                         SEQUENCE LISTING

<110>  The United States of America, as represented by the Secretary, Department         of Health and Human Services
       University of Washington
       University of Alabama at Birmingham
       Kwong, Peter D.
       Nabel, Gary J.
       Shaw, George
       Schief, William
       Yang, Zhi-yong
       Zhou, Tongqing
       Chen, Lei
       Do Kwon, Young
 
<120>  ANTIGENIC CLOAKING AND ITS USE

<130>  4239-82445-03

<150>  61/065,896
<151>  2008-02-14

<150>  61/065,114
<151>  2008-02-07

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  335
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant gp120 antigen

<400>  1

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Thr Thr Val Leu Val Asn Val Thr 
            20                  25                  30          


Val Thr Phe Asp Met Trp Lys Asn Asp Met Val Glu Gln Met Asp Glu 
        35                  40                  45              


Ala Ile Lys Thr Leu Leu Asp Thr Ser Leu Lys Pro Cys Val Lys Leu 
    50                  55                  60                  


Thr Pro Leu Ala Gly Ala Thr Ser Val Ile Thr Gln Ala Cys Pro Thr 
65                  70                  75                  80  


Val Ser Trp Glu Pro Ile Pro Ile Arg Tyr Cys Ala Pro Pro Gly Tyr 
                85                  90                  95      


Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys 
            100                 105                 110         


Thr Asn Val Ser Val Val Thr Cys Thr His Gly Ile Arg Pro Val Val 
        115                 120                 125             


Ser Ser Gln Leu Leu Leu Asn Gly Ser Leu Ala Asp Glu Glu Val Val 
    130                 135                 140                 


Ile Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln 
145                 150                 155                 160 


Leu Asn Thr Ser Val Glu Ile Asn Cys Thr Gly Ala Gly His Cys Asn 
                165                 170                 175     


Ile Thr Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Glu Lys 
            180                 185                 190         


Leu Arg Glu Gln Phe Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser 
        195                 200                 205             


Ser Gly Gly Asp Pro Glu Ile Val Thr His Trp Phe Asn Cys Gly Gly 
    210                 215                 220                 


Glu Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe 
225                 230                 235                 240 


Asn Ser Thr Trp Ser Thr Lys Gly Ser Asn Asn Thr Glu Gly Ser Asp 
                245                 250                 255     


Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Gly Gly Tyr Ala Pro 
            260                 265                 270         


Pro Val Ser Gly Val Ile Thr Cys Ser Ser Asn Ile Thr Gly Leu Leu 
        275                 280                 285             


Leu Thr Arg Asp Gly Gly Asn Asp Asn Asn Glu Ser Glu Ile Phe Arg 
    290                 295                 300                 


Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys 
305                 310                 315                 320 


Tyr Lys Val Val Lys Leu Glu Gly Ser His His His His His His 
                325                 330                 335 


<210>  2
<211>  349
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant gp120 antigen

<400>  2

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Thr Thr Val Leu Val Asn Val Thr 
            20                  25                  30          


Val Thr Phe Asp Trp Cys Lys Asn Asp Met Val Ala Gln Met Asn Thr 
        35                  40                  45              


Ala Ile Cys Thr Leu Trp Lys Thr Ser Asn Lys Pro Cys Val Lys Leu 
    50                  55                  60                  


Thr Pro Leu Cys Val Gly Ala Gly Ser Cys Asn Thr Ser Val Ile Thr 
65                  70                  75                  80  


Gln Ala Cys Pro Thr Val Ser Phe Glu Pro Ile Pro Ile Arg Tyr Cys 
                85                  90                  95      


Ala Pro Pro Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn 
            100                 105                 110         


Gly Thr Gly Pro Cys Thr Asn Val Ser Val Val Thr Cys Thr Asp Gly 
        115                 120                 125             


Ile Arg Pro Val Val Ser Ser Gln Leu Leu Leu Asn Gly Thr Leu Ala 
    130                 135                 140                 


Asp Glu Glu Val Val Ile Arg Ser Cys Asn Phe Thr Asp Asn Ala Lys 
145                 150                 155                 160 


Thr Ile Ile Val Gln Leu Asn Thr Ser Val Glu Ile Asn Cys Thr Gly 
                165                 170                 175     


Ala Gly His Cys Asn Ile Thr Arg Ala Lys Trp Asn Asn Thr Leu Lys 
            180                 185                 190         


Gln Ile Ala Glu Lys Leu Arg Glu Gln Phe Gly Asn Asn Lys Thr Ile 
        195                 200                 205             


Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Ile Val Thr His Trp 
    210                 215                 220                 


Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe 
225                 230                 235                 240 


Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser Thr Lys Gly Ser Asn Asn 
                245                 250                 255     


Thr Glu Gly Ser Asp Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile 
            260                 265                 270         


Thr Gly Met Trp Cys Thr Val Gly Lys Met Met Tyr Ala Pro Pro Val 
        275                 280                 285             


Ser Gly Val Ile Thr Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr 
    290                 295                 300                 


Arg Asp Gly Gly Asn Asp Asn Asn Glu Ser Glu Ile Phe Arg Pro Gly 
305                 310                 315                 320 


Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
                325                 330                 335     


Val Val Lys Leu Thr Gly Ser His His His His His His 
            340                 345                 


<210>  3
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant gp120 antigen

<400>  3

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Thr Thr Val Thr Val Asn Val Thr 
            20                  25                  30          


Val Thr Phe Asp Trp Cys Ala Asp Asp Met Val Ala Thr Met Asn Thr 
        35                  40                  45              


Ala Ile Cys Thr Leu Trp Lys Thr Ser Asn Asp Pro Cys Thr Lys Cys 
    50                  55                  60                  


Pro Thr Val Arg Phe Lys Pro Val Pro Ile Arg Tyr Cys Ala Pro Pro 
65                  70                  75                  80  


Gly Tyr Ala Ile Leu Lys Cys Asn Asn Arg Asp Phe Asn Gly Thr Gly 
                85                  90                  95      


Pro Cys Thr Asn Val Ser Val Val Thr Cys Thr Asp Gly Ile His Pro 
            100                 105                 110         


Val Val Ser Ser Gln Leu Leu Leu Asn Gly Thr Leu Ala Asp Glu Lys 
        115                 120                 125             


Val Val Ile Arg Ser Cys Asn Phe Ser Asp Asn Ala Lys Thr Ile Ile 
    130                 135                 140                 


Val Gln Leu Asn Thr Ser Val Glu Ile Asn Cys Thr Gly Gln Gly His 
145                 150                 155                 160 


Cys Asn Ile Thr Arg Ala Lys Trp Asn Gln Thr Leu Lys Gln Ile Ala 
                165                 170                 175     


Glu Lys Leu Arg Glu Gln Phe Gly Asn Asn Lys Thr Ile Ile Phe Arg 
            180                 185                 190         


Pro Ser Ser Gly Gly Asp Pro Glu Ile Val Thr His Trp Phe Asn Cys 
        195                 200                 205             


Gly Gly Lys Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr 
    210                 215                 220                 


Trp Phe Asn Ser Thr Trp Ser Thr Lys Gly Ser Asn Asn Thr Glu Gly 
225                 230                 235                 240 


Ser Asp Thr Ile Thr Leu Pro Cys Arg Ile Arg Ser Ile Thr Gly Met 
                245                 250                 255     


Val Cys Thr Val Gly Lys Met Ile Tyr Ala Pro Pro Val Glu Gly Val 
            260                 265                 270         


Ile Thr Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly 
        275                 280                 285             


Gly Asn Asp Asn Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp 
    290                 295                 300                 


Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Arg Val Val Arg 
305                 310                 315                 320 


Leu Thr Gly Ser His His His His His His 
                325                 330 


<210>  4
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant gp120 antigen

<400>  4

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Ser Ser Val Ser Val Asn Val Thr 
            20                  25                  30          


Gln Thr Phe Ser Trp Cys Asp Gln Asp Met Val Ala Lys Met Gln Gln 
        35                  40                  45              


Ala Ile Cys Asn Leu Trp Gln Glu Ser Asp Thr Pro Cys Asn Asp Cys 
    50                  55                  60                  


Pro Thr Lys Ala Phe Ser Pro Gln Pro Ile Gln Tyr Cys Ala Pro Asn 
65                  70                  75                  80  


Gly Lys Ala Ile Leu Lys Cys Asn Asn Glu Asn Phe Asn Gly Thr Gly 
                85                  90                  95      


Pro Cys Thr Asn Val Ser Val Val Thr Cys Thr Ala Gly Ile Ser Pro 
            100                 105                 110         


Val Val Ser Ser Gln Leu Leu Leu Asn Gly Glu Leu Ala Asp Glu Thr 
        115                 120                 125             


Val Val Ile Arg Ser Cys Asn Phe Asn Asp Asn Ala Lys Thr Ile Ile 
    130                 135                 140                 


Val Gln Leu Asn Thr Ser Val Glu Ile Asn Cys Thr Gly Glu Gly His 
145                 150                 155                 160 


Cys Asn Ile Thr Arg Ala Lys Trp Asn Ala Thr Leu Lys Gln Ile Ala 
                165                 170                 175     


Lys Lys Leu Arg Gln Gln Phe Gly Asn Asn Lys Thr Ile Ile Phe Gln 
            180                 185                 190         


Ser Ser Ser Gly Gly Asp Pro Glu Ile Val Thr His Trp Phe Asn Cys 
        195                 200                 205             


Gly Gly Arg Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr 
    210                 215                 220                 


Trp Phe Asn Ser Thr Trp Ser Thr Lys Gly Ser Asn Asn Thr Glu Gly 
225                 230                 235                 240 


Ser Asp Thr Ile Ser Leu Pro Cys Arg Ile Lys Ser Ile Thr Asp Met 
                245                 250                 255     


Lys Cys Ser Val Gly Lys Met Ile Tyr Ala Pro Pro Lys Ala Gly Asp 
            260                 265                 270         


Ile Lys Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly 
        275                 280                 285             


Gly Asn Asn Asn Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp 
    290                 295                 300                 


Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Gln Val Val Glu 
305                 310                 315                 320 


Leu Gln Gly Ser His His His His His His 
                325                 330 


<210>  5
<211>  335
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant gp120 antigen

<400>  5

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Gln Lys Val Leu Val Asn Val Thr 
            20                  25                  30          


Glu Glu Phe Asn Met Trp Asn Asn Asn Met Val Glu Leu Met His Gln 
        35                  40                  45              


Lys Ile Ala Ser Leu Ile Lys Gln Ser Leu Gln Pro Cys Val Lys Leu 
    50                  55                  60                  


Thr Pro Leu Ala Gly Ala Thr Ser Val Ile Thr Gln Ala Cys Pro Lys 
65                  70                  75                  80  


Val Asp Trp Glu Pro Gln Pro Ile Glu Tyr Cys Ala Pro Asp Gly Phe 
                85                  90                  95      


Ala Ile Leu Lys Cys Asn Asn Ser Thr Phe Asn Gly Thr Gly Pro Cys 
            100                 105                 110         


Thr Asn Val Ser Thr Val Arg Cys Thr His Gly Ile Arg Pro Val Val 
        115                 120                 125             


Ser Ser Gln Leu Leu Leu Asn Gly Ser Leu Ala Ser Ser Glu Val Val 
    130                 135                 140                 


Ile Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln 
145                 150                 155                 160 


Leu Asn Thr Ser Val Glu Ile Asn Cys Thr Gly Asp Gly Arg Cys Asn 
                165                 170                 175     


Ile Ala Arg Asp Lys Trp Asn Ala Thr Leu Gln Gln Ile Ala Ser Lys 
            180                 185                 190         


Leu Arg Gln Gln Phe Gly Ser Asn Lys Thr Ile Ile Phe Glu Gln Ser 
        195                 200                 205             


Ser Gly Gly Asp Pro Glu Ile Val Thr His Trp Phe Asn Cys Gly Gly 
    210                 215                 220                 


Glu Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe 
225                 230                 235                 240 


Asn Ser Thr Trp Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp 
                245                 250                 255     


Thr Ile Ser Leu Pro Cys Arg Ile Lys Gln Ile Gly Gly Tyr Ala Pro 
            260                 265                 270         


Pro Thr Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu 
        275                 280                 285             


Leu Thr Arg Asp Gly Gly Asp Ser Ser Asn Glu Ser Glu Ile Phe Arg 
    290                 295                 300                 


Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys 
305                 310                 315                 320 


Tyr Lys Val Thr Pro Ile Glu Gly Ser His His His His His His 
                325                 330                 335 


<210>  6
<211>  335
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant gp120 antigen

<400>  6

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Arg Glu Val Leu Val Asn Val Thr 
            20                  25                  30          


Glu Gln Phe Asn Met Trp Arg Asn Gln Met Val Glu Ala Met His Arg 
        35                  40                  45              


Glu Ile Glu Arg Leu Glu Arg Ala Lys Leu Asn Pro Cys Val Lys Leu 
    50                  55                  60                  


Thr Pro Leu Ala Gly Ala Thr Ser Val Ile Thr Gln Ala Cys Pro Lys 
65                  70                  75                  80  


Val Gln Phe Glu Pro Thr Pro Ile Thr Tyr Cys Ala Pro Glu Gly Phe 
                85                  90                  95      


Ala Ile Leu Lys Cys Asn Asn Asp Thr Phe Asn Gly Thr Gly Pro Cys 
            100                 105                 110         


Thr Asn Val Ser Thr Val Asp Cys Thr His Gly Ile Arg Pro Val Ile 
        115                 120                 125             


Ser Ser Gln Leu Leu Leu Asn Gly Ser Leu Ala Lys Gly Glu Val Val 
    130                 135                 140                 


Ile Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln 
145                 150                 155                 160 


Leu Asn Thr Ser Val Glu Ile Asn Cys Thr Gly Arg Gly Tyr Cys Asn 
                165                 170                 175     


Ile Ala Arg Lys Lys Trp Asn Glu Thr Leu Glu Gln Ile Ala Ser Lys 
            180                 185                 190         


Leu Arg Asp Gln Phe Gly Lys Asn Lys Thr Ile Ile Phe Ser Gln Ser 
        195                 200                 205             


Ser Gly Gly Asp Pro Glu Ile Val Thr His Trp Phe Asn Cys Gly Gly 
    210                 215                 220                 


Glu Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe 
225                 230                 235                 240 


Asn Ser Thr Trp Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp 
                245                 250                 255     


Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Gly Gly Tyr Ala Pro 
            260                 265                 270         


Pro Gln Asn Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu 
        275                 280                 285             


Leu Thr Arg Asp Gly Gly Pro Ser Gln Asn Glu Ser Glu Ile Phe Arg 
    290                 295                 300                 


Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys 
305                 310                 315                 320 


Tyr Lys Val Lys Ala Ile Glu Gly Ser His His His His His His 
                325                 330                 335 


<210>  7
<211>  335
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant gp120 antigen

<400>  7

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Lys Gln Val Leu Val Asn Thr Thr 
            20                  25                  30          


Ile His Phe Asn Met Trp Glu Asn Ser Met Val Gln Gln Met His Glu 
        35                  40                  45              


Gln Ile Ala Lys Leu Lys Asp Gln Gln Leu Glu Pro Cys Val Lys Leu 
    50                  55                  60                  


Thr Pro Leu Ala Gly Ala Thr Ser Val Ile Thr Gln Ala Cys Pro Val 
65                  70                  75                  80  


Val Ser Trp Ser Pro Glu Pro Ile Lys Tyr Cys Ala Pro Gln Gly Tyr 
                85                  90                  95      


Ala Ile Leu Lys Cys Asn Asn Asn Thr Phe Asn Gly Thr Gly Pro Cys 
            100                 105                 110         


Thr Asn Val Ser Glu Val Glu Cys Thr His Gly Ile Lys Pro Val Val 
        115                 120                 125             


Ser Ser Gln Leu Leu Leu Asn Gly Ser Leu Ala Asn Glu Glu Val Val 
    130                 135                 140                 


Ile Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln 
145                 150                 155                 160 


Leu Asn Ser Ser Val Glu Ile Asn Cys Thr Gly Asn Gly His Cys Asn 
                165                 170                 175     


Ile Thr Arg Ala Lys Trp Asn Gln Thr Leu Lys Gln Ile Ala Gln Lys 
            180                 185                 190         


Leu Arg Glu Gln Phe Gly Glu Asn Lys Thr Ile Ile Phe Ala Gln Ser 
        195                 200                 205             


Ser Gly Gly Asp Pro Glu Ile Val Thr His Trp Phe Asn Cys Gly Gly 
    210                 215                 220                 


Glu Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe 
225                 230                 235                 240 


Asn Ser Thr Trp Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp 
                245                 250                 255     


Thr Ile Arg Leu Pro Cys Arg Ile Lys Gln Ile Gly Gly Tyr Ala Pro 
            260                 265                 270         


Pro Thr Ser Gly Asn Ile Ser Cys Ser Ser Asn Ile Thr Gly Leu Leu 
        275                 280                 285             


Leu Thr Arg Asp Gly Gly Asn Arg Asn Asn Asn Ser Glu Ile Phe Arg 
    290                 295                 300                 


Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys 
305                 310                 315                 320 


Tyr Lys Val Val Ser Arg Glu Gly Ser His His His His His His 
                325                 330                 335 


<210>  8
<211>  335
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant gp120 antigen

<400>  8

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Lys Gln Pro Leu Gln Asn Val Thr 
            20                  25                  30          


Val Asp Phe Lys Met Trp Asp Asn Asp Met Val Asp Asp Met His Asp 
        35                  40                  45              


Gln Ile Ala Lys Glu Met Asp Glu Lys Leu Ser Pro Cys Val Lys Leu 
    50                  55                  60                  


Thr Pro Leu Ala Gly Ala Thr Ser Val Ile Thr Gln Ala Cys Pro Lys 
65                  70                  75                  80  


Thr Asn Trp Asn Pro Val Pro Ile Lys Tyr Cys Ala Pro Lys Gly Phe 
                85                  90                  95      


Ala Ile Leu Lys Cys Asn Asn Ala Thr Phe Asn Gly Thr Gly Pro Cys 
            100                 105                 110         


Thr Asn Val Ser Thr Val Glu Cys Thr His Gly Ile Arg Pro Val Val 
        115                 120                 125             


Ser Ser Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Thr Glu Val Val 
    130                 135                 140                 


Ile Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln 
145                 150                 155                 160 


Leu Asn Thr Ser Val Glu Ile Asn Cys Thr Gly Asp Gly Ser Cys Asn 
                165                 170                 175     


Ile Ala Arg Gln Lys Trp Asn Gln Thr Leu Gln Gln Ile Ala Glu Lys 
            180                 185                 190         


Leu Arg Arg Gln Phe Gly Asp Asn Lys Thr Ile Ile Phe Arg Ser Ser 
        195                 200                 205             


Ser Gly Gly Asp Pro Glu Ile Val Thr His Trp Phe Asn Cys Gly Gly 
    210                 215                 220                 


Glu Phe Phe Tyr Cys Asn Ser Thr Arg Leu Phe Asn Ser Thr Trp Phe 
225                 230                 235                 240 


Asn Ser Thr Trp Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Gln 
                245                 250                 255     


Thr Ile Gln Leu Pro Cys Arg Ile Lys Gln Ile Gly Gly Tyr Ala Pro 
            260                 265                 270         


Pro Thr Gln Asn His Ile His Cys Ser Ser Asn Ile Thr Gly Leu Leu 
        275                 280                 285             


Leu Thr Arg Asp Gly Gly Asn Arg Asn Asn Asp Ser Glu Ile Phe Arg 
    290                 295                 300                 


Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys 
305                 310                 315                 320 


Tyr Lys Val Val Lys Glu Glu Gly Ser His His His His His His 
                325                 330                 335 


<210>  9
<211>  335
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of recombinant gp120 antigen

<400>  9

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Lys Thr Pro Leu Pro Asn Val Thr 
            20                  25                  30          


Gln His Phe Asp Met Trp Asn Asn Asn Met Val Glu Glu Met His Gln 
        35                  40                  45              


Thr Ile Gln Glu Leu Leu Lys Gln Gln Leu Thr Pro Cys Val Lys Leu 
    50                  55                  60                  


Thr Pro Leu Ala Gly Ala Thr Ser Val Ile Thr Gln Ala Cys Pro Lys 
65                  70                  75                  80  


Arg Lys Trp Asp Pro Leu Pro Ile Arg Tyr Cys Ala Pro Pro Gly Phe 
                85                  90                  95      


Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys 
            100                 105                 110         


Thr Asn Val Ser Thr Val Glu Cys Thr His Gly Ile Arg Pro Val Val 
        115                 120                 125             


Ser Ser Gln Leu Leu Leu Asn Gly Ser Leu Ala Asn Thr Glu Val Val 
    130                 135                 140                 


Ile Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln 
145                 150                 155                 160 


Leu Asn Thr Ser Val Glu Ile Asn Cys Thr Gly Asn Gly His Cys Asn 
                165                 170                 175     


Ile Ala Arg Glu Lys Trp Asn Lys Thr Leu Lys Gln Ile Ala Lys Lys 
            180                 185                 190         


Leu Arg Glu Gln Phe Gly Ser Asn Lys Thr Ile Ile Phe Lys Ser Ser 
        195                 200                 205             


Ser Gly Gly Asp Pro Glu Ile Val Thr His Trp Phe Asn Cys Gly Gly 
    210                 215                 220                 


Glu Phe Phe Tyr Cys Asn Ser Thr Lys Leu Phe Asn Ser Thr Trp Phe 
225                 230                 235                 240 


Asn Ser Thr Trp Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asn 
                245                 250                 255     


Thr Ile Glu Leu Pro Cys Arg Ile Lys Gln Ile Gly Gly Tyr Ala Pro 
            260                 265                 270         


Pro Thr Glu Asp Asn Ile Ser Cys Ser Ser Asn Ile Thr Gly Leu Leu 
        275                 280                 285             


Leu Thr Arg Asp Gly Gly Asn Arg Asp Asn Asn Ser Glu Ile Phe Arg 
    290                 295                 300                 


Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys 
305                 310                 315                 320 


Tyr Lys Val Val Gln Arg Glu Gly Ser His His His His His His 
                325                 330                 335 


<210>  10
<211>  1008
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Neucleic acid sequence of recombinant gp120 antigen

<400>  10
atgcccatgg gcagcctgca gcccctggcc accctgtacc tgctgggcat gctggtggcc       60

agcgtgctgg ccaccaccgt gctggtgaac gtgaccgtga ccttcgacat gtggaagaac      120

gacatggtgg agcagatgga cgaggccatc aagaccctgc tggacaccag cctgaagccc      180

tgcgtgaagc tgacccccct ggccggcgcc accagcgtga tcacccaggc ctgccccacc      240

gtgagctggg agcccatccc catcaggtac tgcgcccccc ccggctacgc catcctgaag      300

tgcaacaaca agaccttcaa cggcaccggc ccctgcacca acgtgagcgt ggtgacctgc      360

acccacggca tcaggcccgt ggtgagcagc cagctgctgc tgaacggcag cctggccgac      420

gaggaggtgg tgatcaggag cgtgaacttc accgacaacg ccaagaccat catcgtgcag      480

ctgaacacca gcgtggagat caactgcacc ggcgccggcc actgcaacat caccagggcc      540

aagtggaaca acaccctgaa gcagatcgcc gagaagctga gggagcagtt cggcaacaac      600

aagaccatca tcttcaagca gagcagcggc ggcgaccccg agatcgtgac ccactggttc      660

aactgcggcg gcgagttctt ctactgcaac agcacccagc tgttcaacag cacctggttc      720

aacagcacct ggagcaccaa gggcagcaac aacaccgagg gcagcgacac catcaccctg      780

ccctgcagga tcaagcagat cggcggctac gccccccccg tgagcggcgt gatcacctgc      840

agcagcaaca tcaccggcct gctgctgacc agggacggcg gcaacgacaa caacgagagc      900

gagatcttca ggcccggcgg cggcgacatg agggacaact ggaggagcga gctgtacaag      960

tacaaggtgg tgaagctgga gggatcccat catcatcatc atcattag                  1008


<210>  11
<211>  1050
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Neucleic acid sequence of recombinant gp120 antigen

<400>  11
atgcccatgg gcagcctgca gcccctggcc accctgtacc tgctgggcat gctggtggcc       60

agcgtgctgg ccaccaccgt gctggtgaac gtgaccgtga ccttcgactg gtgcaagaac      120

gacatggtgg cccagatgaa caccgccatc tgcaccctgt ggaagaccag caacaagccc      180

tgcgtgaagc tgacccccct gtgcgtgggc gccggcagct gcaacaccag cgtgatcacc      240

caggcctgcc ccaccgtgag cttcgagccc atccccatca ggtactgcgc cccccccggc      300

tacgccatcc tgaagtgcaa caacaagacc ttcaacggca ccggcccctg caccaacgtg      360

agcgtggtga cctgcaccga cggcatcagg cccgtggtga gcagccagct gctgctgaac      420

ggcaccctgg ccgacgagga ggtggtgatc aggagctgca acttcaccga caacgccaag      480

accatcatcg tgcagctgaa caccagcgtg gagatcaact gcaccggcgc cggccactgc      540

aacatcacca gggccaagtg gaacaacacc ctgaagcaga tcgccgagaa gctgagggag      600

cagttcggca acaacaagac catcatcttc aagcagagca gcggcggcga ccccgagatc      660

gtgacccact ggttcaactg cggcggcgag ttcttctact gcaacagcac ccagctgttc      720

aacagcacct ggttcaacag cacctggagc accaagggca gcaacaacac cgagggcagc      780

gacaccatca ccctgccctg caggatcaag cagatcaccg gcatgtggtg caccgtgggc      840

aagatgatgt acgccccccc cgtgagcggc gtgatcacct gcagcagcaa catcaccggc      900

ctgctgctga ccagggacgg cggcaacgac aacaacgaga gcgagatctt caggcccggc      960

ggcggcgaca tgagggacaa ctggaggagc gagctgtaca agtacaaggt ggtgaagctg     1020

accggatccc atcatcatca tcatcattag                                      1050


<210>  12
<211>  1065
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Neucleic acid sequence of recombinant gp120 antigen

<400>  12
atgcctatgg gatctctgca gcctctggcc acactgtatc tgctgggaat gctggtcgct       60

tctgtgctgg ccacaaccgt gaccgtgaat gtgaccgtga ccttcgattg gtgcgccgat      120

gatatggtgg ctacaatgaa caccgccatc tgcaccctgt ggaaaaccag caacgacccc      180

tgcaccaagt gtcctaccgt gcggtttaag cccgtgccca tcagatattg tgcccctcct      240

ggctatgcca tcctgaagtg caacaaccgg gactttaatg gcaccggccc ttgcacaaat      300

gtgtccgtgg tgacctgtac agatggcatc caccctgtgg tgtctagtca gctgctgctg      360

aatggcacac tggccgatga gaaggtggtg atcagaagct gcaacttcag cgacaacgcc      420

aagaccatca tcgtgcagct gaacaccagc gtggagatca attgtacagg ccagggccac      480

tgcaatatca cccgggccaa gtggaatcag accctgaagc agatcgccga gaagctgaga      540

gagcagttcg gcaacaacaa gacaatcatc ttcaggccta gctctggcgg agatcctgag      600

atcgtgaccc actggttcaa ttgcggcggc aagttcttct actgcaacag cacccagctg      660

ttcaacagca cctggttcaa ctctacttgg agcaccaagg gcagcaacaa caccgagggc      720

agcgatacca tcaccctgcc ctgcaggatc agatctatca ccggcatggt gtgcacagtg      780

ggcaagatga tctacgcccc tcctgtggaa ggcgtgatca cctgcagcag caacatcaca      840

ggcctgctgc tgacaagaga tggcggcaac gacaacaacg agagcgagat ctttagacct      900

ggcggcggag acatgaggga caattggcgg agcgagctgt acaagtacag agtggtgcgg      960

ctgaccggat ccggcctgaa cgacatcttc gaggcccaga agatcgagtg gcacgagctg     1020

gaggtgctgt tccagggccc aggccaccac caccaccacc actga                     1065


<210>  13
<211>  993
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Neucleic acid sequence of recombinant gp120 antigen

<400>  13
atgcctatgg gatctctgca gcctctggcc acactgtatc tgctgggaat gctggtcgct       60

tctgtgctgg cctctagcgt gtccgtgaat gtgacccaga ccttctcttg gtgcgaccag      120

gatatggtgg ccaaaatgca gcaggccatc tgcaatctgt ggcaggaaag cgacaccccc      180

tgcaatgatt gtcccaccaa ggcctttagc cctcagccta tccagtactg cgcccctaat      240

ggcaaggcca tcctgaagtg caacaacgag aacttcaacg gcaccggccc ttgtacaaat      300

gtgtccgtgg tgacctgtac agccggcatt agccctgtgg tgtctagtca gctgctgctg      360

aatggcgaac tggccgatga gacagtggtg atcagaagct gcaacttcaa cgacaacgcc      420

aagaccatca tcgtgcagct gaacaccagc gtggagatca attgtacagg cgagggccac      480

tgcaatatca cccgggccaa gtggaatgcc accctgaagc agatcgccaa gaagctgaga      540

cagcagttcg gcaacaacaa gacaattatc ttccagtcct cttctggcgg agatcctgag      600

atcgtgaccc actggttcaa ttgcggcggc agattcttct actgcaacag cacccagctg      660

ttcaacagca cctggttcaa ctctacttgg agcaccaagg gcagcaacaa caccgagggc      720

agcgatacaa tcagcctgcc ctgccggatc aagagcatca ccgacatgaa gtgcagcgtg      780

ggcaagatga tctacgcccc tcctaaggcc ggcgacatca agtgtagcag caacatcaca      840

ggcctgctgc tgacaagaga tggcggcaac aataacaacg agagcgagat ctttagacct      900

ggcggcggag acatgaggga caattggcgg agcgagctgt acaagtacca ggtggtggag      960

ctgcagggat cccatcatca tcatcatcat tag                                   993


<210>  14
<211>  1008
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Neucleic acid sequence of recombinant gp120 antigen

<400>  14
atgcctatgg gatctctgca gcctctggcc acactgtatc tgctgggcat gctggtcgct       60

tcagtgctgg ctcagaaagt gctggtgaac gtgaccgagg aattcaacat gtggaacaac      120

aacatggtgg agctgatgca ccagaagatc gccagcctga tcaaacagag cctgcagccc      180

tgtgtgaaac tgacacctct ggctggcgcc acatctgtga tcacccaggc ctgtcccaaa      240

gtggattggg agccccagcc tatcgagtat tgcgcccctg atggcttcgc catcctgaag      300

tgcaacaaca gcaccttcaa tggcaccggc ccctgtacca atgtgtctac cgtgcggtgt      360

acacacggca tcagacctgt ggtgtctagc cagctgctgc tgaatggctc tctggccagc      420

tctgaggtgg tgatcagaag cgtgaacttc accgacaacg ccaagaccat catcgtgcag      480

ctgaacacca gcgtggagat caattgtacc ggcgacggca gatgcaatat cgcccgggac      540

aagtggaatg ccacactgca gcagatcgcc tccaagctga gacagcagtt cggcagcaac      600

aagacaatca tcttcgagca gtcctctggc ggagatccag aaatcgtgac ccactggttc      660

aactgtggcg gcgagttctt ctactgcaac agcacccagc tgttcaactc cacctggttc      720

aatagcacct ggtctactga gggaagcaat aacaccgagg gctccgatac catcagcctg      780

ccctgcagaa tcaagcagat cggcggctat gctcctccta ccagaggcca gatccggtgc      840

agcagcaata tcacaggcct gctgctgaca agagatggcg gcgacagcag caacgagagc      900

gagatcttta gacctggcgg cggagacatg agagacaatt ggcggagcga gctgtacaag      960

tacaaagtga cccccatcga gggatcccat catcatcatc atcattag                  1008


<210>  15
<211>  1008
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Neucleic acid sequence of recombinant gp120 antigen

<400>  15
atgcctatgg gatctctgca gcctctggcc acactgtatc tgctgggcat gctggtcgct       60

tcagtgctgg ctagagaagt gctggtgaac gtgaccgagc agttcaacat gtggcggaac      120

cagatggtgg aggccatgca cagagagatc gagcggctgg aaagagccaa gctgaacccc      180

tgtgtgaaac tgacacctct ggctggcgcc acatctgtga tcacccaggc ctgccctaag      240

gtgcagttcg agcccacccc tatcacatac tgcgcccctg agggctttgc catcctgaag      300

tgcaacaacg acaccttcaa tggcaccggc ccctgtacca atgtgtccac cgtggactgt      360

acacacggca tcagacccgt gatctccagc cagctgctcc tgaatggctc tctggccaag      420

ggcgaggtgg tgatcagaag cgtgaacttc accgacaacg ccaagaccat catcgtgcag      480

ctgaacacca gcgtggagat caattgcacc ggcagaggct actgcaatat cgcccggaag      540

aagtggaacg agacactgga acagatcgcc agcaagctga gagatcagtt cggcaagaac      600

aagacaatca tcttcagcca gtcctctggg ggagatccag aaatcgtgac ccactggttc      660

aattgtggcg gcgagttctt ctactgcaac agcacccagc tgttcaacag cacctggttc      720

aactccacct ggtctacaga aggaagcaat aacaccgagg gctccgatac catcaccctg      780

ccctgcagaa tcaagcagat cggcggctat gctcctcctc agaacggcca gatccggtgc      840

agcagcaata tcacaggcct gctgctgaca agagatggcg gccctagcca gaacgagagc      900

gagatcttta gacctggcgg cggagacatg agagacaatt ggcggagcga gctgtacaag      960

tacaaagtga aggccatcga gggatcccat catcatcatc atcattag                  1008


<210>  16
<211>  1008
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Neucleic acid sequence of recombinant gp120 antigen

<400>  16
atgcctatgg gatctctgca gcctctggcc acactgtatc tgctgggcat gctggtcgct       60

tcagtgctgg ctaaacaggt gctggtgaac accaccatcc acttcaacat gtgggagaac      120

agcatggtgc agcagatgca cgagcagatc gccaagctga aggaccagca gctggaacct      180

tgtgtgaagc tgacacctct ggctggcgcc acatctgtga tcacacaggc ctgccctgtg      240

gtgtcttgga gccccgagcc tatcaagtat tgcgcccctc agggctacgc catcctgaag      300

tgcaacaaca acaccttcaa cggcaccggc ccctgtacaa atgtgtccga ggtggagtgt      360

acacacggca tcaaaccagt ggtctcaagc cagctgctgc tgaatggcag cctggccaac      420

gaggaagtgg tgatcagaag cgtgaacttc accgacaacg ccaagaccat catcgtgcag      480

ctgaacagca gcgtggagat caattgcacc ggcaacggcc actgcaatat cacccgggcc      540

aagtggaatc agaccctgaa gcagattgcc cagaagctga gagagcagtt cggcgagaac      600

aagacaatca tcttcgccca gagcagtggc ggagatcctg agatcgtgac ccactggttc      660

aactgtggcg gcgagttctt ctactgcaac tctacccagc tctttaattc cacatggttc      720

aattccacct ggtctacaga aggaagcaat aacaccgagg gctccgacac aatcagactg      780

ccctgccgga tcaagcagat cggaggatac gcccctccta ccagcggcaa tatcagctgc      840

agcagcaaca tcaccggcct gctgctgaca agagatggcg gcaaccggaa caacaacagc      900

gagatcttca gacctggcgg cggagacatg agagacaatt ggcggagcga gctgtacaag      960

tacaaggtgg tgtcccggga gggatcccat catcatcatc atcattag                  1008


<210>  17
<211>  1008
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Neucleic acid sequence of recombinant gp120 antigen

<400>  17
atgcctatgg gatctctgca gcctctggcc acactgtatc tgctgggcat gctggtcgct       60

tcagtgctgg ctaaacagcc cctgcagaac gtgaccgtgg acttcaagat gtgggacaac      120

gacatggtgg acgacatgca cgaccagatc gccaaagaga tggacgagaa gctgtcccct      180

tgtgtgaaac tgacacctct ggctggcgcc acatctgtga tcacccaggc ctgccccaag      240

accaattgga accccgtgcc catcaagtac tgcgccccca agggctttgc catcctgaag      300

tgcaacaacg ccacctttaa tggcaccggc ccctgcacaa atgtgtccac cgtggagtgt      360

acacacggca tcagacctgt ggtgtctagc cagctgctgc tgaatggctc tctggccgag      420

acagaggtgg tgatcagaag cgtgaacttc accgacaacg ccaagaccat catcgtgcag      480

ctgaacacca gcgtggagat caattgtacc ggcgacggca gctgtaatat cgcccggcag      540

aagtggaatc agaccctgca gcagatcgcc gagaagctga gaaggcagtt cggcgacaac      600

aagacaatca tcttcagaag cagctcagga ggagatcctg agatcgtcac ccactggttc      660

aactgtggcg gcgagttctt ctactgcaac agcacccggc tgttcaacag cacctggttc      720

aattccacct ggtccaccga gggcagcaat aatacagagg gcagccagac cattcagctc      780

ccttgtagga tcaagcagat cggcggctat gcccctccta cccagaacca catccactgc      840

agcagcaata tcaccggcct gctgctgaca agagatggcg gcaaccggaa caacgacagc      900

gagatcttta gacctggcgg cggagacatg agagacaatt ggcggagcga gctgtacaag      960

tacaaggtgg tgaaagagga aggatcccat catcatcatc atcattag                  1008


<210>  18
<211>  1008
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Neucleic acid sequence of recombinant gp120 antigen

<400>  18
atgcctatgg gatctctgca gcctctggcc acactgtatc tgctgggcat gctggtcgct       60

agcgtgctgg ctaagacccc tctgcctaac gtgacccagc acttcgacat gtggaacaac      120

aacatggtgg aggaaatgca ccagaccatc caggaactgc tgaaacagca gctcacccct      180

tgtgtgaaac tgacacctct ggctggcgcc acatctgtga tcacccaggc ctgccccaaa      240

agaaaatggg accccctgcc catcagatat tgcgcccctc ctggctttgc catcctgaag      300

tgcaacaaca agaccttcaa tggaaccgga ccctgtacaa atgtgtccac cgtggagtgt      360

acacacggca tcagacctgt ggtgtctagc cagctgctcc tgaatggcag cctggccaat      420

accgaggtgg tgatcagaag cgtgaacttc accgacaacg ccaagaccat catcgtgcag      480

ctgaacacca gcgtggagat caattgcacc ggcaacggcc actgtaatat cgcccgggag      540

aagtggaata agaccctgaa gcagatcgcc aagaagctga gagagcagtt cggcagcaac      600

aagacaatca tcttcaagag cagcagcggc ggagatccag aaatcgtgac ccactggttc      660

aactgtggcg gcgagttctt ctactgcaac agcaccaagc tgttcaacag cacctggttc      720

aattccacct ggtccacaga gggaagcaat aacaccgagg gctccaacac aatcgagctg      780

ccctgcagaa tcaagcagat cggcggctat gcccctccta ccgaggacaa catcagctgc      840

agcagcaaca tcacaggcct gctgctgaca agagatggcg gcaatagaga taacaacagc      900

gagatcttca gacctggagg aggggacatg agagacaatt ggcggagcga gctgtacaag      960

tacaaggtgg tgcagcggga gggatcccat catcatcatc atcattag                  1008


<210>  19
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of recombinant gp120 antigen

<400>  19

Gln Leu Ala Val Leu Asn Val Thr Gln Ser Phe Asp Ala Tyr Asn His 
1               5                   10                  15      


Thr Met Val Gln Glu Ala Ile Asp Asn Val Trp Gln Leu Trp Glu Thr 
            20                  25                  30          


Thr Ile Lys Pro Cys Val Lys Leu Ser Pro Ile Cys Ile Gly Ala Gly 
        35                  40                  45              


His Cys Asn Thr Ser Val Val Gln Glu Ser Cys Asp Thr His Tyr Trp 
    50                  55                  60                  


Asp Ala Val Arg Ile Arg Tyr Cys Ala Pro Pro Gly Tyr Ala Ile Met 
65                  70                  75                  80  


Arg Cys Asn Asn Lys Thr Phe Asn Gly Thr Met Pro Cys Ser Asn Val 
                85                  90                  95      


Ser Val Ser Ser Cys Thr Arg Met Ile Glu Pro Val Val Ser Thr Gln 
            100                 105                 110         


Leu Leu Leu Asn Gly Ser Glu Ala Arg Thr Tyr Val Tyr Trp Arg Ser 
        115                 120                 125             


Val Asn Phe Thr Glu Asn Ala Thr Ile Ile Ile Val Asn Leu Asn Thr 
    130                 135                 140                 


Ser Val Thr Ile Lys Cys Arg Gly Ala Gly Trp Cys Asn Ile Ser Gly 
145                 150                 155                 160 


Ala Gln Trp Asn Asn Thr Leu Lys Glu Ile Ala Gln Thr Leu Val Lys 
                165                 170                 175     


His Pro Arg Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly 
            180                 185                 190         


Asp Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe 
        195                 200                 205             


Tyr Cys Asn Ser Thr Trp Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr 
    210                 215                 220                 


Tyr Thr Ser Asp Gly Thr Asn Asn Thr Lys Glu Gln His Arg Ile Tyr 
225                 230                 235                 240 


Leu Pro Cys Arg Ile Arg Gln Ile Val Thr Thr Trp His Arg Val Gly 
                245                 250                 255     


Lys Asn Val Tyr Leu Pro Pro Arg Glu Gly Asp Leu Thr Cys Asn Ser 
            260                 265                 270         


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asp Gly Asn Asn 
        275                 280                 285             


Glu Ser Ile Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp 
    290                 295                 300                 


Arg Ser Asp Leu Tyr Asp Tyr Gln Leu Val Glu Ile Thr 
305                 310                 315         


<210>  20
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of recombinant gp120 antigen

<400>  20

Glu Val Val Leu Val Asn Val Thr Glu Asn Phe Asn Trp Cys Lys Asn 
1               5                   10                  15      


Asp Met Val Glu Gln Met His Glu Asp Ile Cys Ser Leu Trp Asp Gln 
            20                  25                  30          


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Gly Ala Gly 
        35                  40                  45              


Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe 
    50                  55                  60                  


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
65                  70                  75                  80  


Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr Asn Val 
                85                  90                  95      


Ser Thr Val Cys Thr His Gly Ile Arg Pro Val Val Ser Ser Gln Leu 
            100                 105                 110         


Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg Ser Cys 
        115                 120                 125             


Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn Thr Ser 
    130                 135                 140                 


Val Glu Ile Asn Cys Thr Gly Ala Gly His Cys Asn Ile Ser Arg Ala 
145                 150                 155                 160 


Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln 
                165                 170                 175     


Phe Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp 
            180                 185                 190         


Pro Glu Ile Val Thr His Trp Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
        195                 200                 205             


Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp 
    210                 215                 220                 


Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu 
225                 230                 235                 240 


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Cys Lys Val Gly Lys 
                245                 250                 255     


Met Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile Arg Cys Ser Ser Asn 
            260                 265                 270         


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Ser Asn Asn Glu 
        275                 280                 285             


Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
    290                 295                 300                 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu 
305                 310                 315     


<210>  21
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  21

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe 
            20                  25      


<210>  22
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide sequence

<400>  22

Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
1               5                   10                  15      


Gly Ile 
        


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic hexapeptide.

<400>  23

Asn Thr Arg Gly Arg Arg 
1               5       


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  24

Val Lys Leu Thr Pro Leu Ala Gly Ala Thr Ser Val Ile Thr Gln Ala 
1               5                   10                  15      


