clostridium difficile

<400>  50

Met Asp Lys Asn His Asp Val Glu Lys Val Tyr Ile Thr Asn Ala Asn 
1               5                   10                  15      


Gly Gly Glu Val Asp Ala Leu Thr Ile Ala Ala Lys Ala Gly Gln Asp 
            20                  25                  30          


Lys Gln Pro Ile Ile Leu Thr Asp Lys Asp Ser Ile Thr Asp Asn Thr 
        35                  40                  45              


Tyr Lys Trp Leu Lys Ser Glu Asp Leu Gln Asn Ala Tyr Phe Ile Gly 
    50                  55                  60                  


Gly Pro Gln Met Ile Ser Thr Asn Val Ile Asn Lys Val Asn Gly Ile 
65                  70                  75                  80  


Thr Lys Asp Ser Val Thr Asn Asn Arg Val Tyr Gly Ala Asp Arg His 
                85                  90                  95      


Glu Thr Asn Ala Asn 
            100     


