                               SEQUENCE LISTING

<110> STRYKER CORPORATION
 
<120> METHOD OF TREATING VASCULAR SCLEROSIS

<130> 003443.0096.WO1

<140>
<141>

<150> 61/028,499
<151> 2008-02-13

<160> 68    

<170> PatentIn version 3.5

<210> 1
<211> 431
<212> PRT
<213> Homo sapiens

<400> 1
Met His Val Arg Ser Leu Arg Ala Ala Ala Pro His Ser Phe Val Ala 
1               5                   10                  15      


Leu Trp Ala Pro Leu Phe Leu Leu Arg Ser Ala Leu Ala Asp Phe Ser 
            20                  25                  30          


Leu Asp Asn Glu Val His Ser Ser Phe Ile His Arg Arg Leu Arg Ser 
        35                  40                  45              


Gln Glu Arg Arg Glu Met Gln Arg Glu Ile Leu Ser Ile Leu Gly Leu 
    50                  55                  60                  


Pro His Arg Pro Arg Pro His Leu Gln Gly Lys His Asn Ser Ala Pro 
65                  70                  75                  80  


Met Phe Met Leu Asp Leu Tyr Asn Ala Met Ala Val Glu Glu Gly Gly 
                85                  90                  95      


Gly Pro Gly Gly Gln Gly Phe Ser Tyr Pro Tyr Lys Ala Val Phe Ser 
            100                 105                 110         


Thr Gln Gly Pro Pro Leu Ala Ser Leu Gln Asp Ser His Phe Leu Thr 
        115                 120                 125             


Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu His Asp Lys 
    130                 135                 140                 


Glu Phe Phe His Pro Arg Tyr His His Arg Glu Phe Arg Phe Asp Leu 
145                 150                 155                 160 


Ser Lys Ile Pro Glu Gly Glu Ala Val Thr Ala Ala Glu Phe Arg Ile 
                165                 170                 175     


Tyr Lys Asp Tyr Ile Arg Glu Arg Phe Asp Asn Glu Thr Phe Arg Ile 
            180                 185                 190         


Ser Val Tyr Gln Val Leu Gln Glu His Leu Gly Arg Glu Ser Asp Leu 
        195                 200                 205             


Phe Leu Leu Asp Ser Arg Thr Leu Trp Ala Ser Glu Glu Gly Trp Leu 
    210                 215                 220                 


Val Phe Asp Ile Thr Ala Thr Ser Asn His Trp Val Val Asn Pro Arg 
225                 230                 235                 240 


His Asn Leu Gly Leu Gln Leu Ser Val Glu Thr Leu Asp Gly Gln Ser 
                245                 250                 255     


Ile Asn Pro Lys Leu Ala Gly Leu Ile Gly Arg His Gly Pro Gln Asn 
            260                 265                 270         


Lys Gln Pro Phe Met Val Ala Phe Phe Lys Ala Thr Glu Val His Phe 
        275                 280                 285             


Arg Ser Ile Arg Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser 
    290                 295                 300                 


Lys Thr Pro Lys Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu 
305                 310                 315                 320 


Asn Ser Ser Ser Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr 
                325                 330                 335     


Val Ser Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu 
            340                 345                 350         


Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn 
        355                 360                 365             


Ser Tyr Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His 
    370                 375                 380                 


Phe Ile Asn Pro Glu Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln 
385                 390                 395                 400 


Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile 
                405                 410                 415     


Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
            420                 425                 430     


<210> 2
<211> 97
<212> PRT
<213> Homo sapiens

<400> 2
Leu Tyr Val Ser Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala 
1               5                   10                  15      


Pro Glu Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro 
            20                  25                  30          


Leu Asn Ser Tyr Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu 
        35                  40                  45              


Val His Phe Ile Asn Pro Glu Thr Val Pro Lys Pro Cys Cys Ala Pro 
    50                  55                  60                  


Thr Gln Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn 
65                  70                  75                  80  


Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys 
                85                  90                  95      


His 
    


<210> 3
<211> 139
<212> PRT
<213> Homo sapiens

<400> 3
Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser Lys Thr Pro Lys 
1               5                   10                  15      


Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu Asn Ser Ser Ser 
            20                  25                  30          


Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg 
        35                  40                  45              


Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala 
    50                  55                  60                  


Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn Ser Tyr Met Asn 
65                  70                  75                  80  


Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His Phe Ile Asn Pro 
                85                  90                  95      


Glu Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln Leu Asn Ala Ile 
            100                 105                 110         


Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr 
        115                 120                 125             


Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
    130                 135                 


<210> 4
<211> 430
<212> PRT
<213> Mus sp.

<400> 4
Met His Val Arg Ser Leu Arg Ala Ala Ala Pro His Ser Phe Val Ala 
1               5                   10                  15      


Leu Trp Ala Pro Leu Phe Leu Leu Arg Ser Ala Leu Ala Asp Phe Ser 
            20                  25                  30          


Leu Asp Asn Glu Val His Ser Ser Phe Ile His Arg Arg Leu Arg Ser 
        35                  40                  45              


Gln Glu Arg Arg Glu Met Gln Arg Glu Ile Leu Ser Ile Leu Gly Leu 
    50                  55                  60                  


Pro His Arg Pro Arg Pro His Leu Gln Gly Lys His Asn Ser Ala Pro 
65                  70                  75                  80  


Met Phe Met Leu Asp Leu Tyr Asn Ala Met Ala Val Glu Glu Ser Gly 
                85                  90                  95      


Pro Asp Gly Gln Gly Phe Ser Tyr Pro Tyr Lys Ala Val Phe Ser Thr 
            100                 105                 110         


Gln Gly Pro Pro Leu Ala Ser Leu Gln Asp Ser His Phe Leu Thr Asp 
        115                 120                 125             


Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu His Asp Lys Glu 
    130                 135                 140                 


Phe Phe His Pro Arg Tyr His His Arg Glu Phe Arg Phe Asp Leu Ser 
145                 150                 155                 160 


Lys Ile Pro Glu Gly Glu Ala Val Thr Ala Ala Glu Phe Arg Ile Tyr 
                165                 170                 175     


Lys Asp Tyr Ile Arg Glu Arg Phe Asp Asn Glu Thr Phe Gln Ile Thr 
            180                 185                 190         


Val Tyr Gln Val Leu Gln Glu His Ser Gly Arg Glu Ser Asp Leu Phe 
        195                 200                 205             


Leu Leu Asp Ser Arg Thr Ile Trp Ala Ser Glu Glu Gly Trp Leu Val 
    210                 215                 220                 


Phe Asp Ile Thr Ala Thr Ser Asn His Trp Val Val Asn Pro Arg His 
225                 230                 235                 240 


Asn Leu Gly Leu Gln Leu Ser Val Glu Thr Leu Asp Gly Gln Ser Ile 
                245                 250                 255     


Asn Pro Lys Leu Ala Gly Leu Ile Gly Arg His Gly Pro Gln Asn Lys 
            260                 265                 270         


Gln Pro Phe Met Val Ala Phe Phe Lys Ala Thr Glu Val His Leu Arg 
        275                 280                 285             


Ser Ile Arg Ser Thr Gly Gly Lys Gln Arg Ser Gln Asn Arg Ser Lys 
    290                 295                 300                 


Thr Pro Lys Asn Gln Glu Ala Leu Arg Met Ala Ser Val Ala Glu Asn 
305                 310                 315                 320 


Ser Ser Ser Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr Val 
                325                 330                 335     


Ser Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu Gly 
            340                 345                 350         


Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn Ser 
        355                 360                 365             


Tyr Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His Phe 
    370                 375                 380                 


Ile Asn Pro Asp Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln Leu 
385                 390                 395                 400 


Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile Leu 
                405                 410                 415     


Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
            420                 425                 430 


<210> 5
<211> 139
<212> PRT
<213> Homo sapiens

<400> 5
Ala Val Arg Pro Leu Arg Arg Arg Gln Pro Lys Lys Ser Asn Glu Leu 
1               5                   10                  15      


Pro Gln Ala Asn Arg Leu Pro Gly Ile Phe Asp Asp Val His Gly Ser 
            20                  25                  30          


His Gly Arg Gln Val Cys Arg Arg His Glu Leu Tyr Val Ser Phe Gln 
        35                  40                  45              


Asp Leu Gly Trp Leu Asp Trp Val Ile Ala Pro Gln Gly Tyr Ser Ala 
    50                  55                  60                  


Tyr Tyr Cys Glu Gly Glu Cys Ser Phe Pro Leu Asp Ser Cys Met Asn 
65                  70                  75                  80  


Ala Thr Asn His Ala Ile Leu Gln Ser Leu Val His Leu Met Met Pro 
                85                  90                  95      


Asp Ala Val Pro Lys Ala Cys Cys Ala Pro Thr Lys Leu Ser Ala Thr 
            100                 105                 110         


Ser Val Leu Tyr Tyr Asp Ser Ser Asn Asn Val Ile Leu Arg Lys His 
        115                 120                 125             


Arg Asn Met Val Val Lys Ala Cys Gly Cys His 
    130                 135                 


<210> 6
<211> 139
<212> PRT
<213> Mus sp.

<400> 6
Ala Ala Arg Pro Leu Lys Arg Arg Gln Pro Lys Lys Thr Asn Glu Leu 
1               5                   10                  15      


Pro His Pro Asn Lys Leu Pro Gly Ile Phe Asp Asp Gly His Gly Ser 
            20                  25                  30          


Arg Gly Arg Glu Val Cys Arg Arg His Glu Leu Tyr Val Ser Phe Arg 
        35                  40                  45              


Asp Leu Gly Trp Leu Asp Trp Val Ile Ala Pro Gln Gly Tyr Ser Ala 
    50                  55                  60                  


Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asp Ser Cys Met Asn 
65                  70                  75                  80  


Ala Thr Asn His Ala Ile Leu Gln Ser Leu Val His Leu Met Lys Pro 
                85                  90                  95      


Asp Val Val Pro Lys Ala Cys Cys Ala Pro Thr Lys Leu Ser Ala Thr 
            100                 105                 110         


Ser Val Leu Tyr Tyr Asp Ser Ser Asn Asn Val Ile Leu Arg Lys His 
        115                 120                 125             


Arg Asn Met Val Val Lys Ala Cys Gly Cys His 
    130                 135                 


<210> 7
<211> 588
<212> PRT
<213> Drosophila sp.

<400> 7
Met Arg Ala Trp Leu Leu Leu Leu Ala Val Leu Ala Thr Phe Gln Thr 
1               5                   10                  15      


Ile Val Arg Val Ala Ser Thr Glu Asp Ile Ser Gln Arg Phe Ile Ala 
            20                  25                  30          


Ala Ile Ala Pro Val Ala Ala His Ile Pro Leu Ala Ser Ala Ser Gly 
        35                  40                  45              


Ser Gly Ser Gly Arg Ser Gly Ser Arg Ser Gly Gly Ala Ser Thr Ser 
    50                  55                  60                  


Thr Ala Leu Ala Lys Ala Phe Asn Pro Phe Ser Glu Pro Ala Ser Phe 
65                  70                  75                  80  


Ser Asp Ser Asp Lys Ser His Arg Ser Lys Thr Asn Lys Lys Pro Ser 
                85                  90                  95      


Lys Ser Asp Ala Asn Arg Gln Phe Asn Glu Val His Lys Pro Arg Thr 
            100                 105                 110         


Asp Gln Leu Glu Asn Ser Lys Asn Met Ser Lys Gln Leu Val Asn Lys 
        115                 120                 125             


Pro Asn His Asn Lys Met Ala Val Lys Glu Gln Arg Ser His His Lys 
    130                 135                 140                 


Lys Ser His His His Arg Ser His Gln Pro Lys Gln Ala Ser Ala Ser 
145                 150                 155                 160 


Thr Glu Ser His Gln Ser Ser Ser Ile Glu Ser Ile Phe Val Glu Glu 
                165                 170                 175     


Pro Thr Leu Val Leu Asp Arg Glu Val Ala Ser Ile Asn Val Pro Ala 
            180                 185                 190         


Asn Ala Lys Ala Ile Ile Ala Glu Gln Gly Pro Ser Thr Tyr Ser Lys 
        195                 200                 205             


Glu Ala Leu Ile Lys Asp Lys Leu Lys Pro Asp Pro Ser Thr Leu Val 
    210                 215                 220                 


Glu Ile Glu Lys Ser Leu Leu Ser Leu Phe Asn Met Lys Arg Pro Pro 
225                 230                 235                 240 


Lys Ile Asp Arg Ser Lys Ile Ile Ile Pro Glu Pro Met Lys Lys Leu 
                245                 250                 255     


Tyr Ala Glu Ile Met Gly His Glu Leu Asp Ser Val Asn Ile Pro Lys 
            260                 265                 270         


Pro Gly Leu Leu Thr Lys Ser Ala Asn Thr Val Arg Ser Phe Thr His 
        275                 280                 285             


Lys Asp Ser Lys Ile Asp Asp Arg Phe Pro His His His Arg Phe Arg 
    290                 295                 300                 


Leu His Phe Asp Val Lys Ser Ile Pro Ala Asp Glu Lys Leu Lys Ala 
305                 310                 315                 320 


Ala Glu Leu Gln Leu Thr Arg Asp Ala Leu Ser Gln Gln Val Val Ala 
                325                 330                 335     


Ser Arg Ser Ser Ala Asn Arg Thr Arg Tyr Gln Val Leu Val Tyr Asp 
            340                 345                 350         


Ile Thr Arg Val Gly Val Arg Gly Gln Arg Glu Pro Ser Tyr Leu Leu 
        355                 360                 365             


Leu Asp Thr Lys Thr Val Arg Leu Asn Ser Thr Asp Thr Val Ser Leu 
    370                 375                 380                 


Asp Val Gln Pro Ala Val Asp Arg Trp Leu Ala Ser Pro Gln Arg Asn 
385                 390                 395                 400 


Tyr Gly Leu Leu Val Glu Val Arg Thr Val Arg Ser Leu Lys Pro Ala 
                405                 410                 415     


Pro His His His Val Arg Leu Arg Arg Ser Ala Asp Glu Ala His Glu 
            420                 425                 430         


Arg Trp Gln His Lys Gln Pro Leu Leu Phe Thr Tyr Thr Asp Asp Gly 
        435                 440                 445             


Arg His Lys Ala Arg Ser Ile Arg Asp Val Ser Gly Gly Glu Gly Gly 
    450                 455                 460                 


Gly Lys Gly Gly Arg Asn Lys Arg Gln Pro Arg Arg Pro Thr Arg Arg 
465                 470                 475                 480 


Lys Asn His Asp Asp Thr Cys Arg Arg His Ser Leu Tyr Val Asp Phe 
                485                 490                 495     


Ser Asp Val Gly Trp Asp Asp Trp Ile Val Ala Pro Leu Gly Tyr Asp 
            500                 505                 510         


Ala Tyr Tyr Cys His Gly Lys Cys Pro Phe Pro Leu Ala Asp His Phe 
        515                 520                 525             


Asn Ser Thr Asn His Ala Val Val Gln Thr Leu Val Asn Asn Met Asn 
    530                 535                 540                 


Pro Gly Lys Val Pro Lys Ala Cys Cys Val Pro Thr Gln Leu Asp Ser 
545                 550                 555                 560 


Val Ala Met Leu Tyr Leu Asn Asp Gln Ser Thr Val Val Leu Lys Asn 
                565                 570                 575     


Tyr Gln Glu Met Thr Val Val Gly Cys Gly Cys Arg 
            580                 585             


<210> 8
<211> 360
<212> PRT
<213> Xenopus sp.

<400> 8
Met Val Trp Leu Arg Leu Trp Ala Phe Leu His Ile Leu Ala Ile Val 
1               5                   10                  15      


Thr Leu Asp Pro Glu Leu Lys Arg Arg Glu Glu Leu Phe Leu Arg Ser 
            20                  25                  30          


Leu Gly Phe Ser Ser Lys Pro Asn Pro Val Ser Pro Pro Pro Val Pro 
        35                  40                  45              


Ser Ile Leu Trp Arg Ile Phe Asn Gln Arg Met Gly Ser Ser Ile Gln 
    50                  55                  60                  


Lys Lys Lys Pro Asp Leu Cys Phe Val Glu Glu Phe Asn Val Pro Gly 
65                  70                  75                  80  


Ser Val Ile Arg Val Phe Pro Asp Gln Gly Arg Phe Ile Ile Pro Tyr 
                85                  90                  95      


Ser Asp Asp Ile His Pro Thr Gln Cys Leu Glu Lys Arg Leu Phe Phe 
            100                 105                 110         


Asn Ile Ser Ala Ile Glu Lys Glu Glu Arg Val Thr Met Gly Ser Gly 
        115                 120                 125             


Ile Glu Val Gln Pro Glu His Leu Leu Arg Lys Gly Ile Asp Leu Arg 
    130                 135                 140                 


Leu Tyr Arg Thr Leu Gln Ile Thr Leu Lys Gly Met Gly Arg Ser Lys 
145                 150                 155                 160 


Thr Ser Arg Lys Leu Leu Val Ala Gln Thr Phe Arg Leu Leu His Lys 
                165                 170                 175     


Ser Leu Phe Phe Asn Leu Thr Glu Ile Cys Gln Ser Trp Gln Asp Pro 
            180                 185                 190         


Leu Lys Asn Leu Gly Leu Val Leu Glu Ile Phe Pro Lys Lys Glu Ser 
        195                 200                 205             


Ser Trp Met Ser Thr Ala Asn Asp Glu Cys Lys Asp Ile Gln Thr Phe 
    210                 215                 220                 


Leu Tyr Thr Ser Leu Leu Thr Val Thr Leu Asn Pro Leu Arg Cys Lys 
225                 230                 235                 240 


Arg Pro Arg Arg Lys Arg Ser Tyr Ser Lys Leu Pro Phe Thr Ala Ser 
                245                 250                 255     


Asn Ile Cys Lys Lys Arg His Leu Tyr Val Glu Phe Lys Asp Val Gly 
            260                 265                 270         


Trp Gln Asn Trp Val Ile Ala Pro Gln Gly Tyr Met Ala Asn Tyr Cys 
        275                 280                 285             


Tyr Gly Glu Cys Pro Tyr Pro Leu Thr Glu Ile Leu Asn Gly Ser Asn 
    290                 295                 300                 


His Ala Ile Leu Gln Thr Leu Val His Ser Ile Glu Pro Glu Asp Ile 
305                 310                 315                 320 


Pro Leu Pro Cys Cys Val Pro Thr Lys Met Ser Pro Ile Ser Met Leu 
                325                 330                 335     


Phe Tyr Asp Asn Asn Asp Asn Val Val Leu Arg His Tyr Glu Asn Met 
            340                 345                 350         


Ala Val Asp Glu Cys Gly Cys Arg 
        355                 360 


<210> 9
<211> 438
<212> PRT
<213> Mus sp.

<400> 9
Met Arg Lys Met Gln Lys Glu Ile Leu Ser Val Leu Gly Pro Pro His 
1               5                   10                  15      


Arg Pro Arg Pro Leu His Gly Leu Gln Gln Pro Gln Pro Pro Val Leu 
            20                  25                  30          


Pro Pro Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Thr Ala Arg Glu 
        35                  40                  45              


Glu Pro Pro Pro Gly Arg Leu Lys Ser Ala Pro Leu Phe Met Leu Asp 
    50                  55                  60                  


Leu Tyr Asn Ala Leu Ser Asn Asp Asp Glu Glu Asp Gly Ala Ser Glu 
65                  70                  75                  80  


Gly Val Gly Gln Glu Pro Gly Ser His Gly Gly Ala Ser Ser Ser Gln 
                85                  90                  95      


Leu Arg Gln Pro Ser Pro Gly Ala Ala His Ser Leu Asn Arg Lys Ser 
            100                 105                 110         


Leu Leu Ala Pro Gly Pro Gly Gly Gly Ala Ser Pro Leu Thr Ser Ala 
        115                 120                 125             


Gln Asp Ser Ala Phe Leu Asn Asp Ala Asp Met Val Met Ser Phe Val 
    130                 135                 140                 


Asn Leu Val Glu Tyr Asp Lys Glu Phe Ser Pro His Gln Arg His His 
145                 150                 155                 160 


Lys Glu Phe Lys Phe Asn Leu Ser Gln Ile Pro Glu Gly Glu Ala Val 
                165                 170                 175     


Thr Ala Ala Glu Phe Arg Val Tyr Lys Asp Cys Val Val Gly Ser Phe 
            180                 185                 190         


Lys Asn Gln Thr Phe Leu Ile Ser Ile Tyr Gln Val Leu Gln Glu His 
        195                 200                 205             


Gln His Arg Asp Ser Asp Leu Phe Leu Leu Asp Thr Arg Val Val Trp 
    210                 215                 220                 


Ala Ser Glu Glu Gly Trp Leu Glu Phe Asp Ile Thr Ala Thr Ser Asn 
225                 230                 235                 240 


Leu Trp Val Val Thr Pro Gln His Asn Met Gly Leu Gln Leu Ser Val 
                245                 250                 255     


Val Thr Arg Asp Gly Leu His Val Asn Pro Arg Ala Ala Gly Leu Val 
            260                 265                 270         


Gly Arg Asp Gly Pro Tyr Asp Lys Gln Pro Phe Met Val Ala Phe Phe 
        275                 280                 285             


Lys Val Ser Glu Val His Val Arg Thr Thr Arg Ser Ala Ser Ser Arg 
    290                 295                 300                 


Arg Arg Gln Gln Ser Arg Asn Arg Ser Thr Gln Ser Gln Asp Val Ser 
305                 310                 315                 320 


Arg Gly Ser Gly Ser Ser Asp Tyr Asn Gly Ser Glu Leu Lys Thr Ala 
                325                 330                 335     


Cys Lys Lys His Glu Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Gln 
            340                 345                 350         


Asp Trp Ile Ile Ala Pro Lys Gly Tyr Ala Ala Asn Tyr Cys Asp Gly 
        355                 360                 365             


Glu Cys Ser Phe Pro Leu Asn Ala His Met Asn Ala Thr Asn His Ala 
    370                 375                 380                 


Ile Val Gln Thr Leu Val His Leu Met Asn Pro Glu Tyr Val Pro Lys 
385                 390                 395                 400 


Pro Cys Cys Ala Pro Thr Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe 
                405                 410                 415     


Asp Asp Asn Ser Asn Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val 
            420                 425                 430         


Arg Ala Cys Gly Cys His 
        435             


<210> 10
<211> 396
<212> PRT
<213> Homo sapiens

<400> 10
Met Val Ala Gly Thr Arg Cys Leu Leu Ala Leu Leu Leu Pro Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ala Gly Leu Val Pro Glu Leu Gly Arg Arg Lys 
            20                  25                  30          


Phe Ala Ala Ala Ser Ser Gly Arg Pro Ser Ser Gln Pro Ser Asp Glu 
        35                  40                  45              


Val Leu Ser Glu Phe Glu Leu Arg Leu Leu Ser Met Phe Gly Leu Lys 
    50                  55                  60                  


Gln Arg Pro Thr Pro Ser Arg Asp Ala Val Val Pro Pro Tyr Met Leu 
65                  70                  75                  80  


Asp Leu Tyr Arg Arg His Ser Gly Gln Pro Gly Ser Pro Ala Pro Asp 
                85                  90                  95      


His Arg Leu Glu Arg Ala Ala Ser Arg Ala Asn Thr Val Arg Ser Phe 
            100                 105                 110         


His His Glu Glu Ser Leu Glu Glu Leu Pro Glu Thr Ser Gly Lys Thr 
        115                 120                 125             


Thr Arg Arg Phe Phe Phe Asn Leu Ser Ser Ile Pro Thr Glu Glu Phe 
    130                 135                 140                 


Ile Thr Ser Ala Glu Leu Gln Val Phe Arg Glu Gln Met Gln Asp Ala 
145                 150                 155                 160 


Leu Gly Asn Asn Ser Ser Phe His His Arg Ile Asn Ile Tyr Glu Ile 
                165                 170                 175     


Ile Lys Pro Ala Thr Ala Asn Ser Lys Phe Pro Val Thr Arg Leu Leu 
            180                 185                 190         


Asp Thr Arg Leu Val Asn Gln Asn Ala Ser Arg Trp Glu Ser Phe Asp 
        195                 200                 205             


Val Thr Pro Ala Val Met Arg Trp Thr Ala Gln Gly His Ala Asn His 
    210                 215                 220                 


Gly Phe Val Val Glu Val Ala His Leu Glu Glu Lys Gln Gly Val Ser 
225                 230                 235                 240 


Lys Arg His Val Arg Ile Ser Arg Ser Leu His Gln Asp Glu His Ser 
                245                 250                 255     


Trp Ser Gln Ile Arg Pro Leu Leu Val Thr Phe Gly His Asp Gly Lys 
            260                 265                 270         


Gly His Pro Leu His Lys Arg Glu Lys Arg Gln Ala Lys His Lys Gln 
        275                 280                 285             


Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
    290                 295                 300                 


Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
305                 310                 315                 320 


His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
                325                 330                 335     


Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val 
            340                 345                 350         


Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 
        355                 360                 365             


Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
    370                 375                 380                 


Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
385                 390                 395     


<210> 11
<211> 408
<212> PRT
<213> Homo sapiens

<400> 11
Met Ile Pro Gly Asn Arg Met Leu Met Val Val Leu Leu Cys Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ser His Ala Ser Leu Ile Pro Glu Thr Gly Lys 
            20                  25                  30          


Lys Lys Val Ala Glu Ile Gln Gly His Ala Gly Gly Arg Arg Ser Gly 
        35                  40                  45              


Gln Ser His Glu Leu Leu Arg Asp Phe Glu Ala Thr Leu Leu Gln Met 
    50                  55                  60                  


Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile Pro 
65                  70                  75                  80  


Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu Glu 
                85                  90                  95      


Glu Gln Ile His Ser Thr Gly Leu Glu Tyr Pro Glu Arg Pro Ala Ser 
            100                 105                 110         


Arg Ala Asn Thr Val Arg Ser Phe His His Glu Glu His Leu Glu Asn 
        115                 120                 125             


Ile Pro Gly Thr Ser Glu Asn Ser Ala Phe Arg Phe Leu Phe Asn Leu 
    130                 135                 140                 


Ser Ser Ile Pro Glu Asn Glu Val Ile Ser Ser Ala Glu Leu Arg Leu 
145                 150                 155                 160 


Phe Arg Glu Gln Val Asp Gln Gly Pro Asp Trp Glu Arg Gly Phe His 
                165                 170                 175     


Arg Ile Asn Ile Tyr Glu Val Met Lys Pro Pro Ala Glu Val Val Pro 
            180                 185                 190         


Gly His Leu Ile Thr Arg Leu Leu Asp Thr Arg Leu Val His His Asn 
        195                 200                 205             


Val Thr Arg Trp Glu Thr Phe Asp Val Ser Pro Ala Val Leu Arg Trp 
    210                 215                 220                 


Thr Arg Glu Lys Gln Pro Asn Tyr Gly Leu Ala Ile Glu Val Thr His 
225                 230                 235                 240 


Leu His Gln Thr Arg Thr His Gln Gly Gln His Val Arg Ile Ser Arg 
                245                 250                 255     


Ser Leu Pro Gln Gly Ser Gly Asn Trp Ala Gln Leu Arg Pro Leu Leu 
            260                 265                 270         


Val Thr Phe Gly His Asp Gly Arg Gly His Ala Leu Thr Arg Arg Arg 
        275                 280                 285             


Arg Ala Lys Arg Ser Pro Lys His His Ser Gln Arg Ala Arg Lys Lys 
    290                 295                 300                 


Asn Lys Asn Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val 
305                 310                 315                 320 


Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr 
                325                 330                 335     


Cys His Gly Asp Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr 
            340                 345                 350         


Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Ser Ile 
        355                 360                 365             


Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
    370                 375                 380                 


Tyr Leu Asp Glu Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln Glu Met 
385                 390                 395                 400 


Val Val Glu Gly Cys Gly Cys Arg 
                405             


<210> 12
<211> 472
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Gly Ala Ser Arg Leu Leu Phe Leu Trp Leu Gly Cys Phe Cys 
1               5                   10                  15      


Val Ser Leu Ala Gln Gly Glu Arg Pro Lys Pro Pro Phe Pro Glu Leu 
            20                  25                  30          


Arg Lys Ala Val Pro Gly Asp Arg Thr Ala Gly Gly Gly Pro Asp Ser 
        35                  40                  45              


Glu Leu Gln Pro Gln Asp Lys Val Ser Glu His Met Leu Arg Leu Tyr 
    50                  55                  60                  


Asp Arg Tyr Ser Thr Val Gln Ala Ala Arg Thr Pro Gly Ser Leu Glu 
65                  70                  75                  80  


Gly Gly Ser Gln Pro Trp Arg Pro Arg Leu Leu Arg Glu Gly Asn Thr 
                85                  90                  95      


Val Arg Ser Phe Arg Ala Ala Ala Ala Glu Thr Leu Glu Arg Lys Gly 
            100                 105                 110         


Leu Tyr Ile Phe Asn Leu Thr Ser Leu Thr Lys Ser Glu Asn Ile Leu 
        115                 120                 125             


Ser Ala Thr Leu Tyr Phe Cys Ile Gly Glu Leu Gly Asn Ile Ser Leu 
    130                 135                 140                 


Ser Cys Pro Val Ser Gly Gly Cys Ser His His Ala Gln Arg Lys His 
145                 150                 155                 160 


Ile Gln Ile Asp Leu Ser Ala Trp Thr Leu Lys Phe Ser Arg Asn Gln 
                165                 170                 175     


Ser Gln Leu Leu Gly His Leu Ser Val Asp Met Ala Lys Ser His Arg 
            180                 185                 190         


Asp Ile Met Ser Trp Leu Ser Lys Asp Ile Thr Gln Phe Leu Arg Lys 
        195                 200                 205             


Ala Lys Glu Asn Glu Glu Phe Leu Ile Gly Phe Asn Ile Thr Ser Lys 
    210                 215                 220                 


Gly Arg Gln Leu Pro Lys Arg Arg Leu Pro Phe Pro Glu Pro Tyr Ile 
225                 230                 235                 240 


Leu Val Tyr Ala Asn Asp Ala Ala Ile Ser Glu Pro Glu Ser Val Val 
                245                 250                 255     


Ser Ser Leu Gln Gly His Arg Asn Phe Pro Thr Gly Thr Val Pro Lys 
            260                 265                 270         


Trp Asp Ser His Ile Arg Ala Ala Leu Ser Ile Glu Arg Arg Lys Lys 
        275                 280                 285             


Arg Ser Thr Gly Val Leu Leu Pro Leu Gln Asn Asn Glu Leu Pro Gly 
    290                 295                 300                 


Ala Glu Tyr Gln Tyr Lys Lys Asp Glu Val Trp Glu Glu Arg Lys Pro 
305                 310                 315                 320 


Tyr Lys Thr Leu Gln Ala Gln Ala Pro Glu Lys Ser Lys Asn Lys Lys 
                325                 330                 335     


Lys Gln Arg Lys Gly Pro His Arg Lys Ser Gln Thr Leu Gln Phe Asp 
            340                 345                 350         


Glu Gln Thr Leu Lys Lys Ala Arg Arg Lys Gln Trp Ile Glu Pro Arg 
        355                 360                 365             


Asn Cys Ala Arg Arg Tyr Leu Lys Val Asp Phe Ala Asp Ile Gly Trp 
    370                 375                 380                 


Ser Glu Trp Ile Ile Ser Pro Lys Ser Phe Asp Ala Tyr Tyr Cys Ser 
385                 390                 395                 400 


Gly Ala Cys Gln Phe Pro Met Pro Lys Ser Leu Lys Pro Ser Asn His 
                405                 410                 415     


Ala Thr Ile Gln Ser Ile Val Arg Ala Val Gly Val Val Pro Gly Ile 
            420                 425                 430         


Pro Glu Pro Cys Cys Val Pro Glu Lys Met Ser Ser Leu Ser Ile Leu 
        435                 440                 445             


Phe Phe Asp Glu Asn Lys Asn Val Val Leu Lys Val Tyr Pro Asn Met 
    450                 455                 460                 


Thr Val Glu Ser Cys Ala Cys Arg 
465                 470         


<210> 13
<211> 372
<212> PRT
<213> Homo sapiens

<400> 13
Met Pro Pro Pro Gln Gln Gly Pro Cys Gly His His Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Leu Leu Leu Pro Ser Leu Pro Leu Thr Arg Ala Pro Val Pro 
            20                  25                  30          


Pro Gly Pro Ala Ala Ala Leu Leu Gln Ala Leu Gly Leu Arg Asp Glu 
        35                  40                  45              


Pro Gln Gly Ala Pro Arg Leu Arg Pro Val Pro Pro Val Met Trp Arg 
    50                  55                  60                  


Leu Phe Arg Arg Arg Asp Pro Gln Glu Thr Arg Ser Gly Ser Arg Arg 
65                  70                  75                  80  


Thr Ser Pro Gly Val Thr Leu Gln Pro Cys His Val Glu Glu Leu Gly 
                85                  90                  95      


Val Ala Gly Asn Ile Val Arg His Ile Pro Asp Arg Gly Ala Pro Thr 
            100                 105                 110         


Arg Ala Ser Glu Pro Val Ser Ala Ala Gly His Cys Pro Glu Trp Thr 
        115                 120                 125             


Val Val Phe Asp Leu Ser Ala Val Glu Pro Ala Glu Arg Pro Ser Arg 
    130                 135                 140                 


Ala Arg Leu Glu Leu Arg Phe Ala Ala Ala Ala Ala Ala Ala Pro Glu 
145                 150                 155                 160 


Gly Gly Trp Glu Leu Ser Val Ala Gln Ala Gly Gln Gly Ala Gly Ala 
                165                 170                 175     


Asp Pro Gly Pro Val Leu Leu Arg Gln Leu Val Pro Ala Leu Gly Pro 
            180                 185                 190         


Pro Val Arg Ala Glu Leu Leu Gly Ala Ala Trp Ala Arg Asn Ala Ser 
        195                 200                 205             


Trp Pro Arg Ser Leu Arg Leu Ala Leu Ala Leu Arg Pro Arg Ala Pro 
    210                 215                 220                 


Ala Ala Cys Ala Arg Leu Ala Glu Ala Ser Leu Leu Leu Val Thr Leu 
225                 230                 235                 240 


Asp Pro Arg Leu Cys His Pro Leu Ala Arg Pro Arg Arg Asp Ala Glu 
                245                 250                 255     


Pro Val Leu Gly Gly Gly Pro Gly Gly Ala Cys Arg Ala Arg Arg Leu 
            260                 265                 270         


Tyr Val Ser Phe Arg Glu Val Gly Trp His Arg Trp Val Ile Ala Pro 
        275                 280                 285             


Arg Gly Phe Leu Ala Asn Tyr Cys Gln Gly Gln Cys Ala Leu Pro Val 
    290                 295                 300                 


Ala Leu Ser Gly Ser Gly Gly Pro Pro Ala Leu Asn His Ala Val Leu 
305                 310                 315                 320 


Arg Ala Leu Met His Ala Ala Ala Pro Gly Ala Ala Asp Leu Pro Cys 
                325                 330                 335     


Cys Val Pro Ala Arg Leu Ser Pro Ile Ser Val Leu Phe Phe Asp Asn 
            340                 345                 350         


Ser Asp Asn Val Val Leu Arg Gln Tyr Glu Asp Met Val Val Asp Glu 
        355                 360                 365             


Cys Gly Cys Arg 
    370         


<210> 14
<211> 455
<212> PRT
<213> Drosophila sp.

<400> 14
Met Ser Gly Leu Arg Asn Thr Ser Glu Ala Val Ala Val Leu Ala Ser 
1               5                   10                  15      


Leu Gly Leu Gly Met Val Leu Leu Met Phe Val Ala Thr Thr Pro Pro 
            20                  25                  30          


Ala Val Glu Ala Thr Gln Ser Gly Ile Tyr Ile Asp Asn Gly Lys Asp 
        35                  40                  45              


Gln Thr Ile Met His Arg Val Leu Ser Glu Asp Asp Lys Leu Asp Val 
    50                  55                  60                  


Ser Tyr Glu Ile Leu Glu Phe Leu Gly Ile Ala Glu Arg Pro Thr His 
65                  70                  75                  80  


Leu Ser Ser His Gln Leu Ser Leu Arg Lys Ser Ala Pro Lys Phe Leu 
                85                  90                  95      


Leu Asp Val Tyr His Arg Ile Thr Ala Glu Glu Gly Leu Ser Asp Gln 
            100                 105                 110         


Asp Glu Asp Asp Asp Tyr Glu Arg Gly His Arg Ser Arg Arg Ser Ala 
        115                 120                 125             


Asp Leu Glu Glu Asp Glu Gly Glu Gln Gln Lys Asn Phe Ile Thr Asp 
    130                 135                 140                 


Leu Asp Lys Arg Ala Ile Asp Glu Ser Asp Ile Ile Met Thr Phe Leu 
145                 150                 155                 160 


Asn Lys Arg His His Asn Val Asp Glu Leu Arg His Glu His Gly Arg 
                165                 170                 175     


Arg Leu Trp Phe Asp Val Ser Asn Val Pro Asn Asp Asn Tyr Leu Val 
            180                 185                 190         


Met Ala Glu Leu Arg Ile Tyr Gln Asn Ala Asn Glu Gly Lys Trp Leu 
        195                 200                 205             


Thr Ala Asn Arg Glu Phe Thr Ile Thr Val Tyr Ala Ile Gly Thr Gly 
    210                 215                 220                 


Thr Leu Gly Gln His Thr Met Glu Pro Leu Ser Ser Val Asn Thr Thr 
225                 230                 235                 240 


Gly Asp Tyr Val Gly Trp Leu Glu Leu Asn Val Thr Glu Gly Leu His 
                245                 250                 255     


Glu Trp Leu Val Lys Ser Lys Asp Asn His Gly Ile Tyr Ile Gly Ala 
            260                 265                 270         


His Ala Val Asn Arg Pro Asp Arg Glu Val Lys Leu Asp Asp Ile Gly 
        275                 280                 285             


Leu Ile His Arg Lys Val Asp Asp Glu Phe Gln Pro Phe Met Ile Gly 
    290                 295                 300                 


Phe Phe Arg Gly Pro Glu Leu Ile Lys Ala Thr Ala His Ser Ser His 
305                 310                 315                 320 


His Arg Ser Lys Arg Ser Ala Ser His Pro Arg Lys Arg Lys Lys Ser 
                325                 330                 335     


Val Ser Pro Asn Asn Val Pro Leu Leu Glu Pro Met Glu Ser Thr Arg 
            340                 345                 350         


Ser Cys Gln Met Gln Thr Leu Tyr Ile Asp Phe Lys Asp Leu Gly Trp 
        355                 360                 365             


His Asp Trp Ile Ile Ala Pro Glu Gly Tyr Gly Ala Phe Tyr Cys Ser 
    370                 375                 380                 


Gly Glu Cys Asn Phe Pro Leu Asn Ala His Met Asn Ala Thr Asn His 
385                 390                 395                 400 


Ala Ile Val Gln Thr Leu Val His Leu Leu Glu Pro Lys Lys Val Pro 
                405                 410                 415     


Lys Pro Cys Cys Ala Pro Thr Arg Leu Gly Ala Leu Pro Val Leu Tyr 
            420                 425                 430         


His Leu Asn Asp Glu Asn Val Asn Leu Lys Lys Tyr Arg Asn Met Ile 
        435                 440                 445             


Val Lys Ser Cys Gly Cys His 
    450                 455 


<210> 15
<211> 454
<212> PRT
<213> Homo sapiens

<400> 15
Met His Leu Thr Val Phe Leu Leu Lys Gly Ile Val Gly Phe Leu Trp 
1               5                   10                  15      


Ser Cys Trp Val Leu Val Gly Tyr Ala Lys Gly Gly Leu Gly Asp Asn 
            20                  25                  30          


His Val His Ser Ser Phe Ile Tyr Arg Arg Leu Arg Asn His Glu Arg 
        35                  40                  45              


Arg Glu Ile Gln Arg Glu Ile Leu Ser Ile Leu Gly Leu Pro His Arg 
    50                  55                  60                  


Pro Arg Pro Phe Ser Pro Gly Lys Gln Ala Ser Ser Ala Pro Leu Phe 
65                  70                  75                  80  


Met Leu Asp Leu Tyr Asn Ala Met Thr Asn Glu Glu Asn Pro Glu Glu 
                85                  90                  95      


Ser Glu Tyr Ser Val Arg Ala Ser Leu Ala Glu Glu Thr Arg Gly Ala 
            100                 105                 110         


Arg Lys Gly Tyr Pro Ala Ser Pro Asn Gly Tyr Pro Arg Arg Ile Gln 
        115                 120                 125             


Leu Ser Arg Thr Thr Pro Leu Thr Thr Gln Ser Pro Pro Leu Ala Ser 
    130                 135                 140                 


Leu His Asp Thr Asn Phe Leu Asn Asp Ala Asp Met Val Met Ser Phe 
145                 150                 155                 160 


Val Asn Leu Val Glu Arg Asp Lys Asp Phe Ser His Gln Arg Arg His 
                165                 170                 175     


Tyr Lys Glu Phe Arg Phe Asp Leu Thr Gln Ile Pro His Gly Glu Ala 
            180                 185                 190         


Val Thr Ala Ala Glu Phe Arg Ile Tyr Lys Asp Arg Ser Asn Asn Arg 
        195                 200                 205             


Phe Glu Asn Glu Thr Ile Lys Ile Ser Ile Tyr Gln Ile Ile Lys Glu 
    210                 215                 220                 


Tyr Thr Asn Arg Asp Ala Asp Leu Phe Leu Leu Asp Thr Arg Lys Ala 
225                 230                 235                 240 


Gln Ala Leu Asp Val Gly Trp Leu Val Phe Asp Ile Thr Val Thr Ser 
                245                 250                 255     


Asn His Trp Val Ile Asn Pro Gln Asn Asn Leu Gly Leu Gln Leu Cys 
            260                 265                 270         


Ala Glu Thr Gly Asp Gly Arg Ser Ile Asn Val Lys Ser Ala Gly Leu 
        275                 280                 285             


Val Gly Arg Gln Gly Pro Gln Ser Lys Gln Pro Phe Met Val Ala Phe 
    290                 295                 300                 


Phe Lys Ala Ser Glu Val Leu Leu Arg Ser Val Arg Ala Ala Asn Lys 
305                 310                 315                 320 


Arg Lys Asn Gln Asn Arg Asn Lys Ser Ser Ser His Gln Asp Ser Ser 
                325                 330                 335     


Arg Met Ser Ser Val Gly Asp Tyr Asn Thr Ser Glu Gln Lys Gln Ala 
            340                 345                 350         


Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg Asp Leu Gly Trp Gln 
        355                 360                 365             


Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala Phe Tyr Cys Asp Gly 
    370                 375                 380                 


Glu Cys Ser Phe Pro Leu Asn Ala His Met Asn Ala Thr Asn His Ala 
385                 390                 395                 400 


Ile Val Gln Thr Leu Val His Leu Met Phe Pro Asp His Val Pro Lys 
                405                 410                 415     


Pro Cys Cys Ala Pro Thr Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe 
            420                 425                 430         


Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val 
        435                 440                 445             


Arg Ser Cys Gly Cys His 
    450                 


<210> 16
<211> 513
<212> PRT
<213> Homo sapiens

<400> 16
Met Pro Gly Leu Gly Arg Arg Ala Gln Trp Leu Cys Trp Trp Trp Gly 
1               5                   10                  15      


Leu Leu Cys Ser Cys Cys Gly Pro Pro Pro Leu Arg Pro Pro Leu Pro 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Leu Leu Gly Asp Gly Gly 
        35                  40                  45              


Ser Pro Gly Arg Thr Glu Gln Pro Pro Pro Ser Pro Gln Ser Ser Ser 
    50                  55                  60                  


Gly Phe Leu Tyr Arg Arg Leu Lys Thr Gln Glu Lys Arg Glu Met Gln 
65                  70                  75                  80  


Lys Glu Ile Leu Ser Val Leu Gly Leu Pro His Arg Pro Arg Pro Leu 
                85                  90                  95      


His Gly Leu Gln Gln Pro Gln Pro Pro Ala Leu Arg Gln Gln Glu Glu 
            100                 105                 110         


Gln Gln Gln Gln Gln Gln Leu Pro Arg Gly Glu Pro Pro Pro Gly Arg 
        115                 120                 125             


Leu Lys Ser Ala Pro Leu Phe Met Leu Asp Leu Tyr Asn Ala Leu Ser 
    130                 135                 140                 


Ala Asp Asn Asp Glu Asp Gly Ala Ser Glu Gly Glu Arg Gln Gln Ser 
145                 150                 155                 160 


Trp Pro His Glu Ala Ala Ser Ser Ser Gln Arg Arg Gln Pro Pro Pro 
                165                 170                 175     


Gly Ala Ala His Pro Leu Asn Arg Lys Ser Leu Leu Ala Pro Gly Ser 
            180                 185                 190         


Gly Ser Gly Gly Ala Ser Pro Leu Thr Ser Ala Gln Asp Ser Ala Phe 
        195                 200                 205             


Leu Asn Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu Tyr 
    210                 215                 220                 


Asp Lys Glu Phe Ser Pro Arg Gln Arg His His Lys Glu Phe Lys Phe 
225                 230                 235                 240 


Asn Leu Ser Gln Ile Pro Glu Gly Glu Val Val Thr Ala Ala Glu Phe 
                245                 250                 255     


Arg Ile Tyr Lys Asp Cys Val Met Gly Ser Phe Lys Asn Gln Thr Phe 
            260                 265                 270         


Leu Ile Ser Ile Tyr Gln Val Leu Gln Glu His Gln His Arg Asp Ser 
        275                 280                 285             


Asp Leu Phe Leu Leu Asp Thr Arg Val Val Trp Ala Ser Glu Glu Gly 
    290                 295                 300                 


Trp Leu Glu Phe Asp Ile Thr Ala Thr Ser Asn Leu Trp Val Val Thr 
305                 310                 315                 320 


Pro Gln His Asn Met Gly Leu Gln Leu Ser Val Val Thr Arg Asp Gly 
                325                 330                 335     


Val His Val His Pro Arg Ala Ala Gly Leu Val Gly Arg Asp Gly Pro 
            340                 345                 350         


Tyr Asp Lys Gln Pro Phe Met Val Ala Phe Phe Lys Val Ser Glu Val 
        355                 360                 365             


His Val Arg Thr Thr Arg Ser Ala Ser Ser Arg Arg Arg Gln Gln Ser 
    370                 375                 380                 


Arg Asn Arg Ser Thr Gln Ser Gln Asp Val Ala Arg Val Ser Ser Ala 
385                 390                 395                 400 


Ser Asp Tyr Asn Ser Ser Glu Leu Lys Thr Ala Cys Arg Lys His Glu 
                405                 410                 415     


Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala 
            420                 425                 430         


Pro Lys Gly Tyr Ala Ala Asn Tyr Cys Asp Gly Glu Cys Ser Phe Pro 
        435                 440                 445             


Leu Asn Ala His Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu 
    450                 455                 460                 


Val His Leu Met Asn Pro Glu Tyr Val Pro Lys Pro Cys Cys Ala Pro 
465                 470                 475                 480 


Thr Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Asn Ser Asn 
                485                 490                 495     


Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys 
            500                 505                 510         


His 
    


<210> 17
<211> 1878
<212> DNA
<213> Homo sapiens

<400> 17
gggcgcagcg gggcccgtct gcagcaagtg accgacggcc gggacggccg cctgccccct       60

ctgccacctg gggcggtgcg ggcccggagc ccggagcccg ggtagcgcgt agagccggcg      120

cgatgcacgt gcgctcactg cgagctgcgg cgccgcacag cttcgtggcg ctctgggcac      180

ccctgttcct gctgcgctcc gccctggccg acttcagcct ggacaacgag gtgcactcga      240

gcttcatcca ccggcgcctc cgcagccagg agcggcggga gatgcagcgc gagatcctct      300

ccattttggg cttgccccac cgcccgcgcc cgcacctcca gggcaagcac aactcggcac      360

ccatgttcat gctggacctg tacaacgcca tggcggtgga ggagggcggc gggcccggcg      420

gccagggctt ctcctacccc tacaaggccg tcttcagtac ccagggcccc cctctggcca      480

gcctgcaaga tagccatttc ctcaccgacg ccgacatggt catgagcttc gtcaacctcg      540

tggaacatga caaggaattc ttccacccac gctaccacca tcgagagttc cggtttgatc      600

tttccaagat cccagaaggg gaagctgtca cggcagccga attccggatc tacaaggact      660

acatccggga acgcttcgac aatgagacgt tccggatcag cgtttatcag gtgctccagg      720

agcacttggg cagggaatcg gatctcttcc tgctcgacag ccgtaccctc tgggcctcgg      780

aggagggctg gctggtgttt gacatcacag ccaccagcaa ccactgggtg gtcaatccgc      840

ggcacaacct gggcctgcag ctctcggtgg agacgctgga tgggcagagc atcaacccca      900

agttggcggg cctgattggg cggcacgggc cccagaacaa gcagcccttc atggtggctt      960

tcttcaaggc cacggaggtc cacttccgca gcatccggtc cacggggagc aaacagcgca     1020

gccagaaccg ctccaagacg cccaagaacc aggaagccct gcggatggcc aacgtggcag     1080

agaacagcag cagcgaccag aggcaggcct gtaagaagca cgagctgtat gtcagcttcc     1140

gagacctggg ctggcaggac tggatcatcg cgcctgaagg ctacgccgcc tactactgtg     1200

agggggagtg tgccttccct ctgaactcct acatgaacgc caccaaccac gccatcgtgc     1260

agacgctggt ccacttcatc aacccggaaa cggtgcccaa gccctgctgt gcgcccacgc     1320

agctcaatgc catctccgtc ctctacttcg atgacagctc caacgtcatc ctgaagaaat     1380

acagaaacat ggtggtccgg gcctgtggct gccactagct cctccgagaa ttcagaccct     1440

ttggggccaa gtttttctgg atcctccatt gctcgccttg gccaggaacc agcagaccaa     1500

ctgccttttg tgagaccttc ccctccctat ccccaacttt aaaggtgtga gagtattagg     1560

aaacatgagc agcatatggc ttttgatcag tttttcagtg gcagcatcca atgaacaaga     1620

tcctacaagc tgtgcaggca aaacctagca ggaaaaaaaa acaacgcata aagaaaaatg     1680

gccgggccag gtcattggct gggaagtctc agccatgcac ggactcgttt ccagaggtaa     1740

ttatgagcgc ctaccagcca ggccacccag ccgtgggagg aagggggcgt ggcaaggggt     1800

gggcacattg gtgtctgtgc gaaaggaaaa ttgacccgga agttcctgta ataaatgtca     1860

caataaaacg aatgaatg                                                   1878


<210> 18
<211> 1872
<212> DNA
<213> Mus sp.

<400> 18
ctgcagcaag tgacctcggg tcgtggaccg ctgccctgcc ccctccgctg ccacctgggg       60

cggcgcgggc ccggtgcccc ggatcgcgcg tagagccggc gcgatgcacg tgcgctcgct      120

gcgcgctgcg gcgccacaca gcttcgtggc gctctgggcg cctctgttct tgctgcgctc      180

cgccctggcc gatttcagcc tggacaacga ggtgcactcc agcttcatcc accggcgcct      240

ccgcagccag gagcggcggg agatgcagcg ggagatcctg tccatcttag ggttgcccca      300

tcgcccgcgc ccgcacctcc agggaaagca taattcggcg cccatgttca tgttggacct      360

gtacaacgcc atggcggtgg aggagagcgg gccggacgga cagggcttct cctaccccta      420

caaggccgtc ttcagtaccc agggcccccc tttagccagc ctgcaggaca gccacttcct      480

cactgacgcc gacatggtca tgagcttcgt caacctagtg gaacatgaca aagaattctt      540

ccaccctcga taccaccatc gggagttccg gtttgatctt tccaagatcc ccgagggcga      600

acgggtgacc gcagccgaat tcaggatcta taaggactac atccgggagc gatttgacaa      660

cgagaccttc cagatcacag tctatcaggt gctccaggag cactcaggca gggagtcgga      720

cctcttcttg ctggacagcc gcaccatctg ggcttctgag gagggctggt tggtgtttga      780

tatcacagcc accagcaacc actgggtggt caaccctcgg cacaacctgg gcttacagct      840

ctctgtggag accctggatg ggcagagcat caaccccaag ttggcaggcc tgattggacg      900

gcatggaccc cagaacaagc aacccttcat ggtggccttc ttcaaggcca cggaagtcca      960

tctccgtagt atccggtcca cggggggcaa gcagcgcagc cagaatcgct ccaagacgcc     1020

aaagaaccaa gaggccctga ggatggccag tgtggcagaa aacagcagca gtgaccagag     1080

gcaggcctgc aagaaacatg agctgtacgt cagcttccga gaccttggct ggcaggactg     1140

gatcattgca cctgaaggct atgctgccta ctactgtgag ggagagtgcg ccttccctct     1200

gaactcctac atgaacgcca ccaaccacgc catcgtccag acactggttc acttcatcaa     1260

cccagacaca gtacccaagc cctgctgtgc gcccacccag ctcaacgcca tctctgtcct     1320

ctacttcgac gacagctcta atgtcatcct gaagaagtac agaaacatgg tggtccgggc     1380

ctgtggctgc cactagctct tcctgagacc ctgacctttg cggggccaca cctttccaaa     1440

tcttcgatgt ctcaccatct aagtctctca ctgcccacct tggcgaggag ccaacagacc     1500

aacctctcct gagccttccc ctcacctccc caaccggaag catgtaaggg ttccagaaac     1560

ctgagcgtgc aggcagctga tgagcgccct ttccttctgg cacgtgacgg acaagatcct     1620

accagctacc acagcaaacg cctaagagca ggaaaaatgt ctgccaggaa agtgtccatt     1680

ggccacatgg cccctggcgc tctgagtctt tgaggagtaa tcgcaagcct cgttcagctg     1740

cagcagaagg aagggcttag ccagggtggg cgctggcgtc tgtgttgaag ggaaaccaag     1800

cagaagccac tgtaatgata tgtcacaata aaacccatga atgaaaaaaa aaaaaaaaaa     1860

aaaaaaaaaa aa                                                         1872


<210> 19
<211> 430
<212> PRT
<213> Mus sp.

<400> 19
Met His Val Arg Ser Leu Arg Ala Ala Ala Pro His Ser Phe Val Ala 
1               5                   10                  15      


Leu Trp Ala Pro Leu Phe Leu Leu Arg Ser Ala Leu Ala Asp Phe Ser 
            20                  25                  30          


Leu Asp Asn Glu Val His Ser Ser Phe Ile His Arg Arg Leu Arg Ser 
        35                  40                  45              


Gln Glu Arg Arg Glu Met Gln Arg Glu Ile Leu Ser Ile Leu Gly Leu 
    50                  55                  60                  


Pro His Arg Pro Arg Pro His Leu Gln Gly Lys His Asn Ser Ala Pro 
65                  70                  75                  80  


Met Phe Met Leu Asp Leu Tyr Asn Ala Met Ala Val Glu Glu Ser Gly 
                85                  90                  95      


Pro Asp Gly Gln Gly Phe Ser Tyr Pro Tyr Lys Ala Val Phe Ser Thr 
            100                 105                 110         


Gln Gly Pro Pro Leu Ala Ser Leu Gln Asp Ser His Phe Leu Thr Asp 
        115                 120                 125             


Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu His Asp Lys Glu 
    130                 135                 140                 


Phe Phe His Pro Arg Tyr His His Arg Glu Phe Arg Phe Asp Leu Ser 
145                 150                 155                 160 


Lys Ile Pro Glu Gly Glu Arg Val Thr Ala Ala Glu Phe Arg Ile Tyr 
                165                 170                 175     


Lys Asp Tyr Ile Arg Glu Arg Phe Asp Asn Glu Thr Phe Gln Ile Thr 
            180                 185                 190         


Val Tyr Gln Val Leu Gln Glu His Ser Gly Arg Glu Ser Asp Leu Phe 
        195                 200                 205             


Leu Leu Asp Ser Arg Thr Ile Trp Ala Ser Glu Glu Gly Trp Leu Val 
    210                 215                 220                 


Phe Asp Ile Thr Ala Thr Ser Asn His Trp Val Val Asn Pro Arg His 
225                 230                 235                 240 


Asn Leu Gly Leu Gln Leu Ser Val Glu Thr Leu Asp Gly Gln Ser Ile 
                245                 250                 255     


Asn Pro Lys Leu Ala Gly Leu Ile Gly Arg His Gly Pro Gln Asn Lys 
            260                 265                 270         


Gln Pro Phe Met Val Ala Phe Phe Lys Ala Thr Glu Val His Leu Arg 
        275                 280                 285             


Ser Ile Arg Ser Thr Gly Gly Lys Gln Arg Ser Gln Asn Arg Ser Lys 
    290                 295                 300                 


Thr Pro Lys Asn Gln Glu Ala Leu Arg Met Ala Ser Val Ala Glu Asn 
305                 310                 315                 320 


Ser Ser Ser Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr Val 
                325                 330                 335     


Ser Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu Gly 
            340                 345                 350         


Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn Ser 
        355                 360                 365             


Tyr Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His Phe 
    370                 375                 380                 


Ile Asn Pro Asp Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln Leu 
385                 390                 395                 400 


Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile Leu 
                405                 410                 415     


Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
            420                 425                 430 


<210> 20
<211> 1842
<212> DNA
<213> Homo sapiens

<400> 20
ccacagtggc gccggcagag caggagtggc tggaggagct gtggttggag caggaggtgg       60

cacggcaggg ctggagggct ccctatgagt ggcggagacg gcccaggagg cgctggagca      120

acagctccca caccgcacca agcggtggct gcaggagctc gcccatcgcc cctgcgctgc      180

tcggaccgcg gccacagccg gactggcggg tacggcggcg acagacggat tggccgagag      240

tcccagtccg cagagtagcc ccggcctcga ggcggtggcg tcccggtcct ctccgtccag      300

gagccaggac aggtgtcgcg cggcggggct ccagggaccg cgcctgaggc cggctgcccg      360

cccgtcccgc cccgccccgc cgcccgccgc ccgccgagcc cagcctcctt gccgtcgggg      420

cgtccccagg ccctgggtcg gccgcggagc cgatgcgcgc ccgctgagcg ccccagctga      480

gcgcccccgg cctgccatga ccgcgctccc cggcccgctc tggctcctgg gcctggcgct      540

atgcgcgctg ggcgggggcg gccccggcct gcgacccccg cccggctgtc cccagcgacg      600

tctgggcgcg cgcgagcgcc gggacgtgca gcgcgagatc ctggcggtgc tcgggctgcc      660

tgggcggccc cggccccgcg cgccacccgc cgcctcccgg ctgcccgcgt ccgcgccgct      720

cttcatgctg gacctgtacc acgccatggc cggcgacgac gacgaggacg gcgcgcccgc      780

ggagcggcgc ctgggccgcg ccgacctggt catgagcttc gttaacatgg tggagcgaga      840

ccgtgccctg ggccaccagg agccccattg gaaggagttc cgctttgacc tgacccagat      900

cccggctggg gaggcggtca cagctgcgga gttccggatt tacaaggtgc ccagcatcca      960

cctgctcaac aggaccctcc acgtcagcat gttccaggtg gtccaggagc agtccaacag     1020

ggagtctgac ttgttctttt tggatcttca gacgctccga gctggagacg agggctggct     1080

ggtgctggat gtcacagcag ccagtgactg ctggttgctg aagcgtcaca aggacctggg     1140

actccgcctc tatgtggaga ctgaggacgg gcacagcgtg gatcctggcc tggccggcct     1200

gctgggtcaa cgggccccac gctcccaaca gcctttcgtg gtcactttct tcagggccag     1260

tccgagtccc atccgcaccc ctcgggcagt gaggccactg aggaggaggc agccgaagaa     1320

aagcaacgag ctgccgcagg ccaaccgact cccagggatc tttgatgacg tccacggctc     1380

ccacggccgg caggtctgcc gtcggcacga gctctacgtc agcttccagg acctcggctg     1440

gctggactgg gtcatcgctc cccaaggcta ctcggcctat tactgtgagg gggagtgctc     1500

cttcccactg gactcctgca tgaatgccac caaccacgcc atcctgcagt ccctggtgca     1560

cctgatgaag ccaaacgcag tccccaaggc gtgctgtgca cccaccaagc tgagcgccac     1620

ctctgtgctc tactatgaca gcagcaacaa cgtcatcctg cgcaagcacc gcaacatggt     1680

ggtcaaggcc tgcggctgcc actgagtcag cccgcccagc cctactgcag ccacccttct     1740

catctggatc gggccctgca gaggcagaaa acccttaaat gctgtcacag ctcaagcagg     1800

agtgtcaggg gccctcactc tctgtgccta cttcctgtca gg                        1842


<210> 21
<211> 402
<212> PRT
<213> Homo sapiens

<400> 21
Met Thr Ala Leu Pro Gly Pro Leu Trp Leu Leu Gly Leu Ala Leu Cys 
1               5                   10                  15      


Ala Leu Gly Gly Gly Gly Pro Gly Leu Arg Pro Pro Pro Gly Cys Pro 
            20                  25                  30          


Gln Arg Arg Leu Gly Ala Arg Glu Arg Arg Asp Val Gln Arg Glu Ile 
        35                  40                  45              


Leu Ala Val Leu Gly Leu Pro Gly Arg Pro Arg Pro Arg Ala Pro Pro 
    50                  55                  60                  


Ala Ala Ser Arg Leu Pro Ala Ser Ala Pro Leu Phe Met Leu Asp Leu 
65                  70                  75                  80  


Tyr His Ala Met Ala Gly Asp Asp Asp Glu Asp Gly Ala Pro Ala Glu 
                85                  90                  95      


Arg Arg Leu Gly Arg Ala Asp Leu Val Met Ser Phe Val Asn Met Val 
            100                 105                 110         


Glu Arg Asp Arg Ala Leu Gly His Gln Glu Pro His Trp Lys Glu Phe 
        115                 120                 125             


Arg Phe Asp Leu Thr Gln Ile Pro Ala Gly Glu Ala Val Thr Ala Ala 
    130                 135                 140                 


Glu Phe Arg Ile Tyr Lys Val Pro Ser Ile His Leu Leu Asn Arg Thr 
145                 150                 155                 160 


Leu His Val Ser Met Phe Gln Val Val Gln Glu Gln Ser Asn Arg Glu 
                165                 170                 175     


Ser Asp Leu Phe Phe Leu Asp Leu Gln Thr Leu Arg Ala Gly Asp Glu 
            180                 185                 190         


Gly Trp Leu Val Leu Asp Val Thr Ala Ala Ser Asp Cys Trp Leu Leu 
        195                 200                 205             


Lys Arg His Lys Asp Leu Gly Leu Arg Leu Tyr Val Glu Thr Glu Asp 
    210                 215                 220                 


Gly His Ser Val Asp Pro Gly Leu Ala Gly Leu Leu Gly Gln Arg Ala 
225                 230                 235                 240 


Pro Arg Ser Gln Gln Pro Phe Val Val Thr Phe Phe Arg Ala Ser Pro 
                245                 250                 255     


Ser Pro Ile Arg Thr Pro Arg Ala Val Arg Pro Leu Arg Arg Arg Gln 
            260                 265                 270         


Pro Lys Lys Ser Asn Glu Leu Pro Gln Ala Asn Arg Leu Pro Gly Ile 
        275                 280                 285             


Phe Asp Asp Val His Gly Ser His Gly Arg Gln Val Cys Arg Arg His 
    290                 295                 300                 


Glu Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Leu Asp Trp Val Ile 
305                 310                 315                 320 


Ala Pro Gln Gly Tyr Ser Ala Tyr Tyr Cys Glu Gly Glu Cys Ser Phe 
                325                 330                 335     


Pro Leu Asp Ser Cys Met Asn Ala Thr Asn His Ala Ile Leu Gln Ser 
            340                 345                 350         


Leu Val His Leu Met Lys Pro Asn Ala Val Pro Lys Ala Cys Cys Ala 
        355                 360                 365             


Pro Thr Lys Leu Ser Ala Thr Ser Val Leu Tyr Tyr Asp Ser Ser Asn 
    370                 375                 380                 


Asn Val Ile Leu Arg Lys His Arg Asn Met Val Val Lys Ala Cys Gly 
385                 390                 395                 400 


Cys His 
        


<210> 22
<211> 1917
<212> DNA
<213> Mus sp.

<400> 22
gccaggcaca ggtgcgccgt ctggtcctcc ccgtctggcg tcagccgagc ccgaccagct       60

accagtggat gcgcgccggc tgaaagtccg agatggctat gcgtcccggg ccactctggc      120

tattgggcct tgctctgtgc gcgctgggag gcggccacgg tccgcgtccc ccgcacacct      180

gtccccagcg tcgcctggga gcgcgcgagc gccgcgacat gcagcgtgaa atcctggcgg      240

tgctcgggct accgggacgg ccccgacccc gtgcacaacc cgccgctgcc cggcagccag      300

cgtccgcgcc cctcttcatg ttggacctat accacgccat gaccgatgac gacgacggcg      360

ggccaccaca ggctcactta ggccgtgccg acctggtcat gagcttcgtc aacatggtgg      420

aacgcgaccg taccctgggc taccaggagc cacactggaa ggaattccac tttgacctaa      480

cccagatccc tgctggggag gctgtcacag ctgctgagtt ccggatctac aaagaaccca      540

gcacccaccc gctcaacaca accctccaca tcagcatgtt cgaagtggtc caagagcact      600

ccaacaggga gtctgacttg ttctttttgg atcttcagac gctccgatct ggggacgagg      660

gctggctggt gctggacatc acagcagcca gtgaccgatg gctgctgaac catcacaagg      720

acctgggact ccgcctctat gtggaaaccg cggatgggca cagcatggat cctggcctgg      780

ctggtctgct tggacgacaa gcaccacgct ccagacagcc tttcatggta accttcttca      840

gggccagcca gagtcctgtg cgggcccctc gggcagcgag accactgaag aggaggcagc      900

caaagaaaac gaacgagctt ccgcacccca acaaactccc agggatcttt gatgatggcc      960

acggttcccg cggcagagag gtttgccgca ggcatgagct ctacgtcagc ttccgtgacc     1020

ttggctggct ggactgggtc atcgcccccc agggctactc tgcctattac tgtgaggggg     1080

agtgtgcttt cccactggac tcctgtatga acgccaccaa ccatgccatc ttgcagtctc     1140

tggtgcacct gatgaagcca gatgttgtcc ccaaggcatg ctgtgcaccc accaaactga     1200

gtgccacctc tgtgctgtac tatgacagca gcaacaatgt catcctgcgt aaacaccgta     1260

acatggtggt caaggcctgt ggctgccact gaggccccgc ccagcatcct gcttctacta     1320

ccttaccatc tggccgggcc cctctccaga ggcagaaacc cttctatgtt atcatagctc     1380

agacaggggc aatgggaggc ccttcacttc ccctggccac ttcctgctaa aattctggtc     1440

tttcccagtt cctctgtcct tcatggggtt tcggggctat caccccgccc tctccatcct     1500

cctaccccaa gcatagactg aatgcacaca gcatcccaga gctatgctaa ctgagaggtc     1560

tggggtcagc actgaaggcc cacatgagga agactgatcc ttggccatcc tcagcccaca     1620

atggcaaatt ctggatggtc taagaagccc tggaattcta aactagatga tctgggctct     1680

ctgcaccatt cattgtggca gttgggacat ttttaggtat aacagacaca tacacttaga     1740

tcaatgcatc gctgtactcc ttgaaatcag agctagcttg ttagaaaaag aatcagagcc     1800

aggtatagcg gtgcatgtca ttaatcccag cgctaaagag acagagacag gagaatctct     1860

gtgagttcaa ggccacatag aaagagcctg tctcgggagc aggaaaaaaa aaaaaaa        1917


<210> 23
<211> 399
<212> PRT
<213> Mus sp.

<400> 23
Met Ala Met Arg Pro Gly Pro Leu Trp Leu Leu Gly Leu Ala Leu Cys 
1               5                   10                  15      


Ala Leu Gly Gly Gly His Gly Pro Arg Pro Pro His Thr Cys Pro Gln 
            20                  25                  30          


Arg Arg Leu Gly Ala Arg Glu Arg Arg Asp Met Gln Arg Glu Ile Leu 
        35                  40                  45              


Ala Val Leu Gly Leu Pro Gly Arg Pro Arg Pro Arg Ala Gln Pro Ala 
    50                  55                  60                  


Ala Ala Arg Gln Pro Ala Ser Ala Pro Leu Phe Met Leu Asp Leu Tyr 
65                  70                  75                  80  


His Ala Met Thr Asp Asp Asp Asp Gly Gly Pro Pro Gln Ala His Leu 
                85                  90                  95      


Gly Arg Ala Asp Leu Val Met Ser Phe Val Asn Met Val Glu Arg Asp 
            100                 105                 110         


Arg Thr Leu Gly Tyr Gln Glu Pro His Trp Lys Glu Phe His Phe Asp 
        115                 120                 125             


Leu Thr Gln Ile Pro Ala Gly Glu Ala Val Thr Ala Ala Glu Phe Arg 
    130                 135                 140                 


Ile Tyr Lys Glu Pro Ser Thr His Pro Leu Asn Thr Thr Leu His Ile 
145                 150                 155                 160 


Ser Met Phe Glu Val Val Gln Glu His Ser Asn Arg Glu Ser Asp Leu 
                165                 170                 175     


Phe Phe Leu Asp Leu Gln Thr Leu Arg Ser Gly Asp Glu Gly Trp Leu 
            180                 185                 190         


Val Leu Asp Ile Thr Ala Ala Ser Asp Arg Trp Leu Leu Asn His His 
        195                 200                 205             


Lys Asp Leu Gly Leu Arg Leu Tyr Val Glu Thr Ala Asp Gly His Ser 
    210                 215                 220                 


Met Asp Pro Gly Leu Ala Gly Leu Leu Gly Arg Gln Ala Pro Arg Ser 
225                 230                 235                 240 


Arg Gln Pro Phe Met Val Thr Phe Phe Arg Ala Ser Gln Ser Pro Val 
                245                 250                 255     


Arg Ala Pro Arg Ala Ala Arg Pro Leu Lys Arg Arg Gln Pro Lys Lys 
            260                 265                 270         


Thr Asn Glu Leu Pro His Pro Asn Lys Leu Pro Gly Ile Phe Asp Asp 
        275                 280                 285             


Gly His Gly Ser Arg Gly Arg Glu Val Cys Arg Arg His Glu Leu Tyr 
    290                 295                 300                 


Val Ser Phe Arg Asp Leu Gly Trp Leu Asp Trp Val Ile Ala Pro Gln 
305                 310                 315                 320 


Gly Tyr Ser Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asp 
                325                 330                 335     


Ser Cys Met Asn Ala Thr Asn His Ala Ile Leu Gln Ser Leu Val His 
            340                 345                 350         


Leu Met Lys Pro Asp Val Val Pro Lys Ala Cys Cys Ala Pro Thr Lys 
        355                 360                 365             


Leu Ser Ala Thr Ser Val Leu Tyr Tyr Asp Ser Ser Asn Asn Val Ile 
    370                 375                 380                 


Leu Arg Lys His Arg Asn Met Val Val Lys Ala Cys Gly Cys His 
385                 390                 395                 


<210> 24
<211> 97
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (6)..(6)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (6)..(6)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (8)..(8)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (18)..(18)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (18)..(18)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (23)..(23)
<223> /replace="Asn" or "Phe"

<220>
<221> misc_feature
<222> (23)..(23)
<223> /note="Residue given in the sequence has no preference
      with respect to those in the annotation for said
      position"

<220>
<221> VARIANT
<222> (26)..(26)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (26)..(26)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (30)..(30)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (30)..(30)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (31)..(31)
<223> /replace="Leu" or "Tyr"

<220>
<221> misc_feature
<222> (31)..(31)
<223> /note="Residue given in the sequence has no preference
      with respect to those in the annotation for said
      position"

<220>
<221> VARIANT
<222> (33)..(33)
<223> /replace="Val" or "Met"

<220>
<221> misc_feature
<222> (33)..(33)
<223> /note="Residue given in the sequence has no preference
      with respect to those in the annotation for said
      position"

<220>
<221> VARIANT
<222> (34)..(34)
<223> /replace="Asp" or "Ala" or "Thr" or "Pro"

<220>
<221> misc_feature
<222> (34)..(34)
<223> /note="Residue given in the sequence has no preference
      with respect to those in the annotation for said
      position"

<220>
<221> VARIANT
<222> (35)..(35)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (35)..(35)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="His"

<220>
<221> misc_feature
<222> (36)..(36)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (51)..(51)
<223> /replace="Leu" or "Val"

<220>
<221> misc_feature
<222> (51)..(51)
<223> /note="Residue given in the sequence has no preference
      with respect to those in the annotation for said
      position"

<220>
<221> VARIANT
<222> (52)..(52)
<223> /replace="Met"

<220>
<221> misc_feature
<222> (52)..(52)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (53)..(53)
<223> /replace="Phe"

<220>
<221> misc_feature
<222> (53)..(53)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (55)..(55)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (55)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> MOD_RES
<222> (56)..(56)
<223> Any amino acid

<220>
<221> VARIANT
<222> (66)..(66)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (66)..(66)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (67)..(67)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (67)..(67)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> MOD_RES
<222> (78)..(78)
<223> Any amino acid

<220>
<221> VARIANT
<222> (88)..(88)
<223> /replace="Trp"

<220>
<221> misc_feature
<222> (88)..(88)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (90)..(90)
<223> /replace="Thr" or "Ala" or "Ile"

<220>
<221> misc_feature
<222> (90)..(90)
<223> /note="Residue given in the sequence has no preference
      with respect to those in the annotation for said
      position"

<220>
<221> VARIANT
<222> (92)..(92)
<223> /replace="Lys" or "Val" or "Asp" or "Gln" or "Glu"

<220>
<221> misc_feature
<222> (92)..(92)
<223> /note="Residue given in the sequence has no preference
      with respect to those in the annotation for said
      position"

<220>
<221> VARIANT
<222> (93)..(93)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (93)..(93)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<400> 24
Leu Tyr Val Ser Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala 
1               5                   10                  15      


Pro Glu Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro 
            20                  25                  30          


Leu Asn Ser Tyr Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu 
        35                  40                  45              


Val His Phe Ile Asn Pro Glu Xaa Val Pro Lys Pro Cys Cys Ala Pro 
    50                  55                  60                  


Thr Gln Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Xaa Ser Asn 
65                  70                  75                  80  


Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys 
                85                  90                  95      


His 
    


<210> 25
<211> 101
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (2)..(2)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (3)..(3)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (11)..(11)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (11)..(11)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (16)..(16)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (16)..(16)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (19)..(19)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (19)..(19)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (23)..(23)
<223> /replace="Gln"

<220>
<221> misc_feature
<222> (23)..(23)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (26)..(26)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (26)..(26)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (35)..(35)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (35)..(35)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (39)..(39)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (39)..(39)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (41)..(41)
<223> /replace="Cys"

<220>
<221> misc_feature
<222> (41)..(41)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (50)..(50)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (50)..(50)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (52)..(52)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (52)..(52)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (56)..(56)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (56)..(56)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (57)..(57)
<223> /replace="Met"

<220>
<221> misc_feature
<222> (57)..(57)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (58)..(58)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (58)..(58)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (60)..(60)
<223> /replace="Asp" or "Asn"

<220>
<221> misc_feature
<222> (60)..(60)
<223> /note="Residue given in the sequence has no preference
      with respect to those in the annotation for said
      position"

<220>
<221> VARIANT
<222> (61)..(61)
<223> /replace="Ala" or "Val"

<220>
<221> misc_feature
<222> (61)..(61)
<223> /note="Residue given in the sequence has no preference
      with respect to those in the annotation for said
      position"

<220>
<221> VARIANT
<222> (65)..(65)
<223> /replace="Ala"

<220>
<221> misc_feature
<222> (65)..(65)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (71)..(71)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (71)..(71)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (73)..(73)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (73)..(73)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (75)..(75)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (75)..(75)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (80)..(80)
<223> /replace="Tyr"

<220>
<221> misc_feature
<222> (80)..(80)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (82)..(82)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (82)..(82)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (84)..(84)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (84)..(84)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (89)..(89)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (89)..(89)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> VARIANT
<222> (91)..(91)
<223> /replace="His"

<220>
<221> misc_feature
<222> (91)..(91)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<220>
<221> MOD_RES
<222> (96)..(96)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (96)..(96)
<223> /note="Residue given in the sequence has no preference
      with respect to the residue in the annotation for said
      position"

<400> 25
Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg Asp Leu Gly Trp Gln 
1               5                   10                  15      


Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly 
            20                  25                  30          


Glu Cys Ala Phe Pro Leu Asn Ser Tyr Met Asn Ala Thr Asn His Ala 
        35                  40                  45              


Ile Val Gln Ser Leu Val His Phe Ile Asn Pro Glu Thr Val Pro Lys 
    50                  55                  60                  


Pro Cys Cys Ala Pro Thr Gln Leu Asn Ala Ile Ser Val Leu Tyr Phe
65                  70                  75                  80  


Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr Arg Asn Met Val Arg 
                85                  90                  95      


Ala Cys Gly Cys His 
            100     


<210> 26
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 26
gagaggtcca ttccaactgc tcagatgaag                                        30


<210> 27
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 27
gtcttcactt cgagtctgat ccggagaaag                                        30


<210> 28
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 28
agcatgtcct ctgctcactt caacc                                             25


<210> 29
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 29
cgtccatgaa gttgttgccg at                                                22


<210> 30
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 30
tgggtggtga tccactggat c                                                 21


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 31
ttgccttgag tcagtgcgcc                                                   20


<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 32
agcccagcca agcactgtca                                                   20


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 33
gagcatcgtc cccagcaaag                                                   20


<210> 34
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 34
gaagatcgtc gacatgtaca aggg                                              24


<210> 35
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 35
tgcatagaat ggactggtcc tcc                                               23


<210> 36
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 36
gctacacaag accctgagac tgacc                                             25


<210> 37
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 37
tctccatctc tgctgagggg at                                                22


<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 38
cacgacaacc gcaccatggt                                                   20


<210> 39
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 39
tgacagtaac cacagtccca tctg                                              24


<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 40
gctggtgaag cccttcgaga                                                   20


<210> 41
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 41
atgtggtaaa gggcgtgcg                                                    19


<210> 42
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 42
agttcatggc tccagtcccc                                                   20


<210> 43
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 43
tggaggctga aaggtcactg c                                                 21


<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 44
agccaacact gtgcgcagct                                                   20


<210> 45
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 45
cctgaagctc tgctgaggtg ataa                                              24


<210> 46
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 46
atgagagccc tcacactcct c                                                 21


<210> 47
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 47
gccgtagaag cgccgatagg c                                                 21


<210> 48
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 48
tcctgttcga cagtcagccg                                                   20


<210> 49
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 49
tggtgaccag gcgcccaata                                                   20


<210> 50
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 50
tcccttctca agcaccaatg gact                                              24


<210> 51
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 51
agctgtgaat gggcttcttc ctca                                              24


<210> 52
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 52
tgttccagta tgactccact cacg                                              24


<210> 53
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 53
gaagacacca gtagactcca cgaca                                             25


<210> 54
<211> 102
<212> PRT
<213> Homo sapiens

<400> 54
Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg Asp Leu Gly Trp Gln 
1               5                   10                  15      


Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly 
            20                  25                  30          


Glu Cys Ala Phe Pro Leu Asn Ser Tyr Met Asn Ala Thr Asn His Ala 
        35                  40                  45              


Ile Val Gln Thr Leu Val His Phe Ile Asn Pro Glu Thr Val Pro Lys 
    50                  55                  60                  


Pro Cys Cys Ala Pro Thr Gln Leu Asn Ala Ile Ser Val Leu Tyr Phe 
65                  70                  75                  80  


Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val 
                85                  90                  95      


Arg Ala Cys Gly Cys His 
            100         


<210> 55
<211> 102
<212> PRT
<213> Mus sp.

<400> 55
Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg Asp Leu Gly Trp Gln 
1               5                   10                  15      


Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly 
            20                  25                  30          


Glu Cys Ala Phe Pro Leu Asn Ser Tyr Met Asn Ala Thr Asn His Ala 
        35                  40                  45              


Ile Val Gln Thr Leu Val His Phe Ile Asn Pro Asp Thr Val Pro Lys 
    50                  55                  60                  


Pro Cys Cys Ala Pro Thr Gln Leu Asn Ala Ile Ser Val Leu Tyr Phe 
65                  70                  75                  80  


Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val 
                85                  90                  95      


Arg Ala Cys Gly Cys His 
            100         


<210> 56
<211> 102
<212> PRT
<213> Homo sapiens

<400> 56
Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg Asp Leu Gly Trp Gln 
1               5                   10                  15      


Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala Phe Tyr Cys Asp Gly 
            20                  25                  30          


Glu Cys Ser Phe Pro Leu Asn Ala His Met Asn Ala Thr Asn His Ala 
        35                  40                  45              


Ile Val Gln Thr Leu Val His Leu Met Phe Pro Asp His Val Pro Lys 
    50                  55                  60                  


Pro Cys Cys Ala Pro Thr Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe 
65                  70                  75                  80  


Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val 
                85                  90                  95      


Arg Ser Cys Gly Cys His 
            100         


<210> 57
<211> 102
<212> PRT
<213> Homo sapiens

<400> 57
Cys Arg Lys His Glu Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Gln 
1               5                   10                  15      


Asp Trp Ile Ile Ala Pro Lys Gly Tyr Ala Ala Asn Tyr Cys Asp Gly 
            20                  25                  30          


Glu Cys Ser Phe Pro Leu Asn Ala His Met Asn Ala Thr Asn His Ala 
        35                  40                  45              


Ile Val Gln Thr Leu Val His Leu Met Asn Pro Glu Tyr Val Pro Lys 
    50                  55                  60                  


Pro Cys Cys Ala Pro Thr Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe 
65                  70                  75                  80  


Asp Asp Asn Ser Asn Val Ile Leu Lys Lys Tyr Arg Trp Met Val Val 
                85                  90                  95      


Arg Ala Cys Gly Cys His 
            100         


<210> 58
<211> 102
<212> PRT
<213> Mus sp.

<400> 58
Cys Lys Lys His Gly Leu Tyr Val Ser Phe Gln Asp Val Gly Trp Gln 
1               5                   10                  15      


Asp Trp Ile Ile Ala Pro Lys Gly Tyr Ala Ala Asn Tyr Cys Asp Gly 
            20                  25                  30          


Glu Cys Ser Phe Pro Leu Asn Ala His Met Asn Ala Thr Asn His Ala 
        35                  40                  45              


Ile Val Gln Thr Leu Val His Val Met Asn Pro Glu Tyr Val Pro Lys 
    50                  55                  60                  


Pro Cys Cys Ala Pro Thr Lys Val Asn Ala Ile Ser Val Leu Tyr Phe 
65                  70                  75                  80  


Asp Asp Asn Ser Asn Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val 
                85                  90                  95      


Arg Ala Cys Gly Cys His 
            100         


<210> 59
<211> 102
<212> PRT
<213> Homo sapiens

<400> 59
Cys Arg Arg His Glu Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Leu 
1               5                   10                  15      


Asp Trp Val Ile Ala Pro Gln Gly Tyr Ser Ala Tyr Tyr Cys Glu Gly 
            20                  25                  30          


Glu Cys Ser Phe Pro Leu Asp Ser Cys Met Asn Ala Thr Asn His Ala 
        35                  40                  45              


Ile Leu Gln Ser Leu Val His Leu Met Lys Pro Asn Ala Val Pro Lys 
    50                  55                  60                  


Ala Cys Cys Ala Pro Thr Lys Leu Ser Ala Thr Ser Val Leu Tyr Tyr 
65                  70                  75                  80  


Asp Ser Ser Asn Asn Val Ile Leu Arg Lys His Arg Asn Met Val Val 
                85                  90                  95      


Lys Ala Cys Gly Cys His 
            100         


<210> 60
<211> 102
<212> PRT
<213> Mus sp.

<400> 60
Cys Arg Arg His Glu Leu Tyr Val Ser Phe Arg Asp Leu Gly Trp Leu 
1               5                   10                  15      


Asp Trp Val Ile Ala Pro Gln Gly Tyr Ser Ala Tyr Tyr Cys Glu Gly 
            20                  25                  30          


Glu Cys Ala Phe Pro Leu Asp Ser Cys Met Asn Ala Thr Asn His Ala 
        35                  40                  45              


Ile Leu Gln Ser Leu Val His Leu Met Lys Pro Asp Val Val Pro Lys 
    50                  55                  60                  


Ala Cys Cys Ala Pro Thr Lys Leu Ser Ala Thr Ser Val Leu Tyr Tyr 
65                  70                  75                  80  


Asp Ser Ser Asn Asn Val Ile Leu Arg Lys His Arg Asn Met Val Val 
                85                  90                  95      


Lys Ala Cys Gly Cys His 
            100             


<210> 61
<211> 102
<212> PRT
<213> Drosophila sp.

<400> 61
Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asp 
1               5                   10                  15      


Asp Trp Ile Val Ala Pro Leu Gly Tyr Asp Ala Tyr Tyr Cys His Gly 
            20                  25                  30          


Lys Cys Pro Phe Pro Leu Ala Asp His Phe Asn Ser Thr Asn His Ala 
        35                  40                  45              


Val Val Gln Thr Leu Val Asn Asn Asn Asn Pro Gly Lys Val Pro Lys 
    50                  55                  60                  


Ala Cys Cys Val Pro Thr Gln Leu Asn Ser Val Ala Met Leu Tyr Leu 
65                  70                  75                  80  


Asn Asp Gln Ser Thr Val Val Leu Lys Asn Tyr Gln Glu Met Thr Val 
                85                  90                  95      


Val Gly Cys Gly Cys Arg 
            100         


<210> 62
<211> 101
<212> PRT
<213> Homo sapiens

<400> 62
Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn 
1               5                   10                  15      


Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly 
            20                  25                  30          


Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala 
        35                  40                  45              


Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala 
    50                  55                  60                  


Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp 
65                  70                  75                  80  


Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu 
                85                  90                  95      


Gly Cys Gly Cys Arg 
            100         


<210> 63
<211> 101
<212> PRT
<213> Homo sapiens

<400> 63
Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn 
1               5                   10                  15      


Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr Cys His Gly 
            20                  25                  30          


Asp Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala 
        35                  40                  45              


Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Ser Ile Pro Lys Ala 
    50                  55                  60                  


Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp 
65                  70                  75                  80  


Glu Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln Glu Met Val Val Glu 
                85                  90                  95      


Gly Cys Gly Cys Arg 
            100         


<210> 64
<211> 103
<212> PRT
<213> Homo sapiens

<400> 64
Cys Ala Arg Arg Tyr Leu Lys Val Asp Phe Ala Asp Ile Gly Trp Ser 
1               5                   10                  15      


Glu Trp Ile Ile Ser Pro Lys Ser Phe Asp Ala Tyr Tyr Cys Ser Gly 
            20                  25                  30          


Ala Cys Gln Leu Pro Val Ala Leu Ser Gly Ser Ala Ser Asn His Ala 
        35                  40                  45              


Thr Ile Gln Ser Ile Val Arg Ala Val Gly Val Val Pro Gly Ile Pro 
    50                  55                  60                  


Glu Pro Cys Cys Val Pro Glu Lys Met Ser Ser Leu Ser Ile Leu Phe 
65                  70                  75                  80  


Tyr Asp Glu Asn Lys Asn Val Val Leu Lys Val Tyr Pro Asn Met Thr 
                85                  90                  95      


Val Glu Ser Cys Ala Cys Arg 
            100             


<210> 65
<211> 102
<212> PRT
<213> Xenopus sp.

<400> 65
Cys Lys Lys Arg His Leu Tyr Val Glu Phe Lys Asp Val Gly Trp Gln 
1               5                   10                  15      


Asn Trp Val Ile Ala Pro Gln Gly Tyr Met Ala Asn Tyr Cys Tyr Gly 
            20                  25                  30          


Glu Cys Pro Tyr Pro Leu Thr Glu Ile Leu Asn Gly Ser Asn His Ala 
        35                  40                  45              


Ile Leu Gln Thr Leu Val His Ser Ile Glu Pro Glu Asp Ile Pro Leu 
    50                  55                  60                  


Pro Cys Cys Val Pro Thr Lys Met Ser Pro Ile Ser Met Leu Phe Tyr 
65                  70                  75                  80  


Asp Asn Asn Asp Asn Val Val Leu Arg His Tyr Glu Asn Met Ala Val 
                85                  90                  95      


Asp Glu Cys Gly Cys Arg 
            100         


<210> 66
<211> 106
<212> PRT
<213> Mus sp.

<400> 66
Cys Arg Ala Arg Arg Leu Tyr Val Ser Phe Arg Glu Val Gly Trp His 
1               5                   10                  15      


Arg Trp Val Ile Ala Pro Arg Gly Phe Leu Ala Asn Tyr Cys Gln Gly 
            20                  25                  30          


Gln Cys Ala Phe Pro Met Pro Lys Ser Leu Lys Gly Gly Pro Pro Pro 
        35                  40                  45              


Leu Asn His Ala Val Leu Arg Ala Leu Met His Ala Ala Ala Pro Gly 
    50                  55                  60                  


Ala Ala Asp Leu Pro Cys Cys Val Pro Ala Arg Leu Ser Pro Ile Ser 
65                  70                  75                  80  


Val Leu Phe Phe Asp Asn Ser Asp Asn Val Val Leu Arg Gln Tyr Glu 
                85                  90                  95      


Asp Met Val Val Asp Glu Cys Gly Cys Arg 
            100                 105


<210> 67
<211> 102
<212> PRT
<213> Drosophila sp.

<400> 67
Cys Gln Met Glu Thr Leu Tyr Val Asp Phe Lys Asp Leu Gly Trp His 
1               5                   10                  15      


Asp Trp Ile Ile Ala Pro Glu Gly Tyr Gly Ala Phe Tyr Cys Ser Gly 
            20                  25                  30          


Glu Cys Asn Phe Pro Leu Asn Ala His Met Asn Ala Thr Asn His Ala 
        35                  40                  45              


Ile Val Gln Thr Leu Val His Leu Leu Glu Pro Lys Lys Val Pro Lys 
    50                  55                  60                  


Pro Cys Cys Ala Pro Thr Arg Leu Gly Ala Leu Pro Val Leu Tyr His 
65                  70                  75                  80  


Leu Asn Asp Glu Asn Val Asn Leu Lys Lys Tyr Arg Asn Met Ile Val 
                85                  90                  95      


Lys Ser Cys Gly Cys His 
            100         


<210> 68
<211> 4
<212> PRT
<213> Mus sp.

<400> 68
Gly Gly Pro Pro
1
