                         SEQUENCE LISTING

<110>  MedImmune LLC.
 
<120>  Anti-IFNAR1 antibodies with reduced Fc ligand affinity

<130>  IA161PCT

<150>  US 61/006,962
<151>  2008-02-08

<150>  US 61/034,618
<151>  2008-03-07

<150>  US 61/049,970
<151>  2008-05-02

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  1

Arg Ala Ser Gln Gly Ile Tyr Ser Val Leu Ala 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  2

Asp Ala Ser Arg Leu Glu Ser 
1               5           


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3

Gln Gln Phe Asn Ser Tyr Ile Thr 
1               5               


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  4

Gly Tyr Phe Trp Ser 
1               5   


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5

Glu Ile Asp His Ser Gly Lys Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  6

Glu Ser Lys Tyr Tyr Phe Gly Leu Asp Val 
1               5                   10  


<210>  7
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  7
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttctgagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt ggttatttct ggagctggat ccgccagccc      120

ccagggaagg ggctggagtg gattggggaa atcgatcaca gtggaaagac caactacaat      180

ccgtccctca agagtcgagt taccatatca gtagacacgt ccaagaacca ggtctccctg      240

aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag agaaagcaag      300

tactacttcg gtttggacgt ctggggccaa gggaccacgg tcaccgtcac ctca            354


<210>  8
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Phe Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp His Ser Gly Lys Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Ser Lys Tyr Tyr Phe Gly Leu Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Thr Ser 
        115             


<210>  9
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  9
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcatttac agtgttttag cctggtatca gcagaaacca      120

gggaaaactc ctaagctcct gatctatgat gcctcccgtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt acatcacctt cggccaaggg      300

acacgactgg agattaaa                                                    318


<210>  10
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  10

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Tyr Ser Val 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Ile Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105     


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  11

Arg Ala Thr Gln Asp Ile Ser Ile Ala Leu Val 
1               5                   10      


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  12

Asp Ala Ser Gly Leu Gly Ser 
1               5           


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  13

Gln Gln Phe Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  14

Asn Tyr Tyr Trp Ser 
1               5   


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  15

Glu Ile Ile Leu Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  16

Glu Ser Lys Trp Gly Tyr Tyr Phe Asp Ser 
1               5                   10  


<210>  17
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  17
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt aattactact ggagctggat ccgccagccc      120

ccagggaagg ggctggagtg gattggggaa atcattctta gtggaagcac caactacaac      180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aacctgacct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag agagtctaaa      300

tggggttact actttgactc ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  18
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  18

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Ile Leu Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Ser Lys Trp Gly Tyr Tyr Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  19
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  19
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaactca ggacattagc attgctttag tctggtatca gcagaaacca      120

gggaaagctc ctgagctcct gatctatgat gcctccggtt tgggaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tggcacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa a                                                321


<210>  20
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  20

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Asp Ile Ser Ile Ala 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Gly Leu Gly Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  21

Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Phe Ala 
1               5                   10          


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  22

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  23

Gln Gln Tyr Tyr Asp Ser Ser Ala Ile Thr 
1               5                   10  


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  24

Asn Tyr Trp Ile Ala 
1               5   


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  25

Ile Ile Tyr Pro Gly Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  26

His Asp Ile Glu Gly Phe Asp Tyr 
1               5               


<210>  27
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  27
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata catctttacc aattactgga tcgcctgggt gcgccagatg      120

cccggtaaag gcctggagtc gatggggatc atctatcctg gtgactctga tatcagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcac caccgcctac      240

ctgcagtgga gcagtctgaa ggcctcagac accgccatgt attactgtgc gagacatgac      300

atagaggggt ttgactactg gggccgggga accctggtca ccgtctcctc a               351


<210>  28
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  28

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Ser Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Ile Glu Gly Phe Asp Tyr Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  29
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  29
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagcttct tcgcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttaa gtggcagtgg gtctgggaca gacttcactc tcaccatcac cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatgata gctcagcgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  30
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  30

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Phe Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Ala 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  31

Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Phe Ala 
1               5                   10          


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  32

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  33

Gln Gln Tyr Asp Ser Ser Ala Ile Thr 
1               5                   


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  34

Asn Tyr Trp Ile Ala 
1               5   


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  35

Ile Ile Tyr Pro Gly Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  36

His Asp Ile Glu Gly Phe Asp Tyr 
1               5               


<210>  37
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  37
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata catctttacc aactactgga tcgcctgggt gcgccagatg      120

cccggtaaag gcctggagtc gatggggatc atctatcctg gtgactctga tatcagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcac caccgcctac      240

ctgcagtgga gcagtctgaa ggcctcagac accgccatgt attactgtgc gagacatgac      300

atagaggggt ttgactactg gggccgggga accctggtca ccgtctcctc a               351


<210>  38
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  38

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Ser Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Ile Glu Gly Phe Asp Tyr Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  39
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  39
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagcttct tcgcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttaa gtggcagtgg gtctgggaca gacttcactc tcaccatcac cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatgata gctcagcgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  40
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  40

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Phe Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Leu Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Ala 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  41
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  41

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  42
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  42

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  43
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  43
cgtgcccagc acctgaattc gaggggggac cgtcagtctt c                           41


<210>  44
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  44
gaagactgac ggtcccccct cgaattcagg tgctgggcac g                           41


<210>  45
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  45
ccaacaaagc cctcccagcc tccatcgaga aaaccatctc c                           41


<210>  46
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  46
ggagatggtt ttctcgatgg aggctgggag ggctttgttg g                           41


<210>  47
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  47
ggtcccccat gcccaccatg cccagcacct g                                      31


<210>  48
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  48
caggtgctgg gcatggtggg catgggggac c                                      31


<210>  49
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  49
ccagcacctg agttcgaggg gggaccatca gtc                                    33


<210>  50
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  50
gactgatggt cccccctcga actcaggtgc tgg                                    33


