                         SEQUENCE LISTING

<110>  Patrys, Ltd
       Hensel, Frank
       Power, Barbara
       Ilag , Leodevico
 
<120>  BARB4 TARGET, ANTIBODY DESIGNATED BARB4, BARB4 RELATED 
       ANTIBODIES, AND METHODS OF MAKING AND USING SAME

<130>  043043-0376930

<140>  PCT/IB2009/005004
<141>  2009-01-07

<150>  61/019,502
<151>  2008-01-07

<150>  61/023,345
<151>  2008-01-24

<150>  61/043,950
<151>  2008-04-10

<150>  61/084,814
<151>  2008-07-30

<160>  12    

<170>  PatentIn version 3.3

<210>  1
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Thr Thr His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asn Gly Arg Asn Lys Tyr Tyr Ala Asp Tyr Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Arg Asp Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Arg Gly Asp Gly Tyr Gly Asp Tyr Gly Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly His Gly Thr Leu Val Ser Val Ser Ser 
        115                 120             


<210>  2
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  2
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctaagactc     60

tcctgtgcag cctctggatt caggttcact acacacggca tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atatcatata atggaagaaa caaatactat    180

gcagactacg tgaacggccg attcaccatc tccagagacg attccaggga cacggtgttt    240

ctgcaaatga acagcctgag acctgaggac acggctatgt actactgtgc gaaagttagg    300

ggcgatggct acggtgacta tggctacttt gactactggg gccacggaac cctggtcagc    360

gtctcctca                                                            369


<210>  3
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Thr Thr His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asn Gly Arg Asn Lys Tyr Tyr Ala Asp Tyr Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Arg Asp Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Arg Gly Asp Gly Tyr Gly Asp Tyr Gly Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly His Gly Thr Leu Val Ser Val Ser Ser 
        115                 120             


<210>  4
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  4
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctaagactc     60

tcctgtgcag cctctggatt caggttcact acacacggca tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atatcatata atggaagaaa caaatactat    180

gcagactacg tgaacggccg attcaccatc tccagagacg attccaggga cacggtgttt    240

ctgcaaatga acagcctgag acctgaggac acggctatgt actactgtgc gaaagttagg    300

ggcgatggct acggtgacta tggctacttt gactactggg gccacggaac cctggtcagc    360

gtctcctca                                                            369


<210>  5
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Thr Thr His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asn Gly Arg Asn Lys Tyr Tyr Ala Asp Tyr Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Arg Asp Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Arg Gly Asp Gly Tyr Gly Asp Tyr Gly Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly His Gly Thr Leu Val Ser Val Ser Ser 
        115                 120             


<210>  6
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  6
gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc cgggcgggtc cctgagactc     60

tcctgtgcag cctctggatt caggttcact acacacggca tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atatcatata atggaagaaa caaatactat    180

gcagactacg tgaacggccg attcaccatc tccagagacg attccaggga cacggtgttt    240

ctgcaaatga acagcctgag acctgaggac acggctatgt actactgtgc gaaagttagg    300

ggcgatggct acggtgacta tggctacttt gactactggg gccacggaac cctggtcagc    360

gtctcctca                                                            369


<210>  7
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Thr Thr His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asn Gly Arg Asn Lys Tyr Tyr Ala Asp Tyr Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Arg Asp Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Arg Gly Asp Gly Tyr Gly Asp Tyr Gly Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly His Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  8
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  8
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctaagactc     60

tcctgtgcag cctctggatt caggttcact acacacggca tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atatcatata atggaagaaa caaatactat    180

gcagactacg tgaacggccg attcaccatc tccagagacg attccaggga cacggtgttt    240

ctgcaaatga acagcctgag acctgaggac acggctatgt actactgtgc gaaagttagg    300

ggcgatggct acggtgacta tggctacttt gactactggg gccacggaac cctggtcacc    360

gtctcctca                                                            369


<210>  9
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Tyr Asn Tyr Val Ser Trp Tyr 
            20                  25                  30          


Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Phe Asp Val Ser 
        35                  40                  45              


Arg Arg Ser Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
    50                  55                  60                  


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala 
65                  70                  75                  80  


Asp Tyr Tyr Cys Cys Ser Tyr Gly Gly Thr Tyr Leu Tyr Val Phe Gly 
                85                  90                  95      


Thr Gly Thr Thr Val Thr Val Leu Gly Gln 
            100                 105     


<210>  10
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  10
cagtctgccc tgactcagcc tcgctcagtg tccgggtctc ctggacagtc agtcaccatc     60

tcctgcactg gaacttataa ctatgtctcc tggtaccaac agcacccagg caaagccccc    120

aaactcatga tttttgatgt cagtaggcgg tcctcagggg tccctgatcg cttctctggc    180

tccaagtctg gcaacacggc ctccctgacc atctctgggc tccaggctga ggatgaggct    240

gattattact gctgctcata tggaggcacc tacctttatg tcttcggaac tgggactacg    300

gtcaccgtcc ttggtcag                                                  318


<210>  11
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Asp Ser Gly Ser Tyr Gly Gln Ser Gly Gly Glu Gln Gln Ser 
1               5                   10                  15      


Tyr Ser Thr Tyr Gly Asn Pro Gly Ser Gln Gly Tyr Gly Gln Ala Ser 
            20                  25                  30          


Gln Ser Tyr Ser Gly Tyr Gly Gln Thr Thr Asp Ser Ser Tyr Gly Gln 
        35                  40                  45              


Asn Tyr Ser Gly Tyr Ser Ser Tyr Gly Gln Ser Gln Ser Gly Tyr Ser 
    50                  55                  60                  


Gln Ser Tyr Gly Gly Tyr Glu Asn Gln Lys Gln Ser Ser Tyr Ser Gln 
65                  70                  75                  80  


Gln Pro Tyr Asn Asn Gln Gly Gln Gln Gln Asn Met Glu Ser Ser Gly 
                85                  90                  95      


Ser Gln Gly Gly Arg Ala Pro Ser Tyr Asp Gln Pro Asp Tyr Gly Gln 
            100                 105                 110         


Gln Asp Ser Tyr Asp Gln Gln Ser Gly Tyr Asp Gln His Gln Gly Ser 
        115                 120                 125             


Tyr Asp Glu Gln Ser Asn Tyr Asp Gln Gln His Asp Ser Tyr Ser Gln 
    130                 135                 140                 


Asn Gln Gln Ser Tyr His Ser Gln Arg Glu Asn Tyr Ser His His Thr 
145                 150                 155                 160 


Gln Asp Asp Arg Arg Asp Val Ser Arg Tyr Gly Glu Asp Asn Arg Gly 
                165                 170                 175     


Tyr Gly Gly Ser Gln Gly Gly Gly Arg Gly Arg Gly Gly Tyr Asp Lys 
            180                 185                 190         


Asp Gly Arg Gly Pro Met Thr Gly Ser Ser Gly Gly Asp Arg Gly Gly 
        195                 200                 205             


Phe Lys Asn Phe Gly Gly His Arg Asp Tyr Gly Pro Arg Thr Asp Ala 
    210                 215                 220                 


Asp Ser Glu Ser Asp Asn Ser Asp Asn Asn Thr Ile Phe Val Gln Gly 
225                 230                 235                 240 


Leu Gly Glu Gly Val Ser Thr Asp Gln Val Gly Glu Phe Phe Lys Gln 
                245                 250                 255     


Ile Gly Ile Ile Lys Thr Asn Lys Lys Thr Gly Lys Pro Met Ile Asn 
            260                 265                 270         


Leu Tyr Thr Asp Lys Asp Thr Gly Lys Pro Lys Gly Glu Ala Thr Val 
        275                 280                 285             


Ser Phe Asp Asp Pro Pro Ser Ala Lys Ala Ala Ile Asp Trp Phe Asp 
    290                 295                 300                 


Gly Lys Glu Phe His Gly Asn Ile Ile Lys Val Ser Phe Ala Thr Arg 
305                 310                 315                 320 


Arg Pro Glu Phe Met Arg Gly Gly Gly Ser Gly Gly Gly Arg Arg Gly 
                325                 330                 335     


Arg Gly Gly Tyr Arg Gly Arg Gly Gly Phe Gln Gly Arg Gly Gly Asp 
            340                 345                 350         


Pro Lys Ser Gly Asp Trp Val Cys Pro Asn Pro Ser Cys Gly Asn Met 
        355                 360                 365             


Asn Phe Ala Arg Arg Asn Ser Cys Asn Gln Cys Asn Glu Pro Arg Pro 
    370                 375                 380                 


Glu Asp Ser Arg Pro Ser Gly Gly Asp Phe Arg Gly Arg Gly Tyr Gly 
385                 390                 395                 400 


Gly Glu Arg Gly Tyr Arg Gly Arg Gly Gly Arg Gly Gly Asp Arg Gly 
                405                 410                 415     


Gly Tyr Gly Gly Asp Arg Ser Gly Gly Gly Tyr Gly Gly Asp Arg Ser 
            420                 425                 430         


Ser Gly Gly Gly Tyr Ser Gly Asp Arg Ser Gly Gly Gly Tyr Gly Gly 
        435                 440                 445             


Asp Arg Ser Gly Gly Gly Tyr Gly Gly Asp Arg Gly Gly Gly Tyr Gly 
    450                 455                 460                 


Gly Asp Arg Gly Gly Gly Tyr Gly Gly Asp Arg Gly Gly Gly Tyr Gly 
465                 470                 475                 480 


Gly Asp Arg Gly Gly Tyr Gly Gly Asp Arg Gly Gly Gly Tyr Gly Gly 
                485                 490                 495     


Asp Arg Gly Gly Tyr Gly Gly Asp Arg Gly Gly Tyr Gly Gly Asp Arg 
            500                 505                 510         


Gly Gly Tyr Gly Gly Asp Arg Gly Gly Tyr Gly Gly Asp Arg Ser Arg 
        515                 520                 525             


Gly Gly Tyr Gly Gly Asp Arg Gly Gly Gly Ser Gly Tyr Gly Gly Asp 
    530                 535                 540                 


Arg Ser Gly Gly Tyr Gly Gly Asp Arg Ser Gly Gly Gly Tyr Gly Gly 
545                 550                 555                 560 


Asp Arg Gly Gly Gly Tyr Gly Gly Asp Arg Gly Gly Tyr Gly Gly Lys 
                565                 570                 575     


Met Gly Gly Arg Asn Asp Tyr Arg Asn Asp Gln Arg Asn Arg Pro Tyr 
            580                 585                 590         


<210>  12
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Asp Ser Gly Ser Tyr Gly Gln Ser Gly Gly Glu Gln Gln Ser 
1               5                   10                  15      


Tyr Ser Thr Tyr Gly Asn Pro Gly Ser Gln Gly Tyr Gly Gln Ala Ser 
            20                  25                  30          


Gln Ser Tyr Ser Gly Tyr Gly Gln Thr Thr Asp Ser Ser Tyr Gly Gln 
        35                  40                  45              


Asn Tyr Ser Gly Tyr Ser Ser Tyr Gly Gln Ser Tyr Ser Gln Ser Tyr 
    50                  55                  60                  


Gly Gly Tyr Glu Asn Gln Lys Gln Ser Ser Tyr Ser Gln Gln Pro Tyr 
65                  70                  75                  80  


Asn Asn Gln Gly Gln Gln Gln Asn Met Glu Ser Ser Gly Ser Gln Gly 
                85                  90                  95      


Gly Arg Ala Pro Ser Tyr Asp Gln Pro Asp Tyr Gly Gln Gln Asp Ser 
            100                 105                 110         


Tyr Asp Gln Gln Ser Gly Tyr Asp Gln His Gln Gly Ser Tyr Asp Glu 
        115                 120                 125             


Gln Ser Asn Tyr Asp Gln Gln His Asp Ser Tyr Ser Gln Asn Gln Gln 
    130                 135                 140                 


Ser Tyr His Ser Gln Arg Glu Asn Tyr Ser His His Thr Gln Asp Asp 
145                 150                 155                 160 


Arg Arg Asp Val Ser Arg Tyr Gly Glu Asp Asn Arg Gly Tyr Gly Gly 
                165                 170                 175     


Ser Gln Gly Gly Gly Arg Gly Arg Gly Gly Tyr Asp Lys Asp Gly Arg 
            180                 185                 190         


Gly Pro Met Thr Gly Ser Ser Gly Gly Asp Arg Gly Gly Phe Lys Asn 
        195                 200                 205             


Phe Gly Gly His Arg Asp Tyr Gly Pro Arg Thr Asp Ala Asp Ser Glu 
    210                 215                 220                 


Ser Asp Asn Ser Asp Asn Asn Thr Ile Phe Val Gln Gly Leu Gly Glu 
225                 230                 235                 240 


Gly Val Ser Thr Asp Gln Val Gly Glu Phe Phe Lys Gln Ile Gly Ile 
                245                 250                 255     


Ile Lys Thr Asn Lys Lys Thr Gly Lys Pro Met Ile Asn Leu Tyr Thr 
            260                 265                 270         


Asp Lys Asp Thr Gly Lys Pro Lys Gly Glu Ala Thr Val Ser Phe Asp 
        275                 280                 285             


Asp Pro Pro Ser Ala Lys Ala Ala Ile Asp Trp Phe Asp Gly Lys Glu 
    290                 295                 300                 


Phe His Gly Asn Ile Ile Lys Val Ser Phe Ala Thr Arg Arg Pro Glu 
305                 310                 315                 320 


Phe Met Arg Gly Gly Gly Ser Gly Gly Gly Arg Arg Gly Arg Gly Gly 
                325                 330                 335     


Tyr Arg Gly Arg Gly Gly Phe Gln Gly Arg Gly Gly Asp Pro Lys Ser 
            340                 345                 350         


Gly Asp Trp Val Cys Pro Asn Pro Ser Cys Gly Asn Met Asn Phe Ala 
        355                 360                 365             


Arg Arg Asn Ser Cys Asn Gln Cys Asn Glu Pro Arg Pro Glu Asp Ser 
    370                 375                 380                 


Arg Pro Ser Gly Gly Asp Phe Arg Gly Arg Gly Tyr Gly Gly Glu Arg 
385                 390                 395                 400 


Gly Tyr Arg Gly Arg Gly Gly Arg Gly Gly Asp Arg Gly Gly Tyr Gly 
                405                 410                 415     


Gly Asp Arg Ser Gly Gly Gly Tyr Gly Gly Asp Arg Ser Ser Gly Gly 
            420                 425                 430         


Gly Tyr Ser Gly Asp Arg Ser Gly Gly Gly Tyr Gly Gly Asp Arg Ser 
        435                 440                 445             


Gly Gly Gly Tyr Gly Gly Asp Arg Gly Gly Gly Tyr Gly Gly Asp Arg 
    450                 455                 460                 


Gly Gly Gly Tyr Gly Gly Asp Arg Gly Gly Gly Tyr Gly Gly Asp Arg 
465                 470                 475                 480 


Gly Gly Tyr Gly Gly Asp Arg Gly Gly Gly Tyr Gly Gly Asp Arg Gly 
                485                 490                 495     


Gly Tyr Gly Gly Asp Arg Gly Gly Tyr Gly Gly Asp Arg Gly Gly Tyr 
            500                 505                 510         


Gly Gly Asp Arg Gly Gly Tyr Gly Gly Asp Arg Ser Arg Gly Gly Tyr 
        515                 520                 525             


Gly Gly Asp Arg Gly Gly Gly Ser Gly Tyr Gly Gly Asp Arg Ser Gly 
    530                 535                 540                 


Gly Tyr Gly Gly Asp Arg Ser Gly Gly Gly Tyr Gly Gly Asp Arg Gly 
545                 550                 555                 560 


Gly Gly Tyr Gly Gly Asp Arg Gly Gly Tyr Gly Gly Lys Met Gly Gly 
                565                 570                 575     


Arg Asn Asp Tyr Arg Asn Asp Gln Arg Asn Arg Pro Tyr 
            580                 585                 


