                         SEQUENCE LISTING

<110>  Oregon Health & Science University
       McCullough, Amanda
       Lloyd, R Stephen
 
<120>  DNA REPAIR POLYPEPTIDES AND METHODS OF DELIVERY AND USE

<130>  899-77730-02

<150>  61/024,845
<151>  2008-01-30

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  138
<212>  PRT
<213>  Bacteriophage T4

<400>  1

Met Thr Arg Ile Asn Leu Thr Leu Val Ser Glu Leu Ala Asp Gln His 
1               5                   10                  15      


Leu Met Ala Glu Tyr Arg Glu Leu Pro Arg Val Phe Gly Ala Val Arg 
            20                  25                  30          


Lys His Val Ala Asn Gly Lys Arg Val Arg Asp Phe Lys Ile Ser Pro 
        35                  40                  45              


Thr Phe Ile Leu Gly Ala Gly His Val Thr Phe Phe Tyr Asp Lys Leu 
    50                  55                  60                  


Glu Phe Leu Arg Lys Arg Gln Ile Glu Leu Ile Ala Glu Cys Leu Lys 
65                  70                  75                  80  


Arg Gly Phe Asn Ile Lys Asp Thr Thr Val Gln Asp Ile Ser Asp Ile 
                85                  90                  95      


Pro Gln Glu Phe Arg Gly Asp Tyr Ile Pro His Glu Ala Ser Ile Ala 
            100                 105                 110         


Ile Ser Gln Ala Arg Leu Asp Glu Lys Ile Ala Gln Arg Pro Thr Trp 
        115                 120                 125             


Tyr Lys Tyr Tyr Gly Lys Ala Ile Tyr Ala 
    130                 135             


<210>  2
<211>  138
<212>  PRT
<213>  Bacteriophage T4

<400>  2

Met Thr Gln Ile Asn Leu Thr Leu Val Ser Glu Leu Ala Asp Gln His 
1               5                   10                  15      


Leu Met Ala Glu Tyr Arg Glu Leu Pro Arg Val Phe Gly Ala Val Arg 
            20                  25                  30          


Lys His Val Ala Asn Gly Lys Arg Val Arg Asp Phe Lys Ile Ser Pro 
        35                  40                  45              


Thr Phe Ile Leu Gly Ala Gly His Val Thr Phe Phe Tyr Asp Lys Leu 
    50                  55                  60                  


Glu Phe Leu Arg Lys Arg Gln Ile Glu Leu Ile Ala Glu Cys Leu Lys 
65                  70                  75                  80  


Arg Gly Phe Asn Ile Lys Asp Thr Thr Val Gln Asp Ile Ser Asp Ile 
                85                  90                  95      


Pro Gln Glu Phe Arg Gly Asp Tyr Ile Pro His Glu Ala Ser Ile Ala 
            100                 105                 110         


Ile Ser Gln Ala Arg Leu Asp Glu Lys Ile Ala Gln Arg Pro Thr Trp 
        115                 120                 125             


Tyr Lys Tyr Tyr Gly Lys Ala Ile Tyr Ala 
    130                 135             


<210>  3
<211>  138
<212>  PRT
<213>  Bacteriophage T4

<400>  3

Met Thr Arg Ile Asn Leu Thr Leu Val Ser Glu Leu Ala Asp Gln His 
1               5                   10                  15      


Leu Met Ala Glu Tyr Gln Glu Leu Pro Arg Val Phe Gly Ala Val Arg 
            20                  25                  30          


Lys His Val Ala Asn Gly Lys Arg Val Arg Asp Phe Lys Ile Ser Pro 
        35                  40                  45              


Thr Phe Ile Leu Gly Ala Gly His Val Thr Phe Phe Tyr Asp Lys Leu 
    50                  55                  60                  


Glu Phe Leu Arg Lys Arg Gln Ile Glu Leu Ile Ala Glu Cys Leu Lys 
65                  70                  75                  80  


Arg Gly Phe Asn Ile Lys Asp Thr Thr Val Gln Asp Ile Ser Asp Ile 
                85                  90                  95      


Pro Gln Glu Phe Arg Gly Asp Tyr Ile Pro His Glu Ala Ser Ile Ala 
            100                 105                 110         


Ile Ser Gln Ala Arg Leu Asp Glu Lys Ile Ala Gln Arg Pro Thr Trp 
        115                 120                 125             


Tyr Lys Tyr Tyr Gly Lys Ala Ile Tyr Ala 
    130                 135             


<210>  4
<211>  138
<212>  PRT
<213>  Bacteriophage T4

<400>  4

Met Thr Arg Ile Asn Leu Thr Leu Val Ser Glu Leu Ala Asp Gln His 
1               5                   10                  15      


Leu Met Ala Glu Tyr Arg Glu Leu Pro Gln Val Phe Gly Ala Val Arg 
            20                  25                  30          


Lys His Val Ala Asn Gly Lys Arg Val Arg Asp Phe Lys Ile Ser Pro 
        35                  40                  45              


Thr Phe Ile Leu Gly Ala Gly His Val Thr Phe Phe Tyr Asp Lys Leu 
    50                  55                  60                  


Glu Phe Leu Arg Lys Arg Gln Ile Glu Leu Ile Ala Glu Cys Leu Lys 
65                  70                  75                  80  


Arg Gly Phe Asn Ile Lys Asp Thr Thr Val Gln Asp Ile Ser Asp Ile 
                85                  90                  95      


Pro Gln Glu Phe Arg Gly Asp Tyr Ile Pro His Glu Ala Ser Ile Ala 
            100                 105                 110         


Ile Ser Gln Ala Arg Leu Asp Glu Lys Ile Ala Gln Arg Pro Thr Trp 
        115                 120                 125             


Tyr Lys Tyr Tyr Gly Lys Ala Ile Tyr Ala 
    130                 135             


<210>  5
<211>  138
<212>  PRT
<213>  Bacteriophage T4

<400>  5

Met Thr Arg Ile Asn Leu Thr Leu Val Ser Glu Leu Ala Asp Gln His 
1               5                   10                  15      


Leu Met Ala Glu Tyr Arg Glu Leu Pro Arg Val Phe Gly Ala Val Arg 
            20                  25                  30          


Lys His Val Ala Asn Gly Lys Arg Val Arg Asp Phe Lys Ile Ser Pro 
        35                  40                  45              


Thr Phe Ile Leu Gly Ala Gly His Val Thr Phe Phe Tyr Asp Lys Leu 
    50                  55                  60                  


Glu Phe Leu Arg Lys Arg Gln Ile Glu Leu Ile Ala Glu Cys Leu Lys 
65                  70                  75                  80  


Arg Gly Phe Asn Ile Lys Asp Thr Thr Val Gln Asp Ile Ser Asp Ile 
                85                  90                  95      


Pro Gln Glu Phe Arg Gly Asp Tyr Ile Pro His Glu Ala Ser Ile Ala 
            100                 105                 110         


Ile Ser Gln Ala Gln Leu Asp Glu Lys Ile Ala Gln Arg Pro Thr Trp 
        115                 120                 125             


Tyr Lys Tyr Tyr Gly Lys Ala Ile Tyr Ala 
    130                 135             


<210>  6
<211>  141
<212>  PRT
<213>  Chlorella virus-1

<400>  6

Met Thr Arg Val Asn Leu Val Pro Val Gln Glu Leu Ala Asp Gln His 
1               5                   10                  15      


Leu Met Ala Glu Phe Arg Glu Leu Lys Met Ile Pro Lys Ala Leu Ala 
            20                  25                  30          


Arg Ser Leu Arg Thr Gln Ser Ser Glu Lys Ile Leu Lys Lys Ile Pro 
        35                  40                  45              


Ser Lys Phe Thr Leu Asn Thr Gly His Val Leu Phe Phe Tyr Asp Lys 
    50                  55                  60                  


Gly Lys Tyr Leu Gln Gln Arg Tyr Asp Glu Ile Val Val Glu Leu Val 
65                  70                  75                  80  


Asp Arg Gly Tyr Lys Ile Asn Val Asp Ala Lys Leu Asp Pro Asp Asn 
                85                  90                  95      


Val Met Thr Gly Glu Trp Tyr Asn Asp Tyr Thr Pro Thr Glu Asp Ala 
            100                 105                 110         


Phe Asn Ile Ile Arg Ala Arg Ile Ala Glu Lys Ile Ala Met Lys Pro 
        115                 120                 125             


Ser Phe Tyr Arg Phe Thr Lys Ala Lys Thr Ser Asn Asn 
    130                 135                 140     


<210>  7
<211>  141
<212>  PRT
<213>  Chlorella virus-1

<400>  7

Met Thr Gln Val Asn Leu Val Pro Val Gln Glu Leu Ala Asp Gln His 
1               5                   10                  15      


Leu Met Ala Glu Phe Arg Glu Leu Lys Met Ile Pro Lys Ala Leu Ala 
            20                  25                  30          


Arg Ser Leu Arg Thr Gln Ser Ser Glu Lys Ile Leu Lys Lys Ile Pro 
        35                  40                  45              


Ser Lys Phe Thr Leu Asn Thr Gly His Val Leu Phe Phe Tyr Asp Lys 
    50                  55                  60                  


Gly Lys Tyr Leu Gln Gln Arg Tyr Asp Glu Ile Val Val Glu Leu Val 
65                  70                  75                  80  


Asp Arg Gly Tyr Lys Ile Asn Val Asp Ala Lys Leu Asp Pro Asp Asn 
                85                  90                  95      


Val Met Thr Gly Glu Trp Tyr Asn Asp Tyr Thr Pro Thr Glu Asp Ala 
            100                 105                 110         


Phe Asn Ile Ile Arg Ala Arg Ile Ala Glu Lys Ile Ala Met Lys Pro 
        115                 120                 125             


Ser Phe Tyr Arg Phe Thr Lys Ala Lys Thr Ser Asn Asn 
    130                 135                 140     


<210>  8
<211>  141
<212>  PRT
<213>  Chlorella virus-1

<400>  8

Met Thr Arg Val Asn Leu Val Pro Val Gln Glu Leu Ala Asp Gln His 
1               5                   10                  15      


Leu Met Ala Glu Phe Gln Glu Leu Lys Met Ile Pro Lys Ala Leu Ala 
            20                  25                  30          


Arg Ser Leu Arg Thr Gln Ser Ser Glu Lys Ile Leu Lys Lys Ile Pro 
        35                  40                  45              


Ser Lys Phe Thr Leu Asn Thr Gly His Val Leu Phe Phe Tyr Asp Lys 
    50                  55                  60                  


Gly Lys Tyr Leu Gln Gln Arg Tyr Asp Glu Ile Val Val Glu Leu Val 
65                  70                  75                  80  


Asp Arg Gly Tyr Lys Ile Asn Val Asp Ala Lys Leu Asp Pro Asp Asn 
                85                  90                  95      


Val Met Thr Gly Glu Trp Tyr Asn Asp Tyr Thr Pro Thr Glu Asp Ala 
            100                 105                 110         


Phe Asn Ile Ile Arg Ala Arg Ile Ala Glu Lys Ile Ala Met Lys Pro 
        115                 120                 125             


Ser Phe Tyr Arg Phe Thr Lys Ala Lys Thr Ser Asn Asn 
    130                 135                 140     


<210>  9
<211>  141
<212>  PRT
<213>  Chlorella virus-1

<400>  9

Met Thr Arg Val Asn Leu Val Pro Val Gln Glu Leu Ala Asp Gln His 
1               5                   10                  15      


Leu Met Ala Glu Phe Arg Glu Leu Lys Met Ile Pro Lys Ala Leu Ala 
            20                  25                  30          


Arg Ser Leu Arg Thr Gln Ser Ser Glu Lys Ile Leu Lys Lys Ile Pro 
        35                  40                  45              


Ser Lys Phe Thr Leu Asn Thr Gly His Val Leu Phe Phe Tyr Asp Lys 
    50                  55                  60                  


Gly Lys Tyr Leu Gln Gln Arg Tyr Asp Glu Ile Val Val Glu Leu Val 
65                  70                  75                  80  


Asp Arg Gly Tyr Lys Ile Asn Val Asp Ala Lys Leu Asp Pro Asp Asn 
                85                  90                  95      


Val Met Thr Gly Glu Trp Tyr Asn Asp Tyr Thr Pro Thr Glu Asp Ala 
            100                 105                 110         


Phe Asn Ile Ile Gln Ala Arg Ile Ala Glu Lys Ile Ala Met Lys Pro 
        115                 120                 125             


Ser Phe Tyr Arg Phe Thr Lys Ala Lys Thr Ser Asn Asn 
    130                 135                 140     


<210>  10
<211>  141
<212>  PRT
<213>  Chlorella virus-1

<400>  10

Met Thr Arg Val Asn Leu Val Pro Val Gln Glu Leu Ala Asp Gln His 
1               5                   10                  15      


Leu Met Ala Glu Phe Arg Glu Leu Lys Met Ile Pro Lys Ala Leu Ala 
            20                  25                  30          


Arg Ser Leu Arg Thr Gln Ser Ser Glu Lys Ile Leu Lys Lys Ile Pro 
        35                  40                  45              


Ser Lys Phe Thr Leu Asn Thr Gly His Val Leu Phe Phe Tyr Asp Lys 
    50                  55                  60                  


Gly Lys Tyr Leu Gln Gln Arg Tyr Asp Glu Ile Val Val Glu Leu Val 
65                  70                  75                  80  


Asp Arg Gly Tyr Lys Ile Asn Val Asp Ala Lys Leu Asp Pro Asp Asn 
                85                  90                  95      


Val Met Thr Gly Glu Trp Tyr Asn Asp Tyr Thr Pro Thr Glu Asp Ala 
            100                 105                 110         


Phe Asn Ile Ile Arg Ala Gln Ile Ala Glu Lys Ile Ala Met Lys Pro 
        115                 120                 125             


Ser Phe Tyr Arg Phe Thr Lys Ala Lys Thr Ser Asn Asn 
    130                 135                 140     


<210>  11
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  11

Pro Lys Lys Arg Lys Arg Arg Leu 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  12

Pro Lys Lys Lys Arg Lys Arg Leu 
1               5               


<210>  13
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  13

Met Ala Leu His Ser Met Arg Lys Ala Arg Glu Arg Trp Ser Phe Ile 
1               5                   10                  15      


Arg Ala 
        


<210>  14
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  14

Met Gly Val Phe Cys Leu Gly Phe Trp Gly Leu Gly Arg Lys Leu Arg 
1               5                   10                  15      


Thr Phe Gly Lys Gly Pro Lys Gln Leu Leu Ser Arg Leu Cys Gly Asp 
            20                  25                  30          


His Leu Gln 
        35  


<210>  15
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  15

Met Gly Val Phe Cys Leu Gly Phe Trp Gly Leu Gly Arg Lys Leu Arg 
1               5                   10                  15      


Thr Phe Gly Lys Gly Pro Leu Gln Leu Leu Ser Arg Leu 
            20                  25                  


<210>  16
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  16
cttgcccata tgacacgtgt gaatctcgta                                        30


<210>  17
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  17
cttgcccata tgggcgtgtt ttgcttaggc                                        30


<210>  18
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  18
cagttattat cgcgcttaac acgtgtgaat ctcgta                                 36


<210>  19
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  19
ccaaagaaga ggaaaaggag gctaggatcc atcgccacc                              39


<210>  20
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  20
ccaaagaaga ggaaaaggag gctaaagctt tatggccgc                              39


<210>  21
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  21
gcggccgcta agcttattat tgctggtttt agcttt                                 36


<210>  22
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  22
gcggccgcta agctttagcc tcttcctctt tttctt                                 36


<210>  23
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  23
gcggccgcta agcttgtaca gctcgtccat gcc                                    33


<210>  24
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  24
tacgagattc acacgtgtta agcgcgataa taactg                                 36


<210>  25
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  25
tagcctcctt ttcctcttct ttggcccggg attattgct                              39


<210>  26
<211>  426
<212>  DNA
<213>  Chlorella virus-1

<400>  26
atgacacgtg tgaatctcgt accggttcaa gaattagctg accagcatct catggcagaa       60

tttcgtgaac ttaagatgat tccgaaggca ctcgcaagaa gtcttcgaac tcaatcgtcc      120

gaaaaaatat tgaagaagat cccatcaaaa tttactctga acactggtca tgttctgttc      180

ttttacgata aaggcaagta tttgcaacaa cgatacgacg aaattgtcgt tgaacttgtt      240

gatagggggt ataagataaa cgttgacgct aaactcgacc ctgataacgt gatgacggga      300

gagtggtaca atgattacac cccaacagaa gatgcgttta atattattcg agcgaggatt      360

gccgaaaaaa tcgctatgaa gccaagtttt tacaggttca cgaaagctaa aaccagcaat      420

aattaa                                                                 426


<210>  27
<211>  417
<212>  DNA
<213>  Bacteriophage T4

<400>  27
atgactcgta tcaaccttac tttagtatct gaattggctg accaacactt aatggctgaa       60

tatcgtgaat tgccgcgtgt ttttggtgca gttcgtaagc atgttgctaa cggtaaacgt      120

gttcgtgatt ttaaaatcag tcctactttt atccttggcg caggtcatgt tacattcttt      180

tacgataagc tcgagttctt acgtaaacgt caaattgagc ttatagctga atgtttaaaa      240

cgtggtttta atatcaagga tactacagtc caggatatta gtgatattcc tcaggaattc      300

cgtggtgatt atattcccca tgaagcttct attgctatat cacaagctcg tttagatgaa      360

aaaattgcac aacgtcctac ttggtacaaa tactacggta aggcgattta tgcataa         417


<210>  28
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  28

Pro Lys Lys Lys Arg Lys Val Cys 
1               5               


<210>  29
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  29

Gly Lys Lys Lys Tyr Lys Leu Lys His 
1               5                   


<210>  30
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  30

Lys Ser Lys Lys Lys Ala Gln 
1               5           


<210>  31
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  31

Lys Glu Leu Lys Gln Lys Gln Ile Thr Lys 
1               5                   10  


<210>  32
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  32

Asn Glu Trp Thr Leu Glu Leu Leu Glu Glu Leu Lys Asn Glu Ala Val 
1               5                   10                  15      


Arg His Phe 
            


<210>  33
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  33

Arg His Ser Arg Ile Gly Val Thr Arg Gly Arg Arg Ala Arg Asn Gly 
1               5                   10                  15      


Ala Ser Arg Ser 
            20  


<210>  34
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  34

Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg 
1               5                   10          


<210>  35
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  35

Gly Lys Lys Arg Ser Lys Val 
1               5           


<210>  36
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  36

Lys Ser Arg Lys Arg Lys Leu 
1               5           


<210>  37
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  37

Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys Leu 
1               5                   10                  15      


Asp Lys 
        


<210>  38
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  38

Arg Lys Lys Arg Lys Thr Glu Glu Glu Ser Pro Leu Lys Asp Lys Ala 
1               5                   10                  15      


Lys Lys Ser Lys 
            20  


<210>  39
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide nuclear localization signal

<400>  39

Lys Lys Tyr Glu Asn Val Val Ile Lys Arg Ser Pro Arg Lys Arg Gly 
1               5                   10                  15      


Arg Pro Arg Lys 
            20  


<210>  40
<211>  11
<212>  PRT
<213>  Human immunodeficiency virus

<400>  40

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  41
<211>  9
<212>  PRT
<213>  Human immunodeficiency virus

<400>  41

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Human immunodeficiency virus

<400>  42

Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Human immunodeficiency virus

<400>  43

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


