                         SEQUENCE LISTING

<110>  Anderson, Robert E.
       Agbaga, Martin-Paul
       Brush, Richard S.
 
<120>  VERY LONG CHAIN POLYUNSATURATED FATTY ACIDS, METHODS OF 
       PRODUCTION, AND USES

<130>  5835.105wo

<150>  61/062,579
<151>  2008-01-28

<160>  20    

<170>  PatentIn version 3.3

<210>  1
<211>  945
<212>  DNA
<213>  Homo sapiens

<400>  1
atggggctcc tggactcgga gccgggtagt gtcctaaacg tagtgtccac ggcactcaac     60

gacacggtag agttctaccg ctggacctgg tccatcgcag ataagcgtgt ggaaaattgg    120

cctctgatgc agtctccttg gcctacacta agtataagca ctctttatct cctgtttgtg    180

tggctgggtc caaaatggat gaaggaccga gaaccttttc agatgcgtct agtgctcatt    240

atctataatt ttgggatggt tttgcttaac ctctttatct tcagagagtt attcatggga    300

tcatataatg cgggatatag ctatatttgc cagagtgtgg attattctaa taatgttcat    360

gaagtcagga tagctgctgc tctgtggtgg tactttgtat ctaaaggagt tgagtatttg    420

gacacagtgt tttttattct gagaaagaaa aacaaccaag tttctttcct tcatgtgtat    480

catcactgta cgatgtttac cttgtggtgg attggaatta agtgggttgc aggaggacaa    540

gcattttttg gagcccagtt gaattccttt atccatgtga ttatgtactc atactatggg    600

ttaactgcat ttggcccatg gattcagaaa tatctttggt ggaaacgata cctgactatg    660

ttgcaactga ttcaattcca tgtgaccatt gggcacacgg cactgtctct ttacactgac    720

tgccccttcc ccaaatggat gcactgggct ctaattgcct atgcaatcag cttcatattt    780

ctctttctta acttctacat tcggacatac aaagagccta agaaaccaaa agctggaaaa    840

acagccatga atggtatttc agcaaatggt gtgagcaaat cagaaaaaca actcatgata    900

gaaaatggaa aaaagcagaa aaatggaaaa gcaaaaggag attaa                    945


<210>  2
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Leu Leu Asp Ser Glu Pro Gly Ser Val Leu Asn Val Val Ser 
1               5                   10                  15      


Thr Ala Leu Asn Asp Thr Val Glu Phe Tyr Arg Trp Thr Trp Ser Ile 
            20                  25                  30          


Ala Asp Lys Arg Val Glu Asn Trp Pro Leu Met Gln Ser Pro Trp Pro 
        35                  40                  45              


Thr Leu Ser Ile Ser Thr Leu Tyr Leu Leu Phe Val Trp Leu Gly Pro 
    50                  55                  60                  


Lys Trp Met Lys Asp Arg Glu Pro Phe Gln Met Arg Leu Val Leu Ile 
65                  70                  75                  80  


Ile Tyr Asn Phe Gly Met Val Leu Leu Asn Leu Phe Ile Phe Arg Glu 
                85                  90                  95      


Leu Phe Met Gly Ser Tyr Asn Ala Gly Tyr Ser Tyr Ile Cys Gln Ser 
            100                 105                 110         


Val Asp Tyr Ser Asn Asn Val His Glu Val Arg Ile Ala Ala Ala Leu 
        115                 120                 125             


Trp Trp Tyr Phe Val Ser Lys Gly Val Glu Tyr Leu Asp Thr Val Phe 
    130                 135                 140                 


Phe Ile Leu Arg Lys Lys Asn Asn Gln Val Ser Phe Leu His Val Tyr 
145                 150                 155                 160 


His His Cys Thr Met Phe Thr Leu Trp Trp Ile Gly Ile Lys Trp Val 
                165                 170                 175     


Ala Gly Gly Gln Ala Phe Phe Gly Ala Gln Leu Asn Ser Phe Ile His 
            180                 185                 190         


Val Ile Met Tyr Ser Tyr Tyr Gly Leu Thr Ala Phe Gly Pro Trp Ile 
        195                 200                 205             


Gln Lys Tyr Leu Trp Trp Lys Arg Tyr Leu Thr Met Leu Gln Leu Ile 
    210                 215                 220                 


Gln Phe His Val Thr Ile Gly His Thr Ala Leu Ser Leu Tyr Thr Asp 
225                 230                 235                 240 


Cys Pro Phe Pro Lys Trp Met His Trp Ala Leu Ile Ala Tyr Ala Ile 
                245                 250                 255     


Ser Phe Ile Phe Leu Phe Leu Asn Phe Tyr Ile Arg Thr Tyr Lys Glu 
            260                 265                 270         


Pro Lys Lys Pro Lys Ala Gly Lys Thr Ala Met Asn Gly Ile Ser Ala 
        275                 280                 285             


Asn Gly Val Ser Lys Ser Glu Lys Gln Leu Met Ile Glu Asn Gly Lys 
    290                 295                 300                 


Lys Gln Lys Asn Gly Lys Ala Lys Gly Asp 
305                 310                 


<210>  3
<211>  939
<212>  DNA
<213>  Mus Musculus

<400>  3
atggggctgc tggactcaga gcccggcagc gtcctgaacg cgatgtccac ggcattcaac     60

gacaccgtgg agttctatcg ctggacctgg accattgcag ataaacgtgt agcagactgg    120

ccgctgatgc agtctccatg gccaacgata agcataagca cgctctatct cctgttcgtg    180

tggctgggtc caaagtggat gaaagaccgc gagccgttcc aaatgcgctt agtactcata    240

atctataatt ttggcatggt tttgcttaac cttttcatct tcagagagct attcatggga    300

tcatacaacg caggatacag ctatatttgc cagtcagtgg attattctaa tgatgttaat    360

gaagtcagga tagcggcggc cctgtggtgg tattttgtat cgaaaggcgt tgagtatttg    420

gacacagtgt tttttatcct gaggaagaaa aacaaccaag tctccttcct tcacgtgtac    480

caccactgca ccatgttcac tctgtggtgg attggaatca agtgggtggc tggaggccaa    540

gcgtttttcg gggcccagat gaactctttc atccacgtga tcatgtactc ctactatggg    600

ctgactgcgt tcggcccctg gatccagaaa tatctttggt ggaagcgata cctgaccatg    660

ctgcagctgg tccagttcca cgtgaccatc ggacacacag cactgtctct ctacaccgac    720

tgccccttcc ccaagtggat gcactgggct ctgatcgcct acgccatcag cttcatcttc    780

ctcttcctca acttctacac tcggacatac aatgagccga agcagtcaaa aaccggaaag    840

acggccacga atggtatctc atcgaacggc gtgaataaat cagagaaagc gttagaaaac    900

gggaaacccc agaaaaacgg gaagccaaaa ggagagtaa                           939


<210>  4
<211>  312
<212>  PRT
<213>  Mus Musculus

<400>  4

Met Gly Leu Leu Asp Ser Glu Pro Gly Ser Val Leu Asn Ala Met Ser 
1               5                   10                  15      


Thr Ala Phe Asn Asp Thr Val Glu Phe Tyr Arg Trp Thr Trp Thr Ile 
            20                  25                  30          


Ala Asp Lys Arg Val Ala Asp Trp Pro Leu Met Gln Ser Pro Trp Pro 
        35                  40                  45              


Thr Ile Ser Ile Ser Thr Leu Tyr Leu Leu Phe Val Trp Leu Gly Pro 
    50                  55                  60                  


Lys Trp Met Lys Asp Arg Glu Pro Phe Gln Met Arg Leu Val Leu Ile 
65                  70                  75                  80  


Ile Tyr Asn Phe Gly Met Val Leu Leu Asn Leu Phe Ile Phe Arg Glu 
                85                  90                  95      


Leu Phe Met Gly Ser Tyr Asn Ala Gly Tyr Ser Tyr Ile Cys Gln Ser 
            100                 105                 110         


Val Asp Tyr Ser Asn Asp Val Asn Glu Val Arg Ile Ala Ala Ala Leu 
        115                 120                 125             


Trp Trp Tyr Phe Val Ser Lys Gly Val Glu Tyr Leu Asp Thr Val Phe 
    130                 135                 140                 


Phe Ile Leu Arg Lys Lys Asn Asn Gln Val Ser Phe Leu His Val Tyr 
145                 150                 155                 160 


His His Cys Thr Met Phe Thr Leu Trp Trp Ile Gly Ile Lys Trp Val 
                165                 170                 175     


Ala Gly Gly Gln Ala Phe Phe Gly Ala Gln Met Asn Ser Phe Ile His 
            180                 185                 190         


Val Ile Met Tyr Ser Tyr Tyr Gly Leu Thr Ala Phe Gly Pro Trp Ile 
        195                 200                 205             


Gln Lys Tyr Leu Trp Trp Lys Arg Tyr Leu Thr Met Leu Gln Leu Val 
    210                 215                 220                 


Gln Phe His Val Thr Ile Gly His Thr Ala Leu Ser Leu Tyr Thr Asp 
225                 230                 235                 240 


Cys Pro Phe Pro Lys Trp Met His Trp Ala Leu Ile Ala Tyr Ala Ile 
                245                 250                 255     


Ser Phe Ile Phe Leu Phe Leu Asn Phe Tyr Thr Arg Thr Tyr Asn Glu 
            260                 265                 270         


Pro Lys Gln Ser Lys Thr Gly Lys Thr Ala Thr Asn Gly Ile Ser Ser 
        275                 280                 285             


Asn Gly Val Asn Lys Ser Glu Lys Ala Leu Glu Asn Gly Lys Pro Gln 
    290                 295                 300                 


Lys Asn Gly Lys Pro Lys Gly Glu 
305                 310         


<210>  5
<211>  945
<212>  DNA
<213>  Macaca

<400>  5
atggggctcc tggactcgga gccgggtagt gtcctaaacg tagtgtccac ggcactcaac     60

gacacggtgg agttctaccg ctggacctgg tccatcgcag ataagcgtgt ggagaattgg    120

cctctgatgc agtctccttg gcctacacta agtataagca ctctttatct cctgtttgtg    180

tggctgggtc caaagtggat gaaggaccga gaaccttttc agatgcgtct agtgctcatt    240

atctataatt ttgggatggt tttgcttaac ttttttatct tcagagagtt attcatggga    300

tcatataatg cgggatatag ctatatttgc cagagtgtgg attattctaa taatgttaat    360

gaagtcagga tagctgctgc tctgtggtgg tactttgttt ctaaaggagt tgagtatttg    420

gacacagtgt tttttattct gagaaagaaa aacaaccagg tttctttcct tcatgtgtat    480

catcactgta cgatgtttac cttgtggtgg attggaatta agtgggttgc aggaggacaa    540

gcattttttg gagcccagat gaattccttt atccatgtga ttatgtactc atactatggg    600

ttagctgcat ttggcccatg gattcagaaa tatctttggt ggaaacgata cctgactatg    660

ttgcaactgg ttcaattcca tgtgaccatt gggcacacag cactgtctct ttacactgac    720

tgccccttcc ccaaatggat gcactgggct ctaattgcct acgcaatcag cttcatattt    780

ctctttctta acttctacat tcggacatac aaagagccta agaaaccaaa aactggaaaa    840

acagccatga atggtatttc agcaaatggt gtgagcaaat cagaaaaaca actcgtgata    900

gaaaacggaa aaaagcagaa aaatggaaaa gcaaaaggag attaa                    945


<210>  6
<211>  314
<212>  PRT
<213>  Macaca

<400>  6

Met Gly Leu Leu Asp Ser Glu Pro Gly Ser Val Leu Asn Val Val Ser 
1               5                   10                  15      


Thr Ala Leu Asn Asp Thr Val Glu Phe Tyr Arg Trp Thr Trp Ser Ile 
            20                  25                  30          


Ala Asp Lys Arg Val Glu Asn Trp Pro Leu Met Gln Ser Pro Trp Pro 
        35                  40                  45              


Thr Leu Ser Ile Ser Thr Leu Tyr Leu Leu Phe Val Trp Leu Gly Pro 
    50                  55                  60                  


Lys Trp Met Lys Asp Arg Glu Pro Phe Gln Met Arg Leu Val Leu Ile 
65                  70                  75                  80  


Ile Tyr Asn Phe Gly Met Val Leu Leu Asn Phe Phe Ile Phe Arg Glu 
                85                  90                  95      


Leu Phe Met Gly Ser Tyr Asn Ala Gly Tyr Ser Tyr Ile Cys Gln Ser 
            100                 105                 110         


Val Asp Tyr Ser Asn Asn Val Asn Glu Val Arg Ile Ala Ala Ala Leu 
        115                 120                 125             


Trp Trp Tyr Phe Val Ser Lys Gly Val Glu Tyr Leu Asp Thr Val Phe 
    130                 135                 140                 


Phe Ile Leu Arg Lys Lys Asn Asn Gln Val Ser Phe Leu His Val Tyr 
145                 150                 155                 160 


His His Cys Thr Met Phe Thr Leu Trp Trp Ile Gly Ile Lys Trp Val 
                165                 170                 175     


Ala Gly Gly Gln Ala Phe Phe Gly Ala Gln Met Asn Ser Phe Ile His 
            180                 185                 190         


Val Ile Met Tyr Ser Tyr Tyr Gly Leu Ala Ala Phe Gly Pro Trp Ile 
        195                 200                 205             


Gln Lys Tyr Leu Trp Trp Lys Arg Tyr Leu Thr Met Leu Gln Leu Val 
    210                 215                 220                 


Gln Phe His Val Thr Ile Gly His Thr Ala Leu Ser Leu Tyr Thr Asp 
225                 230                 235                 240 


Cys Pro Phe Pro Lys Trp Met His Trp Ala Leu Ile Ala Tyr Ala Ile 
                245                 250                 255     


Ser Phe Ile Phe Leu Phe Leu Asn Phe Tyr Ile Arg Thr Tyr Lys Glu 
            260                 265                 270         


Pro Lys Lys Pro Lys Thr Gly Lys Thr Ala Met Asn Gly Ile Ser Ala 
        275                 280                 285             


Asn Gly Val Ser Lys Ser Glu Lys Gln Leu Val Ile Glu Asn Gly Lys 
    290                 295                 300                 


Lys Gln Lys Asn Gly Lys Ala Lys Gly Asp 
305                 310                 


<210>  7
<211>  945
<212>  DNA
<213>  Bos taurus

<400>  7
atggggctcc tggactcgga gccgggcagc gtcctgaacg cggtgtccac ggcgctgaac     60

gacaccgtgg agttctaccg ctggaccttg tccatcacag ataaacgcgt cgagaactgg    120

cctctgatgc agtctccact gcctacactt tgcataagca ccctgtacct cctcttcgtg    180

tggctgggtc caaaatggat gaaggaccga gaacctttcc agatgcgttt agtgctcatt    240

ctctataatt tcgggatggt tttgcttaac ctttttatct tcagagagtt actcatggga    300

tcatataatg caggatatag ctatatttgc cagactgtgg attattctga taacgttcat    360

gaagtcagga tagctgctgc tctgtggtgg tactttatat ctaaaggaat tgagtatttg    420

gacacggtgt tttttatcct gaggaagaaa aacaaccaag tctcttttct tcacgtgtat    480

catcactgta ccatgtttac gttgtggtgg attggaatta agtgggttgc aggaggacag    540

gcattttttg gagcccagat aaattccttc atccatgtga ttatgtattc atactatggg    600

ttagctgcct tcggcccgtg gattcagaaa tatctctggt ggaaacgata cctgaccatg    660

ttgcagctgg ttcagttcca cgtgaccatt gggcacacag cactgtccct ttacaccgac    720

tgccccttcc ccaagtggat gcactgggct ctcattgtct atgcagtcag cttcatattc    780

ctcttcctta acttctatgt gcggacgtac aaagagccta agaaagcaaa acccggaaaa    840

acagcaacga atggtatttc agctaatggt gtgaacaaat ccgaaaacca cctagtggta    900

gaaaatggca agaagcagaa gaatggaaaa gcaaaaggag agtaa                    945


<210>  8
<211>  314
<212>  PRT
<213>  Bos taurus

<400>  8

Met Gly Leu Leu Asp Ser Glu Pro Gly Ser Val Leu Asn Ala Val Ser 
1               5                   10                  15      


Thr Ala Leu Asn Asp Thr Val Glu Phe Tyr Arg Trp Thr Leu Ser Ile 
            20                  25                  30          


Thr Asp Lys Arg Val Glu Asn Trp Pro Leu Met Gln Ser Pro Leu Pro 
        35                  40                  45              


Thr Leu Cys Ile Ser Thr Leu Tyr Leu Leu Phe Val Trp Leu Gly Pro 
    50                  55                  60                  


Lys Trp Met Lys Asp Arg Glu Pro Phe Gln Met Arg Leu Val Leu Ile 
65                  70                  75                  80  


Leu Tyr Asn Phe Gly Met Val Leu Leu Asn Leu Phe Ile Phe Arg Glu 
                85                  90                  95      


Leu Leu Met Gly Ser Tyr Asn Ala Gly Tyr Ser Tyr Ile Cys Gln Thr 
            100                 105                 110         


Val Asp Tyr Ser Asp Asn Val His Glu Val Arg Ile Ala Ala Ala Leu 
        115                 120                 125             


Trp Trp Tyr Phe Ile Ser Lys Gly Ile Glu Tyr Leu Asp Thr Val Phe 
    130                 135                 140                 


Phe Ile Leu Arg Lys Lys Asn Asn Gln Val Ser Phe Leu His Val Tyr 
145                 150                 155                 160 


His His Cys Thr Met Phe Thr Leu Trp Trp Ile Gly Ile Lys Trp Val 
                165                 170                 175     


Ala Gly Gly Gln Ala Phe Phe Gly Ala Gln Ile Asn Ser Phe Ile His 
            180                 185                 190         


Val Ile Met Tyr Ser Tyr Tyr Gly Leu Ala Ala Phe Gly Pro Trp Ile 
        195                 200                 205             


Gln Lys Tyr Leu Trp Trp Lys Arg Tyr Leu Thr Met Leu Gln Leu Val 
    210                 215                 220                 


Gln Phe His Val Thr Ile Gly His Thr Ala Leu Ser Leu Tyr Thr Asp 
225                 230                 235                 240 


Cys Pro Phe Pro Lys Trp Met His Trp Ala Leu Ile Val Tyr Ala Val 
                245                 250                 255     


Ser Phe Ile Phe Leu Phe Leu Asn Phe Tyr Val Arg Thr Tyr Lys Glu 
            260                 265                 270         


Pro Lys Lys Ala Lys Pro Gly Lys Thr Ala Thr Asn Gly Ile Ser Ala 
        275                 280                 285             


Asn Gly Val Asn Lys Ser Glu Asn His Leu Val Val Glu Asn Gly Lys 
    290                 295                 300                 


Lys Gln Lys Asn Gly Lys Ala Lys Gly Glu 
305                 310                 


<210>  9
<211>  945
<212>  DNA
<213>  Equus caballus

<400>  9
atggggctcc tggacgcgga gccaggcagt gtcctgaacg tggtgtccac ggcgctcaac     60

gacaccgtgg agttgtaccg ctggacctgt tctttcgcag ataagcgtgt ggaaaactgg    120

cctctgatgc agtccccatg gactacgctt ggtatcagca ctctttatct cctgttcgtg    180

tggctgggtc caaaatggat gaaggaccga gagccttttc agatgcgctt agtgctcatt    240

atctataatt ttggcatggt tttccttaac ctttttatct tcagagagtt attcatggga    300

tcatataatg caggatatag ctatatttgc cagactgtgg attattctga taatgttcac    360

gaagtcagga tagctgctgc tctgtggtgg tactttgtgt ctaaaggagt ggagtattta    420

gacacggtgt tttttatctt gaggaagaaa aacaatcaag tctctttcct tcatgtatat    480

catcactgta caatgtttac gttgtggtgg attggaatta agtgggtcgc agggggacaa    540

gcttttttcg gagcccagat gaattccctc atccatgtga ttatgtactc ctactacggc    600

ttaagtgcgt ttggcccatg gattcagaag tatctttggt ggaaacgata cctgactatg    660

ttgcagctga tccagttcca tgtgaccatt ggccacacag cactgtctct gtacacggat    720

tgccctttcc ccaaatggat gcactgggct ctcattgtct attcaatcag cttcatactt    780

ctctttctta acttctatgt tcggacatac aacatgccta agaaatccca aactggaaaa    840

ccagctgtga atggtatttc agcaaatggt gtgagcaaat cagaaaaaca gctagtgatg    900

gaaaatggaa aaaagcagaa aactggaaaa gcaaaaggag agtaa                    945


<210>  10
<211>  314
<212>  PRT
<213>  Equus caballus

<400>  10

Met Gly Leu Leu Asp Ala Glu Pro Gly Ser Val Leu Asn Val Val Ser 
1               5                   10                  15      


Thr Ala Leu Asn Asp Thr Val Glu Leu Tyr Arg Trp Thr Cys Ser Phe 
            20                  25                  30          


Ala Asp Lys Arg Val Glu Asn Trp Pro Leu Met Gln Ser Pro Trp Thr 
        35                  40                  45              


Thr Leu Gly Ile Ser Thr Leu Tyr Leu Leu Phe Val Trp Leu Gly Pro 
    50                  55                  60                  


Lys Trp Met Lys Asp Arg Glu Pro Phe Gln Met Arg Leu Val Leu Ile 
65                  70                  75                  80  


Ile Tyr Asn Phe Gly Met Val Phe Leu Asn Leu Phe Ile Phe Arg Glu 
                85                  90                  95      


Leu Phe Met Gly Ser Tyr Asn Ala Gly Tyr Ser Tyr Ile Cys Gln Thr 
            100                 105                 110         


Val Asp Tyr Ser Asp Asn Val His Glu Val Arg Ile Ala Ala Ala Leu 
        115                 120                 125             


Trp Trp Tyr Phe Val Ser Lys Gly Val Glu Tyr Leu Asp Thr Val Phe 
    130                 135                 140                 


Phe Ile Leu Arg Lys Lys Asn Asn Gln Val Ser Phe Leu His Val Tyr 
145                 150                 155                 160 


His His Cys Thr Met Phe Thr Leu Trp Trp Ile Gly Ile Lys Trp Val 
                165                 170                 175     


Ala Gly Gly Gln Ala Phe Phe Gly Ala Gln Met Asn Ser Leu Ile His 
            180                 185                 190         


Val Ile Met Tyr Ser Tyr Tyr Gly Leu Ser Ala Phe Gly Pro Trp Ile 
        195                 200                 205             


Gln Lys Tyr Leu Trp Trp Lys Arg Tyr Leu Thr Met Leu Gln Leu Ile 
    210                 215                 220                 


Gln Phe His Val Thr Ile Gly His Thr Ala Leu Ser Leu Tyr Thr Asp 
225                 230                 235                 240 


Cys Pro Phe Pro Lys Trp Met His Trp Ala Leu Ile Val Tyr Ser Ile 
                245                 250                 255     


Ser Phe Ile Leu Leu Phe Leu Asn Phe Tyr Val Arg Thr Tyr Asn Met 
            260                 265                 270         


Pro Lys Lys Ser Gln Thr Gly Lys Pro Ala Val Asn Gly Ile Ser Ala 
        275                 280                 285             


Asn Gly Val Ser Lys Ser Glu Lys Gln Leu Val Met Glu Asn Gly Lys 
    290                 295                 300                 


Lys Gln Lys Thr Gly Lys Ala Lys Gly Glu 
305                 310                 


<210>  11
<211>  945
<212>  DNA
<213>  Gallus gallus

<400>  11
atgggtgccg ccgccgccga gcccccccgc gccgcgggcc tggtgtccag cgtgctgaac     60

gacaccctcg agttctaccg ctggacctgg agcatccgag acaaacgtgt cgatgattgg    120

cccttgatgc agtctccatt tccaacactg actataagca ctatttatct cctcactgtt    180

tggctgggcc ccaaatggat gaagacaaga gagcccttcc agttacgttt cctgttggtt    240

gtttacaact ttggaatggt tctactcaac ttcttcattt tcaaagagct gtttttatca    300

tcaagagctc gagggtacag ctatgtctgc cagactgtgg attattcaga taatgtttat    360

gaagttagga tagctgctgc tttatggtgg tattatgtct ccaaaggaat tgaataccta    420

gatacagtct tcttcatcct gaggaagaag ttcaaccaaa ttagttttct tcatgtctat    480

caccatttca ccatgttcac tttgtggtgg attggtatta agtgggttgc aggtggacaa    540

gctttttttg gagctcagat gaatgcattt attcatgtta ttatgtacat gtattacgga    600

ttagctgcct gtggccctaa agttcagaag tatctgtggt ggaaacgata cttgactata    660

ttgcaactgg tgcagttcca tgtgactatt ggccacacag ccttgtctat ttatatcgat    720

tgtcctttcc ctaaatggat gcactggggt gtaattttct atgctatcac cttcattttc    780

ttgtttggta acttctacta tcggacatat aagctgccca aggaacctgt aaagaatggc    840

aaaatagcaa atggtgctgt tgcaaacgga gtaagcaaac cagaaaataa tccagtggtg    900

gaaaatggaa aaaagcagaa aaagggaaaa gcaaaaggag agtaa                    945


<210>  12
<211>  313
<212>  PRT
<213>  Gallus gallus

<400>  12

Met Gly Ala Ala Ala Ala Glu Pro Pro Arg Ala Ala Gly Leu Val Ser 
1               5                   10                  15      


Ser Val Leu Asn Asp Thr Leu Glu Phe Tyr Arg Trp Thr Trp Ser Ile 
            20                  25                  30          


Arg Asp Lys Arg Val Asp Asp Trp Pro Leu Met Gln Ser Pro Phe Pro 
        35                  40                  45              


Thr Leu Thr Ile Ser Thr Ile Tyr Leu Leu Thr Val Trp Leu Gly Pro 
    50                  55                  60                  


Lys Trp Met Lys Thr Arg Glu Pro Phe Gln Leu Arg Phe Leu Leu Val 
65                  70                  75                  80  


Val Tyr Asn Phe Gly Met Val Leu Leu Asn Phe Phe Ile Phe Lys Glu 
                85                  90                  95      


Leu Phe Leu Ser Ser Arg Arg Gly Tyr Ser Tyr Val Cys Gln Thr Val 
            100                 105                 110         


Asp Tyr Ser Asp Asn Val Tyr Glu Val Arg Ile Ala Ala Ala Leu Trp 
        115                 120                 125             


Trp Tyr Tyr Val Ser Lys Gly Ile Glu Tyr Leu Asp Thr Val Phe Phe 
    130                 135                 140                 


Ile Leu Arg Lys Lys Phe Asn Gln Ile Ser Phe Leu His Val Tyr His 
145                 150                 155                 160 


His Phe Thr Met Phe Thr Leu Trp Trp Ile Gly Ile Lys Trp Val Ala 
                165                 170                 175     


Gly Gly Gln Ala Phe Phe Gly Ala Gln Met Asn Ala Phe Ile His Val 
            180                 185                 190         


Ile Met Tyr Met Tyr Tyr Gly Leu Ala Ala Cys Gly Pro Lys Val Gln 
        195                 200                 205             


Lys Tyr Leu Trp Trp Lys Arg Tyr Leu Thr Ile Leu Gln Leu Val Gln 
    210                 215                 220                 


Phe His Val Thr Ile Gly His Thr Ala Leu Ser Ile Tyr Ile Asp Cys 
225                 230                 235                 240 


Pro Phe Pro Lys Trp Met His Trp Gly Val Ile Phe Tyr Ala Ile Thr 
                245                 250                 255     


Phe Ile Phe Leu Phe Gly Asn Phe Tyr Tyr Arg Thr Tyr Lys Leu Pro 
            260                 265                 270         


Lys Glu Pro Val Lys Asn Gly Lys Ile Ala Asn Gly Ala Val Ala Asn 
        275                 280                 285             


Gly Val Ser Lys Pro Glu Asn Asn Pro Val Val Glu Asn Gly Lys Lys 
    290                 295                 300                 


Gln Lys Lys Gly Lys Ala Lys Gly Glu 
305                 310             


<210>  13
<211>  912
<212>  DNA
<213>  Danio rerio

<400>  13
atggagacgg tcgttcacct gatgaatgac tctgtagagt tttacaaatg gagccttacc     60

atagcagaca agcgtgtgga gaaatggccg atgatgtcat ctcctctgcc cactctgggg    120

atcagtgttt tgtacctgct cttcctttgg gccggccctc tttacatgca gaaccgcgag    180

cctttccagc tcaggaaaac actcattgtg tacaacttca gcatggtgct gcttaacttc    240

tacatctgca aagagctgct cctgggctcc agagcagccg gatacagcta cctctgccag    300

cctgtcaact actccaatga tgttaatgaa gtcaggatag catctgctct gtggtggtat    360

tacatctcca agggagtgga gtttctggac acggtcttct tcatcatgag gaagaagttt    420

aatcaggtca gcttcctgca cgtctatcac cactgcacaa tgttcatcct gtggtggatc    480

ggcatcaagt gggttcctgg tggacagtct ttctttggcg caacgattaa ctcaggcatt    540

catgtgctga tgtacggcta ctacggcctg gcagcgtttg gcccgaagat ccagaagtac    600

ctgtggtgga agaaatacct cactattatt cagatgatcc agttccacgt caccattggc    660

catgctgctc actctctcta cacgggctgt ccattcccag catggatgca gtgggctttg    720

attggctatg ccgttacatt catcatcctg ttcgccaatt tttactacca gacctaccgt    780

cgccagccac gtctcaagac agccaaatcc gcagttaacg gcgtctccat gtcaaccaac    840

ggcaccagca agacagccga ggtcacggaa aatggaaaga aacagaagaa aggaaaagga    900

aagcacgatt aa                                                        912


<210>  14
<211>  303
<212>  PRT
<213>  Danio rerio

<400>  14

Met Glu Thr Val Val His Leu Met Asn Asp Ser Val Glu Phe Tyr Lys 
1               5                   10                  15      


Trp Ser Leu Thr Ile Ala Asp Lys Arg Val Glu Lys Trp Pro Met Met 
            20                  25                  30          


Ser Ser Pro Leu Pro Thr Leu Gly Ile Ser Val Leu Tyr Leu Leu Phe 
        35                  40                  45              


Leu Trp Ala Gly Pro Leu Tyr Met Gln Asn Arg Glu Pro Phe Gln Leu 
    50                  55                  60                  


Arg Lys Thr Leu Ile Val Tyr Asn Phe Ser Met Val Leu Leu Asn Phe 
65                  70                  75                  80  


Tyr Ile Cys Lys Glu Leu Leu Leu Gly Ser Arg Ala Ala Gly Tyr Ser 
                85                  90                  95      


Tyr Leu Cys Gln Pro Val Asn Tyr Ser Asn Asp Val Asn Glu Val Arg 
            100                 105                 110         


Ile Ala Ser Ala Leu Trp Trp Tyr Tyr Ile Ser Lys Gly Val Glu Phe 
        115                 120                 125             


Leu Asp Thr Val Phe Phe Ile Met Arg Lys Lys Phe Asn Gln Val Ser 
    130                 135                 140                 


Phe Leu His Val Tyr His His Cys Thr Met Phe Ile Leu Trp Trp Ile 
145                 150                 155                 160 


Gly Ile Lys Trp Val Pro Gly Gly Gln Ser Phe Phe Gly Ala Thr Ile 
                165                 170                 175     


Asn Ser Gly Ile His Val Leu Met Tyr Gly Tyr Tyr Gly Leu Ala Ala 
            180                 185                 190         


Phe Gly Pro Lys Ile Gln Lys Tyr Leu Trp Trp Lys Lys Tyr Leu Thr 
        195                 200                 205             


Ile Ile Gln Met Ile Gln Phe His Val Thr Ile Gly His Ala Ala His 
    210                 215                 220                 


Ser Leu Tyr Thr Gly Cys Pro Phe Pro Ala Trp Met Gln Trp Ala Leu 
225                 230                 235                 240 


Ile Gly Tyr Ala Val Thr Phe Ile Ile Leu Phe Ala Asn Phe Tyr Tyr 
                245                 250                 255     


Gln Thr Tyr Arg Arg Gln Pro Arg Leu Lys Thr Ala Lys Ser Ala Val 
            260                 265                 270         


Asn Gly Val Ser Met Ser Thr Asn Gly Thr Ser Lys Thr Ala Glu Val 
        275                 280                 285             


Thr Glu Asn Gly Lys Lys Gln Lys Lys Gly Lys Gly Lys His Asp 
    290                 295                 300             


<210>  15
<211>  660
<212>  DNA
<213>  Xenopus

<400>  15
atgaagtcag ggtggcctca gctctctggt ggtactatgt ttcaaaaggg gtggaatatt     60

ttgacacagt atttttcata cttagaaaaa aaattcaacc aaattagttt tctgcatgta    120

tatcaccact gcacaatgtt cacactctgg tggatcggaa tcaaatgggt tgccggagga    180

caatcatttt ttggagcgca catgaatgca ctgatccatg ttgtgatgta cttatattat    240

gggttggctg cctgtggacc acatctacag aagtatttat ggtggaaacg atatctgaca    300

atattgcagc tggttcaatt ccatgtgaca atcggacata cagctttatc actgtacatt    360

gattgtccat ttcccaagtg gatgcattgg gctctgattg tgtatgctat cacttttatt    420

attcttttcg ttaacttcta ctaccggaca tacaatgctc ccaaagcacc agctaaaagt    480

gggaaatcac tcataaatgg aaagacctct gttaatggca agtcctctgt gaatggaaaa    540

tgccaaatta atggaaaatt aatgaatgga gcagttaatg gagctgtaag caagcaagat    600

aataaagttg gacaagaaaa tgggcgaaaa aggagaaaag gaagagccaa gcgagaataa    660


<210>  16
<211>  219
<212>  PRT
<213>  Xenopus

<400>  16

Met Lys Ser Gly Trp Pro Gln Leu Ser Gly Gly Thr Met Phe Gln Lys 
1               5                   10                  15      


Gly Trp Asn Ile Leu Thr Gln Tyr Phe Ser Tyr Leu Glu Lys Lys Phe 
            20                  25                  30          


Asn Gln Ile Ser Phe Leu His Val Tyr His His Cys Thr Met Phe Thr 
        35                  40                  45              


Leu Trp Trp Ile Gly Ile Lys Trp Val Ala Gly Gly Gln Ser Phe Phe 
    50                  55                  60                  


Gly Ala His Met Asn Ala Leu Ile His Val Val Met Tyr Leu Tyr Tyr 
65                  70                  75                  80  


Gly Leu Ala Ala Cys Gly Pro His Leu Gln Lys Tyr Leu Trp Trp Lys 
                85                  90                  95      


Arg Tyr Leu Thr Ile Leu Gln Leu Val Gln Phe His Val Thr Ile Gly 
            100                 105                 110         


His Thr Ala Leu Ser Leu Tyr Ile Asp Cys Pro Phe Pro Lys Trp Met 
        115                 120                 125             


His Trp Ala Leu Ile Val Tyr Ala Ile Thr Phe Ile Ile Leu Phe Val 
    130                 135                 140                 


Asn Phe Tyr Tyr Arg Thr Tyr Asn Ala Pro Lys Ala Pro Ala Lys Ser 
145                 150                 155                 160 


Gly Lys Ser Leu Ile Asn Gly Lys Thr Ser Val Asn Gly Lys Ser Ser 
                165                 170                 175     


Val Asn Gly Lys Cys Gln Ile Asn Gly Lys Leu Met Asn Gly Ala Val 
            180                 185                 190         


Asn Gly Ala Val Ser Lys Gln Asp Asn Lys Val Gly Gln Glu Asn Gly 
        195                 200                 205             


Arg Lys Arg Arg Lys Gly Arg Ala Lys Arg Glu 
    210                 215                 


<210>  17
<211>  1038
<212>  DNA
<213>  Yeast

<400>  17
atgaacacta ccacatctac tgttatagca gcagttgccg accagttcca gtctttgaac     60

tcttcttctt catgtttctt gaaggttcat gttccttcca ttgagaaccc attcggtatt    120

gaattatggc caattttctc caaagtgttt gaatacttta gtggctatcc agctgagcaa    180

ttcgagttta ttcacaataa gactttcttg gctaacgggt atcatgctgt tagtattatt    240

atcgtttatt acattattat ctttggtggc caagctatct tacgcgcctt gaacgcctct    300

ccattaaagt ttaaattgct tttcgagata cacaacttgt ttttgacttc tatttctcta    360

gttttatggt tgctgatgtt agaacagttg gttcctatgg tttatcacaa cggtctattc    420

tggtctatct gctctaagga agccttcgca ccaaaattag ttactcttta ctatttgaac    480

tatttgacca aattcgtaga attgattgac actgtgtttt tagttttgag aagaaagaag    540

ttattgtttt tgcacactta ccatcacggt gccaccgctt tgttgtgcta cactcaatta    600

attggtcgta cttctgttga atgggtagtt atcctactaa acttgggtgt tcacgttatc    660

atgtactggt actacttctt gagttcatgt ggtattagag tttggtggaa gcaatgggtc    720

actagattcc aaattattca atttttgatt gacttggtat ttgtttactt tgctacctat    780

acattctatg ctcacaaata cttggacggt attttaccaa acaagggtac ttgttatggt    840

actcaggctg ctgctgctta tgggtatttg attctaacat cttatttgct tttgtttatt    900

tccttctaca tccaatctta caagaaaggt ggtaaaaaga cagtcaagaa ggaatctgaa    960

gtttccggct ccgttgcatc cggttcttct actggtgtca agacctctaa caccaaggtc   1020

tcttccagga aagcttaa                                                 1038


<210>  18
<211>  345
<212>  PRT
<213>  Yeast

<400>  18

Met Asn Thr Thr Thr Ser Thr Val Ile Ala Ala Val Ala Asp Gln Phe 
1               5                   10                  15      


Gln Ser Leu Asn Ser Ser Ser Ser Cys Phe Leu Lys Val His Val Pro 
            20                  25                  30          


Ser Ile Glu Asn Pro Phe Gly Ile Glu Leu Trp Pro Ile Phe Ser Lys 
        35                  40                  45              


Val Phe Glu Tyr Phe Ser Gly Tyr Pro Ala Glu Gln Phe Glu Phe Ile 
    50                  55                  60                  


His Asn Lys Thr Phe Leu Ala Asn Gly Tyr His Ala Val Ser Ile Ile 
65                  70                  75                  80  


Ile Val Tyr Tyr Ile Ile Ile Phe Gly Gly Gln Ala Ile Leu Arg Ala 
                85                  90                  95      


Leu Asn Ala Ser Pro Leu Lys Phe Lys Leu Leu Phe Glu Ile His Asn 
            100                 105                 110         


Leu Phe Leu Thr Ser Ile Ser Leu Val Leu Trp Leu Leu Met Leu Glu 
        115                 120                 125             


Gln Leu Val Pro Met Val Tyr His Asn Gly Leu Phe Trp Ser Ile Cys 
    130                 135                 140                 


Ser Lys Glu Ala Phe Ala Pro Lys Leu Val Thr Leu Tyr Tyr Leu Asn 
145                 150                 155                 160 


Tyr Leu Thr Lys Phe Val Glu Leu Ile Asp Thr Val Phe Leu Val Leu 
                165                 170                 175     


Arg Arg Lys Lys Leu Leu Phe Leu His Thr Tyr His His Gly Ala Thr 
            180                 185                 190         


Ala Leu Leu Cys Tyr Thr Gln Leu Ile Gly Arg Thr Ser Val Glu Trp 
        195                 200                 205             


Val Val Ile Leu Leu Asn Leu Gly Val His Val Ile Met Tyr Trp Tyr 
    210                 215                 220                 


Tyr Phe Leu Ser Ser Cys Gly Ile Arg Val Trp Trp Lys Gln Trp Val 
225                 230                 235                 240 


Thr Arg Phe Gln Ile Ile Gln Phe Leu Ile Asp Leu Val Phe Val Tyr 
                245                 250                 255     


Phe Ala Thr Tyr Thr Phe Tyr Ala His Lys Tyr Leu Asp Gly Ile Leu 
            260                 265                 270         


Pro Asn Lys Gly Thr Cys Tyr Gly Thr Gln Ala Ala Ala Ala Tyr Gly 
        275                 280                 285             


Tyr Leu Ile Leu Thr Ser Tyr Leu Leu Leu Phe Ile Ser Phe Tyr Ile 
    290                 295                 300                 


Gln Ser Tyr Lys Lys Gly Gly Lys Lys Thr Val Lys Lys Glu Ser Glu 
305                 310                 315                 320 


Val Ser Gly Ser Val Ala Ser Gly Ser Ser Thr Gly Val Lys Thr Ser 
                325                 330                 335     


Asn Thr Lys Val Ser Ser Arg Lys Ala 
            340                 345 


<210>  19
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Completely synthesized.


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is gly, ala, val, leu, ile, met, phe, pro, ser,
       thr, cys, asn, gln, tyr, trp, asp, glu, his, lys, arg.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is gly, ala, val, leu, ile, met, phe, pro, ser,
       thr, cys, asn, gln, tyr, trp, asp, glu, his, lys, arg.

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is gly, ala, val, leu, ile, met, phe, pro, ser,
       thr, cys, asn, gln, tyr, trp, asp, glu, his, lys, arg.

<400>  19

Lys Xaa Lys Xaa Xaa 
1               5   


<210>  20
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Completely synthesized.


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is gly, ala, val, leu, ile, met, phe, pro, ser,
       thr, cys, asn, gln, tyr, trp, asp, glu, his, lys, arg.

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is gly, ala, val, leu, ile, met, phe, pro, ser,
       thr, cys, asn, gln, tyr, trp, asp, glu, his, lys, arg.

<400>  20

His Xaa Xaa His His 
1               5   


