
                                SEQUENCE LISTING

<110> Merck & Co., Inc.
      Converso, Antonella
      Garbaccio, Robert M.
      Hartingh, Timothy John
      Kreatsoulas, Constantine
      Rickert, Keith W.
      Tasber, Edward S.

<120> INHIBITORS OF CHECKPOINT KINASES
  

<130> MRL-ONC-22263

<150> 61/065,974          
<151> 2008-02-14  

<160> 21

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Completely Synthetic DNA Sequence

<400> 1
atcagcaaga attaccattc cagacatc                                    28

<210> 2
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Completely Synthetic DNA Sequence

<400> 2
catacaactt ttcttccatt gatagccc                                    28

<210> 3
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Completely Synthetic DNA Sequence

<400> 3
gttacttggc accccagga                                              19

<210> 4
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Completely Synthetic DNA Sequence

<400> 4
catccaattt ggtaaagaat cgtgtca                                     27

<210> 5
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Completely Synthetic DNA Sequence

<400> 5
tcctcacaga acccc                                                  15

<210> 6
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Completely Synthetic DNA Sequence

<400> 6
gcacattcaa tccaatttgg acttct                                      26

<210> 7
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Completely Synthetic DNA Sequence

<400> 7
catccaattt ggtaaagaat cgtgtcat                                    28

<210> 8
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Completely Synthetic DNA Sequence

<400> 8
cagtgcttct agaaccc                                                17

<210> 9
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Completely Synthetic DNA Sequence

<400> 9
tgcatccaat ttggtaaaga atcg                                        24

<210> 10
<211> 62
<212> DNA
<213> Artificial Sequence

<220> 
<223> Completely Synthetic DNA Sequence

<400> 10
ttactggctt atcgaaatta atacgactca ctatagggag gagtcatggc agtgcccttt 60
gt                                                                62

<210> 11
<211> 64
<212> DNA
<213> Artificial Sequence

<220> 
<223> Completely Synthetic DNA Sequence

<400> 11
tagaaggcac agtcgaggct gatcagcggg tttaaactca tgcatccaat ttggtaaaga 60
atcg                                                              64

<210> 12
<211> 80
<212> DNA
<213> Artificial Sequence

<220> 
<223> Completely Synthetic DNA Sequence

<400> 12
aatccaattt ggacttctct ccagtaaaca gtgcttctag aacccctggc agcggttggt 60
caaaagaatg acacgattct                                             80

<210> 13
<211> 80
<212> DNA
<213> Artificial Sequence

<220> 
<223> Completely Synthetic DNA Sequence

<400> 13
agaatcgtgt cattcttttg accaaccgct gccaggggtt ctagaagcac tgtttactgg 60
agagaagtcc aaattggatt                                             80

<210> 14
<211> 954
<212> DNA
<213> Artificial Sequence

<220> 
<223> Completely Synthetic DNA Sequence

<400> 14
atggcagtgc cctttgtgga agactgggac ttggtgcaaa ccctgggaga aggtgcctat 60
ggagaagttc aacttgctgt gaatagagta actgaagaag cagtcgcagt gaagattgta 120
gatatgaagc gtgccgtaga ctgtccagaa aatattaaga aagagatctg tatcaataaa 180
atgctaaatc atgaaaatgt agtaaaattc tatggtcaca ggagagaagg caatatccaa 240
tatttatttc tggagtactg tagtggagga gagctttttg acagaataga gccagacata 300
ggcatgcctg aaccagatgc tcagagattc ttccatcaac tcatggcagg ggtggtttat 360
ctgcatggta ttggaataac tcacagggat attaaaccag aaaatcttct gttggatgaa 420
agggataacc tcaaaatctc agactttggc ttggcaacag tatttcggta taataatcgt 480
gagcgtttgt tgaacaagat gtgtggtact ttaccatatg ttgctccaga acttctgaag 540
agaagagaat ttcatgcaga accagttgat gtttggtcct gtggaatagt acttactgca 600
atgctcgctg gagaattgcc atgggaccaa cccagtgaca gctgtcagga gtattctgac 660
tggaaagaaa aaaaaacata cctcaaccct tggaaaaaaa tcgattctgc tcctctagct 720
ctgctgcata aaatcttagt tgagaatcca tcagcaagaa ttaccattcc agacatcaaa 780
aaagatagat ggtacaacaa acccctcaag aaaggggcaa aaaggccccg agtcacttca 840
ggtggtgtgt cagagtctcc cagtggattt tctaagcaca ttcaatccaa tttggacttc 900
tctccagtaa acagtgcttc tagaacccct ggcagcggtt ggtcaaaaga atga       954

<210> 15
<211> 317
<212> PRT
<213> Artificial Sequence

<220> 
<223> Completely Synthetic Amino Acid Sequence

<400> 15
Met Ala Val Pro Phe Val Glu Asp Trp Asp Leu Val Gln Thr Leu Gly
 1               5                  10                  15      
Glu Gly Ala Tyr Gly Glu Val Gln Leu Ala Val Asn Arg Val Thr Glu
            20                  25                  30          
Glu Ala Val Ala Val Lys Ile Val Asp Met Lys Arg Ala Val Asp Cys
        35                  40                  45              
Pro Glu Asn Ile Lys Lys Glu Ile Cys Ile Asn Lys Met Leu Asn His
    50                  55                  60                  
Glu Asn Val Val Lys Phe Tyr Gly His Arg Arg Glu Gly Asn Ile Gln
65                  70                  75                  80  
Tyr Leu Phe Leu Glu Tyr Cys Ser Gly Gly Glu Leu Phe Asp Arg Ile
                85                  90                  95      
Glu Pro Asp Ile Gly Met Pro Glu Pro Asp Ala Gln Arg Phe Phe His
            100                 105                 110         
Gln Leu Met Ala Gly Val Val Tyr Leu His Gly Ile Gly Ile Thr His
        115                 120                 125             
Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu Asp Glu Arg Asp Asn Leu
    130                 135                 140                 
Lys Ile Ser Asp Phe Gly Leu Ala Thr Val Phe Arg Tyr Asn Asn Arg
145                 150                 155                 160 
Glu Arg Leu Leu Asn Lys Met Cys Gly Thr Leu Pro Tyr Val Ala Pro
                165                 170                 175     
Glu Leu Leu Lys Arg Arg Glu Phe His Ala Glu Pro Val Asp Val Trp
            180                 185                 190         
Ser Cys Gly Ile Val Leu Thr Ala Met Leu Ala Gly Glu Leu Pro Trp
        195                 200                 205             
Asp Gln Pro Ser Asp Ser Cys Gln Glu Tyr Ser Asp Trp Lys Glu Lys
    210                 215                 220                 
Lys Thr Tyr Leu Asn Pro Trp Lys Lys Ile Asp Ser Ala Pro Leu Ala
225                 230                 235                 240 
Leu Leu His Lys Ile Leu Val Glu Asn Pro Ser Ala Arg Ile Thr Ile
                245                 250                 255     
Pro Asp Ile Lys Lys Asp Arg Trp Tyr Asn Lys Pro Leu Lys Lys Gly
            260                 265                 270         
Ala Lys Arg Pro Arg Val Thr Ser Gly Gly Val Ser Glu Ser Pro Ser
        275                 280                 285             
Gly Phe Ser Lys His Ile Gln Ser Asn Leu Asp Phe Ser Pro Val Asn
    290                 295                 300                 
Ser Ala Ser Arg Thr Pro Gly Ser Gly Trp Ser Lys Glu
305                 310                 315         


<210> 16
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Completely Synthetic DNA Sequence

<400> 16
cccggaattc accatggcag tgccctttgt ggaagactgg                       40

<210> 17
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> Completely Synthetic DNA Sequence

<400> 17
tgtgtccggc cgtcagtgat ggtgatggtg atgttctttt gaccaaccgc tgcc       54

<210> 18
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Completely Synthetic Amino Acid Sequence

<400> 18
Gly Gly Arg Ala Arg Thr Ser Ser Phe Ala Glu Pro Gly
 1               5                  10              


<210> 19
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Completely Synthetic Amino Acid Sequence

<400> 19
Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Asp
 1               5                  10                  


<210> 20
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Completely Synthetic Amino Acid Sequence

<400> 20
Gly Ser Arg Arg Pro Ser Tyr Arg Lys Ile
 1               5                  10  


<210> 21
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Completely Synthetic Amino Acid Sequence

<400> 21
Gly Leu Tyr Arg Ser Pro Ser Met Pro Glu Asn
 1               5                  10      

