  
                                  SEQUENCE LISTING
  
  <110> Miles, Lindsey A.
        Yates III, John
        Chen, Emily
        Baik, Nagyung
        Parmer, Robert J.
  
  <120> NOVEL PLASMINOGEN RECEPTOR, POLYPEPTIDES
    & ANTIBODIES THEREOF
    
  
  <130> SLW2985.001WO1
  
  <160> 48
  
  <170> FastSEQ for Windows Version 4.0
  
  <210> 1
  <211> 147
  <212> PRT
  <213> Mus musculus
  
  <400> 1
  Met Gly Phe Ile Phe Ser Lys Ser Met Asn Glu Asn Met Lys Asn Gln
   1               5                  10                  15      
  Gln Glu Phe Met Val Thr His Ala Arg Leu Gln Leu Glu Arg His Leu
              20                  25                  30          
  Thr Met Gln Asn Glu Met Arg Glu Arg Gln Met Ala Met Gln Ile Ala
          35                  40                  45              
  Trp Ser Arg Glu Phe Leu Lys Tyr Phe Gly Thr Phe Phe Gly Ile Ala
      50                  55                  60                  
  Thr Ile Ser Leu Ala Thr Gly Ala Leu Lys Arg Lys Lys Pro Ala Phe
  65                  70                  75                  80  
  Leu Val Pro Ile Val Pro Leu Ser Phe Ile Phe Thr Tyr Gln Tyr Asp
                  85                  90                  95      
  Leu Gly Tyr Gly Thr Leu Leu Gln Arg Met Lys Ser Glu Ala Glu Asp
              100                 105                 110         
  Ile Leu Glu Thr Glu Lys Thr Lys Leu Glu Leu Pro Lys Gly Leu Ile
          115                 120                 125             
  Thr Phe Glu Ser Leu Glu Lys Ala Arg Arg Glu Gln Ser Lys Leu Phe
      130                 135                 140                 
  Ser Asp Lys
  145         
  
  
  <210> 2
  <211> 43
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> a synthetic peptide
  
  <220> 
  <221> VARIANT        
  <222> 21, 34, 38
  <223> Xaa = Lys or Arg
  
  <400> 2
  Arg Met Lys Ser Glu Ala Glu Asp Ile Leu Glu Thr Glu Lys Thr Lys
   1               5                  10                  15      
  Leu Glu Leu Pro Xaa Gly Leu Ile Thr Phe Glu Ser Leu Glu Lys Ala
              20                  25                  30          
  Arg Xaa Glu Gln Ser Xaa Leu Phe Ser Asp Lys
          35                  40              
  
  
  
  <210> 3
  <211> 43
  <212> PRT
  <213> Mus musculus
  
  <400> 3
  Arg Met Lys Ser Glu Ala Glu Asp Ile Leu Glu Thr Glu Lys Thr Lys
   1               5                  10                  15      
  Leu Glu Leu Pro Lys Gly Leu Ile Thr Phe Glu Ser Leu Glu Lys Ala
              20                  25                  30          
  Arg Arg Glu Gln Ser Lys Leu Phe Ser Asp Lys
          35                  40              
  
  
  <210> 4
  <211> 41
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> a synthetic peptide
  
  <220> 
  <221> VARIANT        
  <222> 19, 32, 36
  <223> Xaa = Lys or Arg
  
  <400> 4
  Lys Ser Glu Ala Glu Asp Ile Leu Glu Thr Glu Lys Thr Lys Leu Glu
   1               5                  10                  15      
  Leu Pro Xaa Gly Leu Ile Thr Phe Glu Ser Leu Glu Lys Ala Arg Xaa
              20                  25                  30          
  Glu Gln Ser Xaa Leu Phe Ser Asp Lys
          35                  40      
  
  
  
  <210> 5
  <211> 41
  <212> PRT
  <213> Mus musculus
  
  <400> 5
  Lys Ser Glu Ala Glu Asp Ile Leu Glu Thr Glu Lys Thr Lys Leu Glu
   1               5                  10                  15      
  Leu Pro Lys Gly Leu Ile Thr Phe Glu Ser Leu Glu Lys Ala Arg Arg
              20                  25                  30          
  Glu Gln Ser Lys Leu Phe Ser Asp Lys
          35                  40      
  
  
  <210> 6
  <211> 30
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> a synthetic peptide
  
  <220> 
  <221> VARIANT        
  <222> 8, 21, 25
  <223> Xaa = Lys or Arg
  
  <400> 6
  Lys Thr Lys Leu Glu Leu Pro Xaa Gly Leu Ile Thr Phe Glu Ser Leu
   1               5                  10                  15      
  Glu Lys Ala Arg Xaa Glu Gln Ser Xaa Leu Phe Ser Asp Lys
              20                  25                  30  
  
  
  <210> 7
  <211> 30
  <212> PRT
  <213> Mus musculus
  
  <400> 7
  Lys Thr Lys Leu Glu Leu Pro Lys Gly Leu Ile Thr Phe Glu Ser Leu
   1               5                  10                  15      
  Glu Lys Ala Arg Arg Glu Gln Ser Lys Leu Phe Ser Asp Lys
              20                  25                  30  
  
  
  
  
  
  <210> 8
  <211> 28
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> a synthetic peptide
  
  <220> 
  <221> VARIANT        
  <222> 6, 19, 23
  <223> Xaa = Lys or Arg
  
  <400> 8
  Lys Leu Glu Leu Pro Xaa Gly Leu Ile Thr Phe Glu Ser Leu Glu Lys
   1               5                  10                  15      
  Ala Arg Xaa Glu Gln Ser Xaa Leu Phe Ser Asp Lys
              20                  25              
  
  
  <210> 9
  <211> 28
  <212> PRT
  <213> Mus musculus
  
  <400> 9
  Lys Leu Glu Leu Pro Lys Gly Leu Ile Thr Phe Glu Ser Leu Glu Lys
   1               5                  10                  15      
  Ala Arg Arg Glu Gln Ser Lys Leu Phe Ser Asp Lys
              20                  25              
  
  
  <210> 10
  <211> 23
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> a synthetic peptide
  
  <220> 
  <221> VARIANT        
  <222> 1, 14, 18
  <223> Xaa = Lys or Arg
  
  <400> 10
  Xaa Gly Leu Ile Thr Phe Glu Ser Leu Glu Lys Ala Arg Xaa Glu Gln
   1               5                  10                  15      
  Ser Xaa Leu Phe Ser Asp Lys
              20              
  
       
  
  <210> 11
  <211> 23
  <212> PRT
  <213> Mus musculus
  
  <400> 11
  Lys Gly Leu Ile Thr Phe Glu Ser Leu Glu Lys Ala Arg Arg Glu Gln
   1               5                  10                  15      
  Ser Lys Leu Phe Ser Asp Lys
              20              
  
  
  
  <210> 12
  <211> 13
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> a synthetic peptide
  
  <220> 
  <221> VARIANT        
  <222> 4, 8
  <223> Xaa = Lys or Arg
  
  <400> 12
  Lys Ala Arg Xaa Glu Gln Ser Xaa Leu Phe Ser Asp Lys
   1               5                  10              
  
  
  <210> 13
  <211> 13
  <212> PRT
  <213> Mus musculus
  
  <400> 13
  Lys Ala Arg Arg Glu Gln Ser Lys Leu Phe Ser Asp Lys
   1               5                  10              
  
  
  <210> 14
  <211> 11
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> a synthetic peptide
  
  <220> 
  <221> VARIANT        
  <222> 2, 6
  <223> Xaa = Lys or Arg
  
  <400> 14
  Arg Xaa Glu Gln Ser Xaa Leu Phe Ser Asp Lys
   1               5                  10      
  
  
  
  <210> 15
  <211> 11
  <212> PRT
  <213> Mus musculus
  
  <400> 15
  Arg Arg Glu Gln Ser Lys Leu Phe Ser Asp Lys
   1               5                  10      
  
  
  <210> 16
  <211> 10
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> a synthetic peptide
  
  <220> 
  <221> VARIANT        
  <222> 1, 5
  <223> Xaa = Lys or Arg
  
  <400> 16
  Xaa Glu Gln Ser Xaa Leu Phe Ser Asp Lys
   1               5                  10  
  
  
  <210> 17
  <211> 10
  <212> PRT
  <213> Mus musculus
  
  <400> 17
  Arg Glu Gln Ser Lys Leu Phe Ser Asp Lys
   1               5                  10  
  
  
  
  <210> 18
  <211> 6
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> a synthetic peptide
  
  <220> 
  <221> VARIANT        
  <222> 1
  <223> Xaa = Lys or Arg
  
  <400> 18
  Xaa Leu Phe Ser Asp Lys
   1               5      
  
  
  <210> 19
  <211> 6
  <212> PRT
  <213> Mus musculus
  
  <400> 19
  Lys Leu Phe Ser Asp Lys
   1               5      
  
  
  <210> 20
  <211> 5
  <212> PRT
  <213> Mus musculus
  
  <400> 20
  Leu Phe Ser Asp Lys
   1               5  
  
  
  
  <210> 21
  <211> 19
  <212> PRT
  <213> Mus musculus
  
  <400> 21
  Thr Phe Glu Ser Leu Glu Lys Ala Arg Arg Glu Gln Ser Lys Leu Phe
   1               5                  10                  15      
  Ser Asp Lys
              
  
  
  <210> 22
  <211> 21
  <212> PRT
  <213> Mus musculus
  
  <400> 22
  Gly Thr Leu Leu Gln Arg Met Lys Ser Glu Ala Glu Asp Ile Leu Glu
   1               5                  10                  15      
  Thr Glu Lys Thr Lys
              20      
  
  
  <210> 23
  <211> 23
  <212> PRT
  <213> Mus musculus
  
  <400> 23
  Thr Glu Lys Thr Lys Leu Glu Leu Pro Lys Gly Leu Ile Thr Phe Glu
   1               5                  10                  15      
  Ser Leu Glu Lys Ala Arg Arg
              20              
  
  
  <210> 24
  <211> 5
  <212> PRT
  <213> Mus musculus
  
  <400> 24
  Lys Arg Lys Lys Pro
   1               5  
  
  
  <210> 25
  <211> 20
  <212> PRT
  <213> Mus musculus
  
  <400> 25
  Met Gly Phe Ile Phe Ser Lys Ser Met Asn Glu Asn Met Lys Asn Gln
   1               5                  10                  15      
  Gln Glu Phe Met
              20  
  
  
  <210> 26
  <211> 21
  <212> PRT
  <213> Mus musculus
  
  <400> 26
  Asn Glu Asn Met Lys Asn Gln Gln Glu Phe Met Val Thr His Ala Arg
   1               5                  10                  15      
  Leu Gln Leu Glu Arg
              20      
  
  
  <210> 27
  <211> 21
  <212> PRT
  <213> Mus musculus
  
  <400> 27
  Met Val Thr His Ala Arg Leu Gln Leu Glu Arg His Leu Thr Met Gln
   1               5                  10                  15      
  Asn Glu Met Arg Glu
              20      
  
  
  
  
  <210> 28
  <211> 23
  <212> PRT
  <213> Mus musculus
  
  <400> 28
  Arg His Leu Thr Met Gln Asn Glu Met Arg Glu Arg Gln Met Ala Met
   1               5                  10                  15      
  Gln Ile Ala Trp Ser Arg Glu
              20              
  
  
  <210> 29
  <211> 23
  <212> PRT
  <213> Mus musculus
  
  <400> 29
  Glu Arg Gln Met Ala Met Gln Ile Ala Trp Ser Arg Glu Phe Leu Lys
   1               5                  10                  15      
  Tyr Phe Gly Thr Phe Phe Gly
              20              
  
  
  <210> 30
  <211> 24
  <212> PRT
  <213> Mus musculus
  
  <400> 30
  Ser Arg Glu Phe Leu Lys Tyr Phe Gly Thr Phe Phe Gly Ile Ala Thr
   1               5                  10                  15      
  Ile Ser Leu Ala Thr Gly Ala Leu
              20                  
  
  
  
  
  
  <210> 31
  <211> 20
  <212> PRT
  <213> Mus musculus
  
  <400> 31
  Ala Phe Leu Val Pro Ile Val Pro Leu Ser Phe Ile Phe Thr Tyr Gln
   1               5                  10                  15      
  Tyr Asp Leu Gly
              20  
  
  
  <210> 32
  <211> 10
  <212> PRT
  <213> Mus musculus
  
  <400> 32
  Lys Asp Ser Phe Leu Lys Ser Gln Glu Cys
   1               5                  10  
  
  
  <210> 33
  <211> 10
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> a synthetic peptide
  
  <400> 33
  Cys Glu Gln Ser Lys Leu Phe Ser Asp Lys
   1               5                  10  
  
  
  <210> 34
  <211> 10
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> a synthetic peptide
  
  <400> 34
  Cys Glu Gln Ser Arg Phe Phe Ile Asp Lys
   1               5                  10  
  
  
  <210> 35
  <211> 10
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> a synthetic peptide
  
  <400> 35
  Cys Glu Gln Ser Arg Phe Phe Ile Asp Ala
   1               5                  10  
  
  
  <210> 36
  <211> 10
  <212> PRT
  <213> Artificial Sequence
  
  <220> 
  <223> a synthetic peptide
  
  <400> 36
  Cys Glu Gln Ser Lys Phe Phe Ser Asp Lys
   1               5                  10  
  
  
  <210> 37
  <211> 20
  <212> PRT
  <213> Mus musculus
  
  <400> 37
  Lys Ser Met Asn Glu Asn Met Lys Asn Gln Gln Glu Phe Met Val Thr
   1               5                  10                  15      
  His Ala Arg Leu
              20  
  
  
  <210> 38
  <211> 13
  <212> PRT
  <213> Mus musculus
  
  <400> 38
  Lys Asn Gln Gln Glu Phe Met Val Thr His Ala Arg Leu
   1               5                  10              
  
  
  <210> 39
  <211> 11
  <212> PRT
  <213> Mus musculus
  
  <400> 39
  Arg His Leu Thr Met Gln Asn Glu Met Arg Glu
   1               5                  10      
  
  
  <210> 40
  <211> 15
  <212> PRT
  <213> Mus musculus
  
  <400> 40
  Arg Met Lys Ser Glu Ala Glu Asp Ile Leu Glu Thr Glu Lys Thr
   1               5                  10                  15  
  
  
  
  
  <210> 41
  <211> 22
  <212> PRT
  <213> Mus musculus
  
  <400> 41
  Arg Met Lys Ser Glu Ala Glu Asp Ile Leu Glu Thr Glu Lys Thr Lys
   1               5                  10                  15      
  Leu Glu Leu Pro Lys Gly
              20          
  
  
  <210> 42
  <211> 13
  <212> PRT
  <213> Mus musculus
  
  <400> 42
  Lys Ser Glu Ala Glu Asp Ile Leu Glu Thr Glu Lys Thr
   1               5                  10              
  
  
  
  <210> 43
  <211> 12
  <212> PRT
  <213> Mus musculus
  
  <400> 43
  Lys Gly Leu Ile Thr Phe Glu Ser Leu Glu Lys Ala
   1               5                  10          
  
  
  
  <210> 44
  <211> 14
  <212> PRT
  <213> Mus musculus
  
  <400> 44
  Lys Gly Leu Ile Thr Phe Glu Ser Leu Glu Lys Ala Arg Arg
   1               5                  10                  
  
  
  <210> 45
  <211> 147
  <212> PRT
  <213> Homo sapiens
  
  <400> 45
  Met Gly Phe Ile Phe Ser Lys Ser Met Asn Glu Ser Met Lys Asn Gln
   1               5                  10                  15      
  Lys Glu Phe Met Leu Met Asn Ala Arg Leu Gln Leu Glu Arg Gln Leu
              20                  25                  30          
  Ile Met Gln Ser Glu Met Arg Glu Arg Gln Met Ala Met Arg Ile Ala
          35                  40                  45              
  Trp Ser Arg Glu Phe Leu Lys Tyr Phe Gly Thr Phe Phe Gly Leu Ala
      50                  55                  60                  
  Ala Ile Ser Leu Thr Ala Gly Ala Ile Lys Lys Lys Lys Pro Ala Phe
  65                  70                  75                  80  
  Leu Val Pro Ile Val Pro Leu Ser Phe Ile Leu Thr Tyr Gln Tyr Asp
                  85                  90                  95      
  Leu Gly Tyr Gly Thr Leu Leu Glu Arg Met Lys Gly Glu Ala Glu Asp
              100                 105                 110         
  Ile Leu Glu Thr Glu Lys Ser Lys Leu Gln Leu Pro Arg Gly Met Ile
          115                 120                 125             
  Thr Phe Glu Ser Ile Glu Lys Ala Arg Lys Glu Gln Ser Arg Phe Phe
      130                 135                 140                 
  Ile Asp Lys
  145         
  
  
  
  <210> 46
  <211> 147
  <212> PRT
  <213> Rattus norvegicus
  
  <400> 46
  Met Gly Phe Ile Phe Ser Lys Ser Met Asn Glu Asn Met Lys Asn Gln
   1               5                  10                  15      
  Gln Glu Phe Met Val Met His Ala Arg Leu Gln Leu Glu Arg Gln Leu
              20                  25                  30          
  Ile Met Gln Asn Glu Met Arg Glu Arg Gln Met Ala Met Gln Ile Ala
          35                  40                  45              
  Trp Ser Arg Glu Phe Leu Lys Tyr Phe Gly Thr Phe Phe Gly Ile Ala
      50                  55                  60                  
  Thr Ile Ser Leu Ala Ala Gly Ala Ile Lys Arg Lys Lys Pro Ala Phe
  65                  70                  75                  80  
  Leu Ile Pro Ile Val Pro Leu Ser Phe Ile Phe Thr Tyr Gln Tyr Asp
                  85                  90                  95      
  Leu Gly Tyr Gly Thr Leu Leu Gln Arg Met Lys Ser Glu Ala Glu Asp
              100                 105                 110         
  Ile Leu Glu Thr Glu Lys Thr Lys Leu Glu Leu Pro Lys Gly Leu Ile
          115                 120                 125             
  Thr Phe Glu Ser Leu Glu Lys Ala Arg Arg Glu Gln Ser Lys Phe Phe
      130                 135                 140                 
  Ser Asp Lys
  145         
  
  
  <210> 47
  <211> 147
  <212> PRT
  <213> Canis familiaris
  
  <400> 47
  Met Gly Phe Ile Phe Ser Lys Ser Met Asn Glu Asn Met Lys Asn Gln
   1               5                  10                  15      
  Gln Glu Phe Met Leu Met Asn Ala Arg Leu Gln Met Glu Arg Gln Leu
              20                  25                  30          
  Met Met Gln Asn Glu Met Arg Glu Arg Gln Met Ala Met Gln Ile Ala
          35                  40                  45              
  Trp Ser Arg Glu Phe Leu Lys Tyr Phe Gly Thr Phe Phe Gly Ile Ala
      50                  55                  60                  
  Ala Ile Ser Leu Thr Ala Gly Ala Ile Arg Lys Lys Lys Pro Ala Phe
  65                  70                  75                  80  
  Leu Phe Pro Ile Ile Pro Leu Ser Phe Ile Phe Thr Tyr Gln Tyr Asp
                  85                  90                  95      
  Leu Gly Tyr Gly Thr Leu Leu Gln Arg Met Lys Gly Glu Ala Glu Asn
              100                 105                 110         
  Ile Leu Glu Thr Glu Lys Ser Lys Leu Gln Leu Pro Arg Gly Met Ile
          115                 120                 125             
  Thr Phe Glu Ser Leu Glu Lys Ala Arg Arg Glu Gln Ser Lys Phe Phe
      130                 135                 140                 
  Ile Asp Lys
  145         
  
  
  <210> 48
  <211> 147
  <212> PRT
  <213> Bos taurus
  
  <400> 48
  Met Gly Phe Ile Phe Ser Lys Ser Met Asn Glu Asn Leu Lys Ser Gln
   1               5                  10                  15      
  Gln Glu Phe Met Leu Met Asn Ser Arg Leu Gln Leu Glu Arg Gln Leu
              20                  25                  30          
  Ile Met Gln Asn Glu Met Arg Glu Arg Gln Met Ala Met Gln Ile Ala
          35                  40                  45              
  Trp Ser Arg Glu Phe Leu Lys Tyr Phe Gly Thr Phe Phe Gly Ile Thr
      50                  55                  60                  
  Ala Val Ser Leu Thr Ala Gly Ala Ile Lys Gly Lys Lys Pro Val Leu
  65                  70                  75                  80  
  Ile Phe Pro Ile Val Pro Leu Gly Phe Val Leu Ala Tyr Gln Tyr Asp
                  85                  90                  95      
  Met Gly Tyr Gly Thr Leu Ile His Arg Met Lys Gly Glu Ala Glu Asn
              100                 105                 110         
  Ile Leu Glu Thr Glu Lys Ser Lys Leu Gln Leu Pro Lys Gly Met Ile
          115                 120                 125             
  Thr Phe Glu Ser Leu Glu Lys Ala Arg Lys Glu Gln Ser Lys Phe Phe
      130                 135                 140                 
  Ile Asp Lys
  145         
