                         SEQUENCE LISTING

<110>  Abbott Laboratories
 
<120>  IMPROVED MAMMALIAN EXPRESSION VECTORS AND USES THEREOF

<130>  BBI-316PC

<140>  Not yet assigned
<141>  Concurrently herewith

<150>  61/
<151>  2008

<150>  61/
<151>  2008-

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  6381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pHybC-empty             


<220>
<221>  misc_feature
<222>  (1143)..(1242)
<223>  n is a, c, g, or t

<400>  1
ttgacattga ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag       60

cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc      120

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      180

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca      240

tcaagtgtat catatgccaa gtccgccccc tattgacgtc aatgacggta aatggcccgc      300

ctggcattat gcccagtaca tgaccttacg ggactttcct acttggcagt acatctacgt      360

attagtcatc gctattacca tggtgatgcg gttttggcag tacaccaatg ggcgtggata      420

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt      480

ttggcaccaa aatcaacggg actttccaaa atgtcgtaat aaccccgccc cgttgacgca      540

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt tagtgaaccg      600

tcagatcctc actctcttcc gcatcgctgt ctgcgagggc cagctgttgg gctcgcggtt      660

gaggacaaac tcttcgcggt ctttccagta ctcttggatc ggaaacccgt cggcctccga      720

acggtactcc gccaccgagg gacctgagcg agtccgcatc gaccggatcg gaaaacctct      780

cgagaaaggc gtctaaccag tcacagtcgc aaggtaggct gagcaccgtg gcgggcggca      840

gcgggtggcg gtcggggttg tttctggcgg aggtgctgct gatgatgtaa ttaaagtagg      900

cggtcttgag acggcggatg gtcgaggtga ggtgtggcag gcttgagatc cagctgttgg      960

ggtgagtact ccctctcaaa agcgggcatt acttctgcgc taagattgtc agtttccaaa     1020

aacgaggagg atttgatatt cacctggccc gatctggcca tacacttgag tgacaatgac     1080

atccactttg cctttctctc cacaggtgtc cactcccagg tccaagtttg ggcgccacca     1140

tgnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1200

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntgagcggc cgctcgaggc     1260

cggcaaggcc ggatcccccg acctcgacct ctggctaata aaggaaattt attttcattg     1320

caatagtgtg ttggaatttt ttgtgtctct cactcggaag gacatatggg agggcaaatc     1380

atttggtcga gatccctcgg agatctctag ctagaggatc gatccccgcc ccggacgaac     1440

taaacctgac tacgacatct ctgccccttc ttcgcggggc agtgcatgta atcccttcag     1500

ttggttggta caacttgcca actgggccct gttccacatg tgacacgggg ggggaccaaa     1560

cacaaagggg ttctctgact gtagttgaca tccttataaa tggatgtgca catttgccaa     1620

cactgagtgg ctttcatcct ggagcagact ttgcagtctg tggactgcaa cacaacattg     1680

cctttatgtg taactcttgg ctgaagctct tacaccaatg ctgggggaca tgtacctccc     1740

aggggcccag gaagactacg ggaggctaca ccaacgtcaa tcagaggggc ctgtgtagct     1800

accgataagc ggaccctcaa gagggcatta gcaatagtgt ttataaggcc cccttgttaa     1860

ccctaaacgg gtagcatatg cttcccgggt agtagtatat actatccaga ctaaccctaa     1920

ttcaatagca tatgttaccc aacgggaagc atatgctatc gaattagggt tagtaaaagg     1980

gtcctaagga acagcgatat ctcccacccc atgagctgtc acggttttat ttacatgggg     2040

tcaggattcc acgagggtag tgaaccattt tagtcacaag ggcagtggct gaagatcaag     2100

gagcgggcag tgaactctcc tgaatcttcg cctgcttctt cattctcctt cgtttagcta     2160

atagaataac tgctgagttg tgaacagtaa ggtgtatgtg aggtgctcga aaacaaggtt     2220

tcaggtgacg cccccagaat aaaatttgga cggggggttc agtggtggca ttgtgctatg     2280

acaccaatat aaccctcaca aaccccttgg gcaataaata ctagtgtagg aatgaaacat     2340

tctgaatatc tttaacaata gaaatccatg gggtggggac aagccgtaaa gactggatgt     2400

ccatctcaca cgaatttatg gctatgggca acacataatc ctagtgcaat atgatactgg     2460

ggttattaag atgtgtccca ggcagggacc aagacaggtg aaccatgttg ttacactcta     2520

tttgtaacaa ggggaaagag agtggacgcc gacagcagcg gactccactg gttgtctcta     2580

acacccccga aaattaaacg gggctccacg ccaatggggc ccataaacaa agacaagtgg     2640

ccactctttt ttttgaaatt gtggagtggg ggcacgcgtc agcccccaca cgccgccctg     2700

cggttttgga ctgtaaaata agggtgtaat aacttggctg attgtaaccc cgctaaccac     2760

tgcggtcaaa ccacttgccc acaaaaccac taatggcacc ccggggaata cctgcataag     2820

taggtgggcg ggccaagata ggggcgcgat tgctgcgatc tggaggacaa attacacaca     2880

cttgcgcctg agcgccaagc acagggttgt tggtcctcat attcacgagg tcgctgagag     2940

cacggtgggc taatgttgcc atgggtagca tatactaccc aaatatctgg atagcatatg     3000

ctatcctaat ctatatctgg gtagcatagg ctatcctaat ctatatctgg gtagcatatg     3060

ctatcctaat ctatatctgg gtagtatatg ctatcctaat ttatatctgg gtagcatagg     3120

ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagtatatg     3180

ctatcctaat ctgtatccgg gtagcatatg ctatcctaat agagattagg gtagtatatg     3240

ctatcctaat ttatatctgg gtagcatata ctacccaaat atctggatag catatgctat     3300

cctaatctat atctgggtag catatgctat cctaatctat atctgggtag cataggctat     3360

cctaatctat atctgggtag catatgctat cctaatctat atctgggtag tatatgctat     3420

cctaatttat atctgggtag cataggctat cctaatctat atctgggtag catatgctat     3480

cctaatctat atctgggtag tatatgctat cctaatctgt atccgggtag catatgctat     3540

cctcatgata agctgtcaaa catgagaatt ttcttgaaga cgaaagggcc tcgtgatacg     3600

cctattttta taggttaatg tcatgataat aatggtttct tagacgtcag gtggcacttt     3660

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta     3720

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat     3780

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt     3840

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg     3900

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga     3960

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg     4020

tgttgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt     4080

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg     4140

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg     4200

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     4260

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     4320

tgcagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc     4380

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     4440

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg     4500

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac     4560

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     4620

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt     4680

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac     4740

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     4800

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     4860

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     4920

aactggcttc agcagagcgc agataccaaa tactgttctt ctagtgtagc cgtagttagg     4980

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     5040

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     5100

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     5160

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct     5220

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     5280

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     5340

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     5400

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt     5460

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     5520

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga     5580

gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca     5640

cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg tgagttagct     5700

cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt tgtgtggaat     5760

tgtgagcgga taacaatttc acacaggaaa cagctatgac catgattacg ccaagctcta     5820

gctagaggtc gagtccctcc ccagcaggca gaagtatgca aagcatgcat ctcaattagt     5880

cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg cccagttccg     5940

cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc gaggccgcct     6000

cggcctctga gctattccag aagtagtgag gaggcttttt tggaggccta ggcttttgca     6060

aaaagctttg caaagatgga taaagtttta aacagagagg aatctttgca gctaatggac     6120

cttctaggtc ttgaaaggag ctcgaccaat tctcatgttt gacagcttat catcgcagat     6180

ccgggcaacg ttgttgccat tgctgcaggc gcagaactgg taggtatgga agatctatac     6240

attgaatcaa tattggcaat tagccatatt agtcattggt tatatagcat aaatcaatat     6300

tggctattgg ccattgcata cgttgtatct atatcataat atgtacattt atattggctc     6360

atgtccaata tgaccgccat g                                               6381


<210>  2
<211>  6212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pHybE-empty         


<220>
<221>  misc_feature
<222>  (1320)..(1391)
<223>  n is a, c, g, or t

<400>  2
agctttgcaa agatggataa agttttaaac agagaggaat ctttgcagct aatggacctt       60

ctaggtcttg aaaggagtgg gaattggctc cggtgcccgt cagtgggcag agcgcacatc      120

gcccacagtc cccgagaagt tggggggagg ggtcggcaat tgaaccggtg cctagagaag      180

gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg      240

tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt      300

tgccgccaga acacaggtaa gtgccgtgtg tggttcccgc gggcctggcc tctttacggg      360

ttatggccct tgcgtgcctt gaattacttc cacctggctg cagtacgtga ttcttgatcc      420

cgagcttcgg gttggaagtg ggtgggagag ttcgaggcct tgcgcttaag gagccccttc      480

gcctcgtgct tgagttgagg cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg      540

gcaccttcgc gcctgtctcg ctgctttcga taagtctcta gccatttaaa atttttgatg      600

acctgctgcg acgctttttt tctggcaaga tagtcttgta aatgcgggcc aagatctgca      660

cactggtatt tcggtttttg gggccgcggg cggcgacggg gcccgtgcgt cccagcgcac      720

atgttcggcg aggcggggcc tgcgagcgcg gccaccgaga atcggacggg ggtagtctca      780

agctggccgg cctgctctgg tgcctggcct cgcgccgccg tgtatcgccc cgccctgggc      840

ggcaaggctg gcccggtcgg caccagttgc gtgagcggaa agatggccgc ttcccggccc      900

tgctgcaggg agctcaaaat ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc      960

cacacaaagg aaaagggcct ttccgtcctc agccgtcgct tcatgtgact ccacggagta     1020

ccgggcgccg tccaggcacc tcgattagtt ctcgagcttt tggagtacgt cgtctttagg     1080

ttggggggag gggttttatg cgatggagtt tccccacact gagtgggtgg agactgaagt     1140

taggccagct tggcacttga tgtaattctc cttggaattt gccctttttg agtttggatc     1200

ttggttcatt ctcaagcctc agacagtggt tcaaagtttt tttcttccat ttcaggtgtc     1260

gtgaggaatt ctctagagat ccctcgacct cgagatccat tgtgcccggg cgcaccatgn     1320

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1380

nnnnnnnnnn ntgagcggcc gctcgaggcc ggcaaggccg gatcccccga cctcgacctc     1440

tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc     1500

actcggaagg acatatggga gggcaaatca tttggtcgag atccctcgga gatctctagc     1560

tagaggatcg atccccgccc cggacgaact aaacctgact acgacatctc tgccccttct     1620

tcgcggggca gtgcatgtaa tcccttcagt tggttggtac aacttgccaa ctgggccctg     1680

ttccacatgt gacacggggg gggaccaaac acaaaggggt tctctgactg tagttgacat     1740

ccttataaat ggatgtgcac atttgccaac actgagtggc tttcatcctg gagcagactt     1800

tgcagtctgt ggactgcaac acaacattgc ctttatgtgt aactcttggc tgaagctctt     1860

acaccaatgc tgggggacat gtacctccca ggggcccagg aagactacgg gaggctacac     1920

caacgtcaat cagaggggcc tgtgtagcta ccgataagcg gaccctcaag agggcattag     1980

caatagtgtt tataaggccc ccttgttaac cctaaacggg tagcatatgc ttcccgggta     2040

gtagtatata ctatccagac taaccctaat tcaatagcat atgttaccca acgggaagca     2100

tatgctatcg aattagggtt agtaaaaggg tcctaaggaa cagcgatatc tcccacccca     2160

tgagctgtca cggttttatt tacatggggt caggattcca cgagggtagt gaaccatttt     2220

agtcacaagg gcagtggctg aagatcaagg agcgggcagt gaactctcct gaatcttcgc     2280

ctgcttcttc attctccttc gtttagctaa tagaataact gctgagttgt gaacagtaag     2340

gtgtatgtga ggtgctcgaa aacaaggttt caggtgacgc ccccagaata aaatttggac     2400

ggggggttca gtggtggcat tgtgctatga caccaatata accctcacaa accccttggg     2460

caataaatac tagtgtagga atgaaacatt ctgaatatct ttaacaatag aaatccatgg     2520

ggtggggaca agccgtaaag actggatgtc catctcacac gaatttatgg ctatgggcaa     2580

cacataatcc tagtgcaata tgatactggg gttattaaga tgtgtcccag gcagggacca     2640

agacaggtga accatgttgt tacactctat ttgtaacaag gggaaagaga gtggacgccg     2700

acagcagcgg actccactgg ttgtctctaa cacccccgaa aattaaacgg ggctccacgc     2760

caatggggcc cataaacaaa gacaagtggc cactcttttt tttgaaattg tggagtgggg     2820

gcacgcgtca gcccccacac gccgccctgc ggttttggac tgtaaaataa gggtgtaata     2880

acttggctga ttgtaacccc gctaaccact gcggtcaaac cacttgccca caaaaccact     2940

aatggcaccc cggggaatac ctgcataagt aggtgggcgg gccaagatag gggcgcgatt     3000

gctgcgatct ggaggacaaa ttacacacac ttgcgcctga gcgccaagca cagggttgtt     3060

ggtcctcata ttcacgaggt cgctgagagc acggtgggct aatgttgcca tgggtagcat     3120

atactaccca aatatctgga tagcatatgc tatcctaatc tatatctggg tagcataggc     3180

tatcctaatc tatatctggg tagcatatgc tatcctaatc tatatctggg tagtatatgc     3240

tatcctaatt tatatctggg tagcataggc tatcctaatc tatatctggg tagcatatgc     3300

tatcctaatc tatatctggg tagtatatgc tatcctaatc tgtatccggg tagcatatgc     3360

tatcctaata gagattaggg tagtatatgc tatcctaatt tatatctggg tagcatatac     3420

tacccaaata tctggatagc atatgctatc ctaatctata tctgggtagc atatgctatc     3480

ctaatctata tctgggtagc ataggctatc ctaatctata tctgggtagc atatgctatc     3540

ctaatctata tctgggtagt atatgctatc ctaatttata tctgggtagc ataggctatc     3600

ctaatctata tctgggtagc atatgctatc ctaatctata tctgggtagt atatgctatc     3660

ctaatctgta tccgggtagc atatgctatc ctcatgataa gctgtcaaac atgagaattt     3720

tcttgaagac gaaagggcct cgtgatacgc ctatttttat aggttaatgt catgataata     3780

atggtttctt agacgtcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt     3840

ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg     3900

cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt     3960

cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta     4020

aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc     4080

ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa     4140

gttctgctat gtggcgcggt attatcccgt gttgacgccg ggcaagagca actcggtcgc     4200

cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt     4260

acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact     4320

gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac     4380

aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata     4440

ccaaacgacg agcgtgacac cacgatgcct gcagcaatgg caacaacgtt gcgcaaacta     4500

ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg     4560

gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat     4620

aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt     4680

aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga     4740

aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa     4800

gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag     4860

gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac     4920

tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc     4980

gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat     5040

caagagctac caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat     5100

actgttcttc tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct     5160

acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt     5220

cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg     5280

gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta     5340

cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg     5400

gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg     5460

tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc     5520

tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg     5580

gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat     5640

aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc     5700

agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc tctccccgcg     5760

cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa agcgggcagt     5820

gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc tttacacttt     5880

atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca cacaggaaac     5940

agctatgacc atgattacgc caagctctag ctagaggtcg agtccctccc cagcaggcag     6000

aagtatgcaa agcatgcatc tcaattagtc agcaaccata gtcccgcccc taactccgcc     6060

catcccgccc ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt     6120

ttttatttat gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg     6180

aggctttttt ggaggcctag gcttttgcaa aa                                   6212


<210>  3
<211>  7498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP180 ; pHybE-mCk V1

<400>  3
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgagc atttaaatgc ccgggcgcac catggacatg cgcgtgcccg     1260

cccagctgct gggcctgctg ctgctgtggt tccccggctc gcgatgcgca tggtatgccg     1320

aaagggatgc tgaaattgag aacgaaaagc tgcgccggga ggttgaagaa ctgcggcagg     1380

ccagcgaggc agatctccag ccaggaacta ttgagtacga acgccatcga cttacgcgtg     1440

cgcaggccga cgcacaggaa ctgaagaatg ccagagactc cgctgaagtg gtggaaaccg     1500

cattctgtac tttcgtgctg tcgcggatcg caggtgaaat tgccagtatt ctcgacgggc     1560

tccccctgtc ggtgcagcgg cgttttccgg aactggaaaa ccgacatgtt gatttcctga     1620

aacgggatat catcaaagcc atgaacaaag cagccgcgct ggatgaactg ataccggggt     1680

tgctgagtga atatatcgaa cagtcaggtt aacaggctgc ggcattttgt ccgcgccggg     1740

cttcgctcac tgttcaggcc ggagccacag accgccgttg aatgggcgga tgctaattac     1800

tatctcccga aagaatccgc ataccaggaa gggcgctggg aaacactgcc ctttcagcgg     1860

gccatcatga atgcgatggg cagcgactac atccgtgagg tgaatgtggt gaagtctgcc     1920

cgtgtcggtt attccaaaat gctgctgggt gtttatgcct actttataga gcataagcag     1980

cgcaacaccc ttatctggtt gccgacggat ggtgatgccg agaactttat gaaaacccac     2040

gttgagccga ctattcgtga tattccgtcg ctgctggcgc tggccccgtg gtatggcaaa     2100

aagcaccggg ataacacgct caccatgaag cgtttcacta atgggcgtgg cttctggtgc     2160

ctgggcggta aagcggcaaa aaactaccgt gaaaagtcgg tggatgtggc gggttatgat     2220

gaacttgctg cttttgatga tgatattgaa caggaaggct ctccgacgtt cctgggtgac     2280

aagcgctgat gctgcaccaa ctgtatccat cttcccacca tccagtgagc agttaacatc     2340

tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac cccaaagaca tcaatgtcaa     2400

gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg aacagttgga ctgatcagga     2460

cagcaaagac agcacctaca gcatgagcag caccctcacg ttgaccaagg acgagtatga     2520

acgacataac agctatacct gtgaggccac tcacaagaca tcaacttcac ccattgtcaa     2580

gagcttcaac aggaatgagt gttaagcggc cgctcgaggc cggcaaggcc ggatcccccg     2640

acctcgacct ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt     2700

ttgtgtctct cactcggaag gacatatggg agggcaaatc atttggtcga gatccctcgg     2760

agatctctag ctagaggatc gatccccgcc ccggacgaac taaacctgac tacgacatct     2820

ctgccccttc ttcgcggggc agtgcatgta atcccttcag ttggttggta caacttgcca     2880

actgggccct gttccacatg tgacacgggg ggggaccaaa cacaaagggg ttctctgact     2940

gtagttgaca tccttataaa tggatgtgca catttgccaa cactgagtgg ctttcatcct     3000

ggagcagact ttgcagtctg tggactgcaa cacaacattg cctttatgtg taactcttgg     3060

ctgaagctct tacaccaatg ctgggggaca tgtacctccc aggggcccag gaagactacg     3120

ggaggctaca ccaacgtcaa tcagaggggc ctgtgtagct accgataagc ggaccctcaa     3180

gagggcatta gcaatagtgt ttataaggcc cccttgttaa ccctaaacgg gtagcatatg     3240

cttcccgggt agtagtatat actatccaga ctaaccctaa ttcaatagca tatgttaccc     3300

aacgggaagc atatgctatc gaattagggt tagtaaaagg gtcctaagga acagcgatat     3360

ctcccacccc atgagctgtc acggttttat ttacatgggg tcaggattcc acgagggtag     3420

tgaaccattt tagtcacaag ggcagtggct gaagatcaag gagcgggcag tgaactctcc     3480

tgaatcttcg cctgcttctt cattctcctt cgtttagcta atagaataac tgctgagttg     3540

tgaacagtaa ggtgtatgtg aggtgctcga aaacaaggtt tcaggtgacg cccccagaat     3600

aaaatttgga cggggggttc agtggtggca ttgtgctatg acaccaatat aaccctcaca     3660

aaccccttgg gcaataaata ctagtgtagg aatgaaacat tctgaatatc tttaacaata     3720

gaaatccatg gggtggggac aagccgtaaa gactggatgt ccatctcaca cgaatttatg     3780

gctatgggca acacataatc ctagtgcaat atgatactgg ggttattaag atgtgtccca     3840

ggcagggacc aagacaggtg aaccatgttg ttacactcta tttgtaacaa ggggaaagag     3900

agtggacgcc gacagcagcg gactccactg gttgtctcta acacccccga aaattaaacg     3960

gggctccacg ccaatggggc ccataaacaa agacaagtgg ccactctttt ttttgaaatt     4020

gtggagtggg ggcacgcgtc agcccccaca cgccgccctg cggttttgga ctgtaaaata     4080

agggtgtaat aacttggctg attgtaaccc cgctaaccac tgcggtcaaa ccacttgccc     4140

acaaaaccac taatggcacc ccggggaata cctgcataag taggtgggcg ggccaagata     4200

ggggcgcgat tgctgcgatc tggaggacaa attacacaca cttgcgcctg agcgccaagc     4260

acagggttgt tggtcctcat attcacgagg tcgctgagag cacggtgggc taatgttgcc     4320

atgggtagca tatactaccc aaatatctgg atagcatatg ctatcctaat ctatatctgg     4380

gtagcatagg ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg     4440

gtagtatatg ctatcctaat ttatatctgg gtagcatagg ctatcctaat ctatatctgg     4500

gtagcatatg ctatcctaat ctatatctgg gtagtatatg ctatcctaat ctgtatccgg     4560

gtagcatatg ctatcctaat agagattagg gtagtatatg ctatcctaat ttatatctgg     4620

gtagcatata ctacccaaat atctggatag catatgctat cctaatctat atctgggtag     4680

catatgctat cctaatctat atctgggtag cataggctat cctaatctat atctgggtag     4740

catatgctat cctaatctat atctgggtag tatatgctat cctaatttat atctgggtag     4800

cataggctat cctaatctat atctgggtag catatgctat cctaatctat atctgggtag     4860

tatatgctat cctaatctgt atccgggtag catatgctat cctcatgata agctgtcaaa     4920

catgagaatt ttcttgaaga cgaaagggcc tcgtgatacg cctattttta taggttaatg     4980

tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa     5040

cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac     5100

cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg     5160

tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc     5220

tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg     5280

atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga     5340

gcacttttaa agttctgcta tgtggcgcgg tattatcccg tgttgacgcc gggcaagagc     5400

aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag     5460

aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga     5520

gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg     5580

cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga     5640

atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgcagcaatg gcaacaacgt     5700

tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact     5760

ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt     5820

ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg     5880

ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta     5940

tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac     6000

tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat ttttaattta     6060

aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt     6120

tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt     6180

tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt     6240

gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc     6300

agataccaaa tactgttctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg     6360

tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg     6420

ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt     6480

cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac     6540

tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg     6600

acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg     6660

gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat     6720

ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt     6780

tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg ttatcccctg     6840

attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc cgcagccgaa     6900

cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc     6960

ctctccccgc gcgttggccg attcattaat gcagctggca cgacaggttt cccgactgga     7020

aagcgggcag tgagcgcaac gcaattaatg tgagttagct cactcattag gcaccccagg     7080

ctttacactt tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc     7140

acacaggaaa cagctatgac catgattacg ccaagctcta gctagaggtc gagtccctcc     7200

ccagcaggca gaagtatgca aagcatgcat ctcaattagt cagcaaccat agtcccgccc     7260

ctaactccgc ccatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc     7320

tgactaattt tttttattta tgcagaggcc gaggccgcct cggcctctga gctattccag     7380

aagtagtgag gaggcttttt tggaggccta ggcttttgca aaaagctttg caaagatgga     7440

taaagtttta aacagagagg aatctttgca gctaatggac cttctaggtc ttgaaagg       7498


<210>  4
<211>  7498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP193 ; pHybE-mCk V2  

<400>  4
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgaga tccattgtgc ccgggcgcac catggacatg cgcgtgcccg     1260

cccagctgct gggcctgctg ctgctgtggt tccccggctc gcgatgcgca tggtatgccg     1320

aaagggatgc tgaaattgag aacgaaaagc tgcgccggga ggttgaagaa ctgcggcagg     1380

ccagcgaggc agatctccag ccaggaacta ttgagtacga acgccatcga cttacgcgtg     1440

cgcaggccga cgcacaggaa ctgaagaatg ccagagactc cgctgaagtg gtggaaaccg     1500

cattctgtac tttcgtgctg tcgcggatcg caggtgaaat tgccagtatt ctcgacgggc     1560

tccccctgtc ggtgcagcgg cgttttccgg aactggaaaa ccgacatgtt gatttcctga     1620

aacgggatat catcaaagcc atgaacaaag cagccgcgct ggatgaactg ataccggggt     1680

tgctgagtga atatatcgaa cagtcaggtt aacaggctgc ggcattttgt ccgcgccggg     1740

cttcgctcac tgttcaggcc ggagccacag accgccgttg aatgggcgga tgctaattac     1800

tatctcccga aagaatccgc ataccaggaa gggcgctggg aaacactgcc ctttcagcgg     1860

gccatcatga atgcgatggg cagcgactac atccgtgagg tgaatgtggt gaagtctgcc     1920

cgtgtcggtt attccaaaat gctgctgggt gtttatgcct actttataga gcataagcag     1980

cgcaacaccc ttatctggtt gccgacggat ggtgatgccg agaactttat gaaaacccac     2040

gttgagccga ctattcgtga tattccgtcg ctgctggcgc tggccccgtg gtatggcaaa     2100

aagcaccggg ataacacgct caccatgaag cgtttcacta atgggcgtgg cttctggtgc     2160

ctgggcggta aagcggcaaa aaactaccgt gaaaagtcgg tggatgtggc gggttatgat     2220

gaacttgctg cttttgatga tgatattgaa caggaaggct ctccgacgtt cctgggtgac     2280

aagcgctgat gctgcaccaa ctgtatccat cttcccacca tccagtgagc agttaacatc     2340

tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac cccaaagaca tcaatgtcaa     2400

gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg aacagttgga ctgatcagga     2460

cagcaaagac agcacctaca gcatgagcag caccctcacg ttgaccaagg acgagtatga     2520

acgacataac agctatacct gtgaggccac tcacaagaca tcaacttcac ccattgtcaa     2580

gagcttcaac aggaatgagt gttaagcggc cgctcgaggc cggcaaggcc ggatcccccg     2640

acctcgacct ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt     2700

ttgtgtctct cactcggaag gacatatggg agggcaaatc atttggtcga gatccctcgg     2760

agatctctag ctagaggatc gatccccgcc ccggacgaac taaacctgac tacgacatct     2820

ctgccccttc ttcgcggggc agtgcatgta atcccttcag ttggttggta caacttgcca     2880

actgggccct gttccacatg tgacacgggg ggggaccaaa cacaaagggg ttctctgact     2940

gtagttgaca tccttataaa tggatgtgca catttgccaa cactgagtgg ctttcatcct     3000

ggagcagact ttgcagtctg tggactgcaa cacaacattg cctttatgtg taactcttgg     3060

ctgaagctct tacaccaatg ctgggggaca tgtacctccc aggggcccag gaagactacg     3120

ggaggctaca ccaacgtcaa tcagaggggc ctgtgtagct accgataagc ggaccctcaa     3180

gagggcatta gcaatagtgt ttataaggcc cccttgttaa ccctaaacgg gtagcatatg     3240

cttcccgggt agtagtatat actatccaga ctaaccctaa ttcaatagca tatgttaccc     3300

aacgggaagc atatgctatc gaattagggt tagtaaaagg gtcctaagga acagcgatat     3360

ctcccacccc atgagctgtc acggttttat ttacatgggg tcaggattcc acgagggtag     3420

tgaaccattt tagtcacaag ggcagtggct gaagatcaag gagcgggcag tgaactctcc     3480

tgaatcttcg cctgcttctt cattctcctt cgtttagcta atagaataac tgctgagttg     3540

tgaacagtaa ggtgtatgtg aggtgctcga aaacaaggtt tcaggtgacg cccccagaat     3600

aaaatttgga cggggggttc agtggtggca ttgtgctatg acaccaatat aaccctcaca     3660

aaccccttgg gcaataaata ctagtgtagg aatgaaacat tctgaatatc tttaacaata     3720

gaaatccatg gggtggggac aagccgtaaa gactggatgt ccatctcaca cgaatttatg     3780

gctatgggca acacataatc ctagtgcaat atgatactgg ggttattaag atgtgtccca     3840

ggcagggacc aagacaggtg aaccatgttg ttacactcta tttgtaacaa ggggaaagag     3900

agtggacgcc gacagcagcg gactccactg gttgtctcta acacccccga aaattaaacg     3960

gggctccacg ccaatggggc ccataaacaa agacaagtgg ccactctttt ttttgaaatt     4020

gtggagtggg ggcacgcgtc agcccccaca cgccgccctg cggttttgga ctgtaaaata     4080

agggtgtaat aacttggctg attgtaaccc cgctaaccac tgcggtcaaa ccacttgccc     4140

acaaaaccac taatggcacc ccggggaata cctgcataag taggtgggcg ggccaagata     4200

ggggcgcgat tgctgcgatc tggaggacaa attacacaca cttgcgcctg agcgccaagc     4260

acagggttgt tggtcctcat attcacgagg tcgctgagag cacggtgggc taatgttgcc     4320

atgggtagca tatactaccc aaatatctgg atagcatatg ctatcctaat ctatatctgg     4380

gtagcatagg ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg     4440

gtagtatatg ctatcctaat ttatatctgg gtagcatagg ctatcctaat ctatatctgg     4500

gtagcatatg ctatcctaat ctatatctgg gtagtatatg ctatcctaat ctgtatccgg     4560

gtagcatatg ctatcctaat agagattagg gtagtatatg ctatcctaat ttatatctgg     4620

gtagcatata ctacccaaat atctggatag catatgctat cctaatctat atctgggtag     4680

catatgctat cctaatctat atctgggtag cataggctat cctaatctat atctgggtag     4740

catatgctat cctaatctat atctgggtag tatatgctat cctaatttat atctgggtag     4800

cataggctat cctaatctat atctgggtag catatgctat cctaatctat atctgggtag     4860

tatatgctat cctaatctgt atccgggtag catatgctat cctcatgata agctgtcaaa     4920

catgagaatt ttcttgaaga cgaaagggcc tcgtgatacg cctattttta taggttaatg     4980

tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa     5040

cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac     5100

cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg     5160

tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc     5220

tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg     5280

atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga     5340

gcacttttaa agttctgcta tgtggcgcgg tattatcccg tgttgacgcc gggcaagagc     5400

aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag     5460

aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga     5520

gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg     5580

cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga     5640

atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgcagcaatg gcaacaacgt     5700

tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact     5760

ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt     5820

ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg     5880

ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta     5940

tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac     6000

tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat ttttaattta     6060

aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt     6120

tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt     6180

tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt     6240

gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc     6300

agataccaaa tactgttctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg     6360

tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg     6420

ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt     6480

cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac     6540

tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg     6600

acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg     6660

gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat     6720

ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt     6780

tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg ttatcccctg     6840

attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc cgcagccgaa     6900

cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc     6960

ctctccccgc gcgttggccg attcattaat gcagctggca cgacaggttt cccgactgga     7020

aagcgggcag tgagcgcaac gcaattaatg tgagttagct cactcattag gcaccccagg     7080

ctttacactt tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc     7140

acacaggaaa cagctatgac catgattacg ccaagctcta gctagaggtc gagtccctcc     7200

ccagcaggca gaagtatgca aagcatgcat ctcaattagt cagcaaccat agtcccgccc     7260

ctaactccgc ccatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc     7320

tgactaattt tttttattta tgcagaggcc gaggccgcct cggcctctga gctattccag     7380

aagtagtgag gaggcttttt tggaggccta ggcttttgca aaaagctttg caaagatgga     7440

taaagtttta aacagagagg aatctttgca gctaatggac cttctaggtc ttgaaagg       7498


<210>  5
<211>  8144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP176 ; pHybE-mCg1 V1  

<400>  5
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgagc atttaaatgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcta     2280

aaacgacacc cccatctgtc tatccactgg cccctggatc tgctgcccaa actaactcca     2340

tggtgaccct gggatgcctg gtcaagggct atttccctga gccagtgaca gtgacctgga     2400

actctggatc cctgtccagc ggtgtgcaca ccttcccagc tgtcctgcag tctgacctct     2460

acactctgag cagctcagtg actgtcccct ccagcacctg gcccagcgag accgtcacct     2520

gcaacgttgc ccacccggcc agcagcacca aggtggacaa gaaaattgtg cccagggatt     2580

gtggttgtaa gccttgcata tgtacagtcc cagaagtatc atctgtcttc atcttccccc     2640

caaagcccaa ggatgtgctc accattactc tgactcctaa ggtcacgtgt gttgtggtag     2700

acatcagcaa ggatgatccc gaggtccagt tcagctggtt tgtagatgat gtggaggtgc     2760

acacagctca gacgcaaccc cgggaggagc agttcaacag cactttccgc tcagtcagtg     2820

aacttcccat catgcaccag gactggctca atggcaagga gttcaaatgc agggtcaaca     2880

gtgcagcttt ccctgccccc atcgagaaaa ccatctccaa aaccaaaggc agaccgaagg     2940

ctccacaggt gtacaccatt ccacctccca aggagcagat ggccaaggat aaagtcagtc     3000

tgacctgcat gataacagac ttcttccctg aagacattac tgtggagtgg cagtggaatg     3060

ggcagccagc ggagaactac aagaacactc agcccatcat ggacacagat ggctcttact     3120

tcgtctacag caagctcaat gtgcagaaga gcaactggga ggcaggaaat actttcacct     3180

gctctgtgtt acatgagggc ctgcacaacc accatactga gaagagcctc tcccactctc     3240

ctggtaaata agcggccgct cgaggccggc aaggccggat cccccgacct cgacctctgg     3300

ctaataaagg aaatttattt tcattgcaat agtgtgttgg aattttttgt gtctctcact     3360

cggaaggaca tatgggaggg caaatcattt ggtcgagatc cctcggagat ctctagctag     3420

aggatcgatc cccgccccgg acgaactaaa cctgactacg acatctctgc cccttcttcg     3480

cggggcagtg catgtaatcc cttcagttgg ttggtacaac ttgccaactg ggccctgttc     3540

cacatgtgac acgggggggg accaaacaca aaggggttct ctgactgtag ttgacatcct     3600

tataaatgga tgtgcacatt tgccaacact gagtggcttt catcctggag cagactttgc     3660

agtctgtgga ctgcaacaca acattgcctt tatgtgtaac tcttggctga agctcttaca     3720

ccaatgctgg gggacatgta cctcccaggg gcccaggaag actacgggag gctacaccaa     3780

cgtcaatcag aggggcctgt gtagctaccg ataagcggac cctcaagagg gcattagcaa     3840

tagtgtttat aaggccccct tgttaaccct aaacgggtag catatgcttc ccgggtagta     3900

gtatatacta tccagactaa ccctaattca atagcatatg ttacccaacg ggaagcatat     3960

gctatcgaat tagggttagt aaaagggtcc taaggaacag cgatatctcc caccccatga     4020

gctgtcacgg ttttatttac atggggtcag gattccacga gggtagtgaa ccattttagt     4080

cacaagggca gtggctgaag atcaaggagc gggcagtgaa ctctcctgaa tcttcgcctg     4140

cttcttcatt ctccttcgtt tagctaatag aataactgct gagttgtgaa cagtaaggtg     4200

tatgtgaggt gctcgaaaac aaggtttcag gtgacgcccc cagaataaaa tttggacggg     4260

gggttcagtg gtggcattgt gctatgacac caatataacc ctcacaaacc ccttgggcaa     4320

taaatactag tgtaggaatg aaacattctg aatatcttta acaatagaaa tccatggggt     4380

ggggacaagc cgtaaagact ggatgtccat ctcacacgaa tttatggcta tgggcaacac     4440

ataatcctag tgcaatatga tactggggtt attaagatgt gtcccaggca gggaccaaga     4500

caggtgaacc atgttgttac actctatttg taacaagggg aaagagagtg gacgccgaca     4560

gcagcggact ccactggttg tctctaacac ccccgaaaat taaacggggc tccacgccaa     4620

tggggcccat aaacaaagac aagtggccac tctttttttt gaaattgtgg agtgggggca     4680

cgcgtcagcc cccacacgcc gccctgcggt tttggactgt aaaataaggg tgtaataact     4740

tggctgattg taaccccgct aaccactgcg gtcaaaccac ttgcccacaa aaccactaat     4800

ggcaccccgg ggaatacctg cataagtagg tgggcgggcc aagatagggg cgcgattgct     4860

gcgatctgga ggacaaatta cacacacttg cgcctgagcg ccaagcacag ggttgttggt     4920

cctcatattc acgaggtcgc tgagagcacg gtgggctaat gttgccatgg gtagcatata     4980

ctacccaaat atctggatag catatgctat cctaatctat atctgggtag cataggctat     5040

cctaatctat atctgggtag catatgctat cctaatctat atctgggtag tatatgctat     5100

cctaatttat atctgggtag cataggctat cctaatctat atctgggtag catatgctat     5160

cctaatctat atctgggtag tatatgctat cctaatctgt atccgggtag catatgctat     5220

cctaatagag attagggtag tatatgctat cctaatttat atctgggtag catatactac     5280

ccaaatatct ggatagcata tgctatccta atctatatct gggtagcata tgctatccta     5340

atctatatct gggtagcata ggctatccta atctatatct gggtagcata tgctatccta     5400

atctatatct gggtagtata tgctatccta atttatatct gggtagcata ggctatccta     5460

atctatatct gggtagcata tgctatccta atctatatct gggtagtata tgctatccta     5520

atctgtatcc gggtagcata tgctatcctc atgataagct gtcaaacatg agaattttct     5580

tgaagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg     5640

gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta     5700

tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt     5760

caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc     5820

ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa     5880

gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt     5940

aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt     6000

ctgctatgtg gcgcggtatt atcccgtgtt gacgccgggc aagagcaact cggtcgccgc     6060

atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg     6120

gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg     6180

gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac     6240

atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca     6300

aacgacgagc gtgacaccac gatgcctgca gcaatggcaa caacgttgcg caaactatta     6360

actggcgaac tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat     6420

aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa     6480

tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag     6540

ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat     6600

agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt     6660

tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg     6720

aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga     6780

gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta     6840

atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa     6900

gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact     6960

gttcttctag tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca     7020

tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt     7080

accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg     7140

ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag     7200

cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta     7260

agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat     7320

ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg     7380

tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc     7440

ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac     7500

cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc     7560

gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt     7620

tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc gggcagtgag     7680

cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg     7740

cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac aggaaacagc     7800

tatgaccatg attacgccaa gctctagcta gaggtcgagt ccctccccag caggcagaag     7860

tatgcaaagc atgcatctca attagtcagc aaccatagtc ccgcccctaa ctccgcccat     7920

cccgccccta actccgccca gttccgccca ttctccgccc catggctgac taattttttt     7980

tatttatgca gaggccgagg ccgcctcggc ctctgagcta ttccagaagt agtgaggagg     8040

cttttttgga ggcctaggct tttgcaaaaa gctttgcaaa gatggataaa gttttaaaca     8100

gagaggaatc tttgcagcta atggaccttc taggtcttga aagg                      8144


<210>  6
<211>  8144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP189 ; pHybE-mCg1 V2 

<400>  6
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgaga tccattgtgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcta     2280

aaacgacacc cccatctgtc tatccactgg cccctggatc tgctgcccaa actaactcca     2340

tggtgaccct gggatgcctg gtcaagggct atttccctga gccagtgaca gtgacctgga     2400

actctggatc cctgtccagc ggtgtgcaca ccttcccagc tgtcctgcag tctgacctct     2460

acactctgag cagctcagtg actgtcccct ccagcacctg gcccagcgag accgtcacct     2520

gcaacgttgc ccacccggcc agcagcacca aggtggacaa gaaaattgtg cccagggatt     2580

gtggttgtaa gccttgcata tgtacagtcc cagaagtatc atctgtcttc atcttccccc     2640

caaagcccaa ggatgtgctc accattactc tgactcctaa ggtcacgtgt gttgtggtag     2700

acatcagcaa ggatgatccc gaggtccagt tcagctggtt tgtagatgat gtggaggtgc     2760

acacagctca gacgcaaccc cgggaggagc agttcaacag cactttccgc tcagtcagtg     2820

aacttcccat catgcaccag gactggctca atggcaagga gttcaaatgc agggtcaaca     2880

gtgcagcttt ccctgccccc atcgagaaaa ccatctccaa aaccaaaggc agaccgaagg     2940

ctccacaggt gtacaccatt ccacctccca aggagcagat ggccaaggat aaagtcagtc     3000

tgacctgcat gataacagac ttcttccctg aagacattac tgtggagtgg cagtggaatg     3060

ggcagccagc ggagaactac aagaacactc agcccatcat ggacacagat ggctcttact     3120

tcgtctacag caagctcaat gtgcagaaga gcaactggga ggcaggaaat actttcacct     3180

gctctgtgtt acatgagggc ctgcacaacc accatactga gaagagcctc tcccactctc     3240

ctggtaaata agcggccgct cgaggccggc aaggccggat cccccgacct cgacctctgg     3300

ctaataaagg aaatttattt tcattgcaat agtgtgttgg aattttttgt gtctctcact     3360

cggaaggaca tatgggaggg caaatcattt ggtcgagatc cctcggagat ctctagctag     3420

aggatcgatc cccgccccgg acgaactaaa cctgactacg acatctctgc cccttcttcg     3480

cggggcagtg catgtaatcc cttcagttgg ttggtacaac ttgccaactg ggccctgttc     3540

cacatgtgac acgggggggg accaaacaca aaggggttct ctgactgtag ttgacatcct     3600

tataaatgga tgtgcacatt tgccaacact gagtggcttt catcctggag cagactttgc     3660

agtctgtgga ctgcaacaca acattgcctt tatgtgtaac tcttggctga agctcttaca     3720

ccaatgctgg gggacatgta cctcccaggg gcccaggaag actacgggag gctacaccaa     3780

cgtcaatcag aggggcctgt gtagctaccg ataagcggac cctcaagagg gcattagcaa     3840

tagtgtttat aaggccccct tgttaaccct aaacgggtag catatgcttc ccgggtagta     3900

gtatatacta tccagactaa ccctaattca atagcatatg ttacccaacg ggaagcatat     3960

gctatcgaat tagggttagt aaaagggtcc taaggaacag cgatatctcc caccccatga     4020

gctgtcacgg ttttatttac atggggtcag gattccacga gggtagtgaa ccattttagt     4080

cacaagggca gtggctgaag atcaaggagc gggcagtgaa ctctcctgaa tcttcgcctg     4140

cttcttcatt ctccttcgtt tagctaatag aataactgct gagttgtgaa cagtaaggtg     4200

tatgtgaggt gctcgaaaac aaggtttcag gtgacgcccc cagaataaaa tttggacggg     4260

gggttcagtg gtggcattgt gctatgacac caatataacc ctcacaaacc ccttgggcaa     4320

taaatactag tgtaggaatg aaacattctg aatatcttta acaatagaaa tccatggggt     4380

ggggacaagc cgtaaagact ggatgtccat ctcacacgaa tttatggcta tgggcaacac     4440

ataatcctag tgcaatatga tactggggtt attaagatgt gtcccaggca gggaccaaga     4500

caggtgaacc atgttgttac actctatttg taacaagggg aaagagagtg gacgccgaca     4560

gcagcggact ccactggttg tctctaacac ccccgaaaat taaacggggc tccacgccaa     4620

tggggcccat aaacaaagac aagtggccac tctttttttt gaaattgtgg agtgggggca     4680

cgcgtcagcc cccacacgcc gccctgcggt tttggactgt aaaataaggg tgtaataact     4740

tggctgattg taaccccgct aaccactgcg gtcaaaccac ttgcccacaa aaccactaat     4800

ggcaccccgg ggaatacctg cataagtagg tgggcgggcc aagatagggg cgcgattgct     4860

gcgatctgga ggacaaatta cacacacttg cgcctgagcg ccaagcacag ggttgttggt     4920

cctcatattc acgaggtcgc tgagagcacg gtgggctaat gttgccatgg gtagcatata     4980

ctacccaaat atctggatag catatgctat cctaatctat atctgggtag cataggctat     5040

cctaatctat atctgggtag catatgctat cctaatctat atctgggtag tatatgctat     5100

cctaatttat atctgggtag cataggctat cctaatctat atctgggtag catatgctat     5160

cctaatctat atctgggtag tatatgctat cctaatctgt atccgggtag catatgctat     5220

cctaatagag attagggtag tatatgctat cctaatttat atctgggtag catatactac     5280

ccaaatatct ggatagcata tgctatccta atctatatct gggtagcata tgctatccta     5340

atctatatct gggtagcata ggctatccta atctatatct gggtagcata tgctatccta     5400

atctatatct gggtagtata tgctatccta atttatatct gggtagcata ggctatccta     5460

atctatatct gggtagcata tgctatccta atctatatct gggtagtata tgctatccta     5520

atctgtatcc gggtagcata tgctatcctc atgataagct gtcaaacatg agaattttct     5580

tgaagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg     5640

gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta     5700

tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt     5760

caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc     5820

ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa     5880

gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt     5940

aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt     6000

ctgctatgtg gcgcggtatt atcccgtgtt gacgccgggc aagagcaact cggtcgccgc     6060

atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg     6120

gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg     6180

gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac     6240

atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca     6300

aacgacgagc gtgacaccac gatgcctgca gcaatggcaa caacgttgcg caaactatta     6360

actggcgaac tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat     6420

aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa     6480

tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag     6540

ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat     6600

agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt     6660

tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg     6720

aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga     6780

gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta     6840

atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa     6900

gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact     6960

gttcttctag tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca     7020

tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt     7080

accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg     7140

ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag     7200

cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta     7260

agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat     7320

ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg     7380

tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc     7440

ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac     7500

cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc     7560

gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt     7620

tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc gggcagtgag     7680

cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt acactttatg     7740

cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac aggaaacagc     7800

tatgaccatg attacgccaa gctctagcta gaggtcgagt ccctccccag caggcagaag     7860

tatgcaaagc atgcatctca attagtcagc aaccatagtc ccgcccctaa ctccgcccat     7920

cccgccccta actccgccca gttccgccca ttctccgccc catggctgac taattttttt     7980

tatttatgca gaggccgagg ccgcctcggc ctctgagcta ttccagaagt agtgaggagg     8040

cttttttgga ggcctaggct tttgcaaaaa gctttgcaaa gatggataaa gttttaaaca     8100

gagaggaatc tttgcagcta atggaccttc taggtcttga aagg                      8144


<210>  7
<211>  8162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP177 ; pHybE-mCg2a V1

<400>  7
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgagc atttaaatgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcta     2280

aaacaacagc cccatcggtc tatccactgg cccctgtgtg tggagataca actggctcct     2340

cggtgactct aggatgcctg gtcaagggtt atttccctga gccagtgacc ttgacctgga     2400

actctggatc cctgtccagt ggtgtgcaca ccttcccagc tgtcctgcag tctgacctct     2460

acaccctcag cagctcagtg actgtaacct cgagcacctg gcccagccag tccatcacct     2520

gcaatgtggc ccacccggca agcagcacca aggtggacaa gaaaattgag cccagagggc     2580

ccacaatcaa gccctgtcct ccatgcaaat gcccagcacc taacctcttg ggtggaccat     2640

ccgtcttcat cttccctcca aagatcaagg atgtactcat gatctccctg agccccatag     2700

tcacatgtgt ggtggtggat gtgagcgagg atgacccaga tgtccagatc agctggtttg     2760

tgaacaacgt ggaagtacac acagctcaga cacaaaccca tagagaggat tacaacagta     2820

ctctccgggt ggtcagtgcc ctccccatcc agcaccagga ctggatgagt ggcaaggagt     2880

tcaaatgcaa ggtcaacaac aaagacctcc cagcgcccat cgagagaacc atctcaaaac     2940

ccaaagggtc agtaagagct ccacaggtat atgtcttgcc tccaccagaa gaagagatga     3000

ctaagaaaca ggtcactctg acctgcatgg tcacagactt catgcctgaa gacatttacg     3060

tggagtggac caacaacggg aaaacagagc taaactacaa gaacactgaa ccagtcctgg     3120

actctgatgg ttcttacttc atgtacagca agctgagagt ggaaaagaag aactgggtgg     3180

aaagaaatag ctactcctgt tcagtggtcc acgagggtct gcacaatcac cacacgacta     3240

agagcttctc ccggactccg ggtaaataag cggccgctcg aggccggcaa ggccggatcc     3300

cccgacctcg acctctggct aataaaggaa atttattttc attgcaatag tgtgttggaa     3360

ttttttgtgt ctctcactcg gaaggacata tgggagggca aatcatttgg tcgagatccc     3420

tcggagatct ctagctagag gatcgatccc cgccccggac gaactaaacc tgactacgac     3480

atctctgccc cttcttcgcg gggcagtgca tgtaatccct tcagttggtt ggtacaactt     3540

gccaactggg ccctgttcca catgtgacac ggggggggac caaacacaaa ggggttctct     3600

gactgtagtt gacatcctta taaatggatg tgcacatttg ccaacactga gtggctttca     3660

tcctggagca gactttgcag tctgtggact gcaacacaac attgccttta tgtgtaactc     3720

ttggctgaag ctcttacacc aatgctgggg gacatgtacc tcccaggggc ccaggaagac     3780

tacgggaggc tacaccaacg tcaatcagag gggcctgtgt agctaccgat aagcggaccc     3840

tcaagagggc attagcaata gtgtttataa ggcccccttg ttaaccctaa acgggtagca     3900

tatgcttccc gggtagtagt atatactatc cagactaacc ctaattcaat agcatatgtt     3960

acccaacggg aagcatatgc tatcgaatta gggttagtaa aagggtccta aggaacagcg     4020

atatctccca ccccatgagc tgtcacggtt ttatttacat ggggtcagga ttccacgagg     4080

gtagtgaacc attttagtca caagggcagt ggctgaagat caaggagcgg gcagtgaact     4140

ctcctgaatc ttcgcctgct tcttcattct ccttcgttta gctaatagaa taactgctga     4200

gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa ggtttcaggt gacgccccca     4260

gaataaaatt tggacggggg gttcagtggt ggcattgtgc tatgacacca atataaccct     4320

cacaaacccc ttgggcaata aatactagtg taggaatgaa acattctgaa tatctttaac     4380

aatagaaatc catggggtgg ggacaagccg taaagactgg atgtccatct cacacgaatt     4440

tatggctatg ggcaacacat aatcctagtg caatatgata ctggggttat taagatgtgt     4500

cccaggcagg gaccaagaca ggtgaaccat gttgttacac tctatttgta acaaggggaa     4560

agagagtgga cgccgacagc agcggactcc actggttgtc tctaacaccc ccgaaaatta     4620

aacggggctc cacgccaatg gggcccataa acaaagacaa gtggccactc ttttttttga     4680

aattgtggag tgggggcacg cgtcagcccc cacacgccgc cctgcggttt tggactgtaa     4740

aataagggtg taataacttg gctgattgta accccgctaa ccactgcggt caaaccactt     4800

gcccacaaaa ccactaatgg caccccgggg aatacctgca taagtaggtg ggcgggccaa     4860

gataggggcg cgattgctgc gatctggagg acaaattaca cacacttgcg cctgagcgcc     4920

aagcacaggg ttgttggtcc tcatattcac gaggtcgctg agagcacggt gggctaatgt     4980

tgccatgggt agcatatact acccaaatat ctggatagca tatgctatcc taatctatat     5040

ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat     5100

ctgggtagta tatgctatcc taatttatat ctgggtagca taggctatcc taatctatat     5160

ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc taatctgtat     5220

ccgggtagca tatgctatcc taatagagat tagggtagta tatgctatcc taatttatat     5280

ctgggtagca tatactaccc aaatatctgg atagcatatg ctatcctaat ctatatctgg     5340

gtagcatatg ctatcctaat ctatatctgg gtagcatagg ctatcctaat ctatatctgg     5400

gtagcatatg ctatcctaat ctatatctgg gtagtatatg ctatcctaat ttatatctgg     5460

gtagcatagg ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg     5520

gtagtatatg ctatcctaat ctgtatccgg gtagcatatg ctatcctcat gataagctgt     5580

caaacatgag aattttcttg aagacgaaag ggcctcgtga tacgcctatt tttataggtt     5640

aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc     5700

ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa     5760

taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc     5820

cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa     5880

acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa     5940

ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg     6000

atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtgttga cgccgggcaa     6060

gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc     6120

acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc     6180

atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta     6240

accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag     6300

ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgcagc aatggcaaca     6360

acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca acaattaata     6420

gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc     6480

tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca     6540

ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca     6600

actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg     6660

taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa     6720

tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt     6780

gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat     6840

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     6900

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     6960

gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac     7020

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     7080

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     7140

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     7200

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     7260

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     7320

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     7380

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     7440

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc     7500

cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc     7560

cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa     7620

ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac     7680

tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc     7740

caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa     7800

tttcacacag gaaacagcta tgaccatgat tacgccaagc tctagctaga ggtcgagtcc     7860

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc     7920

gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca     7980

tggctgacta atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt     8040

ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tttgcaaaga     8100

tggataaagt tttaaacaga gaggaatctt tgcagctaat ggaccttcta ggtcttgaaa     8160

gg                                                                    8162


<210>  8
<211>  8162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP190 ; pHybE-mCg2a V2

<400>  8
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgaga tccattgtgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcta     2280

aaacaacagc cccatcggtc tatccactgg cccctgtgtg tggagataca actggctcct     2340

cggtgactct aggatgcctg gtcaagggtt atttccctga gccagtgacc ttgacctgga     2400

actctggatc cctgtccagt ggtgtgcaca ccttcccagc tgtcctgcag tctgacctct     2460

acaccctcag cagctcagtg actgtaacct cgagcacctg gcccagccag tccatcacct     2520

gcaatgtggc ccacccggca agcagcacca aggtggacaa gaaaattgag cccagagggc     2580

ccacaatcaa gccctgtcct ccatgcaaat gcccagcacc taacctcttg ggtggaccat     2640

ccgtcttcat cttccctcca aagatcaagg atgtactcat gatctccctg agccccatag     2700

tcacatgtgt ggtggtggat gtgagcgagg atgacccaga tgtccagatc agctggtttg     2760

tgaacaacgt ggaagtacac acagctcaga cacaaaccca tagagaggat tacaacagta     2820

ctctccgggt ggtcagtgcc ctccccatcc agcaccagga ctggatgagt ggcaaggagt     2880

tcaaatgcaa ggtcaacaac aaagacctcc cagcgcccat cgagagaacc atctcaaaac     2940

ccaaagggtc agtaagagct ccacaggtat atgtcttgcc tccaccagaa gaagagatga     3000

ctaagaaaca ggtcactctg acctgcatgg tcacagactt catgcctgaa gacatttacg     3060

tggagtggac caacaacggg aaaacagagc taaactacaa gaacactgaa ccagtcctgg     3120

actctgatgg ttcttacttc atgtacagca agctgagagt ggaaaagaag aactgggtgg     3180

aaagaaatag ctactcctgt tcagtggtcc acgagggtct gcacaatcac cacacgacta     3240

agagcttctc ccggactccg ggtaaataag cggccgctcg aggccggcaa ggccggatcc     3300

cccgacctcg acctctggct aataaaggaa atttattttc attgcaatag tgtgttggaa     3360

ttttttgtgt ctctcactcg gaaggacata tgggagggca aatcatttgg tcgagatccc     3420

tcggagatct ctagctagag gatcgatccc cgccccggac gaactaaacc tgactacgac     3480

atctctgccc cttcttcgcg gggcagtgca tgtaatccct tcagttggtt ggtacaactt     3540

gccaactggg ccctgttcca catgtgacac ggggggggac caaacacaaa ggggttctct     3600

gactgtagtt gacatcctta taaatggatg tgcacatttg ccaacactga gtggctttca     3660

tcctggagca gactttgcag tctgtggact gcaacacaac attgccttta tgtgtaactc     3720

ttggctgaag ctcttacacc aatgctgggg gacatgtacc tcccaggggc ccaggaagac     3780

tacgggaggc tacaccaacg tcaatcagag gggcctgtgt agctaccgat aagcggaccc     3840

tcaagagggc attagcaata gtgtttataa ggcccccttg ttaaccctaa acgggtagca     3900

tatgcttccc gggtagtagt atatactatc cagactaacc ctaattcaat agcatatgtt     3960

acccaacggg aagcatatgc tatcgaatta gggttagtaa aagggtccta aggaacagcg     4020

atatctccca ccccatgagc tgtcacggtt ttatttacat ggggtcagga ttccacgagg     4080

gtagtgaacc attttagtca caagggcagt ggctgaagat caaggagcgg gcagtgaact     4140

ctcctgaatc ttcgcctgct tcttcattct ccttcgttta gctaatagaa taactgctga     4200

gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa ggtttcaggt gacgccccca     4260

gaataaaatt tggacggggg gttcagtggt ggcattgtgc tatgacacca atataaccct     4320

cacaaacccc ttgggcaata aatactagtg taggaatgaa acattctgaa tatctttaac     4380

aatagaaatc catggggtgg ggacaagccg taaagactgg atgtccatct cacacgaatt     4440

tatggctatg ggcaacacat aatcctagtg caatatgata ctggggttat taagatgtgt     4500

cccaggcagg gaccaagaca ggtgaaccat gttgttacac tctatttgta acaaggggaa     4560

agagagtgga cgccgacagc agcggactcc actggttgtc tctaacaccc ccgaaaatta     4620

aacggggctc cacgccaatg gggcccataa acaaagacaa gtggccactc ttttttttga     4680

aattgtggag tgggggcacg cgtcagcccc cacacgccgc cctgcggttt tggactgtaa     4740

aataagggtg taataacttg gctgattgta accccgctaa ccactgcggt caaaccactt     4800

gcccacaaaa ccactaatgg caccccgggg aatacctgca taagtaggtg ggcgggccaa     4860

gataggggcg cgattgctgc gatctggagg acaaattaca cacacttgcg cctgagcgcc     4920

aagcacaggg ttgttggtcc tcatattcac gaggtcgctg agagcacggt gggctaatgt     4980

tgccatgggt agcatatact acccaaatat ctggatagca tatgctatcc taatctatat     5040

ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat     5100

ctgggtagta tatgctatcc taatttatat ctgggtagca taggctatcc taatctatat     5160

ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc taatctgtat     5220

ccgggtagca tatgctatcc taatagagat tagggtagta tatgctatcc taatttatat     5280

ctgggtagca tatactaccc aaatatctgg atagcatatg ctatcctaat ctatatctgg     5340

gtagcatatg ctatcctaat ctatatctgg gtagcatagg ctatcctaat ctatatctgg     5400

gtagcatatg ctatcctaat ctatatctgg gtagtatatg ctatcctaat ttatatctgg     5460

gtagcatagg ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg     5520

gtagtatatg ctatcctaat ctgtatccgg gtagcatatg ctatcctcat gataagctgt     5580

caaacatgag aattttcttg aagacgaaag ggcctcgtga tacgcctatt tttataggtt     5640

aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc     5700

ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa     5760

taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc     5820

cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa     5880

acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa     5940

ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg     6000

atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtgttga cgccgggcaa     6060

gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc     6120

acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc     6180

atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta     6240

accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag     6300

ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgcagc aatggcaaca     6360

acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca acaattaata     6420

gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc     6480

tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca     6540

ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca     6600

actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg     6660

taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa     6720

tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt     6780

gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat     6840

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     6900

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     6960

gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac     7020

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     7080

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     7140

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     7200

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     7260

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     7320

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     7380

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     7440

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc     7500

cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc     7560

cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa     7620

ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac     7680

tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc     7740

caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa     7800

tttcacacag gaaacagcta tgaccatgat tacgccaagc tctagctaga ggtcgagtcc     7860

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc     7920

gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca     7980

tggctgacta atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt     8040

ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tttgcaaaga     8100

tggataaagt tttaaacaga gaggaatctt tgcagctaat ggaccttcta ggtcttgaaa     8160

gg                                                                    8162


<210>  9
<211>  7503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP178 ; pHybE-hCk V1   

<400>  9
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgagc atttaaatgc ccgggcgcac catggacatg cgcgtgcccg     1260

cccagctgct gggcctgctg ctgctgtggt tccccggctc gcgatgcgca tggtatgccg     1320

aaagggatgc tgaaattgag aacgaaaagc tgcgccggga ggttgaagaa ctgcggcagg     1380

ccagcgaggc agatctccag ccaggaacta ttgagtacga acgccatcga cttacgcgtg     1440

cgcaggccga cgcacaggaa ctgaagaatg ccagagactc cgctgaagtg gtggaaaccg     1500

cattctgtac tttcgtgctg tcgcggatcg caggtgaaat tgccagtatt ctcgacgggc     1560

tccccctgtc ggtgcagcgg cgttttccgg aactggaaaa ccgacatgtt gatttcctga     1620

aacgggatat catcaaagcc atgaacaaag cagccgcgct ggatgaactg ataccggggt     1680

tgctgagtga atatatcgaa cagtcaggtt aacaggctgc ggcattttgt ccgcgccggg     1740

cttcgctcac tgttcaggcc ggagccacag accgccgttg aatgggcgga tgctaattac     1800

tatctcccga aagaatccgc ataccaggaa gggcgctggg aaacactgcc ctttcagcgg     1860

gccatcatga atgcgatggg cagcgactac atccgtgagg tgaatgtggt gaagtctgcc     1920

cgtgtcggtt attccaaaat gctgctgggt gtttatgcct actttataga gcataagcag     1980

cgcaacaccc ttatctggtt gccgacggat ggtgatgccg agaactttat gaaaacccac     2040

gttgagccga ctattcgtga tattccgtcg ctgctggcgc tggccccgtg gtatggcaaa     2100

aagcaccggg ataacacgct caccatgaag cgtttcacta atgggcgtgg cttctggtgc     2160

ctgggcggta aagcggcaaa aaactaccgt gaaaagtcgg tggatgtggc gggttatgat     2220

gaacttgctg cttttgatga tgatattgaa caggaaggct ctccgacgtt cctgggtgac     2280

aagctacgta cggtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg     2340

aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa     2400

gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgtcacagag     2460

caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag caaagcagac     2520

tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc     2580

acaaagagct tcaacagggg agagtgttga gcggccgctc gaggccggca aggccggatc     2640

ccccgacctc gacctctggc taataaagga aatttatttt cattgcaata gtgtgttgga     2700

attttttgtg tctctcactc ggaaggacat atgggagggc aaatcatttg gtcgagatcc     2760

ctcggagatc tctagctaga ggatcgatcc ccgccccgga cgaactaaac ctgactacga     2820

catctctgcc ccttcttcgc ggggcagtgc atgtaatccc ttcagttggt tggtacaact     2880

tgccaactgg gccctgttcc acatgtgaca cgggggggga ccaaacacaa aggggttctc     2940

tgactgtagt tgacatcctt ataaatggat gtgcacattt gccaacactg agtggctttc     3000

atcctggagc agactttgca gtctgtggac tgcaacacaa cattgccttt atgtgtaact     3060

cttggctgaa gctcttacac caatgctggg ggacatgtac ctcccagggg cccaggaaga     3120

ctacgggagg ctacaccaac gtcaatcaga ggggcctgtg tagctaccga taagcggacc     3180

ctcaagaggg cattagcaat agtgtttata aggccccctt gttaacccta aacgggtagc     3240

atatgcttcc cgggtagtag tatatactat ccagactaac cctaattcaa tagcatatgt     3300

tacccaacgg gaagcatatg ctatcgaatt agggttagta aaagggtcct aaggaacagc     3360

gatatctccc accccatgag ctgtcacggt tttatttaca tggggtcagg attccacgag     3420

ggtagtgaac cattttagtc acaagggcag tggctgaaga tcaaggagcg ggcagtgaac     3480

tctcctgaat cttcgcctgc ttcttcattc tccttcgttt agctaataga ataactgctg     3540

agttgtgaac agtaaggtgt atgtgaggtg ctcgaaaaca aggtttcagg tgacgccccc     3600

agaataaaat ttggacgggg ggttcagtgg tggcattgtg ctatgacacc aatataaccc     3660

tcacaaaccc cttgggcaat aaatactagt gtaggaatga aacattctga atatctttaa     3720

caatagaaat ccatggggtg gggacaagcc gtaaagactg gatgtccatc tcacacgaat     3780

ttatggctat gggcaacaca taatcctagt gcaatatgat actggggtta ttaagatgtg     3840

tcccaggcag ggaccaagac aggtgaacca tgttgttaca ctctatttgt aacaagggga     3900

aagagagtgg acgccgacag cagcggactc cactggttgt ctctaacacc cccgaaaatt     3960

aaacggggct ccacgccaat ggggcccata aacaaagaca agtggccact cttttttttg     4020

aaattgtgga gtgggggcac gcgtcagccc ccacacgccg ccctgcggtt ttggactgta     4080

aaataagggt gtaataactt ggctgattgt aaccccgcta accactgcgg tcaaaccact     4140

tgcccacaaa accactaatg gcaccccggg gaatacctgc ataagtaggt gggcgggcca     4200

agataggggc gcgattgctg cgatctggag gacaaattac acacacttgc gcctgagcgc     4260

caagcacagg gttgttggtc ctcatattca cgaggtcgct gagagcacgg tgggctaatg     4320

ttgccatggg tagcatatac tacccaaata tctggatagc atatgctatc ctaatctata     4380

tctgggtagc ataggctatc ctaatctata tctgggtagc atatgctatc ctaatctata     4440

tctgggtagt atatgctatc ctaatttata tctgggtagc ataggctatc ctaatctata     4500

tctgggtagc atatgctatc ctaatctata tctgggtagt atatgctatc ctaatctgta     4560

tccgggtagc atatgctatc ctaatagaga ttagggtagt atatgctatc ctaatttata     4620

tctgggtagc atatactacc caaatatctg gatagcatat gctatcctaa tctatatctg     4680

ggtagcatat gctatcctaa tctatatctg ggtagcatag gctatcctaa tctatatctg     4740

ggtagcatat gctatcctaa tctatatctg ggtagtatat gctatcctaa tttatatctg     4800

ggtagcatag gctatcctaa tctatatctg ggtagcatat gctatcctaa tctatatctg     4860

ggtagtatat gctatcctaa tctgtatccg ggtagcatat gctatcctca tgataagctg     4920

tcaaacatga gaattttctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt     4980

taatgtcatg ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg     5040

cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca     5100

ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt     5160

ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga     5220

aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga     5280

actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat     5340

gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca     5400

agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt     5460

cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac     5520

catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct     5580

aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga     5640

gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac     5700

aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat     5760

agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg     5820

ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc     5880

actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc     5940

aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg     6000

gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta     6060

atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg     6120

tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga     6180

tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt     6240

ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag     6300

agcgcagata ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa     6360

ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag     6420

tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca     6480

gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac     6540

cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa     6600

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc     6660

agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg     6720

tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc     6780

ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc     6840

ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag     6900

ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa     6960

accgcctctc cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca ggtttcccga     7020

ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt tagctcactc attaggcacc     7080

ccaggcttta cactttatgc ttccggctcg tatgttgtgt ggaattgtga gcggataaca     7140

atttcacaca ggaaacagct atgaccatga ttacgccaag ctctagctag aggtcgagtc     7200

cctccccagc aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accatagtcc     7260

cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc     7320

atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc tctgagctat     7380

tccagaagta gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag ctttgcaaag     7440

atggataaag ttttaaacag agaggaatct ttgcagctaa tggaccttct aggtcttgaa     7500

agg                                                                   7503


<210>  10
<211>  7503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP191 ; pHybE-hCk V2 

<400>  10
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgaga tccattgtgc ccgggcgcac catggacatg cgcgtgcccg     1260

cccagctgct gggcctgctg ctgctgtggt tccccggctc gcgatgcgca tggtatgccg     1320

aaagggatgc tgaaattgag aacgaaaagc tgcgccggga ggttgaagaa ctgcggcagg     1380

ccagcgaggc agatctccag ccaggaacta ttgagtacga acgccatcga cttacgcgtg     1440

cgcaggccga cgcacaggaa ctgaagaatg ccagagactc cgctgaagtg gtggaaaccg     1500

cattctgtac tttcgtgctg tcgcggatcg caggtgaaat tgccagtatt ctcgacgggc     1560

tccccctgtc ggtgcagcgg cgttttccgg aactggaaaa ccgacatgtt gatttcctga     1620

aacgggatat catcaaagcc atgaacaaag cagccgcgct ggatgaactg ataccggggt     1680

tgctgagtga atatatcgaa cagtcaggtt aacaggctgc ggcattttgt ccgcgccggg     1740

cttcgctcac tgttcaggcc ggagccacag accgccgttg aatgggcgga tgctaattac     1800

tatctcccga aagaatccgc ataccaggaa gggcgctggg aaacactgcc ctttcagcgg     1860

gccatcatga atgcgatggg cagcgactac atccgtgagg tgaatgtggt gaagtctgcc     1920

cgtgtcggtt attccaaaat gctgctgggt gtttatgcct actttataga gcataagcag     1980

cgcaacaccc ttatctggtt gccgacggat ggtgatgccg agaactttat gaaaacccac     2040

gttgagccga ctattcgtga tattccgtcg ctgctggcgc tggccccgtg gtatggcaaa     2100

aagcaccggg ataacacgct caccatgaag cgtttcacta atgggcgtgg cttctggtgc     2160

ctgggcggta aagcggcaaa aaactaccgt gaaaagtcgg tggatgtggc gggttatgat     2220

gaacttgctg cttttgatga tgatattgaa caggaaggct ctccgacgtt cctgggtgac     2280

aagctacgta cggtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg     2340

aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa     2400

gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgtcacagag     2460

caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag caaagcagac     2520

tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc     2580

acaaagagct tcaacagggg agagtgttga gcggccgctc gaggccggca aggccggatc     2640

ccccgacctc gacctctggc taataaagga aatttatttt cattgcaata gtgtgttgga     2700

attttttgtg tctctcactc ggaaggacat atgggagggc aaatcatttg gtcgagatcc     2760

ctcggagatc tctagctaga ggatcgatcc ccgccccgga cgaactaaac ctgactacga     2820

catctctgcc ccttcttcgc ggggcagtgc atgtaatccc ttcagttggt tggtacaact     2880

tgccaactgg gccctgttcc acatgtgaca cgggggggga ccaaacacaa aggggttctc     2940

tgactgtagt tgacatcctt ataaatggat gtgcacattt gccaacactg agtggctttc     3000

atcctggagc agactttgca gtctgtggac tgcaacacaa cattgccttt atgtgtaact     3060

cttggctgaa gctcttacac caatgctggg ggacatgtac ctcccagggg cccaggaaga     3120

ctacgggagg ctacaccaac gtcaatcaga ggggcctgtg tagctaccga taagcggacc     3180

ctcaagaggg cattagcaat agtgtttata aggccccctt gttaacccta aacgggtagc     3240

atatgcttcc cgggtagtag tatatactat ccagactaac cctaattcaa tagcatatgt     3300

tacccaacgg gaagcatatg ctatcgaatt agggttagta aaagggtcct aaggaacagc     3360

gatatctccc accccatgag ctgtcacggt tttatttaca tggggtcagg attccacgag     3420

ggtagtgaac cattttagtc acaagggcag tggctgaaga tcaaggagcg ggcagtgaac     3480

tctcctgaat cttcgcctgc ttcttcattc tccttcgttt agctaataga ataactgctg     3540

agttgtgaac agtaaggtgt atgtgaggtg ctcgaaaaca aggtttcagg tgacgccccc     3600

agaataaaat ttggacgggg ggttcagtgg tggcattgtg ctatgacacc aatataaccc     3660

tcacaaaccc cttgggcaat aaatactagt gtaggaatga aacattctga atatctttaa     3720

caatagaaat ccatggggtg gggacaagcc gtaaagactg gatgtccatc tcacacgaat     3780

ttatggctat gggcaacaca taatcctagt gcaatatgat actggggtta ttaagatgtg     3840

tcccaggcag ggaccaagac aggtgaacca tgttgttaca ctctatttgt aacaagggga     3900

aagagagtgg acgccgacag cagcggactc cactggttgt ctctaacacc cccgaaaatt     3960

aaacggggct ccacgccaat ggggcccata aacaaagaca agtggccact cttttttttg     4020

aaattgtgga gtgggggcac gcgtcagccc ccacacgccg ccctgcggtt ttggactgta     4080

aaataagggt gtaataactt ggctgattgt aaccccgcta accactgcgg tcaaaccact     4140

tgcccacaaa accactaatg gcaccccggg gaatacctgc ataagtaggt gggcgggcca     4200

agataggggc gcgattgctg cgatctggag gacaaattac acacacttgc gcctgagcgc     4260

caagcacagg gttgttggtc ctcatattca cgaggtcgct gagagcacgg tgggctaatg     4320

ttgccatggg tagcatatac tacccaaata tctggatagc atatgctatc ctaatctata     4380

tctgggtagc ataggctatc ctaatctata tctgggtagc atatgctatc ctaatctata     4440

tctgggtagt atatgctatc ctaatttata tctgggtagc ataggctatc ctaatctata     4500

tctgggtagc atatgctatc ctaatctata tctgggtagt atatgctatc ctaatctgta     4560

tccgggtagc atatgctatc ctaatagaga ttagggtagt atatgctatc ctaatttata     4620

tctgggtagc atatactacc caaatatctg gatagcatat gctatcctaa tctatatctg     4680

ggtagcatat gctatcctaa tctatatctg ggtagcatag gctatcctaa tctatatctg     4740

ggtagcatat gctatcctaa tctatatctg ggtagtatat gctatcctaa tttatatctg     4800

ggtagcatag gctatcctaa tctatatctg ggtagcatat gctatcctaa tctatatctg     4860

ggtagtatat gctatcctaa tctgtatccg ggtagcatat gctatcctca tgataagctg     4920

tcaaacatga gaattttctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt     4980

taatgtcatg ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg     5040

cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca     5100

ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt     5160

ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga     5220

aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga     5280

actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat     5340

gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca     5400

agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt     5460

cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac     5520

catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct     5580

aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga     5640

gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac     5700

aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat     5760

agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg     5820

ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc     5880

actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc     5940

aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg     6000

gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta     6060

atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg     6120

tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga     6180

tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt     6240

ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag     6300

agcgcagata ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa     6360

ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag     6420

tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca     6480

gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac     6540

cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa     6600

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc     6660

agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg     6720

tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc     6780

ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc     6840

ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag     6900

ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa     6960

accgcctctc cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca ggtttcccga     7020

ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt tagctcactc attaggcacc     7080

ccaggcttta cactttatgc ttccggctcg tatgttgtgt ggaattgtga gcggataaca     7140

atttcacaca ggaaacagct atgaccatga ttacgccaag ctctagctag aggtcgagtc     7200

cctccccagc aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accatagtcc     7260

cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc     7320

atggctgact aatttttttt atttatgcag aggccgaggc cgcctcggcc tctgagctat     7380

tccagaagta gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag ctttgcaaag     7440

atggataaag ttttaaacag agaggaatct ttgcagctaa tggaccttct aggtcttgaa     7500

agg                                                                   7503


<210>  11
<211>  7481
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP179 ; pHybE-hCl V1 

<400>  11
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgagc atttaaatgc ccgggcgcca ccatgacttg gaccccactc     1260

ctcttcctca ccctcctcct ccactgcaca ggaagcttat cgcgaaaggg atgctgaaat     1320

tgagaacgaa aagctgcgcc gggaggttga agaactgcgg caggccagcg aggcagatct     1380

ccagccagga actattgagt acgaacgcca tcgacttacg cgtgcgcagg ccgacgcaca     1440

ggaactgaag aatgccagag actccgctga agtggtggaa accgcattct gtactttcgt     1500

gctgtcgcgg atcgcaggtg aaattgccag tattctcgac gggctccccc tgtcggtgca     1560

gcggcgtttt ccggaactgg aaaaccgaca tgttgatttc ctgaaacggg atatcatcaa     1620

agccatgaac aaagcagccg cgctggatga actgataccg gggttgctga gtgaatatat     1680

cgaacagtca ggttaacagg ctgcggcatt ttgtccgcgc cgggcttcgc tcactgttca     1740

ggccggagcc acagaccgcc gttgaatggg cggatgctaa ttactatctc ccgaaagaat     1800

ccgcatacca ggaagggcgc tgggaaacac tgccctttca gcgggccatc atgaatgcga     1860

tgggcagcga ctacatccgt gaggtgaatg tggtgaagtc tgcccgtgtc ggttattcca     1920

aaatgctgct gggtgtttat gcctacttta tagagcataa gcagcgcaac acccttatct     1980

ggttgccgac ggatggtgat gccgagaact ttatgaaaac ccacgttgag ccgactattc     2040

gtgatattcc gtcgctgctg gcgctggccc cgtggtatgg caaaaagcac cgggataaca     2100

cgctcaccat gaagcgtttc actaatgggc gtggcttctg gtgcctgggc ggtaaagcgg     2160

caaaaaacta ccgtgaaaag tcggtggatg tggcgggtta tgatgaactt gctgcttttg     2220

atgatgatat tgaacaggaa ggctctccga cgttcctggg tgacaagcgt taacccaagg     2280

ctgccccctc ggtcactctg ttcccgccct cctctgagga gcttcaagcc aacaaggcca     2340

cactggtgtg tctcataagt gacttctacc cgggagccgt gacagtggcc tggaaggcag     2400

atagcagccc cgtcaaggcg ggagtggaga ccaccacacc ctccaaacaa agcaacaaca     2460

agtacgcggc cagcagctac ctgagcctga cgcctgagca gtggaagtcc cacagaagct     2520

acagctgcca ggtcacgcat gaagggagca ccgtggagaa gacagtggcc cctacagaat     2580

gttcatgagc ggccgctcga ggccggcaag gccggatccc ccgacctcga cctctggcta     2640

ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg     2700

aaggacatat gggagggcaa atcatttggt cgagatccct cggagatctc tagctagagg     2760

atcgatcccc gccccggacg aactaaacct gactacgaca tctctgcccc ttcttcgcgg     2820

ggcagtgcat gtaatccctt cagttggttg gtacaacttg ccaactgggc cctgttccac     2880

atgtgacacg gggggggacc aaacacaaag gggttctctg actgtagttg acatccttat     2940

aaatggatgt gcacatttgc caacactgag tggctttcat cctggagcag actttgcagt     3000

ctgtggactg caacacaaca ttgcctttat gtgtaactct tggctgaagc tcttacacca     3060

atgctggggg acatgtacct cccaggggcc caggaagact acgggaggct acaccaacgt     3120

caatcagagg ggcctgtgta gctaccgata agcggaccct caagagggca ttagcaatag     3180

tgtttataag gcccccttgt taaccctaaa cgggtagcat atgcttcccg ggtagtagta     3240

tatactatcc agactaaccc taattcaata gcatatgtta cccaacggga agcatatgct     3300

atcgaattag ggttagtaaa agggtcctaa ggaacagcga tatctcccac cccatgagct     3360

gtcacggttt tatttacatg gggtcaggat tccacgaggg tagtgaacca ttttagtcac     3420

aagggcagtg gctgaagatc aaggagcggg cagtgaactc tcctgaatct tcgcctgctt     3480

cttcattctc cttcgtttag ctaatagaat aactgctgag ttgtgaacag taaggtgtat     3540

gtgaggtgct cgaaaacaag gtttcaggtg acgcccccag aataaaattt ggacgggggg     3600

ttcagtggtg gcattgtgct atgacaccaa tataaccctc acaaacccct tgggcaataa     3660

atactagtgt aggaatgaaa cattctgaat atctttaaca atagaaatcc atggggtggg     3720

gacaagccgt aaagactgga tgtccatctc acacgaattt atggctatgg gcaacacata     3780

atcctagtgc aatatgatac tggggttatt aagatgtgtc ccaggcaggg accaagacag     3840

gtgaaccatg ttgttacact ctatttgtaa caaggggaaa gagagtggac gccgacagca     3900

gcggactcca ctggttgtct ctaacacccc cgaaaattaa acggggctcc acgccaatgg     3960

ggcccataaa caaagacaag tggccactct tttttttgaa attgtggagt gggggcacgc     4020

gtcagccccc acacgccgcc ctgcggtttt ggactgtaaa ataagggtgt aataacttgg     4080

ctgattgtaa ccccgctaac cactgcggtc aaaccacttg cccacaaaac cactaatggc     4140

accccgggga atacctgcat aagtaggtgg gcgggccaag ataggggcgc gattgctgcg     4200

atctggagga caaattacac acacttgcgc ctgagcgcca agcacagggt tgttggtcct     4260

catattcacg aggtcgctga gagcacggtg ggctaatgtt gccatgggta gcatatacta     4320

cccaaatatc tggatagcat atgctatcct aatctatatc tgggtagcat aggctatcct     4380

aatctatatc tgggtagcat atgctatcct aatctatatc tgggtagtat atgctatcct     4440

aatttatatc tgggtagcat aggctatcct aatctatatc tgggtagcat atgctatcct     4500

aatctatatc tgggtagtat atgctatcct aatctgtatc cgggtagcat atgctatcct     4560

aatagagatt agggtagtat atgctatcct aatttatatc tgggtagcat atactaccca     4620

aatatctgga tagcatatgc tatcctaatc tatatctggg tagcatatgc tatcctaatc     4680

tatatctggg tagcataggc tatcctaatc tatatctggg tagcatatgc tatcctaatc     4740

tatatctggg tagtatatgc tatcctaatt tatatctggg tagcataggc tatcctaatc     4800

tatatctggg tagcatatgc tatcctaatc tatatctggg tagtatatgc tatcctaatc     4860

tgtatccggg tagcatatgc tatcctcatg ataagctgtc aaacatgaga attttcttga     4920

agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat aataatggtt     4980

tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt     5040

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa     5100

taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt     5160

tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat     5220

gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag     5280

atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg     5340

ctatgtggcg cggtattatc ccgtgttgac gccgggcaag agcaactcgg tcgccgcata     5400

cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat     5460

ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc     5520

aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg     5580

ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac     5640

gacgagcgtg acaccacgat gcctgcagca atggcaacaa cgttgcgcaa actattaact     5700

ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa     5760

gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct     5820

ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc     5880

tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga     5940

cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac     6000

tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag     6060

atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg     6120

tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc     6180

tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag     6240

ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtt     6300

cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac     6360

ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc     6420

gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt     6480

tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt     6540

gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc     6600

ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt     6660

tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca     6720

ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt     6780

tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt     6840

attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag     6900

tcagtgagcg aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg     6960

ccgattcatt aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc     7020

aacgcaatta atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt     7080

ccggctcgta tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat     7140

gaccatgatt acgccaagct ctagctagag gtcgagtccc tccccagcag gcagaagtat     7200

gcaaagcatg catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc     7260

gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat     7320

ttatgcagag gccgaggccg cctcggcctc tgagctattc cagaagtagt gaggaggctt     7380

ttttggaggc ctaggctttt gcaaaaagct ttgcaaagat ggataaagtt ttaaacagag     7440

aggaatcttt gcagctaatg gaccttctag gtcttgaaag g                         7481


<210>  12
<211>  7486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP192 ; pHybE-hCl V2 

<400>  12
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgaga tccattgtgc ccgggcgcca ccatgacttg gaccccactc     1260

ctcttcctca ccctcctcct ccactgcaca ggaagcttat cgcgaaaggg atgctgaaat     1320

tgagaacgaa aagctgcgcc gggaggttga agaactgcgg caggccagcg aggcagatct     1380

ccagccagga actattgagt acgaacgcca tcgacttacg cgtgcgcagg ccgacgcaca     1440

ggaactgaag aatgccagag actccgctga agtggtggaa accgcattct gtactttcgt     1500

gctgtcgcgg atcgcaggtg aaattgccag tattctcgac gggctccccc tgtcggtgca     1560

gcggcgtttt ccggaactgg aaaaccgaca tgttgatttc ctgaaacggg atatcatcaa     1620

agccatgaac aaagcagccg cgctggatga actgataccg gggttgctga gtgaatatat     1680

cgaacagtca ggttaacagg ctgcggcatt ttgtccgcgc cgggcttcgc tcactgttca     1740

ggccggagcc acagaccgcc gttgaatggg cggatgctaa ttactatctc ccgaaagaat     1800

ccgcatacca ggaagggcgc tgggaaacac tgccctttca gcgggccatc atgaatgcga     1860

tgggcagcga ctacatccgt gaggtgaatg tggtgaagtc tgcccgtgtc ggttattcca     1920

aaatgctgct gggtgtttat gcctacttta tagagcataa gcagcgcaac acccttatct     1980

ggttgccgac ggatggtgat gccgagaact ttatgaaaac ccacgttgag ccgactattc     2040

gtgatattcc gtcgctgctg gcgctggccc cgtggtatgg caaaaagcac cgggataaca     2100

cgctcaccat gaagcgtttc actaatgggc gtggcttctg gtgcctgggc ggtaaagcgg     2160

caaaaaacta ccgtgaaaag tcggtggatg tggcgggtta tgatgaactt gctgcttttg     2220

atgatgatat tgaacaggaa ggctctccga cgttcctggg tgacaagcgc taggtcaacc     2280

caaggctgcc ccctcggtca ctctgttccc gccctcctct gaggagcttc aagccaacaa     2340

ggccacactg gtgtgtctca taagtgactt ctacccggga gccgtgacag tggcctggaa     2400

ggcagatagc agccccgtca aggcgggagt ggagaccacc acaccctcca aacaaagcaa     2460

caacaagtac gcggccagca gctacctgag cctgacgcct gagcagtgga agtcccacag     2520

aagctacagc tgccaggtca cgcatgaagg gagcaccgtg gagaagacag tggcccctac     2580

agaatgttca tgagcggccg ctcgaggccg gcaaggccgg atcccccgac ctcgacctct     2640

ggctaataaa ggaaatttat tttcattgca atagtgtgtt ggaatttttt gtgtctctca     2700

ctcggaagga catatgggag ggcaaatcat ttggtcgaga tccctcggag atctctagct     2760

agaggatcga tccccgcccc ggacgaacta aacctgacta cgacatctct gccccttctt     2820

cgcggggcag tgcatgtaat cccttcagtt ggttggtaca acttgccaac tgggccctgt     2880

tccacatgtg acacgggggg ggaccaaaca caaaggggtt ctctgactgt agttgacatc     2940

cttataaatg gatgtgcaca tttgccaaca ctgagtggct ttcatcctgg agcagacttt     3000

gcagtctgtg gactgcaaca caacattgcc tttatgtgta actcttggct gaagctctta     3060

caccaatgct gggggacatg tacctcccag gggcccagga agactacggg aggctacacc     3120

aacgtcaatc agaggggcct gtgtagctac cgataagcgg accctcaaga gggcattagc     3180

aatagtgttt ataaggcccc cttgttaacc ctaaacgggt agcatatgct tcccgggtag     3240

tagtatatac tatccagact aaccctaatt caatagcata tgttacccaa cgggaagcat     3300

atgctatcga attagggtta gtaaaagggt cctaaggaac agcgatatct cccaccccat     3360

gagctgtcac ggttttattt acatggggtc aggattccac gagggtagtg aaccatttta     3420

gtcacaaggg cagtggctga agatcaagga gcgggcagtg aactctcctg aatcttcgcc     3480

tgcttcttca ttctccttcg tttagctaat agaataactg ctgagttgtg aacagtaagg     3540

tgtatgtgag gtgctcgaaa acaaggtttc aggtgacgcc cccagaataa aatttggacg     3600

gggggttcag tggtggcatt gtgctatgac accaatataa ccctcacaaa ccccttgggc     3660

aataaatact agtgtaggaa tgaaacattc tgaatatctt taacaataga aatccatggg     3720

gtggggacaa gccgtaaaga ctggatgtcc atctcacacg aatttatggc tatgggcaac     3780

acataatcct agtgcaatat gatactgggg ttattaagat gtgtcccagg cagggaccaa     3840

gacaggtgaa ccatgttgtt acactctatt tgtaacaagg ggaaagagag tggacgccga     3900

cagcagcgga ctccactggt tgtctctaac acccccgaaa attaaacggg gctccacgcc     3960

aatggggccc ataaacaaag acaagtggcc actctttttt ttgaaattgt ggagtggggg     4020

cacgcgtcag cccccacacg ccgccctgcg gttttggact gtaaaataag ggtgtaataa     4080

cttggctgat tgtaaccccg ctaaccactg cggtcaaacc acttgcccac aaaaccacta     4140

atggcacccc ggggaatacc tgcataagta ggtgggcggg ccaagatagg ggcgcgattg     4200

ctgcgatctg gaggacaaat tacacacact tgcgcctgag cgccaagcac agggttgttg     4260

gtcctcatat tcacgaggtc gctgagagca cggtgggcta atgttgccat gggtagcata     4320

tactacccaa atatctggat agcatatgct atcctaatct atatctgggt agcataggct     4380

atcctaatct atatctgggt agcatatgct atcctaatct atatctgggt agtatatgct     4440

atcctaattt atatctgggt agcataggct atcctaatct atatctgggt agcatatgct     4500

atcctaatct atatctgggt agtatatgct atcctaatct gtatccgggt agcatatgct     4560

atcctaatag agattagggt agtatatgct atcctaattt atatctgggt agcatatact     4620

acccaaatat ctggatagca tatgctatcc taatctatat ctgggtagca tatgctatcc     4680

taatctatat ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc     4740

taatctatat ctgggtagta tatgctatcc taatttatat ctgggtagca taggctatcc     4800

taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc     4860

taatctgtat ccgggtagca tatgctatcc tcatgataag ctgtcaaaca tgagaatttt     4920

cttgaagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc atgataataa     4980

tggtttctta gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt     5040

tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc     5100

ttcaataata ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc     5160

ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa     5220

aagatgctga agatcagttg ggtgcacgag tgggttacat cgaactggat ctcaacagcg     5280

gtaagatcct tgagagtttt cgccccgaag aacgttttcc aatgatgagc acttttaaag     5340

ttctgctatg tggcgcggta ttatcccgtg ttgacgccgg gcaagagcaa ctcggtcgcc     5400

gcatacacta ttctcagaat gacttggttg agtactcacc agtcacagaa aagcatctta     5460

cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt gataacactg     5520

cggccaactt acttctgaca acgatcggag gaccgaagga gctaaccgct tttttgcaca     5580

acatggggga tcatgtaact cgccttgatc gttgggaacc ggagctgaat gaagccatac     5640

caaacgacga gcgtgacacc acgatgcctg cagcaatggc aacaacgttg cgcaaactat     5700

taactggcga actacttact ctagcttccc ggcaacaatt aatagactgg atggaggcgg     5760

ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt attgctgata     5820

aatctggagc cggtgagcgt gggtctcgcg gtatcattgc agcactgggg ccagatggta     5880

agccctcccg tatcgtagtt atctacacga cggggagtca ggcaactatg gatgaacgaa     5940

atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg tcagaccaag     6000

tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg     6060

tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact     6120

gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg     6180

taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc     6240

aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata     6300

ctgttcttct agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta     6360

catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc     6420

ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg     6480

ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac     6540

agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg     6600

taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt     6660

atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct     6720

cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggttcctgg     6780

ccttttgctg gccttttgct cacatgttct ttcctgcgtt atcccctgat tctgtggata     6840

accgtattac cgcctttgag tgagctgata ccgctcgccg cagccgaacg accgagcgca     6900

gcgagtcagt gagcgaggaa gcggaagagc gcccaatacg caaaccgcct ctccccgcgc     6960

gttggccgat tcattaatgc agctggcacg acaggtttcc cgactggaaa gcgggcagtg     7020

agcgcaacgc aattaatgtg agttagctca ctcattaggc accccaggct ttacacttta     7080

tgcttccggc tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca     7140

gctatgacca tgattacgcc aagctctagc tagaggtcga gtccctcccc agcaggcaga     7200

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc     7260

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt     7320

tttatttatg cagaggccga ggccgcctcg gcctctgagc tattccagaa gtagtgagga     7380

ggcttttttg gaggcctagg cttttgcaaa aagctttgca aagatggata aagttttaaa     7440

cagagaggaa tctttgcagc taatggacct tctaggtctt gaaagg                    7486


<210>  13
<211>  8162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP170 ; pHybE-hCg1,z,a V1

<400>  13
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgagc atttaaatgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcgt     2280

cgaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca     2340

cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga     2400

actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac     2460

tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca     2520

tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt gagcccaaat     2580

cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg gggggaccgt     2640

cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg     2700

tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc aactggtacg     2760

tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag tacaacagca     2820

cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt     2880

acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc atctccaaag     2940

ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg gatgagctga     3000

ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc gacatcgccg     3060

tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct cccgtgctgg     3120

actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc aggtggcagc     3180

aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga     3240

agagcctctc cctgtctccg ggtaaatgag cggccgctcg aggccggcaa ggccggatcc     3300

cccgacctcg acctctggct aataaaggaa atttattttc attgcaatag tgtgttggaa     3360

ttttttgtgt ctctcactcg gaaggacata tgggagggca aatcatttgg tcgagatccc     3420

tcggagatct ctagctagag gatcgatccc cgccccggac gaactaaacc tgactacgac     3480

atctctgccc cttcttcgcg gggcagtgca tgtaatccct tcagttggtt ggtacaactt     3540

gccaactggg ccctgttcca catgtgacac ggggggggac caaacacaaa ggggttctct     3600

gactgtagtt gacatcctta taaatggatg tgcacatttg ccaacactga gtggctttca     3660

tcctggagca gactttgcag tctgtggact gcaacacaac attgccttta tgtgtaactc     3720

ttggctgaag ctcttacacc aatgctgggg gacatgtacc tcccaggggc ccaggaagac     3780

tacgggaggc tacaccaacg tcaatcagag gggcctgtgt agctaccgat aagcggaccc     3840

tcaagagggc attagcaata gtgtttataa ggcccccttg ttaaccctaa acgggtagca     3900

tatgcttccc gggtagtagt atatactatc cagactaacc ctaattcaat agcatatgtt     3960

acccaacggg aagcatatgc tatcgaatta gggttagtaa aagggtccta aggaacagcg     4020

atatctccca ccccatgagc tgtcacggtt ttatttacat ggggtcagga ttccacgagg     4080

gtagtgaacc attttagtca caagggcagt ggctgaagat caaggagcgg gcagtgaact     4140

ctcctgaatc ttcgcctgct tcttcattct ccttcgttta gctaatagaa taactgctga     4200

gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa ggtttcaggt gacgccccca     4260

gaataaaatt tggacggggg gttcagtggt ggcattgtgc tatgacacca atataaccct     4320

cacaaacccc ttgggcaata aatactagtg taggaatgaa acattctgaa tatctttaac     4380

aatagaaatc catggggtgg ggacaagccg taaagactgg atgtccatct cacacgaatt     4440

tatggctatg ggcaacacat aatcctagtg caatatgata ctggggttat taagatgtgt     4500

cccaggcagg gaccaagaca ggtgaaccat gttgttacac tctatttgta acaaggggaa     4560

agagagtgga cgccgacagc agcggactcc actggttgtc tctaacaccc ccgaaaatta     4620

aacggggctc cacgccaatg gggcccataa acaaagacaa gtggccactc ttttttttga     4680

aattgtggag tgggggcacg cgtcagcccc cacacgccgc cctgcggttt tggactgtaa     4740

aataagggtg taataacttg gctgattgta accccgctaa ccactgcggt caaaccactt     4800

gcccacaaaa ccactaatgg caccccgggg aatacctgca taagtaggtg ggcgggccaa     4860

gataggggcg cgattgctgc gatctggagg acaaattaca cacacttgcg cctgagcgcc     4920

aagcacaggg ttgttggtcc tcatattcac gaggtcgctg agagcacggt gggctaatgt     4980

tgccatgggt agcatatact acccaaatat ctggatagca tatgctatcc taatctatat     5040

ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat     5100

ctgggtagta tatgctatcc taatttatat ctgggtagca taggctatcc taatctatat     5160

ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc taatctgtat     5220

ccgggtagca tatgctatcc taatagagat tagggtagta tatgctatcc taatttatat     5280

ctgggtagca tatactaccc aaatatctgg atagcatatg ctatcctaat ctatatctgg     5340

gtagcatatg ctatcctaat ctatatctgg gtagcatagg ctatcctaat ctatatctgg     5400

gtagcatatg ctatcctaat ctatatctgg gtagtatatg ctatcctaat ttatatctgg     5460

gtagcatagg ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg     5520

gtagtatatg ctatcctaat ctgtatccgg gtagcatatg ctatcctcat gataagctgt     5580

caaacatgag aattttcttg aagacgaaag ggcctcgtga tacgcctatt tttataggtt     5640

aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc     5700

ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa     5760

taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc     5820

cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa     5880

acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa     5940

ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg     6000

atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtgttga cgccgggcaa     6060

gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc     6120

acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc     6180

atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta     6240

accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag     6300

ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgcagc aatggcaaca     6360

acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca acaattaata     6420

gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc     6480

tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca     6540

ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca     6600

actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg     6660

taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa     6720

tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt     6780

gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat     6840

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     6900

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     6960

gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac     7020

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     7080

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     7140

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     7200

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     7260

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     7320

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     7380

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     7440

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc     7500

cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc     7560

cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa     7620

ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac     7680

tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc     7740

caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa     7800

tttcacacag gaaacagcta tgaccatgat tacgccaagc tctagctaga ggtcgagtcc     7860

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc     7920

gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca     7980

tggctgacta atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt     8040

ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tttgcaaaga     8100

tggataaagt tttaaacaga gaggaatctt tgcagctaat ggaccttcta ggtcttgaaa     8160

gg                                                                    8162


<210>  14
<211>  8162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP182 ; pHybE-hCg1,z,a V2

<400>  14
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgaga tccattgtgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcgt     2280

cgaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca     2340

cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga     2400

actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac     2460

tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca     2520

tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt gagcccaaat     2580

cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg gggggaccgt     2640

cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg     2700

tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc aactggtacg     2760

tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag tacaacagca     2820

cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt     2880

acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc atctccaaag     2940

ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg gatgagctga     3000

ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc gacatcgccg     3060

tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct cccgtgctgg     3120

actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc aggtggcagc     3180

aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga     3240

agagcctctc cctgtctccg ggtaaatgag cggccgctcg aggccggcaa ggccggatcc     3300

cccgacctcg acctctggct aataaaggaa atttattttc attgcaatag tgtgttggaa     3360

ttttttgtgt ctctcactcg gaaggacata tgggagggca aatcatttgg tcgagatccc     3420

tcggagatct ctagctagag gatcgatccc cgccccggac gaactaaacc tgactacgac     3480

atctctgccc cttcttcgcg gggcagtgca tgtaatccct tcagttggtt ggtacaactt     3540

gccaactggg ccctgttcca catgtgacac ggggggggac caaacacaaa ggggttctct     3600

gactgtagtt gacatcctta taaatggatg tgcacatttg ccaacactga gtggctttca     3660

tcctggagca gactttgcag tctgtggact gcaacacaac attgccttta tgtgtaactc     3720

ttggctgaag ctcttacacc aatgctgggg gacatgtacc tcccaggggc ccaggaagac     3780

tacgggaggc tacaccaacg tcaatcagag gggcctgtgt agctaccgat aagcggaccc     3840

tcaagagggc attagcaata gtgtttataa ggcccccttg ttaaccctaa acgggtagca     3900

tatgcttccc gggtagtagt atatactatc cagactaacc ctaattcaat agcatatgtt     3960

acccaacggg aagcatatgc tatcgaatta gggttagtaa aagggtccta aggaacagcg     4020

atatctccca ccccatgagc tgtcacggtt ttatttacat ggggtcagga ttccacgagg     4080

gtagtgaacc attttagtca caagggcagt ggctgaagat caaggagcgg gcagtgaact     4140

ctcctgaatc ttcgcctgct tcttcattct ccttcgttta gctaatagaa taactgctga     4200

gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa ggtttcaggt gacgccccca     4260

gaataaaatt tggacggggg gttcagtggt ggcattgtgc tatgacacca atataaccct     4320

cacaaacccc ttgggcaata aatactagtg taggaatgaa acattctgaa tatctttaac     4380

aatagaaatc catggggtgg ggacaagccg taaagactgg atgtccatct cacacgaatt     4440

tatggctatg ggcaacacat aatcctagtg caatatgata ctggggttat taagatgtgt     4500

cccaggcagg gaccaagaca ggtgaaccat gttgttacac tctatttgta acaaggggaa     4560

agagagtgga cgccgacagc agcggactcc actggttgtc tctaacaccc ccgaaaatta     4620

aacggggctc cacgccaatg gggcccataa acaaagacaa gtggccactc ttttttttga     4680

aattgtggag tgggggcacg cgtcagcccc cacacgccgc cctgcggttt tggactgtaa     4740

aataagggtg taataacttg gctgattgta accccgctaa ccactgcggt caaaccactt     4800

gcccacaaaa ccactaatgg caccccgggg aatacctgca taagtaggtg ggcgggccaa     4860

gataggggcg cgattgctgc gatctggagg acaaattaca cacacttgcg cctgagcgcc     4920

aagcacaggg ttgttggtcc tcatattcac gaggtcgctg agagcacggt gggctaatgt     4980

tgccatgggt agcatatact acccaaatat ctggatagca tatgctatcc taatctatat     5040

ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat     5100

ctgggtagta tatgctatcc taatttatat ctgggtagca taggctatcc taatctatat     5160

ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc taatctgtat     5220

ccgggtagca tatgctatcc taatagagat tagggtagta tatgctatcc taatttatat     5280

ctgggtagca tatactaccc aaatatctgg atagcatatg ctatcctaat ctatatctgg     5340

gtagcatatg ctatcctaat ctatatctgg gtagcatagg ctatcctaat ctatatctgg     5400

gtagcatatg ctatcctaat ctatatctgg gtagtatatg ctatcctaat ttatatctgg     5460

gtagcatagg ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg     5520

gtagtatatg ctatcctaat ctgtatccgg gtagcatatg ctatcctcat gataagctgt     5580

caaacatgag aattttcttg aagacgaaag ggcctcgtga tacgcctatt tttataggtt     5640

aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc     5700

ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa     5760

taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc     5820

cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa     5880

acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa     5940

ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg     6000

atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtgttga cgccgggcaa     6060

gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc     6120

acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc     6180

atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta     6240

accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag     6300

ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgcagc aatggcaaca     6360

acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca acaattaata     6420

gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc     6480

tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca     6540

ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca     6600

actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg     6660

taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa     6720

tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt     6780

gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat     6840

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     6900

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     6960

gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac     7020

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     7080

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     7140

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     7200

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     7260

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     7320

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     7380

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     7440

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc     7500

cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc     7560

cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa     7620

ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac     7680

tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc     7740

caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa     7800

tttcacacag gaaacagcta tgaccatgat tacgccaagc tctagctaga ggtcgagtcc     7860

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc     7920

gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca     7980

tggctgacta atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt     8040

ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tttgcaaaga     8100

tggataaagt tttaaacaga gaggaatctt tgcagctaat ggaccttcta ggtcttgaaa     8160

gg                                                                    8162


<210>  15
<211>  8162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP171 ; pHybE-hCg1,z,non-a V1

<400>  15
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgagc atttaaatgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcgt     2280

cgaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca     2340

cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga     2400

actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac     2460

tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca     2520

tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt gagcccaaat     2580

cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg gggggaccgt     2640

cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg     2700

tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc aactggtacg     2760

tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag tacaacagca     2820

cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt     2880

acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc atctccaaag     2940

ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgc gaggagatga     3000

ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc gacatcgccg     3060

tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct cccgtgctgg     3120

actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc aggtggcagc     3180

aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga     3240

agagcctctc cctgtctccg ggtaaatgag cggccgctcg aggccggcaa ggccggatcc     3300

cccgacctcg acctctggct aataaaggaa atttattttc attgcaatag tgtgttggaa     3360

ttttttgtgt ctctcactcg gaaggacata tgggagggca aatcatttgg tcgagatccc     3420

tcggagatct ctagctagag gatcgatccc cgccccggac gaactaaacc tgactacgac     3480

atctctgccc cttcttcgcg gggcagtgca tgtaatccct tcagttggtt ggtacaactt     3540

gccaactggg ccctgttcca catgtgacac ggggggggac caaacacaaa ggggttctct     3600

gactgtagtt gacatcctta taaatggatg tgcacatttg ccaacactga gtggctttca     3660

tcctggagca gactttgcag tctgtggact gcaacacaac attgccttta tgtgtaactc     3720

ttggctgaag ctcttacacc aatgctgggg gacatgtacc tcccaggggc ccaggaagac     3780

tacgggaggc tacaccaacg tcaatcagag gggcctgtgt agctaccgat aagcggaccc     3840

tcaagagggc attagcaata gtgtttataa ggcccccttg ttaaccctaa acgggtagca     3900

tatgcttccc gggtagtagt atatactatc cagactaacc ctaattcaat agcatatgtt     3960

acccaacggg aagcatatgc tatcgaatta gggttagtaa aagggtccta aggaacagcg     4020

atatctccca ccccatgagc tgtcacggtt ttatttacat ggggtcagga ttccacgagg     4080

gtagtgaacc attttagtca caagggcagt ggctgaagat caaggagcgg gcagtgaact     4140

ctcctgaatc ttcgcctgct tcttcattct ccttcgttta gctaatagaa taactgctga     4200

gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa ggtttcaggt gacgccccca     4260

gaataaaatt tggacggggg gttcagtggt ggcattgtgc tatgacacca atataaccct     4320

cacaaacccc ttgggcaata aatactagtg taggaatgaa acattctgaa tatctttaac     4380

aatagaaatc catggggtgg ggacaagccg taaagactgg atgtccatct cacacgaatt     4440

tatggctatg ggcaacacat aatcctagtg caatatgata ctggggttat taagatgtgt     4500

cccaggcagg gaccaagaca ggtgaaccat gttgttacac tctatttgta acaaggggaa     4560

agagagtgga cgccgacagc agcggactcc actggttgtc tctaacaccc ccgaaaatta     4620

aacggggctc cacgccaatg gggcccataa acaaagacaa gtggccactc ttttttttga     4680

aattgtggag tgggggcacg cgtcagcccc cacacgccgc cctgcggttt tggactgtaa     4740

aataagggtg taataacttg gctgattgta accccgctaa ccactgcggt caaaccactt     4800

gcccacaaaa ccactaatgg caccccgggg aatacctgca taagtaggtg ggcgggccaa     4860

gataggggcg cgattgctgc gatctggagg acaaattaca cacacttgcg cctgagcgcc     4920

aagcacaggg ttgttggtcc tcatattcac gaggtcgctg agagcacggt gggctaatgt     4980

tgccatgggt agcatatact acccaaatat ctggatagca tatgctatcc taatctatat     5040

ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat     5100

ctgggtagta tatgctatcc taatttatat ctgggtagca taggctatcc taatctatat     5160

ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc taatctgtat     5220

ccgggtagca tatgctatcc taatagagat tagggtagta tatgctatcc taatttatat     5280

ctgggtagca tatactaccc aaatatctgg atagcatatg ctatcctaat ctatatctgg     5340

gtagcatatg ctatcctaat ctatatctgg gtagcatagg ctatcctaat ctatatctgg     5400

gtagcatatg ctatcctaat ctatatctgg gtagtatatg ctatcctaat ttatatctgg     5460

gtagcatagg ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg     5520

gtagtatatg ctatcctaat ctgtatccgg gtagcatatg ctatcctcat gataagctgt     5580

caaacatgag aattttcttg aagacgaaag ggcctcgtga tacgcctatt tttataggtt     5640

aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc     5700

ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa     5760

taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc     5820

cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa     5880

acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa     5940

ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg     6000

atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtgttga cgccgggcaa     6060

gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc     6120

acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc     6180

atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta     6240

accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag     6300

ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgcagc aatggcaaca     6360

acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca acaattaata     6420

gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc     6480

tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca     6540

ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca     6600

actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg     6660

taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa     6720

tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt     6780

gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat     6840

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     6900

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     6960

gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac     7020

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     7080

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     7140

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     7200

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     7260

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     7320

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     7380

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     7440

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc     7500

cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc     7560

cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa     7620

ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac     7680

tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc     7740

caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa     7800

tttcacacag gaaacagcta tgaccatgat tacgccaagc tctagctaga ggtcgagtcc     7860

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc     7920

gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca     7980

tggctgacta atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt     8040

ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tttgcaaaga     8100

tggataaagt tttaaacaga gaggaatctt tgcagctaat ggaccttcta ggtcttgaaa     8160

gg                                                                    8162


<210>  16
<211>  8162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP183 ; pHybE-hCg1,z,non-a V2

<400>  16
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgaga tccattgtgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcgt     2280

cgaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca     2340

cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga     2400

actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac     2460

tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca     2520

tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt gagcccaaat     2580

cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg gggggaccgt     2640

cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg     2700

tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc aactggtacg     2760

tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag tacaacagca     2820

cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt     2880

acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc atctccaaag     2940

ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgc gaggagatga     3000

ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc gacatcgccg     3060

tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct cccgtgctgg     3120

actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc aggtggcagc     3180

aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga     3240

agagcctctc cctgtctccg ggtaaatgag cggccgctcg aggccggcaa ggccggatcc     3300

cccgacctcg acctctggct aataaaggaa atttattttc attgcaatag tgtgttggaa     3360

ttttttgtgt ctctcactcg gaaggacata tgggagggca aatcatttgg tcgagatccc     3420

tcggagatct ctagctagag gatcgatccc cgccccggac gaactaaacc tgactacgac     3480

atctctgccc cttcttcgcg gggcagtgca tgtaatccct tcagttggtt ggtacaactt     3540

gccaactggg ccctgttcca catgtgacac ggggggggac caaacacaaa ggggttctct     3600

gactgtagtt gacatcctta taaatggatg tgcacatttg ccaacactga gtggctttca     3660

tcctggagca gactttgcag tctgtggact gcaacacaac attgccttta tgtgtaactc     3720

ttggctgaag ctcttacacc aatgctgggg gacatgtacc tcccaggggc ccaggaagac     3780

tacgggaggc tacaccaacg tcaatcagag gggcctgtgt agctaccgat aagcggaccc     3840

tcaagagggc attagcaata gtgtttataa ggcccccttg ttaaccctaa acgggtagca     3900

tatgcttccc gggtagtagt atatactatc cagactaacc ctaattcaat agcatatgtt     3960

acccaacggg aagcatatgc tatcgaatta gggttagtaa aagggtccta aggaacagcg     4020

atatctccca ccccatgagc tgtcacggtt ttatttacat ggggtcagga ttccacgagg     4080

gtagtgaacc attttagtca caagggcagt ggctgaagat caaggagcgg gcagtgaact     4140

ctcctgaatc ttcgcctgct tcttcattct ccttcgttta gctaatagaa taactgctga     4200

gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa ggtttcaggt gacgccccca     4260

gaataaaatt tggacggggg gttcagtggt ggcattgtgc tatgacacca atataaccct     4320

cacaaacccc ttgggcaata aatactagtg taggaatgaa acattctgaa tatctttaac     4380

aatagaaatc catggggtgg ggacaagccg taaagactgg atgtccatct cacacgaatt     4440

tatggctatg ggcaacacat aatcctagtg caatatgata ctggggttat taagatgtgt     4500

cccaggcagg gaccaagaca ggtgaaccat gttgttacac tctatttgta acaaggggaa     4560

agagagtgga cgccgacagc agcggactcc actggttgtc tctaacaccc ccgaaaatta     4620

aacggggctc cacgccaatg gggcccataa acaaagacaa gtggccactc ttttttttga     4680

aattgtggag tgggggcacg cgtcagcccc cacacgccgc cctgcggttt tggactgtaa     4740

aataagggtg taataacttg gctgattgta accccgctaa ccactgcggt caaaccactt     4800

gcccacaaaa ccactaatgg caccccgggg aatacctgca taagtaggtg ggcgggccaa     4860

gataggggcg cgattgctgc gatctggagg acaaattaca cacacttgcg cctgagcgcc     4920

aagcacaggg ttgttggtcc tcatattcac gaggtcgctg agagcacggt gggctaatgt     4980

tgccatgggt agcatatact acccaaatat ctggatagca tatgctatcc taatctatat     5040

ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat     5100

ctgggtagta tatgctatcc taatttatat ctgggtagca taggctatcc taatctatat     5160

ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc taatctgtat     5220

ccgggtagca tatgctatcc taatagagat tagggtagta tatgctatcc taatttatat     5280

ctgggtagca tatactaccc aaatatctgg atagcatatg ctatcctaat ctatatctgg     5340

gtagcatatg ctatcctaat ctatatctgg gtagcatagg ctatcctaat ctatatctgg     5400

gtagcatatg ctatcctaat ctatatctgg gtagtatatg ctatcctaat ttatatctgg     5460

gtagcatagg ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg     5520

gtagtatatg ctatcctaat ctgtatccgg gtagcatatg ctatcctcat gataagctgt     5580

caaacatgag aattttcttg aagacgaaag ggcctcgtga tacgcctatt tttataggtt     5640

aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc     5700

ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa     5760

taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc     5820

cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa     5880

acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa     5940

ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg     6000

atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtgttga cgccgggcaa     6060

gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc     6120

acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc     6180

atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta     6240

accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag     6300

ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgcagc aatggcaaca     6360

acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca acaattaata     6420

gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc     6480

tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca     6540

ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca     6600

actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg     6660

taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa     6720

tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt     6780

gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat     6840

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     6900

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     6960

gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac     7020

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     7080

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     7140

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     7200

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     7260

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     7320

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     7380

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     7440

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc     7500

cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc     7560

cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa     7620

ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac     7680

tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc     7740

caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa     7800

tttcacacag gaaacagcta tgaccatgat tacgccaagc tctagctaga ggtcgagtcc     7860

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc     7920

gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca     7980

tggctgacta atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt     8040

ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tttgcaaaga     8100

tggataaagt tttaaacaga gaggaatctt tgcagctaat ggaccttcta ggtcttgaaa     8160

gg                                                                    8162


<210>  17
<211>  8162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP172 ; pHybE-hCg1,z,non-a,mut(234,235) V1

<400>  17
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgagc atttaaatgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcgt     2280

cgaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca     2340

cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga     2400

actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac     2460

tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca     2520

tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt gagcccaaat     2580

cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg gggggaccgt     2640

cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg     2700

tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc aactggtacg     2760

tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag tacaacagca     2820

cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt     2880

acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc atctccaaag     2940

ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgc gaggagatga     3000

ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc gacatcgccg     3060

tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct cccgtgctgg     3120

actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc aggtggcagc     3180

aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga     3240

agagcctctc cctgtctccg ggtaaatgag cggccgctcg aggccggcaa ggccggatcc     3300

cccgacctcg acctctggct aataaaggaa atttattttc attgcaatag tgtgttggaa     3360

ttttttgtgt ctctcactcg gaaggacata tgggagggca aatcatttgg tcgagatccc     3420

tcggagatct ctagctagag gatcgatccc cgccccggac gaactaaacc tgactacgac     3480

atctctgccc cttcttcgcg gggcagtgca tgtaatccct tcagttggtt ggtacaactt     3540

gccaactggg ccctgttcca catgtgacac ggggggggac caaacacaaa ggggttctct     3600

gactgtagtt gacatcctta taaatggatg tgcacatttg ccaacactga gtggctttca     3660

tcctggagca gactttgcag tctgtggact gcaacacaac attgccttta tgtgtaactc     3720

ttggctgaag ctcttacacc aatgctgggg gacatgtacc tcccaggggc ccaggaagac     3780

tacgggaggc tacaccaacg tcaatcagag gggcctgtgt agctaccgat aagcggaccc     3840

tcaagagggc attagcaata gtgtttataa ggcccccttg ttaaccctaa acgggtagca     3900

tatgcttccc gggtagtagt atatactatc cagactaacc ctaattcaat agcatatgtt     3960

acccaacggg aagcatatgc tatcgaatta gggttagtaa aagggtccta aggaacagcg     4020

atatctccca ccccatgagc tgtcacggtt ttatttacat ggggtcagga ttccacgagg     4080

gtagtgaacc attttagtca caagggcagt ggctgaagat caaggagcgg gcagtgaact     4140

ctcctgaatc ttcgcctgct tcttcattct ccttcgttta gctaatagaa taactgctga     4200

gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa ggtttcaggt gacgccccca     4260

gaataaaatt tggacggggg gttcagtggt ggcattgtgc tatgacacca atataaccct     4320

cacaaacccc ttgggcaata aatactagtg taggaatgaa acattctgaa tatctttaac     4380

aatagaaatc catggggtgg ggacaagccg taaagactgg atgtccatct cacacgaatt     4440

tatggctatg ggcaacacat aatcctagtg caatatgata ctggggttat taagatgtgt     4500

cccaggcagg gaccaagaca ggtgaaccat gttgttacac tctatttgta acaaggggaa     4560

agagagtgga cgccgacagc agcggactcc actggttgtc tctaacaccc ccgaaaatta     4620

aacggggctc cacgccaatg gggcccataa acaaagacaa gtggccactc ttttttttga     4680

aattgtggag tgggggcacg cgtcagcccc cacacgccgc cctgcggttt tggactgtaa     4740

aataagggtg taataacttg gctgattgta accccgctaa ccactgcggt caaaccactt     4800

gcccacaaaa ccactaatgg caccccgggg aatacctgca taagtaggtg ggcgggccaa     4860

gataggggcg cgattgctgc gatctggagg acaaattaca cacacttgcg cctgagcgcc     4920

aagcacaggg ttgttggtcc tcatattcac gaggtcgctg agagcacggt gggctaatgt     4980

tgccatgggt agcatatact acccaaatat ctggatagca tatgctatcc taatctatat     5040

ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat     5100

ctgggtagta tatgctatcc taatttatat ctgggtagca taggctatcc taatctatat     5160

ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc taatctgtat     5220

ccgggtagca tatgctatcc taatagagat tagggtagta tatgctatcc taatttatat     5280

ctgggtagca tatactaccc aaatatctgg atagcatatg ctatcctaat ctatatctgg     5340

gtagcatatg ctatcctaat ctatatctgg gtagcatagg ctatcctaat ctatatctgg     5400

gtagcatatg ctatcctaat ctatatctgg gtagtatatg ctatcctaat ttatatctgg     5460

gtagcatagg ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg     5520

gtagtatatg ctatcctaat ctgtatccgg gtagcatatg ctatcctcat gataagctgt     5580

caaacatgag aattttcttg aagacgaaag ggcctcgtga tacgcctatt tttataggtt     5640

aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc     5700

ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa     5760

taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc     5820

cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa     5880

acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa     5940

ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg     6000

atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtgttga cgccgggcaa     6060

gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc     6120

acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc     6180

atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta     6240

accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag     6300

ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgcagc aatggcaaca     6360

acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca acaattaata     6420

gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc     6480

tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca     6540

ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca     6600

actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg     6660

taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa     6720

tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt     6780

gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat     6840

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     6900

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     6960

gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac     7020

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     7080

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     7140

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     7200

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     7260

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     7320

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     7380

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     7440

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc     7500

cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc     7560

cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa     7620

ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac     7680

tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc     7740

caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa     7800

tttcacacag gaaacagcta tgaccatgat tacgccaagc tctagctaga ggtcgagtcc     7860

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc     7920

gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca     7980

tggctgacta atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt     8040

ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tttgcaaaga     8100

tggataaagt tttaaacaga gaggaatctt tgcagctaat ggaccttcta ggtcttgaaa     8160

gg                                                                    8162


<210>  18
<211>  8162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP184 ; pHybE-hCg1,z,non-a,mut(234,235) V2

<400>  18
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgaga tccattgtgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcgt     2280

cgaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca     2340

cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga     2400

actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac     2460

tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca     2520

tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt gagcccaaat     2580

cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg gggggaccgt     2640

cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg     2700

tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc aactggtacg     2760

tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag tacaacagca     2820

cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt     2880

acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc atctccaaag     2940

ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgc gaggagatga     3000

ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc gacatcgccg     3060

tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct cccgtgctgg     3120

actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc aggtggcagc     3180

aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga     3240

agagcctctc cctgtctccg ggtaaatgag cggccgctcg aggccggcaa ggccggatcc     3300

cccgacctcg acctctggct aataaaggaa atttattttc attgcaatag tgtgttggaa     3360

ttttttgtgt ctctcactcg gaaggacata tgggagggca aatcatttgg tcgagatccc     3420

tcggagatct ctagctagag gatcgatccc cgccccggac gaactaaacc tgactacgac     3480

atctctgccc cttcttcgcg gggcagtgca tgtaatccct tcagttggtt ggtacaactt     3540

gccaactggg ccctgttcca catgtgacac ggggggggac caaacacaaa ggggttctct     3600

gactgtagtt gacatcctta taaatggatg tgcacatttg ccaacactga gtggctttca     3660

tcctggagca gactttgcag tctgtggact gcaacacaac attgccttta tgtgtaactc     3720

ttggctgaag ctcttacacc aatgctgggg gacatgtacc tcccaggggc ccaggaagac     3780

tacgggaggc tacaccaacg tcaatcagag gggcctgtgt agctaccgat aagcggaccc     3840

tcaagagggc attagcaata gtgtttataa ggcccccttg ttaaccctaa acgggtagca     3900

tatgcttccc gggtagtagt atatactatc cagactaacc ctaattcaat agcatatgtt     3960

acccaacggg aagcatatgc tatcgaatta gggttagtaa aagggtccta aggaacagcg     4020

atatctccca ccccatgagc tgtcacggtt ttatttacat ggggtcagga ttccacgagg     4080

gtagtgaacc attttagtca caagggcagt ggctgaagat caaggagcgg gcagtgaact     4140

ctcctgaatc ttcgcctgct tcttcattct ccttcgttta gctaatagaa taactgctga     4200

gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa ggtttcaggt gacgccccca     4260

gaataaaatt tggacggggg gttcagtggt ggcattgtgc tatgacacca atataaccct     4320

cacaaacccc ttgggcaata aatactagtg taggaatgaa acattctgaa tatctttaac     4380

aatagaaatc catggggtgg ggacaagccg taaagactgg atgtccatct cacacgaatt     4440

tatggctatg ggcaacacat aatcctagtg caatatgata ctggggttat taagatgtgt     4500

cccaggcagg gaccaagaca ggtgaaccat gttgttacac tctatttgta acaaggggaa     4560

agagagtgga cgccgacagc agcggactcc actggttgtc tctaacaccc ccgaaaatta     4620

aacggggctc cacgccaatg gggcccataa acaaagacaa gtggccactc ttttttttga     4680

aattgtggag tgggggcacg cgtcagcccc cacacgccgc cctgcggttt tggactgtaa     4740

aataagggtg taataacttg gctgattgta accccgctaa ccactgcggt caaaccactt     4800

gcccacaaaa ccactaatgg caccccgggg aatacctgca taagtaggtg ggcgggccaa     4860

gataggggcg cgattgctgc gatctggagg acaaattaca cacacttgcg cctgagcgcc     4920

aagcacaggg ttgttggtcc tcatattcac gaggtcgctg agagcacggt gggctaatgt     4980

tgccatgggt agcatatact acccaaatat ctggatagca tatgctatcc taatctatat     5040

ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat     5100

ctgggtagta tatgctatcc taatttatat ctgggtagca taggctatcc taatctatat     5160

ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc taatctgtat     5220

ccgggtagca tatgctatcc taatagagat tagggtagta tatgctatcc taatttatat     5280

ctgggtagca tatactaccc aaatatctgg atagcatatg ctatcctaat ctatatctgg     5340

gtagcatatg ctatcctaat ctatatctgg gtagcatagg ctatcctaat ctatatctgg     5400

gtagcatatg ctatcctaat ctatatctgg gtagtatatg ctatcctaat ttatatctgg     5460

gtagcatagg ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg     5520

gtagtatatg ctatcctaat ctgtatccgg gtagcatatg ctatcctcat gataagctgt     5580

caaacatgag aattttcttg aagacgaaag ggcctcgtga tacgcctatt tttataggtt     5640

aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc     5700

ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa     5760

taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc     5820

cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa     5880

acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa     5940

ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg     6000

atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtgttga cgccgggcaa     6060

gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc     6120

acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc     6180

atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta     6240

accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag     6300

ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgcagc aatggcaaca     6360

acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca acaattaata     6420

gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc     6480

tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca     6540

ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca     6600

actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg     6660

taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa     6720

tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt     6780

gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat     6840

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     6900

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     6960

gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac     7020

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     7080

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     7140

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     7200

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     7260

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     7320

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     7380

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     7440

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc     7500

cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc     7560

cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa     7620

ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac     7680

tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc     7740

caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa     7800

tttcacacag gaaacagcta tgaccatgat tacgccaagc tctagctaga ggtcgagtcc     7860

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc     7920

gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca     7980

tggctgacta atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt     8040

ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tttgcaaaga     8100

tggataaagt tttaaacaga gaggaatctt tgcagctaat ggaccttcta ggtcttgaaa     8160

gg                                                                    8162


<210>  19
<211>  8162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP173 ; pHybE-hCg1,z,non-a,mut (234,237) V1

<400>  19
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgagc atttaaatgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcgt     2280

cgaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca     2340

cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga     2400

actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac     2460

tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca     2520

tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt gagcccaaat     2580

cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccctg ggggcaccgt     2640

cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg     2700

tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc aactggtacg     2760

tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag tacaacagca     2820

cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt     2880

acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc atctccaaag     2940

ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgc gaggagatga     3000

ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc gacatcgccg     3060

tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct cccgtgctgg     3120

actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc aggtggcagc     3180

aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga     3240

agagcctctc cctgtctccg ggtaaatgag cggccgctcg aggccggcaa ggccggatcc     3300

cccgacctcg acctctggct aataaaggaa atttattttc attgcaatag tgtgttggaa     3360

ttttttgtgt ctctcactcg gaaggacata tgggagggca aatcatttgg tcgagatccc     3420

tcggagatct ctagctagag gatcgatccc cgccccggac gaactaaacc tgactacgac     3480

atctctgccc cttcttcgcg gggcagtgca tgtaatccct tcagttggtt ggtacaactt     3540

gccaactggg ccctgttcca catgtgacac ggggggggac caaacacaaa ggggttctct     3600

gactgtagtt gacatcctta taaatggatg tgcacatttg ccaacactga gtggctttca     3660

tcctggagca gactttgcag tctgtggact gcaacacaac attgccttta tgtgtaactc     3720

ttggctgaag ctcttacacc aatgctgggg gacatgtacc tcccaggggc ccaggaagac     3780

tacgggaggc tacaccaacg tcaatcagag gggcctgtgt agctaccgat aagcggaccc     3840

tcaagagggc attagcaata gtgtttataa ggcccccttg ttaaccctaa acgggtagca     3900

tatgcttccc gggtagtagt atatactatc cagactaacc ctaattcaat agcatatgtt     3960

acccaacggg aagcatatgc tatcgaatta gggttagtaa aagggtccta aggaacagcg     4020

atatctccca ccccatgagc tgtcacggtt ttatttacat ggggtcagga ttccacgagg     4080

gtagtgaacc attttagtca caagggcagt ggctgaagat caaggagcgg gcagtgaact     4140

ctcctgaatc ttcgcctgct tcttcattct ccttcgttta gctaatagaa taactgctga     4200

gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa ggtttcaggt gacgccccca     4260

gaataaaatt tggacggggg gttcagtggt ggcattgtgc tatgacacca atataaccct     4320

cacaaacccc ttgggcaata aatactagtg taggaatgaa acattctgaa tatctttaac     4380

aatagaaatc catggggtgg ggacaagccg taaagactgg atgtccatct cacacgaatt     4440

tatggctatg ggcaacacat aatcctagtg caatatgata ctggggttat taagatgtgt     4500

cccaggcagg gaccaagaca ggtgaaccat gttgttacac tctatttgta acaaggggaa     4560

agagagtgga cgccgacagc agcggactcc actggttgtc tctaacaccc ccgaaaatta     4620

aacggggctc cacgccaatg gggcccataa acaaagacaa gtggccactc ttttttttga     4680

aattgtggag tgggggcacg cgtcagcccc cacacgccgc cctgcggttt tggactgtaa     4740

aataagggtg taataacttg gctgattgta accccgctaa ccactgcggt caaaccactt     4800

gcccacaaaa ccactaatgg caccccgggg aatacctgca taagtaggtg ggcgggccaa     4860

gataggggcg cgattgctgc gatctggagg acaaattaca cacacttgcg cctgagcgcc     4920

aagcacaggg ttgttggtcc tcatattcac gaggtcgctg agagcacggt gggctaatgt     4980

tgccatgggt agcatatact acccaaatat ctggatagca tatgctatcc taatctatat     5040

ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat     5100

ctgggtagta tatgctatcc taatttatat ctgggtagca taggctatcc taatctatat     5160

ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc taatctgtat     5220

ccgggtagca tatgctatcc taatagagat tagggtagta tatgctatcc taatttatat     5280

ctgggtagca tatactaccc aaatatctgg atagcatatg ctatcctaat ctatatctgg     5340

gtagcatatg ctatcctaat ctatatctgg gtagcatagg ctatcctaat ctatatctgg     5400

gtagcatatg ctatcctaat ctatatctgg gtagtatatg ctatcctaat ttatatctgg     5460

gtagcatagg ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg     5520

gtagtatatg ctatcctaat ctgtatccgg gtagcatatg ctatcctcat gataagctgt     5580

caaacatgag aattttcttg aagacgaaag ggcctcgtga tacgcctatt tttataggtt     5640

aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc     5700

ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa     5760

taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc     5820

cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa     5880

acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa     5940

ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg     6000

atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtgttga cgccgggcaa     6060

gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc     6120

acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc     6180

atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta     6240

accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag     6300

ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgcagc aatggcaaca     6360

acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca acaattaata     6420

gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc     6480

tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca     6540

ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca     6600

actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg     6660

taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa     6720

tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt     6780

gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat     6840

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     6900

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     6960

gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac     7020

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     7080

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     7140

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     7200

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     7260

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     7320

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     7380

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     7440

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc     7500

cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc     7560

cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa     7620

ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac     7680

tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc     7740

caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa     7800

tttcacacag gaaacagcta tgaccatgat tacgccaagc tctagctaga ggtcgagtcc     7860

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc     7920

gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca     7980

tggctgacta atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt     8040

ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tttgcaaaga     8100

tggataaagt tttaaacaga gaggaatctt tgcagctaat ggaccttcta ggtcttgaaa     8160

gg                                                                    8162


<210>  20
<211>  8162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP185 ; pHybE-hCg1,z,non-a,mut (234,237) V2

<400>  20
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgaga tccattgtgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcgt     2280

cgaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca     2340

cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga     2400

actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac     2460

tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca     2520

tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt gagcccaaat     2580

cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccctg ggggcaccgt     2640

cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg     2700

tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc aactggtacg     2760

tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag tacaacagca     2820

cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt     2880

acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc atctccaaag     2940

ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgc gaggagatga     3000

ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc gacatcgccg     3060

tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct cccgtgctgg     3120

actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc aggtggcagc     3180

aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga     3240

agagcctctc cctgtctccg ggtaaatgag cggccgctcg aggccggcaa ggccggatcc     3300

cccgacctcg acctctggct aataaaggaa atttattttc attgcaatag tgtgttggaa     3360

ttttttgtgt ctctcactcg gaaggacata tgggagggca aatcatttgg tcgagatccc     3420

tcggagatct ctagctagag gatcgatccc cgccccggac gaactaaacc tgactacgac     3480

atctctgccc cttcttcgcg gggcagtgca tgtaatccct tcagttggtt ggtacaactt     3540

gccaactggg ccctgttcca catgtgacac ggggggggac caaacacaaa ggggttctct     3600

gactgtagtt gacatcctta taaatggatg tgcacatttg ccaacactga gtggctttca     3660

tcctggagca gactttgcag tctgtggact gcaacacaac attgccttta tgtgtaactc     3720

ttggctgaag ctcttacacc aatgctgggg gacatgtacc tcccaggggc ccaggaagac     3780

tacgggaggc tacaccaacg tcaatcagag gggcctgtgt agctaccgat aagcggaccc     3840

tcaagagggc attagcaata gtgtttataa ggcccccttg ttaaccctaa acgggtagca     3900

tatgcttccc gggtagtagt atatactatc cagactaacc ctaattcaat agcatatgtt     3960

acccaacggg aagcatatgc tatcgaatta gggttagtaa aagggtccta aggaacagcg     4020

atatctccca ccccatgagc tgtcacggtt ttatttacat ggggtcagga ttccacgagg     4080

gtagtgaacc attttagtca caagggcagt ggctgaagat caaggagcgg gcagtgaact     4140

ctcctgaatc ttcgcctgct tcttcattct ccttcgttta gctaatagaa taactgctga     4200

gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa ggtttcaggt gacgccccca     4260

gaataaaatt tggacggggg gttcagtggt ggcattgtgc tatgacacca atataaccct     4320

cacaaacccc ttgggcaata aatactagtg taggaatgaa acattctgaa tatctttaac     4380

aatagaaatc catggggtgg ggacaagccg taaagactgg atgtccatct cacacgaatt     4440

tatggctatg ggcaacacat aatcctagtg caatatgata ctggggttat taagatgtgt     4500

cccaggcagg gaccaagaca ggtgaaccat gttgttacac tctatttgta acaaggggaa     4560

agagagtgga cgccgacagc agcggactcc actggttgtc tctaacaccc ccgaaaatta     4620

aacggggctc cacgccaatg gggcccataa acaaagacaa gtggccactc ttttttttga     4680

aattgtggag tgggggcacg cgtcagcccc cacacgccgc cctgcggttt tggactgtaa     4740

aataagggtg taataacttg gctgattgta accccgctaa ccactgcggt caaaccactt     4800

gcccacaaaa ccactaatgg caccccgggg aatacctgca taagtaggtg ggcgggccaa     4860

gataggggcg cgattgctgc gatctggagg acaaattaca cacacttgcg cctgagcgcc     4920

aagcacaggg ttgttggtcc tcatattcac gaggtcgctg agagcacggt gggctaatgt     4980

tgccatgggt agcatatact acccaaatat ctggatagca tatgctatcc taatctatat     5040

ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat     5100

ctgggtagta tatgctatcc taatttatat ctgggtagca taggctatcc taatctatat     5160

ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc taatctgtat     5220

ccgggtagca tatgctatcc taatagagat tagggtagta tatgctatcc taatttatat     5280

ctgggtagca tatactaccc aaatatctgg atagcatatg ctatcctaat ctatatctgg     5340

gtagcatatg ctatcctaat ctatatctgg gtagcatagg ctatcctaat ctatatctgg     5400

gtagcatatg ctatcctaat ctatatctgg gtagtatatg ctatcctaat ttatatctgg     5460

gtagcatagg ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg     5520

gtagtatatg ctatcctaat ctgtatccgg gtagcatatg ctatcctcat gataagctgt     5580

caaacatgag aattttcttg aagacgaaag ggcctcgtga tacgcctatt tttataggtt     5640

aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc     5700

ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa     5760

taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc     5820

cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa     5880

acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg ttacatcgaa     5940

ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ttttccaatg     6000

atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtgttga cgccgggcaa     6060

gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ctcaccagtc     6120

acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc     6180

atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc gaaggagcta     6240

accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag     6300

ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgcagc aatggcaaca     6360

acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca acaattaata     6420

gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc     6480

tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca     6540

ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca     6600

actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg     6660

taactgtcag accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa     6720

tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt     6780

gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat     6840

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     6900

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     6960

gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac     7020

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     7080

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     7140

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     7200

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     7260

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     7320

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     7380

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     7440

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc     7500

cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc     7560

cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa     7620

ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac     7680

tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc     7740

caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa     7800

tttcacacag gaaacagcta tgaccatgat tacgccaagc tctagctaga ggtcgagtcc     7860

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc     7920

gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca     7980

tggctgacta atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt     8040

ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tttgcaaaga     8100

tggataaagt tttaaacaga gaggaatctt tgcagctaat ggaccttcta ggtcttgaaa     8160

gg                                                                    8162


<210>  21
<211>  8151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP174 ; pHybE-hCg2,n- V1

<400>  21
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgagc atttaaatgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcgt     2280

cgaccaaggg cccatcggtc ttccccctgg cgccctgctc tagaagcacc tccgagagca     2340

cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga     2400

actcaggcgc tctgaccagc ggcgtgcaca ccttcccagc tgtcctgcag tcctcaggac     2460

tctactccct cagcagcgtg gtgaccgtgc cctccagcaa cttcggcacc cagacctaca     2520

catgcaacgt agatcacaag cccagcaaca ccaaggtgga caagacagtt gagcgcaaat     2580

gttgtgtcga gtgcccaccg tgcccagcac cacctgtggc aggaccgtca gtcttcctct     2640

tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc acgtgcgtgg     2700

tggtggacgt gagccacgaa gaccccgagg tccagttcaa ctggtacgtg gacggcgtgg     2760

aggtgcataa tgccaagaca aagccacggg aggagcagtt caacagcacg ttccgtgtgg     2820

tcagcgtcct caccgttgtg caccaggact ggctgaacgg caaggagtac aagtgcaagg     2880

tctccaacaa aggcctccca gcccccatcg agaaaaccat ctccaaaacc aaagggcagc     2940

cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc aagaaccagg     3000

tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg gagtgggaga     3060

gcaatgggca gccggagaac aactacaaga ccacacctcc catgctggac tccgacggct     3120

ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct     3180

tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc     3240

tgtctccggg taaatgacgc ggccgctcga ggccggcaag gccggatccc ccgacctcga     3300

cctctggcta ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc     3360

tctcactcgg aaggacatat gggagggcaa atcatttggt cgagatccct cggagatctc     3420

tagctagagg atcgatcccc gccccggacg aactaaacct gactacgaca tctctgcccc     3480

ttcttcgcgg ggcagtgcat gtaatccctt cagttggttg gtacaacttg ccaactgggc     3540

cctgttccac atgtgacacg gggggggacc aaacacaaag gggttctctg actgtagttg     3600

acatccttat aaatggatgt gcacatttgc caacactgag tggctttcat cctggagcag     3660

actttgcagt ctgtggactg caacacaaca ttgcctttat gtgtaactct tggctgaagc     3720

tcttacacca atgctggggg acatgtacct cccaggggcc caggaagact acgggaggct     3780

acaccaacgt caatcagagg ggcctgtgta gctaccgata agcggaccct caagagggca     3840

ttagcaatag tgtttataag gcccccttgt taaccctaaa cgggtagcat atgcttcccg     3900

ggtagtagta tatactatcc agactaaccc taattcaata gcatatgtta cccaacggga     3960

agcatatgct atcgaattag ggttagtaaa agggtcctaa ggaacagcga tatctcccac     4020

cccatgagct gtcacggttt tatttacatg gggtcaggat tccacgaggg tagtgaacca     4080

ttttagtcac aagggcagtg gctgaagatc aaggagcggg cagtgaactc tcctgaatct     4140

tcgcctgctt cttcattctc cttcgtttag ctaatagaat aactgctgag ttgtgaacag     4200

taaggtgtat gtgaggtgct cgaaaacaag gtttcaggtg acgcccccag aataaaattt     4260

ggacgggggg ttcagtggtg gcattgtgct atgacaccaa tataaccctc acaaacccct     4320

tgggcaataa atactagtgt aggaatgaaa cattctgaat atctttaaca atagaaatcc     4380

atggggtggg gacaagccgt aaagactgga tgtccatctc acacgaattt atggctatgg     4440

gcaacacata atcctagtgc aatatgatac tggggttatt aagatgtgtc ccaggcaggg     4500

accaagacag gtgaaccatg ttgttacact ctatttgtaa caaggggaaa gagagtggac     4560

gccgacagca gcggactcca ctggttgtct ctaacacccc cgaaaattaa acggggctcc     4620

acgccaatgg ggcccataaa caaagacaag tggccactct tttttttgaa attgtggagt     4680

gggggcacgc gtcagccccc acacgccgcc ctgcggtttt ggactgtaaa ataagggtgt     4740

aataacttgg ctgattgtaa ccccgctaac cactgcggtc aaaccacttg cccacaaaac     4800

cactaatggc accccgggga atacctgcat aagtaggtgg gcgggccaag ataggggcgc     4860

gattgctgcg atctggagga caaattacac acacttgcgc ctgagcgcca agcacagggt     4920

tgttggtcct catattcacg aggtcgctga gagcacggtg ggctaatgtt gccatgggta     4980

gcatatacta cccaaatatc tggatagcat atgctatcct aatctatatc tgggtagcat     5040

aggctatcct aatctatatc tgggtagcat atgctatcct aatctatatc tgggtagtat     5100

atgctatcct aatttatatc tgggtagcat aggctatcct aatctatatc tgggtagcat     5160

atgctatcct aatctatatc tgggtagtat atgctatcct aatctgtatc cgggtagcat     5220

atgctatcct aatagagatt agggtagtat atgctatcct aatttatatc tgggtagcat     5280

atactaccca aatatctgga tagcatatgc tatcctaatc tatatctggg tagcatatgc     5340

tatcctaatc tatatctggg tagcataggc tatcctaatc tatatctggg tagcatatgc     5400

tatcctaatc tatatctggg tagtatatgc tatcctaatt tatatctggg tagcataggc     5460

tatcctaatc tatatctggg tagcatatgc tatcctaatc tatatctggg tagtatatgc     5520

tatcctaatc tgtatccggg tagcatatgc tatcctcatg ataagctgtc aaacatgaga     5580

attttcttga agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     5640

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     5700

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     5760

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     5820

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     5880

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     5940

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     6000

taaagttctg ctatgtggcg cggtattatc ccgtgttgac gccgggcaag agcaactcgg     6060

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     6120

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     6180

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     6240

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     6300

cataccaaac gacgagcgtg acaccacgat gcctgcagca atggcaacaa cgttgcgcaa     6360

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     6420

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     6480

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     6540

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     6600

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     6660

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     6720

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     6780

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     6840

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     6900

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     6960

aaatactgtt cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     7020

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     7080

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     7140

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     7200

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     7260

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     7320

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     7380

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     7440

cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt     7500

ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga     7560

gcgcagcgag tcagtgagcg aggaagcgga agagcgccca atacgcaaac cgcctctccc     7620

cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg tttcccgact ggaaagcggg     7680

cagtgagcgc aacgcaatta atgtgagtta gctcactcat taggcacccc aggctttaca     7740

ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc ggataacaat ttcacacagg     7800

aaacagctat gaccatgatt acgccaagct ctagctagag gtcgagtccc tccccagcag     7860

gcagaagtat gcaaagcatg catctcaatt agtcagcaac catagtcccg cccctaactc     7920

cgcccatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa     7980

ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc cagaagtagt     8040

gaggaggctt ttttggaggc ctaggctttt gcaaaaagct ttgcaaagat ggataaagtt     8100

ttaaacagag aggaatcttt gcagctaatg gaccttctag gtcttgaaag g              8151


<210>  22
<211>  8151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP187 ; pHybE-hCg2,n- V2

<400>  22
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgaga tccattgtgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcgt     2280

cgaccaaggg cccatcggtc ttccccctgg cgccctgctc tagaagcacc tccgagagca     2340

cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga     2400

actcaggcgc tctgaccagc ggcgtgcaca ccttcccagc tgtcctgcag tcctcaggac     2460

tctactccct cagcagcgtg gtgaccgtgc cctccagcaa cttcggcacc cagacctaca     2520

catgcaacgt agatcacaag cccagcaaca ccaaggtgga caagacagtt gagcgcaaat     2580

gttgtgtcga gtgcccaccg tgcccagcac cacctgtggc aggaccgtca gtcttcctct     2640

tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc acgtgcgtgg     2700

tggtggacgt gagccacgaa gaccccgagg tccagttcaa ctggtacgtg gacggcgtgg     2760

aggtgcataa tgccaagaca aagccacggg aggagcagtt caacagcacg ttccgtgtgg     2820

tcagcgtcct caccgttgtg caccaggact ggctgaacgg caaggagtac aagtgcaagg     2880

tctccaacaa aggcctccca gcccccatcg agaaaaccat ctccaaaacc aaagggcagc     2940

cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc aagaaccagg     3000

tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg gagtgggaga     3060

gcaatgggca gccggagaac aactacaaga ccacacctcc catgctggac tccgacggct     3120

ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct     3180

tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc     3240

tgtctccggg taaatgacgc ggccgctcga ggccggcaag gccggatccc ccgacctcga     3300

cctctggcta ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc     3360

tctcactcgg aaggacatat gggagggcaa atcatttggt cgagatccct cggagatctc     3420

tagctagagg atcgatcccc gccccggacg aactaaacct gactacgaca tctctgcccc     3480

ttcttcgcgg ggcagtgcat gtaatccctt cagttggttg gtacaacttg ccaactgggc     3540

cctgttccac atgtgacacg gggggggacc aaacacaaag gggttctctg actgtagttg     3600

acatccttat aaatggatgt gcacatttgc caacactgag tggctttcat cctggagcag     3660

actttgcagt ctgtggactg caacacaaca ttgcctttat gtgtaactct tggctgaagc     3720

tcttacacca atgctggggg acatgtacct cccaggggcc caggaagact acgggaggct     3780

acaccaacgt caatcagagg ggcctgtgta gctaccgata agcggaccct caagagggca     3840

ttagcaatag tgtttataag gcccccttgt taaccctaaa cgggtagcat atgcttcccg     3900

ggtagtagta tatactatcc agactaaccc taattcaata gcatatgtta cccaacggga     3960

agcatatgct atcgaattag ggttagtaaa agggtcctaa ggaacagcga tatctcccac     4020

cccatgagct gtcacggttt tatttacatg gggtcaggat tccacgaggg tagtgaacca     4080

ttttagtcac aagggcagtg gctgaagatc aaggagcggg cagtgaactc tcctgaatct     4140

tcgcctgctt cttcattctc cttcgtttag ctaatagaat aactgctgag ttgtgaacag     4200

taaggtgtat gtgaggtgct cgaaaacaag gtttcaggtg acgcccccag aataaaattt     4260

ggacgggggg ttcagtggtg gcattgtgct atgacaccaa tataaccctc acaaacccct     4320

tgggcaataa atactagtgt aggaatgaaa cattctgaat atctttaaca atagaaatcc     4380

atggggtggg gacaagccgt aaagactgga tgtccatctc acacgaattt atggctatgg     4440

gcaacacata atcctagtgc aatatgatac tggggttatt aagatgtgtc ccaggcaggg     4500

accaagacag gtgaaccatg ttgttacact ctatttgtaa caaggggaaa gagagtggac     4560

gccgacagca gcggactcca ctggttgtct ctaacacccc cgaaaattaa acggggctcc     4620

acgccaatgg ggcccataaa caaagacaag tggccactct tttttttgaa attgtggagt     4680

gggggcacgc gtcagccccc acacgccgcc ctgcggtttt ggactgtaaa ataagggtgt     4740

aataacttgg ctgattgtaa ccccgctaac cactgcggtc aaaccacttg cccacaaaac     4800

cactaatggc accccgggga atacctgcat aagtaggtgg gcgggccaag ataggggcgc     4860

gattgctgcg atctggagga caaattacac acacttgcgc ctgagcgcca agcacagggt     4920

tgttggtcct catattcacg aggtcgctga gagcacggtg ggctaatgtt gccatgggta     4980

gcatatacta cccaaatatc tggatagcat atgctatcct aatctatatc tgggtagcat     5040

aggctatcct aatctatatc tgggtagcat atgctatcct aatctatatc tgggtagtat     5100

atgctatcct aatttatatc tgggtagcat aggctatcct aatctatatc tgggtagcat     5160

atgctatcct aatctatatc tgggtagtat atgctatcct aatctgtatc cgggtagcat     5220

atgctatcct aatagagatt agggtagtat atgctatcct aatttatatc tgggtagcat     5280

atactaccca aatatctgga tagcatatgc tatcctaatc tatatctggg tagcatatgc     5340

tatcctaatc tatatctggg tagcataggc tatcctaatc tatatctggg tagcatatgc     5400

tatcctaatc tatatctggg tagtatatgc tatcctaatt tatatctggg tagcataggc     5460

tatcctaatc tatatctggg tagcatatgc tatcctaatc tatatctggg tagtatatgc     5520

tatcctaatc tgtatccggg tagcatatgc tatcctcatg ataagctgtc aaacatgaga     5580

attttcttga agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     5640

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     5700

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     5760

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     5820

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     5880

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     5940

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     6000

taaagttctg ctatgtggcg cggtattatc ccgtgttgac gccgggcaag agcaactcgg     6060

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     6120

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     6180

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     6240

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     6300

cataccaaac gacgagcgtg acaccacgat gcctgcagca atggcaacaa cgttgcgcaa     6360

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     6420

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     6480

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     6540

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     6600

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     6660

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     6720

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     6780

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     6840

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     6900

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     6960

aaatactgtt cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     7020

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     7080

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     7140

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     7200

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     7260

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     7320

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     7380

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     7440

cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt     7500

ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga     7560

gcgcagcgag tcagtgagcg aggaagcgga agagcgccca atacgcaaac cgcctctccc     7620

cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg tttcccgact ggaaagcggg     7680

cagtgagcgc aacgcaatta atgtgagtta gctcactcat taggcacccc aggctttaca     7740

ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc ggataacaat ttcacacagg     7800

aaacagctat gaccatgatt acgccaagct ctagctagag gtcgagtccc tccccagcag     7860

gcagaagtat gcaaagcatg catctcaatt agtcagcaac catagtcccg cccctaactc     7920

cgcccatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa     7980

ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc cagaagtagt     8040

gaggaggctt ttttggaggc ctaggctttt gcaaaaagct ttgcaaagat ggataaagtt     8100

ttaaacagag aggaatcttt gcagctaatg gaccttctag gtcttgaaag g              8151


<210>  23
<211>  8151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP181 ; pHybE-hCg2,n+ V1

<400>  23
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgagc atttaaatgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcgt     2280

cgaccaaggg cccatcggtc ttccccctgg cgccctgctc tagaagcacc tccgagagca     2340

cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga     2400

actcaggcgc tctgaccagc ggcgtgcaca ccttcccagc tgtcctgcag tcctcaggac     2460

tctactccct cagcagcgtg gtgaccgtga cctccagcaa cttcggcacc cagacctaca     2520

catgcaacgt agatcacaag cccagcaaca ccaaggtgga caagacagtt gagcgcaaat     2580

gttgtgtcga gtgcccaccg tgcccagcac cacctgtggc aggaccgtca gtcttcctct     2640

tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc acgtgcgtgg     2700

tggtggacgt gagccacgaa gaccccgagg tccagttcaa ctggtacgtg gacggcatgg     2760

aggtgcataa tgccaagaca aagccacggg aggagcagtt caacagcacg ttccgtgtgg     2820

tcagcgtcct caccgttgtg caccaggact ggctgaacgg caaggagtac aagtgcaagg     2880

tctccaacaa aggcctccca gcccccatcg agaaaaccat ctccaaaacc aaagggcagc     2940

cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc aagaaccagg     3000

tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg gagtgggaga     3060

gcaatgggca gccggagaac aactacaaga ccacacctcc catgctggac tccgacggct     3120

ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct     3180

tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc     3240

tgtctccggg taaatgacgc ggccgctcga ggccggcaag gccggatccc ccgacctcga     3300

cctctggcta ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc     3360

tctcactcgg aaggacatat gggagggcaa atcatttggt cgagatccct cggagatctc     3420

tagctagagg atcgatcccc gccccggacg aactaaacct gactacgaca tctctgcccc     3480

ttcttcgcgg ggcagtgcat gtaatccctt cagttggttg gtacaacttg ccaactgggc     3540

cctgttccac atgtgacacg gggggggacc aaacacaaag gggttctctg actgtagttg     3600

acatccttat aaatggatgt gcacatttgc caacactgag tggctttcat cctggagcag     3660

actttgcagt ctgtggactg caacacaaca ttgcctttat gtgtaactct tggctgaagc     3720

tcttacacca atgctggggg acatgtacct cccaggggcc caggaagact acgggaggct     3780

acaccaacgt caatcagagg ggcctgtgta gctaccgata agcggaccct caagagggca     3840

ttagcaatag tgtttataag gcccccttgt taaccctaaa cgggtagcat atgcttcccg     3900

ggtagtagta tatactatcc agactaaccc taattcaata gcatatgtta cccaacggga     3960

agcatatgct atcgaattag ggttagtaaa agggtcctaa ggaacagcga tatctcccac     4020

cccatgagct gtcacggttt tatttacatg gggtcaggat tccacgaggg tagtgaacca     4080

ttttagtcac aagggcagtg gctgaagatc aaggagcggg cagtgaactc tcctgaatct     4140

tcgcctgctt cttcattctc cttcgtttag ctaatagaat aactgctgag ttgtgaacag     4200

taaggtgtat gtgaggtgct cgaaaacaag gtttcaggtg acgcccccag aataaaattt     4260

ggacgggggg ttcagtggtg gcattgtgct atgacaccaa tataaccctc acaaacccct     4320

tgggcaataa atactagtgt aggaatgaaa cattctgaat atctttaaca atagaaatcc     4380

atggggtggg gacaagccgt aaagactgga tgtccatctc acacgaattt atggctatgg     4440

gcaacacata atcctagtgc aatatgatac tggggttatt aagatgtgtc ccaggcaggg     4500

accaagacag gtgaaccatg ttgttacact ctatttgtaa caaggggaaa gagagtggac     4560

gccgacagca gcggactcca ctggttgtct ctaacacccc cgaaaattaa acggggctcc     4620

acgccaatgg ggcccataaa caaagacaag tggccactct tttttttgaa attgtggagt     4680

gggggcacgc gtcagccccc acacgccgcc ctgcggtttt ggactgtaaa ataagggtgt     4740

aataacttgg ctgattgtaa ccccgctaac cactgcggtc aaaccacttg cccacaaaac     4800

cactaatggc accccgggga atacctgcat aagtaggtgg gcgggccaag ataggggcgc     4860

gattgctgcg atctggagga caaattacac acacttgcgc ctgagcgcca agcacagggt     4920

tgttggtcct catattcacg aggtcgctga gagcacggtg ggctaatgtt gccatgggta     4980

gcatatacta cccaaatatc tggatagcat atgctatcct aatctatatc tgggtagcat     5040

aggctatcct aatctatatc tgggtagcat atgctatcct aatctatatc tgggtagtat     5100

atgctatcct aatttatatc tgggtagcat aggctatcct aatctatatc tgggtagcat     5160

atgctatcct aatctatatc tgggtagtat atgctatcct aatctgtatc cgggtagcat     5220

atgctatcct aatagagatt agggtagtat atgctatcct aatttatatc tgggtagcat     5280

atactaccca aatatctgga tagcatatgc tatcctaatc tatatctggg tagcatatgc     5340

tatcctaatc tatatctggg tagcataggc tatcctaatc tatatctggg tagcatatgc     5400

tatcctaatc tatatctggg tagtatatgc tatcctaatt tatatctggg tagcataggc     5460

tatcctaatc tatatctggg tagcatatgc tatcctaatc tatatctggg tagtatatgc     5520

tatcctaatc tgtatccggg tagcatatgc tatcctcatg ataagctgtc aaacatgaga     5580

attttcttga agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     5640

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     5700

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     5760

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     5820

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     5880

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     5940

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     6000

taaagttctg ctatgtggcg cggtattatc ccgtgttgac gccgggcaag agcaactcgg     6060

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     6120

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     6180

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     6240

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     6300

cataccaaac gacgagcgtg acaccacgat gcctgcagca atggcaacaa cgttgcgcaa     6360

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     6420

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     6480

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     6540

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     6600

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     6660

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     6720

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     6780

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     6840

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     6900

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     6960

aaatactgtt cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     7020

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     7080

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     7140

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     7200

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     7260

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     7320

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     7380

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     7440

cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt     7500

ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga     7560

gcgcagcgag tcagtgagcg aggaagcgga agagcgccca atacgcaaac cgcctctccc     7620

cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg tttcccgact ggaaagcggg     7680

cagtgagcgc aacgcaatta atgtgagtta gctcactcat taggcacccc aggctttaca     7740

ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc ggataacaat ttcacacagg     7800

aaacagctat gaccatgatt acgccaagct ctagctagag gtcgagtccc tccccagcag     7860

gcagaagtat gcaaagcatg catctcaatt agtcagcaac catagtcccg cccctaactc     7920

cgcccatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa     7980

ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc cagaagtagt     8040

gaggaggctt ttttggaggc ctaggctttt gcaaaaagct ttgcaaagat ggataaagtt     8100

ttaaacagag aggaatcttt gcagctaatg gaccttctag gtcttgaaag g              8151


<210>  24
<211>  8151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP186 ; pHybE-hCg2,n+ V2

<400>  24
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgaga tccattgtgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcgt     2280

cgaccaaggg cccatcggtc ttccccctgg cgccctgctc tagaagcacc tccgagagca     2340

cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga     2400

actcaggcgc tctgaccagc ggcgtgcaca ccttcccagc tgtcctacag tcctcaggac     2460

tctactccct cagcagcgtg gtgaccgtaa cctccagcaa cttcggcacc cagacctaca     2520

catgcaacgt agatcacaag cccagcaaca ccaaggtgga caagacagtt gagcgcaaat     2580

gttgtgtcga gtgcccaccg tgcccagcac cacctgtggc aggaccgtca gtcttcctct     2640

tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc acgtgcgtgg     2700

tggtggacgt gagccacgaa gaccccgagg tccagttcaa ctggtacgtg gacggcatgg     2760

aggtgcataa tgccaagaca aagccacggg aggagcagtt caacagcacg ttccgtgtgg     2820

tcagcgtcct caccgttgtg caccaggact ggctgaacgg caaggagtac aagtgcaagg     2880

tctccaacaa aggcctccca gcccccatcg agaaaaccat ctccaaaacc aaagggcagc     2940

cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc aagaaccagg     3000

tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg gagtgggaga     3060

gcaatgggca gccggagaac aactacaaga ccacacctcc catgctggac tccgacggct     3120

ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct     3180

tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc     3240

tgtctccggg taaatgacgc ggccgctcga ggccggcaag gccggatccc ccgacctcga     3300

cctctggcta ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc     3360

tctcactcgg aaggacatat gggagggcaa atcatttggt cgagatccct cggagatctc     3420

tagctagagg atcgatcccc gccccggacg aactaaacct gactacgaca tctctgcccc     3480

ttcttcgcgg ggcagtgcat gtaatccctt cagttggttg gtacaacttg ccaactgggc     3540

cctgttccac atgtgacacg gggggggacc aaacacaaag gggttctctg actgtagttg     3600

acatccttat aaatggatgt gcacatttgc caacactgag tggctttcat cctggagcag     3660

actttgcagt ctgtggactg caacacaaca ttgcctttat gtgtaactct tggctgaagc     3720

tcttacacca atgctggggg acatgtacct cccaggggcc caggaagact acgggaggct     3780

acaccaacgt caatcagagg ggcctgtgta gctaccgata agcggaccct caagagggca     3840

ttagcaatag tgtttataag gcccccttgt taaccctaaa cgggtagcat atgcttcccg     3900

ggtagtagta tatactatcc agactaaccc taattcaata gcatatgtta cccaacggga     3960

agcatatgct atcgaattag ggttagtaaa agggtcctaa ggaacagcga tatctcccac     4020

cccatgagct gtcacggttt tatttacatg gggtcaggat tccacgaggg tagtgaacca     4080

ttttagtcac aagggcagtg gctgaagatc aaggagcggg cagtgaactc tcctgaatct     4140

tcgcctgctt cttcattctc cttcgtttag ctaatagaat aactgctgag ttgtgaacag     4200

taaggtgtat gtgaggtgct cgaaaacaag gtttcaggtg acgcccccag aataaaattt     4260

ggacgggggg ttcagtggtg gcattgtgct atgacaccaa tataaccctc acaaacccct     4320

tgggcaataa atactagtgt aggaatgaaa cattctgaat atctttaaca atagaaatcc     4380

atggggtggg gacaagccgt aaagactgga tgtccatctc acacgaattt atggctatgg     4440

gcaacacata atcctagtgc aatatgatac tggggttatt aagatgtgtc ccaggcaggg     4500

accaagacag gtgaaccatg ttgttacact ctatttgtaa caaggggaaa gagagtggac     4560

gccgacagca gcggactcca ctggttgtct ctaacacccc cgaaaattaa acggggctcc     4620

acgccaatgg ggcccataaa caaagacaag tggccactct tttttttgaa attgtggagt     4680

gggggcacgc gtcagccccc acacgccgcc ctgcggtttt ggactgtaaa ataagggtgt     4740

aataacttgg ctgattgtaa ccccgctaac cactgcggtc aaaccacttg cccacaaaac     4800

cactaatggc accccgggga atacctgcat aagtaggtgg gcgggccaag ataggggcgc     4860

gattgctgcg atctggagga caaattacac acacttgcgc ctgagcgcca agcacagggt     4920

tgttggtcct catattcacg aggtcgctga gagcacggtg ggctaatgtt gccatgggta     4980

gcatatacta cccaaatatc tggatagcat atgctatcct aatctatatc tgggtagcat     5040

aggctatcct aatctatatc tgggtagcat atgctatcct aatctatatc tgggtagtat     5100

atgctatcct aatttatatc tgggtagcat aggctatcct aatctatatc tgggtagcat     5160

atgctatcct aatctatatc tgggtagtat atgctatcct aatctgtatc cgggtagcat     5220

atgctatcct aatagagatt agggtagtat atgctatcct aatttatatc tgggtagcat     5280

atactaccca aatatctgga tagcatatgc tatcctaatc tatatctggg tagcatatgc     5340

tatcctaatc tatatctggg tagcataggc tatcctaatc tatatctggg tagcatatgc     5400

tatcctaatc tatatctggg tagtatatgc tatcctaatt tatatctggg tagcataggc     5460

tatcctaatc tatatctggg tagcatatgc tatcctaatc tatatctggg tagtatatgc     5520

tatcctaatc tgtatccggg tagcatatgc tatcctcatg ataagctgtc aaacatgaga     5580

attttcttga agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     5640

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     5700

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     5760

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     5820

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     5880

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     5940

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     6000

taaagttctg ctatgtggcg cggtattatc ccgtgttgac gccgggcaag agcaactcgg     6060

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     6120

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     6180

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     6240

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     6300

cataccaaac gacgagcgtg acaccacgat gcctgcagca atggcaacaa cgttgcgcaa     6360

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     6420

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     6480

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     6540

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     6600

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     6660

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     6720

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     6780

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     6840

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     6900

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     6960

aaatactgtt cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     7020

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     7080

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     7140

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     7200

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     7260

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     7320

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     7380

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     7440

cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt     7500

ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga     7560

gcgcagcgag tcagtgagcg aggaagcgga agagcgccca atacgcaaac cgcctctccc     7620

cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg tttcccgact ggaaagcggg     7680

cagtgagcgc aacgcaatta atgtgagtta gctcactcat taggcacccc aggctttaca     7740

ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc ggataacaat ttcacacagg     7800

aaacagctat gaccatgatt acgccaagct ctagctagag gtcgagtccc tccccagcag     7860

gcagaagtat gcaaagcatg catctcaatt agtcagcaac catagtcccg cccctaactc     7920

cgcccatccc gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa     7980

ttttttttat ttatgcagag gccgaggccg cctcggcctc tgagctattc cagaagtagt     8040

gaggaggctt ttttggaggc ctaggctttt gcaaaaagct ttgcaaagat ggataaagtt     8100

ttaaacagag aggaatcttt gcagctaatg gaccttctag gtcttgaaag g              8151


<210>  25
<211>  8153
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP175 ; pHybE-hCg4 V1

<400>  25
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgagc atttaaatgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcgt     2280

cgaccaaggg cccatccgtc ttccccctgg cgccctgctc caggagcacc tccgagagca     2340

cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga     2400

actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac     2460

tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacg aagacctaca     2520

cctgcaatgt agatcacaag cccagcaaca ccaaggtgga caagagagtt gagtccaaat     2580

acggtccgcc atgcccatca tgcccagcac ctgaattcct ggggggacca tcagtcttcc     2640

tgttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag gtcacgtgcg     2700

tggtggtgga cgtgagccag gaagaccccg aggtccagtt caactggtac gtggatggcg     2760

tggaggtgca taatgccaag acaaagccgc gggaggagca gttcaacagc acgtaccgtg     2820

tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa cggcaaggag tacaagtgca     2880

aggtctccaa caaaggcctc ccgtcctcca tcgagaaaac catctccaaa gccaaagggc     2940

agccccgaga gccacaggtg tacaccctgc ccccatccca ggaggagatg accaagaacc     3000

aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc gtggagtggg     3060

agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg gactccgacg     3120

gctccttctt cctctacagc aggctaaccg tggacaagag caggtggcag gaggggaatg     3180

tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag aagagcctct     3240

ccctgtctct gggtaaatga gcggccgctc gaggccggca aggccggatc ccccgacctc     3300

gacctctggc taataaagga aatttatttt cattgcaata gtgtgttgga attttttgtg     3360

tctctcactc ggaaggacat atgggagggc aaatcatttg gtcgagatcc ctcggagatc     3420

tctagctaga ggatcgatcc ccgccccgga cgaactaaac ctgactacga catctctgcc     3480

ccttcttcgc ggggcagtgc atgtaatccc ttcagttggt tggtacaact tgccaactgg     3540

gccctgttcc acatgtgaca cgggggggga ccaaacacaa aggggttctc tgactgtagt     3600

tgacatcctt ataaatggat gtgcacattt gccaacactg agtggctttc atcctggagc     3660

agactttgca gtctgtggac tgcaacacaa cattgccttt atgtgtaact cttggctgaa     3720

gctcttacac caatgctggg ggacatgtac ctcccagggg cccaggaaga ctacgggagg     3780

ctacaccaac gtcaatcaga ggggcctgtg tagctaccga taagcggacc ctcaagaggg     3840

cattagcaat agtgtttata aggccccctt gttaacccta aacgggtagc atatgcttcc     3900

cgggtagtag tatatactat ccagactaac cctaattcaa tagcatatgt tacccaacgg     3960

gaagcatatg ctatcgaatt agggttagta aaagggtcct aaggaacagc gatatctccc     4020

accccatgag ctgtcacggt tttatttaca tggggtcagg attccacgag ggtagtgaac     4080

cattttagtc acaagggcag tggctgaaga tcaaggagcg ggcagtgaac tctcctgaat     4140

cttcgcctgc ttcttcattc tccttcgttt agctaataga ataactgctg agttgtgaac     4200

agtaaggtgt atgtgaggtg ctcgaaaaca aggtttcagg tgacgccccc agaataaaat     4260

ttggacgggg ggttcagtgg tggcattgtg ctatgacacc aatataaccc tcacaaaccc     4320

cttgggcaat aaatactagt gtaggaatga aacattctga atatctttaa caatagaaat     4380

ccatggggtg gggacaagcc gtaaagactg gatgtccatc tcacacgaat ttatggctat     4440

gggcaacaca taatcctagt gcaatatgat actggggtta ttaagatgtg tcccaggcag     4500

ggaccaagac aggtgaacca tgttgttaca ctctatttgt aacaagggga aagagagtgg     4560

acgccgacag cagcggactc cactggttgt ctctaacacc cccgaaaatt aaacggggct     4620

ccacgccaat ggggcccata aacaaagaca agtggccact cttttttttg aaattgtgga     4680

gtgggggcac gcgtcagccc ccacacgccg ccctgcggtt ttggactgta aaataagggt     4740

gtaataactt ggctgattgt aaccccgcta accactgcgg tcaaaccact tgcccacaaa     4800

accactaatg gcaccccggg gaatacctgc ataagtaggt gggcgggcca agataggggc     4860

gcgattgctg cgatctggag gacaaattac acacacttgc gcctgagcgc caagcacagg     4920

gttgttggtc ctcatattca cgaggtcgct gagagcacgg tgggctaatg ttgccatggg     4980

tagcatatac tacccaaata tctggatagc atatgctatc ctaatctata tctgggtagc     5040

ataggctatc ctaatctata tctgggtagc atatgctatc ctaatctata tctgggtagt     5100

atatgctatc ctaatttata tctgggtagc ataggctatc ctaatctata tctgggtagc     5160

atatgctatc ctaatctata tctgggtagt atatgctatc ctaatctgta tccgggtagc     5220

atatgctatc ctaatagaga ttagggtagt atatgctatc ctaatttata tctgggtagc     5280

atatactacc caaatatctg gatagcatat gctatcctaa tctatatctg ggtagcatat     5340

gctatcctaa tctatatctg ggtagcatag gctatcctaa tctatatctg ggtagcatat     5400

gctatcctaa tctatatctg ggtagtatat gctatcctaa tttatatctg ggtagcatag     5460

gctatcctaa tctatatctg ggtagcatat gctatcctaa tctatatctg ggtagtatat     5520

gctatcctaa tctgtatccg ggtagcatat gctatcctca tgataagctg tcaaacatga     5580

gaattttctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg     5640

ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct     5700

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     5760

taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc     5820

cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg     5880

aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc     5940

aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact     6000

tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca agagcaactc     6060

ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag     6120

catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat     6180

aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt     6240

ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa     6300

gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac aacgttgcgc     6360

aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg     6420

gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt     6480

gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca     6540

gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat     6600

gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca     6660

gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg     6720

atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg     6780

ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt     6840

ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg     6900

ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata     6960

ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca     7020

ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag     7080

tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc     7140

tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga     7200

tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg     7260

tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac     7320

gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg     7380

tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg     7440

ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct     7500

gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc     7560

gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa accgcctctc     7620

cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg     7680

ggcagtgagc gcaacgcaat taatgtgagt tagctcactc attaggcacc ccaggcttta     7740

cactttatgc ttccggctcg tatgttgtgt ggaattgtga gcggataaca atttcacaca     7800

ggaaacagct atgaccatga ttacgccaag ctctagctag aggtcgagtc cctccccagc     7860

aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac     7920

tccgcccatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact     7980

aatttttttt atttatgcag aggccgaggc cgcctcggcc tctgagctat tccagaagta     8040

gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag ctttgcaaag atggataaag     8100

ttttaaacag agaggaatct ttgcagctaa tggaccttct aggtcttgaa agg            8153


<210>  26
<211>  8153
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pJP188 ; pHybE-hCg4 V2 

<400>  26
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgaga tccattgtgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg catggtatgc cgaaagggat     1320

gctgaaattg agaacgaaaa gctgcgccgg gaggttgaag aactgcggca ggccagcgag     1380

gcagatctcc agccaggaac tattgagtac gaacgccatc gacttacgcg tgcgcaggcc     1440

gacgcacagg aactgaagaa tgccagagac tccgctgaag tggtggaaac cgcattctgt     1500

actttcgtgc tgtcgcggat cgcaggtgaa attgccagta ttctcgacgg gctccccctg     1560

tcggtgcagc ggcgttttcc ggaactggaa aaccgacatg ttgatttcct gaaacgggat     1620

atcatcaaag ccatgaacaa agcagccgcg ctggatgaac tgataccggg gttgctgagt     1680

gaatatatcg aacagtcagg ttaacaggct gcggcatttt gtccgcgccg ggcttcgctc     1740

actgttcagg ccggagccac agaccgccgt tgaatgggcg gatgctaatt actatctccc     1800

gaaagaatcc gcataccagg aagggcgctg ggaaacactg ccctttcagc gggccatcat     1860

gaatgcgatg ggcagcgact acatccgtga ggtgaatgtg gtgaagtctg cccgtgtcgg     1920

ttattccaaa atgctgctgg gtgtttatgc ctactttata gagcataagc agcgcaacac     1980

ccttatctgg ttgccgacgg atggtgatgc cgagaacttt atgaaaaccc acgttgagcc     2040

gactattcgt gatattccgt cgctgctggc gctggccccg tggtatggca aaaagcaccg     2100

ggataacacg ctcaccatga agcgtttcac taatgggcgt ggcttctggt gcctgggcgg     2160

taaagcggca aaaaactacc gtgaaaagtc ggtggatgtg gcgggttatg atgaacttgc     2220

tgcttttgat gatgatattg aacaggaagg ctctccgacg ttcctgggtg acaagcgcgt     2280

cgaccaaggg cccatccgtc ttccccctgg cgccctgctc caggagcacc tccgagagca     2340

cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga     2400

actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac     2460

tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacg aagacctaca     2520

cctgcaatgt agatcacaag cccagcaaca ccaaggtgga caagagagtt gagtccaaat     2580

acggtccgcc atgcccatca tgcccagcac ctgaattcct ggggggacca tcagtcttcc     2640

tgttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag gtcacgtgcg     2700

tggtggtgga cgtgagccag gaagaccccg aggtccagtt caactggtac gtggatggcg     2760

tggaggtgca taatgccaag acaaagccgc gggaggagca gttcaacagc acgtaccgtg     2820

tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa cggcaaggag tacaagtgca     2880

aggtctccaa caaaggcctc ccgtcctcca tcgagaaaac catctccaaa gccaaagggc     2940

agccccgaga gccacaggtg tacaccctgc ccccatccca ggaggagatg accaagaacc     3000

aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc gtggagtggg     3060

agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg gactccgacg     3120

gctccttctt cctctacagc aggctaaccg tggacaagag caggtggcag gaggggaatg     3180

tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag aagagcctct     3240

ccctgtctct gggtaaatga gcggccgctc gaggccggca aggccggatc ccccgacctc     3300

gacctctggc taataaagga aatttatttt cattgcaata gtgtgttgga attttttgtg     3360

tctctcactc ggaaggacat atgggagggc aaatcatttg gtcgagatcc ctcggagatc     3420

tctagctaga ggatcgatcc ccgccccgga cgaactaaac ctgactacga catctctgcc     3480

ccttcttcgc ggggcagtgc atgtaatccc ttcagttggt tggtacaact tgccaactgg     3540

gccctgttcc acatgtgaca cgggggggga ccaaacacaa aggggttctc tgactgtagt     3600

tgacatcctt ataaatggat gtgcacattt gccaacactg agtggctttc atcctggagc     3660

agactttgca gtctgtggac tgcaacacaa cattgccttt atgtgtaact cttggctgaa     3720

gctcttacac caatgctggg ggacatgtac ctcccagggg cccaggaaga ctacgggagg     3780

ctacaccaac gtcaatcaga ggggcctgtg tagctaccga taagcggacc ctcaagaggg     3840

cattagcaat agtgtttata aggccccctt gttaacccta aacgggtagc atatgcttcc     3900

cgggtagtag tatatactat ccagactaac cctaattcaa tagcatatgt tacccaacgg     3960

gaagcatatg ctatcgaatt agggttagta aaagggtcct aaggaacagc gatatctccc     4020

accccatgag ctgtcacggt tttatttaca tggggtcagg attccacgag ggtagtgaac     4080

cattttagtc acaagggcag tggctgaaga tcaaggagcg ggcagtgaac tctcctgaat     4140

cttcgcctgc ttcttcattc tccttcgttt agctaataga ataactgctg agttgtgaac     4200

agtaaggtgt atgtgaggtg ctcgaaaaca aggtttcagg tgacgccccc agaataaaat     4260

ttggacgggg ggttcagtgg tggcattgtg ctatgacacc aatataaccc tcacaaaccc     4320

cttgggcaat aaatactagt gtaggaatga aacattctga atatctttaa caatagaaat     4380

ccatggggtg gggacaagcc gtaaagactg gatgtccatc tcacacgaat ttatggctat     4440

gggcaacaca taatcctagt gcaatatgat actggggtta ttaagatgtg tcccaggcag     4500

ggaccaagac aggtgaacca tgttgttaca ctctatttgt aacaagggga aagagagtgg     4560

acgccgacag cagcggactc cactggttgt ctctaacacc cccgaaaatt aaacggggct     4620

ccacgccaat ggggcccata aacaaagaca agtggccact cttttttttg aaattgtgga     4680

gtgggggcac gcgtcagccc ccacacgccg ccctgcggtt ttggactgta aaataagggt     4740

gtaataactt ggctgattgt aaccccgcta accactgcgg tcaaaccact tgcccacaaa     4800

accactaatg gcaccccggg gaatacctgc ataagtaggt gggcgggcca agataggggc     4860

gcgattgctg cgatctggag gacaaattac acacacttgc gcctgagcgc caagcacagg     4920

gttgttggtc ctcatattca cgaggtcgct gagagcacgg tgggctaatg ttgccatggg     4980

tagcatatac tacccaaata tctggatagc atatgctatc ctaatctata tctgggtagc     5040

ataggctatc ctaatctata tctgggtagc atatgctatc ctaatctata tctgggtagt     5100

atatgctatc ctaatttata tctgggtagc ataggctatc ctaatctata tctgggtagc     5160

atatgctatc ctaatctata tctgggtagt atatgctatc ctaatctgta tccgggtagc     5220

atatgctatc ctaatagaga ttagggtagt atatgctatc ctaatttata tctgggtagc     5280

atatactacc caaatatctg gatagcatat gctatcctaa tctatatctg ggtagcatat     5340

gctatcctaa tctatatctg ggtagcatag gctatcctaa tctatatctg ggtagcatat     5400

gctatcctaa tctatatctg ggtagtatat gctatcctaa tttatatctg ggtagcatag     5460

gctatcctaa tctatatctg ggtagcatat gctatcctaa tctatatctg ggtagtatat     5520

gctatcctaa tctgtatccg ggtagcatat gctatcctca tgataagctg tcaaacatga     5580

gaattttctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg     5640

ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct     5700

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     5760

taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc     5820

cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg     5880

aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc     5940

aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact     6000

tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg acgccgggca agagcaactc     6060

ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag     6120

catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat     6180

aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt     6240

ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa     6300

gccataccaa acgacgagcg tgacaccacg atgcctgcag caatggcaac aacgttgcgc     6360

aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg     6420

gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt     6480

gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca     6540

gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat     6600

gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca     6660

gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg     6720

atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg     6780

ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt     6840

ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg     6900

ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata     6960

ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca     7020

ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag     7080

tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc     7140

tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga     7200

tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg     7260

tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac     7320

gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg     7380

tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg     7440

ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct     7500

gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc     7560

gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa accgcctctc     7620

cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg     7680

ggcagtgagc gcaacgcaat taatgtgagt tagctcactc attaggcacc ccaggcttta     7740

cactttatgc ttccggctcg tatgttgtgt ggaattgtga gcggataaca atttcacaca     7800

ggaaacagct atgaccatga ttacgccaag ctctagctag aggtcgagtc cctccccagc     7860

aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac     7920

tccgcccatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact     7980

aatttttttt atttatgcag aggccgaggc cgcctcggcc tctgagctat tccagaagta     8040

gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag ctttgcaaag atggataaag     8100

ttttaaacag agaggaatct ttgcagctaa tggaccttct aggtcttgaa agg            8153


<210>  27
<211>  7244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pHybC-mBR3-mCg2a 

<400>  27
ttgacattga ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag       60

cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc      120

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      180

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca      240

tcaagtgtat catatgccaa gtccgccccc tattgacgtc aatgacggta aatggcccgc      300

ctggcattat gcccagtaca tgaccttacg ggactttcct acttggcagt acatctacgt      360

attagtcatc gctattacca tggtgatgcg gttttggcag tacaccaatg ggcgtggata      420

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt      480

ttggcaccaa aatcaacggg actttccaaa atgtcgtaat aaccccgccc cgttgacgca      540

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt tagtgaaccg      600

tcagatcctc actctcttcc gcatcgctgt ctgcgagggc cagctgttgg gctcgcggtt      660

gaggacaaac tcttcgcggt ctttccagta ctcttggatc ggaaacccgt cggcctccga      720

acggtactcc gccaccgagg gacctgagcg agtccgcatc gaccggatcg gaaaacctct      780

cgagaaaggc gtctaaccag tcacagtcgc aaggtaggct gagcaccgtg gcgggcggca      840

gcgggtggcg gtcggggttg tttctggcgg aggtgctgct gatgatgtaa ttaaagtagg      900

cggtcttgag acggcggatg gtcgaggtga ggtgtggcag gcttgagatc cagctgttgg      960

ggtgagtact ccctctcaaa agcgggcatt acttctgcgc taagattgtc agtttccaaa     1020

aacgaggagg atttgatatt cacctggccc gatctggcca tacacttgag tgacaatgac     1080

atccactttg cctttctctc cacaggtgtc cactcccagg tccaagtttg ggcgccacca     1140

tggagtttgg gctgagctgg ctttttcttg tcgcgatttt aaaaggtgtc cagtgcggcg     1200

ccaggagact ccgggtccga agccagagga gccgggacag ctcggtgccc acccagtgca     1260

atcagaccga gtgcttcgac cctctggtga gaaactgcgt gtcctgtgag ctcttccaca     1320

cgccggacac tggacataca agcagcctgg agcctgggac agctctgcag cctcaggagg     1380

gctccgcgct gagacccgac gtggcggagc ccagagggcc cacaatcaag ccctgtcctc     1440

catgcaaatg cccagcacct aacctcttgg gtggaccatc cgtcttcatc ttccctccaa     1500

agatcaagga tgtactcatg atctccctga gccccatagt cacatgtgtg gtggtggatg     1560

tgagcgagga tgacccagat gtccagatca gctggtttgt gaacaacgtg gaagtacaca     1620

cagctcagac acaaacccat agagaggatt acaacagtac tctccgggtg gtcagtgccc     1680

tccccatcca gcaccaggac tggatgagtg gcaaggagtt caaatgcaag gtcaacaaca     1740

aagacctccc agcgcccatc gagagaacca tctcaaaacc caaagggtca gtaagagctc     1800

cacaggtata tgtcttgcct ccaccagaag aagagatgac taagaaacag gtcactctga     1860

cctgcatggt cacagacttc atgcctgaag acatttacgt ggagtggacc aacaacggga     1920

aaacagagct aaactacaag aacactgaac cagtcctgga ctctgatggt tcttacttca     1980

tgtacagcaa gctgagagtg gaaaagaaga actgggtgga aagaaatagc tactcctgtt     2040

cagtggtcca cgagggtctg cacaatcacc acacgactaa gagcttctcc cggactccgg     2100

gtaaataagc ggccgctcga ggccggcaag gccggatccc ccgacctcga cctctggcta     2160

ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg     2220

aaggacatat gggagggcaa atcatttggt cgagatccct cggagatctc tagctagagg     2280

atcgatcccc gccccggacg aactaaacct gactacgaca tctctgcccc ttcttcgcgg     2340

ggcagtgcat gtaatccctt cagttggttg gtacaacttg ccaactgggc cctgttccac     2400

atgtgacacg gggggggacc aaacacaaag gggttctctg actgtagttg acatccttat     2460

aaatggatgt gcacatttgc caacactgag tggctttcat cctggagcag actttgcagt     2520

ctgtggactg caacacaaca ttgcctttat gtgtaactct tggctgaagc tcttacacca     2580

atgctggggg acatgtacct cccaggggcc caggaagact acgggaggct acaccaacgt     2640

caatcagagg ggcctgtgta gctaccgata agcggaccct caagagggca ttagcaatag     2700

tgtttataag gcccccttgt taaccctaaa cgggtagcat atgcttcccg ggtagtagta     2760

tatactatcc agactaaccc taattcaata gcatatgtta cccaacggga agcatatgct     2820

atcgaattag ggttagtaaa agggtcctaa ggaacagcga tatctcccac cccatgagct     2880

gtcacggttt tatttacatg gggtcaggat tccacgaggg tagtgaacca ttttagtcac     2940

aagggcagtg gctgaagatc aaggagcggg cagtgaactc tcctgaatct tcgcctgctt     3000

cttcattctc cttcgtttag ctaatagaat aactgctgag ttgtgaacag taaggtgtat     3060

gtgaggtgct cgaaaacaag gtttcaggtg acgcccccag aataaaattt ggacgggggg     3120

ttcagtggtg gcattgtgct atgacaccaa tataaccctc acaaacccct tgggcaataa     3180

atactagtgt aggaatgaaa cattctgaat atctttaaca atagaaatcc atggggtggg     3240

gacaagccgt aaagactgga tgtccatctc acacgaattt atggctatgg gcaacacata     3300

atcctagtgc aatatgatac tggggttatt aagatgtgtc ccaggcaggg accaagacag     3360

gtgaaccatg ttgttacact ctatttgtaa caaggggaaa gagagtggac gccgacagca     3420

gcggactcca ctggttgtct ctaacacccc cgaaaattaa acggggctcc acgccaatgg     3480

ggcccataaa caaagacaag tggccactct tttttttgaa attgtggagt gggggcacgc     3540

gtcagccccc acacgccgcc ctgcggtttt ggactgtaaa ataagggtgt aataacttgg     3600

ctgattgtaa ccccgctaac cactgcggtc aaaccacttg cccacaaaac cactaatggc     3660

accccgggga atacctgcat aagtaggtgg gcgggccaag ataggggcgc gattgctgcg     3720

atctggagga caaattacac acacttgcgc ctgagcgcca agcacagggt tgttggtcct     3780

catattcacg aggtcgctga gagcacggtg ggctaatgtt gccatgggta gcatatacta     3840

cccaaatatc tggatagcat atgctatcct aatctatatc tgggtagcat aggctatcct     3900

aatctatatc tgggtagcat atgctatcct aatctatatc tgggtagtat atgctatcct     3960

aatttatatc tgggtagcat aggctatcct aatctatatc tgggtagcat atgctatcct     4020

aatctatatc tgggtagtat atgctatcct aatctgtatc cgggtagcat atgctatcct     4080

aatagagatt agggtagtat atgctatcct aatttatatc tgggtagcat atactaccca     4140

aatatctgga tagcatatgc tatcctaatc tatatctggg tagcatatgc tatcctaatc     4200

tatatctggg tagcataggc tatcctaatc tatatctggg tagcatatgc tatcctaatc     4260

tatatctggg tagtatatgc tatcctaatt tatatctggg tagcataggc tatcctaatc     4320

tatatctggg tagcatatgc tatcctaatc tatatctggg tagtatatgc tatcctaatc     4380

tgtatccggg tagcatatgc tatcctcatg ataagctgtc aaacatgaga attttcttga     4440

agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat aataatggtt     4500

tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt     4560

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa     4620

taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt     4680

tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat     4740

gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag     4800

atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg     4860

ctatgtggcg cggtattatc ccgtgttgac gccgggcaag agcaactcgg tcgccgcata     4920

cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat     4980

ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc     5040

aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg     5100

ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac     5160

gacgagcgtg acaccacgat gcctgcagca atggcaacaa cgttgcgcaa actattaact     5220

ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa     5280

gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct     5340

ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc     5400

tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga     5460

cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac     5520

tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag     5580

atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg     5640

tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc     5700

tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag     5760

ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtt     5820

cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac     5880

ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc     5940

gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt     6000

tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt     6060

gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc     6120

ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt     6180

tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca     6240

ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt     6300

tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt     6360

attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag     6420

tcagtgagcg aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg     6480

ccgattcatt aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc     6540

aacgcaatta atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt     6600

ccggctcgta tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat     6660

gaccatgatt acgccaagct ctagctagag gtcgagtccc tccccagcag gcagaagtat     6720

gcaaagcatg catctcaatt agtcagcaac catagtcccg cccctaactc cgcccatccc     6780

gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat     6840

ttatgcagag gccgaggccg cctcggcctc tgagctattc cagaagtagt gaggaggctt     6900

ttttggaggc ctaggctttt gcaaaaagct ttgcaaagat ggataaagtt ttaaacagag     6960

aggaatcttt gcagctaatg gaccttctag gtcttgaaag gagctcgacc aattctcatg     7020

tttgacagct tatcatcgca gatccgggca acgttgttgc cattgctgca ggcgcagaac     7080

tggtaggtat ggaagatcta tacattgaat caatattggc aattagccat attagtcatt     7140

ggttatatag cataaatcaa tattggctat tggccattgc atacgttgta tctatatcat     7200

aatatgtaca tttatattgg ctcatgtcca atatgaccgc catg                      7244


<210>  28
<211>  7104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pHybE-mBR3-mCg2a 

<400>  28
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgaga tccattgtgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgcg gcgccaggag actccgggtc     1320

cgaagccaga ggagccggga cagctcggtg cccacccagt gcaatcagac cgagtgcttc     1380

gaccctctgg tgagaaactg cgtgtcctgt gagctcttcc acacgccgga cactggacat     1440

acaagcagcc tggagcctgg gacagctctg cagcctcagg agggctccgc gctgagaccc     1500

gacgtggcgg agcccagagg gcccacaatc aagccctgtc ctccatgcaa atgcccagca     1560

cctaacctct tgggtggacc atccgtcttc atcttccctc caaagatcaa ggatgtactc     1620

atgatctccc tgagccccat agtcacatgt gtggtggtgg atgtgagcga ggatgaccca     1680

gatgtccaga tcagctggtt tgtgaacaac gtggaagtac acacagctca gacacaaacc     1740

catagagagg attacaacag tactctccgg gtggtcagtg ccctccccat ccagcaccag     1800

gactggatga gtggcaagga gttcaaatgc aaggtcaaca acaaagacct cccagcgccc     1860

atcgagagaa ccatctcaaa acccaaaggg tcagtaagag ctccacaggt atatgtcttg     1920

cctccaccag aagaagagat gactaagaaa caggtcactc tgacctgcat ggtcacagac     1980

ttcatgcctg aagacattta cgtggagtgg accaacaacg ggaaaacaga gctaaactac     2040

aagaacactg aaccagtcct ggactctgat ggttcttact tcatgtacag caagctgaga     2100

gtggaaaaga agaactgggt ggaaagaaat agctactcct gttcagtggt ccacgagggt     2160

ctgcacaatc accacacgac taagagcttc tcccggactc cgggtaaata agcggccgct     2220

cgaggccggc aaggccggat cccccgacct cgacctctgg ctaataaagg aaatttattt     2280

tcattgcaat agtgtgttgg aattttttgt gtctctcact cggaaggaca tatgggaggg     2340

caaatcattt ggtcgagatc cctcggagat ctctagctag aggatcgatc cccgccccgg     2400

acgaactaaa cctgactacg acatctctgc cccttcttcg cggggcagtg catgtaatcc     2460

cttcagttgg ttggtacaac ttgccaactg ggccctgttc cacatgtgac acgggggggg     2520

accaaacaca aaggggttct ctgactgtag ttgacatcct tataaatgga tgtgcacatt     2580

tgccaacact gagtggcttt catcctggag cagactttgc agtctgtgga ctgcaacaca     2640

acattgcctt tatgtgtaac tcttggctga agctcttaca ccaatgctgg gggacatgta     2700

cctcccaggg gcccaggaag actacgggag gctacaccaa cgtcaatcag aggggcctgt     2760

gtagctaccg ataagcggac cctcaagagg gcattagcaa tagtgtttat aaggccccct     2820

tgttaaccct aaacgggtag catatgcttc ccgggtagta gtatatacta tccagactaa     2880

ccctaattca atagcatatg ttacccaacg ggaagcatat gctatcgaat tagggttagt     2940

aaaagggtcc taaggaacag cgatatctcc caccccatga gctgtcacgg ttttatttac     3000

atggggtcag gattccacga gggtagtgaa ccattttagt cacaagggca gtggctgaag     3060

atcaaggagc gggcagtgaa ctctcctgaa tcttcgcctg cttcttcatt ctccttcgtt     3120

tagctaatag aataactgct gagttgtgaa cagtaaggtg tatgtgaggt gctcgaaaac     3180

aaggtttcag gtgacgcccc cagaataaaa tttggacggg gggttcagtg gtggcattgt     3240

gctatgacac caatataacc ctcacaaacc ccttgggcaa taaatactag tgtaggaatg     3300

aaacattctg aatatcttta acaatagaaa tccatggggt ggggacaagc cgtaaagact     3360

ggatgtccat ctcacacgaa tttatggcta tgggcaacac ataatcctag tgcaatatga     3420

tactggggtt attaagatgt gtcccaggca gggaccaaga caggtgaacc atgttgttac     3480

actctatttg taacaagggg aaagagagtg gacgccgaca gcagcggact ccactggttg     3540

tctctaacac ccccgaaaat taaacggggc tccacgccaa tggggcccat aaacaaagac     3600

aagtggccac tctttttttt gaaattgtgg agtgggggca cgcgtcagcc cccacacgcc     3660

gccctgcggt tttggactgt aaaataaggg tgtaataact tggctgattg taaccccgct     3720

aaccactgcg gtcaaaccac ttgcccacaa aaccactaat ggcaccccgg ggaatacctg     3780

cataagtagg tgggcgggcc aagatagggg cgcgattgct gcgatctgga ggacaaatta     3840

cacacacttg cgcctgagcg ccaagcacag ggttgttggt cctcatattc acgaggtcgc     3900

tgagagcacg gtgggctaat gttgccatgg gtagcatata ctacccaaat atctggatag     3960

catatgctat cctaatctat atctgggtag cataggctat cctaatctat atctgggtag     4020

catatgctat cctaatctat atctgggtag tatatgctat cctaatttat atctgggtag     4080

cataggctat cctaatctat atctgggtag catatgctat cctaatctat atctgggtag     4140

tatatgctat cctaatctgt atccgggtag catatgctat cctaatagag attagggtag     4200

tatatgctat cctaatttat atctgggtag catatactac ccaaatatct ggatagcata     4260

tgctatccta atctatatct gggtagcata tgctatccta atctatatct gggtagcata     4320

ggctatccta atctatatct gggtagcata tgctatccta atctatatct gggtagtata     4380

tgctatccta atttatatct gggtagcata ggctatccta atctatatct gggtagcata     4440

tgctatccta atctatatct gggtagtata tgctatccta atctgtatcc gggtagcata     4500

tgctatcctc atgataagct gtcaaacatg agaattttct tgaagacgaa agggcctcgt     4560

gatacgccta tttttatagg ttaatgtcat gataataatg gtttcttaga cgtcaggtgg     4620

cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa     4680

tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa     4740

gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct     4800

tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg     4860

tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg     4920

ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt     4980

atcccgtgtt gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga     5040

cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga     5100

attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac     5160

gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg     5220

ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac     5280

gatgcctgca gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct     5340

agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct     5400

gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg     5460

gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat     5520

ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg     5580

tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat     5640

tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct     5700

catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa     5760

gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa     5820

aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc     5880

gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag tgtagccgta     5940

gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct     6000

gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg     6060

atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag     6120

cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc     6180

cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg     6240

agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt     6300

tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg     6360

gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca     6420

catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg     6480

agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc     6540

ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag     6600

ctggcacgac aggtttcccg actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag     6660

ttagctcact cattaggcac cccaggcttt acactttatg cttccggctc gtatgttgtg     6720

tggaattgtg agcggataac aatttcacac aggaaacagc tatgaccatg attacgccaa     6780

gctctagcta gaggtcgagt ccctccccag caggcagaag tatgcaaagc atgcatctca     6840

attagtcagc aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca     6900

gttccgccca ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg     6960

ccgcctcggc ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct     7020

tttgcaaaaa gctttgcaaa gatggataaa gttttaaaca gagaggaatc tttgcagcta     7080

atggaccttc taggtcttga aagg                                            7104


<210>  29
<211>  6985
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pHybC-E7-hCk 

<400>  29
ttgacattga ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag       60

cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc      120

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      180

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca      240

tcaagtgtat catatgccaa gtccgccccc tattgacgtc aatgacggta aatggcccgc      300

ctggcattat gcccagtaca tgaccttacg ggactttcct acttggcagt acatctacgt      360

attagtcatc gctattacca tggtgatgcg gttttggcag tacaccaatg ggcgtggata      420

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt      480

ttggcaccaa aatcaacggg actttccaaa atgtcgtaat aaccccgccc cgttgacgca      540

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt tagtgaaccg      600

tcagatcctc actctcttcc gcatcgctgt ctgcgagggc cagctgttgg gctcgcggtt      660

gaggacaaac tcttcgcggt ctttccagta ctcttggatc ggaaacccgt cggcctccga      720

acggtactcc gccaccgagg gacctgagcg agtccgcatc gaccggatcg gaaaacctct      780

cgagaaaggc gtctaaccag tcacagtcgc aaggtaggct gagcaccgtg gcgggcggca      840

gcgggtggcg gtcggggttg tttctggcgg aggtgctgct gatgatgtaa ttaaagtagg      900

cggtcttgag acggcggatg gtcgaggtga ggtgtggcag gcttgagatc cagctgttgg      960

ggtgagtact ccctctcaaa agcgggcatt acttctgcgc taagattgtc agtttccaaa     1020

aacgaggagg atttgatatt cacctggccc gatctggcca tacacttgag tgacaatgac     1080

atccactttg cctttctctc cacaggtgtc cactcccagg tccaagtttg ggcgcaccat     1140

ggacatgcgc gtgcccgccc agctgctggg cctgctgctg ctgtggttcc ccggctcgcg     1200

atgcgacatc cagatgaccc agtctccatc ctccctgtct gcatctatag gggacagagt     1260

caccatcact tgtcgggcaa gtcagggcat cagaaattac ttagcctggt atcagcaaaa     1320

accagggaaa gcccctaagc tcctgatcta tgctgcatcc actttgcaat caggggtccc     1380

atctcggttc agtggcagtg gatctgggac agatttcact ctcaccatca gcagcctaca     1440

gcctgaagat gttgcaactt attactgtca aaggtataac cgtgccccgt acacttttgg     1500

ccaggggacc aaggtggaaa tcaaacgtac ggtggctgca ccatctgtct tcatcttccc     1560

gccatctgat gagcagttga aatctggaac tgcctctgtt gtgtgcctgc tgaataactt     1620

ctatcccaga gaggccaaag tacagtggaa ggtggataac gccctccaat cgggtaactc     1680

ccaggagagt gtcacagagc aggacagcaa ggacagcacc tacagcctca gcagcaccct     1740

gacgctgagc aaagcagact acgagaaaca caaagtctac gcctgcgaag tcacccatca     1800

gggcctgagc tcgcccgtca caaagagctt caacagggga gagtgttgag cggccgctcg     1860

aggccggcaa ggccggatcc cccgacctcg acctctggct aataaaggaa atttattttc     1920

attgcaatag tgtgttggaa ttttttgtgt ctctcactcg gaaggacata tgggagggca     1980

aatcatttgg tcgagatccc tcggagatct ctagctagag gatcgatccc cgccccggac     2040

gaactaaacc tgactacgac atctctgccc cttcttcgcg gggcagtgca tgtaatccct     2100

tcagttggtt ggtacaactt gccaactggg ccctgttcca catgtgacac ggggggggac     2160

caaacacaaa ggggttctct gactgtagtt gacatcctta taaatggatg tgcacatttg     2220

ccaacactga gtggctttca tcctggagca gactttgcag tctgtggact gcaacacaac     2280

attgccttta tgtgtaactc ttggctgaag ctcttacacc aatgctgggg gacatgtacc     2340

tcccaggggc ccaggaagac tacgggaggc tacaccaacg tcaatcagag gggcctgtgt     2400

agctaccgat aagcggaccc tcaagagggc attagcaata gtgtttataa ggcccccttg     2460

ttaaccctaa acgggtagca tatgcttccc gggtagtagt atatactatc cagactaacc     2520

ctaattcaat agcatatgtt acccaacggg aagcatatgc tatcgaatta gggttagtaa     2580

aagggtccta aggaacagcg atatctccca ccccatgagc tgtcacggtt ttatttacat     2640

ggggtcagga ttccacgagg gtagtgaacc attttagtca caagggcagt ggctgaagat     2700

caaggagcgg gcagtgaact ctcctgaatc ttcgcctgct tcttcattct ccttcgttta     2760

gctaatagaa taactgctga gttgtgaaca gtaaggtgta tgtgaggtgc tcgaaaacaa     2820

ggtttcaggt gacgccccca gaataaaatt tggacggggg gttcagtggt ggcattgtgc     2880

tatgacacca atataaccct cacaaacccc ttgggcaata aatactagtg taggaatgaa     2940

acattctgaa tatctttaac aatagaaatc catggggtgg ggacaagccg taaagactgg     3000

atgtccatct cacacgaatt tatggctatg ggcaacacat aatcctagtg caatatgata     3060

ctggggttat taagatgtgt cccaggcagg gaccaagaca ggtgaaccat gttgttacac     3120

tctatttgta acaaggggaa agagagtgga cgccgacagc agcggactcc actggttgtc     3180

tctaacaccc ccgaaaatta aacggggctc cacgccaatg gggcccataa acaaagacaa     3240

gtggccactc ttttttttga aattgtggag tgggggcacg cgtcagcccc cacacgccgc     3300

cctgcggttt tggactgtaa aataagggtg taataacttg gctgattgta accccgctaa     3360

ccactgcggt caaaccactt gcccacaaaa ccactaatgg caccccgggg aatacctgca     3420

taagtaggtg ggcgggccaa gataggggcg cgattgctgc gatctggagg acaaattaca     3480

cacacttgcg cctgagcgcc aagcacaggg ttgttggtcc tcatattcac gaggtcgctg     3540

agagcacggt gggctaatgt tgccatgggt agcatatact acccaaatat ctggatagca     3600

tatgctatcc taatctatat ctgggtagca taggctatcc taatctatat ctgggtagca     3660

tatgctatcc taatctatat ctgggtagta tatgctatcc taatttatat ctgggtagca     3720

taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta     3780

tatgctatcc taatctgtat ccgggtagca tatgctatcc taatagagat tagggtagta     3840

tatgctatcc taatttatat ctgggtagca tatactaccc aaatatctgg atagcatatg     3900

ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagcatagg     3960

ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagtatatg     4020

ctatcctaat ttatatctgg gtagcatagg ctatcctaat ctatatctgg gtagcatatg     4080

ctatcctaat ctatatctgg gtagtatatg ctatcctaat ctgtatccgg gtagcatatg     4140

ctatcctcat gataagctgt caaacatgag aattttcttg aagacgaaag ggcctcgtga     4200

tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca     4260

cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata     4320

tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga     4380

gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc     4440

ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg     4500

cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc     4560

ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat     4620

cccgtgttga cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact     4680

tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat     4740

tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga     4800

tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc     4860

ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga     4920

tgcctgcagc aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag     4980

cttcccggca acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc     5040

gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt     5100

ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct     5160

acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg     5220

cctcactgat taagcattgg taactgtcag accaagttta ctcatatata ctttagattg     5280

atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca     5340

tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga     5400

tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa     5460

aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga     5520

aggtaactgg cttcagcaga gcgcagatac caaatactgt tcttctagtg tagccgtagt     5580

taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt     5640

taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat     5700

agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct     5760

tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca     5820

cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag     5880

agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc     5940

gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga     6000

aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca     6060

tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag     6120

ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg     6180

aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct     6240

ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt     6300

agctcactca ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg     6360

gaattgtgag cggataacaa tttcacacag gaaacagcta tgaccatgat tacgccaagc     6420

tctagctaga ggtcgagtcc ctccccagca ggcagaagta tgcaaagcat gcatctcaat     6480

tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt     6540

tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc     6600

gcctcggcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt     6660

tgcaaaaagc tttgcaaaga tggataaagt tttaaacaga gaggaatctt tgcagctaat     6720

ggaccttcta ggtcttgaaa ggagctcgac caattctcat gtttgacagc ttatcatcgc     6780

agatccgggc aacgttgttg ccattgctgc aggcgcagaa ctggtaggta tggaagatct     6840

atacattgaa tcaatattgg caattagcca tattagtcat tggttatata gcataaatca     6900

atattggcta ttggccattg catacgttgt atctatatca taatatgtac atttatattg     6960

gctcatgtcc aatatgaccg ccatg                                           6985


<210>  30
<211>  7688
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pHybC-D2-hCg1,z,a 

<400>  30
ttgacattga ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag       60

cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc      120

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      180

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca      240

tcaagtgtat catatgccaa gtccgccccc tattgacgtc aatgacggta aatggcccgc      300

ctggcattat gcccagtaca tgaccttacg ggactttcct acttggcagt acatctacgt      360

attagtcatc gctattacca tggtgatgcg gttttggcag tacaccaatg ggcgtggata      420

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt      480

ttggcaccaa aatcaacggg actttccaaa atgtcgtaat aaccccgccc cgttgacgca      540

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt tagtgaaccg      600

tcagatcctc actctcttcc gcatcgctgt ctgcgagggc cagctgttgg gctcgcggtt      660

gaggacaaac tcttcgcggt ctttccagta ctcttggatc ggaaacccgt cggcctccga      720

acggtactcc gccaccgagg gacctgagcg agtccgcatc gaccggatcg gaaaacctct      780

cgagaaaggc gtctaaccag tcacagtcgc aaggtaggct gagcaccgtg gcgggcggca      840

gcgggtggcg gtcggggttg tttctggcgg aggtgctgct gatgatgtaa ttaaagtagg      900

cggtcttgag acggcggatg gtcgaggtga ggtgtggcag gcttgagatc cagctgttgg      960

ggtgagtact ccctctcaaa agcgggcatt acttctgcgc taagattgtc agtttccaaa     1020

aacgaggagg atttgatatt cacctggccc gatctggcca tacacttgag tgacaatgac     1080

atccactttg cctttctctc cacaggtgtc cactcccagg tccaagtttg ggcgccacca     1140

tggagtttgg gctgagctgg ctttttcttg tcgcgatttt aaaaggtgtc cagtgtgagg     1200

tgcagctggt ggagtctggg ggaggcttgg tacagcccgg caggtccctg agactctcct     1260

gtgcggcctc tggattcacc tttgatgatt atgccatgca ctgggtccgg caagctccag     1320

ggaagggcct ggaatgggtc tcagctatca cttggaatag tggtcacata gactatgcgg     1380

actctgtgga gggccgattc accatctcca gagacaacgc caagaactcc ctgtatctgc     1440

aaatgaacag tctgagagct gaggatacgg ccgtatatta ctgtgcgaaa gtctcgtacc     1500

ttagcaccgc gtcctccctt gactattggg gccaaggtac cctggtcacc gtctcgagtg     1560

cgtcgaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc acctctgggg     1620

gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg acggtgtcgt     1680

ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta cagtcctcag     1740

gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc acccagacct     1800

acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa gttgagccca     1860

aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc ctggggggac     1920

cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc cggacccctg     1980

aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt     2040

acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag cagtacaaca     2100

gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg aatggcaagg     2160

agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa accatctcca     2220

aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc cgggatgagc     2280

tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc agcgacatcg     2340

ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg cctcccgtgc     2400

tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag agcaggtggc     2460

agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac cactacacgc     2520

agaagagcct ctccctgtct ccgggtaaat gagcggccgc tcgaggccgg caaggccgga     2580

tcccccgacc tcgacctctg gctaataaag gaaatttatt ttcattgcaa tagtgtgttg     2640

gaattttttg tgtctctcac tcggaaggac atatgggagg gcaaatcatt tggtcgagat     2700

ccctcggaga tctctagcta gaggatcgat ccccgccccg gacgaactaa acctgactac     2760

gacatctctg ccccttcttc gcggggcagt gcatgtaatc ccttcagttg gttggtacaa     2820

cttgccaact gggccctgtt ccacatgtga cacggggggg gaccaaacac aaaggggttc     2880

tctgactgta gttgacatcc ttataaatgg atgtgcacat ttgccaacac tgagtggctt     2940

tcatcctgga gcagactttg cagtctgtgg actgcaacac aacattgcct ttatgtgtaa     3000

ctcttggctg aagctcttac accaatgctg ggggacatgt acctcccagg ggcccaggaa     3060

gactacggga ggctacacca acgtcaatca gaggggcctg tgtagctacc gataagcgga     3120

ccctcaagag ggcattagca atagtgttta taaggccccc ttgttaaccc taaacgggta     3180

gcatatgctt cccgggtagt agtatatact atccagacta accctaattc aatagcatat     3240

gttacccaac gggaagcata tgctatcgaa ttagggttag taaaagggtc ctaaggaaca     3300

gcgatatctc ccaccccatg agctgtcacg gttttattta catggggtca ggattccacg     3360

agggtagtga accattttag tcacaagggc agtggctgaa gatcaaggag cgggcagtga     3420

actctcctga atcttcgcct gcttcttcat tctccttcgt ttagctaata gaataactgc     3480

tgagttgtga acagtaaggt gtatgtgagg tgctcgaaaa caaggtttca ggtgacgccc     3540

ccagaataaa atttggacgg ggggttcagt ggtggcattg tgctatgaca ccaatataac     3600

cctcacaaac cccttgggca ataaatacta gtgtaggaat gaaacattct gaatatcttt     3660

aacaatagaa atccatgggg tggggacaag ccgtaaagac tggatgtcca tctcacacga     3720

atttatggct atgggcaaca cataatccta gtgcaatatg atactggggt tattaagatg     3780

tgtcccaggc agggaccaag acaggtgaac catgttgtta cactctattt gtaacaaggg     3840

gaaagagagt ggacgccgac agcagcggac tccactggtt gtctctaaca cccccgaaaa     3900

ttaaacgggg ctccacgcca atggggccca taaacaaaga caagtggcca ctcttttttt     3960

tgaaattgtg gagtgggggc acgcgtcagc ccccacacgc cgccctgcgg ttttggactg     4020

taaaataagg gtgtaataac ttggctgatt gtaaccccgc taaccactgc ggtcaaacca     4080

cttgcccaca aaaccactaa tggcaccccg gggaatacct gcataagtag gtgggcgggc     4140

caagataggg gcgcgattgc tgcgatctgg aggacaaatt acacacactt gcgcctgagc     4200

gccaagcaca gggttgttgg tcctcatatt cacgaggtcg ctgagagcac ggtgggctaa     4260

tgttgccatg ggtagcatat actacccaaa tatctggata gcatatgcta tcctaatcta     4320

tatctgggta gcataggcta tcctaatcta tatctgggta gcatatgcta tcctaatcta     4380

tatctgggta gtatatgcta tcctaattta tatctgggta gcataggcta tcctaatcta     4440

tatctgggta gcatatgcta tcctaatcta tatctgggta gtatatgcta tcctaatctg     4500

tatccgggta gcatatgcta tcctaataga gattagggta gtatatgcta tcctaattta     4560

tatctgggta gcatatacta cccaaatatc tggatagcat atgctatcct aatctatatc     4620

tgggtagcat atgctatcct aatctatatc tgggtagcat aggctatcct aatctatatc     4680

tgggtagcat atgctatcct aatctatatc tgggtagtat atgctatcct aatttatatc     4740

tgggtagcat aggctatcct aatctatatc tgggtagcat atgctatcct aatctatatc     4800

tgggtagtat atgctatcct aatctgtatc cgggtagcat atgctatcct catgataagc     4860

tgtcaaacat gagaattttc ttgaagacga aagggcctcg tgatacgcct atttttatag     4920

gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg     4980

cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga     5040

caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat     5100

ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca     5160

gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc     5220

gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca     5280

atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtgt tgacgccggg     5340

caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca     5400

gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata     5460

accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag     5520

ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg     5580

gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgc agcaatggca     5640

acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaatta     5700

atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct     5760

ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca     5820

gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag     5880

gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat     5940

tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa acttcatttt     6000

taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa     6060

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     6120

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     6180

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     6240

agagcgcaga taccaaatac tgttcttcta gtgtagccgt agttaggcca ccacttcaag     6300

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     6360

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     6420

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     6480

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     6540

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     6600

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     6660

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     6720

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     6780

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     6840

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cccaatacgc     6900

aaaccgcctc tccccgcgcg ttggccgatt cattaatgca gctggcacga caggtttccc     6960

gactggaaag cgggcagtga gcgcaacgca attaatgtga gttagctcac tcattaggca     7020

ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa     7080

caatttcaca caggaaacag ctatgaccat gattacgcca agctctagct agaggtcgag     7140

tccctcccca gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccatagt     7200

cccgccccta actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc     7260

ccatggctga ctaatttttt ttatttatgc agaggccgag gccgcctcgg cctctgagct     7320

attccagaag tagtgaggag gcttttttgg aggcctaggc ttttgcaaaa agctttgcaa     7380

agatggataa agttttaaac agagaggaat ctttgcagct aatggacctt ctaggtcttg     7440

aaaggagctc gaccaattct catgtttgac agcttatcat cgcagatccg ggcaacgttg     7500

ttgccattgc tgcaggcgca gaactggtag gtatggaaga tctatacatt gaatcaatat     7560

tggcaattag ccatattagt cattggttat atagcataaa tcaatattgg ctattggcca     7620

ttgcatacgt tgtatctata tcataatatg tacatttata ttggctcatg tccaatatga     7680

ccgccatg                                                              7688


<210>  31
<211>  7548
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pHybE-D2-hCg1,z,a 

<400>  31
agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga       60

gaagttgggg ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa      120

ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta      180

tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca      240

ggtaagtgcc gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt      300

gccttgaatt acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg      360

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      420

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      480

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      540

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      600

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      660

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      720

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      780

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      840

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      900

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      960

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     1020

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     1080

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     1140

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag gaattctcta     1200

gagatccctc gacctcgaga tccattgtgc ccgggcgcca ccatggagtt tgggctgagc     1260

tggctttttc ttgtcgcgat tttaaaaggt gtccagtgtg aggtgcagct ggtggagtct     1320

gggggaggct tggtacagcc cggcaggtcc ctgagactct cctgtgcggc ctctggattc     1380

acctttgatg attatgccat gcactgggtc cggcaagctc cagggaaggg cctggaatgg     1440

gtctcagcta tcacttggaa tagtggtcac atagactatg cggactctgt ggagggccga     1500

ttcaccatct ccagagacaa cgccaagaac tccctgtatc tgcaaatgaa cagtctgaga     1560

gctgaggata cggccgtata ttactgtgcg aaagtctcgt accttagcac cgcgtcctcc     1620

cttgactatt ggggccaagg taccctggtc accgtctcga gtgcgtcgac caagggccca     1680

tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc     1740

tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg     1800

accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc     1860

agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat     1920

cacaagccca gcaacaccaa ggtggacaag aaagttgagc ccaaatcttg tgacaaaact     1980

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc     2040

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg     2100

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     2160

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     2220

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     2280

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     2340

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     2400

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     2460

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     2520

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     2580

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     2640

tctccgggta aataagcggc cgctcgaggc cggcaaggcc ggatcccccg acctcgacct     2700

ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct     2760

cactcggaag gacatatggg agggcaaatc atttggtcga gatccctcgg agatctctag     2820

ctagaggatc gatccccgcc ccggacgaac taaacctgac tacgacatct ctgccccttc     2880

ttcgcggggc agtgcatgta atcccttcag ttggttggta caacttgcca actgggccct     2940

gttccacatg tgacacgggg ggggaccaaa cacaaagggg ttctctgact gtagttgaca     3000

tccttataaa tggatgtgca catttgccaa cactgagtgg ctttcatcct ggagcagact     3060

ttgcagtctg tggactgcaa cacaacattg cctttatgtg taactcttgg ctgaagctct     3120

tacaccaatg ctgggggaca tgtacctccc aggggcccag gaagactacg ggaggctaca     3180

ccaacgtcaa tcagaggggc ctgtgtagct accgataagc ggaccctcaa gagggcatta     3240

gcaatagtgt ttataaggcc cccttgttaa ccctaaacgg gtagcatatg cttcccgggt     3300

agtagtatat actatccaga ctaaccctaa ttcaatagca tatgttaccc aacgggaagc     3360

atatgctatc gaattagggt tagtaaaagg gtcctaagga acagcgatat ctcccacccc     3420

atgagctgtc acggttttat ttacatgggg tcaggattcc acgagggtag tgaaccattt     3480

tagtcacaag ggcagtggct gaagatcaag gagcgggcag tgaactctcc tgaatcttcg     3540

cctgcttctt cattctcctt cgtttagcta atagaataac tgctgagttg tgaacagtaa     3600

ggtgtatgtg aggtgctcga aaacaaggtt tcaggtgacg cccccagaat aaaatttgga     3660

cggggggttc agtggtggca ttgtgctatg acaccaatat aaccctcaca aaccccttgg     3720

gcaataaata ctagtgtagg aatgaaacat tctgaatatc tttaacaata gaaatccatg     3780

gggtggggac aagccgtaaa gactggatgt ccatctcaca cgaatttatg gctatgggca     3840

acacataatc ctagtgcaat atgatactgg ggttattaag atgtgtccca ggcagggacc     3900

aagacaggtg aaccatgttg ttacactcta tttgtaacaa ggggaaagag agtggacgcc     3960

gacagcagcg gactccactg gttgtctcta acacccccga aaattaaacg gggctccacg     4020

ccaatggggc ccataaacaa agacaagtgg ccactctttt ttttgaaatt gtggagtggg     4080

ggcacgcgtc agcccccaca cgccgccctg cggttttgga ctgtaaaata agggtgtaat     4140

aacttggctg attgtaaccc cgctaaccac tgcggtcaaa ccacttgccc acaaaaccac     4200

taatggcacc ccggggaata cctgcataag taggtgggcg ggccaagata ggggcgcgat     4260

tgctgcgatc tggaggacaa attacacaca cttgcgcctg agcgccaagc acagggttgt     4320

tggtcctcat attcacgagg tcgctgagag cacggtgggc taatgttgcc atgggtagca     4380

tatactaccc aaatatctgg atagcatatg ctatcctaat ctatatctgg gtagcatagg     4440

ctatcctaat ctatatctgg gtagcatatg ctatcctaat ctatatctgg gtagtatatg     4500

ctatcctaat ttatatctgg gtagcatagg ctatcctaat ctatatctgg gtagcatatg     4560

ctatcctaat ctatatctgg gtagtatatg ctatcctaat ctgtatccgg gtagcatatg     4620

ctatcctaat agagattagg gtagtatatg ctatcctaat ttatatctgg gtagcatata     4680

ctacccaaat atctggatag catatgctat cctaatctat atctgggtag catatgctat     4740

cctaatctat atctgggtag cataggctat cctaatctat atctgggtag catatgctat     4800

cctaatctat atctgggtag tatatgctat cctaatttat atctgggtag cataggctat     4860

cctaatctat atctgggtag catatgctat cctaatctat atctgggtag tatatgctat     4920

cctaatctgt atccgggtag catatgctat cctcatgata agctgtcaaa catgagaatt     4980

ttcttgaaga cgaaagggcc tcgtgatacg cctattttta taggttaatg tcatgataat     5040

aatggtttct tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg     5100

tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat     5160

gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat     5220

tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt     5280

aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag     5340

cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa     5400

agttctgcta tgtggcgcgg tattatcccg tgttgacgcc gggcaagagc aactcggtcg     5460

ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct     5520

tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac     5580

tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca     5640

caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat     5700

accaaacgac gagcgtgaca ccacgatgcc tgcagcaatg gcaacaacgt tgcgcaaact     5760

attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc     5820

ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga     5880

taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg     5940

taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg     6000

aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca     6060

agtttactca tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta     6120

ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca     6180

ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg     6240

cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga     6300

tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa     6360

tactgttctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc     6420

tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg     6480

tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac     6540

ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct     6600

acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc     6660

ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg     6720

gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg     6780

ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct     6840

ggccttttgc tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga     6900

taaccgtatt accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg     6960

cagcgagtca gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc     7020

gcgttggccg attcattaat gcagctggca cgacaggttt cccgactgga aagcgggcag     7080

tgagcgcaac gcaattaatg tgagttagct cactcattag gcaccccagg ctttacactt     7140

tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc acacaggaaa     7200

cagctatgac catgattacg ccaagctcta gctagaggtc gagtccctcc ccagcaggca     7260

gaagtatgca aagcatgcat ctcaattagt cagcaaccat agtcccgccc ctaactccgc     7320

ccatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc tgactaattt     7380

tttttattta tgcagaggcc gaggccgcct cggcctctga gctattccag aagtagtgag     7440

gaggcttttt tggaggccta ggcttttgca aaaagctttg caaagatgga taaagtttta     7500

aacagagagg aatctttgca gctaatggac cttctaggtc ttgaaagg                  7548


<210>  32
<211>  6845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pHybE-E7-hCk 

<400>  32
agctttgcaa agatggataa agttttaaac agagaggaat ctttgcagct aatggacctt       60

ctaggtcttg aaaggagtgg gaattggctc cggtgcccgt cagtgggcag agcgcacatc      120

gcccacagtc cccgagaagt tggggggagg ggtcggcaat tgaaccggtg cctagagaag      180

gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg      240

tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt      300

tgccgccaga acacaggtaa gtgccgtgtg tggttcccgc gggcctggcc tctttacggg      360

ttatggccct tgcgtgcctt gaattacttc cacctggctg cagtacgtga ttcttgatcc      420

cgagcttcgg gttggaagtg ggtgggagag ttcgaggcct tgcgcttaag gagccccttc      480

gcctcgtgct tgagttgagg cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg      540

gcaccttcgc gcctgtctcg ctgctttcga taagtctcta gccatttaaa atttttgatg      600

acctgctgcg acgctttttt tctggcaaga tagtcttgta aatgcgggcc aagatctgca      660

cactggtatt tcggtttttg gggccgcggg cggcgacggg gcccgtgcgt cccagcgcac      720

atgttcggcg aggcggggcc tgcgagcgcg gccaccgaga atcggacggg ggtagtctca      780

agctggccgg cctgctctgg tgcctggcct cgcgccgccg tgtatcgccc cgccctgggc      840

ggcaaggctg gcccggtcgg caccagttgc gtgagcggaa agatggccgc ttcccggccc      900

tgctgcaggg agctcaaaat ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc      960

cacacaaagg aaaagggcct ttccgtcctc agccgtcgct tcatgtgact ccacggagta     1020

ccgggcgccg tccaggcacc tcgattagtt ctcgagcttt tggagtacgt cgtctttagg     1080

ttggggggag gggttttatg cgatggagtt tccccacact gagtgggtgg agactgaagt     1140

taggccagct tggcacttga tgtaattctc cttggaattt gccctttttg agtttggatc     1200

ttggttcatt ctcaagcctc agacagtggt tcaaagtttt tttcttccat ttcaggtgtc     1260

gtgaggaatt ctctagagat ccctcgacct cgagatccat tgtgcccggg cgcaccatgg     1320

acatgcgcgt gcccgcccag ctgctgggcc tgctgctgct gtggttcccc ggctcgcgat     1380

gcgacatcca gatgacccag tctccatcct ccctgtctgc atctgtaggg gacagagtca     1440

ccatcacttg tcgggcaagt cagggcatca gaaattactt agcctggtat cagcaaaaac     1500

cagggaaagc ccctaagctc ctgatctatg ctgcatccac tttgcaatca ggggtcccat     1560

ctcggttcag tggcagtgga tctgggacag atttcactct caccatcagc agcctacagc     1620

ctgaagatgt tgcaacttat tactgtcaaa ggtataaccg tgcaccgtat acttttggcc     1680

aggggaccaa ggtggaaatc aaacgtacgg tggctgcacc atctgtcttc atcttcccgc     1740

catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg aataacttct     1800

atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg ggtaactccc     1860

aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc agcaccctga     1920

cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc acccatcagg     1980

gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttgagcg gccgctcgag     2040

gccggcaagg ccggatcccc cgacctcgac ctctggctaa taaaggaaat ttattttcat     2100

tgcaatagtg tgttggaatt ttttgtgtct ctcactcgga aggacatatg ggagggcaaa     2160

tcatttggtc gagatccctc ggagatctct agctagagga tcgatccccg ccccggacga     2220

actaaacctg actacgacat ctctgcccct tcttcgcggg gcagtgcatg taatcccttc     2280

agttggttgg tacaacttgc caactgggcc ctgttccaca tgtgacacgg ggggggacca     2340

aacacaaagg ggttctctga ctgtagttga catccttata aatggatgtg cacatttgcc     2400

aacactgagt ggctttcatc ctggagcaga ctttgcagtc tgtggactgc aacacaacat     2460

tgcctttatg tgtaactctt ggctgaagct cttacaccaa tgctggggga catgtacctc     2520

ccaggggccc aggaagacta cgggaggcta caccaacgtc aatcagaggg gcctgtgtag     2580

ctaccgataa gcggaccctc aagagggcat tagcaatagt gtttataagg cccccttgtt     2640

aaccctaaac gggtagcata tgcttcccgg gtagtagtat atactatcca gactaaccct     2700

aattcaatag catatgttac ccaacgggaa gcatatgcta tcgaattagg gttagtaaaa     2760

gggtcctaag gaacagcgat atctcccacc ccatgagctg tcacggtttt atttacatgg     2820

ggtcaggatt ccacgagggt agtgaaccat tttagtcaca agggcagtgg ctgaagatca     2880

aggagcgggc agtgaactct cctgaatctt cgcctgcttc ttcattctcc ttcgtttagc     2940

taatagaata actgctgagt tgtgaacagt aaggtgtatg tgaggtgctc gaaaacaagg     3000

tttcaggtga cgcccccaga ataaaatttg gacggggggt tcagtggtgg cattgtgcta     3060

tgacaccaat ataaccctca caaacccctt gggcaataaa tactagtgta ggaatgaaac     3120

attctgaata tctttaacaa tagaaatcca tggggtgggg acaagccgta aagactggat     3180

gtccatctca cacgaattta tggctatggg caacacataa tcctagtgca atatgatact     3240

ggggttatta agatgtgtcc caggcaggga ccaagacagg tgaaccatgt tgttacactc     3300

tatttgtaac aaggggaaag agagtggacg ccgacagcag cggactccac tggttgtctc     3360

taacaccccc gaaaattaaa cggggctcca cgccaatggg gcccataaac aaagacaagt     3420

ggccactctt ttttttgaaa ttgtggagtg ggggcacgcg tcagccccca cacgccgccc     3480

tgcggttttg gactgtaaaa taagggtgta ataacttggc tgattgtaac cccgctaacc     3540

actgcggtca aaccacttgc ccacaaaacc actaatggca ccccggggaa tacctgcata     3600

agtaggtggg cgggccaaga taggggcgcg attgctgcga tctggaggac aaattacaca     3660

cacttgcgcc tgagcgccaa gcacagggtt gttggtcctc atattcacga ggtcgctgag     3720

agcacggtgg gctaatgttg ccatgggtag catatactac ccaaatatct ggatagcata     3780

tgctatccta atctatatct gggtagcata ggctatccta atctatatct gggtagcata     3840

tgctatccta atctatatct gggtagtata tgctatccta atttatatct gggtagcata     3900

ggctatccta atctatatct gggtagcata tgctatccta atctatatct gggtagtata     3960

tgctatccta atctgtatcc gggtagcata tgctatccta atagagatta gggtagtata     4020

tgctatccta atttatatct gggtagcata tactacccaa atatctggat agcatatgct     4080

atcctaatct atatctgggt agcatatgct atcctaatct atatctgggt agcataggct     4140

atcctaatct atatctgggt agcatatgct atcctaatct atatctgggt agtatatgct     4200

atcctaattt atatctgggt agcataggct atcctaatct atatctgggt agcatatgct     4260

atcctaatct atatctgggt agtatatgct atcctaatct gtatccgggt agcatatgct     4320

atcctcatga taagctgtca aacatgagaa ttttcttgaa gacgaaaggg cctcgtgata     4380

cgcctatttt tataggttaa tgtcatgata ataatggttt cttagacgtc aggtggcact     4440

tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg     4500

tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt     4560

atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct     4620

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca     4680

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc     4740

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc     4800

cgtgttgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg     4860

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta     4920

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc     4980

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt     5040

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg     5100

cctgcagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct     5160

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc     5220

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct     5280

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac     5340

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc     5400

tcactgatta agcattggta actgtcagac caagtttact catatatact ttagattgat     5460

ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg     5520

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc     5580

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     5640

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     5700

gtaactggct tcagcagagc gcagatacca aatactgttc ttctagtgta gccgtagtta     5760

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     5820

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     5880

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     5940

gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg     6000

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     6060

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     6120

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     6180

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     6240

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct     6300

gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa     6360

gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg     6420

cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa tgtgagttag     6480

ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcgtat gttgtgtgga     6540

attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta cgccaagctc     6600

tagctagagg tcgagtccct ccccagcagg cagaagtatg caaagcatgc atctcaatta     6660

gtcagcaacc atagtcccgc ccctaactcc gcccatcccg cccctaactc cgcccagttc     6720

cgcccattct ccgccccatg gctgactaat tttttttatt tatgcagagg ccgaggccgc     6780

ctcggcctct gagctattcc agaagtagtg aggaggcttt tttggaggcc taggcttttg     6840

caaaa                                                                 6845


