                         SEQUENCE LISTING

<110>  DiMarchi, et al.
 
<120>  Ester Based Peptide Prodrugs

<130>  31135/43851

<150>  US-61/024,672
<151>  2008-01-30

<160>  1118  

<170>  PatentIn version 3.5

<210>  1                 
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  2
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Arg, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  2

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Xaa Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  3
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  3

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  4
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  4

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  5
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  5

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  6
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  6

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  7
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  7

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  8
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<400>  8

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  9
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  9

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  10
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  10

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  11
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  11

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  12
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  lactam ring between side chains at position 12 and 16

<400>  12

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  13
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  lactam ring between side chains at positions 16 and 20

<400>  13

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  14
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  lactam ring between side chains at positions 22 and 24

<400>  14

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  15
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  lactam ring formed between side chains at positions 24 and 28

<400>  15

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  16
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  lactam ring between side chains at positions 12 and 16 as well as
       20 and 24

<400>  16

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  17
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  lactam ring between side chains at positions 16 and 20 as well as
       24 and 28

<400>  17

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Asp Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  18
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  Lactam ring formed between side chain of Glu at position 16 and 
       Lys at position 20

<400>  18

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  19
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Variable amino acid

<400>  19

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Xaa 
            20                  25                  30  


<210>  20
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn or Citrulline

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Asp or Lys

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  20

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  21
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ser, Ala, Gly, N-methyl Ser or aminoisobutyric acid

<400>  21

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  22
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  aminoisobutyric acid

<400>  22

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  23
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  23

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  24
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  24

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  25
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  25

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 10 
       amino acids Exendin-4

<400>  26

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 8 
       amino acids of oxyntomodulin

<400>  27

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  28
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  28

Lys Arg Asn Arg 
1               


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 10 
       amino acids of Exendin-4


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  29

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  30
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  30

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  31
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  31

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  32
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  32

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg 
    


<210>  33
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly or an acidic amino acid

<400>  33

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  34
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Asp or Lys

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  34

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  35
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  35

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  36
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  36

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  37
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  2-butyrolactone bound through thiol group of Cys

<400>  37

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  38
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  carboxymethyl group bound through thiol group of Cys

<400>  38

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  39
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  39

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  40
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Glu or Asp

<400>  40

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  41
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Glu or Asp

<400>  41

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  42
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Glu or Asp

<400>  42

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  43
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 20
       and 24

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Glu or Asp

<400>  43

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Xaa Thr 
            20                  25                  


<210>  44
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 24
       and 28

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Glu or Thr

<400>  44

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Xaa 
            20                  25                  


<210>  45
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Lys or Glu

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Gln, Glu, Lys, homoglutamic acid, cysteic acid or 
       homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Glu or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Lys or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly or an acidic amino acid

<400>  45

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  46
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<400>  46

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  47
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  47

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  48
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  48

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  49
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  49

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  50
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  50

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  51
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn, or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Glu, homoglutamic acid, or homocysteic acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly or an acidic amino acid

<400>  51

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  52
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  52

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  53
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Glu, Orn or Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or an acidic amino acid

<400>  53

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  54
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Arg or Gln

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Arg or Ala

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp or Glu

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Ala

<400>  54

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Xaa Xaa Ala Lys Xaa Phe Xaa Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  55
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His or
       alpha, alpha-dimethyl imidiazole acetic acid (DMIA), N-methyl 
       His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, aminoisobutyric 
       acid (AIB) or N-methyl Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Tyr or Trp

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Lys, Citrulline, Orn or Arg

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Arg, Gln, Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Arg, Ala, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Lys, Cys, Orn, homocystein or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln, Glu, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Arg, Citrulline, Orn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocycsteine or acetyl phenyalanine

<400>  55

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  56
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Cys, Orn, homocycstein or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln, Glu, Cys, Orn, homocycsteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocycsteine or acetyl phenyalanine

<400>  56

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  57
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  lactam ring between side changes at position 12 and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl- His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Cys, Orn, homocycsteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln, Glu, Lys, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<400>  57

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  58
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln, Glu, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<400>  58

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Lys Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  59
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  lactam ring between side chains at position 20 and 24

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB, or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl pheylalanine

<400>  59

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Lys Xaa Phe Xaa Glu Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  60
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  lactam ring between side chains at position 24 and 28

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn, or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<400>  60

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Xaa Glu Trp Leu Xaa Lys Xaa 
            20                  25                  


<210>  61
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  positions 30 to 40 are present only if position 29 is Gly; see 
       specification as filed for detailed description of substitutions 
       and preferred embodiments

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, Val, Gly, N-methyl Ser, Aib, N-methyl, Ala or 
       D-Ala

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Ala or Arg

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln or Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr-CONH2, Cys-PEG, or Gly

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG or not present

<400>  61

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Xaa Ala Lys Asp Phe Val Xaa Trp Leu Met Asn Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  62
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  positions 30 to 40 are present only if position 29 is Gly; see 
       specification as filed for detailed description of substitutions 
       and preferred embodiments

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, Val, Gly, N-methyl Ser, AIB0, N-methyl Ala, or 
       D-Ala

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Ala or Arg

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln or Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr-CONH2, Cys-PEG, or Gly

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG or not present

<400>  62

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Xaa Ala Lys Glu Phe Ile Xaa Trp Leu Met Asn Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  63
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Lys, Cys, Orn, homocysteine or acetyl phealanine

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Lys, Cys, Orn, homocysteine or acetyl phealanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  63

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  64
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<400>  64

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Pro Pro Pro Ser 
        35              


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 10 
       amino acids of Exdendin-4


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Cys-PEG

<400>  65

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Cys 
1               5                   10      


<210>  66
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asp or Asn

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  66

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  67
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asp or Asn

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  67

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  68
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  lactam ring between side chains at positions 20 and 24

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asp or Asn

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  68

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  69
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<223>  lactam ring between side chains at positions24 and 28

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  69

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Xaa 
            20                  25                  


<210>  70
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  70

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  71
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  71

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  72
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  72

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  73
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  73

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  74
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  74

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  75
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  75

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  76
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  76

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  77
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  77

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  78
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  78

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  79
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  79

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  80
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  80

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  81
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  81

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  82
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  82

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  83
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  83

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  84
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  84

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  85
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  85

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  86
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  86

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  87
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  87

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  88
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  88

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  89
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  89

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  90
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  90

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  91
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  91

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  92
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  92

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  93
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  c-term amidation

<400>  93

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  94
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  94

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  95
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  95

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  96
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  96

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  97
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  97

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  98
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  98

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  99
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  99

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  100
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  100

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  101
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  101

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  102
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  102

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  103
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  103

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  104
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  c-term amidation

<400>  104

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  105
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  105

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  106
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  106

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  107
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  107

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  108
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisebutyric acid

<400>  108

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  109
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  109

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  110
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  110

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  111
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  111

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  112
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic acid

<400>  112

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  113
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic acid

<400>  113

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  114
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic acid

<400>  114

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  115
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  115

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  116
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic acid

<400>  116

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  117
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic acid

<400>  117

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  118
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  118

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  119
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  119

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  120
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  120

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  121
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  121

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  122
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  122

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  123
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  123

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  124
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  124

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  125
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  125

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  126
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  126

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  127
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  127

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  128
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  128

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  129
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  129

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  130
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  130

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  131
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  131

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  132
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  132

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  133
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  133

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  134
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  134

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  135
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  135

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  136
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  136

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  137
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  137

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  138
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  138

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  139
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  139

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  140
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  140

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  141
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  141

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  142
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  142

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  143
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  143

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  144
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  144

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  145
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  145

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  146
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  146

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  147
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  147

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  148
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  148

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  149
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  149

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  150
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  150

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  151
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  151

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  152
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  152

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  153
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  153

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  154
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  154

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  155
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  155

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  156
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  156

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  157
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  157

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  158
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  158

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  159
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  159

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  160
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  160

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  161
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  161

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  162
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  162

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  163
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  163

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  164
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  164

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  165
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  165

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  166
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  166

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  167
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  167

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  168
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  168

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  169
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  169

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  170
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  170

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  171
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  171

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  172
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  172

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  173
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  173

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  174
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  174

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  175
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  175

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  176
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  176

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  177
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  177

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  178
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  178

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  179
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  179

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  180
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  180

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  181
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  181

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  182
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  182

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  183
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  183

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  184
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  184

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  185
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  185

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  186
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  186

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  187
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  187

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  188
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  188

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  189
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  189

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  190
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  190

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  191
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  191

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  192
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  192

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  193
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  193

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  194
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  194

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  195
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  195

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  196
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  196

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  197
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  197

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  198
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  198

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  199
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  199

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  200
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  200

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  201
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  201

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  202
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  202

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  203
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  203

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  204
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  204

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  205
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  205

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  206
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  206

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  207
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  207

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  208
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  208

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  209
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  209

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  210
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  210

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  211
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  211

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  212
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  212

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  213
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  213

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  214
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  214

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  215
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  215

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  216
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  216

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  217
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  217

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  218
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  218

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  219
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  219

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  220
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  220

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  221
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  221

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  222
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  222

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  223
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  223

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  224
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  224

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  225
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  225

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  226
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  226

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  227
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  227

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  228
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  228

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  229
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  229

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  230
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  230

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  231
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys0PEG

<400>  231

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  232
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  232

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  233
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  233

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  234
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  234

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  235
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  235

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  236
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  236

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  237
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  237

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  238
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  238

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  239
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  239

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  240
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  240

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  241
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  241

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  242
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  242

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  243
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  243

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  244
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  244

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  245
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  245

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  246
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  246

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  247
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  247

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  248
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  248

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  249
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  249

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  250
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  250

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  251
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  251

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  252
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  252

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  253
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  253

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  254
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  254

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  255
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  255

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  256
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  256

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  257
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  257

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  258
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  258

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  259
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  259

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  260
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chrains at positions 
       12 and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  260

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  261
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  261

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  262
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  262

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  263
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  263

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  264
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  264

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  265
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  265

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  266
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring betwee side chains at positions 12 
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  266

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  267
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  267

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  268
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  268

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  269
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring betwee side chains at positions 12 
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  269

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  270
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring betwee side chains at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  270

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  271
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  271

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  272
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  272

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  273
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  273

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  274
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  274

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  275
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  275

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  276
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  276

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  277
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  277

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  278
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  278

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  279
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  279

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  280
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  280

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  281
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  281

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  282
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  282

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  283
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  283

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  284
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  284

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  285
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  285

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  286
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  286

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  287
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chain at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  287

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  288
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  288

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  289
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  289

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  290
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  290

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  291
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  291

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  292
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  292

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  293
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  293

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  294
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  294

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  295
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  295

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  296
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  296

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  297
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  297

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  298
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  298

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  299
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  299

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  300
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  300

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  301
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  301

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  302
<211>  29
<212>  PRT
<213>  Artificial Sequencce

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  302

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  303
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  303

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  304
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  304

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  305
<211>  29
<212>  PRT
<213>  Artificial Sequencce

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  305

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  306
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  306

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  307
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  307

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  308
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  308

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  309
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  309

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  310
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  310

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  311
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chain at positions 12 
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  311

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  312
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  312

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  313
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  313

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  314
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  314

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  315
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between seide chains at positions 
       16 and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  315

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  316
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  316

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  317
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       adn 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  317

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  318
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  318

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  319
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  319

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  320
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  320

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  321
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at position 16 
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  321

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  322
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  322

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  323
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  323

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  324
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at position 16 
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  324

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  325
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  325

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  326
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  326

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  327
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  327

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  328
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam between side chains at positions 12 and 
       16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  328

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  329
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  329

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  330
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  330

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  331
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  331

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  332
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  332

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  333
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  333

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  334
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  334

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  335
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chainst at positions 
       16 and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  335

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  336
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  336

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  337
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  337

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  338
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam right between side chains at positions 
       16 and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  338

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  339
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  339

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  340
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       adn 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  340

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  341
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  341

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  342
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  342

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  343
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  343

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  344
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  344

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  345
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  345

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  346
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  346

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  347
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  347

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  348
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  348

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  349
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  349

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  350
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  350

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  351
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  351

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  352
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  352

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  353
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  353

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  354
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  354

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  355
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  355

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  356
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  356

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  357
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  357

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  358
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  358

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  359
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  359

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  360
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  360

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  361
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  361

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  362
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  362

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  363
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  363

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  364
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  364

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  365
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  365

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  366
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  366

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  367
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  367

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  368
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  368

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  369
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  369

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  370
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  370

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  371
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  371

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  372
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  372

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  373
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  373

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  374
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  374

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  375
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  375

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  376
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  376

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  377
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  377

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  378
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  378

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  379
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  379

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  380
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  380

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  381
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  381

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  382
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  382

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  383
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  383

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  384
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  384

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  385
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  385

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  386
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<400>  386

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  387
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  387

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  388
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  388

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  389
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  389

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  390
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  390

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  391
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  391

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  392
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  392

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  393
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  393

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  394
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  394

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  395
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  395

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  396
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  396

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  397
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  397

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  398
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  398

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  399
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  399

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  400
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  400

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  401
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  401

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  402
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  402

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  403
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  403

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  404
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  404

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  405
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  aminoisobutyric acid

<400>  405

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  406
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  406

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  407

<400>  407
000

<210>  408

<400>  408
000

<210>  409

<400>  409
000

<210>  410

<400>  410
000

<210>  411

<400>  411
000

<210>  412

<400>  412
000

<210>  413

<400>  413
000

<210>  414

<400>  414
000

<210>  415

<400>  415
000

<210>  416

<400>  416
000

<210>  417

<400>  417
000

<210>  418

<400>  418
000

<210>  419

<400>  419
000

<210>  420

<400>  420
000

<210>  421

<400>  421
000

<210>  422

<400>  422
000

<210>  423

<400>  423
000

<210>  424

<400>  424
000

<210>  425

<400>  425
000

<210>  426

<400>  426
000

<210>  427

<400>  427
000

<210>  428

<400>  428
000

<210>  429

<400>  429
000

<210>  430

<400>  430
000

<210>  431

<400>  431
000

<210>  432

<400>  432
000

<210>  433

<400>  433
000

<210>  434

<400>  434
000

<210>  435

<400>  435
000

<210>  436

<400>  436
000

<210>  437

<400>  437
000

<210>  438

<400>  438
000

<210>  439

<400>  439
000

<210>  440

<400>  440
000

<210>  441

<400>  441
000

<210>  442

<400>  442
000

<210>  443

<400>  443
000

<210>  444

<400>  444
000

<210>  445

<400>  445
000

<210>  446

<400>  446
000

<210>  447

<400>  447
000

<210>  448

<400>  448
000

<210>  449

<400>  449
000

<210>  450

<400>  450
000

<210>  451

<400>  451
000

<210>  452

<400>  452
000

<210>  453

<400>  453
000

<210>  454

<400>  454
000

<210>  455

<400>  455
000

<210>  456

<400>  456
000

<210>  457

<400>  457
000

<210>  458

<400>  458
000

<210>  459

<400>  459
000

<210>  460

<400>  460
000

<210>  461

<400>  461
000

<210>  462

<400>  462
000

<210>  463

<400>  463
000

<210>  464

<400>  464
000

<210>  465

<400>  465
000

<210>  466

<400>  466
000

<210>  467

<400>  467
000

<210>  468

<400>  468
000

<210>  469

<400>  469
000

<210>  470

<400>  470
000

<210>  471

<400>  471
000

<210>  472

<400>  472
000

<210>  473

<400>  473
000

<210>  474

<400>  474
000

<210>  475

<400>  475
000

<210>  476

<400>  476
000

<210>  477

<400>  477
000

<210>  478

<400>  478
000

<210>  479

<400>  479
000

<210>  480

<400>  480
000

<210>  481

<400>  481
000

<210>  482

<400>  482
000

<210>  483

<400>  483
000

<210>  484

<400>  484
000

<210>  485

<400>  485
000

<210>  486

<400>  486
000

<210>  487

<400>  487
000

<210>  488

<400>  488
000

<210>  489

<400>  489
000

<210>  490

<400>  490
000

<210>  491

<400>  491
000

<210>  492

<400>  492
000

<210>  493

<400>  493
000

<210>  494

<400>  494
000

<210>  495

<400>  495
000

<210>  496

<400>  496
000

<210>  497

<400>  497
000

<210>  498

<400>  498
000

<210>  499

<400>  499
000

<210>  500

<400>  500
000

<210>  501

<400>  501
000

<210>  502

<400>  502
000

<210>  503

<400>  503
000

<210>  504

<400>  504
000

<210>  505

<400>  505
000

<210>  506

<400>  506
000

<210>  507

<400>  507
000

<210>  508

<400>  508
000

<210>  509

<400>  509
000

<210>  510

<400>  510
000

<210>  511

<400>  511
000

<210>  512

<400>  512
000

<210>  513

<400>  513
000

<210>  514

<400>  514
000

<210>  515

<400>  515
000

<210>  516

<400>  516
000

<210>  517

<400>  517
000

<210>  518

<400>  518
000

<210>  519

<400>  519
000

<210>  520

<400>  520
000

<210>  521

<400>  521
000

<210>  522

<400>  522
000

<210>  523

<400>  523
000

<210>  524

<400>  524
000

<210>  525

<400>  525
000

<210>  526

<400>  526
000

<210>  527

<400>  527
000

<210>  528

<400>  528
000

<210>  529

<400>  529
000

<210>  530

<400>  530
000

<210>  531

<400>  531
000

<210>  532

<400>  532
000

<210>  533

<400>  533
000

<210>  534
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  acylated with C8 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  c-term amidation

<400>  534

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  535
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  acylated with C14 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  c-term amidation

<400>  535

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  536
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  acylated with C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  c-term amidation

<400>  536

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  537
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  acylated with C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  c-term amidation

<400>  537

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  538
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  acylated with C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  c-term amidation

<400>  538

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  539
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  acylated with C24 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  539

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  540
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  covalently attached to a Trp residue comprising C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  540

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  541
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  covalently attached to a Trp residue comprising C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  541

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  542
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  covalent attache to C16 fatty acid

<400>  542

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  543
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  covalently attached to a Trp residue comprising C16 fatty acid

<400>  543

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  544
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  covalently attached to C18 fatty acid

<400>  544

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  545
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  545

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  546
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  covalently attached to a Trp residue comprising C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  546

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  547
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  covalently attached to a C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  547

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  548
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  covalently attached to a Trp residue comprising a C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  548

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  549
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  attached to a Glu residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  c-term amidation

<400>  549

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  550
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  550

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn 
            20                  25              


<210>  551
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  551

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met 
            20                  25          


<210>  552
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  c-term amidation

<400>  552

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn 
            20                  25              


<210>  553
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  c-term amidation

<400>  553

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met 
            20                  25          


<210>  554
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Nle

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  c-term amidation

<400>  554

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  555
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  lactam ring between side chains at positions 16 and 20

<400>  555

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  556
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  c-term amidation

<400>  556

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  557
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  c-term amidation

<400>  557

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Ile Asx Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  558
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  attached to a Trp comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  c-term amidation

<400>  558

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Ile Asx Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  559
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  559

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Ile Asx Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  560
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  attached to a Trp comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  c-term amidation

<400>  560

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Ile Asx Arg Arg Ala Ala Ile Asx Asp Phe Val Cys Trp Leu Met Asn 
            20                  25                  30          


Thr 
    


<210>  561
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  attached to a Trp comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  c-term amidation

<400>  561

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ala 
1               5                   10                  15      


Ile Asx Arg Arg Ala Ala Ile Asx Asp Phe Val Cys Trp Leu Met Asn 
            20                  25                  30          


Thr 
    


<210>  562

<400>  562
000

<210>  563

<400>  563
000

<210>  564

<400>  564
000

<210>  565

<400>  565
000

<210>  566

<400>  566
000

<210>  567

<400>  567
000

<210>  568

<400>  568
000

<210>  569

<400>  569
000

<210>  570

<400>  570
000

<210>  571

<400>  571
000

<210>  572

<400>  572
000

<210>  573

<400>  573
000

<210>  574

<400>  574
000

<210>  575

<400>  575
000

<210>  576

<400>  576
000

<210>  577

<400>  577
000

<210>  578

<400>  578
000

<210>  579

<400>  579
000

<210>  580

<400>  580
000

<210>  581

<400>  581
000

<210>  582

<400>  582
000

<210>  583

<400>  583
000

<210>  584

<400>  584
000

<210>  585

<400>  585
000

<210>  586

<400>  586
000

<210>  587

<400>  587
000

<210>  588

<400>  588
000

<210>  589

<400>  589
000

<210>  590

<400>  590
000

<210>  591

<400>  591
000

<210>  592

<400>  592
000

<210>  593

<400>  593
000

<210>  594

<400>  594
000

<210>  595

<400>  595
000

<210>  596

<400>  596
000

<210>  597

<400>  597
000

<210>  598

<400>  598
000

<210>  599

<400>  599
000

<210>  600

<400>  600
000

<210>  601
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  GLP-1 (7-37)

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  C-terminal carboxylate replaced with amide

<400>  601

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  602
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal carboxylate replaced with amide

<400>  602

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  603
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  603

Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu 
1               5                   10                  15      


Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25      


<210>  604
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  AMIDATION

<400>  604

Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu 
1               5                   10                  15      


Phe Ile Ala Trp Leu Val Lys Gly Ala Arg 
            20                  25      


<210>  605
<211>  34
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Xaa at position 25 is Arg or Gly

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  AMIDATION

<400>  605

Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu 
1               5                   10                  15      


Phe Ile Ala Trp Leu Val Lys Gly Xaa Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  606
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  606

Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu 
1               5                   10                  15      


Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Lys Arg Asn Arg Asn Asn 
            20                  25                  30          


Ile Ala 
        


<210>  607
<211>  39
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Hydroxyl group replacing the native N-terminal amine

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Xaa at position 30 is Arg or Gly

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  AMIDATION

<400>  607

Phe Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Xaa Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  608
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa at position 29 is Arg or Gly

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  AMIDATION

<400>  608

Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln 
1               5                   10                  15      


Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Xaa Pro Ser Ser 
            20                  25                  30          


Gly Ala Pro Pro Pro Ser 
        35              


<210>  609
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa at position 29 is Arg or Gly

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  AMIDATION

<400>  609

Ala Gln Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln 
1               5                   10                  15      


Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Xaa Pro Ser Ser 
            20                  25                  30          


Gly Ala Pro Pro Pro Ser 
        35              


<210>  610
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  610

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Lys 
            20                  25                  30          


Arg Asn Arg Asn Asn Ile Ala 
        35                  


<210>  611
<211>  39
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Xaa at position 30 is Arg or Gly

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  AMIDATION

<400>  611

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Xaa Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  612
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Glucagon

<400>  612

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  613
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  613

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  614
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  614

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  615
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa at position 11 is serine, glycine, glutamic acid, glutamine, 
       homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa at position 15 is Lys, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa at position 16 is Glu, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Xaa at position 19 is Ala, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<400>  615

Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Xaa Gln Ala Ala Xaa Xaa 
1               5                   10                  15      


Phe Ile Xaa Trp Leu Val Lys Gly Arg Gly 
            20                  25      


<210>  616
<211>  25
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa at position 11 is serine, glycine, glutamic acid, glutamine, 
       homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa at position 15 is Lys, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa at position 16 is Glu, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Xaa at position 19 is Ala, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<400>  616

Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Xaa Gln Ala Ala Xaa Xaa 
1               5                   10                  15      


Phe Ile Xaa Trp Leu Val Lys Gly Arg 
            20                  25  


<210>  617
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa at position 11 is serine, glycine, glutamic acid, glutamine, 
       homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa at position 15 is Lys, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa at position 16 is Glu, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Xaa at position 19 is Ala, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Xaa at position 25 is Arg or Gly

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  AMIDATION

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Xaa at position 35 is Cys, Orn, homocysteine or acetyl 
       phenyalanine

<400>  617

Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Xaa Gln Ala Ala Xaa Xaa 
1               5                   10                  15      


Phe Ile Xaa Trp Leu Val Lys Gly Xaa Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Xaa 
        35  


<210>  618
<211>  24
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa at position 11 is serine, glycine, glutamic acid, glutamine, 
       homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa at position 15 is Gln, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa at position 16 is Asp, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Xaa at position 19 is Gln, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<400>  618

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Xaa Xaa 
1               5                   10                  15      


Phe Val Xaa Trp Leu Met Asn Thr 
            20                  


<210>  619
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa at position 11 is serine, glycine, glutamic acid, glutamine, 
       homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa at position 15 is Gln, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa at position 16 is Asp, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Xaa at position 19 is Gln, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  AMIDATION

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Xaa at position 35 is Cys, Orn, homocysteine or acetyl 
       phenyalanine

<400>  619

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Xaa Xaa 
1               5                   10                  15      


Phe Val Xaa Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Xaa 
        35  


<210>  620
<211>  34
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  AMIDATION

<400>  620

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  621
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine, desaminohistidine, 
       homo-histidine, tyrosine or phenylalanine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is glycine, alanine, serine, valine, d-alanine,
       aminoisobutyric acid, or N-methyl alanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa at position 3 is glutamic acid, aspartic acid, glutamine or 
       asparagine

<400>  621

Xaa Xaa Xaa Gly 
1               


<210>  622
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine, desaminohistidine, 
       homo-histidine, tyrosine or phenylalanine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is glycine, alanine, serine, valine, D-alanine,
       aminoisobutyric acid, or N-methyl alanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa at position 3 is glutamic acid, aspartic acid, glutamine or 
       asparagine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa at position 5 is threonine or serine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa at position 8 is threonine or serine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa at position 11 is threonine or serine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa at position 16 is glycine, glutamic acid, glutamine, 
       homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa at position 20 is Lys, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa at position 21is Glu, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa at position 24 is Ala, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<400>  622

Xaa Xaa Xaa Gly Xaa Phe Thr Xaa Asp Val Xaa Ser Tyr Leu Glu Xaa 
1               5                   10                  15      


Gln Ala Ala Xaa Xaa Phe Ile Xaa Trp Leu Val Lys Gly 
            20                  25                  


<210>  623
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine, desaminohistidine, 
       homo-histidine, tyrosine or phenylalanine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is glycine, alanine, serine, valine, D-alanine,
       aminoisobutyric acid, N-methyl alanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa at position 3 is glutamic acid, aspartic acid, glutamine or 
       asparagine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa at position 5 is serine or threonine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa at position 8 is serine or threonine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa at position 8 is serine or threonine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa at position 16 is serine, glycine, glutamic acid, glutamine, 
       homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa at position 20 is Gln, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa at position 21 is Asp, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa at position 24 is Gln, Cys, Orn, homocysteine or acetyl 
       phenyalanine

<400>  623

Xaa Xaa Xaa Gly Xaa Phe Thr Xaa Asp Tyr Xaa Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Val Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  624
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  624

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  625
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  625

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  626
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa at position 1 is Gly or desamino-Gly

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa at position 4 is Glu Ser or Thr

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa at position 8 is Thr, His, Arg or Lys

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa at position 21 is Asn, Ser, Thr or Gly

<400>  626

Xaa Ile Val Xaa Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Xaa 
            20      


<210>  627
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa at position 1 is Phe or desamino-Phe

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa at position 5 is His, Thr or Ser

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa at position 9 is Thr or Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa at position 10 is Asp, Glu, homocysteic acid or cysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa at position 16 is Tyr or  4-hydroxymethyl Phe

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Xaa at position 25 is Tyr, Phe or  4-hydroxymethyl Phe

<400>  627

Xaa Val Asn Gln Xaa Leu Cys Gly Xaa Xaa Leu Val Glu Ala Leu Xaa 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Xaa Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  628
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa at position 1 is His, Thr or Ser

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa at position 5 is Thr or Ser

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa at position 6 is Asp, Glu, homocysteic acid or cysteic acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa at position 12 is Tyr or  4-hydroxymethyl Phe

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa at position 21 is Tyr, Phe or  4-hydroxymethyl Phe

<400>  628

Xaa Leu Cys Gly Xaa Xaa Leu Val Glu Ala Leu Xaa Leu Val Cys Gly 
1               5                   10                  15      


Glu Arg Gly Phe Xaa 
            20      


<210>  629
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  629

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  630
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  630

Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln 
1               5                   10                  15      


Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25              


<210>  631
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  631

Ala Gln Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln 
1               5                   10                  15      


Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25              


<210>  632
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  632

Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg 
1               5                   10                  15      


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25              


<210>  633
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  AMIDATION

<400>  633

Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg 
1               5                   10                  15      


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser 
            20                  25                  30          


Gly Ala Pro Pro Pro Ser 
        35              


<210>  634
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa at position 1 is desaminohistidine, desaminohomo-histidine, 
       desaminotyrosine and desaminophenylalanine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is glycine, alanine, serine, valine, D-alanine,
       aminoisobutyric acid, or N-methyl alanine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa at position 3 is glutamic acid, aspartic acid, glutamine or 
       asparagine

<400>  634

Xaa Xaa Xaa Gly 
1               


<210>  635
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is glycine, alanine, serine, valine, D-alanine,
       aminoisobutyric acid or N-methyl alanine

<400>  635

His Xaa Gln Gly 
1               


<210>  636
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is glycine, alanine, serine, valine, D-alanine,
       aminoisobutyric acid or N-methyl alanine

<400>  636

Phe Xaa Gln Gly 
1               


<210>  637
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine, hydroxy-histidine, 
       homo-histidine, tyrosine or phenylalanine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is glycine, alanine, serine, valine, D-alanine,
       aminoisobutyric acid or N-methyl alanine

<400>  637

Xaa Xaa Gln Gly 
1               


<210>  638
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is glycine, alanine, serine, valine, D-alanine,
       aminoisobutyric acid or N-methyl alanine

<400>  638

Tyr Xaa Gln Gly 
1               


<210>  639
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  639

His Ala Gln Gly 
1               


<210>  640
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  640

Phe Ala Gln Gly 
1               


<210>  641
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  641

Tyr Ala Gln Gly 
1               


<210>  642
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Hydroxyl group replacing the native N-terminal amine

<400>  642

His Ala Glu Gly 
1               


<210>  643
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  643

His Ala Glu Gly 
1               


<210>  644
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  644

Phe Ala Glu Gly 
1               


<210>  645
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide B (dF,dF)

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is D-Phe

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Phe linked to the phenyl lactic acid (PLA) at position 3
       via an ester bond

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is PLA

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is alpha isobutyric acid (AIB)

<220>
<221>  MOD_RES
<222>  (41)..(41)
<223>  C-terminus alpha carboxylate replaced with amide

<400>  645

Xaa Xaa Xaa Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 
1               5                   10                  15      


Glu Glu Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30          


Pro Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40      


<210>  646
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  HO-Phe7,Glu22,GLP-Ces

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is PLA

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is alpha isobutyric acid (AIB)

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminus alpha carboxylate replaced with amide

<400>  646

Xaa Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  647
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide B (dF,dV)

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is D-Phe

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Val linked to the phenyl lactic acid (PLA) at position 3
       via an ester bond

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is PLA

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is alpha isobutyric acid (AIB)

<220>
<221>  MOD_RES
<222>  (41)..(41)
<223>  C-terminus alpha carboxylate replaced with amide

<400>  647

Xaa Xaa Xaa Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 
1               5                   10                  15      


Glu Glu Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30          


Pro Ser Ser Gly Ala Pro Pro Pro Ser 
        35                  40      


<210>  648
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Ser11, Glu22 GLP-Cex

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminus alpha carboxylate replaced with amide

<400>  648

His Xaa Glu Gly Ser Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  649
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide D Ser11(dF,dV)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Ser is linked to D-Phe-D-Val via an ester bond formed through the
       carboxyl group of D-Val and the hydroxyl group of Ser side chain.

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminus alpha carboxylate replaced with amide

<400>  649

His Xaa Glu Gly Ser Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  650
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  desNH2-His7, Ser8, Glu22 GLP-Cex

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is desamino-His

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminus alpha carboxylate replaced with amide

<400>  650

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  651
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide F- Ser2(dF,dV)

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is desamino-His

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser is linked to D-Phe-D-Val via an ester bond formed through the
       carboxyl group of D-Val and the hydroxyl group of Ser side chain.

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminus alpha carboxylate replaced with amide

<400>  651

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  652
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide X-Ser2(dF,dV)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser is linked to D-Phe-D-Val via an ester bond formed through the
       carboxyl group of D-Val and the hydroxyl group of Ser side chain

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminus alpha carboxylate replaced with amide

<400>  652

His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  653
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<223>  Aib8, Glu22 GLP-Cex 40kPeg

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys is covalently attached to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminus alpha carboxylate replaced with amide

<400>  653

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly Arg Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  654
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<223>  GLP Aib8, Ser11 (dF, dV) Glu22 GLP-Cex 40kPeg

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Ser is linked to D-Phe-D-Val via ester bond formed through the 
       carboxyl group of d-Val and the hydroxyl group of the Ser side 
       chain

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys is covalently attached to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminus alpha carboxylate replaced with amide

<400>  654

His Xaa Glu Gly Ser Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly Arg Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  655
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<223>  GLP des-NH2His7, Ser8, Glu22-Cex 40kPeg

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is desamino-His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys is covalently attached to a 40kDa PEG

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminus alpha carboxylate replaced with amide

<400>  655

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly Arg Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  656
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<223>  GLP des-NH2His7, Ser8(dFdV), Glu22-Cex 40kPeg

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is desamino-His

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser is linked to D-Phe-D-Val via an ester bond formed through the
       carboxyl group of d-Val and the hydroxyl group of the Ser side 
       chain

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys is covalently attached to a 40kDa PEG

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  C-terminus alpha carboxylate replaced with amide

<400>  656

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly Arg Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  

<210>  657
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<223>  GHRH

<400>  657

Tyr Ala Asp Ala Ile Phe Thr Asn Ser Tyr Arg Lys Val Leu Gly Gln 
1               5                   10                  15      


Leu Ser Ala Arg Lys Leu Leu Gln Asp Ile Met Ser Arg Gln Gln Gly 
            20                  25                  30          


<210>  658
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<223>  VIP

<400>  658

His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  659
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<223>  PACAP-27

<400>  659

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  660
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<223>  PHM

<400>  660

His Ala Asp Gly Val Phe Thr Ser Asp Phe Ser Arg Leu Leu Gly Gln 
1               5                   10                  15      


Leu Ser Ala Lys Lys Tyr Leu Glu Ser Leu Met 
            20                  25          


<210>  661
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<223>  Secretin

<400>  661

His Ser Asp Gly Thr Phe Thr Ser Glu Leu Ser Arg Leu Arg Glu Gly 
1               5                   10                  15      


Ala Arg Leu Gln Arg Leu Leu Gln Gly Leu Val 
            20                  25          


<210>  662
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<223>  exendin-4

<400>  662

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  663
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon-like peptide-2 (GLP-2)

<400>  663

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  664
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<223>  GIP

<400>  664

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  665
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<223>  Oxyntomodulin

<400>  665

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  666
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  666

Lys Gly Lys Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
1               5                   10              


<210>  667
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MISC_FEATURE
<223>  GLP-1 full legnth native sequence

<400>  667

His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 
1               5                   10                  15      


Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu 
            20                  25                  30          


Val Lys Gly Arg Gly 
        35          


<210>  668

<400>  668
000

<210>  669

<400>  669
000

<210>  670

<400>  670
000

<210>  671

<400>  671
000

<210>  672

<400>  672
000

<210>  673

<400>  673
000

<210>  674

<400>  674
000

<210>  675

<400>  675
000

<210>  676

<400>  676
000

<210>  677

<400>  677
000

<210>  678

<400>  678
000

<210>  679

<400>  679
000

<210>  680

<400>  680
000

<210>  681

<400>  681
000

<210>  682

<400>  682
000

<210>  683

<400>  683
000

<210>  684

<400>  684
000

<210>  685

<400>  685
000

<210>  686

<400>  686
000

<210>  687

<400>  687
000

<210>  688

<400>  688
000

<210>  689

<400>  689
000

<210>  690

<400>  690
000

<210>  691

<400>  691
000

<210>  692

<400>  692
000

<210>  693

<400>  693
000

<210>  694

<400>  694
000

<210>  695

<400>  695
000

<210>  696

<400>  696
000

<210>  697

<400>  697
000

<210>  698

<400>  698
000

<210>  699

<400>  699
000

<210>  700

<400>  700
000

<210>  701
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  701

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  702
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Ser, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  702

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  703
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Arg, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  703

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Xaa Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  704
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Asp, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  704

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  705
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Gln, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  705

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  706
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Gln, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  706

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Xaa Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  707
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Lys, Arg, His, Asp, Glu, cysteic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Thr, Lys, Arg, His, Asp, Glu, cysteic acid or homocysteic 
       acid

<400>  707

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  708
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Thr, Asp or Glu

<400>  708

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  709
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Asp or Glu

<400>  709

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Xaa 
            20                  25                  


<210>  710
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  710

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  711
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  711

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  712
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Lys, Arg or His

<400>  712

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Xaa 
            20                  25                  


<210>  713
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  713

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  714
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  pegylation

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  714

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  715
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  pegylation

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  715

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  716
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  pegylation

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 = Met, Leu or Nle

<400>  716

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  717
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  pegylation

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 = Met, Leu or Nle

<400>  717

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  718
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  pegylation

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  718

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Lys Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  719
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  pegylation

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  719

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Lys Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  720
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4

<400>  720

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  721
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment representing the carboxy terminal 8 amino acids 
       of oxyntomodulin

<400>  721

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  722
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment representing the amino 4 amino acids of 
       oxyntomodulin carboxy terminus of SEQ ID NO: 21

<400>  722

Lys Arg Asn Arg 
1               


<210>  723
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  723

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  724
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  724

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  725
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  725

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  726
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  726

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Arg Asn 
            20                  25                  30          


Arg 
    


<210>  727
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  727

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  728
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon Analogue

<400>  728

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  729
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  2-butyrolactone bound through thiol group of cys

<400>  729

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  730
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  carboxymethyl group bound through thiol group of cys

<400>  730

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  731
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  731

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  732
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Asp, Glu, Lys, Arg or His

<400>  732

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Xaa 
            20                  25                  30  


<210>  733
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Asn, Lys, Arg, His, Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Thr, Lys, Arg, His, Asp or Glu

<400>  733

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  734
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Thr or an acidic amino acid

<400>  734

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  735
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  735

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Glu Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  736
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  736

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Glu Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  737
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  737

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Glu Thr Lys Arg Asn 
            20                  25                  30          


Arg 
    


<210>  738
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  738

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Glu Thr 
            20                  25                  


<210>  739
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa can be any amino acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa can be any amino acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met comprises Z

<400>  739

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met 
            20                  25          


<210>  740
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is alpha, alpha-dimethyl imidiazole acetic acid (DMIA)

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEG group attached to cysteine at residue 24

<400>  740

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  741
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa us DMIA

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Glutamine to alanine mutation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  PEG group attached to cysteine at residue 29

<400>  741

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Ala Trp Leu Met Asn Cys 
            20                  25                  


<210>  742
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is DMIA

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEG group attached to cysteine at residue 24

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa can be either norleucine or leucine

<400>  742

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  743
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is DMIA

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Glutamine to alanine mutation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa can be either norleucine or leucine

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  PEG group attached to cysteine at residue 29

<400>  743

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Ala Trp Leu Xaa Asn Cys 
            20                  25                  


<210>  744
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 701 with A20,A24,Nle27,D28

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Nle

<400>  744

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  745
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 701 with A20,A24,Nle27,D28,E29

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Nle

<400>  745

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  746
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 701 with A20,A24,Nle27,D28,E30

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Nle

<400>  746

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Asp Thr Glu 
            20                  25                  30  


<210>  747
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 701 with A20,A24,Nle27,E28,E29

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Nle

<400>  747

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Glu Glu 
            20                  25                  


<210>  748
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 701 with A20,A24,Nle27,E28,E30

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Nle

<400>  748

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Glu Thr Glu 
            20                  25                  30  


<210>  749
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 701 with A20,A24,Nle27,E29,E30

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Nle

<400>  749

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Asn Glu Glu 
            20                  25                  30  


<210>  750
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 701 with A20,E21,A24,Nle27,D28

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Nle

<400>  750

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  751
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 701 with A20,E21,A24,Nle27,D28,E29

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Nle

<400>  751

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  752
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 701 with A20,E21,A24,Nle27,D28,E30

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Nle

<400>  752

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  753
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO :701 with A20,E21,A24,Nle27,E28,E29

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Nle

<400>  753

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Glu Glu 
            20                  25                  


<210>  754
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 701 with A20, E21, A24, Nle27, E28, E30

<400>  754

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  755
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 701 with A20, E21, A24, Nle27, E29, E30

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Nle

<400>  755

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asn Glu Glu 
            20                  25                  30  


<210>  756
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with T16, A20, E21, A24, Nle27, D28, and E29

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Nle

<400>  756

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  757
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  757

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  758
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  758

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  759

<400>  759
000

<210>  760

<400>  760
000

<210>  761

<400>  761
000

<210>  762

<400>  762
000

<210>  763

<400>  763
000

<210>  764

<400>  764
000

<210>  765

<400>  765
000

<210>  766

<400>  766
000

<210>  767

<400>  767
000

<210>  768

<400>  768
000

<210>  769

<400>  769
000

<210>  770

<400>  770
000

<210>  771

<400>  771
000

<210>  772

<400>  772
000

<210>  773

<400>  773
000

<210>  774

<400>  774
000

<210>  775

<400>  775
000

<210>  776

<400>  776
000

<210>  777

<400>  777
000

<210>  778

<400>  778
000

<210>  779

<400>  779
000

<210>  780

<400>  780
000

<210>  781

<400>  781
000

<210>  782

<400>  782
000

<210>  783

<400>  783
000

<210>  784

<400>  784
000

<210>  785

<400>  785
000

<210>  786

<400>  786
000

<210>  787

<400>  787
000

<210>  788

<400>  788
000

<210>  789

<400>  789
000

<210>  790

<400>  790
000

<210>  791

<400>  791
000

<210>  792

<400>  792
000

<210>  793

<400>  793
000

<210>  794

<400>  794
000

<210>  795

<400>  795
000

<210>  796

<400>  796
000

<210>  797

<400>  797
000

<210>  798

<400>  798
000

<210>  799

<400>  799
000

<210>  800

<400>  800
000

<210>  801
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  wild type glucagon

<400>  801

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  802
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(31)
<223>  GLP-1(7-37)

<400>  802

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  803
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(30)
<223>  GLP-1(7-36) amidated

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  803

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  804
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  mat_peptide
<222>  (1)..(42)
<223>  gastric inhibitory polypeptide

<400>  804

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  805
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 61


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20.

<400>  805

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  806
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 62


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20.

<400>  806

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  807
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 63


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam bridge between residues 12 and 16.

<400>  807

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  808
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 66

<400>  808

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Ile Ala Trp Leu Leu Ala Gln 
            20                  25                  


<210>  809
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 68

<400>  809

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Ile His Gln Glu Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  810
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 69


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  810

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Ile His Gln Glu Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  811
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 84


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  811

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Ile Cys Trp Leu Leu Ala Gln 
            20                  25                  


<210>  812
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 85


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG group (20k) attached to cysteine at residue 24

<400>  812

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Ile Cys Trp Leu Leu Ala Gln 
            20                  25                  


<210>  813
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 92

<400>  813

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Lys His Gln Lys Glu Phe Ile Ala Trp Leu Leu Ala Gln 
            20                  25                  


<210>  814
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 93


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Lactam bridge between residues 17 and 21

<400>  814

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Lys His Gln Lys Glu Phe Ile Ala Trp Leu Leu Ala Gln 
            20                  25                  


<210>  815
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 95


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  815

His Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  816
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 96


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  816

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  817
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 97


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  817

His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  818
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 98


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  818

Tyr Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  819
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 99

<400>  819

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln 
        35                  40          


<210>  820
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 100


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<400>  820

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln 
        35                  40          


<210>  821
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 101

<400>  821

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln 
        35                  40          


<210>  822
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 102


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<400>  822

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Cys Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln 
        35                  40          


<210>  823
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 104

<400>  823

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Cys Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln 
        35                  40          


<210>  824
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 105


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40k) attached to cysteine and residue 24

<400>  824

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Cys Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln 
        35                  40          


<210>  825
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 106

<400>  825

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  826
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 107


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  826

His Ser Gln Gly Thr Phe Ile Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  827
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 108


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  827

His Ser Gln Gly Thr Phe Ile Ser Asp Tyr Ser Lys Ala Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  828
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide Analog 109


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  828

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  829
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 110


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  829

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  830
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 111


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  830

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  831
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 113


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is 3-phenyllactic acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge between residues 11 and 15

<400>  831

Xaa Ile Ser Asp Tyr Ser Ile Ala Met Asp Glu Ile His Gln Lys Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln 
            20                  


<210>  832
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 114


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is 3-phenyllactic acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge between residues 11 and 15

<400>  832

Xaa Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Ile His Gln Lys Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln 
            20                  


<210>  833
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 115


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  833

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  834
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 116


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  834

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  835
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 118


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  835

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  836
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 120


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  836

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  837
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 124


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  837

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  838
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 125


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  838

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  839
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 127


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  839

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  840
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 128


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  840

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  841
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 129


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  841

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  842
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 139


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  842

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  843
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 140


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  843

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  844
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 141


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residuess 16 and 20

<400>  844

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Met Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  845
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 142


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  845

Tyr Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  846
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 143


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  846

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  847
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 144


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  847

Tyr Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  848
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 145


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  848

Tyr Ala Gln Gly Thr Phe Ile Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  849
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 146


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  849

Tyr Ala Gln Gly Thr Phe Ile Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  850
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 147


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  850

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  851
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 148


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  851

Tyr Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  852
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 149


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  852

Tyr Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  853
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 150


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  853

Tyr Ser Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  854
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 151


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  854

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  855
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 152


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  855

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  856
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 154


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is hippuric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  856

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  857
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 155


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam bridge between residues 12 and 16

<400>  857

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  858
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 156


<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam bridge between residues 20 and 24

<400>  858

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Glu Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  859
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 157


<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam bridge between residues 24 and 28

<400>  859

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Glu Trp Leu Leu Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  860
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 158


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  860

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  861
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 162


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  861

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Tyr Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Val Lys Glu Phe Val Asn Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  862
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 163


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  862

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly 
            20                  25                  


<210>  863
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 164


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  863

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly 
            20                  25                  


<210>  864
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 165


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  864

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  865
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 166


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-alanine

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  865

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  866
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 167


<220>
<221>  MISC_FEATURE
<222>  (17)..(20)
<223>  Lactam bridge between residues 17 and 20

<400>  866

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  867
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 168


<220>
<221>  MISC_FEATURE
<222>  (18)..(21)
<223>  Lactam bridge between residues 18 and 21

<400>  867

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Lys Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  868
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 169


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  868

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly 
            20                  25                  


<210>  869
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 170


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  PEG (40k) attached to cysteine at residue 40

<400>  869

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  870
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 172


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40k) attached to cysteine at residue 24

<400>  870

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly 
            20                  25                  


<210>  871
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 174


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  871

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  872
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 175


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40k) attached to cysteine at residue 24

<400>  872

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  873
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 176


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  873

Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  874
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 177


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  874

Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly 
            20                  25                  


<210>  875
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 178


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  PEG (40k) attached to cysteine at residue 40

<400>  875

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  876
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 179


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40k) attached to cysteine at residue 24

<400>  876

Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly 
            20                  25                  


<210>  877
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 182


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  PEG (40k) attached to cysteine at residue 40

<400>  877

Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  878
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 186


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40k) attached to cysteine at residue 24

<400>  878

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Met Asn Gly 
            20                  25                  


<210>  879
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 191


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<400>  879

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  880
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 192

<400>  880

Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu Gln Ala Ala Lys Glu 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  881
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 194


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Aib

<400>  881

Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu Glu 
1               5                   10                  15      


Ala Val Arg Leu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser 
            20                  25                  30          


Gly Ala Pro Pro Pro Ser 
        35              


<210>  882
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 197


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  Lactam bridge between residues 13 and 17

<400>  882

Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu Gln Ala Ala 
1               5                   10                  15      


Lys Glu Phe Val Asn Trp Leu Leu Ala Gly 
            20                  25      


<210>  883
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 198


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge between residues 15 and 19

<400>  883

Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu Gln 
1               5                   10                  15      


Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly 
            20                  25              


<210>  884
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 199


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  884

Tyr Xaa Gln Gly Thr Phe Val Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  885
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 200


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  885

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  886
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 201


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<400>  886

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  887
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 202


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  PEG (40k) attached to cysteine at residue 40

<400>  887

Tyr Xaa Gln Gly Thr Phe Val Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  888
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 203


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  PEG (40k) attached to cysteine at residue 40

<400>  888

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  889
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 204


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  889

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Arg Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  890
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 205


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  PEG (40k) attached to cysteine at residue 40

<400>  890

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Arg Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  891
<211>  43
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 206


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  891

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  892
<211>  43
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 207


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  892

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  893
<211>  43
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 208


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  PEG (40k) attached to cysteine at residue 43

<400>  893

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  894
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide Analog 209


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (9)..(12)
<223>  Lactam bridge between residues 9 and 12

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  894

Tyr Xaa Gln Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  895
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide CEX

<400>  895

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  896
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<400>  896

Xaa Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10      


<210>  897
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  897

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  898
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  898

Lys Arg Asn Arg 
1               


<210>  899

<400>  899
000

<210>  900

<400>  900
000

<210>  901
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  901

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  902
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<400>  902

Ser Gln Gly Thr Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg 
1               5                   10                  15      


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25              


<210>  903
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<400>  903

Gln Gly Thr Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg 
1               5                   10                  15      


Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25          


<210>  904
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<400>  904

Gly Thr Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala 
1               5                   10                  15      


Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25      


<210>  905
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<400>  905

Thr Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln 
1               5                   10                  15      


Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25  


<210>  906
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is glutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is Met, Leu or Nle

<400>  906

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  907
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  907

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  908
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  908

Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  909
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  909

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  910
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  910

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Xaa 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  911
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypetide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  911

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  


<210>  912
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  912

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  


<210>  913
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  913

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Cys Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  914
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  914

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Xaa Asn Thr 
            20                  


<210>  915
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  915

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Cys 
            20                  


<210>  916
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  916

Phe Thr Ser Xaa Tyr Ser Arg Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Lys Trp Leu Xaa Asn Thr 
            20                  


<210>  917
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  917

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Cys Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Xaa Asn Thr 
            20                  


<210>  918
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  918

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Glu Cys Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  919
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4

<400>  919

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  920
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 8 amino acids 
       of oxyntomodulin

<400>  920

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  921
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy 4 amino acids of 
       oxyntomodulin carboxy terminus

<400>  921

Lys Arg Asn Arg 
1               


<210>  922
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Lys, Cys, Orn, homocycstein or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocycstein or acetyl phenyalanine

<400>  922

Phe Thr Ser Arg Tyr Ser Xaa Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Met Asn Thr 
            20                  


<210>  923
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  923

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Xaa 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  924
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  924

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr Lys Arg Asn Arg Asn Asn Ile Ala 
            20                  25                  30          


<210>  925
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  925

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  926
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Pegylation

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  926

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Xaa 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn Arg Asn Asn Ile Ala 
            20                  25                  30          


<210>  927
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  927

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Xaa 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn Arg 
            20                  25              


<210>  928
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  928

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr Lys Arg Asn Arg 
            20                  25              


<210>  929
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  929

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  930
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  930

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn Arg Asn Asn Ile Ala 
            20                  25                  30          


<210>  931
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  931

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Cys 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn Arg 
            20                  25              


<210>  932
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  932

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  933
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  933

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  934
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  2-butyrolactone bound through thiol group of Cysteine

<400>  934

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  935
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analogue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Carboxymethyl group bound through thiol group of Cysteine

<400>  935

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  936
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  936

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Glu Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  937
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  937

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  938
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  938

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  939
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Asp, Glu, cysteic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa id Thr, Asp, Glu, cysteic acid or homocysteic acid

<400>  939

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  940
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Glu, cysteic acid, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  940

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  941
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Glu, cysteic acid, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr, glu or Asp

<400>  941

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  942
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Glu, cysteic acid, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  942

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  943
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  20kDa PEG group attached to Xaa at position 11

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  943

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Cys Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  944
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  20kDa PEG group attached to Xaa at position 16

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  944

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Cys 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  945
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  945

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Xaa Xaa Xaa 
            20                  


<210>  946
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Lys, Cys, Orn, homocycstein or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Pegylated

<400>  946

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa Xaa Gly Pro Ser Ser Gly Ala Pro 
            20                  25                  30          


Pro Pro Ser 
        35  


<210>  947
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Pegylated

<400>  947

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Xaa 
        35  


<210>  948
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  948

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  949
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met , Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Pegylated

<400>  949

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Xaa 
        35  


<210>  950
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<400>  950

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  951
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  951

Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp 
1               5                   10                  15      


Leu Met Asn Thr 
            20  


<210>  952
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Homocysteic acid

<400>  952

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  953
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<400>  953

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Xaa 
1               5                   10      


<210>  954
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenyl lactic acid

<400>  954

His Ser Gln Gly Thr Xaa 
1               5       


<210>  955
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<400>  955

Ser Gln Gly Thr Xaa 
1               5   


<210>  956
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is phenyl lactic acid

<400>  956

Gln Gly Thr Xaa 
1               


<210>  957
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is phenyl lactic acid

<400>  957

Gly Thr Xaa 
1           


<210>  958
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is phenyl lactic acid

<400>  958

Thr Xaa 
1       


<210>  959
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of His, D-histidine, 
       alpha, alpha-dimethyl imidiazole acetic acid (DMIA), N-methyl 
       histidine, alpha-methyl histidine, imidazole acetic acid, 
       desaminohistidine, hydroxyl-histidine, acetyl-histidine and 
       

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, Val, Gly, N-methyl serine, N-methyl alanine, and 
       aminoisobutyric acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is selected from a group consisting of Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenyl lactic acid

<400>  959

Xaa Xaa Xaa Gly Thr Xaa 
1               5       


<210>  960
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, Val, Gly, N-methyl serine, N-methyl alanine, and 
       aminoisobutyric acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<400>  960

Xaa Xaa Gly Thr Xaa 
1               5   


<210>  961
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Glu and Gln

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is phenyl lactic acid

<400>  961

Xaa Gly Thr Xaa 
1               


<210>  962
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AL

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate optionally replaced with amide

<400>  962

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  963
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AM

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate optionally replaced with amide

<400>  963

Ser Gln Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg 
1               5                   10                  15      


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25              


<210>  964
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AN

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Threonine in position 4 and phenyl lactic acid in position 5 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Optional C-terminal alpha carboxylate replaced with amide

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate optionally replaced with amide

<400>  964

Ser Gln Gly Thr Xaa Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg 
1               5                   10                  15      


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25              


<210>  965
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AO

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Threonine in position 5 and phenyl lactic acid in position 6 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal alpha carboxylate optionally replaced with amide

<400>  965

His Ser Gln Gly Thr Xaa Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  966
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AQ

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is amino isobutyric acid

<400>  966

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  967
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AT

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<400>  967

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  968
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of His, D-histidine, 
       alpha, alpha-dimethyl imidiazole acetic acid (DMIA), N-methyl 
       histidine, alpha-methyl histidine, imidazole acetic acid, 
       desaminohistidine, hydroxyl-histidine, acetyl-histidine and 
       

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, Val, Gly, N-methyl serine, N-methyl alanine, and 
       aminoisobutyric acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is selected from a group consisting of Glu or Gln

<400>  968

Xaa Xaa Xaa Thr Gly Phe 
1               5       


<210>  969
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, Val, Gly, N-methyl serine, N-methyl alanine, and 
       aminoisobutyric acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Glu or Gln

<400>  969

Xaa Xaa Thr Gly Phe 
1               5   


<210>  970
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Glu or Gln

<400>  970

Xaa Thr Gly Phe 
1               


<210>  971
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate optionally replaced with an amide

<400>  971

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  972

<400>  972
000

<210>  973

<400>  973
000

<210>  974

<400>  974
000

<210>  975

<400>  975
000

<210>  976

<400>  976
000

<210>  977

<400>  977
000

<210>  978

<400>  978
000

<210>  979

<400>  979
000

<210>  980

<400>  980
000

<210>  981

<400>  981
000

<210>  982

<400>  982
000

<210>  983

<400>  983
000

<210>  984

<400>  984
000

<210>  985

<400>  985
000

<210>  986

<400>  986
000

<210>  987

<400>  987
000

<210>  988

<400>  988
000

<210>  989

<400>  989
000

<210>  990

<400>  990
000

<210>  991

<400>  991
000

<210>  992

<400>  992
000

<210>  993

<400>  993
000

<210>  994

<400>  994
000

<210>  995

<400>  995
000

<210>  996

<400>  996
000

<210>  997

<400>  997
000

<210>  998

<400>  998
000

<210>  999

<400>  999
000

<210>  1000

<400>  1000
000

<210>  1001
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  1001

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  1002
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<400>  1002

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1003
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  1003

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  1004
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  1004

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  1005
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<400>  1005

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1006
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<400>  1006

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1007
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ser or Glu

<400>  1007

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Glu Trp Leu Met Asn Thr 
            20                  


<210>  1008
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ser or Glu

<400>  1008

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Glu Trp Leu Met Lys Thr 
            20                  


<210>  1009
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, homoglutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ala, Ser, Glu, Lys, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Gln, Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Ala, Gln, Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Lys or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  1009

Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Xaa Xaa Arg Arg Ala Xaa Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  


<210>  1010
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ala, Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Gln or Lys

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Ala, Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Lys or an acidic amino acid

<400>  1010

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Xaa Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Met Xaa Thr 
            20                  


<210>  1011
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ala, Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Gln or Lys

<400>  1011

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Xaa Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1012
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Lys or Gln

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1012

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Glu Arg Arg Ala Xaa Xaa 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  


<210>  1013
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Lys or Gln

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1013

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Xaa Xaa 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1014
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Lys or Gln

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1014

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Xaa Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  


<210>  1015
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid, homoglutamic 
       acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ala, Ser, Glu, Lys Gln, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Arg, Gln, Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Ala, Gln, Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Lys or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  1015

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Xaa Xaa Arg Arg Ala Xaa Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Xaa Xaa 
            20                  


<210>  1016
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Asp or Glu

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1016

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Thr 
            20                  


<210>  1017
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Asp or Glu

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1017

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Thr 
            20                  


<210>  1018
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ser or Glu

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Asp or Glu

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1018

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Glu Trp Leu Xaa Xaa Thr 
            20                  


<210>  1019
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ser or Glu

<220>
<221>  MISC_FEATURE
<222>  (19)..(23)
<223>  Lactam bridge connecting residues 19 and 23

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or Glu

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1019

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Glu Trp Leu Xaa Lys Xaa 
            20                  


<210>  1020
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ala, Ser, Glu, Lys Gln, homoglutamic acid or homocysteine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Arg, Gln, Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Ala, Gln, Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Lys, Asp, Glu, cysteic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr, Asp, Glu, cysteic acid and homocysteic acid

<400>  1020

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Xaa Xaa Arg Arg Ala Xaa Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Xaa Xaa 
            20                  


<210>  1021
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4

<400>  1021

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  1022
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid and homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1022

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1023
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid and homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1023

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1024
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid and homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1024

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Glu Trp Leu Xaa Asn Thr 
            20                  


<210>  1025
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid and homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(24)
<223>  Lactam bridge connecting residues 19 and 24

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1025

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Glu Trp Leu Xaa Lys Thr 
            20                  


<210>  1026
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 8 amino acids 
       of oxyntomodulin

<400>  1026

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  1027
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy 4 amino acids of 
       oxyntomodulin carboxy terminus

<400>  1027

Lys Arg Asn Arg 
1               


<210>  1028
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  1028

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1029
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<400>  1029

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1030
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<400>  1030

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1031
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<400>  1031

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1032
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<400>  1032

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1033
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<400>  1033

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1034
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<400>  1034

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1035
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<400>  1035

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1036
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<400>  1036

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1037
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  1037

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ala Arg Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Arg Glu Phe Ile Lys Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  1038
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1038

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1039
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1039

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1040
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  1040

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  1041
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analogue

<400>  1041

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1042
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  2-butyrolactone bound through thiol group of Cysteine

<400>  1042

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  1043
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analogue

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Carboxymethyl group bound through thiol group of Cysteine

<400>  1043

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  1044
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  1044

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Arg Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1045
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Lys, Asp, Glu, cysteic acid and homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr, Asp, Glu, cysteic acid and homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Pegylated

<400>  1045

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa Xaa Gly Pro Ser Ser Gly Ala Pro 
            20                  25                  30          


Pro Pro Ser 
        35  


<210>  1046
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Lys, Asp, Glu, cysteic acid and homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr, Asp, Glu, cysteic acid and homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa is Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Pegylated

<400>  1046

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Xaa 
        35  


<210>  1047
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is glutamic acid, homoglutamic acid, cysteic acid or 
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Asp or Glu

<400>  1047

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Thr 
            20                  


<210>  1048
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is glutamic acid, homoglutamic acid,  cysteic acid or 
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Asp or Glu

<400>  1048

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Thr 
            20                  


<210>  1049
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  1049

Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp Phe 
1               5                   10                  15      


Val Gln Trp Leu Met Asp Thr 
            20              


<210>  1050
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4 plus one additional amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is selected form the group consisting of Cys, Orn, Lys, 
       homocysteine and acetyl phenyalanine

<400>  1050

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Xaa 
1               5                   10      


<210>  1051
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid, homoglutamic 
       acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ala, Ser, Glu, Lys Gln, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Arg, Gln, Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Ala, Gln, Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Lys or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr, Gly or an acidic amino acid

<400>  1051

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Xaa Xaa Arg Arg Ala Xaa Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Xaa Xaa 
            20                  


<210>  1052
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenyl lactic acid

<400>  1052

His Ser Gln Gly Thr Xaa 
1               5       


<210>  1053
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<400>  1053

Ser Gln Gly Thr Xaa 
1               5   


<210>  1054
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is phenyl lactic acid

<400>  1054

Gln Gly Thr Xaa 
1               


<210>  1055
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is phenyl lactic acid

<400>  1055

Gly Thr Xaa 
1           


<210>  1056
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is phenyl lactic acid

<400>  1056

Thr Xaa 
1       


<210>  1057
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of His, D-histidine, 
       alpha, alpha-dimethyl imidiazole acetic acid (DMIA), N-methyl 
       histidine, alpha-methyl histidine, imidazole acetic acid, 
       desaminohistidine, hydroxyl-histidine, acetyl-histidine and 
       

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, Val, Gly, N-methyl serine, N-methyl alanine, and 
       aminoisobutyric acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is selected from a group consisting of Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenyl lactic acid

<400>  1057

Xaa Xaa Xaa Gly Thr Xaa 
1               5       


<210>  1058
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, Val, Gly, N-methyl serine, N-methyl alanine, and 
       aminoisobutyric acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<400>  1058

Xaa Xaa Gly Thr Xaa 
1               5   


<210>  1059
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is phenyl lactic acid

<400>  1059

Xaa Gly Thr Xaa 
1               


<210>  1060
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide A

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1060

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1061
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide B

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1061

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1062
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide C

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(7)
<223>  Lactam bridge connecting residues 4 and 7

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1062

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1063
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide D

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1063

Ala Glu Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg 
1               5                   10                  15      


Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25              


<210>  1064
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide E

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Threonine in position 4 and phenyl lactic acid in position 5 are 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1064

Ala Glu Gly Thr Xaa Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg 
1               5                   10                  15      


Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25              


<210>  1065
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide F

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1065

Ser Gln Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg 
1               5                   10                  15      


Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25              


<210>  1066
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide G

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Threonine in position 4 and phenyl lactic acid in position 5 are 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1066

Ser Gln Gly Thr Xaa Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg 
1               5                   10                  15      


Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25              


<210>  1067
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide H

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Covalently linked to a cholesterol acid moiety

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 to 15

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1067

Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1068
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide I

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Covalently linked to a cholesterol acid moiety

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1068

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr Lys 
            20                  25  


<210>  1069
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide J

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connectiong residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Covalently linked to a cholesterol acid moiety

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1069

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Lys 
        35  


<210>  1070
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide K

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is amino isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Threonine in position 4 and phenyl lactic acid in position 5 are 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connectiong residues 15 and 19

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1070

Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg 
1               5                   10                  15      


Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25              


<210>  1071
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide L

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1071

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1072
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide M

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1072

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1073
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide N

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1073

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1074
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide O

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  C-termincal alpha carboxylate replaced with amide

<400>  1074

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1075
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide P

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1075

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1076
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide Q

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1076

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1077
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide R

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1077

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Glu Trp Leu Met Asp Thr 
            20                  


<210>  1078
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide S

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (19)..(23)
<223>  Lactam bridge connecting residues 19 and 23

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1078

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Glu Trp Leu Met Lys Thr 
            20                  


<210>  1079
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide T

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1079

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Gln Ala Ala Lys Asp 
1               5                   10                  15      


Phe Ile Ala Trp Leu Met Asp Thr 
            20                  


<210>  1080
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide U

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1080

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Gln Ala Ala Lys Glu 
1               5                   10                  15      


Phe Ile Ala Trp Leu Met Asp Thr 
            20                  


<210>  1081
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide V

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1081

Ala Glu Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg 
1               5                   10                  15      


Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25              


<210>  1082
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide W

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1082

Ala Glu Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Gln 
1               5                   10                  15      


Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25              


<210>  1083
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide X

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge connection residues 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1083

His Ala Glu Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  1084
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide Y

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge connecting bridges 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1084

His Ala Glu Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  1085
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide Z

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  Lactam bridge connecting residues 13 and 17

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1085

Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala 
1               5                   10                  15      


Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25      


<210>  1086
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AA

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Threonine in position 5 and phenyl lactic acid in position 6 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1086

Ser Gln Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg 
1               5                   10                  15      


Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25              


<210>  1087
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AB

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Threonine at position 5 and phenyl lactic acid at position 6 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge connecting residues 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1087

His Ala Glu Gly Thr Xaa Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  1088
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AC

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1088

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Met Asp Thr 
            20                  


<210>  1089
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AD

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1089

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Cys 
        35  


<210>  1090
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AE

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1090

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Met Asp Thr 
            20                  


<210>  1091
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AF

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1091

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Cys 
        35  


<210>  1092
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AG

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Covalently attached to a C16 fatty acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connection residues 11 and 15

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1092

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1093
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AH

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Linked to a C16 fatty acid via Glu residue

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Linked to a C16 fatty acid via Glu residue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1093

Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1094
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AI

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Linked to C16 fatty acid via Glu residue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1094

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1095
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AJ

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Linked to a C16 fatty acid via Glu residue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1095

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Lys Trp Leu Met Asp Thr 
            20                  


<210>  1096
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AK

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Linked to a C16 fatty acid via Glu residue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1096

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Lys 
            20                  


<210>  1097
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AP

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is amino isobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1097

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1098
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AR

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is alpha isobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1098

Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Xaa Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Met Asn Thr 
            20                  


<210>  1099
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AS

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1099

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1100
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AU

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1100

Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Met Asn Thr 
            20                  


<210>  1101
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AV

<220>
<221>  MISC_FEATURE
<222>  (4)..(7)
<223>  Lactam bridge connecting residues 4 and 7

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is alpha isobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal carboxylate replaced with amide

<400>  1101

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1102
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AW

<220>
<221>  MISC_FEATURE
<222>  (4)..(7)
<223>  Lactam bridge connecting residues 4 and 7

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is alpha isobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal carboxylate replaced with amide

<400>  1102

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1103
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AX

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1103

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Glu 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1104
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AY

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1104

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Gln Ala Ala Lys Glu 
1               5                   10                  15      


Phe Ile Ala Trp Leu Met Asn Thr 
            20                  


<210>  1105
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AZ

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1105

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1106
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide BA

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Linked to a C16 fatty acid via Glu residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Linked to a C16 fatty acid via Glu residue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal carboxylate replaced with amide

<400>  1106

Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1107
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa1 is selected from a group consisting of His, D-histidine, 
       alpha, alpha-dimethyl imidiazole acetic acid (DMIA), N-methyl 
       histidine, alpha-methyl histidine, imidazole acetic acid, 
       desaminohistidine, hydroxyl-histidine, acetyl-histidine and 
       

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, valine, glycine, N-methyl serine, and aminoisobutyric 
       acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is selected from a group consisting of Glu or Gln

<400>  1107

Xaa Xaa Xaa Thr Gly Phe 
1               5       


<210>  1108
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, valine, glycine, N-methyl serine, and aminoisobutyric 
       acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Glu or Gln

<400>  1108

Xaa Xaa Thr Gly Phe 
1               5   


<210>  1109
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Glu or Gln

<400>  1109

Xaa Thr Gly Phe 
1               


<210>  1110
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AL

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1110

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1111
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AM

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1111

Ser Gln Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg 
1               5                   10                  15      


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25              


<210>  1112
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AN

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Threonine at position 4 and phenyl lactic acid at position 5 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1112

Ser Gln Gly Thr Xaa Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg 
1               5                   10                  15      


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25              


<210>  1113
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AO

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Threorine at position 5 and phenyl lactic acid at position 6 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1113

His Ser Gln Gly Thr Xaa Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  1114
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1114

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Met Asn Thr 
            20                  


<210>  1115
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Pegylated via spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1115

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Lys Trp Leu Met Asp Thr 
            20                  


<210>  1116
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated via rigid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1116

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Lys Trp Leu Met Asp Thr 
            20                  


<210>  1117
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1117

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr Gly Pro Gly Pro Gly Pro Gly Pro 
            20                  25                  30          


Gly Pro Cys 
        35  


<210>  1118
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  C-terminal alpha carboxylate reaplaced with amide

<400>  1118

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Gly Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Cys 
        35  


