                         SEQUENCE LISTING

<110>  Yale University
       State, Matthew
       O'Roak, Brian
       Lifton, Richard
 
<120>  Mutations in CNTNAP2 are Associated with Increased Risk for 
       Ideopathic Autism

<130>  047162-5040-00-WO

<150>  U.S. 61/010,676
<151>  2008-01-09

<160>  56    

<170>  PatentIn version 3.4

<210>  1
<211>  9890
<212>  DNA
<213>  Homo sapiens

<400>  1
acaagctctc catgtgagct gacaggcgag tggaaacccc tcgagtcacg ctgcccggcg     60

gcggagggag cgctcgcccg cagtggcaac agctgcacca ccgtccccgt cgctctgcct    120

tcctcttctg cagcctctgc tcttctgatt acctccctcc cccgtccttt ggtgattttt    180

ttttttcaag aaggagaggg cggggtaggt gtccgttccc tcccctcttc cccctccttt    240

gccttcttgg tttgaatttc ctcccccggc gttgcactgg cacacagtgc aagaggcaat    300

acccgcacgg agggagaacg aaggctgaga ctcccctgcc gctccaagcc cggaagaact    360

ggagcctgga ggggggtgag gggagaagag gaagcgggag gggcttggct tcctcgcgta    420

tttgaggaca gcccatctcc cttcaagaac cctacggaga gtcggactgc atctccgcag    480

cgagctcttg gagcgccgcc ggccgggagg cgaaggatgc aggcggctcc gcgcgccggc    540

tgcggggcag cgctcctgct gtggattgtc agcagctgcc tctgcagagc ctggacggct    600

ccctccacgt cccaaaaatg tgatgagcca cttgtctctg gactccccca tgtggctttc    660

agcagctcct cctccatctc tggtagctat tctcccggct atgccaagat aaacaagaga    720

ggaggtgctg ggggatggtc tccatcagac agcgaccatt atcaatggct tcaggttgac    780

tttggcaatc ggaagcagat cagtgccatt gcaacccaag gaaggtatag cagctcagat    840

tgggtgaccc aataccggat gctctacagc gacacaggga gaaactggaa accctatcat    900

caagatggga atatctgggc atttcccgga aacattaact ctgacggtgt ggtccggcac    960

gaattacagc atccgattat tgcccgctat gtgcgcatag tgcctctgga ttggaatgga   1020

gaaggtcgca ttggactcag aattgaagtt tatggctgtt cttactgggc tgatgttatc   1080

aactttgatg gccatgttgt attaccatat agattcagaa acaagaagat gaaaacactg   1140

aaagatgtca ttgccttgaa ctttaagacg tctgaaagtg aaggagtaat cctgcacgga   1200

gaaggacagc aaggagatta cattaccttg gaactgaaaa aagccaagct ggtcctcagt   1260

ttaaacttag gaagcaacca gcttggcccc atatatggcc acacatcagt gatgacagga   1320

agtttgctgg atgaccacca ctggcactct gtggtcattg agcgccaggg gcggagcatt   1380

aacctcactc tggacaggag catgcagcac ttccgtacca atggagagtt tgactacctg   1440

gacttggact atgagataac ctttggaggc atccctttct ctggcaagcc cagctccagc   1500

agtagaaaga atttcaaagg ctgcatggaa agcatcaact acaatggcgt caacattact   1560

gatcttgcca gaaggaagaa attagagccc tcaaatgtgg gaaatttgag cttttcttgt   1620

gtggaaccct atacggtgcc tgtctttttc aacgctacaa gttacctgga ggtgcccgga   1680

cggcttaacc aggacctgtt ctcagtcagt ttccagttta ggacatggaa ccccaatggt   1740

ctcctggtct tcagtcactt tgcggataat ttgggcaatg tggagattga cctcactgaa   1800

agcaaagtgg gtgttcacat caacatcaca cagaccaaga tgagccaaat cgatatttcc   1860

tcaggttctg ggttgaatga tggacagtgg cacgaggttc gcttcctagc caaggaaaat   1920

tttgctattc tcaccatcga tggagatgaa gcatcagcag ttcgaactaa tagtcccctt   1980

caagttaaaa ctggcgagaa gtactttttt ggaggttttc tgaaccagat gaataactca   2040

agtcactctg tccttcagcc ttcattccaa ggatgcatgc agctcattca agtggacgat   2100

caacttgtaa atttatacga agtggcacaa aggaagccgg gaagtttcgc gaatgtcagc   2160

attgacatgt gtgcgatcat agacagatgt gtgcccaatc actgtgagca tggtggaaag   2220

tgctcgcaaa catgggacag cttcaaatgc acttgtgatg agacaggata cagtggggcc   2280

acctgccaca actctatcta cgagccttcc tgtgaagcct acaaacacct aggacagaca   2340

tcaaattatt actggataga tcctgatggc agcggacctc tggggcctct gaaagtttac   2400

tgcaacatga cagaggacaa agtgtggacc atagtgtctc atgacttgca gatgcagacg   2460

cctgtggtcg gctacaaccc agaaaaatac tcagtgacac agctcgttta cagcgcctcc   2520

atggaccaga taagtgccat cactgacagt gccgagtact gcgagcagta tgtctcctat   2580

ttctgcaaga tgtcaagatt gttgaacacc ccagatggaa gcccttacac ttggtgggtt   2640

ggcaaagcca acgagaagca ctactactgg ggaggctctg ggcctggaat ccagaaatgt   2700

gcctgcggca tcgaacgcaa ctgcacagat cccaagtact actgtaactg cgacgcggac   2760

tacaagcaat ggaggaagga tgctggtttc ttatcataca aagatcacct gccagtgagc   2820

caagtggtgg ttggagatac tgaccgtcaa ggctcagaag ccaaattgag cgtaggtcct   2880

ctgcgctgcc aaggagacag gaattattgg aatgccgcct ctttcccaaa cccatcctcc   2940

tacctgcact tctctacttt ccaaggggaa actagcgctg acatttcttt ctacttcaaa   3000

acattaaccc cctggggagt gtttcttgaa aatatgggaa aggaagattt catcaagctg   3060

gagctgaagt ctgccacaga agtgtccttt tcatttgatg tgggaaatgg gccagtagag   3120

attgtagtga ggtcaccaac ccctctcaac gatgaccagt ggcaccgggt cactgcagag   3180

aggaatgtca agcaggccag cctacaggtg gaccggctac cgcagcagat ccgcaaggcc   3240

ccaacagaag gccacacccg cctggagctc tacagccagt tatttgtggg tggtgctggg   3300

ggccagcagg gcttcctggg ctgcatccgc tccttgagga tgaatggggt gacacttgac   3360

ctggaggaaa gagcaaaggt cacatctggg ttcatatccg gatgctcggg ccattgcacc   3420

agctatggaa caaactgtga aaatggaggc aaatgcctag agagatacca cggttactcc   3480

tgcgattgct ctaatactgc atatgatgga acattttgca acaaagatgt tggtgcattt   3540

tttgaagaag ggatgtggct acgatataac tttcaggcac cagcaacaaa tgccagagac   3600

tccagcagca gagtagacaa cgctcccgac cagcagaact cccacccgga cctggcacag   3660

gaggagatcc gcttcagctt cagcaccacc aaggcgccct gcattctcct ctacatcagc   3720

tccttcacca cagacttctt ggcagtcctc gtcaaaccca ctggaagctt acagattcga   3780

tacaacctgg gtggcacccg agagccatac aatattgacg tagaccacag gaacatggcc   3840

aatggacagc cccacagtgt caacatcacc cgccacgaga agaccatctt tctcaagctc   3900

gatcattatc cttctgtgag ttaccatctg ccaagttcat ccgacaccct cttcaattct   3960

cccaagtcgc tctttctggg aaaagttata gaaacaggga aaattgacca agagattcac   4020

aaatacaaca ccccaggatt cactggttgc ctctccagag tccagttcaa ccagatcgcc   4080

cctctcaagg ccgccttgag gcagacaaac gcctcggctc acgtccacat ccagggcgag   4140

ctggtggagt ccaactgcgg ggcctcgccg ctgaccctct cccccatgtc gtccgccacc   4200

gacccctggc acctggatca cctggattca gccagtgcgg attttccata taatccagga   4260

caaggccaag ctataagaaa tggagtcaac agaaactcgg ctatcattgg aggcgtcatt   4320

gctgtggtga ttttcaccat cctgtgcacc ctggtcttcc tgatccggta catgttccgc   4380

cacaagggca cctaccatac caacgaagca aagggggcgg agtcggcaga gagcgcggac   4440

gccgccatca tgaacaacga ccccaacttc acagagacca ttgatgaaag caaaaaggaa   4500

tggctcattt gaggggtggc tacttggcta tgggataggg aggagggaat tactagggag   4560

gagagaaagg gacaaaagca ccctgcttca tactcttgag cacatcctta aaatatcagc   4620

acaagttggg ggaggcaggc aatggaatat aatggaatat tcttgagact gatcacaaaa   4680

aaaaaaacct ttttaatatt tctttatagc tgagttttcc cttctgtatc aaaacaaaat   4740

aatacaaaaa atgcttttag agtttaagca atggttgaaa tttgtaggta ctatctgtct   4800

tattttgtgt gtgtttagag gtgttctaaa gacccgtggt aacagggcaa gttttctacg   4860

tttttaagag cccttagaac gtgggtattt tttttcttga gaaaagctaa tgcacctaca   4920

gatggccccc aacattctct tccttttgct tctagtcaac cttaatgggc tgttacagaa   4980

actagttcgt gtttatatac tatttccttt gatgtcctat aagtcggaaa agaaaggggc   5040

aaagagaacc tattatttgc cagtttttaa gcagagctca atctatgcca gctctctggc   5100

atctggggtt cctgactgat accagcagtt gaaggaagag agtgcatggc acctggtgtg   5160

taacgacaca atcagcacaa ctggagagag gcattaaaga accagggaag gtagtttgat   5220

ttttcattga attctacaag ctaatattgt tccacgtatg tagtcttaga ccaatagctg   5280

taactatcag ctgcaatacc atggtgacca gctgttacaa aagatttttt cctgttttat   5340

ctgaaacata ctggatttat atatgtataa gcgcctcaat ggggaattag agccagatgt   5400

tatgatttgt ttgctctttt tcttttatag tttagttata gcaaaaatat ggataatttc   5460

tagtgaatgc ataaattagg ttgcgtttct tattttgctt taaatctctg gtagtttttc   5520

cacccctgtg acacaatcct aatagacagt gtcctgtaaa tggacacaac acaataaagt   5580

caagttatta ttgctgttac tctggatgat atggaaaaca ctgccatatt ttaaatcaac   5640

tactccacgt gtttttccat ccaatcacac tgctgtgatt cagggatctt tcttctaaga   5700

cggacacatt tgaacctcag gttcatcaca aacctggtac ctgttgcttc ccagaggatg   5760

gagaagtgta gttaatcaca cctcttagtt taatctgaaa tcttgaccca gttatttaac   5820

aaataaatac ctcattgatt atatttaaaa gtaatacact tcctgtaaac aaatggggac   5880

aatgcatcca aaaaatcttt ttaaacagat tacacaaaaa ttatttccag aaaggctacc   5940

atttatcatc attatatttc aagcctctta tacttaataa gcactttcta aaaagtcttg   6000

agatcccacc attctgagga attcaatatg atcacttttt ccttctttgc ctgggagagg   6060

ttaagaggag gtttcgaagg tatagatgct attgttctga tggcccggct gaataaaatg   6120

gaaattctag tttgttagaa ttatgcattc tttttcaaga ttctcagtgt gcctaactta   6180

ttggagcaca tcagtttctt gggtaatgga aaacattacc tagagttgcc agtggcacat   6240

tacaccagta cagagcacat tccaaaggag acattggacc agttaattcc catacaagtc   6300

aaggtaacag aacaaaaggg aatcctgatg cccttttacc attgctggtt gagctcaggc   6360

actgtcatgg acacccttaa ttttaaaagg ttttaatcat tcttctataa aatacattta   6420

aaatggaaaa atacttaata tcactaaata tcagaacaat gtaacattta caaatgacat   6480

attgaaagca aaggctgttt tatttagcca agatgattac cattaggagt tactttatgt   6540

attgttgaaa gcaaatttta aacatgatgt tttagaagtg tttctgattt ttaaacctgg   6600

tttacaggta ttacttctgc acttaccaaa taatgccaga tggaaattta ttatttcttg   6660

caattcccat gatagctctg ttctttatgc attgtctcaa cactttccct tttttcccaa   6720

aatgagtaga gaattaaagc cacccaaaac agcttctgct actaaaatgt tctcatcctt   6780

tctcctccct ctccttttcc tgccacaaaa ggtgaaaaat gagatccaat cctctcacca   6840

aaatttcaaa cctaggacac tggaatgact gcagggatca gtggttctcc catatcacca   6900

tcaattaaga catataggac actgtcttcc ttcaagaggg ttacaatgtg gccatcagac   6960

aggaaaccaa acggtggata aagtattaag taactaagtg ccaaataaat gctggaaatc   7020

ttgacctctc cttgggatta tgggtgtaac aaaaatccct acatctgttt atgaaggcca   7080

tattcagtac attttaaatg gtaaataatc tgtttatgtg aagaaaaaga attaagtctt   7140

tcttccaact ctctccttgg atagcctagc acagtgcagc ctccataacc atgacattcc   7200

cgcccaagct ctcagtgcct aatcctgctt tgtcattcac atctcacaaa atcttgacat   7260

cttacattcc aatacattat caagcaagca caagtatgct ggtagtagcc tctttaaata   7320

atatgtatag acaacaacaa cgacaaaaaa tagactgttt taaagtttca gggaaagttg   7380

gtggctgatt taaagttgtg caggaaacat cttctgtgta tgaagcaaat gtcgatgttt   7440

tgaaaaaagc taggagatga ctttgaatga atgcaaggtt agtgagatcc taagctctca   7500

aaatagcata ttccctagag ctcaagaaag ctggtccagg aggttgaaaa agctattttg   7560

ttgttaaatt attttctggc ccttcttaat atttaaaaat gtatttcccc ttgtggcttt   7620

caaccacctg ctcaaaaaaa gagacttgtt acatgaaagt tttcattaaa gagctgaaaa   7680

caagaattta gagagccatt cctagaaaat gtcctactgc cctgcatttg acaaacaagc   7740

atcctttact aacaagagca ggaattcaga ggcacaagaa aaagcattgg catgagccaa   7800

agagtctgtc ttaatgttac ttttgaaaat ctgctgagcg gccaccatat gcaggctgag   7860

agctgggcac aggcgaagcc attggaagca cttcaggaac aagcacacag ctgtgggact   7920

tgaacatgca agtgttcagg ttgtgtcaag aagcttttct ttccttctat gatggaatct   7980

gttcttttct atcctacttt tttctctctt cctctcctca ccacattata ccctgctctt   8040

acgcagtaaa cgttttaatg gcccgtttat gtctcatgcc tccaaacaac actgaatttg   8100

aaacccccca ttttttcttt tcaccaccct gttgagcaat tttcccaaaa aaagggcagc   8160

aattattaaa ttgaattcaa gtaagccagc caaagatagg tcctaaattg ctagtcccag   8220

tagaaccacc tgatcctaaa ccagtgcgaa acaaacagta acaatgtccc cagctgactt   8280

cagctaagaa ccaatggctc ctacccccgc cccgcttttt tttgttgttt tttgttttgt   8340

tttgagacgg agtcttgctc tgtcccccag gctggagtgc actggcgcaa tctcgggctc   8400

actgcaacct cctcctcctc ccacattgag gcgattctcc tgcctcagcc tcccaagtag   8460

ctgggattac aggcacccgc catcacaccc agctaatttt tttttttttt tgtattatta   8520

gtagaagcca ggtttcacca tgttggccag ggtggtctcg aactcctgac ctcaagtgat   8580

ccgtccacct cggccttgca aattgctggg attacaggtg tgagccaccg tgccgagcca   8640

gccccatttt ttaaatgatg ttttggttaa gagtggacca tgagaattag ctgacagcat   8700

cccctttctc tctccctgcc ttggtgggac cctccctgtg tgaccttggt caagtcctcg   8760

aacttttgtc ccgtatttaa gatggagctg ttttacctac ttcataagac agttgcgagg   8820

tgccattgat tcttgactgc aaaatacctt gaaaccctta tataaagact gaagtcaacg   8880

gagcctagtg aaagacttac tttgtggctt gtggttgaaa gtcacatcaa aagacaaatg   8940

tggccacgtt caggaattgg agacttactg gcatggctct acagctgctc agttattaat   9000

catgcagact aacctgtcaa cactgggaga tgcaacatag caaaaggaca gagaaattag   9060

aattttttgt gcagaaagcc ctaaattccc acctgaatgt aacttacagc tcccttacct   9120

actctcacac atgccctcaa acatgctaga ttggcttata cataggccaa cacaaaatac   9180

aaacgtgacg tgttcatgta gcctagtggc tatatgccta ttctccatgt accctgcatg   9240

gtagtgctgc aaactttaaa gtacatttct ttcacagcag tatttttttt cataagtggc   9300

atataaatgt cattcaatga aatggggaaa tcacgttgag aagttggtct gtcatctccc   9360

attgagcaaa gactggcagg agataataaa aataaatatg ggcacacatg tattaatata   9420

cagcacgcat ttacaagttt attttccaga taaaattgtg ctataagaac agctctacca   9480

agacagtctg caccatttcc aagtctcagt taatttacag caactgctgc tttcggagat   9540

ggctgtgaaa atatggaagt tcctctcaag taggccaaga aacagttcta gattttacta   9600

agttttattt tgtcaggttt tttaaatttt ttcagtgagc gtggtgactg cagaggttag   9660

tgctgtgaaa agctgggcta aatattcttt ctgtaaagtc aaacaggatt ccatcccctg   9720

tgaaataaca caaaatttca ctctctaaaa gcaacagcat gtaaactaga atgaaagaag   9780

gaaattatgt acgtatgcct aatattcttt gtgaatgtct ttcatttaac taaaattata   9840

ttagaaacca gattgataaa taaaaaattc aaagtagttt taattatcct              9890


<210>  2
<211>  1331
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Ala Ala Pro Arg Ala Gly Cys Gly Ala Ala Leu Leu Leu Trp 
1               5                   10                  15      


Ile Val Ser Ser Cys Leu Cys Arg Ala Trp Thr Ala Pro Ser Thr Ser 
            20                  25                  30          


Gln Lys Cys Asp Glu Pro Leu Val Ser Gly Leu Pro His Val Ala Phe 
        35                  40                  45              


Ser Ser Ser Ser Ser Ile Ser Gly Ser Tyr Ser Pro Gly Tyr Ala Lys 
    50                  55                  60                  


Ile Asn Lys Arg Gly Gly Ala Gly Gly Trp Ser Pro Ser Asp Ser Asp 
65                  70                  75                  80  


His Tyr Gln Trp Leu Gln Val Asp Phe Gly Asn Arg Lys Gln Ile Ser 
                85                  90                  95      


Ala Ile Ala Thr Gln Gly Arg Tyr Ser Ser Ser Asp Trp Val Thr Gln 
            100                 105                 110         


Tyr Arg Met Leu Tyr Ser Asp Thr Gly Arg Asn Trp Lys Pro Tyr His 
        115                 120                 125             


Gln Asp Gly Asn Ile Trp Ala Phe Pro Gly Asn Ile Asn Ser Asp Gly 
    130                 135                 140                 


Val Val Arg His Glu Leu Gln His Pro Ile Ile Ala Arg Tyr Val Arg 
145                 150                 155                 160 


Ile Val Pro Leu Asp Trp Asn Gly Glu Gly Arg Ile Gly Leu Arg Ile 
                165                 170                 175     


Glu Val Tyr Gly Cys Ser Tyr Trp Ala Asp Val Ile Asn Phe Asp Gly 
            180                 185                 190         


His Val Val Leu Pro Tyr Arg Phe Arg Asn Lys Lys Met Lys Thr Leu 
        195                 200                 205             


Lys Asp Val Ile Ala Leu Asn Phe Lys Thr Ser Glu Ser Glu Gly Val 
    210                 215                 220                 


Ile Leu His Gly Glu Gly Gln Gln Gly Asp Tyr Ile Thr Leu Glu Leu 
225                 230                 235                 240 


Lys Lys Ala Lys Leu Val Leu Ser Leu Asn Leu Gly Ser Asn Gln Leu 
                245                 250                 255     


Gly Pro Ile Tyr Gly His Thr Ser Val Met Thr Gly Ser Leu Leu Asp 
            260                 265                 270         


Asp His His Trp His Ser Val Val Ile Glu Arg Gln Gly Arg Ser Ile 
        275                 280                 285             


Asn Leu Thr Leu Asp Arg Ser Met Gln His Phe Arg Thr Asn Gly Glu 
    290                 295                 300                 


Phe Asp Tyr Leu Asp Leu Asp Tyr Glu Ile Thr Phe Gly Gly Ile Pro 
305                 310                 315                 320 


Phe Ser Gly Lys Pro Ser Ser Ser Ser Arg Lys Asn Phe Lys Gly Cys 
                325                 330                 335     


Met Glu Ser Ile Asn Tyr Asn Gly Val Asn Ile Thr Asp Leu Ala Arg 
            340                 345                 350         


Arg Lys Lys Leu Glu Pro Ser Asn Val Gly Asn Leu Ser Phe Ser Cys 
        355                 360                 365             


Val Glu Pro Tyr Thr Val Pro Val Phe Phe Asn Ala Thr Ser Tyr Leu 
    370                 375                 380                 


Glu Val Pro Gly Arg Leu Asn Gln Asp Leu Phe Ser Val Ser Phe Gln 
385                 390                 395                 400 


Phe Arg Thr Trp Asn Pro Asn Gly Leu Leu Val Phe Ser His Phe Ala 
                405                 410                 415     


Asp Asn Leu Gly Asn Val Glu Ile Asp Leu Thr Glu Ser Lys Val Gly 
            420                 425                 430         


Val His Ile Asn Ile Thr Gln Thr Lys Met Ser Gln Ile Asp Ile Ser 
        435                 440                 445             


Ser Gly Ser Gly Leu Asn Asp Gly Gln Trp His Glu Val Arg Phe Leu 
    450                 455                 460                 


Ala Lys Glu Asn Phe Ala Ile Leu Thr Ile Asp Gly Asp Glu Ala Ser 
465                 470                 475                 480 


Ala Val Arg Thr Asn Ser Pro Leu Gln Val Lys Thr Gly Glu Lys Tyr 
                485                 490                 495     


Phe Phe Gly Gly Phe Leu Asn Gln Met Asn Asn Ser Ser His Ser Val 
            500                 505                 510         


Leu Gln Pro Ser Phe Gln Gly Cys Met Gln Leu Ile Gln Val Asp Asp 
        515                 520                 525             


Gln Leu Val Asn Leu Tyr Glu Val Ala Gln Arg Lys Pro Gly Ser Phe 
    530                 535                 540                 


Ala Asn Val Ser Ile Asp Met Cys Ala Ile Ile Asp Arg Cys Val Pro 
545                 550                 555                 560 


Asn His Cys Glu His Gly Gly Lys Cys Ser Gln Thr Trp Asp Ser Phe 
                565                 570                 575     


Lys Cys Thr Cys Asp Glu Thr Gly Tyr Ser Gly Ala Thr Cys His Asn 
            580                 585                 590         


Ser Ile Tyr Glu Pro Ser Cys Glu Ala Tyr Lys His Leu Gly Gln Thr 
        595                 600                 605             


Ser Asn Tyr Tyr Trp Ile Asp Pro Asp Gly Ser Gly Pro Leu Gly Pro 
    610                 615                 620                 


Leu Lys Val Tyr Cys Asn Met Thr Glu Asp Lys Val Trp Thr Ile Val 
625                 630                 635                 640 


Ser His Asp Leu Gln Met Gln Thr Pro Val Val Gly Tyr Asn Pro Glu 
                645                 650                 655     


Lys Tyr Ser Val Thr Gln Leu Val Tyr Ser Ala Ser Met Asp Gln Ile 
            660                 665                 670         


Ser Ala Ile Thr Asp Ser Ala Glu Tyr Cys Glu Gln Tyr Val Ser Tyr 
        675                 680                 685             


Phe Cys Lys Met Ser Arg Leu Leu Asn Thr Pro Asp Gly Ser Pro Tyr 
    690                 695                 700                 


Thr Trp Trp Val Gly Lys Ala Asn Glu Lys His Tyr Tyr Trp Gly Gly 
705                 710                 715                 720 


Ser Gly Pro Gly Ile Gln Lys Cys Ala Cys Gly Ile Glu Arg Asn Cys 
                725                 730                 735     


Thr Asp Pro Lys Tyr Tyr Cys Asn Cys Asp Ala Asp Tyr Lys Gln Trp 
            740                 745                 750         


Arg Lys Asp Ala Gly Phe Leu Ser Tyr Lys Asp His Leu Pro Val Ser 
        755                 760                 765             


Gln Val Val Val Gly Asp Thr Asp Arg Gln Gly Ser Glu Ala Lys Leu 
    770                 775                 780                 


Ser Val Gly Pro Leu Arg Cys Gln Gly Asp Arg Asn Tyr Trp Asn Ala 
785                 790                 795                 800 


Ala Ser Phe Pro Asn Pro Ser Ser Tyr Leu His Phe Ser Thr Phe Gln 
                805                 810                 815     


Gly Glu Thr Ser Ala Asp Ile Ser Phe Tyr Phe Lys Thr Leu Thr Pro 
            820                 825                 830         


Trp Gly Val Phe Leu Glu Asn Met Gly Lys Glu Asp Phe Ile Lys Leu 
        835                 840                 845             


Glu Leu Lys Ser Ala Thr Glu Val Ser Phe Ser Phe Asp Val Gly Asn 
    850                 855                 860                 


Gly Pro Val Glu Ile Val Val Arg Ser Pro Thr Pro Leu Asn Asp Asp 
865                 870                 875                 880 


Gln Trp His Arg Val Thr Ala Glu Arg Asn Val Lys Gln Ala Ser Leu 
                885                 890                 895     


Gln Val Asp Arg Leu Pro Gln Gln Ile Arg Lys Ala Pro Thr Glu Gly 
            900                 905                 910         


His Thr Arg Leu Glu Leu Tyr Ser Gln Leu Phe Val Gly Gly Ala Gly 
        915                 920                 925             


Gly Gln Gln Gly Phe Leu Gly Cys Ile Arg Ser Leu Arg Met Asn Gly 
    930                 935                 940                 


Val Thr Leu Asp Leu Glu Glu Arg Ala Lys Val Thr Ser Gly Phe Ile 
945                 950                 955                 960 


Ser Gly Cys Ser Gly His Cys Thr Ser Tyr Gly Thr Asn Cys Glu Asn 
                965                 970                 975     


Gly Gly Lys Cys Leu Glu Arg Tyr His Gly Tyr Ser Cys Asp Cys Ser 
            980                 985                 990         


Asn Thr Ala Tyr Asp Gly Thr Phe  Cys Asn Lys Asp Val  Gly Ala Phe 
        995                 1000                 1005             


Phe Glu  Glu Gly Met Trp Leu  Arg Tyr Asn Phe Gln  Ala Pro Ala 
    1010                 1015                 1020             


Thr Asn  Ala Arg Asp Ser Ser  Ser Arg Val Asp Asn  Ala Pro Asp 
    1025                 1030                 1035             


Gln Gln  Asn Ser His Pro Asp  Leu Ala Gln Glu Glu  Ile Arg Phe 
    1040                 1045                 1050             


Ser Phe  Ser Thr Thr Lys Ala  Pro Cys Ile Leu Leu  Tyr Ile Ser 
    1055                 1060                 1065             


Ser Phe  Thr Thr Asp Phe Leu  Ala Val Leu Val Lys  Pro Thr Gly 
    1070                 1075                 1080             


Ser Leu  Gln Ile Arg Tyr Asn  Leu Gly Gly Thr Arg  Glu Pro Tyr 
    1085                 1090                 1095             


Asn Ile  Asp Val Asp His Arg  Asn Met Ala Asn Gly  Gln Pro His 
    1100                 1105                 1110             


Ser Val  Asn Ile Thr Arg His  Glu Lys Thr Ile Phe  Leu Lys Leu 
    1115                 1120                 1125             


Asp His  Tyr Pro Ser Val Ser  Tyr His Leu Pro Ser  Ser Ser Asp 
    1130                 1135                 1140             


Thr Leu  Phe Asn Ser Pro Lys  Ser Leu Phe Leu Gly  Lys Val Ile 
    1145                 1150                 1155             


Glu Thr  Gly Lys Ile Asp Gln  Glu Ile His Lys Tyr  Asn Thr Pro 
    1160                 1165                 1170             


Gly Phe  Thr Gly Cys Leu Ser  Arg Val Gln Phe Asn  Gln Ile Ala 
    1175                 1180                 1185             


Pro Leu  Lys Ala Ala Leu Arg  Gln Thr Asn Ala Ser  Ala His Val 
    1190                 1195                 1200             


His Ile  Gln Gly Glu Leu Val  Glu Ser Asn Cys Gly  Ala Ser Pro 
    1205                 1210                 1215             


Leu Thr  Leu Ser Pro Met Ser  Ser Ala Thr Asp Pro  Trp His Leu 
    1220                 1225                 1230             


Asp His  Leu Asp Ser Ala Ser  Ala Asp Phe Pro Tyr  Asn Pro Gly 
    1235                 1240                 1245             


Gln Gly  Gln Ala Ile Arg Asn  Gly Val Asn Arg Asn  Ser Ala Ile 
    1250                 1255                 1260             


Ile Gly  Gly Val Ile Ala Val  Val Ile Phe Thr Ile  Leu Cys Thr 
    1265                 1270                 1275             


Leu Val  Phe Leu Ile Arg Tyr  Met Phe Arg His Lys  Gly Thr Tyr 
    1280                 1285                 1290             


His Thr  Asn Glu Ala Lys Gly  Ala Glu Ser Ala Glu  Ser Ala Asp 
    1295                 1300                 1305             


Ala Ala  Ile Met Asn Asn Asp  Pro Asn Phe Thr Glu  Thr Ile Asp 
    1310                 1315                 1320             


Glu Ser  Lys Lys Glu Trp Leu  Ile 
    1325                 1330     


<210>  3
<211>  6426
<212>  DNA
<213>  Homo sapiens

<400>  3
gggagctgcg ctcgcagttt cgccctctct tccgctaatg attgcattat tatgctcccc     60

tctctggggg gtctcgcccc tcttgggtcg ctccggagcc ccggcctccc ctggctgcat    120

ttcttaaaaa tttgggagcc tgggagtgag ttttctccga ggcgtgtgtg agaggcggcg    180

ggggtgtttt cctgcgcgag gggcgggtga agttcattgc ccccactttt cccgcgacct    240

ttttcggacc cgattttgga tcgagttgag gggggcgcgg gcgttttcgg ggggcggggg    300

gcgcggcgga gaatggccgc ggggagggct ccccggagcc tcccagtctc ttgatcaaag    360

cattccgcta ttctgattta ttgcttgctt ggtgagttat ttttttttcc tctaaaggag    420

acctgtgtgt tcagccatta ctttgctcgg cgctgctccc aggcatctcc gaccctcggt    480

gctgtgggga gccccacact tgggctcctc gcctctcgcc ctcgctcccc gtccctcctc    540

ccctctctcc gccccttccc ccttttcttt ctcctctctt tcttcccctc tctcccttct    600

ttcggccgcc gtctcccccg cgccctcctc ggggcggagg gaagccgtga agggggaggg    660

agggctcggt gtcaattttt ttttgtgtgg ctgcggccgt agcctgtggc gggcaagcgg    720

ggagaccccg gcgcagcaga accatggatg gcccgacgcg gggccatgga ctccgcaaaa    780

agcggcggtc gcggtcgcag cgagaccggg agaggcgctc ccggggcggg ctgggggccg    840

gcgcggccgg cggcggcggg gctggccgga cccgggcgct ctcactcgcc tcgtcgtcgg    900

gctccgacaa ggaagacaat gggaagcccc cgtcctccgc cccgtcccgg cccagacccc    960

cgcggaggaa gcggagagag tccacctcgg cagaagagga catcattgat ggatttgcca   1020

tgaccagctt tgtcactttt gaagcgctgg agaaagatgt agcacttaag cctcaggaac   1080

gtgtggagaa acgccagacg cccctgacca agaagaaacg agaagcactt accaatggct   1140

tgtcctttca ttcaaagaag agcagactca gccacccaca ccactacagc tcagatcgag   1200

aaaatgaccg caatctctgc cagcaccttg ggaagagaaa gaaaatgccg aaggcactca   1260

gacagctcaa gccaggacag aacagctgca gggacagtga cagtgaaagt gccagtggag   1320

aatccaaggg cttccaccgg agcagctctc gggaaaggct cagtgatagt tcagctcctt   1380

ccagcttggg aacaggctac ttctgtgaca gtgacagtga ccaggaagag aaggcatcag   1440

atgccagctc tgaaaaactc ttcaacactg ttattgtaaa caaagatccg gagttaggtg   1500

ttggcacgct accagaacat gacagccagg atgcagggcc gattgtcccc aagatatcgg   1560

gtctagagag aagccaggag aagagccagg actgttgcaa agagccaatc tttgagcctg   1620

tggtgcttaa agacccctgc cctcaggtcg cacagccaat accccagccg cagacggagc   1680

cccaactccg agctccttct ccggaccctg acttggtgca gcgcacagag gccccacctc   1740

aacccccacc tctgagtaca cagccaccac agggccctcc tgaggcccag ctccagcctg   1800

ccccgcagcc tcaggtgcag aggccaccca ggccacagtc ccccacccag ctgctccatc   1860

agaacctccc acctgtgcag gcccacccct ctgctcagag cctctcccag ccattgtcag   1920

cctacaacag cagtagctta agcctcaaca gtttaagcag cagcagaagc agcactccag   1980

cgaagactca gcccgcccca cctcacatct cccaccaccc ctctgcctcc ccgttccccc   2040

tctccctgcc caaccacagc cccctgcaca gcttcacacc caccctccag ccccccgcac   2100

actcacatca ccccaatatg tttgcccctc ccactgctct gcctcctcca ccaccactga   2160

catcaggaag tctgcaggtg gccggacacc cggccgggag cacttactca gagcaagaca   2220

tcttgcgaca ggaactgaac actcgttttt tggcctctca gagtgctgac cgcggggctt   2280

ccctgggccc tccgccctac ctgcggaccg agttccatca gcaccagcac cagcaccagc   2340

acacccacca gcacacgcac cagcacacct tcacgccgtt cccccacgcc atcccaccca   2400

ccgccatcat gccgacgcca gcacctccca tgtttgacaa ataccctaca aaagttgacc   2460

cattctaccg gcacagtctc ttccattcct atcctcctgc agtgtcgggc atccccccta   2520

tgatcccacc cactggccct tttggttcac tacaaggagc atttcagccg aagacatcca   2580

accctatcga tgtcgctgct cggcctggga cagtcccaca cactttactc caaaaggacc   2640

cgaggttgac agatcctttc agacctatgt taaggaaacc agggaagtgg tgtgctatgc   2700

atgttcacat cgcctggcag atttaccacc accaacagaa agtcaagaaa cagatgcagt   2760

cagacccaca taagctggac tttggactga aacctgagtt cctgagccgc cctccaggcc   2820

ccagtctttt tggagccatc caccaccccc atgacctggc acggccttca actttgttct   2880

ctgccgctgg tgctgcacac ccaactggga ccccttttgg gccacctcct catcacagca   2940

acttcctcaa ccctgctgcc cacctagagc cttttaatcg gccgtctaca ttcacaggcc   3000

tagcagcagt tggtggcaat gccttcgggg gacttggaaa tccttccgtt acacccaact   3060

caatgttcgg ccacaaggat ggccccagtg tgcagaactt tagcaaccct cacgaaccct   3120

ggaaccggct gcaccgaacg cctccgtcgt tcccgacccc tccgccctgg ctgaagccag   3180

gggagctgga gcgcagcgcg tccgctgcag ctcatgacag agatagagat gtagataaac   3240

gagactcatc tgttagtaaa gatgacaaag aaagggaaag cgtcgagaag agacactcca   3300

gccacccttc accagcacct gtcctcccgg tgaatgccct gggacatacc cgcagctcca   3360

ctgaacagat ccgggctcat ctgaacactg aggctcggga gaaggacaaa cccaaagaga   3420

gggagagaga ccactcggaa tcccgcaagg acctggccgc cgacgagcac aaggcgaaag   3480

agggccacct gcccgagaag gacgggcacg gccacgaggg gcgcgccgcg ggcgaagagg   3540

ccaagcagct ggcccgggtg ccgtctccct acgtgcggac cccggtggtg gagagtgcca   3600

ggcccaacag cacctcgagc cgggaggccg agccgcgcaa gggtgagccg gcctacgaga   3660

accccaagaa gagctccgag gtcaaggtga aggaggagcg gaaggaagac catgacctgc   3720

ctccagaggc cccgcagacc caccgggcct cggagccgcc gcctcccaac tcctcgtcca   3780

gcgtgcaccc ggggcccctg gcctcgatgc ccatgacggt gggggtgacg ggcattcacc   3840

ccatgaacag catcagcagc ctggacagga ctcgcatgat gacccccttc atgggcatca   3900

gccccctccc gggcggagag cgcttcccgt acccttcttt ccactgggac cccatccggg   3960

accccttgag ggatccttac cgagaacttg acattcaccg gagagacccg ctgggcaggg   4020

acttcctgct aaggaacgac ccgctccacc ggctctcgac tccccggctg tacgaagccg   4080

accgctcctt cagggaccgg gagcctcacg actacagcca ccaccaccac caccaccacc   4140

acccgctgtc tgtggaccct cggcgggagc acgagcgggg aggccacctg gacgagcggg   4200

agcgcttgca catgctcaga gaagactacg agcacacgcg gctccactcc gtgcaccccg   4260

cctccctcga cggacacctc ccccacccca gcctcatcac cccgggactc cccagcatgc   4320

actatccccg catcagcccc accgcgggca accagaacgg actcctcaac aagacccctc   4380

cgacagcagc gctgagcgca cctcccccgc tcatctccac gctggggggc cgcccggtct   4440

ctcccagaag gacgactcct ctgtccgcag agataaggga gaggccccct tcccacacgc   4500

tgaaggatat cgaggcccga taagccgaga acaggagcaa gaacgaggaa gaagaaaccc   4560

taggcagaca ccaggccagg cttgagagac agaactcctg catggctcac acagactggg   4620

ggggaaagcc ccaccccttc cccttgtaaa aaatgtatag actcagtgca cattttgaaa   4680

tgttttgtat attatatgtt gagatttttc agatctttta gcccagtcat atgttctcac   4740

gtctcctact ttttgtttct cgtataaaac tttttgattt gaaccaaaac agtgaagatg   4800

acaacacaca ccaattggat gataattgta gcgggggcgg tgggggggag aagtccacgc   4860

catccatcat gcaaaattct ttcagatgag gtgggaaggc cgtgtacata gttatgtaaa   4920

aagagattgc ttcatgagct aatggttcat atatgcaaaa gggtaagatg aaagctttac   4980

tttgtacaaa tgtaaataga taaagtaaca taatacatta atacttctta aaatgtgcta   5040

tttgcaaact tacttaatat cagtgaacac agtcggctaa agctgtgttc ccatatattg   5100

ttatagacag ctaaaccctt caactatgca atgaatgttc gggcttttca caaaagcccg   5160

cctaactcaa aggagccttt tcaaatccat ttacagcata cttaaggtca tattttccct   5220

gaacaagcgc ttacgtgata tgactctgtt ttccttgctt gttttttttc aaacggagaa   5280

acatcctgtt ttgcaaattg gaccccaggc tggaacttag catctgaagt tgccgcttgt   5340

gggctctggg ggaaagtgta gccccggaga ggtaactgag gacatgagca accagtgcca   5400

gggagggtgg gatttgccag atgccaaaat caggggacgg gtggtggtgt ctgtcagaca   5460

cacacaggtc gccagtgact tcacacacac ctcatgtgag aaccatgcct tttttagtgt   5520

gtcctatttc atacctgtac acacttcctc gttttgtaat gagatttact tacacccaaa   5580

cagatcctga aagaaagctt caagttttct cagatgatgg atatgttttc actgtattca   5640

ataactgacg gatgtaaggt gcacgtttcc tgatgtgacg cactgtattc cagctggtga   5700

tcaagtctgg gaacagccgt aacaggtcaa ccttgtggag ccatcgcgag ttagagggtg   5760

aaagatggca gaaaaaaaag tcttgtgtgt gagtgtgttt tttgagtttg catcaatctt   5820

aatgtctctt cataatactt ttataataca ttaagcctct tgtctacata tttggagaga   5880

atatgacttt actagcagag aaatacaata tatcttgtct actggactgt aaaatatatg   5940

tatgaaataa aattagttcc atttggtctt ctagtatatt aaagtgctat ctgacgttgt   6000

tatcctgttt ttgcaaaaaa aaaaaaaaaa aaaagttaac tacagaccat tgtttctaat   6060

aagcagagag atctatttta gtagtaaact gaaggtttag ttgtgagctt cagattttgt   6120

gaactccaga tgttgtgcgg tgtttttttt tttttttaag acaacaacta aaaaaaatgc   6180

aaggaatatg tacactggaa ctgtagtggt agctttcagt attgtaaaga gattgttcta   6240

tacggacctt tttgctgttt atcctgtatg taataaagtc ctttctagat cctatgtgaa   6300

aagaaaagtg aagcaactga atcttcagca tgttctcatc ggcggagcct tcttgtgtaa   6360

tgtaaactgt gccatgttat taaaaaatgt gaactaagct tccagctgct tgtttgtgtg   6420

aggtga                                                              6426


<210>  4
<211>  1259
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Gly Pro Thr Arg Gly His Gly Leu Arg Lys Lys Arg Arg Ser 
1               5                   10                  15      


Arg Ser Gln Arg Asp Arg Glu Arg Arg Ser Arg Gly Gly Leu Gly Ala 
            20                  25                  30          


Gly Ala Ala Gly Gly Gly Gly Ala Gly Arg Thr Arg Ala Leu Ser Leu 
        35                  40                  45              


Ala Ser Ser Ser Gly Ser Asp Lys Glu Asp Asn Gly Lys Pro Pro Ser 
    50                  55                  60                  


Ser Ala Pro Ser Arg Pro Arg Pro Pro Arg Arg Lys Arg Arg Glu Ser 
65                  70                  75                  80  


Thr Ser Ala Glu Glu Asp Ile Ile Asp Gly Phe Ala Met Thr Ser Phe 
                85                  90                  95      


Val Thr Phe Glu Ala Leu Glu Lys Asp Val Ala Leu Lys Pro Gln Glu 
            100                 105                 110         


Arg Val Glu Lys Arg Gln Thr Pro Leu Thr Lys Lys Lys Arg Glu Ala 
        115                 120                 125             


Leu Thr Asn Gly Leu Ser Phe His Ser Lys Lys Ser Arg Leu Ser His 
    130                 135                 140                 


Pro His His Tyr Ser Ser Asp Arg Glu Asn Asp Arg Asn Leu Cys Gln 
145                 150                 155                 160 


His Leu Gly Lys Arg Lys Lys Met Pro Lys Ala Leu Arg Gln Leu Lys 
                165                 170                 175     


Pro Gly Gln Asn Ser Cys Arg Asp Ser Asp Ser Glu Ser Ala Ser Gly 
            180                 185                 190         


Glu Ser Lys Gly Phe His Arg Ser Ser Ser Arg Glu Arg Leu Ser Asp 
        195                 200                 205             


Ser Ser Ala Pro Ser Ser Leu Gly Thr Gly Tyr Phe Cys Asp Ser Asp 
    210                 215                 220                 


Ser Asp Gln Glu Glu Lys Ala Ser Asp Ala Ser Ser Glu Lys Leu Phe 
225                 230                 235                 240 


Asn Thr Val Ile Val Asn Lys Asp Pro Glu Leu Gly Val Gly Thr Leu 
                245                 250                 255     


Pro Glu His Asp Ser Gln Asp Ala Gly Pro Ile Val Pro Lys Ile Ser 
            260                 265                 270         


Gly Leu Glu Arg Ser Gln Glu Lys Ser Gln Asp Cys Cys Lys Glu Pro 
        275                 280                 285             


Ile Phe Glu Pro Val Val Leu Lys Asp Pro Cys Pro Gln Val Ala Gln 
    290                 295                 300                 


Pro Ile Pro Gln Pro Gln Thr Glu Pro Gln Leu Arg Ala Pro Ser Pro 
305                 310                 315                 320 


Asp Pro Asp Leu Val Gln Arg Thr Glu Ala Pro Pro Gln Pro Pro Pro 
                325                 330                 335     


Leu Ser Thr Gln Pro Pro Gln Gly Pro Pro Glu Ala Gln Leu Gln Pro 
            340                 345                 350         


Ala Pro Gln Pro Gln Val Gln Arg Pro Pro Arg Pro Gln Ser Pro Thr 
        355                 360                 365             


Gln Leu Leu His Gln Asn Leu Pro Pro Val Gln Ala His Pro Ser Ala 
    370                 375                 380                 


Gln Ser Leu Ser Gln Pro Leu Ser Ala Tyr Asn Ser Ser Ser Leu Ser 
385                 390                 395                 400 


Leu Asn Ser Leu Ser Ser Ser Arg Ser Ser Thr Pro Ala Lys Thr Gln 
                405                 410                 415     


Pro Ala Pro Pro His Ile Ser His His Pro Ser Ala Ser Pro Phe Pro 
            420                 425                 430         


Leu Ser Leu Pro Asn His Ser Pro Leu His Ser Phe Thr Pro Thr Leu 
        435                 440                 445             


Gln Pro Pro Ala His Ser His His Pro Asn Met Phe Ala Pro Pro Thr 
    450                 455                 460                 


Ala Leu Pro Pro Pro Pro Pro Leu Thr Ser Gly Ser Leu Gln Val Ala 
465                 470                 475                 480 


Gly His Pro Ala Gly Ser Thr Tyr Ser Glu Gln Asp Ile Leu Arg Gln 
                485                 490                 495     


Glu Leu Asn Thr Arg Phe Leu Ala Ser Gln Ser Ala Asp Arg Gly Ala 
            500                 505                 510         


Ser Leu Gly Pro Pro Pro Tyr Leu Arg Thr Glu Phe His Gln His Gln 
        515                 520                 525             


His Gln His Gln His Thr His Gln His Thr His Gln His Thr Phe Thr 
    530                 535                 540                 


Pro Phe Pro His Ala Ile Pro Pro Thr Ala Ile Met Pro Thr Pro Ala 
545                 550                 555                 560 


Pro Pro Met Phe Asp Lys Tyr Pro Thr Lys Val Asp Pro Phe Tyr Arg 
                565                 570                 575     


His Ser Leu Phe His Ser Tyr Pro Pro Ala Val Ser Gly Ile Pro Pro 
            580                 585                 590         


Met Ile Pro Pro Thr Gly Pro Phe Gly Ser Leu Gln Gly Ala Phe Gln 
        595                 600                 605             


Pro Lys Thr Ser Asn Pro Ile Asp Val Ala Ala Arg Pro Gly Thr Val 
    610                 615                 620                 


Pro His Thr Leu Leu Gln Lys Asp Pro Arg Leu Thr Asp Pro Phe Arg 
625                 630                 635                 640 


Pro Met Leu Arg Lys Pro Gly Lys Trp Cys Ala Met His Val His Ile 
                645                 650                 655     


Ala Trp Gln Ile Tyr His His Gln Gln Lys Val Lys Lys Gln Met Gln 
            660                 665                 670         


Ser Asp Pro His Lys Leu Asp Phe Gly Leu Lys Pro Glu Phe Leu Ser 
        675                 680                 685             


Arg Pro Pro Gly Pro Ser Leu Phe Gly Ala Ile His His Pro His Asp 
    690                 695                 700                 


Leu Ala Arg Pro Ser Thr Leu Phe Ser Ala Ala Gly Ala Ala His Pro 
705                 710                 715                 720 


Thr Gly Thr Pro Phe Gly Pro Pro Pro His His Ser Asn Phe Leu Asn 
                725                 730                 735     


Pro Ala Ala His Leu Glu Pro Phe Asn Arg Pro Ser Thr Phe Thr Gly 
            740                 745                 750         


Leu Ala Ala Val Gly Gly Asn Ala Phe Gly Gly Leu Gly Asn Pro Ser 
        755                 760                 765             


Val Thr Pro Asn Ser Met Phe Gly His Lys Asp Gly Pro Ser Val Gln 
    770                 775                 780                 


Asn Phe Ser Asn Pro His Glu Pro Trp Asn Arg Leu His Arg Thr Pro 
785                 790                 795                 800 


Pro Ser Phe Pro Thr Pro Pro Pro Trp Leu Lys Pro Gly Glu Leu Glu 
                805                 810                 815     


Arg Ser Ala Ser Ala Ala Ala His Asp Arg Asp Arg Asp Val Asp Lys 
            820                 825                 830         


Arg Asp Ser Ser Val Ser Lys Asp Asp Lys Glu Arg Glu Ser Val Glu 
        835                 840                 845             


Lys Arg His Ser Ser His Pro Ser Pro Ala Pro Val Leu Pro Val Asn 
    850                 855                 860                 


Ala Leu Gly His Thr Arg Ser Ser Thr Glu Gln Ile Arg Ala His Leu 
865                 870                 875                 880 


Asn Thr Glu Ala Arg Glu Lys Asp Lys Pro Lys Glu Arg Glu Arg Asp 
                885                 890                 895     


His Ser Glu Ser Arg Lys Asp Leu Ala Ala Asp Glu His Lys Ala Lys 
            900                 905                 910         


Glu Gly His Leu Pro Glu Lys Asp Gly His Gly His Glu Gly Arg Ala 
        915                 920                 925             


Ala Gly Glu Glu Ala Lys Gln Leu Ala Arg Val Pro Ser Pro Tyr Val 
    930                 935                 940                 


Arg Thr Pro Val Val Glu Ser Ala Arg Pro Asn Ser Thr Ser Ser Arg 
945                 950                 955                 960 


Glu Ala Glu Pro Arg Lys Gly Glu Pro Ala Tyr Glu Asn Pro Lys Lys 
                965                 970                 975     


Ser Ser Glu Val Lys Val Lys Glu Glu Arg Lys Glu Asp His Asp Leu 
            980                 985                 990         


Pro Pro Glu Ala Pro Gln Thr His  Arg Ala Ser Glu Pro  Pro Pro Pro 
        995                 1000                 1005             


Asn Ser  Ser Ser Ser Val His  Pro Gly Pro Leu Ala  Ser Met Pro 
    1010                 1015                 1020             


Met Thr  Val Gly Val Thr Gly  Ile His Pro Met Asn  Ser Ile Ser 
    1025                 1030                 1035             


Ser Leu  Asp Arg Thr Arg Met  Met Thr Pro Phe Met  Gly Ile Ser 
    1040                 1045                 1050             


Pro Leu  Pro Gly Gly Glu Arg  Phe Pro Tyr Pro Ser  Phe His Trp 
    1055                 1060                 1065             


Asp Pro  Ile Arg Asp Pro Leu  Arg Asp Pro Tyr Arg  Glu Leu Asp 
    1070                 1075                 1080             


Ile His  Arg Arg Asp Pro Leu  Gly Arg Asp Phe Leu  Leu Arg Asn 
    1085                 1090                 1095             


Asp Pro  Leu His Arg Leu Ser  Thr Pro Arg Leu Tyr  Glu Ala Asp 
    1100                 1105                 1110             


Arg Ser  Phe Arg Asp Arg Glu  Pro His Asp Tyr Ser  His His His 
    1115                 1120                 1125             


His His  His His His Pro Leu  Ser Val Asp Pro Arg  Arg Glu His 
    1130                 1135                 1140             


Glu Arg  Gly Gly His Leu Asp  Glu Arg Glu Arg Leu  His Met Leu 
    1145                 1150                 1155             


Arg Glu  Asp Tyr Glu His Thr  Arg Leu His Ser Val  His Pro Ala 
    1160                 1165                 1170             


Ser Leu  Asp Gly His Leu Pro  His Pro Ser Leu Ile  Thr Pro Gly 
    1175                 1180                 1185             


Leu Pro  Ser Met His Tyr Pro  Arg Ile Ser Pro Thr  Ala Gly Asn 
    1190                 1195                 1200             


Gln Asn  Gly Leu Leu Asn Lys  Thr Pro Pro Thr Ala  Ala Leu Ser 
    1205                 1210                 1215             


Ala Pro  Pro Pro Leu Ile Ser  Thr Leu Gly Gly Arg  Pro Val Ser 
    1220                 1225                 1230             


Pro Arg  Arg Thr Thr Pro Leu  Ser Ala Glu Ile Arg  Glu Arg Pro 
    1235                 1240                 1245             


Pro Ser  His Thr Leu Lys Asp  Ile Glu Ala Arg 
    1250                 1255                 


<210>  5
<211>  5952
<212>  DNA
<213>  Homo sapiens

<400>  5
cgctcgcagt ttcgccctct cttccgctaa tgattgcatt attatgctcc cctctctggg     60

gggtctcgcc cctcttgggt cgctccggag ccccggcctc ccctggctgc atttcttaaa    120

aatttgggag cctgggagtg agttttctcc gaggcgtgtg tgagaggcgg cgggggtgtt    180

ttcctgcgcg aggggcgggt gaagttcatt gcccccactt ttcccgcgac ctttttcgga    240

cccgattttg gatcgagttg aggggggcgc gggcgttttc ggggggcggg gggcgcggcg    300

gagaatggcc gcggggaggg ctccccggag cctcccagtc tcttgatcaa agcattccgc    360

tattctgatt tattgcttgc ttggtgagtt attttttttt cctctaaagg agacctgtgt    420

gttcagccat tactttgctc ggcgctgctc ccaggcatct ccgaccctcg gtgctgtggg    480

gagccccaca cttgggctcc tcgcctctcg ccctcgctcc ccgtccctcc tcccctctct    540

ccgccccttc ccccttttct ttctcctctc tttcttcccc tctctccctt ctttcggccg    600

ccgtctcccc cgcgccctcc tcggggcgga gggaagccgt gaagggggag ggagggctcg    660

gtgtcaattt ttttttgtgt ggctgcggcc gtagcctgtg gcgggcaagc ggggagaccc    720

cggcgcagca gaaccatgga tggcccgacg cggggccatg gactccgcaa aaagcggcgg    780

tcgcggtcgc agcgagaccg ggagaggcgc tcccggggcg ggctgggggc cggcgcggcc    840

ggcggcggcg gggctggccg gacccgggcg ctctcactcg cctcgtcgtc gggctccgac    900

aaggaagaca atgggaagcc cccgtcctcc gccccgtccc ggcccagacc cccgcggagg    960

aagcggagag agtccacctc ggcagaagag gacatcattg atggatttgc catgaccagc   1020

tttgtcactt ttgaagcgct ggagaaagat gtagcactta agcctcagga acgtgtggag   1080

aaacgccaga cgcccctgac caagaagaaa cgagaagcac ttaccaatgg cttgtccttt   1140

cattcaaaga agagcagact cagccaccca caccactaca gctcagatcg agaaaatgac   1200

cgcaatctct gccagcacct tgggaagaga aagaaaatgc cgaaggcact cagacagctc   1260

aagccaggac agaacagctg cagggacagt gacagtgaaa gtgccagtgg agaatccaag   1320

ggcttccacc ggagcagctc tcgggaaagg ctcagtgata gttcagctcc ttccagcttg   1380

ggaacaggct acttctgtga cagtgacagt gaccaggaag agaaggcatc agatgccagc   1440

tctgaaaaac tcttcaacac tgttattgta aacaaagatc cggagttagg tgttggcacg   1500

ctaccagaac atgacagcca ggatgcaggg ccgattgtcc ccaagatatc gggtctagag   1560

agaagccagg agaagagcca ggactgttgc aaagagccaa tctttgagcc tgtggtgctt   1620

aaagacccct gccctcaggt cgcacagcca ataccccagc cgcagacgga gccccaactc   1680

cgagctcctt ctccggaccc tgacttggtg cagcgcacag aggccccacc tcaaccccca   1740

cctctgagta cacagccacc acagggccct cctgaggccc agctccagcc tgccccgcag   1800

cctcaggtgc agaggccacc caggccacag tcccccaccc agctgctcca tcagaacctc   1860

ccacctgtgc aggcccaccc ctctgctcag agcctctccc agccattgtc agcctacaac   1920

agcagtagct taagcctcaa cagtttaagc agcagcagaa gcagcactcc agcgaagact   1980

cagcccgccc cacctcacat ctcccaccac ccctctgcct ccccgttccc cctctccctg   2040

cccaaccaca gccccctgca cagcttcaca cccaccctcc agccccccgc acactcacat   2100

caccccaata tgtttgcccc tcccactgct ctgcctcctc caccaccact gacatcagga   2160

agtctgcagg tggccggaca cccggccggg agcacttact cagagcaaga catcttgcga   2220

caggaactga acactcgttt tttggcctct cagagtgctg accgcggggc ttccctgggc   2280

cctccgccct acctgcggac cgagttccat cagcaccagc accagcacca gcacacccac   2340

cagcacacgc accagcacac cttcacgccg ttcccccacg ccatcccacc caccgccatc   2400

atgccgacgc cagcacctcc catgtttgac aaatacccta caaaagttga cccattctac   2460

cggcacagtc tcttccattc ctatcctcct gcagtgtcgg gcatcccccc tatgatccca   2520

cccactggcc cttttggttc actacaagga gcatttcagc cgaagttgac agatcctttc   2580

agacctatgt taaggaaacc agggaagtgg tgtgctatgc atgttcacat cgcctggcag   2640

atttaccacc accaacagaa agtcaagaaa cagatgcagt cagacccaca taagctggac   2700

tttggactga aacctgagtt cctgagccgc cctccaggcc ccagtctttt tggagccatc   2760

caccaccccc atgacctggc acggccttca actttgttct ctgccgctgg tgctgcacac   2820

ccaactggga ccccttttgg gccacctcct catcacagca acttcctcaa ccctgctgcc   2880

cacctagagc cttttaatcg gccgtctaca ttcacaggcc tagcagcagt tggtggcaat   2940

gccttcgggg gacttggaaa tccttccgtt acacccaact caatgttcgg ccacaaggat   3000

ggccccagtg tgcagaactt tagcaaccct cacgaaccct ggaaccggct gcaccgaacg   3060

cctccgtcgt tcccgacccc tccgccctgg ctgaagccag gggagctgga gcgcagcgcg   3120

tccgctgcag ctcatgacag agatagagat gtagataaac gagactcatc tgttagtaaa   3180

gatgacaaag aaagggaaag cgtcgagaag agacactcca gccacccttc accagcacct   3240

gtcctcccgg tgaatgccct gggacatacc cgcagctcca ctgaacagat ccgggctcat   3300

ctgaacactg aggctcggga gaaggacaaa cccaaagaga gggagagaga ccactcggaa   3360

tcccgcaagg acctggccgc cgacgagcac aaggcgaaag agggccacct gcccgagaag   3420

gacgggcacg gccacgaggg gcgcgccgcg ggcgaagagg ccaagcagct ggcccgggtg   3480

ccgtctccct acgtgcggac cccggtggtg gagagtgcca ggcccaacag cacctcgagc   3540

cgggaggccg agccgcgcaa gggtgagccg gcctacgaga accccaagaa gagctccgag   3600

gtcaaggtga aggaggagcg gaaggaagac catgacctgc ctccagaggc cccgcagacc   3660

caccgggcct cggagccgcc gcctcccaac tcctcgtcca gcgtgcaccc ggggcccctg   3720

gcctcgatgc ccatgacggt gggggtgacg ggcattcacc ccatgaacag catcagcagc   3780

ctggacagga ctcgcatgat gacccccttc atgggcatca gccccctccc gggcggagag   3840

cgcttcccgt acccttcttt ccactgggac cccatccggg accccttgag ggatccttac   3900

cgagaacttg acattcaccg gagagacccg ctgggcaggg acttcctgct aaggaacgac   3960

ccgctccacc ggctctcgac tccccggctg tacgaagccg accgctcctt cagggaccgg   4020

gagcctcacg actacagcca ccaccaccac caccaccacc acccgctgtc tgtggaccct   4080

cggcgggagc acgagcgggg aggccacctg gacgagcggg agcgcttgca catgctcaga   4140

gaagactacg agcacacgcg gctccactcc gtgcaccccg cctccctcga cggacacctc   4200

ccccacccca gcctcatcac cccgggactc cccagcatgc actatccccg catcagcccc   4260

accgcgggca accagaacgg actcctcaac aagacccctc cgacagcagc gctgagcgca   4320

cctcccccgc tcatctccac gctggggggc cgcccggtct ctcccagaag gacgactcct   4380

ctgtccgcag agataaggga gaggccccct tcccacacgc tgaaggatat cgaggcccga   4440

taagccgaga acaggagcaa gaacgaggaa gaagaaaccc taggcagaca ccaggccagg   4500

cttgagagac agaactcctg catggctcac acagactggg ggggaaagcc ccaccccttc   4560

cccttgtaaa aaatgtatag actcagtgca cattttgaaa tgttttgtat attatatgtt   4620

gagatttttc agatctttta gcccagtcat atgttctcac gtctcctact ttttgtttct   4680

cgtataaaac tttttgattt gaaccaaaac agtgaagatg acaacacaca ccaattggat   4740

gataattgta gcgggggcgg tgggggggag aagtccacgc catccatcat gcaaaattct   4800

ttcagatgag gtgggaaggc cgtgtacata gttatgtaaa aagagattgc ttcatgagct   4860

aatggttcat atatgcaaaa gggtaagatg aaagctttac tttgtacaaa tgtaaataga   4920

taaagtaaca taatacatta atacttctta aaatgtgcta tttgcaaact tacttaatat   4980

cagtgaacac agtcggctaa agctgtgttc ccatatattg ttatagacag ctaaaccctt   5040

caactatgca atgaatgttc gggcttttca caaaagcccg cctaactcaa aggagccttt   5100

tcaaatccat ttacagcata cttaaggtca tattttccct gaacaagcgc ttacgtgata   5160

tgactctgtt ttccttgctt gttttttttc aaacggagaa acatcctgtt ttgcaaattg   5220

gaccccaggc tggaacttag catctgaagt tgccgcttgt gggctctggg ggaaagtgta   5280

gccccggaga ggtaactgag gacatgagca accagtgcca gggagggtgg gatttgccag   5340

atgccaaaat caggggacgg gtggtggtgt ctgtcagaca cacacaggtc gccagtgact   5400

tcacacacac ctcatgtgag aaccatgcct tttttagtgt gtcctatttc atacctgtac   5460

acacttcctc gttttgtaat gagatttact tacacccaaa cagatcctga aagaaagctt   5520

caagttttct cagatgatgg atatgttttc actgtattca ataactgacg gatgtaaggt   5580

gcacgtttcc tgatgtgacg cactgtattc cagctggtga tcaagtctgg gaacagccgt   5640

aacaggtcaa ccttgtggag ccatcgcgag ttagagggtg aaagatggca gaaaaaaaag   5700

tcttgtgtgt gagtgtgttt tttgagtttg catcaatctt aatgtctctt cataatactt   5760

ttataataca ttaagcctct tgtctacata tttggagaga atatgacttt actagcagag   5820

aaatacaata tatcttgtct actggactgt aaaatatatg tatgaaataa aattagttcc   5880

atttggtctt ctagtatatt aaagtgctat ctgacgttgt tatcctgttt ttgcaaaaaa   5940

aaaaaaaaaa aa                                                       5952


<210>  6
<211>  1235
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Gly Pro Thr Arg Gly His Gly Leu Arg Lys Lys Arg Arg Ser 
1               5                   10                  15      


Arg Ser Gln Arg Asp Arg Glu Arg Arg Ser Arg Gly Gly Leu Gly Ala 
            20                  25                  30          


Gly Ala Ala Gly Gly Gly Gly Ala Gly Arg Thr Arg Ala Leu Ser Leu 
        35                  40                  45              


Ala Ser Ser Ser Gly Ser Asp Lys Glu Asp Asn Gly Lys Pro Pro Ser 
    50                  55                  60                  


Ser Ala Pro Ser Arg Pro Arg Pro Pro Arg Arg Lys Arg Arg Glu Ser 
65                  70                  75                  80  


Thr Ser Ala Glu Glu Asp Ile Ile Asp Gly Phe Ala Met Thr Ser Phe 
                85                  90                  95      


Val Thr Phe Glu Ala Leu Glu Lys Asp Val Ala Leu Lys Pro Gln Glu 
            100                 105                 110         


Arg Val Glu Lys Arg Gln Thr Pro Leu Thr Lys Lys Lys Arg Glu Ala 
        115                 120                 125             


Leu Thr Asn Gly Leu Ser Phe His Ser Lys Lys Ser Arg Leu Ser His 
    130                 135                 140                 


Pro His His Tyr Ser Ser Asp Arg Glu Asn Asp Arg Asn Leu Cys Gln 
145                 150                 155                 160 


His Leu Gly Lys Arg Lys Lys Met Pro Lys Ala Leu Arg Gln Leu Lys 
                165                 170                 175     


Pro Gly Gln Asn Ser Cys Arg Asp Ser Asp Ser Glu Ser Ala Ser Gly 
            180                 185                 190         


Glu Ser Lys Gly Phe His Arg Ser Ser Ser Arg Glu Arg Leu Ser Asp 
        195                 200                 205             


Ser Ser Ala Pro Ser Ser Leu Gly Thr Gly Tyr Phe Cys Asp Ser Asp 
    210                 215                 220                 


Ser Asp Gln Glu Glu Lys Ala Ser Asp Ala Ser Ser Glu Lys Leu Phe 
225                 230                 235                 240 


Asn Thr Val Ile Val Asn Lys Asp Pro Glu Leu Gly Val Gly Thr Leu 
                245                 250                 255     


Pro Glu His Asp Ser Gln Asp Ala Gly Pro Ile Val Pro Lys Ile Ser 
            260                 265                 270         


Gly Leu Glu Arg Ser Gln Glu Lys Ser Gln Asp Cys Cys Lys Glu Pro 
        275                 280                 285             


Ile Phe Glu Pro Val Val Leu Lys Asp Pro Cys Pro Gln Val Ala Gln 
    290                 295                 300                 


Pro Ile Pro Gln Pro Gln Thr Glu Pro Gln Leu Arg Ala Pro Ser Pro 
305                 310                 315                 320 


Asp Pro Asp Leu Val Gln Arg Thr Glu Ala Pro Pro Gln Pro Pro Pro 
                325                 330                 335     


Leu Ser Thr Gln Pro Pro Gln Gly Pro Pro Glu Ala Gln Leu Gln Pro 
            340                 345                 350         


Ala Pro Gln Pro Gln Val Gln Arg Pro Pro Arg Pro Gln Ser Pro Thr 
        355                 360                 365             


Gln Leu Leu His Gln Asn Leu Pro Pro Val Gln Ala His Pro Ser Ala 
    370                 375                 380                 


Gln Ser Leu Ser Gln Pro Leu Ser Ala Tyr Asn Ser Ser Ser Leu Ser 
385                 390                 395                 400 


Leu Asn Ser Leu Ser Ser Ser Arg Ser Ser Thr Pro Ala Lys Thr Gln 
                405                 410                 415     


Pro Ala Pro Pro His Ile Ser His His Pro Ser Ala Ser Pro Phe Pro 
            420                 425                 430         


Leu Ser Leu Pro Asn His Ser Pro Leu His Ser Phe Thr Pro Thr Leu 
        435                 440                 445             


Gln Pro Pro Ala His Ser His His Pro Asn Met Phe Ala Pro Pro Thr 
    450                 455                 460                 


Ala Leu Pro Pro Pro Pro Pro Leu Thr Ser Gly Ser Leu Gln Val Ala 
465                 470                 475                 480 


Gly His Pro Ala Gly Ser Thr Tyr Ser Glu Gln Asp Ile Leu Arg Gln 
                485                 490                 495     


Glu Leu Asn Thr Arg Phe Leu Ala Ser Gln Ser Ala Asp Arg Gly Ala 
            500                 505                 510         


Ser Leu Gly Pro Pro Pro Tyr Leu Arg Thr Glu Phe His Gln His Gln 
        515                 520                 525             


His Gln His Gln His Thr His Gln His Thr His Gln His Thr Phe Thr 
    530                 535                 540                 


Pro Phe Pro His Ala Ile Pro Pro Thr Ala Ile Met Pro Thr Pro Ala 
545                 550                 555                 560 


Pro Pro Met Phe Asp Lys Tyr Pro Thr Lys Val Asp Pro Phe Tyr Arg 
                565                 570                 575     


His Ser Leu Phe His Ser Tyr Pro Pro Ala Val Ser Gly Ile Pro Pro 
            580                 585                 590         


Met Ile Pro Pro Thr Gly Pro Phe Gly Ser Leu Gln Gly Ala Phe Gln 
        595                 600                 605             


Pro Lys Leu Thr Asp Pro Phe Arg Pro Met Leu Arg Lys Pro Gly Lys 
    610                 615                 620                 


Trp Cys Ala Met His Val His Ile Ala Trp Gln Ile Tyr His His Gln 
625                 630                 635                 640 


Gln Lys Val Lys Lys Gln Met Gln Ser Asp Pro His Lys Leu Asp Phe 
                645                 650                 655     


Gly Leu Lys Pro Glu Phe Leu Ser Arg Pro Pro Gly Pro Ser Leu Phe 
            660                 665                 670         


Gly Ala Ile His His Pro His Asp Leu Ala Arg Pro Ser Thr Leu Phe 
        675                 680                 685             


Ser Ala Ala Gly Ala Ala His Pro Thr Gly Thr Pro Phe Gly Pro Pro 
    690                 695                 700                 


Pro His His Ser Asn Phe Leu Asn Pro Ala Ala His Leu Glu Pro Phe 
705                 710                 715                 720 


Asn Arg Pro Ser Thr Phe Thr Gly Leu Ala Ala Val Gly Gly Asn Ala 
                725                 730                 735     


Phe Gly Gly Leu Gly Asn Pro Ser Val Thr Pro Asn Ser Met Phe Gly 
            740                 745                 750         


His Lys Asp Gly Pro Ser Val Gln Asn Phe Ser Asn Pro His Glu Pro 
        755                 760                 765             


Trp Asn Arg Leu His Arg Thr Pro Pro Ser Phe Pro Thr Pro Pro Pro 
    770                 775                 780                 


Trp Leu Lys Pro Gly Glu Leu Glu Arg Ser Ala Ser Ala Ala Ala His 
785                 790                 795                 800 


Asp Arg Asp Arg Asp Val Asp Lys Arg Asp Ser Ser Val Ser Lys Asp 
                805                 810                 815     


Asp Lys Glu Arg Glu Ser Val Glu Lys Arg His Ser Ser His Pro Ser 
            820                 825                 830         


Pro Ala Pro Val Leu Pro Val Asn Ala Leu Gly His Thr Arg Ser Ser 
        835                 840                 845             


Thr Glu Gln Ile Arg Ala His Leu Asn Thr Glu Ala Arg Glu Lys Asp 
    850                 855                 860                 


Lys Pro Lys Glu Arg Glu Arg Asp His Ser Glu Ser Arg Lys Asp Leu 
865                 870                 875                 880 


Ala Ala Asp Glu His Lys Ala Lys Glu Gly His Leu Pro Glu Lys Asp 
                885                 890                 895     


Gly His Gly His Glu Gly Arg Ala Ala Gly Glu Glu Ala Lys Gln Leu 
            900                 905                 910         


Ala Arg Val Pro Ser Pro Tyr Val Arg Thr Pro Val Val Glu Ser Ala 
        915                 920                 925             


Arg Pro Asn Ser Thr Ser Ser Arg Glu Ala Glu Pro Arg Lys Gly Glu 
    930                 935                 940                 


Pro Ala Tyr Glu Asn Pro Lys Lys Ser Ser Glu Val Lys Val Lys Glu 
945                 950                 955                 960 


Glu Arg Lys Glu Asp His Asp Leu Pro Pro Glu Ala Pro Gln Thr His 
                965                 970                 975     


Arg Ala Ser Glu Pro Pro Pro Pro Asn Ser Ser Ser Ser Val His Pro 
            980                 985                 990         


Gly Pro Leu Ala Ser Met Pro Met  Thr Val Gly Val Thr  Gly Ile His 
        995                 1000                 1005             


Pro Met  Asn Ser Ile Ser Ser  Leu Asp Arg Thr Arg  Met Met Thr 
    1010                 1015                 1020             


Pro Phe  Met Gly Ile Ser Pro  Leu Pro Gly Gly Glu  Arg Phe Pro 
    1025                 1030                 1035             


Tyr Pro  Ser Phe His Trp Asp  Pro Ile Arg Asp Pro  Leu Arg Asp 
    1040                 1045                 1050             


Pro Tyr  Arg Glu Leu Asp Ile  His Arg Arg Asp Pro  Leu Gly Arg 
    1055                 1060                 1065             


Asp Phe  Leu Leu Arg Asn Asp  Pro Leu His Arg Leu  Ser Thr Pro 
    1070                 1075                 1080             


Arg Leu  Tyr Glu Ala Asp Arg  Ser Phe Arg Asp Arg  Glu Pro His 
    1085                 1090                 1095             


Asp Tyr  Ser His His His His  His His His His Pro  Leu Ser Val 
    1100                 1105                 1110             


Asp Pro  Arg Arg Glu His Glu  Arg Gly Gly His Leu  Asp Glu Arg 
    1115                 1120                 1125             


Glu Arg  Leu His Met Leu Arg  Glu Asp Tyr Glu His  Thr Arg Leu 
    1130                 1135                 1140             


His Ser  Val His Pro Ala Ser  Leu Asp Gly His Leu  Pro His Pro 
    1145                 1150                 1155             


Ser Leu  Ile Thr Pro Gly Leu  Pro Ser Met His Tyr  Pro Arg Ile 
    1160                 1165                 1170             


Ser Pro  Thr Ala Gly Asn Gln  Asn Gly Leu Leu Asn  Lys Thr Pro 
    1175                 1180                 1185             


Pro Thr  Ala Ala Leu Ser Ala  Pro Pro Pro Leu Ile  Ser Thr Leu 
    1190                 1195                 1200             


Gly Gly  Arg Pro Val Ser Pro  Arg Arg Thr Thr Pro  Leu Ser Ala 
    1205                 1210                 1215             


Glu Ile  Arg Glu Arg Pro Pro  Ser His Thr Leu Lys  Asp Ile Glu 
    1220                 1225                 1230             


Ala Arg  
    1235 


<210>  7
<211>  1678
<212>  DNA
<213>  Homo sapiens

<400>  7
gggagctgcg ctcgcagttt cgccctctct tccgctaatg attgcattat tatgctcccc     60

tctctggggg gtctcgcccc tcttgggtcg ctccggagcc ccggcctccc ctggctgcat    120

ttcttaaaaa tttgggagcc tgggagtgag ttttctccga ggcgtgtgtg agaggcggcg    180

ggggtgtttt cctgcgcgag gggcgggtga agttcattgc ccccactttt cccgcgacct    240

ttttcggacc cgattttgga tcgagttgag gggggcgcgg gcgttttcgg ggggcggggg    300

gcgcggcgga gaatggccgc ggggagggct ccccggagcc tcccagtctc ttgatcaaag    360

cattccgcta ttctgattta ttgcttgctt ggtgagttat ttttttttcc tctaaaggag    420

acctgtgtgt tcagccatta ctttgctcgg cgctgctccc aggcatctcc gaccctcggt    480

gctgtgggga gccccacact tgggctcctc gcctctcgcc ctcgctcccc gtccctcctc    540

ccctctctcc gccccttccc ccttttcttt ctcctctctt tcttcccctc tctcccttct    600

ttcggccgcc gtctcccccg cgccctcctc ggggcggagg gaagccgtga agggggaggg    660

agggctcggt gtcaattttt ttttgtgtgg ctgcggccgt agcctgtggc gggcaagcgg    720

ggagaccccg gcgcagcaga accatggatg gcccgacgcg gggccatgga ctccgcaaaa    780

agcggcggtc gcggtcgcag cgagaccggg agaggcgctc ccggggcggg ctgggggccg    840

gcgcggccgg cggcggcggg gctggccgga cccgggcgct ctcactcgcc tcgtcgtcgg    900

gctccgacaa ggaagacaat gggaagcccc cgtcctccgc cccgtcccgg cccagacccc    960

cgcggaggaa gcggagagag tccacctcgg cagaagagga catcattgat ggatttgcca   1020

tgaccagctt tgtcactttt gaagcgctgg agaaagatgt agcacttaag cctcaggaac   1080

gtgtggagaa acgccagacg cccctgacca agaagaaacg agaagcactt accaatggct   1140

tgtcctttca ttcaaagaag agcagactca gccacccaca ccactacagc tcagatcgag   1200

aaaatgaccg caatctctgc cagcaccttg ggaagagaaa gaaaatgccg aaggcactca   1260

gacagctcaa gccaggacag aacagctgca gggacagtga cagtgaaagt gccagtggag   1320

aatccaaggg cttccaccgg agcagctctc gggaaaggct cagtgatagt tcagctcctt   1380

ccagcttggg aacaggctac ttcagatcag ggaagatgtg ccttggagag gaagcatgtc   1440

ttaaatctgg aaatgatatg aagagggatg tcagcaacac ttcatcctgg gccagtaata   1500

gggagagttt cttttctctc gtcaaattgc ttaaaggatt ctagttccgt ttggtgtggt   1560

cactcacatt tgaattctaa tactctatgt gatatagatt ctgttgacta ctgttagcgt   1620

gaccccaatg agaaattaaa cacttccctc cttttcaaaa aaaaaaaaaa aaaaaaaa     1678


<210>  8
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Gly Pro Thr Arg Gly His Gly Leu Arg Lys Lys Arg Arg Ser 
1               5                   10                  15      


Arg Ser Gln Arg Asp Arg Glu Arg Arg Ser Arg Gly Gly Leu Gly Ala 
            20                  25                  30          


Gly Ala Ala Gly Gly Gly Gly Ala Gly Arg Thr Arg Ala Leu Ser Leu 
        35                  40                  45              


Ala Ser Ser Ser Gly Ser Asp Lys Glu Asp Asn Gly Lys Pro Pro Ser 
    50                  55                  60                  


Ser Ala Pro Ser Arg Pro Arg Pro Pro Arg Arg Lys Arg Arg Glu Ser 
65                  70                  75                  80  


Thr Ser Ala Glu Glu Asp Ile Ile Asp Gly Phe Ala Met Thr Ser Phe 
                85                  90                  95      


Val Thr Phe Glu Ala Leu Glu Lys Asp Val Ala Leu Lys Pro Gln Glu 
            100                 105                 110         


Arg Val Glu Lys Arg Gln Thr Pro Leu Thr Lys Lys Lys Arg Glu Ala 
        115                 120                 125             


Leu Thr Asn Gly Leu Ser Phe His Ser Lys Lys Ser Arg Leu Ser His 
    130                 135                 140                 


Pro His His Tyr Ser Ser Asp Arg Glu Asn Asp Arg Asn Leu Cys Gln 
145                 150                 155                 160 


His Leu Gly Lys Arg Lys Lys Met Pro Lys Ala Leu Arg Gln Leu Lys 
                165                 170                 175     


Pro Gly Gln Asn Ser Cys Arg Asp Ser Asp Ser Glu Ser Ala Ser Gly 
            180                 185                 190         


Glu Ser Lys Gly Phe His Arg Ser Ser Ser Arg Glu Arg Leu Ser Asp 
        195                 200                 205             


Ser Ser Ala Pro Ser Ser Leu Gly Thr Gly Tyr Phe Arg Ser Gly Lys 
    210                 215                 220                 


Met Cys Leu Gly Glu Glu Ala Cys Leu Lys Ser Gly Asn Asp Met Lys 
225                 230                 235                 240 


Arg Asp Val Ser Asn Thr Ser Ser Trp Ala Ser Asn Arg Glu Ser Phe 
                245                 250                 255     


Phe Ser Leu Val Lys Leu Leu Lys Gly Phe 
            260                 265     


<210>  9
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  9
cacacagtgc aagaggcaat ac                                              22


<210>  10
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  10
gatgcacttc ggagttgata cc                                              22


<210>  11
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  11
ttaaccaaca cataccaatc gtt                                             23


<210>  12
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  12
gatttctggt gtctgccaac at                                              22


<210>  13
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  13
gaaatagagc actgccaaga cc                                              22


<210>  14
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  14
cattggatag aaattacagc ctga                                            24


<210>  15
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  15
accattggat gacatttgtg tt                                              22


<210>  16
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  16
ggtagtttat tgtcagagaa agcaa                                           25


<210>  17
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  17
catttattct ttgcagacac ctg                                             23


<210>  18
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  18
tttaaagaat tgagcaacat gaaca                                           25


<210>  19
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  19
tatcccaggt taactcgaat gg                                              22


<210>  20
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  20
tcaggttttt aaaattgtca gtgtc                                           25


<210>  21
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  21
attttggagg cagaatgcta taa                                             23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  22
ttttgcccaa acacaaatat gat                                             23


<210>  23
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  23
aggctgtgct tcaaaacttg ta                                              22


<210>  24
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  24
gtaacaccag caaaaccaaa ca                                              22


<210>  25
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  25
aaatcgtgat ttgttgattt tgg                                             23


<210>  26
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  26
tttttgtttt gctcagtgga atta                                            24


<210>  27
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  27
gtagttggat gtgatggctg tg                                              22


<210>  28
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  28
tggtaatttc caccttacct gttt                                            24


<210>  29
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  29
atatattgcc cagacagctt gg                                              22


<210>  30
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  30
ttggtttttc agattcgagt ga                                              22


<210>  31
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  31
ggtttgctag cattgcaata tg                                              22


<210>  32
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  32
gaaacaaacc attggtggaa ct                                              22


<210>  33
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  33
aacactgttc tacaccagct cag                                             23


<210>  34
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  34
tcttagcttc attccccaga aa                                              22


<210>  35
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  35
tcagagtatt cctggggaag tg                                              22


<210>  36
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  36
tttgtcagtt gggttagttc ca                                              22


<210>  37
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  37
tgctatgaga ccacctatgg aa                                              22


<210>  38
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  38
agtctgattg caggcatctt ct                                              22


<210>  39
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  39
gaggatttgg tccaatgttg tt                                              22


<210>  40
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  40
ggcttgtgtg tccacctcta gt                                              22


<210>  41
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  41
attttgccat cgacctttgt ag                                              22


<210>  42
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  42
tgtgcaggct cttaaaaatc aac                                             23


<210>  43
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  43
ctatgcagtg tcatctccta ccac                                            24


<210>  44
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  44
ttggaaaatt cctacctaag ttga                                            24


<210>  45
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  45
acttactcag atgcccttcc tg                                              22


<210>  46
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  46
tggcaagttg ttttcctgat att                                             23


<210>  47
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  47
gacatcaagg gagggagtaa ag                                              22


<210>  48
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  48
ctatcccctc aaaacaaaac ca                                              22


<210>  49
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  49
ggtgttttag agtcagtgct gatg                                            24


<210>  50
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  50
agaacaacca cgtaactttc ctgt                                            24


<210>  51
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  51
tgcagcccta aatcttatcg ac                                              22


<210>  52
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  52
cctgagaact ccgtactcac aa                                              22


<210>  53
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  53
ctgttgtgat tcttgtggga ga                                              22


<210>  54
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  54
cagcaaaatg aataatgtaa aaacc                                           25


<210>  55
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  55
ctgacggagc tgtagtgaag tg                                              22


<210>  56
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  56
cacgggtctt tagaacacct cta                                             23


