                         SEQUENCE LISTING

<110>  Wyeth
       Catholic Healthcare West
       Shi, Fu-Dong
       Young, Deborah
       Collins, Mary
       Vollmer, Timothy
       Liu, Ruolan
       Piao, Wenhua
 
<120>  INTERLEUKIN-21 (IL-21) AND IL-21 RECEPTOR (IL-21R) MODULATION OF 
       REGULATORY T CELLS AND FORKHEAD BOX P3 (FOXP3)

<130>  01997.069600.PC

<150>  US 61/025,586
<151>  2008-02-01

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  3248
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (121)..(1737)

<400>  1
ctagaggcag ctcagataga ggagctcttt gggaagagac gccgggcagg cagaagcagc       60

aggtaccccc tccacatccc tagggctctg tgatgtaggc agaggcccgt gggagtcagc      120

atg ccg cgt ggc tgg gcc gcc ccc ttg ctc ctg ctg ctg ctc cag gga        168
Met Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln Gly           
1               5                   10                  15                

ggc tgg ggc tgc ccc gac ctc gtc tgc tac acc gat tac ctc cag acg        216
Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln Thr           
            20                  25                  30                    

gtc atc tgc atc ctg gaa atg tgg aac ctc cac ccc agc acg ctc acc        264
Val Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr Leu Thr           
        35                  40                  45                        

ctt acc tgg caa gac cag tat gaa gag ctg aag gac gag gcc acc tcc        312
Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu Ala Thr Ser           
    50                  55                  60                            

tgc agc ctc cac agg tcg gcc cac aat gcc acg cat gcc acc tac acc        360
Cys Ser Leu His Arg Ser Ala His Asn Ala Thr His Ala Thr Tyr Thr           
65                  70                  75                  80            

tgc cac atg gat gta ttc cac ttc atg gcc gac gac att ttc agt gtc        408
Cys His Met Asp Val Phe His Phe Met Ala Asp Asp Ile Phe Ser Val           
                85                  90                  95                

aac atc aca gac cag tct ggc aac tac tcc cag gag tgt ggc agc ttt        456
Asn Ile Thr Asp Gln Ser Gly Asn Tyr Ser Gln Glu Cys Gly Ser Phe           
            100                 105                 110                   

ctc ctg gct gag agc atc aag ccg gct ccc cct ttc aac gtg act gtg        504
Leu Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Phe Asn Val Thr Val           
        115                 120                 125                       

acc ttc tca gga cag tat aat atc tcc tgg cgc tca gat tac gaa gac        552
Thr Phe Ser Gly Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp           
    130                 135                 140                           

cct gcc ttc tac atg ctg aag ggc aag ctt cag tat gag ctg cag tac        600
Pro Ala Phe Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr           
145                 150                 155                 160           

agg aac cgg gga gac ccc tgg gct gtg agt ccg agg aga aag ctg atc        648
Arg Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile           
                165                 170                 175               

tca gtg gac tca aga agt gtc tcc ctc ctc ccc ctg gag ttc cgc aaa        696
Ser Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe Arg Lys           
            180                 185                 190                   

gac tcg agc tat gag ctg cag gtg cgg gca ggg ccc atg cct ggc tcc        744
Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly Pro Met Pro Gly Ser           
        195                 200                 205                       

tcc tac cag ggg acc tgg agt gaa tgg agt gac ccg gtc atc ttt cag        792
Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln           
    210                 215                 220                           

acc cag tca gag gag tta aag gaa ggc tgg aac cct cac ctg ctg ctt        840
Thr Gln Ser Glu Glu Leu Lys Glu Gly Trp Asn Pro His Leu Leu Leu           
225                 230                 235                 240           

ctc ctc ctg ctt gtc ata gtc ttc att cct gcc ttc tgg agc ctg aag        888
Leu Leu Leu Leu Val Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys           
                245                 250                 255               

acc cat cca ttg tgg agg cta tgg aag aag ata tgg gcc gtc ccc agc        936
Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser           
            260                 265                 270                   

cct gag cgg ttc ttc atg ccc ctg tac aag ggc tgc agc gga gac ttc        984
Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe           
        275                 280                 285                       

aag aaa tgg gtg ggt gca ccc ttc act ggc tcc agc ctg gag ctg gga       1032
Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly           
    290                 295                 300                           

ccc tgg agc cca gag gtg ccc tcc acc ctg gag gtg tac agc tgc cac       1080
Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His           
305                 310                 315                 320           

cca cca cgg agc ccg gcc aag agg ctg cag ctc acg gag cta caa gaa       1128
Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu           
                325                 330                 335               

cca gca gag ctg gtg gag tct gac ggt gtg ccc aag ccc agc ttc tgg       1176
Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp           
            340                 345                 350                   

ccg aca gcc cag aac tcg ggg ggc tca gct tac agt gag gag agg gat       1224
Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp           
        355                 360                 365                       

cgg cca tac ggc ctg gtg tcc att gac aca gtg act gtg cta gat gca       1272
Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala           
    370                 375                 380                           

gag ggg cca tgc acc tgg ccc tgc agc tgt gag gat gac ggc tac cca       1320
Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro           
385                 390                 395                 400           

gcc ctg gac ctg gat gct ggc ctg gag ccc agc cca ggc cta gag gac       1368
Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp           
                405                 410                 415               

cca ctc ttg gat gca ggg acc aca gtc ctg tcc tgt ggc tgt gtc tca       1416
Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser           
            420                 425                 430                   

gct ggc agc cct ggg cta gga ggg ccc ctg gga agc ctc ctg gac aga       1464
Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg           
        435                 440                 445                       

cta aag cca ccc ctt gca gat ggg gag gac tgg gct ggg gga ctg ccc       1512
Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro           
    450                 455                 460                           

tgg ggt ggc cgg tca cct gga ggg gtc tca gag agt gag gcg ggc tca       1560
Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser           
465                 470                 475                 480           

ccc ctg gcc ggc ctg gat atg gac acg ttt gac agt ggc ttt gtg ggc       1608
Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly           
                485                 490                 495               

tct gac tgc agc agc cct gtg gag tgt gac ttc acc agc ccc ggg gac       1656
Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp           
            500                 505                 510                   

gaa gga ccc ccc cgg agc tac ctc cgc cag tgg gtg gtc att cct ccg       1704
Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro           
        515                 520                 525                       

cca ctt tcg agc cct gga ccc cag gcc agc taa tgaggctgac tggatgtcca     1757
Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser                                   
    530                 535                                               

gagctggcca ggccactggg ccctgagcca gagacaaggt cacctgggct gtgatgtgaa     1817

gacacctgca gcctttggtc tcctggatgg gcctttgagc ctgatgttta cagtgtctgt     1877

gtgtgtgtgt gcatatgtgt gtgtgtgcat atgcatgtgt gtgtgtgtgt gtgtcttagg     1937

tgcgcagtgg catgtccacg tgtgtgtgtg attgcacgtg cctgtgggcc tgggataatg     1997

cccatggtac tccatgcatt cacctgccct gtgcatgtct ggactcacgg agctcaccca     2057

tgtgcacaag tgtgcacagt aaacgtgttt gtggtcaaca gatgacaaca gccgtcctcc     2117

ctcctagggt cttgtgttgc aagttggtcc acagcatctc cggggctttg tgggatcagg     2177

gcattgcctg tgactgaggc ggagcccagc cctccagcgt ctgcctccag gagctgcaag     2237

aagtccatat tgttccttat cacctgccaa caggaagcga aaggggatgg agtgagccca     2297

tggtgacctc gggaatggca attttttggg cggcccctgg acgaaggtct gaatcccgac     2357

tctgatacct tctggctgtg ctacctgagc caagtcgcct cccctctctg ggctagagtt     2417

tccttatcca gacagtgggg aaggcatgac acacctgggg gaaattggcg atgtcacccg     2477

tgtacggtac gcagcccaga gcagaccctc aataaacgtc agcttccttc cttctgcggc     2537

cagagccgag gcgggcgggg gtgagaacat caatcgtcag cgacagcctg ggcacccgcg     2597

gggccgtccc gcctgcagag ggccactcgg gggggtttcc aggcttaaaa tcagtccgtt     2657

tcgtctcttg gaaacagctc cccaccaacc aagatttctt tttctaactt ctgctactaa     2717

gtttttaaaa attcccttta tgcacccaag agatatttat taaacaccaa ttacgtagca     2777

ggccatggct catgggaccc accccccgtg gcactcatgg agggggctgc aggttggaac     2837

tatgcagtgt gctccggcca cacatcctgc tgggccccct accctgcccc aattcaatcc     2897

tgccaataaa tcctgtctta tttgttcatc ctggagaatt gaagggaggt caagttgttt     2957

gtcaatgatt tgtcagagaa cctgttgaaa tgtgaattaa gaagctaaga aaatatttct     3017

tagcaacatt ttctttttct tttttttttt tttcttttga gacagagtct cactctcgtc     3077

gcccaggctg gaatgcagtg gtgcgatctc ggctctctgc aacctctgtc tcccgggttc     3137

aagcgatttc ctgcgtcagc cccagagtag ctggaattac aggcacacac caccacgcct     3197

ggctaatttt tgtattttta gtagagctgg ggccaccctg gcccggcccc g              3248


<210>  2
<211>  538
<212>  PRT
<213>  homo sapiens

<400>  2

Met Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln Gly 
1               5                   10                  15      


Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln Thr 
            20                  25                  30          


Val Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr Leu Thr 
        35                  40                  45              


Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu Ala Thr Ser 
    50                  55                  60                  


Cys Ser Leu His Arg Ser Ala His Asn Ala Thr His Ala Thr Tyr Thr 
65                  70                  75                  80  


Cys His Met Asp Val Phe His Phe Met Ala Asp Asp Ile Phe Ser Val 
                85                  90                  95      


Asn Ile Thr Asp Gln Ser Gly Asn Tyr Ser Gln Glu Cys Gly Ser Phe 
            100                 105                 110         


Leu Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Phe Asn Val Thr Val 
        115                 120                 125             


Thr Phe Ser Gly Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp 
    130                 135                 140                 


Pro Ala Phe Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr 
145                 150                 155                 160 


Arg Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile 
                165                 170                 175     


Ser Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe Arg Lys 
            180                 185                 190         


Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly Pro Met Pro Gly Ser 
        195                 200                 205             


Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 
    210                 215                 220                 


Thr Gln Ser Glu Glu Leu Lys Glu Gly Trp Asn Pro His Leu Leu Leu 
225                 230                 235                 240 


Leu Leu Leu Leu Val Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys 
                245                 250                 255     


Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser 
            260                 265                 270         


Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe 
        275                 280                 285             


Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly 
    290                 295                 300                 


Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His 
305                 310                 315                 320 


Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu 
                325                 330                 335     


Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp 
            340                 345                 350         


Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp 
        355                 360                 365             


Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala 
    370                 375                 380                 


Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro 
385                 390                 395                 400 


Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp 
                405                 410                 415     


Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser 
            420                 425                 430         


Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg 
        435                 440                 445             


Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro 
    450                 455                 460                 


Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser 
465                 470                 475                 480 


Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly 
                485                 490                 495     


Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp 
            500                 505                 510         


Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro 
        515                 520                 525             


Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
    530                 535             


<210>  3
<211>  2598
<212>  DNA
<213>  mus musculus


<220>
<221>  CDS
<222>  (391)..(1980)

<400>  3
cagctgtctg cccacttctc ctgtggtgtg cctcacggtc acttgcttgt ctgaccgcaa       60

gtctgcccat ccctggggca gccaactggc ctcagcccgt gccccaggcg tgccctgtct      120

ctgtctggct gccccagccc tactgtcttc ctctgtgtag gctctgccca gatgcccggc      180

tggtcctcag cctcaggact atctcagcag tgactcccct gattctggac ttgcacctga      240

ctgaactcct gcccacctca aaccttcacc tcccaccacc accactccga gtcccgctgt      300

gactcccacg cccaggagac cacccaagtg ccccagccta aagaatggct ttctgagaaa      360

gaccctgaag gagtaggtct gggacacagc atg ccc cgg ggc cca gtg gct gcc       414
                                 Met Pro Arg Gly Pro Val Ala Ala          
                                 1               5                        

tta ctc ctg ctg att ctc cat gga gct tgg agc tgc ctg gac ctc act        462
Leu Leu Leu Leu Ile Leu His Gly Ala Trp Ser Cys Leu Asp Leu Thr           
    10                  15                  20                            

tgc tac act gac tac ctc tgg acc atc acc tgt gtc ctg gag aca cgg        510
Cys Tyr Thr Asp Tyr Leu Trp Thr Ile Thr Cys Val Leu Glu Thr Arg           
25                  30                  35                  40            

agc ccc aac ccc agc ata ctc agt ctc acc tgg caa gat gaa tat gag        558
Ser Pro Asn Pro Ser Ile Leu Ser Leu Thr Trp Gln Asp Glu Tyr Glu           
                45                  50                  55                

gaa ctt cag gac caa gag acc ttc tgc agc cta cac agg tct ggc cac        606
Glu Leu Gln Asp Gln Glu Thr Phe Cys Ser Leu His Arg Ser Gly His           
            60                  65                  70                    

aac acc aca cat ata tgg tac acg tgc cat atg cgc ttg tct caa ttc        654
Asn Thr Thr His Ile Trp Tyr Thr Cys His Met Arg Leu Ser Gln Phe           
        75                  80                  85                        

ctg tcc gat gaa gtt ttc att gtc aat gtg acg gac cag tct ggc aac        702
Leu Ser Asp Glu Val Phe Ile Val Asn Val Thr Asp Gln Ser Gly Asn           
    90                  95                  100                           

aac tcc caa gag tgt ggc agc ttt gtc ctg gct gag agc atc aaa cca        750
Asn Ser Gln Glu Cys Gly Ser Phe Val Leu Ala Glu Ser Ile Lys Pro           
105                 110                 115                 120           

gct ccc ccc ttg aac gtg act gtg gcc ttc tca gga cgc tat gat atc        798
Ala Pro Pro Leu Asn Val Thr Val Ala Phe Ser Gly Arg Tyr Asp Ile           
                125                 130                 135               

tcc tgg gac tca gct tat gac gaa ccc tcc aac tac gtg ctg agg ggc        846
Ser Trp Asp Ser Ala Tyr Asp Glu Pro Ser Asn Tyr Val Leu Arg Gly           
            140                 145                 150                   

aag cta caa tat gag ctg cag tat cgg aac ctc aga gac ccc tat gct        894
Lys Leu Gln Tyr Glu Leu Gln Tyr Arg Asn Leu Arg Asp Pro Tyr Ala           
        155                 160                 165                       

gtg agg ccg gtg acc aag ctg atc tca gtg gac tca aga aac gtc tct        942
Val Arg Pro Val Thr Lys Leu Ile Ser Val Asp Ser Arg Asn Val Ser           
    170                 175                 180                           

ctt ctc cct gaa gag ttc cac aaa gat tct agc tac cag ctg cag gtg        990
Leu Leu Pro Glu Glu Phe His Lys Asp Ser Ser Tyr Gln Leu Gln Val           
185                 190                 195                 200           

cgg gca gcg cct cag cca ggc act tca ttc agg ggg acc tgg agt gag       1038
Arg Ala Ala Pro Gln Pro Gly Thr Ser Phe Arg Gly Thr Trp Ser Glu           
                205                 210                 215               

tgg agt gac ccc gtc atc ttt cag acc cag gct ggg gag ccc gag gca       1086
Trp Ser Asp Pro Val Ile Phe Gln Thr Gln Ala Gly Glu Pro Glu Ala           
            220                 225                 230                   

ggc tgg gac cct cac atg ctg ctg ctc ctg gct gtc ttg atc att gtc       1134
Gly Trp Asp Pro His Met Leu Leu Leu Leu Ala Val Leu Ile Ile Val           
        235                 240                 245                       

ctg gtt ttc atg ggt ctg aag atc cac ctg cct tgg agg cta tgg aaa       1182
Leu Val Phe Met Gly Leu Lys Ile His Leu Pro Trp Arg Leu Trp Lys           
    250                 255                 260                           

aag ata tgg gca cca gtg ccc acc cct gag agt ttc ttc cag ccc ctg       1230
Lys Ile Trp Ala Pro Val Pro Thr Pro Glu Ser Phe Phe Gln Pro Leu           
265                 270                 275                 280           

tac agg gag cac agc ggg aac ttc aag aaa tgg gtt aat acc cct ttc       1278
Tyr Arg Glu His Ser Gly Asn Phe Lys Lys Trp Val Asn Thr Pro Phe           
                285                 290                 295               

acg gcc tcc agc ata gag ttg gtg cca cag agt tcc aca aca aca tca       1326
Thr Ala Ser Ser Ile Glu Leu Val Pro Gln Ser Ser Thr Thr Thr Ser           
            300                 305                 310                   

gcc tta cat ctg tca ttg tat cca gcc aag gag aag aag ttc ccg ggg       1374
Ala Leu His Leu Ser Leu Tyr Pro Ala Lys Glu Lys Lys Phe Pro Gly           
        315                 320                 325                       

ctg ccg ggt ctg gaa gag caa ctg gag tgt gat gga atg tct gag cct       1422
Leu Pro Gly Leu Glu Glu Gln Leu Glu Cys Asp Gly Met Ser Glu Pro           
    330                 335                 340                           

ggt cac tgg tgc ata atc ccc ttg gca gct ggc caa gcg gtc tca gcc       1470
Gly His Trp Cys Ile Ile Pro Leu Ala Ala Gly Gln Ala Val Ser Ala           
345                 350                 355                 360           

tac agt gag gag aga gac cgg cca tat ggt ctg gtg tcc att gac aca       1518
Tyr Ser Glu Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr           
                365                 370                 375               

gtg act gtg gga gat gca gag ggc ctg tgt gtc tgg ccc tgt agc tgt       1566
Val Thr Val Gly Asp Ala Glu Gly Leu Cys Val Trp Pro Cys Ser Cys           
            380                 385                 390                   

gag gat gat ggc tat cca gcc atg aac ctg gat gct ggc cga gag tct       1614
Glu Asp Asp Gly Tyr Pro Ala Met Asn Leu Asp Ala Gly Arg Glu Ser           
        395                 400                 405                       

ggc cct aat tca gag gat ctg ctc ttg gtc aca gac cct gct ttt ctg       1662
Gly Pro Asn Ser Glu Asp Leu Leu Leu Val Thr Asp Pro Ala Phe Leu           
    410                 415                 420                           

tct tgc ggc tgt gtc tca ggt agt ggt ctc agg ctt gga ggc tcc cca       1710
Ser Cys Gly Cys Val Ser Gly Ser Gly Leu Arg Leu Gly Gly Ser Pro           
425                 430                 435                 440           

ggc agc cta ctg gac agg ttg agg ctg tca ttt gca aag gaa ggg gac       1758
Gly Ser Leu Leu Asp Arg Leu Arg Leu Ser Phe Ala Lys Glu Gly Asp           
                445                 450                 455               

tgg aca gca gac cca acc tgg aga act ggg tcc cca gga ggg ggc tct       1806
Trp Thr Ala Asp Pro Thr Trp Arg Thr Gly Ser Pro Gly Gly Gly Ser           
            460                 465                 470                   

gag agt gaa gca ggt tcc ccc cct ggt ctg gac atg gac aca ttt gac       1854
Glu Ser Glu Ala Gly Ser Pro Pro Gly Leu Asp Met Asp Thr Phe Asp           
        475                 480                 485                       

agt ggc ttt gca ggt tca gac tgt ggc agc ccc gtg gag act gat gaa       1902
Ser Gly Phe Ala Gly Ser Asp Cys Gly Ser Pro Val Glu Thr Asp Glu           
    490                 495                 500                           

gga ccc cct cga agc tat ctc cgc cag tgg gtg gtc agg acc cct cca       1950
Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Arg Thr Pro Pro           
505                 510                 515                 520           

cct gtg gac agt gga gcc cag agc agc tag catataataa ccagctatag         2000
Pro Val Asp Ser Gly Ala Gln Ser Ser                                       
                525                                                       

tgagaagagg cctctgagcc tggcatttac agtgtgaaca tgtaggggtg tgtgtgtgtg     2060

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtctt gggttgtgtg     2120

ttagcacatc catgttggga tttggtctgt tgctatgtat tgtaatgcta aattctctac     2180

ccaaagttct aggcctacga gtgaattctc atgtttacaa acttgctgtg taaaccttgt     2240

tccttaattt aataccattg gttaaataaa attggctgca accaattact ggagggatta     2300

gaggtagggg gcttttgagt tacctgtttg gagatggaga aggagagagg agagaccaag     2360

aggagaagga ggaaggagag gagaggagag gagaggagag gagaggagag gagaggagag     2420

gagaggagag gagaggctgc cgtgagggga gagggaccat gagcctgtgg ccaggagaaa     2480

cagcaagtat ctggggtaca ctggtgagga ggtggccagg ccagcagtta gaagagtaga     2540

ttaggggtga cctccagtat ttgtcaaagc caattaaaat aacaaaaaaa aaaaaaaa       2598


<210>  4
<211>  529
<212>  PRT
<213>  mus musculus

<400>  4

Met Pro Arg Gly Pro Val Ala Ala Leu Leu Leu Leu Ile Leu His Gly 
1               5                   10                  15      


Ala Trp Ser Cys Leu Asp Leu Thr Cys Tyr Thr Asp Tyr Leu Trp Thr 
            20                  25                  30          


Ile Thr Cys Val Leu Glu Thr Arg Ser Pro Asn Pro Ser Ile Leu Ser 
        35                  40                  45              


Leu Thr Trp Gln Asp Glu Tyr Glu Glu Leu Gln Asp Gln Glu Thr Phe 
    50                  55                  60                  


Cys Ser Leu His Arg Ser Gly His Asn Thr Thr His Ile Trp Tyr Thr 
65                  70                  75                  80  


Cys His Met Arg Leu Ser Gln Phe Leu Ser Asp Glu Val Phe Ile Val 
                85                  90                  95      


Asn Val Thr Asp Gln Ser Gly Asn Asn Ser Gln Glu Cys Gly Ser Phe 
            100                 105                 110         


Val Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Leu Asn Val Thr Val 
        115                 120                 125             


Ala Phe Ser Gly Arg Tyr Asp Ile Ser Trp Asp Ser Ala Tyr Asp Glu 
    130                 135                 140                 


Pro Ser Asn Tyr Val Leu Arg Gly Lys Leu Gln Tyr Glu Leu Gln Tyr 
145                 150                 155                 160 


Arg Asn Leu Arg Asp Pro Tyr Ala Val Arg Pro Val Thr Lys Leu Ile 
                165                 170                 175     


Ser Val Asp Ser Arg Asn Val Ser Leu Leu Pro Glu Glu Phe His Lys 
            180                 185                 190         


Asp Ser Ser Tyr Gln Leu Gln Val Arg Ala Ala Pro Gln Pro Gly Thr 
        195                 200                 205             


Ser Phe Arg Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 
    210                 215                 220                 


Thr Gln Ala Gly Glu Pro Glu Ala Gly Trp Asp Pro His Met Leu Leu 
225                 230                 235                 240 


Leu Leu Ala Val Leu Ile Ile Val Leu Val Phe Met Gly Leu Lys Ile 
                245                 250                 255     


His Leu Pro Trp Arg Leu Trp Lys Lys Ile Trp Ala Pro Val Pro Thr 
            260                 265                 270         


Pro Glu Ser Phe Phe Gln Pro Leu Tyr Arg Glu His Ser Gly Asn Phe 
        275                 280                 285             


Lys Lys Trp Val Asn Thr Pro Phe Thr Ala Ser Ser Ile Glu Leu Val 
    290                 295                 300                 


Pro Gln Ser Ser Thr Thr Thr Ser Ala Leu His Leu Ser Leu Tyr Pro 
305                 310                 315                 320 


Ala Lys Glu Lys Lys Phe Pro Gly Leu Pro Gly Leu Glu Glu Gln Leu 
                325                 330                 335     


Glu Cys Asp Gly Met Ser Glu Pro Gly His Trp Cys Ile Ile Pro Leu 
            340                 345                 350         


Ala Ala Gly Gln Ala Val Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro 
        355                 360                 365             


Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Gly Asp Ala Glu Gly 
    370                 375                 380                 


Leu Cys Val Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala Met 
385                 390                 395                 400 


Asn Leu Asp Ala Gly Arg Glu Ser Gly Pro Asn Ser Glu Asp Leu Leu 
                405                 410                 415     


Leu Val Thr Asp Pro Ala Phe Leu Ser Cys Gly Cys Val Ser Gly Ser 
            420                 425                 430         


Gly Leu Arg Leu Gly Gly Ser Pro Gly Ser Leu Leu Asp Arg Leu Arg 
        435                 440                 445             


Leu Ser Phe Ala Lys Glu Gly Asp Trp Thr Ala Asp Pro Thr Trp Arg 
    450                 455                 460                 


Thr Gly Ser Pro Gly Gly Gly Ser Glu Ser Glu Ala Gly Ser Pro Pro 
465                 470                 475                 480 


Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Ala Gly Ser Asp Cys 
                485                 490                 495     


Gly Ser Pro Val Glu Thr Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg 
            500                 505                 510         


Gln Trp Val Val Arg Thr Pro Pro Pro Val Asp Ser Gly Ala Gln Ser 
        515                 520                 525             


Ser 
    


<210>  5
<211>  551
<212>  PRT
<213>  homo sapiens

<400>  5

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
    130                 135                 140                 


Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr 
145                 150                 155                 160 


Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His 
                165                 170                 175     


Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp 
            180                 185                 190         


Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val 
        195                 200                 205             


Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser 
    210                 215                 220                 


Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr 
225                 230                 235                 240 


Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
                245                 250                 255     


Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro 
            260                 265                 270         


Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe 
        275                 280                 285             


Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu 
    290                 295                 300                 


Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro 
305                 310                 315                 320 


Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu 
                325                 330                 335     


Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn 
            340                 345                 350         


His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His 
        355                 360                 365             


Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr 
    370                 375                 380                 


Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro 
385                 390                 395                 400 


Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp 
                405                 410                 415     


Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro 
            420                 425                 430         


Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser 
        435                 440                 445             


Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro 
    450                 455                 460                 


Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro 
465                 470                 475                 480 


Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala 
                485                 490                 495     


Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro 
            500                 505                 510         


Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg 
        515                 520                 525             


Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly 
    530                 535                 540                 


Gln Asp Pro Thr His Leu Val 
545                 550     


<210>  6
<211>  16
<212>  PRT
<213>  Apis mellifera

<400>  6

Met Pro Leu Leu Leu Leu Leu Leu Leu Leu Pro Ser Pro Leu His Pro 
1               5                   10                  15      


<210>  7
<211>  224
<212>  PRT
<213>  homo sapiens

<400>  7

His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Leu Gly Ala Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Val Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220                 


<210>  8
<211>  611
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (41)..(529)

<400>  8
gtgaaaacga gaccaaggtc tagctctact gttggtactt atg aga tcc agt cct         55
                                            Met Arg Ser Ser Pro           
                                            1               5             

ggc aac atg gag agg att gtc atc tgt ctg atg gtc atc ttc ttg ggg        103
Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met Val Ile Phe Leu Gly           
                10                  15                  20                

aca ctg gtc cac aaa tca agc tcc caa ggt caa gat cgc cac atg att        151
Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met Ile           
            25                  30                  35                    

aga atg cgt caa ctt ata gat att gtt gat cag ctg aaa aat tat gtg        199
Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val           
        40                  45                  50                        

aat gac ttg gtc cct gaa ttt ctg cca gct cca gaa gat gta gag aca        247
Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr           
    55                  60                  65                            

aac tgt gag tgg tca gct ttt tcc tgc ttt cag aag gcc caa cta aag        295
Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys           
70                  75                  80                  85            

tca gca aat aca gga aac aat gaa agg ata atc aat gta tca att aaa        343
Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys           
                90                  95                  100               

aag ctg aag agg aaa cca cct tcc aca aat gca ggg aga aga cag aaa        391
Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys           
            105                 110                 115                   

cac aga cta aca tgc cct tca tgt gat tct tat gag aaa aaa cca ccc        439
His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro           
        120                 125                 130                       

aaa gaa ttc cta gaa aga ttc aaa tca ctt ctc caa aag atg att cat        487
Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His           
    135                 140                 145                           

cag cat ctg tcc tct aga aca cac gga agt gaa gat tcc tga                529
Gln His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser                       
150                 155                 160                               

ggatctaact tgcagttgga cactatgtta catactctaa tatagtagtg aaagtcattt      589

ctttgtattc caagtggagg ag                                               611


<210>  9
<211>  162
<212>  PRT
<213>  homo sapiens

<400>  9

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser 
        


<210>  10
<211>  3072
<212>  DNA
<213>  mus musculus


<220>
<221>  CDS
<222>  (54)..(494)

<400>  10
gagaaccaga ccaaggccct gtcatcagct cctggagact cagttctggt ggc atg          56
                                                           Met            
                                                           1              

gag agg acc ctt gtc tgt ctg gta gtc atc ttc ttg ggg aca gtg gcc        104
Glu Arg Thr Leu Val Cys Leu Val Val Ile Phe Leu Gly Thr Val Ala           
            5                   10                  15                    

cat aaa tca agc ccc caa ggg cca gat cgc ctc ctg att aga ctt cgt        152
His Lys Ser Ser Pro Gln Gly Pro Asp Arg Leu Leu Ile Arg Leu Arg           
        20                  25                  30                        

cac ctt att gac att gtt gaa cag ctg aaa atc tat gaa aat gac ttg        200
His Leu Ile Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp Leu           
    35                  40                  45                            

gat cct gaa ctt cta tca gct cca caa gat gta aag ggg cac tgt gag        248
Asp Pro Glu Leu Leu Ser Ala Pro Gln Asp Val Lys Gly His Cys Glu           
50                  55                  60                  65            

cat gca gct ttt gcc tgt ttt cag aag gcc aaa ctc aag cca tca aac        296
His Ala Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser Asn           
                70                  75                  80                

cct gga aac aat aag aca ttc atc att gac ctc gtg gcc cag ctc agg        344
Pro Gly Asn Asn Lys Thr Phe Ile Ile Asp Leu Val Ala Gln Leu Arg           
            85                  90                  95                    

agg agg ctg cct gcc agg agg gga gga aag aaa cag aag cac ata gct        392
Arg Arg Leu Pro Ala Arg Arg Gly Gly Lys Lys Gln Lys His Ile Ala           
        100                 105                 110                       

aaa tgc cct tcc tgt gat tcg tat gag aaa agg aca ccc aaa gaa ttc        440
Lys Cys Pro Ser Cys Asp Ser Tyr Glu Lys Arg Thr Pro Lys Glu Phe           
    115                 120                 125                           

cta gaa aga cta aaa tgg ctc ctt caa aag atg att cat cag cat ctc        488
Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His Leu           
130                 135                 140                 145           

tcc tag aacacatagg acccgaagat tcctgaggat ccgagaagat tcccgaggac         544
Ser                                                                       
                                                                          

tgaggagacg ccggacacta tagacgctca cgaatgcagg agtacatctt gcctcttggg      604

attgcaagtg gagaagtacg atacgttatg ataagaacaa ctcagaaaag ctataggtta      664

agatcctttc gcccattaac taagcagaca ttgtggttcc ctgcacagac tccatgctgt      724

caacatggaa aatctcaact caacaagagc ccagcttccc gtgtcaggga tttctggtgc      784

ttctcaagct gtggcttcat cttattgccc aactgtgaca ttctttgatt ggaaggggaa      844

aactaaagct tttagcaaaa atacagctag ggaatttgtc gatctgcgag agtaagacct      904

cttatgatcc taacggaatg atgtaagctg gaaataataa gcataagatg aaattgaaaa      964

ttgaagtctt tattctttaa gaaaaacttt gtacttgaaa gcatgtctga agagtttact     1024

cattaccaca aacatctagc atattgataa ctaacatctt tatactctac aagagaggct     1084

ttccagatag gtacagtttt tcttctctat taggtctatc aaaatttaac ctattatgag     1144

ggtcacccct ggctttcact gtttttctaa agaggcaagg gtgtagtaag aagcaggctt     1204

aagttgcctt cctcccaatg tcaagttcct ttataagcta atagtttaat cttgtgaaga     1264

tggcaatgaa agcctgtgga agtgcaaacc tcactatctt ctggagccaa gtagaatttt     1324

caagtttgta gctctcacct caagtggtta tgggtgtcct gtgatgaatc tgctagctcc     1384

agcctcagtc tcctctccca catcctttcc tttctttcct ctttgaaact tctaagaaaa     1444

agcaatccaa acaagttcag cacttaagac acattgcatg cacacttttg ataagttaaa     1504

tccaaccatc tatttaaaat caaaatcagg agatgagcca agagaccaga ggttctgttc     1564

cagttttaaa cagactttta ctgaacatcc caatctttta accacagagg ctaaattgag     1624

caaatagttt tgccatttga tataatttcc aacagtatgt ttcaatgtca agttaaaaag     1684

tctacaaagc tattttccct ggagtggtat catcgctttg agaatttctt atggttaaaa     1744

tggatctgag atccaagcat ggcctggggg atggttttga tctaaggaaa aaggtgtctg     1804

tacctcacag tgcctttaaa acaagcagag atcccgtgta ccgccctaag atagcacaga     1864

ctagtgttaa ctgattccca gaaaagtgtc acaatcagaa ccaacgcatt ctcttaaact     1924

ttaaaaatat gtattgcaaa gaacttgtgt aactgtaaat gtgtgactgt tgatgacatt     1984

atacacacat agcccacgta agtgtccaat ggtgctagca ttggttgctg agtttgctgc     2044

tcgaaagctg aagcagagat gcagtccttc acaaagcaat gatggacaga gaggggagtc     2104

tccatgtttt attcttttgt tgtttctggc tgtgtaactg ttgacttctt gacattgtga     2164

tttttatatt taagacaatg tatttatttt ggtgtgttta ttgttctagc cttttaaatc     2224

actgacaatt tctaatcaag aagtacaaat aattcaatgc agcacaggct aagagcttgt     2284

atcgtttgga aaagccagtg aaggcttctc cactagccat gggaaagcta cgctttagag     2344

taaactagac aaaattgcac agcagtcttg aacctctctg tgctcaagac tcagccagtc     2404

ctttgacatt attgttcact gtgggtggga acacattgga cctgacacac tgttgtgtgt     2464

ccatgaaggt tgccactggt gtaagctttt tttggttttc attctcttat ctgtagaaca     2524

agaatgtggg gctttcctaa gtctattctg tattttattc tgaacttcgt atgtctgagt     2584

tttaatgttt tgagtactct tacaggaaca cctgaccaca cttttgagtt aaattttatc     2644

ccaagtgtga tatttagttg ttcaaaaagg gaagggatat acatacatac atacatacat     2704

acatacatat atatatatat atatacatat atatatatat atatatgtat atatatatat     2764

atatagagag agagagagag agagagagag aaagagagag aggttgttgt aggtcatagg     2824

agttcagagg aaatcagtta tggccgttaa tactgtagct gaaagtgttt tctttgtgaa     2884

taaattcata gcattattga tctatgttat tgctctgttt tatttacagt cacacctgag     2944

aatttagttt taatatgaat gatgtacttt ataacttaat gattatttat tatgtatttg     3004

gttttgaatg tttgtgttca tggcttctta tttaagacct gatcatatta aatgctaccc     3064

agtcagaa                                                              3072


<210>  11
<211>  146
<212>  PRT
<213>  mus musculus

<400>  11

Met Glu Arg Thr Leu Val Cys Leu Val Val Ile Phe Leu Gly Thr Val 
1               5                   10                  15      


Ala His Lys Ser Ser Pro Gln Gly Pro Asp Arg Leu Leu Ile Arg Leu 
            20                  25                  30          


Arg His Leu Ile Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp 
        35                  40                  45              


Leu Asp Pro Glu Leu Leu Ser Ala Pro Gln Asp Val Lys Gly His Cys 
    50                  55                  60                  


Glu His Ala Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser 
65                  70                  75                  80  


Asn Pro Gly Asn Asn Lys Thr Phe Ile Ile Asp Leu Val Ala Gln Leu 
                85                  90                  95      


Arg Arg Arg Leu Pro Ala Arg Arg Gly Gly Lys Lys Gln Lys His Ile 
            100                 105                 110         


Ala Lys Cys Pro Ser Cys Asp Ser Tyr Glu Lys Arg Thr Pro Lys Glu 
        115                 120                 125             


Phe Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His 
    130                 135                 140                 


Leu Ser 
145     


<210>  12
<211>  441
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  CDS
<222>  (1)..(441)

<400>  12
atg gag agg acc ctt gtc tgt ctg ata ctc atc ttc ttg ggg acc gtg         48
Met Glu Arg Thr Leu Val Cys Leu Ile Leu Ile Phe Leu Gly Thr Val           
1               5                   10                  15                

gcc cat aaa tca agc ccc caa agg cca gat cac ctt ctg att aga ctt         96
Ala His Lys Ser Ser Pro Gln Arg Pro Asp His Leu Leu Ile Arg Leu           
            20                  25                  30                    

cgt cac ctt atg gac att gtt gaa cag ctg aaa atc tat gag aat gac        144
Arg His Leu Met Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp           
        35                  40                  45                        

ttg gat cct gaa ctt cta aca gct cca caa gat gta aag ggg caa tgt        192
Leu Asp Pro Glu Leu Leu Thr Ala Pro Gln Asp Val Lys Gly Gln Cys           
    50                  55                  60                            

gag cac gaa gct ttt gcc tgt ttt cag aaa gcc aaa ctc aag cca tca        240
Glu His Glu Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser           
65                  70                  75                  80            

aac act gga aac aat aag aca ttc atc aac gac ttg ttg gca cag ctg        288
Asn Thr Gly Asn Asn Lys Thr Phe Ile Asn Asp Leu Leu Ala Gln Leu           
                85                  90                  95                

agg agg agg ctg cct gct aag agg aca gga aat aaa cag agg cac atg        336
Arg Arg Arg Leu Pro Ala Lys Arg Thr Gly Asn Lys Gln Arg His Met           
            100                 105                 110                   

gct aaa tgc cct tcc tgt gat ttg tat gag aaa aaa aca ccc aaa gaa        384
Ala Lys Cys Pro Ser Cys Asp Leu Tyr Glu Lys Lys Thr Pro Lys Glu           
        115                 120                 125                       

ttc ctt gaa aga cta aaa tgg ctc ctt caa aag atg att cat cag cat        432
Phe Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His           
    130                 135                 140                           

ctt tcc tag                                                            441
Leu Ser                                                                   
145                                                                       


<210>  13
<211>  146
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Glu Arg Thr Leu Val Cys Leu Ile Leu Ile Phe Leu Gly Thr Val 
1               5                   10                  15      


Ala His Lys Ser Ser Pro Gln Arg Pro Asp His Leu Leu Ile Arg Leu 
            20                  25                  30          


Arg His Leu Met Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp 
        35                  40                  45              


Leu Asp Pro Glu Leu Leu Thr Ala Pro Gln Asp Val Lys Gly Gln Cys 
    50                  55                  60                  


Glu His Glu Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser 
65                  70                  75                  80  


Asn Thr Gly Asn Asn Lys Thr Phe Ile Asn Asp Leu Leu Ala Gln Leu 
                85                  90                  95      


Arg Arg Arg Leu Pro Ala Lys Arg Thr Gly Asn Lys Gln Arg His Met 
            100                 105                 110         


Ala Lys Cys Pro Ser Cys Asp Leu Tyr Glu Lys Lys Thr Pro Lys Glu 
        115                 120                 125             


Phe Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His 
    130                 135                 140                 


Leu Ser 
145     


<210>  14
<211>  473
<212>  PRT
<213>  artificial sequence

<220>
<223>  IL-21R fusion protein (Fc fusion)

<400>  14

Met Pro Arg Gly Pro Val Ala Ala Leu Leu Leu Leu Ile Leu His Gly 
1               5                   10                  15      


Ala Trp Ser Cys Leu Asp Leu Thr Cys Tyr Thr Asp Tyr Leu Trp Thr 
            20                  25                  30          


Ile Thr Cys Val Leu Glu Thr Arg Ser Pro Asn Pro Ser Ile Leu Ser 
        35                  40                  45              


Leu Thr Trp Gln Asp Glu Tyr Glu Glu Leu Gln Asp Gln Glu Thr Phe 
    50                  55                  60                  


Cys Ser Leu His Arg Ser Gly His Asn Thr Thr His Ile Trp Tyr Thr 
65                  70                  75                  80  


Cys His Met Arg Leu Ser Gln Phe Leu Ser Asp Glu Val Phe Ile Val 
                85                  90                  95      


Asn Val Thr Asp Gln Ser Gly Asn Asn Ser Gln Glu Cys Gly Ser Phe 
            100                 105                 110         


Val Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Leu Asn Val Thr Val 
        115                 120                 125             


Ala Phe Ser Gly Arg Tyr Asp Ile Ser Trp Asp Ser Ala Tyr Asp Glu 
    130                 135                 140                 


Pro Ser Asn Tyr Val Leu Arg Gly Lys Leu Gln Tyr Glu Leu Gln Tyr 
145                 150                 155                 160 


Arg Asn Leu Arg Asp Pro Tyr Ala Val Arg Pro Val Thr Lys Leu Ile 
                165                 170                 175     


Ser Val Asp Ser Arg Asn Val Ser Leu Leu Pro Glu Glu Phe His Lys 
            180                 185                 190         


Asp Ser Ser Tyr Gln Leu Gln Val Arg Ala Ala Pro Gln Pro Gly Thr 
        195                 200                 205             


Ser Phe Arg Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 
    210                 215                 220                 


Thr Gln Ala Gly Glu Pro Glu Ala Gly Trp Asp Gly Ser Gly Ser Arg 
225                 230                 235                 240 


Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
                245                 250                 255     


Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            260                 265                 270         


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    290                 295                 300                 


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
305                 310                 315                 320 


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                325                 330                 335     


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            340                 345                 350         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        355                 360                 365             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    370                 375                 380                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
385                 390                 395                 400 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                405                 410                 415     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            420                 425                 430         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        435                 440                 445             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    450                 455                 460                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
465                 470             


<210>  15
<211>  5
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Trp Ser Xaa Trp Ser 
1               5   


<210>  16
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  PLP peptide

<400>  16

His Ser Leu Gly Lys Trp Leu Gly His Pro Asp Lys Phe 
1               5                   10              


<210>  17
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  TNF primer (forward) - mouse

<400>  17
atgagaagtt cccaaatggc                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  TNF primer (reverse) - mouse

<400>  18
ctccacttgg tggtttgcta                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  IL-10 primer (forward) - mouse

<400>  19
acagccggga agacaataac                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  IL-10 primer (reverse) -  mouse

<400>  20
cagctggtcc tttgtttgaa                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  IL-17A primer (forward) - mouse

<400>  21
cctccagaat gtgaaggtca                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  IL-17A primer (reverse) -  mouse

<400>  22
ctatcagggt cttcattgcg                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  HPRT primer (forward) - mouse

<400>  23
agcctaagat gagcgcaagt                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  HPRT primer (reverse) - mouse

<400>  24
ttactaggca gatggccaca                                                   20


<210>  25
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker for fusion protein

<400>  25

Ser Gly Gly Gly Gly 
1               5   


<210>  26
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  MOG peptide

<400>  26

Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys 
            20      


<210>  27
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  IFN-gamma primer (forward) - mouse

<400>  27
agctcttcct catggctgtt                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  IFN-gamma primer (reverse) - mouse

<400>  28
tttgccagtt cctccagata                                                   20


