
                                SEQUENCE LISTING

<110> Intradigm Corporation
	Xie, Frank Y.
	Yang, Xiaodong
	Liu, Ying

<120> COMPOSITIONS COMPRISING K-RAS siRNA AND 
	METHODS OF USE
  

<130> 480251.407PC

<140> PCT                 
<141> 2008-09-18  

<160> 488

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 1
uaaacuugug guaguuggag cuguu                                       25

<210> 2
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 2
aacagcucca acuaccacaa guuua                                       25

<210> 3
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 3
aaacuugugg uaguuggagc uguug                                       25

<210> 4
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 4
caacagcucc aacuaccaca aguuu                                       25

<210> 5
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 5
aacuuguggu aguuggagcu guugg                                       25

<210> 6
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 6
ccaacagcuc caacuaccac aaguu                                       25

<210> 7
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 7
acuuguggua guuggagcug uuggc                                       25

<210> 8
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 8
gccaacagcu ccaacuacca caagu                                       25

<210> 9
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 9
cuugugguag uuggagcugu uggcg                                       25

<210> 10
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 10
cgccaacagc uccaacuacc acaag                                       25

<210> 11
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 11
uugugguagu uggagcuguu ggcgu                                       25

<210> 12
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 12
acgccaacag cuccaacuac cacaa                                       25

<210> 13
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 13
ugugguaguu ggagcuguug gcgua                                       25

<210> 14
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 14
uacgccaaca gcuccaacua ccaca                                       25

<210> 15
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 15
gugguaguug gagcuguugg cguag                                       25

<210> 16
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 16
cuacgccaac agcuccaacu accac                                       25

<210> 17
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 17
ugguaguugg agcuguuggc guagg                                       25

<210> 18
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 18
ccuacgccaa cagcuccaac uacca                                       25

<210> 19
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 19
gguaguugga gcuguuggcg uaggc                                       25

<210> 20
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 20
gccuacgcca acagcuccaa cuacc                                       25

<210> 21
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 21
guaguuggag cuguuggcgu aggca                                       25

<210> 22
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 22
ugccuacgcc aacagcucca acuac                                       25

<210> 23
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 23
uaguuggagc uguuggcgua ggcaa                                       25

<210> 24
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 24
uugccuacgc caacagcucc aacua                                       25

<210> 25
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 25
aguuggagcu guuggcguag gcaag                                       25

<210> 26
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 26
cuugccuacg ccaacagcuc caacu                                       25

<210> 27
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 27
guuggagcug uuggcguagg caaga                                       25

<210> 28
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 28
ucuugccuac gccaacagcu ccaac                                       25

<210> 29
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 29
uuggagcugu uggcguaggc aagag                                       25

<210> 30
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 30
cucuugccua cgccaacagc uccaa                                       25

<210> 31
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 31
uggagcuguu ggcguaggca agagu                                       25

<210> 32
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 32
acucuugccu acgccaacag cucca                                       25

<210> 33
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 33
ggagcuguug gcguaggcaa gagug                                       25

<210> 34
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 34
cacucuugcc uacgccaaca gcucc                                       25

<210> 35
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 35
gagcuguugg cguaggcaag agugc                                       25

<210> 36
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 36
gcacucuugc cuacgccaac agcuc                                       25

<210> 37
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 37
agcuguuggc guaggcaaga gugcc                                       25

<210> 38
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 38
ggcacucuug ccuacgccaa cagcu                                       25

<210> 39
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 39
gcuguuggcg uaggcaagag ugccu                                       25

<210> 40
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 40
aggcacucuu gccuacgcca acagc                                       25

<210> 41
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 41
cuguuggcgu aggcaagagu gccuu                                       25

<210> 42
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 42
aaggcacucu ugccuacgcc aacag                                       25

<210> 43
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 43
uguuggcgua ggcaagagug ccuug                                       25

<210> 44
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 44
caaggcacuc uugccuacgc caaca                                       25

<210> 45
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 45
guuggcguag gcaagagugc cuuga                                       25

<210> 46
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Val

<400> 46
ucaaggcacu cuugccuacg ccaac                                       25

<210> 47
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 47
uaaacuugug guaguuggag cugau                                       25

<210> 48
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 48
aucagcucca acuaccacaa guuua                                       25

<210> 49
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 49
aaacuugugg uaguuggagc ugaug                                       25

<210> 50
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 50
caucagcucc aacuaccaca aguuu                                       25

<210> 51
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 51
aacuuguggu aguuggagcu gaugg                                       25

<210> 52
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 52
ccaucagcuc caacuaccac aaguu                                       25

<210> 53
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 53
acuuguggua guuggagcug auggc                                       25

<210> 54
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 54
gccaucagcu ccaacuacca caagu                                       25

<210> 55
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 55
cuugugguag uuggagcuga uggcg                                       25

<210> 56
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 56
cgccaucagc uccaacuacc acaag                                       25

<210> 57
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 57
uugugguagu uggagcugau ggcgu                                       25

<210> 58
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 58
acgccaucag cuccaacuac cacaa                                       25

<210> 59
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 59
ugugguaguu ggagcugaug gcgua                                       25

<210> 60
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 60
uacgccauca gcuccaacua ccaca                                       25

<210> 61
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 61
gugguaguug gagcugaugg cguag                                       25

<210> 62
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 62
cuacgccauc agcuccaacu accac                                       25

<210> 63
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 63
ugguaguugg agcugauggc guagg                                       25

<210> 64
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 64
ccuacgccau cagcuccaac uacca                                       25

<210> 65
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 65
gguaguugga gcugauggcg uaggc                                       25

<210> 66
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 66
gccuacgcca ucagcuccaa cuacc                                       25

<210> 67
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 67
guaguuggag cugauggcgu aggca                                       25

<210> 68
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 68
ugccuacgcc aucagcucca acuac                                       25

<210> 69
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 69
uaguuggagc ugauggcgua ggcaa                                       25

<210> 70
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 70
uugccuacgc caucagcucc aacua                                       25

<210> 71
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 71
aguuggagcu gauggcguag gcaag                                       25

<210> 72
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 72
cuugccuacg ccaucagcuc caacu                                       25

<210> 73
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 73
guuggagcug auggcguagg caaga                                       25

<210> 74
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 74
ucuugccuac gccaucagcu ccaac                                       25

<210> 75
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 75
uuggagcuga uggcguaggc aagag                                       25

<210> 76
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 76
cucuugccua cgccaucagc uccaa                                       25

<210> 77
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 77
uggagcugau ggcguaggca agagu                                       25

<210> 78
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 78
acucuugccu acgccaucag cucca                                       25

<210> 79
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 79
ggagcugaug gcguaggcaa gagug                                       25

<210> 80
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 80
cacucuugcc uacgccauca gcucc                                       25

<210> 81
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 81
gagcugaugg cguaggcaag agugc                                       25

<210> 82
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 82
gcacucuugc cuacgccauc agcuc                                       25

<210> 83
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 83
agcugauggc guaggcaaga gugcc                                       25

<210> 84
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 84
ggcacucuug ccuacgccau cagcu                                       25

<210> 85
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 85
gcugauggcg uaggcaagag ugccu                                       25

<210> 86
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 86
aggcacucuu gccuacgcca ucagc                                       25

<210> 87
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 87
cugauggcgu aggcaagagu gccuu                                       25

<210> 88
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 88
aaggcacucu ugccuacgcc aucag                                       25

<210> 89
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 89
ugauggcgua ggcaagagug ccuug                                       25

<210> 90
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 90
caaggcacuc uugccuacgc cauca                                       25

<210> 91
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 91
gauggcguag gcaagagugc cuuga                                       25

<210> 92
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 92
ucaaggcacu cuugccuacg ccauc                                       25

<210> 93
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 93
uaaacuugug guaguuggag cuugu                                       25

<210> 94
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 94
acaagcucca acuaccacaa guuua                                       25

<210> 95
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 95
aaacuugugg uaguuggagc uugug                                       25

<210> 96
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 96
cacaagcucc aacuaccaca aguuu                                       25

<210> 97
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 97
aacuuguggu aguuggagcu ugugg                                       25

<210> 98
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 98
ccacaagcuc caacuaccac aaguu                                       25

<210> 99
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 99
acuuguggua guuggagcuu guggc                                       25

<210> 100
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 100
gccacaagcu ccaacuacca caagu                                       25

<210> 101
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 101
cuugugguag uuggagcuug uggcg                                       25

<210> 102
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 102
cgccacaagc uccaacuacc acaag                                       25

<210> 103
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 103
uugugguagu uggagcuugu ggcgu                                       25

<210> 104
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 104
acgccacaag cuccaacuac cacaa                                       25

<210> 105
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 105
ugugguaguu ggagcuugug gcgua                                       25

<210> 106
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 106
uacgccacaa gcuccaacua ccaca                                       25

<210> 107
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 107
gugguaguug gagcuugugg cguag                                       25

<210> 108
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 108
cuacgccaca agcuccaacu accac                                       25

<210> 109
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 109
ugguaguugg agcuuguggc guagg                                       25

<210> 110
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 110
ccuacgccac aagcuccaac uacca                                       25

<210> 111
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 111
gguaguugga gcuuguggcg uaggc                                       25

<210> 112
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 112
gccuacgcca caagcuccaa cuacc                                       25

<210> 113
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 113
guaguuggag cuuguggcgu aggca                                       25

<210> 114
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 114
ugccuacgcc acaagcucca acuac                                       25

<210> 115
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 115
uaguuggagc uuguggcgua ggcaa                                       25

<210> 116
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 116
uugccuacgc cacaagcucc aacua                                       25

<210> 117
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 117
aguuggagcu uguggcguag gcaag                                       25

<210> 118
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 118
cuugccuacg ccacaagcuc caacu                                       25

<210> 119
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 119
guuggagcuu guggcguagg caaga                                       25

<210> 120
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 120
ucuugccuac gccacaagcu ccaac                                       25

<210> 121
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 121
uuggagcuug uggcguaggc aagag                                       25

<210> 122
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 122
cucuugccua cgccacaagc uccaa                                       25

<210> 123
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 123
uggagcuugu ggcguaggca agagu                                       25

<210> 124
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 124
acucuugccu acgccacaag cucca                                       25

<210> 125
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 125
ggagcuugug gcguaggcaa gagug                                       25

<210> 126
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 126
cacucuugcc uacgccacaa gcucc                                       25

<210> 127
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 127
gagcuugugg cguaggcaag agugc                                       25

<210> 128
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 128
gcacucuugc cuacgccaca agcuc                                       25

<210> 129
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 129
agcuuguggc guaggcaaga gugcc                                       25

<210> 130
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 130
ggcacucuug ccuacgccac aagcu                                       25

<210> 131
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 131
gcuuguggcg uaggcaagag ugccu                                       25

<210> 132
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 132
aggcacucuu gccuacgcca caagc                                       25

<210> 133
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 133
cuuguggcgu aggcaagagu gccuu                                       25

<210> 134
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 134
aaggcacucu ugccuacgcc acaag                                       25

<210> 135
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 135
uuguggcgua ggcaagagug ccuug                                       25

<210> 136
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 136
caaggcacuc uugccuacgc cacaa                                       25

<210> 137
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 137
uguggcguag gcaagagugc cuuga                                       25

<210> 138
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Cys

<400> 138
ucaaggcacu cuugccuacg ccaca                                       25

<210> 139
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 139
uaaacuugug guaguuggag cuagu                                       25

<210> 140
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 140
acuagcucca acuaccacaa guuua                                       25

<210> 141
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 141
aaacuugugg uaguuggagc uagug                                       25

<210> 142
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 142
cacuagcucc aacuaccaca aguuu                                       25

<210> 143
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 143
aacuuguggu aguuggagcu agugg                                       25

<210> 144
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 144
ccacuagcuc caacuaccac aaguu                                       25

<210> 145
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 145
acuuguggua guuggagcua guggc                                       25

<210> 146
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 146
gccacuagcu ccaacuacca caagu                                       25

<210> 147
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 147
cuugugguag uuggagcuag uggcg                                       25

<210> 148
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 148
cgccacuagc uccaacuacc acaag                                       25

<210> 149
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 149
uugugguagu uggagcuagu ggcgu                                       25

<210> 150
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 150
acgccacuag cuccaacuac cacaa                                       25

<210> 151
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 151
ugugguaguu ggagcuagug gcgua                                       25

<210> 152
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 152
uacgccacua gcuccaacua ccaca                                       25

<210> 153
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 153
gugguaguug gagcuagugg cguag                                       25

<210> 154
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 154
cuacgccacu agcuccaacu accac                                       25

<210> 155
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 155
ugguaguugg agcuaguggc guagg                                       25

<210> 156
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 156
ccuacgccac uagcuccaac uacca                                       25

<210> 157
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 157
gguaguugga gcuaguggcg uaggc                                       25

<210> 158
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 158
gccuacgcca cuagcuccaa cuacc                                       25

<210> 159
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 159
guaguuggag cuaguggcgu aggca                                       25

<210> 160
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 160
ugccuacgcc acuagcucca acuac                                       25

<210> 161
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 161
uaguuggagc uaguggcgua ggcaa                                       25

<210> 162
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 162
uugccuacgc cacuagcucc aacua                                       25

<210> 163
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 163
aguuggagcu aguggcguag gcaag                                       25

<210> 164
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 164
cuugccuacg ccacuagcuc caacu                                       25

<210> 165
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 165
guuggagcua guggcguagg caaga                                       25

<210> 166
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 166
ucuugccuac gccacuagcu ccaac                                       25

<210> 167
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 167
uuggagcuag uggcguaggc aagag                                       25

<210> 168
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 168
cucuugccua cgccacuagc uccaa                                       25

<210> 169
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 169
uggagcuagu ggcguaggca agagu                                       25

<210> 170
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 170
acucuugccu acgccacuag cucca                                       25

<210> 171
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 171
ggagcuagug gcguaggcaa gagug                                       25

<210> 172
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 172
cacucuugcc uacgccacua gcucc                                       25

<210> 173
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 173
gagcuagugg cguaggcaag agugc                                       25

<210> 174
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 174
gcacucuugc cuacgccacu agcuc                                       25

<210> 175
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 175
agcuaguggc guaggcaaga gugcc                                       25

<210> 176
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 176
ggcacucuug ccuacgccac uagcu                                       25

<210> 177
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 177
gcuaguggcg uaggcaagag ugccu                                       25

<210> 178
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 178
aggcacucuu gccuacgcca cuagc                                       25

<210> 179
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 179
cuaguggcgu aggcaagagu gccuu                                       25

<210> 180
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 180
aaggcacucu ugccuacgcc acuag                                       25

<210> 181
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 181
uaguggcgua ggcaagagug ccuug                                       25

<210> 182
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 182
caaggcacuc uugccuacgc cacua                                       25

<210> 183
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 183
aguggcguag gcaagagugc cuuga                                       25

<210> 184
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ser

<400> 184
ucaaggcacu cuugccuacg ccacu                                       25

<210> 185
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 185
uaaacuugug guaguuggag cugcu                                       25

<210> 186
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 186
agcagcucca acuaccacaa guuua                                       25

<210> 187
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 187
aaacuugugg uaguuggagc ugcug                                       25

<210> 188
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 188
cagcagcucc aacuaccaca aguuu                                       25

<210> 189
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 189
aacuuguggu aguuggagcu gcugg                                       25

<210> 190
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 190
ccagcagcuc caacuaccac aaguu                                       25

<210> 191
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 191
acuuguggua guuggagcug cuggc                                       25

<210> 192
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 192
gccagcagcu ccaacuacca caagu                                       25

<210> 193
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 193
cuugugguag uuggagcugc uggcg                                       25

<210> 194
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 194
cgccagcagc uccaacuacc acaag                                       25

<210> 195
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 195
uugugguagu uggagcugcu ggcgu                                       25

<210> 196
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 196
acgccagcag cuccaacuac cacaa                                       25

<210> 197
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 197
ugugguaguu ggagcugcug gcgua                                       25

<210> 198
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 198
uacgccagca gcuccaacua ccaca                                       25

<210> 199
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 199
gugguaguug gagcugcugg cguag                                       25

<210> 200
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 200
cuacgccagc agcuccaacu accac                                       25

<210> 201
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 201
ugguaguugg agcugcuggc guagg                                       25

<210> 202
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 202
ccuacgccag cagcuccaac uacca                                       25

<210> 203
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 203
gguaguugga gcugcuggcg uaggc                                       25

<210> 204
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 204
gccuacgcca gcagcuccaa cuacc                                       25

<210> 205
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 205
guaguuggag cugcuggcgu aggca                                       25

<210> 206
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 206
ugccuacgcc agcagcucca acuac                                       25

<210> 207
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 207
uaguuggagc ugcuggcgua ggcaa                                       25

<210> 208
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 208
uugccuacgc cagcagcucc aacua                                       25

<210> 209
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 209
aguuggagcu gcuggcguag gcaag                                       25

<210> 210
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 210
cuugccuacg ccagcagcuc caacu                                       25

<210> 211
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 211
guuggagcug cuggcguagg caaga                                       25

<210> 212
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 212
ucuugccuac gccagcagcu ccaac                                       25

<210> 213
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 213
uuggagcugc uggcguaggc aagag                                       25

<210> 214
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 214
cucuugccua cgccagcagc uccaa                                       25

<210> 215
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 215
uggagcugcu ggcguaggca agagu                                       25

<210> 216
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 216
acucuugccu acgccagcag cucca                                       25

<210> 217
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 217
ggagcuguug gcguaggcaa gagug                                       25

<210> 218
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 218
cacucuugcc uacgccagca gcucc                                       25

<210> 219
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 219
gagcugcugg cguaggcaag agugc                                       25

<210> 220
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 220
gcacucuugc cuacgccagc agcuc                                       25

<210> 221
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 221
agcugcuggc guaggcaaga gugcc                                       25

<210> 222
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 222
ggcacucuug ccuacgccag cagcu                                       25

<210> 223
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 223
gcugcuggcg uaggcaagag ugccu                                       25

<210> 224
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 224
aggcacucuu gccuacgcca gcagc                                       25

<210> 225
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 225
cugcuggcgu aggcaagagu gccuu                                       25

<210> 226
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 226
aaggcacucu ugccuacgcc agcag                                       25

<210> 227
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 227
ugcuggcgua ggcaagagug ccuug                                       25

<210> 228
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 228
caaggcacuc uugccuacgc cagca                                       25

<210> 229
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 229
gcuggcguag gcaagagugc cuuga                                       25

<210> 230
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Ala

<400> 230
ucaaggcacu cuugccuacg ccagc                                       25

<210> 231
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 231
uaaacuugug guaguuggag cucgu                                       25

<210> 232
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 232
acgagcucca acuaccacaa guuua                                       25

<210> 233
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 233
aaacuugugg uaguuggagc ucgug                                       25

<210> 234
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 234
cacgagcucc aacuaccaca aguuu                                       25

<210> 235
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 235
aacuuguggu aguuggagcu cgugg                                       25

<210> 236
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 236
ccacgagcuc caacuaccac aaguu                                       25

<210> 237
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 237
acuuguggua guuggagcuc guggc                                       25

<210> 238
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 238
gccacgagcu ccaacuacca caagu                                       25

<210> 239
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 239
cuugugguag uuggagcucg uggcg                                       25

<210> 240
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 240
cgccacgagc uccaacuacc acaag                                       25

<210> 241
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 241
uugugguagu uggagcucgu ggcgu                                       25

<210> 242
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 242
acgccacgag cuccaacuac cacaa                                       25

<210> 243
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 243
ugugguaguu ggagcucgug gcgua                                       25

<210> 244
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 244
uacgccacga gcuccaacua ccaca                                       25

<210> 245
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 245
gugguaguug gagcucgugg cguag                                       25

<210> 246
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 246
cuacgccacg agcuccaacu accac                                       25

<210> 247
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 247
ugguaguugg agcucguggc guagg                                       25

<210> 248
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 248
ccuacgccac gagcuccaac uacca                                       25

<210> 249
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 249
gguaguugga gcucguggcg uaggc                                       25

<210> 250
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 250
gccuacgcca cgagcuccaa cuacc                                       25

<210> 251
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 251
guaguuggag cucguggcgu aggca                                       25

<210> 252
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 252
ugccuacgcc acgagcucca acuac                                       25

<210> 253
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 253
uaguuggagc ucguggcgua ggcaa                                       25

<210> 254
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 254
uugccuacgc cacgagcucc aacua                                       25

<210> 255
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 255
aguuggagcu cguggcguag gcaag                                       25

<210> 256
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 256
cuugccuacg ccacgagcuc caacu                                       25

<210> 257
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 257
guuggagcuc guggcguagg caaga                                       25

<210> 258
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 258
ucuugccuac gccacgagcu ccaac                                       25

<210> 259
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 259
uuggagcucg uggcguaggc aagag                                       25

<210> 260
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 260
cucuugccua cgccacgagc uccaa                                       25

<210> 261
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 261
uggagcucgu ggcguaggca agagu                                       25

<210> 262
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 262
acucuugccu acgccacgag cucca                                       25

<210> 263
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 263
ggagcucgug gcguaggcaa gagug                                       25

<210> 264
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 264
cacucuugcc uacgccaaca gcucc                                       25

<210> 265
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 265
gagcucgugg cguaggcaag agugc                                       25

<210> 266
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 266
gcacucuugc cuacgccacg agcuc                                       25

<210> 267
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 267
agcucguggc guaggcaaga gugcc                                       25

<210> 268
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 268
ggcacucuug ccuacgccac gagcu                                       25

<210> 269
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 269
gcucguggcg uaggcaagag ugccu                                       25

<210> 270
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 270
aggcacucuu gccuacgcca cgagc                                       25

<210> 271
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 271
cucguggcgu aggcaagagu gccuu                                       25

<210> 272
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 272
aaggcacucu ugccuacgcc acgag                                       25

<210> 273
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 273
ucguggcgua ggcaagagug ccuug                                       25

<210> 274
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 274
caaggcacuc uugccuacgc cacga                                       25

<210> 275
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 275
cguggcguag gcaagagugc cuuga                                       25

<210> 276
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Arg

<400> 276
ucaaggcacu cuugccuacg ccacg                                       25

<210> 277
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 277
acuuguggua guuggagcug gugac                                       25

<210> 278
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 278
gucaccagcu ccaacuacca caagu                                       25

<210> 279
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 279
cuugugguag uuggagcugg ugacg                                       25

<210> 280
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 280
cgucaccagc uccaacuacc acaag                                       25

<210> 281
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 281
uugugguagu uggagcuggu gacgu                                       25

<210> 282
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 282
acgucaacag cuccaacuac cacaa                                       25

<210> 283
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 283
ugugguaguu ggagcuggug acgua                                       25

<210> 284
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 284
uacgucaaca gcuccaacua ccaca                                       25

<210> 285
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 285
gugguaguug gagcugguga cguag                                       25

<210> 286
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 286
cuacgucaac agcuccaacu accac                                       25

<210> 287
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 287
ugguaguugg agcuggugac guagg                                       25

<210> 288
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 288
ccuacgucac cagcuccaac uacca                                       25

<210> 289
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 289
gguaguugga gcuggugacg uaggc                                       25

<210> 290
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 290
gccuacguca ccagcuccaa cuacc                                       25

<210> 291
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 291
guaguuggag cuggugacgu aggca                                       25

<210> 292
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 292
ugccuacguc accagcucca acuac                                       25

<210> 293
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 293
uaguuggagc uggugacgua ggcaa                                       25

<210> 294
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 294
uugccuacgu caccagcucc aacua                                       25

<210> 295
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 295
aguuggagcu ggugacguag gcaag                                       25

<210> 296
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 296
cuugccuacg ucaccagcuc caacu                                       25

<210> 297
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 297
guuggagcug gugacguagg caaga                                       25

<210> 298
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 298
ucuugccuac gucaccagcu ccaac                                       25

<210> 299
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 299
uuggagcugg ugacguaggc aagag                                       25

<210> 300
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 300
cucuugccua cgucaccagc uccaa                                       25

<210> 301
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 301
uggagcuggu gacguaggca agagu                                       25

<210> 302
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 302
acucuugccu acgucaccag cucca                                       25

<210> 303
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 303
ggagcuggug acguaggcaa gagug                                       25

<210> 304
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 304
cacucuugcc uacgucacca gcucc                                       25

<210> 305
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 305
gagcugguga cguaggcaag agugc                                       25

<210> 306
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 306
gcacucuugc cuacgucacc agcuc                                       25

<210> 307
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 307
agcuggugac guaggcaaga gugcc                                       25

<210> 308
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 308
ggcacucuug ccuacgucac cagcu                                       25

<210> 309
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 309
gcuggugacg uaggcaagag ugccu                                       25

<210> 310
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 310
aggcacucuu gccuacguca ccagc                                       25

<210> 311
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 311
cuggugacgu aggcaagagu gccuu                                       25

<210> 312
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 312
aaggcacucu ugccuacguc accag                                       25

<210> 313
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 313
uggugacgua ggcaagagug ccuug                                       25

<210> 314
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 314
caaggcacuc uugccuacgu cacca                                       25

<210> 315
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 315
ggugacguag gcaagagugc cuuga                                       25

<210> 316
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 316
ucaaggcacu cuugccuacg ucacc                                       25

<210> 317
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 317
gugacguagg caagagugcc uugac                                       25

<210> 318
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 318
gucaaggcac ucuugccuac gucac                                       25

<210> 319
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 319
ugacguaggc aagagugccu ugacg                                       25

<210> 320
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 320
cgucaaggca cucuugccua cguca                                       25

<210> 321
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 321
gacguaggca agagugccuu gacga                                       25

<210> 322
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      hK-ras K12/Asp

<400> 322
ucgucaaggc acucuugccu acguc                                       25

<210> 323
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 323
acuuguggua guuggagcug guugc                                       25

<210> 324
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 324
gcaaccagcu ccaacuacca caagu                                       25

<210> 325
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 325
cuugugguag uuggagcugg uugcg                                       25

<210> 326
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 326
cgcaaccagc uccaacuacc acaag                                       25

<210> 327
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 327
uugugguagu uggagcuggu ugcgu                                       25

<210> 328
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 328
acgucaacag cuccaacuac cacaa                                       25

<210> 329
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 329
ugugguaguu ggagcugguu gcgua                                       25

<210> 330
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 330
uacgucaaca gcuccaacua ccaca                                       25

<210> 331
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 331
gugguaguug gagcugguug cguag                                       25

<210> 332
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 332
cuacgucaac agcuccaacu accac                                       25

<210> 333
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 333
ugguaguugg agcugguugc guagg                                       25

<210> 334
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 334
ccuacgucac cagcuccaac uacca                                       25

<210> 335
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 335
gguaguugga gcugguugcg uaggc                                       25

<210> 336
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 336
gccuacguca ccagcuccaa cuacc                                       25

<210> 337
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 337
guaguuggag cugguugcgu aggca                                       25

<210> 338
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 338
ugccuacguc accagcucca acuac                                       25

<210> 339
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 339
uaguuggagc ugguugcgua ggcaa                                       25

<210> 340
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 340
uugccuacgu caccagcucc aacua                                       25

<210> 341
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 341
aguuggagcu gguugcguag gcaag                                       25

<210> 342
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 342
cuugccuacg ucaccagcuc caacu                                       25

<210> 343
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 343
guuggagcug guugcguagg caaga                                       25

<210> 344
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 344
ucuugccuac gucaccagcu ccaac                                       25

<210> 345
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 345
uuggagcugg uugcguaggc aagag                                       25

<210> 346
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 346
cucuugccua cgucaccagc uccaa                                       25

<210> 347
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 347
uggagcuggu ugcguaggca agagu                                       25

<210> 348
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 348
acucuugccu acgucaccag cucca                                       25

<210> 349
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 349
ggagcugguu gcguaggcaa gagug                                       25

<210> 350
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 350
cacucuugcc uacgucacca gcucc                                       25

<210> 351
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 351
gagcugguug cguaggcaag agugc                                       25

<210> 352
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 352
gcacucuugc cuacgucacc agcuc                                       25

<210> 353
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 353
agcugguugc guaggcaaga gugcc                                       25

<210> 354
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 354
ggcacucuug ccuacgucac cagcu                                       25

<210> 355
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 355
gcugguugcg uaggcaagag ugccu                                       25

<210> 356
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 356
aggcacucuu gccuacguca ccagc                                       25

<210> 357
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 357
cugguugcgu aggcaagagu gccuu                                       25

<210> 358
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 358
aaggcacucu ugccuacguc accag                                       25

<210> 359
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 359
ugguugcgua ggcaagagug ccuug                                       25

<210> 360
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 360
caaggcacuc uugccuacgu cacca                                       25

<210> 361
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 361
gguugcguag gcaagagugc cuuga                                       25

<210> 362
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 362
ucaaggcacu cuugccuacg ucacc                                       25

<210> 363
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 363
guugcguagg caagagugcc uugac                                       25

<210> 364
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 364
gucaaggcac ucuugccuac gucac                                       25

<210> 365
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 365
uugcguaggc aagagugccu ugacg                                       25

<210> 366
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 366
cgucaaggca cucuugccua cgcaa                                       25

<210> 367
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 367
ugcguaggca agagugccuu gacga                                       25

<210> 368
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K13/Cys

<400> 368
ucgucaaggc acucuugccu acgca                                       25

<210> 369
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 369
ggauauucuc gacacagcag gucau                                       25

<210> 370
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 370
augaccugcu gugucgagaa uaucc                                       25

<210> 371
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 371
gauauucucg acacagcagg ucaug                                       25

<210> 372
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 372
caugaccugc ugugucgaga auauc                                       25

<210> 373
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 373
auauucucga cacagcaggu cauga                                       25

<210> 374
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 374
ucaugaccug cugugucgag aauau                                       25

<210> 375
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 375
uauucucgac acagcagguc augag                                       25

<210> 376
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 376
cucaugaccu gcugugucga gaaua                                       25

<210> 377
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 377
auucucgaca cagcagguca ugagg                                       25

<210> 378
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 378
ccucaugacc ugcugugucg agaau                                       25

<210> 379
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 379
uucucgacac agcaggucau gagga                                       25

<210> 380
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 380
uccucaugac cugcuguguc gagaa                                       25

<210> 381
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 381
ucucgacaca gcaggucaug aggag                                       25

<210> 382
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 382
cuccucauga ccugcugugu cgaga                                       25

<210> 383
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 383
cucgacacag caggucauga ggagu                                       25

<210> 384
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 384
acuccucaug accugcugug ucgag                                       25

<210> 385
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 385
ucgacacagc aggucaugag gagua                                       25

<210> 386
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 386
uacuccucau gaccugcugu gucga                                       25

<210> 387
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 387
cgacacagca ggucaugagg aguac                                       25

<210> 388
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 388
guacuccuca ugaccugcug ugucg                                       25

<210> 389
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 389
gacacagcag gucaugagga guaca                                       25

<210> 390
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 390
uguacuccuc augaccugcu guguc                                       25

<210> 391
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 391
acacagcagg ucaugaggag uacag                                       25

<210> 392
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 392
cuguacuccu caugaccugc ugugu                                       25

<210> 393
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 393
cacagcaggu caugaggagu acagu                                       25

<210> 394
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 394
acuguacucc ucaugaccug cugug                                       25

<210> 395
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 395
acagcagguc augaggagua cagug                                       25

<210> 396
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 396
cacuguacuc cucaugaccu gcugu                                       25

<210> 397
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 397
cagcagguca ugaggaguac agugc                                       25

<210> 398
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 398
gcacuguacu ccucaugacc ugcug                                       25

<210> 399
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 399
agcaggucau gaggaguaca gugca                                       25

<210> 400
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 400
ugcacuguac uccucaugac cugcu                                       25

<210> 401
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 401
gcaggucaug aggaguacag ugcaa                                       25

<210> 402
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 402
uugcacugua cuccucauga ccugc                                       25

<210> 403
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 403
caggucauga ggaguacagu gcaau                                       25

<210> 404
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 404
auugcacugu acuccucaug accug                                       25

<210> 405
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 405
aggucaugag gaguacagug caaug                                       25

<210> 406
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 406
cauugcacug uacuccucau gaccu                                       25

<210> 407
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 407
ggucaugagg aguacagugc aauga                                       25

<210> 408
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 408
ucauugcacu guacuccuca ugacc                                       25

<210> 409
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 409
gucaugagga guacagugca augag                                       25

<210> 410
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 410
cucauugcac uguacuccuc augac                                       25

<210> 411
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 411
ucaugaggag uacagugcaa ugagg                                       25

<210> 412
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 412
ccucauugca cuguacuccu cauga                                       25

<210> 413
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 413
caugaggagu acagugcaau gaggg                                       25

<210> 414
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 414
cccucauugc acuguacucc ucaug                                       25

<210> 415
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 415
augaggagua cagugcaaug aggga                                       25

<210> 416
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets mutated
      K-ras K61/His

<400> 416
ucccucauug cacuguacuc cucau                                       25

<210> 417
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 417
uguggacgaa uaugauccaa caaua                                       25

<210> 418
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 418
uauuguugga ucauauucgu ccaca                                       25

<210> 419
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 419
ccaacaauag aggauuccua cagga                                       25

<210> 420
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 420
uccuguagga auccucuauu guugg                                       25

<210> 421
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 421
gagaaaccug ucucuuggau auucu                                       25

<210> 422
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 422
agaauaucca agagacaggu uucuc                                       25

<210> 423
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 423
ggauauucuc gacacagcag gucaa                                       25

<210> 424
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 424
uugaccugcu gugucgagaa uaucc                                       25

<210> 425
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 425
ccuauggucc uaguaggaaa uaaau                                       25

<210> 426
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 426
auuuauuucc uacuaggacc auagg                                       25

<210> 427
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 427
ggcucaggac uuagcaagaa guuau                                       25

<210> 428
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 428
auaacuucuu gcuaaguccu gagcc                                       25

<210> 429
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 429
caggacuuag caagaaguua uggaa                                       25

<210> 430
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 430
uuccauaacu ucuugcuaag uccug                                       25

<210> 431
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 431
acaggguguu gaugaugccu ucuau                                       25

<210> 432
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 432
auagaaggca ucaucaacac ccugu                                       25

<210> 433
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 433
caggguguug augaugccuu cuaua                                       25

<210> 434
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 434
uauagaaggc aucaucaaca cccug                                       25

<210> 435
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 435
gguguugaug augccuucua uacau                                       25

<210> 436
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 436
auguauagaa ggcaucauca acacc                                       25

<210> 437
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 437
aagagugccu ugacgauaca gcuaa                                       25

<210> 438
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 438
uuagcuguau cgucaaggca cucuu                                       25

<210> 439
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 439
agagugccuu gacgauacag cuaau                                       25

<210> 440
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 440
auuagcugua ucgucaaggc acucu                                       25

<210> 441
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 441
ccuugacgau acagcuaauu cagaa                                       25

<210> 442
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 442
uucugaauua gcuguaucgu caagg                                       25

<210> 443
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 443
gacgauacag cuaauucaga aucau                                       25

<210> 444
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 444
augauucuga auuagcugua ucguc                                       25

<210> 445
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 445
ggacgaauau gauccaacaa uagag                                       25

<210> 446
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 446
cucuauuguu ggaucauauu cgucc                                       25

<210> 447
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 447
gauccaacaa uagaggauuc cuaca                                       25

<210> 448
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 448
uguaggaauc cucuauuguu ggauc                                       25

<210> 449
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 449
ggaagcaagu aguaauugau ggaga                                       25

<210> 450
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 450
ucuccaucaa uuacuacuug cuucc                                       25

<210> 451
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 451
gaagcaagua guaauugaug gagaa                                       25

<210> 452
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 452
uucuccauca auuacuacuu gcuuc                                       25

<210> 453
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 453
gaguacagug caaugaggga ccagu                                       25

<210> 454
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 454
acuggucccu cauugcacug uacuc                                       25

<210> 455
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 455
acagugcaau gagggaccag uacau                                       25

<210> 456
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 456
auguacuggu cccucauugc acugu                                       25

<210> 457
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 457
accuaugguc cuaguaggaa auaaa                                       25

<210> 458
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 458
uuuauuuccu acuaggacca uaggu                                       25

<210> 459
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 459
gguccuagua ggaaauaaau gugau                                       25

<210> 460
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 460
aucacauuua uuuccuacua ggacc                                       25

<210> 461
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 461
acaggcucag gacuuagcaa gaagu                                       25

<210> 462
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 462
acuucuugcu aaguccugag ccugu                                       25

<210> 463
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 463
gcucaggacu uagcaagaag uuaug                                       25

<210> 464
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 464
cauaacuucu ugcuaagucc ugagc                                       25

<210> 465
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 465
caggacuuag caagaaguua uggaa                                       25

<210> 466
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 466
uuccauaacu ucuugcuaag uccug                                       25

<210> 467
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 467
aggacuuagc aagaaguuau ggaau                                       25

<210> 468
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 468
auuccauaac uucuugcuaa guccu                                       25

<210> 469
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 469
ggacuuagca agaaguuaug gaauu                                       25

<210> 470
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 470
aauuccauaa cuucuugcua agucc                                       25

<210> 471
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 471
gacagggugu ugaugaugcc uucua                                       25

<210> 472
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 472
uagaaggcau caucaacacc cuguc                                       25

<210> 473
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 473
ggguguugau gaugccuucu auaca                                       25

<210> 474
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule that targets both
      wild-type andd mutated hK-ras

<400> 474
uguauagaag gcaucaucaa caccc                                       25

<210> 475
<211> 5312
<212> DNA
<213> Homo sapiens

<300>
<308>	NCBI GenBank No. NM_004985
<309>	1999-05-14

<400> 475
ggccgcggcg gcggaggcag cagcggcggc ggcagtggcg gcggcgaagg tggcggcggc 60
tcggccagta ctcccggccc ccgccatttc ggactgggag cgagcgcggc gcaggcactg 120
aaggcggcgg cggggccaga ggctcagcgg ctcccaggtg cgggagagag gcctgctgaa 180
aatgactgaa tataaacttg tggtagttgg agctggtggc gtaggcaaga gtgccttgac 240
gatacagcta attcagaatc attttgtgga cgaatatgat ccaacaatag aggattccta 300
caggaagcaa gtagtaattg atggagaaac ctgtctcttg gatattctcg acacagcagg 360
tcaagaggag tacagtgcaa tgagggacca gtacatgagg actggggagg gctttctttg 420
tgtatttgcc ataaataata ctaaatcatt tgaagatatt caccattata gagaacaaat 480
taaaagagtt aaggactctg aagatgtacc tatggtccta gtaggaaata aatgtgattt 540
gccttctaga acagtagaca caaaacaggc tcaggactta gcaagaagtt atggaattcc 600
ttttattgaa acatcagcaa agacaagaca gggtgttgat gatgccttct atacattagt 660
tcgagaaatt cgaaaacata aagaaaagat gagcaaagat ggtaaaaaga agaaaaagaa 720
gtcaaagaca aagtgtgtaa ttatgtaaat acaatttgta cttttttctt aaggcatact 780
agtacaagtg gtaatttttg tacattacac taaattatta gcatttgttt tagcattacc 840
taattttttt cctgctccat gcagactgtt agcttttacc ttaaatgctt attttaaaat 900
gacagtggaa gttttttttt cctctaagtg ccagtattcc cagagttttg gtttttgaac 960
tagcaatgcc tgtgaaaaag aaactgaata cctaagattt ctgtcttggg gtttttggtg 1020
catgcagttg attacttctt atttttctta ccaattgtga atgttggtgt gaaacaaatt 1080
aatgaagctt ttgaatcatc cctattctgt gttttatcta gtcacataaa tggattaatt 1140
actaatttca gttgagacct tctaattggt ttttactgaa acattgaggg aacacaaatt 1200
tatgggcttc ctgatgatga ttcttctagg catcatgtcc tatagtttgt catccctgat 1260
gaatgtaaag ttacactgtt cacaaaggtt ttgtctcctt tccactgcta ttagtcatgg 1320
tcactctccc caaaatatta tattttttct ataaaaagaa aaaaatggaa aaaaattaca 1380
aggcaatgga aactattata aggccatttc cttttcacat tagataaatt actataaaga 1440
ctcctaatag cttttcctgt taaggcagac ccagtatgaa atggggatta ttatagcaac 1500
cattttgggg ctatatttac atgctactaa atttttataa taattgaaaa gattttaaca 1560
agtataaaaa attctcatag gaattaaatg tagtctccct gtgtcagact gctctttcat 1620
agtataactt taaatctttt cttcaacttg agtctttgaa gatagtttta attctgcttg 1680
tgacattaaa agattatttg ggccagttat agcttattag gtgttgaaga gaccaaggtt 1740
gcaaggccag gccctgtgtg aacctttgag ctttcataga gagtttcaca gcatggactg 1800
tgtccccacg gtcatccagt gttgtcatgc attggttagt caaaatgggg agggactagg 1860
gcagtttgga tagctcaaca agatacaatc tcactctgtg gtggtcctgc tgacaaatca 1920
agagcattgc ttttgtttct taagaaaaca aactcttttt taaaaattac ttttaaatat 1980
taactcaaaa gttgagattt tggggtggtg gtgtgccaag acattaattt tttttttaaa 2040
caatgaagtg aaaaagtttt acaatctcta ggtttggcta gttctcttaa cactggttaa 2100
attaacattg cataaacact tttcaagtct gatccatatt taataatgct ttaaaataaa 2160
aataaaaaca atccttttga taaatttaaa atgttactta ttttaaaata aatgaagtga 2220
gatggcatgg tgaggtgaaa gtatcactgg actaggaaga aggtgactta ggttctagat 2280
aggtgtcttt taggactctg attttgagga catcacttac tatccatttc ttcatgttaa 2340
aagaagtcat ctcaaactct tagttttttt tttttacaac tatgtaattt atattccatt 2400
tacataagga tacacttatt tgtcaagctc agcacaatct gtaaattttt aacctatgtt 2460
acaccatctt cagtgccagt cttgggcaaa attgtgcaag aggtgaagtt tatatttgaa 2520
tatccattct cgttttagga ctcttcttcc atattagtgt catcttgcct ccctaccttc 2580
cacatgcccc atgacttgat gcagttttaa tacttgtaat tcccctaacc ataagattta 2640
ctgctgctgt ggatatctcc atgaagtttt cccactgagt cacatcagaa atgccctaca 2700
tcttatttcc tcagggctca agagaatctg acagatacca taaagggatt tgacctaatc 2760
actaattttc aggtggtggc tgatgctttg aacatctctt tgctgcccaa tccattagcg 2820
acagtaggat ttttcaaacc tggtatgaat agacagaacc ctatccagtg gaaggagaat 2880
ttaataaaga tagtgctgaa agaattcctt aggtaatcta taactaggac tactcctggt 2940
aacagtaata cattccattg ttttagtaac cagaaatctt catgcaatga aaaatacttt 3000
aattcatgaa gcttactttt tttttttggt gtcagagtct cgctcttgtc acccaggctg 3060
gaatgcagtg gcgccatctc agctcactgc aacctccatc tcccaggttc aagcgattct 3120
cgtgcctcgg cctcctgagt agctgggatt acaggcgtgt gccactacac tcaactaatt 3180
tttgtatttt taggagagac ggggtttcac cctgttggcc aggctggtct cgaactcctg 3240
acctcaagtg attcacccac cttggcctca taaacctgtt ttgcagaact catttattca 3300
gcaaatattt attgagtgcc taccagatgc cagtcaccgc acaaggcact gggtatatgg 3360
tatccccaaa caagagacat aatcccggtc cttaggtagt gctagtgtgg tctgtaatat 3420
cttactaagg cctttggtat acgacccaga gataacacga tgcgtatttt agttttgcaa 3480
agaaggggtt tggtctctgt gccagctcta taattgtttt gctacgattc cactgaaact 3540
cttcgatcaa gctactttat gtaaatcact tcattgtttt aaaggaataa acttgattat 3600
attgtttttt tatttggcat aactgtgatt cttttaggac aattactgta cacattaagg 3660
tgtatgtcag atattcatat tgacccaaat gtgtaatatt ccagttttct ctgcataagt 3720
aattaaaata tacttaaaaa ttaatagttt tatctgggta caaataaaca ggtgcctgaa 3780
ctagttcaca gacaaggaaa cttctatgta aaaatcacta tgatttctga attgctatgt 3840
gaaactacag atctttggaa cactgtttag gtagggtgtt aagacttaca cagtacctcg 3900
tttctacaca gagaaagaaa tggccatact tcaggaactg cagtgcttat gaggggatat 3960
ttaggcctct tgaatttttg atgtagatgg gcattttttt aaggtagtgg ttaattacct 4020
ttatgtgaac tttgaatggt ttaacaaaag atttgttttt gtagagattt taaaggggga 4080
gaattctaga aataaatgtt acctaattat tacagcctta aagacaaaaa tccttgttga 4140
agttttttta aaaaaagcta aattacatag acttaggcat taacatgttt gtggaagaat 4200
atagcagacg tatattgtat catttgagtg aatgttccca agtaggcatt ctaggctcta 4260
tttaactgag tcacactgca taggaattta gaacctaact tttataggtt atcaaaactg 4320
ttgtcaccat tgcacaattt tgtcctaata tatacataga aactttgtgg ggcatgttaa 4380
gttacagttt gcacaagttc atctcatttg tattccattg attttttttt tcttctaaac 4440
attttttctt caaacagtat ataacttttt ttaggggatt tttttttaga cagcaaaaac 4500
tatctgaaga tttccatttg tcaaaaagta atgatttctt gataattgtg tagtaatgtt 4560
ttttagaacc cagcagttac cttaaagctg aatttatatt tagtaacttc tgtgttaata 4620
ctggatagca tgaattctgc attgagaaac tgaatagctg tcataaaatg aaactttctt 4680
tctaaagaaa gatactcaca tgagttcttg aagaatagtc ataactagat taagatctgt 4740
gttttagttt aatagtttga agtgcctgtt tgggataatg ataggtaatt tagatgaatt 4800
taggggaaaa aaaagttatc tgcagatatg ttgagggccc atctctcccc ccacaccccc 4860
acagagctaa ctgggttaca gtgttttatc cgaaagtttc caattccact gtcttgtgtt 4920
ttcatgttga aaatactttt gcatttttcc tttgagtgcc aatttcttac tagtactatt 4980
tcttaatgta acatgtttac ctggaatgta ttttaactat ttttgtatag tgtaaactga 5040
aacatgcaca ttttgtacat tgtgctttct tttgtgggac atatgcagtg tgatccagtt 5100
gttttccatc atttggttgc gctgacctag gaatgttggt catatcaaac attaaaaatg 5160
accactcttt taattgaaat taacttttaa atgtttatag gagtatgtgc tgtgaagtga 5220
tctaaaattt gtaatatttt tgtcatgaac tgtactactc ctaattattg taatgtaata 5280
aaaatagtta cagtgacaaa aaaaaaaaaa aa                               5312



<210> 476
<211> 1567
<212> DNA
<213> Mus musculus

<300>
<308>	NCBI GenBank No. BC004642
<309>	2001-03-21


<400> 476
cggacgcgtg ggcggcagcg ctgtggcggc ggctgagacg gcaggggaag gcggcggcgg 60
ctcggcccgg agtcccgctc ccgcgccatt tcggacccgg agcgagcgcg gcgcgggcct 120
gaaggcggcg gcgggagcct gaggcgcggc ggctccgcgg cgcggagaga ggcctgctga 180
aaatgactga gtataaactt gtggtggttg gagctggtgg cgtaggcaag agcgccttga 240
cgatacagct aattcagaat cactttgtgg atgagtacga ccctacgata gaggactcct 300
acaggaaaca agtagtaatt gatggagaaa cctgtctctt ggatattctc gacacagcag 360
gtcaagagga gtacagtgca atgagggacc agtacatgag aactggggag ggctttcttt 420
gtgtatttgc cataaataat actaaatcat ttgaagatat tcaccattat agagaacaaa 480
ttaaaagagt aaaggactct gaagatgtgc ctatggtcct ggtagggaat aagtgtgatt 540
tgccttctag aacagtagac acgaaacagg ctcaggagtt agcaaggagt tacgggattc 600
cgttcattga gacctcagca aagacaagac agggtgttga cgatgccttc tatacattag 660
tccgagaaat tcgaaaacat aaagaaaaga tgagcaaaga tgggaagaag aagaagaaga 720
agtcaaggac aaggtgtaca gttatgtgaa tactttgtac tctttcttaa ggcacactta 780
agtaaaagtg tgatttttgt acattacact aaattattag catttgtttt agcattacct 840
aatctttttt ttttcttctg ttcgtgcaaa ctgtcagctt ttatctcaaa tgcttatttt 900
aaaagaacag tggaaacctt cttttttcta agtgccagta ttccctgggt tttggactta 960
aactagcaat gcctgtggaa gagactaaag acctgagact ctgtcttggg atttggtgca 1020
tgcagttgat tccttgctag ttctcttacc aactgtgaac actgatggga agcaggataa 1080
tgaagcttcc ggaccatccc tgctctgtgt ccatctactc atccaatgga gtcattagca 1140
gtcaatcgca gcttcactgg acactgaggg gtcacagact taggctccct ttgagtcacg 1200
tccagcgtgt cctagacttt atcatctttc agaggcgtag gcagactgtt cacaaaggct 1260
ttctctagct ttccactgca attaatcttg gtcactccct caaatagtat attttttcta 1320
gaaaagggga aaaatggaaa aaaaaaaaaa ggcaatggaa aatgttgaaa tccattcagt 1380
ttccatgtta gctaaattac tgtaagattc ctataatagc ttttcctggt aaggcagacc 1440
cagtatgaaa tagtaataac catttgggct atatttacat gctactaaat ttttgtaata 1500
attcaaacaa ctttagcata tataaaaagt tctcataaga attaagtaca aaaaaaaaaa 1560
aaaaaaa                                                           1567

<210> 477
<211> 188
<212> PRT
<213> Homo sapiens

<400> 477
Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys
 1               5                  10                  15      
Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr
            20                  25                  30          
Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly
        35                  40                  45              
Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr
    50                  55                  60                  
Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys
65                  70                  75                  80  
Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr
                85                  90                  95      
Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val
            100                 105                 110         
Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys
        115                 120                 125             
Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr
    130                 135                 140                 
Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val
145                 150                 155                 160 
Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys
                165                 170                 175     
Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met
            180                 185             


<210> 478
<211> 188
<212> PRT
<213> Mus musculus

<400> 478
Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys
 1               5                  10                  15      
Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr
            20                  25                  30          
Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly
        35                  40                  45              
Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr
    50                  55                  60                  
Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys
65                  70                  75                  80  
Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr
                85                  90                  95      
Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val
            100                 105                 110         
Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys
        115                 120                 125             
Gln Ala Gln Glu Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr
    130                 135                 140                 
Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val
145                 150                 155                 160 
Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys
                165                 170                 175     
Lys Lys Lys Lys Ser Arg Thr Arg Cys Thr Val Met
            180                 185             


<210> 479
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule

<400> 479
guuggagcug guggcguagg caaga                                       25

<210> 480
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule

<400> 480
caaccucgac aaccgcaucc guucu                                       25

<210> 481
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule

<400> 481
cuugugguag uuggagcugu ugacg                                       25

<210> 482
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule

<400> 482
cgucaacagc uccaacuacc acaag                                       25

<210> 483
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule

<400> 483
uugugguagu uggagcuguu gacgu                                       25

<210> 484
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule

<400> 484
acgucaacag cuccaacuac cacaa                                       25

<210> 485
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule

<400> 485
ugugguaguu ggagcuguug acgua                                       25

<210> 486
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule

<400> 486
uacgucaaca gcuccaacua ccaca                                       25

<210> 487
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule

<400> 487
gugguaguug gagcuguuga cguag                                       25

<210> 488
<211> 25
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthesized siRNA molecule

<400> 488
cuacgucaac agcuccaacu accac                                       25
