
                                SEQUENCE LISTING

<110> Merck & Co., Inc.
      Condra, Jon H.
      Cubbon, Rose M.
      Hammond, Holly A.
      Orsatti, Laura
      Pandit, Shilpa
      Peterson, Laurence B.
      Santoro, Joseph C.
      Sitlani, Ayesha
      Wood, Dana D.

<120> 1D05 PCSK9 ANTAGONISTS
  

<130> MRL-ACV-22542

<150> 61/063,949          
<151> 2008-02-07  

<150> 61/066,577          
<151> 2008-02-21  

<160> 60

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC; m2CX1D05

<400> 1
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Ser Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asn Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Asp Gly Asp Pro Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205             
Asn Arg Gly Glu Ala
    210             


<210> 2
<211> 639
<212> DNA
<213> Artificial Sequence

<220> 
<223> LC; m2CX1D05

<400> 2
gatatccaga tgacccagag cccgtctagc ctgagcgcga gcgtgggtga tcgtgtgacc 60
attacctgca gagcgagcca gggtattcgt tctgctctga attggtacca gcagaaacca 120
ggtaaagcac cgaaactatt aatttataat ggttctactt tgcaaagcgg ggtcccgtcc 180
cgttttagcg gctctggatc cggcactgat tttaccctga ccattagcag cctgcaacct 240
gaagactttg cggtttatta ttgccagcag tttgatggtg atcctacctt tggccagggt 300
acgaaagttg aaattaaacg tacggtggct gctccgagcg tgtttatttt tccgccgagc 360
gatgaacaac tgaaaagcgg cacggcgagc gtggtgtgcc tgctgaacaa cttttatccg 420
cgtgaagcga aagttcagtg gaaagtagac aacgcgctgc aaagcggcaa cagccaggaa 480
agcgtgaccg aacaggatag caaagatagc acctattctc tgagcagcac cctgaccctg 540
agcaaagcgg attatgaaaa acataaagtg tatgcgtgcg aagtgaccca tcaaggtctg 600
agcagcccgg tgactaaatc ttttaatcgt ggcgaggcc                        639

<210> 3
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR 1; m2CX1D05

<400> 3
Arg Ala Ser Gln Gly Ile Arg Ser Ala Leu Asn
 1               5                  10      


<210> 4
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> VL CDR 1; m2CX1D05

<400> 4
agagcgagcc agggtattcg ttctgctctg aat                              33

<210> 5
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR2; m2CX1D05

<400> 5
Leu Leu Ile Tyr Asn Gly Ser Thr Leu Gln Ser
 1               5                  10      


<210> 6
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> VL CDR2; m2CX1D05

<400> 6
ctattaattt ataatggttc tactttgcaa agc                              33

<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR3; m2CX1D05

<400> 7
Gln Gln Phe Asp Gly Asp Pro
 1               5          


<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> VL CDR3; m2CX1D05

<400> 8
cagcagtttg atggtgatcc t                                           21

<210> 9
<211> 255
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fd CHAIN; m2CX1D05

<400> 9
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser His
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Asn Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Tyr Glu Ile Gln Ile Gly Arg Tyr Gly Met Asn Val Tyr
            100                 105                 110         
Tyr Leu Met Tyr Arg Phe Ala Ser Trp Gly Gln Gly Thr Leu Val Thr
        115                 120                 125             
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
    130                 135                 140                 
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val
145                 150                 155                 160 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                165                 170                 175     
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
            180                 185                 190         
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly
        195                 200                 205             
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
    210                 215                 220                 
Val Asp Lys Lys Val Glu Pro Lys Ser Glu Phe Glu Gln Lys Leu Ile
225                 230                 235                 240 
Ser Glu Glu Asp Leu Asn Gly Ala Pro His His His His His His
                245                 250                 255 


<210> 10
<211> 765
<212> DNA
<213> Artificial Sequence

<220> 
<223> Fd CHAIN; m2CX1D05

<400> 10
caggtgcaat tggttcagtc tggcgcggaa gtgaaaaaac cgggcagcag cgtgaaagtg 60
agctgcaaag cctccggagg cacttttaat tctcatgcta tttcttgggt gcgccaagcc 120
cctgggcagg gtctcgagtg gatgggcggt atcaatccga ttcttggcat tgcgaattac 180
gcgcagaagt ttcagggccg ggtgaccatt accgcggatg aaagcaccag caccgcgtat 240
atggaactga gcagcctgcg tagcgaagat acggccgtgt attattgcgc gcgtcattat 300
gagattcaga ttggtcgtta tggtatgaat gtttattatc ttatgtatcg ttttgcttct 360
tggggccaag gcaccctggt gacggttagc tcagcgtcga ccaaaggtcc aagcgtgttt 420
ccgctggctc cgagcagcaa aagcaccagc ggcggcacgg ctgccctggg ctgcctggtt 480
aaagattatt tcccggaacc agtcaccgtg agctggaaca gcggggcgct gaccagcggc 540
gtgcatacct ttccggcggt gctgcaaagc agcggcctgt atagcctgag cagcgttgtg 600
accgtgccga gcagcagctt aggcactcag acctatattt gcaacgtgaa ccataaaccg 660
agcaacacca aagtggataa aaaagtggaa ccgaaaagcg aattcgagca gaagctgatc 720
tctgaggagg atctgaacgg cgcgccgcac catcatcacc atcac                 765

<210> 11
<211> 131
<212> PRT
<213> Artifical Sequence

<220> 
<223> VH; m2CX1D05

<400> 11
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser His
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Asn Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Tyr Glu Ile Gln Ile Gly Arg Tyr Gly Met Asn Val Tyr
            100                 105                 110         
Tyr Leu Met Tyr Arg Phe Ala Ser Trp Gly Gln Gly Thr Leu Val Thr
        115                 120                 125             
Val Ser Ser
    130     


<210> 12
<211> 393
<212> DNA
<213> Artificial Sequence

<220> 
<223> VH; m2CX1D05

<400> 12
caggtgcaat tggttcagtc tggcgcggaa gtgaaaaaac cgggcagcag cgtgaaagtg 60
agctgcaaag cctccggagg cacttttaat tctcatgcta tttcttgggt gcgccaagcc 120
cctgggcagg gtctcgagtg gatgggcggt atcaatccga ttcttggcat tgcgaattac 180
gcgcagaagt ttcagggccg ggtgaccatt accgcggatg aaagcaccag caccgcgtat 240
atggaactga gcagcctgcg tagcgaagat acggccgtgt attattgcgc gcgtcattat 300
gagattcaga ttggtcgtta tggtatgaat gtttattatc ttatgtatcg ttttgcttct 360
tggggccaag gcaccctggt gacggttagc tca                              393

<210> 13
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR1; m2CX1D05

<400> 13
Gly Gly Thr Phe Asn Ser His Ala Ile Ser
 1               5                  10  


<210> 14
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> VH CDR1; m2CX1D05

<400> 14
ggaggcactt ttaattctca tgctatttct                                  30

<210> 15
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR2; m2CX1D05

<400> 15
Trp Met Gly Gly Ile Asn Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln
 1               5                  10                  15      
Lys Phe Gln Gly
            20  


<210> 16
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> VH CDR2; m2CX1D05

<400> 16
tggatgggcg gtatcaatcc gattcttggc attgcgaatt acgcgcagaa gtttcagggc 60


<210> 17
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR3; m2CX1D05

<400> 17
His Tyr Glu Ile Gln Ile Gly Arg Tyr Gly Met Asn Val Tyr Tyr Leu
 1               5                  10                  15      
Met Tyr Arg Phe Ala Ser
            20          


<210> 18
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> VH CDR3; m2CX1D05

<400> 18
cattatgaga ttcagattgg tcgttatggt atgaatgttt attatcttat gtatcgtttt 60
gcttct                                                            66

<210> 19
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Internal Processing Site

<400> 19
Ser Ser Val Phe Ala Gln
 1               5      


<210> 20
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Internal Processing Site

<400> 20
Ser Ile Pro Trp Asn Leu
 1               5      


<210> 21
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> contains Fc domain of IgG1

<400> 21
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 22
<211> 326
<212> PRT
<213> Artificial Sequence

<220> 
<223> contains Fc domain of IgG2

<400> 22
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
        115                 120                 125             
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
    130                 135                 140                 
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly
145                 150                 155                 160 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn
                165                 170                 175     
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp
            180                 185                 190         
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro
        195                 200                 205             
Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
    210                 215                 220                 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
225                 230                 235                 240 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
                245                 250                 255     
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
            260                 265                 270         
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
        275                 280                 285             
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
    290                 295                 300                 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
305                 310                 315                 320 
Ser Leu Ser Pro Gly Lys
                325     


<210> 23
<211> 327
<212> PRT
<213> Artificial Sequence

<220> 
<223> contains Fc domain of IgG4

<400> 23
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys
                325         


<210> 24
<211> 326
<212> PRT
<213> Artificial Sequence

<220> 
<223> contains Fc domain of IgG2m4

<400> 24
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
        115                 120                 125             
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
    130                 135                 140                 
Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly
145                 150                 155                 160 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn
                165                 170                 175     
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
            180                 185                 190         
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro
        195                 200                 205             
Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
    210                 215                 220                 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
225                 230                 235                 240 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
                245                 250                 255     
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
            260                 265                 270         
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
        275                 280                 285             
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
    290                 295                 300                 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
305                 310                 315                 320 
Ser Leu Ser Pro Gly Lys
                325     


<210> 25
<211> 457
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1D05 IgG2m4 Heavy Chain

<400> 25
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser His
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Asn Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Tyr Glu Ile Gln Ile Gly Arg Tyr Gly Met Asn Val Tyr
            100                 105                 110         
Tyr Leu Met Tyr Arg Phe Ala Ser Trp Gly Gln Gly Thr Leu Val Thr
        115                 120                 125             
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
    130                 135                 140                 
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val
145                 150                 155                 160 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                165                 170                 175     
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
            180                 185                 190         
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly
        195                 200                 205             
Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys
    210                 215                 220                 
Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys
225                 230                 235                 240 
Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
                245                 250                 255     
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            260                 265                 270         
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
        275                 280                 285             
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    290                 295                 300                 
Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His
305                 310                 315                 320 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                325                 330                 335     
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln
            340                 345                 350         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
        355                 360                 365             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    370                 375                 380                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
385                 390                 395                 400 
Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu
                405                 410                 415     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            420                 425                 430         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        435                 440                 445             
Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455         


<210> 26
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1D05 IgG Light Chain

<400> 26
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Ser Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asn Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Asp Gly Asp Pro Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205             
Asn Arg Gly Glu Cys
    210             


<210> 27
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL; m2CX1D05

<400> 27
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Ser Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asn Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Asp Gly Asp Pro Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105         


<210> 28
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> VL; m2CX1D05

<400> 28
gatatccaga tgacccagag cccgtctagc ctgagcgcga gcgtgggtga tcgtgtgacc 60
attacctgca gagcgagcca gggtattcgt tctgctctga attggtacca gcagaaacca 120
ggtaaagcac cgaaactatt aatttataat ggttctactt tgcaaagcgg ggtcccgtcc 180
cgttttagcg gctctggatc cggcactgat tttaccctga ccattagcag cctgcaacct 240
gaagactttg cggtttatta ttgccagcag tttgatggtg atcctacctt tggccagggt 300
acgaaagttg aaattaaacg t                                           321

<210> 29
<211> 1371
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1D05 IgG2m4 Heavy Chain

<400> 29
caggtgcaat tggttcagtc tggcgcggaa gtgaaaaaac cgggcagcag cgtgaaagtg 60
agctgcaaag cctccggagg cacttttaat tctcatgcta tttcttgggt gcgccaagcc 120
cctgggcagg gtctcgagtg gatgggcggt atcaatccga ttcttggcat tgcgaattac 180
gcgcagaagt ttcagggccg ggtgaccatt accgcggatg aaagcaccag caccgcgtat 240
atggaactga gcagcctgcg tagcgaagat acggccgtgt attattgcgc gcgtcattat 300
gagattcaga ttggtcgtta tggtatgaat gtttattatc ttatgtatcg ttttgcttct 360
tggggccaag gcaccctggt gacggttagc tcagcatcca ccaagggccc atccgtcttc 420
cccctggcgc cctgctccag gagcacctcc gagagcacag ccgccctggg ctgcctggtc 480
aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc 540
gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg 600
accgtgacct ccagcaactt tggcacgcag acctacacct gcaacgtaga tcacaagccc 660
agcaacacca aggtggacaa gacagttgag cggaaatgct gcgtggagtg cccaccatgc 720
ccagcacctc cagtggccgg accatcagtc ttcctgttcc ccccaaaacc caaggacact 780
ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac 840
cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag 900
ccgcgggagg agcagttcaa cagcacgttc cgtgtggtca gcgtcctcac cgtcctgcac 960
caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc 1020
tccatcgaga aaaccatctc caaaaccaaa gggcagcccc gagagccaca ggtgtacacc 1080
ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa 1140
ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac 1200
tacaagacca cgcctcccat gctggactcc gacggctcct tcttcctcta cagcaagcta 1260
accgtggaca agagcaggtg gcagcagggg aatgtcttct catgctccgt gatgcatgag 1320
gctctgcaca accactacac acagaagagc ctctccctgt ctcctggtaa a          1371

<210> 30
<211> 639
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1D05 IgG LIght Chain

<400> 30
gatatccaga tgacccagag cccgtctagc ctgagcgcga gcgtgggtga tcgtgtgacc 60
attacctgca gagcgagcca gggtattcgt tctgctctga attggtacca gcagaaacca 120
ggtaaagcac cgaaactatt aatttataat ggttctactt tgcaaagcgg ggtcccgtcc 180
cgttttagcg gctctggatc cggcactgat tttaccctga ccattagcag cctgcaacct 240
gaagactttg cggtttatta ttgccagcag tttgatggtg atcctacctt tggccagggt 300
acgaaagttg aaattaaacg tacggtggct gcaccatctg tcttcatctt cccgccatct 360
gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc 420
agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag 480
agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg 540
agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg 600
agctcgcccg tcacaaagag cttcaacagg ggagagtgt                        639

<210> 31
<211> 8575
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1D05 IgG2m4 HC Plasmid

<400> 31
cgatagattg tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa 60
tcagcatcca tgttggaatt taatcgcggc ctcgagcaag acgtttcccg ttgaatatgg 120
ctcataacac cccttgtatt actgtttatg taagcagaca gttttattgt tcatgatgat 180
atatttttat cttgtgcaat gtaacatcag agattttgag acacaacgtg gctttccccc 240
cccccccatt attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa 300
tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct 360
gacgtctaag aaaccattat tatcatgaca ttaacctata aaaataggcg tatcacgagg 420
ccctttcgtc tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg 480
gagacggtca cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg 540
tcagcgggtg ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta 600
ctgagagtgc accatatgct taattaacgc ggggcagtgc atgtaatccc ttcagttggt 660
tggtacaact tgccaactgg gccctgttcc acatgtgaca cgggggggga ccaaacacaa 720
aggggttctc tgactgtagt tgacatcctt ataaatggat gtgcacattt gccaacactg 780
agtggctttc atcctggagc agactttgca gtctgtggac tgcaacacaa cattgccttt 840
atgtgtaact cttggctgaa gctcttacac caatgctggg ggacatgtac ctcccagggg 900
cccaggaaga ctacgggagg ctacaccaac gtcaatcaga ggggcctgtg tagctaccga 960
taagcggacc ctcaagaggg cattagcaat agtgtttata aggccccctt gttaacccta 1020
aacgggtagc atatgcttcc cgggtagtag tatatactat ccagactaac cctaattcaa 1080
tagcatatgt tacccaacgg gaagcatatg ctatcgaatt agggttagta aaagggtcct 1140
aaggaacagc gatatctccc accccatgag ctgtcacggt tttatttaca tggggtcagg 1200
attccacgag ggtagtgaac cattttagtc acaagggcag tggctgaaga tcaaggagcg 1260
ggcagtgaac tctcctgaat cttcgcctgc ttcttcattc tccttcgttt agctaataga 1320
ataactgctg agttgtgaac agtaaggtgt atgtgaggtg ctcgaaaaca aggtttcagg 1380
tgacgccccc agaataaaat ttggacgggg ggttcagtgg tggcattgtg ctatgacacc 1440
aatataaccc tcacaaaccc cttgggcaat aaatactagt gtaggaatga aacattctga 1500
atatctttaa caatagaaat ccatggggtg gggacaagcc gtaaagactg gatgtccatc 1560
tcacacgaat ttatggctat gggcaacaca taatcctagt gcaatatgat actggggtta 1620
ttaagatgtg tcccaggcag ggaccaagac aggtgaacca tgttgttaca ctctatttgt 1680
aacaagggga aagagagtgg acgccgacag cagcggactc cactggttgt ctctaacacc 1740
cccgaaaatt aaacggggct ccacgccaat ggggcccata aacaaagaca agtggccact 1800
cttttttttg aaattgtgga gtgggggcac gcgtcagccc ccacacgccg ccctgcggtt 1860
ttggactgta aaataagggt gtaataactt ggctgattgt aaccccgcta accactgcgg 1920
tcaaaccact tgcccacaaa accactaatg gcaccccggg gaatacctgc ataagtaggt 1980
gggcgggcca agataggggc gcgattgctg cgatctggag gacaaattac acacacttgc 2040
gcctgagcgc caagcacagg gttgttggtc ctcatattca cgaggtcgct gagagcacgg 2100
tgggctaatg ttgccatggg tagcatatac tacccaaata tctggatagc atatgctatc 2160
ctaatctata tctgggtagc ataggctatc ctaatctata tctgggtagc atatgctatc 2220
ctaatctata tctgggtagt atatgctatc ctaatttata tctgggtagc ataggctatc 2280
ctaatctata tctgggtagc atatgctatc ctaatctata tctgggtagt atatgctatc 2340
ctaatctgta tccgggtagc atatgctatc ctaatagaga ttagggtagt atatgctatc 2400
ctaatttata tctgggtagc atatactacc caaatatctg gatagcatat gctatcctaa 2460
tctatatctg ggtagcatat gctatcctaa tctatatctg ggtagcatag gctatcctaa 2520
tctatatctg ggtagcatat gctatcctaa tctatatctg ggtagtatat gctatcctaa 2580
tttatatctg ggtagcatag gctatcctaa tctatatctg ggtagcatat gctatcctaa 2640
tctatatctg ggtagtatat gctatcctaa tctgtatccg ggtagcatat gctatcctca 2700
tgcatataca gtcagcatat gatacccagt agtagagtgg gagtgctatc ctttgcatat 2760
gccgccacct cccaaggggg cgtgaatttt cgctgcttgt ccttttcctg cggcgcgccg 2820
tttaaacatt taaatggatc cgcaccatat gcggtgtgaa ataccgcaca gatgcgtaag 2880
gagaaaatac cgcatcagat tggctattgg ccattgcata cgttgtatcc atatcataat 2940
atgtacattt atattggctc atgtccaaca ttaccgccat gttgacattg attattgact 3000
agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc 3060
gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg 3120
acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa 3180
tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca 3240
agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac 3300
atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc 3360
atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga 3420
tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg 3480
gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta 3540
cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc 3600
catccacgct gttttgacct ccatagaaga caccgggacc gatccagcct ccgcggccgg 3660
gaacggtgca ttggaacgcg gattccccgt gccaagagtg acgtaagtac cgcctataga 3720
gtctataggc ccaccccctt ggcttcttat gcatgctata ctgtttttgg cttggggtct 3780
atacaccccc gcttcctcat gttataggtg atggtatagc ttagcctata ggtgtgggtt 3840
attgaccatt attgaccact cccctattgg tgacgatact ttccattact aatccataac 3900
atggctcttt gccacaactc tctttattgg ctatatgcca atacactgtc cttcagagac 3960
tgacacggac tctgtatttt tacaggatgg ggtctcattt attatttaca aattcacata 4020
tacaacacca ccgtccccag tgcccgcagt ttttattaaa cataacgtgg gatctccacg 4080
cgaatctcgg gtacgtgttc cggacatggg ctcttctccg gtagcggcgg agcttctaca 4140
tccgagccct ggtcccatgc ctccagcggc tcatggtcgc tcggcagctc cttgctccta 4200
acagtggagg ccagacttag gcacagcaca atgcccacca ccaccagtgt gccgcacaag 4260
gccgtggcgg tagggtatgt gtctgaaaat gagcgtggag attgggctcg cacggctgac 4320
gcagatggaa gacttaaggc agcggcagaa gaagatgcag gcagctgagt tgttgtattc 4380
tgataagagt cagaggtaac tcccgttgcg gtgctgttaa cggtggaggg cagtgtagtc 4440
tgagcagtac tcgttgctgc cgcgcgcgcc accagacata atagctgaca gactaacaga 4500
ctgttccttt ccatgggtct tttctgcagt caccgtcctt gacacgaagc ttgccgccac 4560
catggaatgg agctgggtct ttctcttctt cctgtcagta actacaggtg tccactcgca 4620
ggtgcaattg gttcagtctg gcgcggaagt gaaaaaaccg ggcagcagcg tgaaagtgag 4680
ctgcaaagcc tccggaggca cttttaattc tcatgctatt tcttgggtgc gccaagcccc 4740
tgggcagggt ctcgagtgga tgggcggtat caatccgatt cttggcattg cgaattacgc 4800
gcagaagttt cagggccggg tgaccattac cgcggatgaa agcaccagca ccgcgtatat 4860
ggaactgagc agcctgcgta gcgaagatac ggccgtgtat tattgcgcgc gtcattatga 4920
gattcagatt ggtcgttatg gtatgaatgt ttattatctt atgtatcgtt ttgcttcttg 4980
gggccaaggc accctggtga cggttagctc agcatccacc aagggcccat ccgtcttccc 5040
cctggcgccc tgctccagga gcacctccga gagcacagcc gccctgggct gcctggtcaa 5100
ggactacttc cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt 5160
gcacaccttc ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac 5220
cgtgacctcc agcaactttg gcacgcagac ctacacctgc aacgtagatc acaagcccag 5280
caacaccaag gtggacaaga cagttgagcg gaaatgctgc gtggagtgcc caccatgccc 5340
agcacctcca gtggccggac catcagtctt cctgttcccc ccaaaaccca aggacactct 5400
catgatctcc cggacccctg aggtcacgtg cgtggtggtg gacgtgagcc aggaagaccc 5460
cgaggtccag ttcaactggt acgtggatgg cgtggaggtg cataatgcca agacaaagcc 5520
gcgggaggag cagttcaaca gcacgttccg tgtggtcagc gtcctcaccg tcctgcacca 5580
ggactggctg aacggcaagg agtacaagtg caaggtctcc aacaaaggcc tcccgtcctc 5640
catcgagaaa accatctcca aaaccaaagg gcagccccga gagccacagg tgtacaccct 5700
gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg 5760
cttctacccc agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta 5820
caagaccacg cctcccatgc tggactccga cggctccttc ttcctctaca gcaagctaac 5880
cgtggacaag agcaggtggc agcaggggaa tgtcttctca tgctccgtga tgcatgaggc 5940
tctgcacaac cactacacac agaagagcct ctccctgtct cctggtaaat gagcggccgc 6000
gatctgctgt gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct 6060
tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc 6120
attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcagcac agcaaggggg 6180
aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg gccgctgaga 6240
tctggccgct gcggccaggt gctgaagaat tgacccggtt cctcctgggc cagaaagaag 6300
caggcacatc cccttctctg tgacacaccc tgtccacgcc cctggttctt agttccagcc 6360
ccactcatag gacactcata gctcaggagg gctccgcctt caatcccacc cgctaaagta 6420
cttggagcgg tctctccctc cctcatcagc ccaccaaacc aaacctagcc tccaagagtg 6480
ggaagaaatt aaagcaagat aggctattaa gtgcagaggg agagaaaatg cctccaacat 6540
gtgaggaagt aatgagagaa atcatagaat ttcttccgct tcctcgctca ctgactcgct 6600
gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt 6660
atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaaggc 6720
caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga 6780
gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata 6840
ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac 6900
cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcaat gctcacgctg 6960
taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc 7020
cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag 7080
acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt 7140
aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaaggacagt 7200
atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg 7260
atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac 7320
gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca 7380
gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac 7440
ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac 7500
ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt 7560
tcgttcatcc atagttgcct gactccgggg ggggggggcg ctgaggtctg cctcgtgaag 7620
aaggtgttgc tgactcatac caggcctgaa tcgccccatc atccagccag aaagtgaggg 7680
agccacggtt gatgagagct ttgttgtagg tggaccagtt ggtgattttg aacttttgct 7740
ttgccacgga acggtctgcg ttgtcgggaa gatgcgtgat ctgatccttc aactcagcaa 7800
aagttcgatt tattcaacaa agccgccgtc ccgtcaagtc agcgtaatgc tctgccagtg 7860
ttacaaccaa ttaaccaatt ctgattagaa aaactcatcg agcatcaaat gaaactgcaa 7920
tttattcata tcaggattat caataccata tttttgaaaa agccgtttct gtaatgaagg 7980
agaaaactca ccgaggcagt tccataggat ggcaagatcc tggtatcggt ctgcgattcc 8040
gactcgtcca acatcaatac aacctattaa tttcccctcg tcaaaaataa ggttatcaag 8100
tgagaaatca ccatgagtga cgactgaatc cggtgagaat ggcaaaagct tatgcatttc 8160
tttccagact tgttcaacag gccagccatt acgctcgtca tcaaaatcac tcgcatcaac 8220
caaaccgtta ttcattcgtg attgcgcctg agcgagacga aatacgcgat cgctgttaaa 8280
aggacaatta caaacaggaa tcgaatgcaa ccggcgcagg aacactgcca gcgcatcaac 8340
aatattttca cctgaatcag gatattcttc taatacctgg aatgctgttt tcccggggat 8400
cgcagtggtg agtaaccatg catcatcagg agtacggata aaatgcttga tggtcggaag 8460
aggcataaat tccgtcagcc agtttagtct gaccatctca tctgtaacat cattggcaac 8520
gctacctttg ccatgtttca gaaacaactc tggcgcatcg ggcttcccat acaat      8575



<210> 32
<211> 9484
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1D05 IgG LC Plasmid

<400> 32
cgatagattg tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa 60
tcagcatcca tgttggaatt taatcgcggc ctcgagcaag acgtttcccg ttgaatatgg 120
ctcataacac cccttgtatt actgtttatg taagcagaca gttttattgt tcatgatgat 180
atatttttat cttgtgcaat gtaacatcag agattttgag acacaacgtg gctttccccc 240
cccccccatt attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa 300
tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct 360
gacgtctaag aaaccattat tatcatgaca ttaacctata aaaataggcg tatcacgagg 420
ccctttcgtc tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg 480
gagacggtca cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg 540
tcagcgggtg ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta 600
ctgagagtgc accatatgct taattaacgc ggggcagtgc atgtaatccc ttcagttggt 660
tggtacaact tgccaactgg gccctgttcc acatgtgaca cgggggggga ccaaacacaa 720
aggggttctc tgactgtagt tgacatcctt ataaatggat gtgcacattt gccaacactg 780
agtggctttc atcctggagc agactttgca gtctgtggac tgcaacacaa cattgccttt 840
atgtgtaact cttggctgaa gctcttacac caatgctggg ggacatgtac ctcccagggg 900
cccaggaaga ctacgggagg ctacaccaac gtcaatcaga ggggcctgtg tagctaccga 960
taagcggacc ctcaagaggg cattagcaat agtgtttata aggccccctt gttaacccta 1020
aacgggtagc atatgcttcc cgggtagtag tatatactat ccagactaac cctaattcaa 1080
tagcatatgt tacccaacgg gaagcatatg ctatcgaatt agggttagta aaagggtcct 1140
aaggaacagc gatatctccc accccatgag ctgtcacggt tttatttaca tggggtcagg 1200
attccacgag ggtagtgaac cattttagtc acaagggcag tggctgaaga tcaaggagcg 1260
ggcagtgaac tctcctgaat cttcgcctgc ttcttcattc tccttcgttt agctaataga 1320
ataactgctg agttgtgaac agtaaggtgt atgtgaggtg ctcgaaaaca aggtttcagg 1380
tgacgccccc agaataaaat ttggacgggg ggttcagtgg tggcattgtg ctatgacacc 1440
aatataaccc tcacaaaccc cttgggcaat aaatactagt gtaggaatga aacattctga 1500
atatctttaa caatagaaat ccatggggtg gggacaagcc gtaaagactg gatgtccatc 1560
tcacacgaat ttatggctat gggcaacaca taatcctagt gcaatatgat actggggtta 1620
ttaagatgtg tcccaggcag ggaccaagac aggtgaacca tgttgttaca ctctatttgt 1680
aacaagggga aagagagtgg acgccgacag cagcggactc cactggttgt ctctaacacc 1740
cccgaaaatt aaacggggct ccacgccaat ggggcccata aacaaagaca agtggccact 1800
cttttttttg aaattgtgga gtgggggcac gcgtcagccc ccacacgccg ccctgcggtt 1860
ttggactgta aaataagggt gtaataactt ggctgattgt aaccccgcta accactgcgg 1920
tcaaaccact tgcccacaaa accactaatg gcaccccggg gaatacctgc ataagtaggt 1980
gggcgggcca agataggggc gcgattgctg cgatctggag gacaaattac acacacttgc 2040
gcctgagcgc caagcacagg gttgttggtc ctcatattca cgaggtcgct gagagcacgg 2100
tgggctaatg ttgccatggg tagcatatac tacccaaata tctggatagc atatgctatc 2160
ctaatctata tctgggtagc ataggctatc ctaatctata tctgggtagc atatgctatc 2220
ctaatctata tctgggtagt atatgctatc ctaatttata tctgggtagc ataggctatc 2280
ctaatctata tctgggtagc atatgctatc ctaatctata tctgggtagt atatgctatc 2340
ctaatctgta tccgggtagc atatgctatc ctaatagaga ttagggtagt atatgctatc 2400
ctaatttata tctgggtagc atatactacc caaatatctg gatagcatat gctatcctaa 2460
tctatatctg ggtagcatat gctatcctaa tctatatctg ggtagcatag gctatcctaa 2520
tctatatctg ggtagcatat gctatcctaa tctatatctg ggtagtatat gctatcctaa 2580
tttatatctg ggtagcatag gctatcctaa tctatatctg ggtagcatat gctatcctaa 2640
tctatatctg ggtagtatat gctatcctaa tctgtatccg ggtagcatat gctatcctca 2700
tgcatataca gtcagcatat gatacccagt agtagagtgg gagtgctatc ctttgcatat 2760
gccgccacct cccaaggggg cgtgaatttt cgctgcttgt ccttttcctg cggcgcgccg 2820
tttaaacatt taaatggatc cgcaccatat gcggtgtgaa ataccgcaca gatgcgtaag 2880
gagaaaatac cgcatcagat tggctattgg ccattgcata cgttgtatcc atatcataat 2940
atgtacattt atattggctc atgtccaaca ttaccgccat gttgacattg attattgact 3000
agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc 3060
gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg 3120
acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa 3180
tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca 3240
agtacgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac 3300
atgaccttat gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc 3360
atggtgatgc ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga 3420
tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg 3480
gactttccaa aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta 3540
cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatcgc ctggagacgc 3600
catccacgct gttttgacct ccatagaaga caccgggacc gatccagcct ccgcggccgg 3660
gaacggtgca ttggaacgcg gattccccgt gccaagagtg acgtaagtac cgcctataga 3720
gtctataggc ccaccccctt ggcttcttat gcatgctata ctgtttttgg cttggggtct 3780
atacaccccc gcttcctcat gttataggtg atggtatagc ttagcctata ggtgtgggtt 3840
attgaccatt attgaccact cccctattgg tgacgatact ttccattact aatccataac 3900
atggctcttt gccacaactc tctttattgg ctatatgcca atacactgtc cttcagagac 3960
tgacacggac tctgtatttt tacaggatgg ggtctcattt attatttaca aattcacata 4020
tacaacacca ccgtccccag tgcccgcagt ttttattaaa cataacgtgg gatctccacg 4080
cgaatctcgg gtacgtgttc cggacatggg ctcttctccg gtagcggcgg agcttctaca 4140
tccgagccct gctcccatgc ctccagcgac tcatggtcgc tcggcagctc cttgctccta 4200
acagtggagg ccagacttag gcacagcacg atgcccacca ccaccagtgt gccgcacaag 4260
gccgtggcgg tagggtatgt gtctgaaaat gagcgtggag attgggctcg cacggctgac 4320
gcagatggaa gacttaaggc agcggcagaa gaagatgcag gcagctgagt tgttgtattc 4380
tgataagagt cagaggtaac tcccgttgcg gtgctgttaa cggtggaggg cagtgtagtc 4440
tgagcagtac tcgttgctgc cgcgcgcgcc accagacata atagctgaca gactaacaga 4500
ctgttccttt ccatgggtct tttctgcagt caccgtcctt gacacgaagc ttgccgccac 4560
catgagtgtg cccactcagg tcctggggtt gctgctgctg tggcttacag atgccagatg 4620
cgatatccag atgacccaga gcccgtctag cctgagcgcg agcgtgggtg atcgtgtgac 4680
cattacctgc agagcgagcc agggtattcg ttctgctctg aattggtacc agcagaaacc 4740
aggtaaagca ccgaaactat taatttataa tggttctact ttgcaaagcg gggtcccgtc 4800
ccgttttagc ggctctggat ccggcactga ttttaccctg accattagca gcctgcaacc 4860
tgaagacttt gcggtttatt attgccagca gtttgatggt gatcctacct ttggccaggg 4920
tacgaaagtt gaaattaaac gtacggtggc tgcaccatct gtcttcatct tcccgccatc 4980
tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc 5040
cagagaggcc aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga 5100
gagtgtcaca gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct 5160
gagcaaagca gactacgaga aacacaaagt ctacgcctgc gaagtcaccc atcagggcct 5220
gagctcgccc gtcacaaaga gcttcaacag gggagagtgt taggcggccg cgatctgctg 5280
tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg 5340
aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga 5400
gtaggtgtca ttctattctg gggggtgggg tggggcagca cagcaagggg gaggattggg 5460
aagacaatag caggcatgct ggggatgcgg tgggctctat ggccgctgag atctggccgc 5520
tgcggccctg tggaatgtgt gtcagttagg gtgtggaaag tccccaggct ccccagcagg 5580
cagaagtatg caaagcatgc atctcaatta gtcagcaacc aggtgtggaa agtccccagg 5640
ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc 5700
gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca 5760
tggctgacta atttttttta tttatgcaga ggccgaggcc gcctctgcct ctgagctatt 5820
ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tgtcgaccac 5880
catggccacc tcagcaagtt cccacttgaa caaaaacatc aagcaaatgt acttgtgcct 5940
gccccagggt gagaaagtcc aagccatgta tatctgggtt gatggtactg gagaaggact 6000
gcgctgcaaa acccgcaccc tggactgtga gcccaagtgt gtagaagagt tacctgagtg 6060
gaattttgat ggctctagta cctttcagtc tgagggctcc aacagtgaca tgtatctcag 6120
ccctgttgcc atgtttcggg accccttccg cagagatccc aacaagctgg tgttctgtga 6180
agttttcaag tacaaccgga agcccgcaga gaccaattta aggcactcgt gtaaacggat 6240
aatggacatg gtgagcaacc agcacccctg gtttggaatg gaacaggagt atactctgat 6300
gggaacagat gggcaccctt ttggttggcc ttccaatggc tttcctggac cccaaggtcc 6360
gtattactgt ggtgtgggcg cagacaaagc ctatggcagg gacatcgtgg aggctcacta 6420
ccgcgcctgc ttgtatgctg gggtcaagat tacaggaaca aatgctgagg tcatgcctgc 6480
ccagtgggag ttccaaatag gaccctgtga aggaatccgc atgggagatc atctctgggt 6540
ggcccgtttc atcttgcatc gagtatgtga agactttggg gtaatagcaa cctttgaccc 6600
caagcccatt cctgggaact ggaatggtgc aggctgccat accaacttta gcaccaaggc 6660
catgcgggag gagaatggtc tgaagcacat cgaggaggcc atcgagaaac taagcaagcg 6720
gcaccggtat cacattcgag cctacgatcc caaggggggc ctggacaatg cccgtggtct 6780
gactgggttc cacgaaacgt ccaacatcaa cgacttttct gctggtgtcg ccaatcgcag 6840
tgccagcatc cgcattcccc ggactgtcgg ccaggagaag aaaggttact ttgaagaccg 6900
ccgcccctct gccaattgtg acccctttgc agtgacagaa gccatcgtcc gcacatgcct 6960
tctcaatgag actggcgacg agcccttcca atacaaaaac taagtcgaca acttgtttat 7020
tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 7080
tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg 7140
gatcggcgcg ccggccgctg cggccaggtg ctgaagaatt gacccggttc ctcctgggcc 7200
agaaagaagc aggcacatcc ccttctctgt gacacaccct gtccacgccc ctggttctta 7260
gttccagccc cactcatagg acactcatag ctcaggaggg ctccgccttc aatcccaccc 7320
gctaaagtac ttggagcggt ctctccctcc ctcatcagcc caccaaacca aacctagcct 7380
ccaagagtgg gaagaaatta aagcaagata ggctattaag tgcagaggga gagaaaatgc 7440
ctccaacatg tgaggaagta atgagagaaa tcatagaatt tcttccgctt cctcgctcac 7500
tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt 7560
aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca 7620
gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc 7680
ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact 7740
ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct 7800
gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcaatg 7860
ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca 7920
cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa 7980
cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc 8040
gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag 8100
aaggacagta tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg 8160
tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca 8220
gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc 8280
tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag 8340
gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata 8400
tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat 8460
ctgtctattt cgttcatcca tagttgcctg actccggggg gggggggcgc tgaggtctgc 8520
ctcgtgaaga aggtgttgct gactcatacc aggcctgaat cgccccatca tccagccaga 8580
aagtgaggga gccacggttg atgagagctt tgttgtaggt ggaccagttg gtgattttga 8640
acttttgctt tgccacggaa cggtctgcgt tgtcgggaag atgcgtgatc tgatccttca 8700
actcagcaaa agttcgattt attcaacaaa gccgccgtcc cgtcaagtca gcgtaatgct 8760
ctgccagtgt tacaaccaat taaccaattc tgattagaaa aactcatcga gcatcaaatg 8820
aaactgcaat ttattcatat caggattatc aataccatat ttttgaaaaa gccgtttctg 8880
taatgaagga gaaaactcac cgaggcagtt ccataggatg gcaagatcct ggtatcggtc 8940
tgcgattccg actcgtccaa catcaataca acctattaat ttcccctcgt caaaaataag 9000
gttatcaagt gagaaatcac catgagtgac gactgaatcc ggtgagaatg gcaaaagctt 9060
atgcatttct ttccagactt gttcaacagg ccagccatta cgctcgtcat caaaatcact 9120
cgcatcaacc aaaccgttat tcattcgtga ttgcgcctga gcgagacgaa atacgcgatc 9180
gctgttaaaa ggacaattac aaacaggaat cgaatgcaac cggcgcagga acactgccag 9240
cgcatcaaca atattttcac ctgaatcagg atattcttct aatacctgga atgctgtttt 9300
cccggggatc gcagtggtga gtaaccatgc atcatcagga gtacggataa aatgcttgat 9360
ggtcggaaga ggcataaatt ccgtcagcca gtttagtctg accatctcat ctgtaacatc 9420
attggcaacg ctacctttgc catgtttcag aaacaactct ggcgcatcgg gcttcccata 9480
caat                                                              9484



<210> 33
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 33
acagatgcca gatgcgatat ccagatgacc caga                             34

<210> 34
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 34
tgcagccacc gtacgtttaa tttcaacttt cgtacc                           36

<210> 35
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 35
acaggtgtcc actcgcaggt gcaattggtt cagtct                           36

<210> 36
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 36
gcccttggtg gatgctgagc taaccgtcac cagggt                           36

<210> 37
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Epitope Domain

<400> 37
Arg Glu Ile Glu Gly Arg
 1               5      


<210> 38
<211> 585
<212> PRT
<213> Homo Sapiens

<400> 38
Ser Ile Pro Trp Asn Leu Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala
 1               5                  10                  15      
Asp Glu Tyr Gln Pro Pro Asp Gly Gly Ser Leu Val Glu Val Tyr Leu
            20                  25                  30          
Leu Asp Thr Ser Ile Gln Ser Asp His Arg Glu Ile Glu Gly Arg Val
        35                  40                  45              
Met Val Thr Asp Phe Glu Asn Val Pro Glu Glu Asp Gly Thr Arg Phe
    50                  55                  60                  
His Arg Gln Ala Ser Lys Cys Asp Ser His Gly Thr His Leu Ala Gly
65                  70                  75                  80  
Val Val Ser Gly Arg Asp Ala Gly Val Ala Lys Gly Ala Ser Met Arg
                85                  90                  95      
Ser Leu Arg Val Leu Asn Cys Gln Gly Lys Gly Thr Val Ser Gly Thr
            100                 105                 110         
Leu Ile Gly Leu Glu Phe Ile Arg Lys Ser Gln Leu Val Gln Pro Val
        115                 120                 125             
Gly Pro Leu Val Val Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val
    130                 135                 140                 
Leu Asn Ala Ala Cys Gln Arg Leu Ala Arg Ala Gly Val Val Leu Val
145                 150                 155                 160 
Thr Ala Ala Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala
                165                 170                 175     
Ser Ala Pro Glu Val Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln
            180                 185                 190         
Pro Val Thr Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp
        195                 200                 205             
Leu Phe Ala Pro Gly Glu Asp Ile Ile Gly Ala Ser Ser Asp Cys Ser
    210                 215                 220                 
Thr Cys Phe Val Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala His Val
225                 230                 235                 240 
Ala Gly Ile Ala Ala Met Met Leu Ser Ala Glu Pro Glu Leu Thr Leu
                245                 250                 255     
Ala Glu Leu Arg Gln Arg Leu Ile His Phe Ser Ala Lys Asp Val Ile
            260                 265                 270         
Asn Glu Ala Trp Phe Pro Glu Asp Gln Arg Val Leu Thr Pro Asn Leu
        275                 280                 285             
Val Ala Ala Leu Pro Pro Ser Thr His Gly Ala Gly Trp Gln Leu Phe
    290                 295                 300                 
Cys Arg Thr Val Trp Ser Ala His Ser Gly Pro Thr Arg Met Ala Thr
305                 310                 315                 320 
Ala Ile Ala Arg Cys Ala Pro Asp Glu Glu Leu Leu Ser Cys Ser Ser
                325                 330                 335     
Phe Ser Arg Ser Gly Lys Arg Arg Gly Glu Arg Met Glu Ala Gln Gly
            340                 345                 350         
Gly Lys Leu Val Cys Arg Ala His Asn Ala Phe Gly Gly Glu Gly Val
        355                 360                 365             
Tyr Ala Ile Ala Arg Cys Cys Leu Leu Pro Gln Ala Asn Cys Ser Val
    370                 375                 380                 
His Thr Ala Pro Pro Ala Glu Ala Ser Met Gly Thr Arg Val His Cys
385                 390                 395                 400 
His Gln Gln Gly His Val Leu Thr Gly Cys Ser Ser His Trp Glu Val
                405                 410                 415     
Glu Asp Leu Gly Thr His Lys Pro Pro Val Leu Arg Pro Arg Gly Gln
            420                 425                 430         
Pro Asn Gln Cys Val Gly His Arg Glu Ala Ser Ile His Ala Ser Cys
        435                 440                 445             
Cys His Ala Pro Gly Leu Glu Cys Lys Val Lys Glu His Gly Ile Pro
    450                 455                 460                 
Ala Pro Gln Glu Gln Val Thr Val Ala Cys Glu Glu Gly Trp Thr Leu
465                 470                 475                 480 
Thr Gly Cys Ser Ala Leu Pro Gly Thr Ser His Val Leu Gly Ala Tyr
                485                 490                 495     
Ala Val Asp Asn Thr Cys Val Val Arg Ser Arg Asp Val Ser Thr Thr
            500                 505                 510         
Gly Ser Thr Ser Glu Glu Ala Val Thr Ala Val Ala Ile Cys Cys Arg
        515                 520                 525             
Ser Arg His Leu Ala Gln Ala Ser Gln Glu Leu Gln Lys Gly Asn Ser
    530                 535                 540                 
Ala Asp Ile Gln His Ser Gly Gly Arg Ser Ser Leu Glu Gly Pro Arg
545                 550                 555                 560 
Phe Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr
                565                 570                 575     
Arg Thr Gly His His His His His His
            580                 585 


<210> 39
<211> 53
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human Epitope Area

<400> 39
Ser Ile Pro Trp Asn Leu Glu Arg Ile Thr Pro Pro Arg Tyr Arg Ala
 1               5                  10                  15      
Asp Glu Tyr Gln Pro Pro Asp Gly Gly Ser Leu Val Glu Val Tyr Leu
            20                  25                  30          
Leu Asp Thr Ser Ile Gln Ser Asp His Arg Glu Ile Glu Gly Arg Val
        35                  40                  45              
Met Val Thr Asp Phe
    50              


<210> 40
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> Consensus Epitope Area

<400> 40
Ser Ile Pro Trp Asn Leu Glu Arg Ile Pro Glu Pro Asp Gly Ser Val
 1               5                  10                  15      
Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln His Arg Glu Ile Glu Gly
            20                  25                  30          
Arg Val Thr Asp Phe
        35          


<210> 41
<211> 53
<212> PRT
<213> Mouse

<400> 41
Ser Ile Pro Trp Asn Leu Glu Arg Ile Ile Pro Ala Trp His Gln Thr
 1               5                  10                  15      
Glu Glu Asp Arg Ser Pro Asp Gly Ser Ser Gln Val Glu Val Tyr Leu
            20                  25                  30          
Leu Asp Thr Ser Ile Gln Gly Ala His Arg Glu Ile Glu Gly Arg Val
        35                  40                  45              
Thr Ile Thr Asp Phe
    50              


<210> 42
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Secondary Footprint Epitope

<400> 42
Arg Tyr Arg Ala Asp
 1               5  


<210> 43
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1D05 Antibody Variant VH CDR1 Sequence

<221> VARIANT        
<222> 6
<223> Xaa = Ser or Asn

<221> VARIANT        
<222> 7
<223> Xaa = His, Asp, Tyr, Phe or Glu

<400> 43
Gly Gly Thr Phe Asn Xaa Xaa Ala Ile Ser
 1               5                  10  


<210> 44
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1D05 Antibody Variant VH CDR2 Sequence

<221> VARIANT        
<222> 6
<223> Xaa = Asn or Ile

<221> VARIANT        
<222> 8
<223> Xaa = Ile, Asn, Ser, Gly or Tyr

<221> VARIANT        
<222> 9
<223> Xaa = Leu or Asn

<221> VARIANT        
<222> 11
<223> Xaa = Ile, Asp, Thr, Asn, Ser or Gly

<221> VARIANT        
<222> 12
<223> Xaa = Ala or Thr

<400> 44
Trp Met Gly Gly Ile Xaa Pro Xaa Xaa Gly Xaa Xaa Asn Tyr Ala Gln
 1               5                  10                  15      
Lys Phe Gln Gly
            20  


<210> 45
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1D05 Antibody Variant VH CDR3 Sequence

<221> VARIANT        
<222> 1
<223> Xaa = His, Tyr, Phe or Glu

<221> VARIANT        
<222> 4
<223> Xaa = Ile or Ser

<221> VARIANT        
<222> 5
<223> Xaa = Gln, Gly or Arg

<221> VARIANT        
<222> 6
<223> Xaa = Ile or Val

<221> VARIANT        
<222> 11
<223> Xaa = Met or Leu

<221> VARIANT        
<222> (12)...(12)
<223> Xaa = Asn or Thr

<221> VARIANT        
<222> (13)...(13)
<223> Xaa = Val or Arg

<221> VARIANT        
<222> (16)...(16)
<223> Xaa = Leu, Phe or Tyr

<221> VARIANT        
<222> (17)...(17)
<223> Xaa = Met, Tyr, Leu or Phe

<221> VARIANT        
<222> (19)...(19)
<223> Xaa = Arg, Gly or Tyr

<221> VARIANT        
<222> (20)...(20)
<223> Xaa = Phe or Leu

<221> VARIANT        
<222> (21)...(21)
<223> Xaa = Ala or Asp

<221> VARIANT        
<222> (22)...(22)
<223> Xaa = Ser, Ala, Leu or Val

<400> 45
Xaa Tyr Glu Xaa Xaa Xaa Gly Arg Tyr Gly Xaa Xaa Xaa Tyr Tyr Xaa
 1               5                  10                  15      
Xaa Tyr Xaa Xaa Xaa Xaa
            20          


<210> 46
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1D05 Antibody Variant VL CDR1 Sequence

<221> VARIANT        
<222> 5
<223> Xaa = Gly, Ser, Asp or Asn

<221> VARIANT        
<222> 7
<223> Xaa = Arg or Gln

<221> VARIANT        
<222> 8
<223> Xaa = Ser, Asn, Thr, Arg or Lys

<221> VARIANT        
<222> 9
<223> Xaa = Ala, Tyr or Asn

<400> 46
Arg Ala Ser Gln Xaa Ile Xaa Xaa Xaa Leu Asn
 1               5                  10      


<210> 47
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1D05 Antibody Variant VL CDR2 Sequence

<221> VARIANT        
<222> 5
<223> Xaa = Asn, Asp, Tyr, Thr, Ala,  Gly or Gln

<221> VARIANT        
<222> 6
<223> Xaa = Gly or Ala

<221> VARIANT        
<222> 8
<223> Xaa = Thr or Arg

<400> 47
Leu Leu Ile Tyr Xaa Xaa Ser Xaa Leu Gln Ser
 1               5                  10      


<210> 48
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> 1D05 Antibody Variant VL CDR3 Sequence

<221> VARIANT        
<222> 3
<223> Xaa = Phe or Tyr

<221> VARIANT        
<222> 4
<223> Xaa = Asp or Asn, Gly, Tyr or Ser

<221> VARIANT        
<222> 5
<223> Xaa = Gly, Ser, Asn or Arg

<400> 48
Gln Gln Xaa Xaa Xaa Asp Pro
 1               5          


<210> 49
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL; 1D05 VARIANT SEQUENCE

<221> VARIANT        
<222> 28
<223> Xaa = Gly, Ser, Asp or Asn

<221> VARIANT        
<222> 30
<223> Xaa = Arg or Gln

<221> VARIANT        
<222> 31
<223> Xaa = Ser, Asn, Thr, Arg or Lys

<221> VARIANT        
<222> 32
<223> Xaa = Ala, Tyr or Asn

<221> VARIANT        
<222> 50
<223> Asn, Asp, Tyr, Thr, Ala, Gly or Gln

<221> VARIANT        
<222> (51)...(51)
<223> Xaa = Gly or Ala

<221> VARIANT        
<222> (53)...(53)
<223> Xaa = Thr or Arg

<221> VARIANT        
<222> (91)...(91)
<223> Xaa = Phe or Tyr

<221> VARIANT        
<222> (92)...(92)
<223> Xaa = Asp, Asn, Gly, Tyr or Ser

<221> VARIANT        
<222> (93)...(93)
<223> Xaa = Gly, Ser, Asn or Arg

<400> 49
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Xaa Ile Xaa Xaa Xaa
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Xaa Xaa Ser Xaa Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Xaa Xaa Xaa Asp Pro Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105         


<210> 50
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1D05 VARIANT SEQUENCE

<221> VARIANT        
<222> 31
<223> Xaa = Ser or Asn

<221> VARIANT        
<222> 32
<223> Xaa = His, Asp, Tyr, Phe or Glu

<221> VARIANT        
<222> 52
<223> Xaa = Asn or Ile

<221> VARIANT        
<222> 54
<223> Xaa = Ile, Asn, Ser, Gly or Tyr

<221> VARIANT        
<222> 55
<223> Xaa = Leu or Asn

<221> VARIANT        
<222> (57)...(57)
<223> Xaa = Ile, Asp, Thr, Asn, Ser or Gly

<221> VARIANT        
<222> (58)...(58)
<223> Xaa = Ala or Thr

<221> VARIANT        
<222> (99)...(99)
<223> Xaa = His, Tyr, Phe or Glu

<221> VARIANT        
<222> (102)...(102)
<223> Xaa = Ile or Ser

<221> VARIANT        
<222> (103)...(103)
<223> Xaa = Gln, Gly or Arg

<221> VARIANT        
<222> (104)...(104)
<223> Xaa = Ile or Val

<221> VARIANT        
<222> (109)...(109)
<223> Xaa = Met or Leu

<221> VARIANT        
<222> (110)...(110)
<223> Xaa = Asn or Thr

<221> VARIANT        
<222> (111)...(111)
<223> Xaa = Val or Arg

<221> VARIANT        
<222> (114)...(114)
<223> Xaa = Leu, Phe or Tyr

<221> VARIANT        
<222> (115)...(115)
<223> Xaa= Met, Tyr, Leu or Phe

<221> VARIANT        
<222> (117)...(120)
<223> Xaa = Arg, Gly or Tyr at position 117; Phe or Leu
      at position 118; Ala or Asp at position 119; Ser,
      Ala, Leu or Val at position 120

<400> 50
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Xaa Xaa
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Xaa Pro Xaa Xaa Gly Xaa Xaa Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Xaa Tyr Glu Xaa Xaa Xaa Gly Arg Tyr Gly Xaa Xaa Xaa Tyr
            100                 105                 110         
Tyr Xaa Xaa Tyr Xaa Xaa Xaa Xaa Trp Gly Gln Gly Thr Leu Val Thr
        115                 120                 125             
Val Ser Ser
    130     


<210> 51
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1D05 VARIANT SEQUENCE H32Y

<400> 51
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser Tyr
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Asn Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Tyr Glu Ile Gln Ile Gly Arg Tyr Gly Met Asn Val Tyr
            100                 105                 110         
Tyr Leu Met Tyr Arg Phe Ala Ser Trp Gly Gln Gly Thr Leu Val Thr
        115                 120                 125             
Val Ser Ser
    130     


<210> 52
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1D05 VARIANT SEQUENCE M48A

<400> 52
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser His
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ala
        35                  40                  45              
Gly Gly Ile Asn Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Tyr Glu Ile Gln Ile Gly Arg Tyr Gly Met Asn Val Tyr
            100                 105                 110         
Tyr Leu Met Tyr Arg Phe Ala Ser Trp Gly Gln Gly Thr Leu Val Thr
        115                 120                 125             
Val Ser Ser
    130     


<210> 53
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1D05 VARIANT SEQUENCE M48L

<400> 53
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser His
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Gly Ile Asn Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Tyr Glu Ile Gln Ile Gly Arg Tyr Gly Met Asn Val Tyr
            100                 105                 110         
Tyr Leu Met Tyr Arg Phe Ala Ser Trp Gly Gln Gly Thr Leu Val Thr
        115                 120                 125             
Val Ser Ser
    130     


<210> 54
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1D05 VARIANT SEQUENCE H99Y

<400> 54
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser His
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Asn Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Tyr Glu Ile Gln Ile Gly Arg Tyr Gly Met Asn Val Tyr
            100                 105                 110         
Tyr Leu Met Tyr Arg Phe Ala Ser Trp Gly Gln Gly Thr Leu Val Thr
        115                 120                 125             
Val Ser Ser
    130     


<210> 55
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1D05 VARIANT SEQUENCE M48LM109LM115L

<400> 55
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser His
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Gly Ile Asn Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Tyr Glu Ile Gln Ile Gly Arg Tyr Gly Leu Asn Val Tyr
            100                 105                 110         
Tyr Leu Leu Tyr Arg Phe Ala Ser Trp Gly Gln Gly Thr Leu Val Thr
        115                 120                 125             
Val Ser Ser
    130     


<210> 56
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1D05 VARIANT SEQUENCE M48V

<400> 56
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser His
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val
        35                  40                  45              
Gly Gly Ile Asn Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg His Tyr Glu Ile Gln Ile Gly Arg Tyr Gly Met Asn Val Tyr
            100                 105                 110         
Tyr Leu Met Tyr Arg Phe Ala Ser Trp Gly Gln Gly Thr Leu Val Thr
        115                 120                 125             
Val Ser Ser
    130     


<210> 57
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL; 1D05 VARIANT SEQUENCE N50D

<400> 57
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Ser Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asp Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Asp Gly Asp Pro Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105         


<210> 58
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1D05 VARIANT SEQUENCE N50Q

<400> 58
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Ser Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gln Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Asp Gly Asp Pro Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105         


<210> 59
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1D05 VARIANT SEQUENCE N50T

<400> 59
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Ser Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Thr Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Asp Gly Asp Pro Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105         


<210> 60
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH; 1D05 VARIANT SEQUENCE N50Y

<400> 60
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Ser Ala
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Asp Gly Asp Pro Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105         

