
                                SEQUENCE LISTING

<110> Merck & Co., Inc.
      Condra, Jon H.
      Cubbon, Rose M.
      Hammond, Holly A.
      McCabe, Timothy
      Pandit, Shilpa
      Peterson, Laurence B.
      Santoro, Joseph C.
      Sitlani, Ayesha
      Wood, Dana D.

<120> 1B20 PCSK9 ANTAGONISTS
  

<130> MRL-ACV-22541

<150> 61/063,980          
<151> 2008-02-07  

<160> 109

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 220
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC; 1B20

<400> 1
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Ser Ser Phe Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Ala
    210                 215                 220 


<210> 2
<211> 660
<212> DNA
<213> Artificial Sequence

<220> 
<223> LC; 1B20

<400> 2
gatatcgtga tgacccagag cccggatagc ctggcggtga gcctgggcga acgtgcgacc 60
attaactgca gaagcagcca gtctgttctt tattcttcta acaataagaa ttatctggct 120
tggtaccagc agaaaccagg tcagccgccg aaactattaa tttattgggc ttctactcgt 180
gaaagcgggg tcccggatcg ttttagcggc tctggatccg gcactgattt taccctgacc 240
atttcgtccc tgcaagctga agacgtggcg gtgtattatt gccagcagta ttcttctttt 300
cctattacct ttggccaggg tacgaaagtt gaaattaaac gtacggtggc tgctccgagc 360
gtgtttattt ttccgccgag cgatgaacaa ctgaaaagcg gcacggcgag cgtggtgtgc 420
ctgctgaaca acttttatcc gcgtgaagcg aaagttcagt ggaaagtaga caacgcgctg 480
caaagcggca acagccagga aagcgtgacc gaacaggata gcaaagatag cacctattct 540
ctgagcagca ccctgaccct gagcaaagcg gattatgaaa aacataaagt gtatgcgtgc 600
gaagtgaccc atcaaggtct gagcagcccg gtgactaaat cttttaatcg tggcgaggcc 660


<210> 3
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1; 1B20

<400> 3
Arg Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu
 1               5                  10                  15      
Ala
    


<210> 4
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> VL CDR1; 1B20

<400> 4
agaagcagcc agtctgttct ttattcttct aacaataaga attatctggc t          51

<210> 5
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR2; 1B20

<400> 5
Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser
 1               5                  10      


<210> 6
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> VL CDR2; 1B20

<400> 6
ctattaattt attgggcttc tactcgtgaa agc                              33

<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR3; 1B20

<400> 7
Gln Gln Tyr Ser Ser Phe Pro Ile
 1               5              


<210> 8
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> VL CDR3; 1B20

<400> 8
cagcagtatt cttcttttcc tatt                                        24

<210> 9
<211> 243
<212> PRT
<213> Artificial Sequence

<220> 
<223> FD CHAIN; 1B20

<400> 9
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Tyr Lys Pro Leu Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Glu Phe Glu
    210                 215                 220                 
Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Pro His His His
225                 230                 235                 240 
His His His
            


<210> 10
<211> 729
<212> DNA
<213> Artificial Sequence

<220> 
<223> FD CHAIN; 1B20

<400> 10
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt 60
agctgcaaag gttccggata ttcctttact aattattgga tttcttgggt gcgccagatg 120
cctgggaagg gtctcgagtg gatgggcatt atctatccgg gtgatagcta taccaattat 180
tctccgagct ttcagggcca ggtgaccatt agcgcggata aaagcattag caccgcgtat 240
cttcaatgga gcagcctgaa agcgagcgat acggccatgt attattgcgc gcgtgattat 300
tggtataagc ctctttttga tatttggggc caaggcaccc tggtgacggt tagctcagcg 360
tcgaccaaag gtccaagcgt gtttccgctg gctccgagca gcaaaagcac cagcggcggc 420
acggctgccc tgggctgcct ggttaaagat tatttcccgg aaccagtcac cgtgagctgg 480
aacagcgggg cgctgaccag cggcgtgcat acctttccgg cggtgctgca aagcagcggc 540
ctgtatagcc tgagcagcgt tgtgaccgtg ccgagcagca gcttaggcac tcagacctat 600
atttgcaacg tgaaccataa accgagcaac accaaagtgg ataaaaaagt ggaaccgaaa 660
agcgaattcg agcagaagct gatctctgag gaggatctga acggcgcgcc gcaccatcat 720
caccatcac                                                         729

<210> 11
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20

<400> 11
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Tyr Lys Pro Leu Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 12
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> VH; 1B20

<400> 12
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt 60
agctgcaaag gttccggata ttcctttact aattattgga tttcttgggt gcgccagatg 120
cctgggaagg gtctcgagtg gatgggcatt atctatccgg gtgatagcta taccaattat 180
tctccgagct ttcagggcca ggtgaccatt agcgcggata aaagcattag caccgcgtat 240
cttcaatgga gcagcctgaa agcgagcgat acggccatgt attattgcgc gcgtgattat 300
tggtataagc ctctttttga tatttggggc caaggcaccc tggtgacggt tagctca    357

<210> 13
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR1; 1B20

<400> 13
Gly Tyr Ser Phe Thr Asn Tyr Trp Ile Ser
 1               5                  10  


<210> 14
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> VH CDR1; 1B20

<400> 14
ggatattcct ttactaatta ttggatttct                                  30

<210> 15
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR2; 1B20

<400> 15
Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro
 1               5                  10                  15      
Ser Phe Gln Gly
            20  


<210> 16
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> VH CDR2; 1B20

<400> 16
tggatgggca ttatctatcc gggtgatagc tataccaatt attctccgag ctttcagggc 60


<210> 17
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR3; 1B20

<400> 17
Asp Tyr Trp Tyr Lys Pro Leu Phe Asp Ile
 1               5                  10  


<210> 18
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> VH CDR3; 1B20

<400> 18
gattattggt ataagcctct ttttgatatt                                  30

<210> 19
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> INTERNAL PROCESSING SITE

<400> 19
Ser Ser Val Phe Ala Gln
 1               5      


<210> 20
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> INTERNAL PROCESSING SITE

<400> 20
Ser Ile Pro Trp Asn Leu
 1               5      


<210> 21
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> CONTAINS FC DOMAIN OF IGG1

<400> 21
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 22
<211> 326
<212> PRT
<213> Artificial Sequence

<220> 
<223> CONTAINS FC DOMAIN OF IGG2

<400> 22
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
        115                 120                 125             
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
    130                 135                 140                 
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly
145                 150                 155                 160 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn
                165                 170                 175     
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp
            180                 185                 190         
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro
        195                 200                 205             
Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
    210                 215                 220                 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
225                 230                 235                 240 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
                245                 250                 255     
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
            260                 265                 270         
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
        275                 280                 285             
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
    290                 295                 300                 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
305                 310                 315                 320 
Ser Leu Ser Pro Gly Lys
                325     


<210> 23
<211> 327
<212> PRT
<213> Artificial Sequence

<220> 
<223> CONTAINS FC DOMAIN OF IGG4

<400> 23
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys
                325         


<210> 24
<211> 326
<212> PRT
<213> Artificial Sequence

<220> 
<223> CONTAINS FC DOMAIN OF IGG2M4

<400> 24
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
        115                 120                 125             
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
    130                 135                 140                 
Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly
145                 150                 155                 160 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn
                165                 170                 175     
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
            180                 185                 190         
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro
        195                 200                 205             
Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
    210                 215                 220                 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
225                 230                 235                 240 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
                245                 250                 255     
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
            260                 265                 270         
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
        275                 280                 285             
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
    290                 295                 300                 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
305                 310                 315                 320 
Ser Leu Ser Pro Gly Lys
                325     


<210> 25
<211> 445
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 IgG2m4 Heavy Chain

<400> 25
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Tyr Lys Pro Leu Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Thr Ser
            180                 185                 190         
Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
        275                 280                 285             
Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
305                 310                 315                 320 
Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
                325                 330                 335     
Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
            340                 345                 350         
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445 


<210> 26
<211> 220
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 IgG Light Chain

<400> 26
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Ser Ser Phe Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215                 220 


<210> 27
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL; 1B20

<400> 27
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Ser Ser Phe Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
            100                 105                 110         
Lys Arg
        


<210> 28
<211> 342
<212> DNA
<213> Artificial Sequence

<220> 
<223> VL; 1B20

<400> 28
gatatcgtga tgacccagag cccggatagc ctggcggtga gcctgggcga acgtgcgacc 60
attaactgca gaagcagcca gtctgttctt tattcttcta acaataagaa ttatctggct 120
tggtaccagc agaaaccagg tcagccgccg aaactattaa tttattgggc ttctactcgt 180
gaaagcgggg tcccggatcg ttttagcggc tctggatccg gcactgattt taccctgacc 240
atttcgtccc tgcaagctga agacgtggcg gtgtattatt gccagcagta ttcttctttt 300
cctattacct ttggccaggg tacgaaagtt gaaattaaac gt                    342

<210> 29
<211> 1335
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1B20 IgG2m4 Heavy Chain

<400> 29
caggtgcaat tggttcagag cggcgcggaa gtgaaaaaac cgggcgaaag cctgaaaatt 60
agctgcaaag gttccggata ttcctttact aattattgga tttcttgggt gcgccagatg 120
cctgggaagg gtctcgagtg gatgggcatt atctatccgg gtgatagcta taccaattat 180
tctccgagct ttcagggcca ggtgaccatt agcgcggata aaagcattag caccgcgtat 240
cttcaatgga gcagcctgaa agcgagcgat acggccatgt attattgcgc gcgtgattat 300
tggtataagc ctctttttga tatttggggc caaggcaccc tggtgacggt tagctcagca 360
tccaccaagg gcccatccgt cttccccctg gcgccctgct ccaggagcac ctccgagagc 420
acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480
aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540
ctctactccc tcagcagcgt ggtgaccgtg acctccagca actttggcac gcagacctac 600
acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagacagt tgagcggaaa 660
tgctgcgtgg agtgcccacc atgcccagca cctccagtgg ccggaccatc agtcttcctg 720
ttccccccaa aacccaagga cactctcatg atctcccgga cccctgaggt cacgtgcgtg 780
gtggtggacg tgagccagga agaccccgag gtccagttca actggtacgt ggatggcgtg 840
gaggtgcata atgccaagac aaagccgcgg gaggagcagt tcaacagcac gttccgtgtg 900
gtcagcgtcc tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag 960
gtctccaaca aaggcctccc gtcctccatc gagaaaacca tctccaaaac caaagggcag 1020
ccccgagagc cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag 1080
gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag 1140
agcaatgggc agccggagaa caactacaag accacgcctc ccatgctgga ctccgacggc 1200
tccttcttcc tctacagcaa gctaaccgtg gacaagagca ggtggcagca ggggaatgtc 1260
ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacacagaa gagcctctcc 1320
ctgtctcctg gtaaa                                                  1335

<210> 30
<211> 660
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1B20 IgG Light Chain

<400> 30
gatatcgtga tgacccagag cccggatagc ctggcggtga gcctgggcga acgtgcgacc 60
attaactgca gaagcagcca gtctgttctt tattcttcta acaataagaa ttatctggct 120
tggtaccagc agaaaccagg tcagccgccg aaactattaa tttattgggc ttctactcgt 180
gaaagcgggg tcccggatcg ttttagcggc tctggatccg gcactgattt taccctgacc 240
atttcgtccc tgcaagctga agacgtggcg gtgtattatt gccagcagta ttcttctttt 300
cctattacct ttggccaggg tacgaaagtt gaaattaaac gtacggtggc tgcaccatct 360
gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc 420
ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc 480
caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc 540
ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc 600
gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt 660


<210> 31
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 31
acagatgcca gatgcgatat cgtgatgacc caga                             34

<210> 32
<211> 36
<212> DNA
<213> PArtificial Sequence

<220> 
<223> Primer

<400> 32
tgcagccacc gtacgtttaa tttcaacttt cgtacc                           36

<210> 33
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 33
acaggtgtcc actcgcaggt gcaattggtt cagagc                           36

<210> 34
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 34
gcccttggtg gatgctgagc taaccgtcac cagggt                           36

<210> 35
<211> 8539
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1B20 IgG2m4 HC Plasmid

<400> 35
cgatagattg tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa 60
tcagcatcca tgttggaatt taatcgcggc ctcgagcaag acgtttcccg ttgaatatgg 120
ctcataacac cccttgtatt actgtttatg taagcagaca gttttattgt tcatgatgat 180
atatttttat cttgtgcaat gtaacatcag agattttgag acacaacgtg gctttccccc 240
cccccccatt attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa 300
tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct 360
gacgtctaag aaaccattat tatcatgaca ttaacctata aaaataggcg tatcacgagg 420
ccctttcgtc tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg 480
gagacggtca cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg 540
tcagcgggtg ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta 600
ctgagagtgc accatatgct taattaacgc ggggcagtgc atgtaatccc ttcagttggt 660
tggtacaact tgccaactgg gccctgttcc acatgtgaca cgggggggga ccaaacacaa 720
aggggttctc tgactgtagt tgacatcctt ataaatggat gtgcacattt gccaacactg 780
agtggctttc atcctggagc agactttgca gtctgtggac tgcaacacaa cattgccttt 840
atgtgtaact cttggctgaa gctcttacac caatgctggg ggacatgtac ctcccagggg 900
cccaggaaga ctacgggagg ctacaccaac gtcaatcaga ggggcctgtg tagctaccga 960
taagcggacc ctcaagaggg cattagcaat agtgtttata aggccccctt gttaacccta 1020
aacgggtagc atatgcttcc cgggtagtag tatatactat ccagactaac cctaattcaa 1080
tagcatatgt tacccaacgg gaagcatatg ctatcgaatt agggttagta aaagggtcct 1140
aaggaacagc gatatctccc accccatgag ctgtcacggt tttatttaca tggggtcagg 1200
attccacgag ggtagtgaac cattttagtc acaagggcag tggctgaaga tcaaggagcg 1260
ggcagtgaac tctcctgaat cttcgcctgc ttcttcattc tccttcgttt agctaataga 1320
ataactgctg agttgtgaac agtaaggtgt atgtgaggtg ctcgaaaaca aggtttcagg 1380
tgacgccccc agaataaaat ttggacgggg ggttcagtgg tggcattgtg ctatgacacc 1440
aatataaccc tcacaaaccc cttgggcaat aaatactagt gtaggaatga aacattctga 1500
atatctttaa caatagaaat ccatggggtg gggacaagcc gtaaagactg gatgtccatc 1560
tcacacgaat ttatggctat gggcaacaca taatcctagt gcaatatgat actggggtta 1620
ttaagatgtg tcccaggcag ggaccaagac aggtgaacca tgttgttaca ctctatttgt 1680
aacaagggga aagagagtgg acgccgacag cagcggactc cactggttgt ctctaacacc 1740
cccgaaaatt aaacggggct ccacgccaat ggggcccata aacaaagaca agtggccact 1800
cttttttttg aaattgtgga gtgggggcac gcgtcagccc ccacacgccg ccctgcggtt 1860
ttggactgta aaataagggt gtaataactt ggctgattgt aaccccgcta accactgcgg 1920
tcaaaccact tgcccacaaa accactaatg gcaccccggg gaatacctgc ataagtaggt 1980
gggcgggcca agataggggc gcgattgctg cgatctggag gacaaattac acacacttgc 2040
gcctgagcgc caagcacagg gttgttggtc ctcatattca cgaggtcgct gagagcacgg 2100
tgggctaatg ttgccatggg tagcatatac tacccaaata tctggatagc atatgctatc 2160
ctaatctata tctgggtagc ataggctatc ctaatctata tctgggtagc atatgctatc 2220
ctaatctata tctgggtagt atatgctatc ctaatttata tctgggtagc ataggctatc 2280
ctaatctata tctgggtagc atatgctatc ctaatctata tctgggtagt atatgctatc 2340
ctaatctgta tccgggtagc atatgctatc ctaatagaga ttagggtagt atatgctatc 2400
ctaatttata tctgggtagc atatactacc caaatatctg gatagcatat gctatcctaa 2460
tctatatctg ggtagcatat gctatcctaa tctatatctg ggtagcatag gctatcctaa 2520
tctatatctg ggtagcatat gctatcctaa tctatatctg ggtagtatat gctatcctaa 2580
tttatatctg ggtagcatag gctatcctaa tctatatctg ggtagcatat gctatcctaa 2640
tctatatctg ggtagtatat gctatcctaa tctgtatccg ggtagcatat gctatcctca 2700
tgcatataca gtcagcatat gatacccagt agtagagtgg gagtgctatc ctttgcatat 2760
gccgccacct cccaaggggg cgtgaatttt cgctgcttgt ccttttcctg cggcgcgccg 2820
tttaaacatt taaatggatc cgcaccatat gcggtgtgaa ataccgcaca gatgcgtaag 2880
gagaaaatac cgcatcagat tggctattgg ccattgcata cgttgtatcc atatcataat 2940
atgtacattt atattggctc atgtccaaca ttaccgccat gttgacattg attattgact 3000
agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc 3060
gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg 3120
acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa 3180
tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca 3240
agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac 3300
atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc 3360
atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga 3420
tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg 3480
gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta 3540
cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc 3600
catccacgct gttttgacct ccatagaaga caccgggacc gatccagcct ccgcggccgg 3660
gaacggtgca ttggaacgcg gattccccgt gccaagagtg acgtaagtac cgcctataga 3720
gtctataggc ccaccccctt ggcttcttat gcatgctata ctgtttttgg cttggggtct 3780
atacaccccc gcttcctcat gttataggtg atggtatagc ttagcctata ggtgtgggtt 3840
attgaccatt attgaccact cccctattgg tgacgatact ttccattact aatccataac 3900
atggctcttt gccacaactc tctttattgg ctatatgcca atacactgtc cttcagagac 3960
tgacacggac tctgtatttt tacaggatgg ggtctcattt attatttaca aattcacata 4020
tacaacacca ccgtccccag tgcccgcagt ttttattaaa cataacgtgg gatctccacg 4080
cgaatctcgg gtacgtgttc cggacatggg ctcttctccg gtagcggcgg agcttctaca 4140
tccgagccct ggtcccatgc ctccagcggc tcatggtcgc tcggcagctc cttgctccta 4200
acagtggagg ccagacttag gcacagcaca atgcccacca ccaccagtgt gccgcacaag 4260
gccgtggcgg tagggtatgt gtctgaaaat gagcgtggag attgggctcg cacggctgac 4320
gcagatggaa gacttaaggc agcggcagaa gaagatgcag gcagctgagt tgttgtattc 4380
tgataagagt cagaggtaac tcccgttgcg gtgctgttaa cggtggaggg cagtgtagtc 4440
tgagcagtac tcgttgctgc cgcgcgcgcc accagacata atagctgaca gactaacaga 4500
ctgttccttt ccatgggtct tttctgcagt caccgtcctt gacacgaagc ttgccgccac 4560
catggaatgg agctgggtct ttctcttctt cctgtcagta actacaggtg tccactcgca 4620
ggtgcaattg gttcagagcg gcgcggaagt gaaaaaaccg ggcgaaagcc tgaaaattag 4680
ctgcaaaggt tccggatatt cctttactaa ttattggatt tcttgggtgc gccagatgcc 4740
tgggaagggt ctcgagtgga tgggcattat ctatccgggt gatagctata ccaattattc 4800
tccgagcttt cagggccagg tgaccattag cgcggataaa agcattagca ccgcgtatct 4860
tcaatggagc agcctgaaag cgagcgatac ggccatgtat tattgcgcgc gtgattattg 4920
gtataagcct ctttttgata tttggggcca aggcaccctg gtgacggtta gctcagcatc 4980
caccaagggc ccatccgtct tccccctggc gccctgctcc aggagcacct ccgagagcac 5040
agccgccctg ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa 5100
ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact 5160
ctactccctc agcagcgtgg tgaccgtgac ctccagcaac tttggcacgc agacctacac 5220
ctgcaacgta gatcacaagc ccagcaacac caaggtggac aagacagttg agcggaaatg 5280
ctgcgtggag tgcccaccat gcccagcacc tccagtggcc ggaccatcag tcttcctgtt 5340
ccccccaaaa cccaaggaca ctctcatgat ctcccggacc cctgaggtca cgtgcgtggt 5400
ggtggacgtg agccaggaag accccgaggt ccagttcaac tggtacgtgg atggcgtgga 5460
ggtgcataat gccaagacaa agccgcggga ggagcagttc aacagcacgt tccgtgtggt 5520
cagcgtcctc accgtcctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt 5580
ctccaacaaa ggcctcccgt cctccatcga gaaaaccatc tccaaaacca aagggcagcc 5640
ccgagagcca caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt 5700
cagcctgacc tgcctggtca aaggcttcta ccccagcgac atcgccgtgg agtgggagag 5760
caatgggcag ccggagaaca actacaagac cacgcctccc atgctggact ccgacggctc 5820
cttcttcctc tacagcaagc taaccgtgga caagagcagg tggcagcagg ggaatgtctt 5880
ctcatgctcc gtgatgcatg aggctctgca caaccactac acacagaaga gcctctccct 5940
gtctcctggt aaatgagcgg ccgcgatctg ctgtgccttc tagttgccag ccatctgttg 6000
tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct 6060
aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg 6120
gggtggggca gcacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg 6180
cggtgggctc tatggccgct gagatctggc cgctgcggcc aggtgctgaa gaattgaccc 6240
ggttcctcct gggccagaaa gaagcaggca catccccttc tctgtgacac accctgtcca 6300
cgcccctggt tcttagttcc agccccactc ataggacact catagctcag gagggctccg 6360
ccttcaatcc cacccgctaa agtacttgga gcggtctctc cctccctcat cagcccacca 6420
aaccaaacct agcctccaag agtgggaaga aattaaagca agataggcta ttaagtgcag 6480
agggagagaa aatgcctcca acatgtgagg aagtaatgag agaaatcata gaatttcttc 6540
cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc 6600
tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat 6660
gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt 6720
ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg 6780
aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc 6840
tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt 6900
ggcgctttct caatgctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa 6960
gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta 7020
tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa 7080
caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa 7140
ctacggctac actagaagga cagtatttgg tatctgcgct ctgctgaagc cagttacctt 7200
cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt 7260
ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat 7320
cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat 7380
gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc 7440
aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc 7500
acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc gggggggggg 7560
ggcgctgagg tctgcctcgt gaagaaggtg ttgctgactc ataccaggcc tgaatcgccc 7620
catcatccag ccagaaagtg agggagccac ggttgatgag agctttgttg taggtggacc 7680
agttggtgat tttgaacttt tgctttgcca cggaacggtc tgcgttgtcg ggaagatgcg 7740
tgatctgatc cttcaactca gcaaaagttc gatttattca acaaagccgc cgtcccgtca 7800
agtcagcgta atgctctgcc agtgttacaa ccaattaacc aattctgatt agaaaaactc 7860
atcgagcatc aaatgaaact gcaatttatt catatcagga ttatcaatac catatttttg 7920
aaaaagccgt ttctgtaatg aaggagaaaa ctcaccgagg cagttccata ggatggcaag 7980
atcctggtat cggtctgcga ttccgactcg tccaacatca atacaaccta ttaatttccc 8040
ctcgtcaaaa ataaggttat caagtgagaa atcaccatga gtgacgactg aatccggtga 8100
gaatggcaaa agcttatgca tttctttcca gacttgttca acaggccagc cattacgctc 8160
gtcatcaaaa tcactcgcat caaccaaacc gttattcatt cgtgattgcg cctgagcgag 8220
acgaaatacg cgatcgctgt taaaaggaca attacaaaca ggaatcgaat gcaaccggcg 8280
caggaacact gccagcgcat caacaatatt ttcacctgaa tcaggatatt cttctaatac 8340
ctggaatgct gttttcccgg ggatcgcagt ggtgagtaac catgcatcat caggagtacg 8400
gataaaatgc ttgatggtcg gaagaggcat aaattccgtc agccagttta gtctgaccat 8460
ctcatctgta acatcattgg caacgctacc tttgccatgt ttcagaaaca actctggcgc 8520
atcgggcttc ccatacaat                                              8539



<210> 36
<211> 9505
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1B20 IgG LC Plasmid

<400> 36
cgatagattg tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa 60
tcagcatcca tgttggaatt taatcgcggc ctcgagcaag acgtttcccg ttgaatatgg 120
ctcataacac cccttgtatt actgtttatg taagcagaca gttttattgt tcatgatgat 180
atatttttat cttgtgcaat gtaacatcag agattttgag acacaacgtg gctttccccc 240
cccccccatt attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa 300
tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct 360
gacgtctaag aaaccattat tatcatgaca ttaacctata aaaataggcg tatcacgagg 420
ccctttcgtc tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg 480
gagacggtca cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg 540
tcagcgggtg ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta 600
ctgagagtgc accatatgct taattaacgc ggggcagtgc atgtaatccc ttcagttggt 660
tggtacaact tgccaactgg gccctgttcc acatgtgaca cgggggggga ccaaacacaa 720
aggggttctc tgactgtagt tgacatcctt ataaatggat gtgcacattt gccaacactg 780
agtggctttc atcctggagc agactttgca gtctgtggac tgcaacacaa cattgccttt 840
atgtgtaact cttggctgaa gctcttacac caatgctggg ggacatgtac ctcccagggg 900
cccaggaaga ctacgggagg ctacaccaac gtcaatcaga ggggcctgtg tagctaccga 960
taagcggacc ctcaagaggg cattagcaat agtgtttata aggccccctt gttaacccta 1020
aacgggtagc atatgcttcc cgggtagtag tatatactat ccagactaac cctaattcaa 1080
tagcatatgt tacccaacgg gaagcatatg ctatcgaatt agggttagta aaagggtcct 1140
aaggaacagc gatatctccc accccatgag ctgtcacggt tttatttaca tggggtcagg 1200
attccacgag ggtagtgaac cattttagtc acaagggcag tggctgaaga tcaaggagcg 1260
ggcagtgaac tctcctgaat cttcgcctgc ttcttcattc tccttcgttt agctaataga 1320
ataactgctg agttgtgaac agtaaggtgt atgtgaggtg ctcgaaaaca aggtttcagg 1380
tgacgccccc agaataaaat ttggacgggg ggttcagtgg tggcattgtg ctatgacacc 1440
aatataaccc tcacaaaccc cttgggcaat aaatactagt gtaggaatga aacattctga 1500
atatctttaa caatagaaat ccatggggtg gggacaagcc gtaaagactg gatgtccatc 1560
tcacacgaat ttatggctat gggcaacaca taatcctagt gcaatatgat actggggtta 1620
ttaagatgtg tcccaggcag ggaccaagac aggtgaacca tgttgttaca ctctatttgt 1680
aacaagggga aagagagtgg acgccgacag cagcggactc cactggttgt ctctaacacc 1740
cccgaaaatt aaacggggct ccacgccaat ggggcccata aacaaagaca agtggccact 1800
cttttttttg aaattgtgga gtgggggcac gcgtcagccc ccacacgccg ccctgcggtt 1860
ttggactgta aaataagggt gtaataactt ggctgattgt aaccccgcta accactgcgg 1920
tcaaaccact tgcccacaaa accactaatg gcaccccggg gaatacctgc ataagtaggt 1980
gggcgggcca agataggggc gcgattgctg cgatctggag gacaaattac acacacttgc 2040
gcctgagcgc caagcacagg gttgttggtc ctcatattca cgaggtcgct gagagcacgg 2100
tgggctaatg ttgccatggg tagcatatac tacccaaata tctggatagc atatgctatc 2160
ctaatctata tctgggtagc ataggctatc ctaatctata tctgggtagc atatgctatc 2220
ctaatctata tctgggtagt atatgctatc ctaatttata tctgggtagc ataggctatc 2280
ctaatctata tctgggtagc atatgctatc ctaatctata tctgggtagt atatgctatc 2340
ctaatctgta tccgggtagc atatgctatc ctaatagaga ttagggtagt atatgctatc 2400
ctaatttata tctgggtagc atatactacc caaatatctg gatagcatat gctatcctaa 2460
tctatatctg ggtagcatat gctatcctaa tctatatctg ggtagcatag gctatcctaa 2520
tctatatctg ggtagcatat gctatcctaa tctatatctg ggtagtatat gctatcctaa 2580
tttatatctg ggtagcatag gctatcctaa tctatatctg ggtagcatat gctatcctaa 2640
tctatatctg ggtagtatat gctatcctaa tctgtatccg ggtagcatat gctatcctca 2700
tgcatataca gtcagcatat gatacccagt agtagagtgg gagtgctatc ctttgcatat 2760
gccgccacct cccaaggggg cgtgaatttt cgctgcttgt ccttttcctg cggcgcgccg 2820
tttaaacatt taaatggatc cgcaccatat gcggtgtgaa ataccgcaca gatgcgtaag 2880
gagaaaatac cgcatcagat tggctattgg ccattgcata cgttgtatcc atatcataat 2940
atgtacattt atattggctc atgtccaaca ttaccgccat gttgacattg attattgact 3000
agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc 3060
gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg 3120
acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa 3180
tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca 3240
agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac 3300
atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc 3360
atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga 3420
tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg 3480
gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta 3540
cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc 3600
catccacgct gttttgacct ccatagaaga caccgggacc gatccagcct ccgcggccgg 3660
gaacggtgca ttggaacgcg gattccccgt gccaagagtg acgtaagtac cgcctataga 3720
gtctataggc ccaccccctt ggcttcttat gcatgctata ctgtttttgg cttggggtct 3780
atacaccccc gcttcctcat gttataggtg atggtatagc ttagcctata ggtgtgggtt 3840
attgaccatt attgaccact cccctattgg tgacgatact ttccattact aatccataac 3900
atggctcttt gccacaactc tctttattgg ctatatgcca atacactgtc cttcagagac 3960
tgacacggac tctgtatttt tacaggatgg ggtctcattt attatttaca aattcacata 4020
tacaacacca ccgtccccag tgcccgcagt ttttattaaa cataacgtgg gatctccacg 4080
cgaatctcgg gtacgtgttc cggacatggg ctcttctccg gtagcggcgg agcttctaca 4140
tccgagccct gctcccatgc ctccagcgac tcatggtcgc tcggcagctc cttgctccta 4200
acagtggagg ccagacttag gcacagcacg atgcccacca ccaccagtgt gccgcacaag 4260
gccgtggcgg tagggtatgt gtctgaaaat gagcgtggag attgggctcg cacggctgac 4320
gcagatggaa gacttaaggc agcggcagaa gaagatgcag gcagctgagt tgttgtattc 4380
tgataagagt cagaggtaac tcccgttgcg gtgctgttaa cggtggaggg cagtgtagtc 4440
tgagcagtac tcgttgctgc cgcgcgcgcc accagacata atagctgaca gactaacaga 4500
ctgttccttt ccatgggtct tttctgcagt caccgtcctt gacacgaagc ttgccgccac 4560
catgagtgtg cccactcagg tcctggggtt gctgctgctg tggcttacag atgccagatg 4620
cgatatcgtg atgacccaga gcccggatag cctggcggtg agcctgggcg aacgtgcgac 4680
cattaactgc agaagcagcc agtctgttct ttattcttct aacaataaga attatctggc 4740
ttggtaccag cagaaaccag gtcagccgcc gaaactatta atttattggg cttctactcg 4800
tgaaagcggg gtcccggatc gttttagcgg ctctggatcc ggcactgatt ttaccctgac 4860
catttcgtcc ctgcaagctg aagacgtggc ggtgtattat tgccagcagt attcttcttt 4920
tcctattacc tttggccagg gtacgaaagt tgaaattaaa cgtacggtgg ctgcaccatc 4980
tgtcttcatc ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg 5040
cctgctgaat aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct 5100
ccaatcgggt aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag 5160
cctcagcagc accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg 5220
cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg 5280
ttaggcggcc gcgatctgct gtgccttcta gttgccagcc atctgttgtt tgcccctccc 5340
ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg 5400
aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagc 5460
acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta 5520
tggccgctga gatctggccg ctgcggccct gtggaatgtg tgtcagttag ggtgtggaaa 5580
gtccccaggc tccccagcag gcagaagtat gcaaagcatg catctcaatt agtcagcaac 5640
caggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca tgcatctcaa 5700
ttagtcagca accatagtcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag 5760
ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc 5820
cgcctctgcc tctgagctat tccagaagta gtgaggaggc ttttttggag gcctaggctt 5880
ttgcaaaaag ctgtcgacca ccatggccac ctcagcaagt tcccacttga acaaaaacat 5940
caagcaaatg tacttgtgcc tgccccaggg tgagaaagtc caagccatgt atatctgggt 6000
tgatggtact ggagaaggac tgcgctgcaa aacccgcacc ctggactgtg agcccaagtg 6060
tgtagaagag ttacctgagt ggaattttga tggctctagt acctttcagt ctgagggctc 6120
caacagtgac atgtatctca gccctgttgc catgtttcgg gaccccttcc gcagagatcc 6180
caacaagctg gtgttctgtg aagttttcaa gtacaaccgg aagcccgcag agaccaattt 6240
aaggcactcg tgtaaacgga taatggacat ggtgagcaac cagcacccct ggtttggaat 6300
ggaacaggag tatactctga tgggaacaga tgggcaccct tttggttggc cttccaatgg 6360
ctttcctgga ccccaaggtc cgtattactg tggtgtgggc gcagacaaag cctatggcag 6420
ggacatcgtg gaggctcact accgcgcctg cttgtatgct ggggtcaaga ttacaggaac 6480
aaatgctgag gtcatgcctg cccagtggga gttccaaata ggaccctgtg aaggaatccg 6540
catgggagat catctctggg tggcccgttt catcttgcat cgagtatgtg aagactttgg 6600
ggtaatagca acctttgacc ccaagcccat tcctgggaac tggaatggtg caggctgcca 6660
taccaacttt agcaccaagg ccatgcggga ggagaatggt ctgaagcaca tcgaggaggc 6720
catcgagaaa ctaagcaagc ggcaccggta tcacattcga gcctacgatc ccaagggggg 6780
cctggacaat gcccgtggtc tgactgggtt ccacgaaacg tccaacatca acgacttttc 6840
tgctggtgtc gccaatcgca gtgccagcat ccgcattccc cggactgtcg gccaggagaa 6900
gaaaggttac tttgaagacc gccgcccctc tgccaattgt gacccctttg cagtgacaga 6960
agccatcgtc cgcacatgcc ttctcaatga gactggcgac gagcccttcc aatacaaaaa 7020
ctaagtcgac aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac 7080
aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat 7140
caatgtatct tatcatgtct ggatcggcgc gccggccgct gcggccaggt gctgaagaat 7200
tgacccggtt cctcctgggc cagaaagaag caggcacatc cccttctctg tgacacaccc 7260
tgtccacgcc cctggttctt agttccagcc ccactcatag gacactcata gctcaggagg 7320
gctccgcctt caatcccacc cgctaaagta cttggagcgg tctctccctc cctcatcagc 7380
ccaccaaacc aaacctagcc tccaagagtg ggaagaaatt aaagcaagat aggctattaa 7440
gtgcagaggg agagaaaatg cctccaacat gtgaggaagt aatgagagaa atcatagaat 7500
ttcttccgct tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt 7560
atcagctcac tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa 7620
gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc 7680
gtttttccat aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag 7740
gtggcgaaac ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt 7800
gcgctctcct gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg 7860
aagcgtggcg ctttctcaat gctcacgctg taggtatctc agttcggtgt aggtcgttcg 7920
ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg 7980
taactatcgt cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac 8040
tggtaacagg attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg 8100
gcctaactac ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt 8160
taccttcgga aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg 8220
tggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc 8280
tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt 8340
ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt 8400
taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag 8460
tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccgggg 8520
ggggggggcg ctgaggtctg cctcgtgaag aaggtgttgc tgactcatac caggcctgaa 8580
tcgccccatc atccagccag aaagtgaggg agccacggtt gatgagagct ttgttgtagg 8640
tggaccagtt ggtgattttg aacttttgct ttgccacgga acggtctgcg ttgtcgggaa 8700
gatgcgtgat ctgatccttc aactcagcaa aagttcgatt tattcaacaa agccgccgtc 8760
ccgtcaagtc agcgtaatgc tctgccagtg ttacaaccaa ttaaccaatt ctgattagaa 8820
aaactcatcg agcatcaaat gaaactgcaa tttattcata tcaggattat caataccata 8880
tttttgaaaa agccgtttct gtaatgaagg agaaaactca ccgaggcagt tccataggat 8940
ggcaagatcc tggtatcggt ctgcgattcc gactcgtcca acatcaatac aacctattaa 9000
tttcccctcg tcaaaaataa ggttatcaag tgagaaatca ccatgagtga cgactgaatc 9060
cggtgagaat ggcaaaagct tatgcatttc tttccagact tgttcaacag gccagccatt 9120
acgctcgtca tcaaaatcac tcgcatcaac caaaccgtta ttcattcgtg attgcgcctg 9180
agcgagacga aatacgcgat cgctgttaaa aggacaatta caaacaggaa tcgaatgcaa 9240
ccggcgcagg aacactgcca gcgcatcaac aatattttca cctgaatcag gatattcttc 9300
taatacctgg aatgctgttt tcccggggat cgcagtggtg agtaaccatg catcatcagg 9360
agtacggata aaatgcttga tggtcggaag aggcataaat tccgtcagcc agtttagtct 9420
gaccatctca tctgtaacat cattggcaac gctacctttg ccatgtttca gaaacaactc 9480
tggcgcatcg ggcttcccat acaat                                       9505



<210> 37
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 Antibody Variant VH CDR1 Sequence

<221> VARIANT        
<222> 6
<223> Xaa = Asn or Asp

<221> VARIANT        
<222> 8
<223> Xaa = Trp or Tyr

<221> VARIANT        
<222> 10
<223> Xaa  = Ser, Thr or Ala

<400> 37
Gly Tyr Ser Phe Thr Xaa Tyr Xaa Ile Xaa
 1               5                  10  


<210> 38
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 Antibody Variant VH CDR2 Sequence

<221> VARIANT        
<222> 4
<223> Xaa = Ile, Arg, Trp, Leu, or Met

<221> VARIANT        
<222> 11
<223> Xaa = Tyr or Asp

<221> VARIANT        
<222> 13
<223> Xaa = Asn, Arg, His, Ser, Lys or Gln

<221> VARIANT        
<222> 15
<223> Xaa = Ser or Asn

<221> VARIANT        
<222> 16
<223> Xaa = Pro, Gln, or His

<221> VARIANT        
<222> (17)...(17)
<223> Xaa = Ser, Lys, Asn or Arg

<400> 38
Trp Met Gly Xaa Ile Tyr Pro Gly Asp Ser Xaa Thr Xaa Tyr Xaa Xaa
 1               5                  10                  15      
Xaa Phe Gln Gly
            20  


<210> 39
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 Antibody Variant VH CDR3 Sequence

<221> VARIANT        
<222> 2
<223> Xaa = Tyr, Arg or His

<221> VARIANT        
<222> 3
<223> Xaa = Trp, Tyr, Gly, Ala or Phe

<221> VARIANT        
<222> 4
<223> Xaa = Tyr or Ser

<221> VARIANT        
<222> 5
<223> Xaa = Lys, Arg, Thr, Gly, Ser, Asp, Glu, His, Asn
      or Gln

<221> VARIANT        
<222> 6
<223> Xaa = Pro, Ser, Gly, Asp, Ala, His, Arg or Tyr

<221> VARIANT        
<222> (7)...(7)
<223> xaa = Leu, Tyr, Phe, Ala, Asp, His, Pro, Ser or
      Val

<221> VARIANT        
<222> (8)...(8)
<223> xaa = Phe or Ser

<221> VARIANT        
<222> (10)...(10)
<223> xaa = Ile, Val, Tyr, Phe or Asn

<400> 39
Asp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa
 1               5                  10  


<210> 40
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 Antibody Variant VL CDR1 Sequence

<221> VARIANT        
<222> 1
<223> Xaa = Arg, Lys, His, Asn, Gln or Ser

<221> VARIANT        
<222> 7
<223> Xaa = Leu or Phe

<221> VARIANT        
<222> 8
<223> Xaa = Tyr or His

<221> VARIANT        
<222> 10
<223> Xaa = Ser, Arg or Gly

<221> VARIANT        
<222> 11
<223> Xaa = Asn or Thr

<221> VARIANT        
<222> (12)...(12)
<223> xaa = Asn, Arg, His or Ser

<221> VARIANT        
<222> (15)...(15)
<223> xaa = Tyr or Phe

<221> VARIANT        
<222> (17)...(17)
<223> xaa = Ala or Thr

<400> 40
Xaa Ser Ser Gln Ser Val Xaa Xaa Ser Xaa Xaa Xaa Lys Asn Xaa Leu
 1               5                  10                  15      
Xaa
    


<210> 41
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 Antibody Variant VL CDR2 Sequence

<221> VARIANT        
<222> 5
<223> Xaa = Trp, Phe or Leu

<221> VARIANT        
<222> 6
<223> Xaa = Ala or Thr

<221> VARIANT        
<222> 8
<223> Xaa = Thr, Ile, Ala or Val

<221> VARIANT        
<222> 10
<223> Xaa = Glu, Ala or Lys

<221> VARIANT        
<222> 11
<223> Xaa = Ser or Thr

<400> 41
Leu Leu Ile Tyr Xaa Xaa Ser Xaa Arg Xaa Xaa
 1               5                  10      


<210> 42
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 Antibody Variant VL CDR3 Sequence

<221> VARIANT        
<222> 4
<223> Xaa = Ser or Tyr

<221> VARIANT        
<222> 5
<223> Xaa = Ser or Thr

<221> VARIANT        
<222> 6
<223> Xaa = Phe, Tyr, Leu, Thr, His, Ile, Asn, Pro or
      Ser

<221> VARIANT        
<222> 8
<223> Xaa = Ile, Arg, Val, Tyr, Asp, Phe, Gly, His, Leu,
      Asn or Ser

<400> 42
Gln Gln Tyr Xaa Xaa Xaa Pro Xaa
 1               5              


<210> 43
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL; 1B20 Variant Sequence

<221> VARIANT        
<222> 24
<223> Xaa = Arg, Lys, His, Asn, Gln or Ser

<221> VARIANT        
<222> 30
<223> Xaa = Leu or Phe

<221> VARIANT        
<222> 31
<223> Xaa = Tyr or His

<221> VARIANT        
<222> 33
<223> Xaa = ser, Arg or Gly

<221> VARIANT        
<222> 34
<223> Xaa = Asn or Thr

<221> VARIANT        
<222> (35)...(35)
<223> Xaa = Asn, Arg, His or Ser

<221> VARIANT        
<222> (38)...(38)
<223> Xaa = Tyr or Phe

<221> VARIANT        
<222> (40)...(40)
<223> Xaa = Ala or Thr

<221> VARIANT        
<222> (56)...(56)
<223> Xaa = Trp, Phe or Leu

<221> VARIANT        
<222> (57)...(57)
<223> Xaa = Ala or Thr

<221> VARIANT        
<222> (59)...(59)
<223> Xaa = Thr, Ile, Ala or Val

<221> VARIANT        
<222> (61)...(61)
<223> Xaa = Glu, Ala or Lys

<221> VARIANT        
<222> (62)...(62)
<223> Xaa = Ser or Thr

<221> VARIANT        
<222> (98)...(98)
<223> Xaa = Ser or Tyr

<221> VARIANT        
<222> (99)...(99)
<223> Xaa = Ser or Thr

<221> VARIANT        
<222> (100)...(100)
<223> Xaa = Phe, Tyr, Leu, Thr, His, Ile, Asn, Pro or
      Ser

<221> VARIANT        
<222> (102)...(102)
<223> Xaa = Ile, Arg, Val, Tyr, Asp, Phe, Gly, His, Leu,
      Asn or Ser

<400> 43
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Xaa Ser Ser Gln Ser Val Xaa Xaa Ser
            20                  25                  30          
Xaa Xaa Xaa Lys Asn Xaa Leu Xaa Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Xaa Xaa Ser Xaa Arg Xaa Xaa Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Xaa Xaa Xaa Pro Xaa Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
            100                 105                 110         
Lys Arg
        


<210> 44
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence

<221> VARIANT        
<222> 31
<223> Xaa = Asn or Asp

<221> VARIANT        
<222> 33
<223> Xaa = Trp or Tyr

<221> VARIANT        
<222> 35
<223> Xaa = Ser, Thr or Ala

<221> VARIANT        
<222> 50
<223> Xaa = Ile, Arg, Trp, Leu or Met

<221> VARIANT        
<222> 57
<223> Xaa = Tyr or Asp

<221> VARIANT        
<222> (59)...(59)
<223> Xaa = Asn, Arg, His, Ser, Lys or Gln

<221> VARIANT        
<222> (61)...(61)
<223> Xaa = Ser or Asn

<221> VARIANT        
<222> (62)...(62)
<223> Xaa = Pro, Gln or His

<221> VARIANT        
<222> (63)...(63)
<223> Xaa = Ser, Lys, Asn or Arg

<221> VARIANT        
<222> (100)...(100)
<223> Xaa = Tyr, Arg or His

<221> VARIANT        
<222> (101)...(101)
<223> Xaa = Trp, Tyr or Gly

<221> VARIANT        
<222> (102)...(102)
<223> Xaa = Tyr or Ser

<221> VARIANT        
<222> (103)...(103)
<223> Xaa = Lys, Arg, Thr, Gly, Ser, Asp, Glu, His, Asn
      or Gln

<221> VARIANT        
<222> (104)...(104)
<223> Xaa = Pro, Ser, Gly, Asp, Ala, His, Arg or Tyr

<221> VARIANT        
<222> (105)...(105)
<223> Xaa = Leu, Tyr, Phe, Ala, Asp, His, Pro, Ser or
      Val

<221> VARIANT        
<222> (106)...(106)
<223> Xaa = Phe or Ser

<221> VARIANT        
<222> (108)...(108)
<223> Xaa = Ile, Val, Tyr, Phe or Asn

<400> 44
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Xaa Tyr
            20                  25                  30          
Xaa Ile Xaa Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Xaa Ile Tyr Pro Gly Asp Ser Xaa Thr Xaa Tyr Xaa Xaa Xaa Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 45
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence F120

<400> 45
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Leu Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Asn Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Tyr Ser Arg Pro Phe Ser Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 46
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence F116

<400> 46
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Leu Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Asn Pro Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Tyr Ser Arg Pro Tyr Ser Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 47
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence F119

<400> 47
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Leu Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Ser Pro Asn Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Gly Tyr Arg Pro Tyr Ser Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 48
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence F113

<400> 48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Leu Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Asn Pro Asn Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Tyr Ser Thr Pro Phe Phe Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 49
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence E2

<400> 49
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Leu Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Asn Arg Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Tyr Ser Arg Pro Leu Ser Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 50
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence G4

<400> 50
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Leu Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Ser Pro Arg Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Gly Tyr Lys Pro Tyr Ser Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 51
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence F4

<400> 51
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Leu Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Tyr Ser Lys Pro Leu Phe Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 52
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence B9

<400> 52
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Ile His Tyr Asn Gln Asn Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Tyr Ser Arg Pro Phe Ser Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 53
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence C3

<400> 53
Gln Val Lys Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Asn Pro Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Gly Tyr Lys Pro Phe Ser Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 54
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence F2

<400> 54
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Asn Pro Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Ser Arg Pro Tyr Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 55
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence F7

<400> 55
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Asn Pro Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Ser Arg Pro Phe Ser Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 56
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence A7

<400> 56
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Asn Pro Asn Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Ser Lys Pro Leu Ser Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 57
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence G8

<400> 57
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Leu Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Asn Pro Asn Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Ser Lys Pro Tyr Phe Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 58
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence H4

<400> 58
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Thr Trp Val Arg Gln Met Pro Gly Arg Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Asn Pro Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Ser Lys Pro Phe Ser Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 59
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence D5

<400> 59
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Thr Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Leu Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Ser Pro Arg Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Ser Arg Pro Tyr Ser Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 60
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence D4

<400> 60
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Asn Pro Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Ser Arg Pro Phe Ser Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 61
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence B4

<400> 61
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Leu Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Asn Pro Asn Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Ser Lys Pro Leu Phe Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 62
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence H1

<400> 62
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Asn Pro Arg Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Ser Lys Pro Leu Ser Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 63
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence G2

<400> 63
Gln Val Lys Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Asn Pro Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Arg Trp Ser Lys Pro Leu Phe Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 64
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence A1

<400> 64
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Leu Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Asn Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Ser Lys Pro Leu Ser Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 65
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence A4

<400> 65
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ser Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Ser His Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Ser Arg Pro Phe Phe Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 66
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence C2

<400> 66
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Leu Ile Tyr Pro Gly Asp Ser Tyr Thr Ser Tyr Asn Pro Arg Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Ser Thr Pro Tyr Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 67
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence H5

<400> 67
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr Ser Tyr Ser Pro Arg Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Ser Arg Pro Leu Phe Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 68
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence F6

<400> 68
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Leu Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Asn Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Tyr Lys Pro Phe Ser Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 69
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence B6

<400> 69
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Asn Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Tyr Arg Pro Phe Ser Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 70
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence B1

<400> 70
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Ser Pro Asn Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Tyr Thr Pro Phe Phe Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 71
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence F1

<400> 71
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Leu Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Ser Lys Pro Leu Ser Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 72
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence A8

<400> 72
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Ser Pro Asn Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Ser Lys Pro Tyr Phe Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 73
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence B3

<400> 73
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr Ser Tyr Asn Pro Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Ser Lys Pro Tyr Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 74
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence F8

<400> 74
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Ser Arg Pro Tyr Ser Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 75
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence H8

<400> 75
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Ser Gln Asn Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Ser Arg Pro Phe Phe Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 76
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence B5

<400> 76
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Ser Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Tyr Lys Pro Phe Ser Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 77
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence E1

<400> 77
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr Ser Tyr Asn Pro Asn Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Ser Lys Pro Phe Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 78
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence E8

<400> 78
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Thr Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Ser Pro Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Ser Lys Pro Leu Ser Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 79
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence C1

<400> 79
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Ser Pro Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Tyr Arg Pro Tyr Ser Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 80
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence H3

<400> 80
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Thr Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Ser Gln Arg Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Ser Arg Pro Leu Phe Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 81
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence A9

<400> 81
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Ser Pro Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Tyr Arg Pro Tyr Ser Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 82
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence G7

<400> 82
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Ser Lys Pro Tyr Phe Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 83
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence C6

<400> 83
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Thr Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Asn Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Tyr Lys Pro Leu Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 84
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence G6

<400> 84
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Asn Pro Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Ser Arg Pro Phe Ser Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 85
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence E4

<400> 85
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Ser Tyr Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Ser Lys Pro Tyr Ser Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 86
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence F5

<400> 86
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Thr Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Arg His Asn Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Ser Arg Pro Tyr Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 87
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence C7

<400> 87
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Ser His Asn Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Ser Arg Pro Phe Ser Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 88
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence E3

<400> 88
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr Ser Tyr Ser Pro Arg Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Tyr Arg Pro Phe Ser Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 89
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence D3

<400> 89
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Thr Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Ser Pro Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Ser Lys Pro Phe Phe Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 90
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence D8

<400> 90
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Ser Gln Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Tyr Arg Pro Leu Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 91
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence C8

<400> 91
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr Ser Tyr Ser His Arg Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Tyr Arg Pro Tyr Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 92
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence E5

<400> 92
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Asn Pro Asn Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Arg Trp Ser Thr Pro Tyr Phe Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 93
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence B8

<400> 93
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Ser Pro Asn Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Ser Lys Pro Tyr Phe Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 94
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence H7

<400> 94
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Pro Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Ser Gln Lys Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Ser Arg Pro Leu Ser Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 95
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence A5

<400> 95
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Ser Tyr Thr His Tyr Asn Pro Met Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Arg Trp Ser Arg Pro Tyr Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 96
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 Variant Sequence A3

<400> 96
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Ser Pro Asn Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp His Trp Tyr Arg Pro Leu Ser Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 97
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 Antibody Variant VH CDR2 Sequence

<221> VARIANT        
<222> 4
<223> Xaa = Ile or Arg

<221> VARIANT        
<222> 13
<223> Xaa = Asn, Arg, His or Ser

<221> VARIANT        
<222> 16
<223> Xaa = Pro or Gln

<400> 97
Trp Met Gly Xaa Ile Tyr Pro Gly Asp Ser Tyr Thr Xaa Tyr Ser Xaa
 1               5                  10                  15      
Ser Phe Gln Gly
            20  


<210> 98
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 Antibody Variant VH CDR3 Sequence

<221> VARIANT        
<222> 5
<223> Xaa = Lys, Gly, Arg, Ser, Asp, Glu, His, Asn or
      Gln

<221> VARIANT        
<222> 6
<223> Xaa = Pro, Gly, Asp, Ser, Ala, His, Arg or Tyr

<221> VARIANT        
<222> 7
<223> Xaa = Leu, Ala, Tyr, Asp, Phe, His, Pro, Ser or
      Val

<221> VARIANT        
<222> 10
<223> Xaa = Ile, Tyr, Phe or Asn

<400> 98
Asp Tyr Trp Tyr Xaa Xaa Xaa Phe Asp Xaa
 1               5                  10  


<210> 99
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 Antibody Variant VL CDR1 Sequence

<221> VARIANT        
<222> 15
<223> Xaa = Tyr or Phe

<221> VARIANT        
<222> 17
<223> Xaa = Ala or Thr

<400> 99
Arg Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Xaa Leu
 1               5                  10                  15      
Xaa
    


<210> 100
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 Antibody Variant VL CDR2 Sequence

<221> VARIANT        
<222> 5
<223> Xaa = Trp, Phe or Leu

<221> VARIANT        
<222> 10
<223> Xaa = Glu or Lys

<221> VARIANT        
<222> 11
<223> Xaa = Ser or Thr

<400> 100
Leu Leu Ile Tyr Xaa Ala Ser Thr Arg Xaa Xaa
 1               5                  10      


<210> 101
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 Antibody Variant VL CDR3 Sequence

<221> VARIANT        
<222> 6
<223> Xaa = Phe, Tyr, Thr, Ile, Asn or Ser

<221> VARIANT        
<222> 8
<223> Xaa = Ile, Tyr, Arg, Phe, His, Leu, Asn or Ser

<400> 101
Gln Gln Tyr Ser Ser Xaa Pro Xaa
 1               5              


<210> 102
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 Antibody Variant VH Sequence N59K

<400> 102
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr Lys Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Tyr Lys Pro Leu Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 103
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 Antibody Variant VH Sequence N59Q

<400> 103
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr Gln Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Tyr Lys Pro Leu Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 104
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 Antibody Variant VH Sequence N59R

<400> 104
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr Arg Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Tyr Lys Pro Leu Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 105
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 Antibody Variant VH Sequence W101A

<400> 105
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Ala Tyr Lys Pro Leu Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 106
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 Antibody Variant VH Sequence W101F

<400> 106
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Phe Tyr Lys Pro Leu Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 107
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1B20 Antibody Variant VH Sequence W101Y

<400> 107
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30          
Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Tyr Tyr Lys Pro Leu Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 108
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL; 1B20 VARIANT SEQUENCE

<221> VARIANT        
<222> 38
<223> Xaa = Tyr or Phe

<221> VARIANT        
<222> 40
<223> Xaa = Ala or Thr

<221> VARIANT        
<222> 56
<223> Xaa = Trp, Phe or Leu

<221> VARIANT        
<222> 61
<223> Xaa = Glu or Lys

<221> VARIANT        
<222> 62
<223> Xaa = Ser or Thr

<221> VARIANT        
<222> (100)...(100)
<223> Xaa = Phe, Tyr, Thr, Ile, Asn or Ser

<221> VARIANT        
<222> (102)...(102)
<223> Xaa = Ile, Tyr, Arg, Phe, His, Leu, Asn or Ser

<400> 108
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Asn Lys Asn Xaa Leu Xaa Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Xaa Ala Ser Thr Arg Xaa Xaa Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Ser Ser Xaa Pro Xaa Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
            100                 105                 110         
Lys Arg
        


<210> 109
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1B20 VARIANT SEQUENCE

<221> VARIANT        
<222> 31
<223> Xaa = Asn or Asp

<221> VARIANT        
<222> 33
<223> Xaa = Trp or Tyr

<221> VARIANT        
<222> 35
<223> Xaa = Ser, Thr or Ala

<221> VARIANT        
<222> 50
<223> Xaa = Ile or Arg

<221> VARIANT        
<222> 59
<223> Xaa = Asn, Arg, His, Ser, Lys or Gln

<221> VARIANT        
<222> (62)...(62)
<223> Xaa = Pro or Gln

<221> VARIANT        
<222> (103)...(103)
<223> Xaa = Lys, Gly, Arg, Ser, Asp, Glu, His, Asn or
      Gln

<221> VARIANT        
<222> (104)...(104)
<223> Xaa = Pro, Gly, Asp, Ser, Ala, His, Arg or Tyr

<221> VARIANT        
<222> (105)...(105)
<223> Xaa = Leu, Ala, Tyr, Asp, Phe, His, Pro, Ser or
      Val

<221> VARIANT        
<222> (108)...(108)
<223> Xaa = Ile, Tyr, Phe or Asn

<400> 109
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Xaa Tyr
            20                  25                  30          
Xaa Ile Xaa Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Xaa Ile Tyr Pro Gly Asp Ser Tyr Thr Xaa Tyr Ser Xaa Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Tyr Trp Tyr Xaa Xaa Xaa Phe Asp Xaa Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 

