                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Muzykantov, Vladimir R.
       Zaitsev, Sergei V.
       Ding, Bi-Sen
       Cines, Douglas B.
 
<120>  TARGETING RECOMBINANT THERAPEUTICS TO CIRCULATING RED BLOOD CELLS

<130>  UPN-U4563APCT

<150>  US 61/018,636
<151>  2008-01-02

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  1

Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ala Ala Ala 
1               5                   10              


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  2

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  3

Met Tyr Pro Arg Gly Asn 
1               5       


<210>  4
<211>  253
<212>  PRT
<213>  Mus musculus

<400>  4

Arg Ser Pro Trp Pro Gly Val Pro Thr Ser Gln Val Lys Leu Gln Glu 
1               5                   10                  15      


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
            20                  25                  30          


Val Ala Ser Gly Phe Thr Phe Arg Asp His Trp Met Asn Trp Val Arg 
        35                  40                  45              


Gln Ala Pro Gly Lys Thr Met Glu Trp Ile Gly Asp Ile Arg Pro Asp 
    50                  55                  60                  


Gly Ser Asp Thr Asn Tyr Ala Pro Ser Val Arg Asn Arg Phe Thr Ile 
65                  70                  75                  80  


Ser Arg Asp Asn Ala Arg Ser Ile Leu Tyr Leu Gln Met Ser Asn Met 
                85                  90                  95      


Arg Ser Asp Tyr Thr Ala Thr Tyr Tyr Cys Val Arg Asp Ser Pro Thr 
            100                 105                 110         


Arg Ala Gly Leu Met Asp Ala Trp Gly Gln Gly Ala Ser Val Thr Val 
        115                 120                 125             


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Asp Ile Gln Met Ile Gln Ser Pro Ser Val Leu Ser Ala Ser Val 
145                 150                 155                 160 


Gly Asp Arg Val Thr Leu Asn Cys Lys Ala Ser Gln Asn Ile Asn Lys 
                165                 170                 175     


Tyr Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Val Leu 
            180                 185                 190         


Ile Tyr Asn Thr Asn Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Pro Glu Asp Phe Ala Thr Tyr Phe Cys Phe Gln His Tyr Thr Trp Pro 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Ala 
                245                 250             


<210>  5
<211>  266
<212>  PRT
<213>  Mus musculus

<400>  5

Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg Ile Ile Gly 
1               5                   10                  15      


Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp Phe Ala Ala Ile Tyr 
            20                  25                  30          


Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val Cys Gly Gly Ser Leu 
        35                  40                  45              


Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His Cys Phe Ile Asp Tyr 
    50                  55                  60                  


Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly Arg Ser Arg Leu Asn 
65                  70                  75                  80  


Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val Glu Asn Leu Ile Leu 
                85                  90                  95      


His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His His Asn Asp Ile Ala 
            100                 105                 110         


Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys Ala Gln Pro Ser Arg 
        115                 120                 125             


Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr Asn Asp Pro Gln Phe 
    130                 135                 140                 


Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys Glu Asn Ser Thr Asp 
145                 150                 155                 160 


Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val Val Lys Leu Ile Ser 
                165                 170                 175     


His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly Ser Glu Val Thr Thr 
            180                 185                 190         


Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys Thr Asp Ser Cys Gln 
        195                 200                 205             


Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu Gln Gly Arg Met Thr 
    210                 215                 220                 


Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys Ala Leu Lys Asp Lys 
225                 230                 235                 240 


Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu Pro Trp Ile Arg Ser 
                245                 250                 255     


His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
            260                 265     


<210>  6
<211>  554
<212>  PRT
<213>  Mus musculus

<400>  6

Arg Arg Pro Trp Pro Gly Val Pro Thr Ser Gln Val Lys Leu Gln Glu 
1               5                   10                  15      


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
            20                  25                  30          


Val Ala Ser Gly Phe Thr Phe Arg Asp His Trp Met Asn Trp Val Arg 
        35                  40                  45              


Gln Ala Pro Gly Lys Thr Met Glu Trp Ile Gly Asp Ile Arg Pro Asp 
    50                  55                  60                  


Gly Ser Asp Thr Asn Tyr Ala Pro Ser Val Arg Asn Arg Phe Thr Ile 
65                  70                  75                  80  


Ser Arg Asp Asn Ala Arg Ser Ile Leu Tyr Leu Gln Met Ser Asn Met 
                85                  90                  95      


Arg Ser Asp Tyr Thr Ala Thr Tyr Tyr Cys Val Arg Asp Ser Pro Thr 
            100                 105                 110         


Arg Ala Gly Leu Met Asp Ala Trp Gly Gln Gly Ala Ser Val Thr Val 
        115                 120                 125             


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Asp Ile Gln Met Ile Gln Ser Pro Ser Val Leu Ser Ala Ser Val 
145                 150                 155                 160 


Gly Asp Arg Val Thr Leu Asn Cys Lys Ala Ser Gln Asn Ile Asn Lys 
                165                 170                 175     


Tyr Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Val Leu 
            180                 185                 190         


Ile Tyr Asn Thr Asn Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Pro Glu Asp Phe Ala Thr Tyr Phe Cys Phe Gln His Tyr Thr Trp Pro 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Ala Ser Ser Ser 
                245                 250                 255     


Ser Gly Ser Ser Ser Ser Gly Ala Ala Ala Leu Lys Phe Gln Cys Gly 
            260                 265                 270         


Gln Lys Thr Leu Arg Pro Arg Ile Ile Gly Gly Glu Phe Thr Thr Ile 
        275                 280                 285             


Glu Asn Gln Pro Trp Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly 
    290                 295                 300                 


Ser Val Thr Tyr Val Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val 
305                 310                 315                 320 


Ile Ser Ala Thr His Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr 
                325                 330                 335     


Ile Val Tyr Leu Gly Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu 
            340                 345                 350         


Met Lys Phe Glu Val Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala 
        355                 360                 365             


Asp Thr Leu Ala His His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser 
    370                 375                 380                 


Lys Glu Gly Arg Cys Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys 
385                 390                 395                 400 


Leu Pro Ser Met Tyr Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile 
                405                 410                 415     


Thr Gly Phe Gly Lys Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln 
            420                 425                 430         


Leu Lys Met Thr Val Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln 
        435                 440                 445             


Pro His Tyr Tyr Gly Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala 
    450                 455                 460                 


Asp Pro Gln Trp Lys Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
465                 470                 475                 480 


Leu Val Cys Ser Leu Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser 
                485                 490                 495     


Trp Gly Arg Gly Cys Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg 
            500                 505                 510         


Val Ser His Phe Leu Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn 
        515                 520                 525             


Gly Leu Ala Leu Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His 
    530                 535                 540                 


Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
545                 550                 


<210>  7
<211>  356
<212>  PRT
<213>  Mus musculus

<400>  7

Arg Ser Pro Lys Gly Lys Ser Glu Asp Cys Tyr Val Gly Lys Gly Val 
1               5                   10                  15      


Thr Tyr Arg Gly Thr His Ser Leu Thr Thr Ser Gln Ala Ser Cys Leu 
            20                  25                  30          


Pro Trp Asn Ser Ile Val Leu Met Gly Lys Ser Tyr Thr Ala Trp Arg 
        35                  40                  45              


Thr Asn Ser Gln Ala Leu Gly Leu Gly Arg His Asn Tyr Cys Arg Asn 
    50                  55                  60                  


Pro Asp Gly Asp Ala Arg Pro Trp Cys His Val Met Lys Asp Arg Lys 
65                  70                  75                  80  


Leu Thr Trp Glu Tyr Cys Asp Met Ser Pro Cys Ser Thr Cys Gly Leu 
                85                  90                  95      


Arg Gln Tyr Lys Arg Pro Gln Phe Arg Ile Lys Gly Gly Leu Tyr Thr 
            100                 105                 110         


Asp Ile Thr Ser His Pro Trp Gln Ala Pro Ile Phe Val Ala Ala Ala 
        115                 120                 125             


Ala Ser Pro Gly Glu Arg Phe Leu Cys Gly Gly Val Leu Ile Ser Ser 
    130                 135                 140                 


Cys Trp Val Leu Ser Ala Ala His Cys Phe Leu Glu Arg Phe Pro Pro 
145                 150                 155                 160 


Asn His Leu Lys Val Val Leu Gly Arg Thr Tyr Arg Val Val Pro Gly 
                165                 170                 175     


Glu Glu Glu Gln Thr Phe Glu Ile Glu Lys Tyr Ile Val His Glu Glu 
            180                 185                 190         


Phe Asp Asp Asp Thr Tyr Asp Asn Asp Ile Ala Leu Leu Gln Leu Arg 
        195                 200                 205             


Ser Gln Ser Lys Gln Cys Ala Gln Glu Ser Ser Ser Val Gly Thr Ala 
    210                 215                 220                 


Cys Leu Pro Asp Pro Asn Leu Gln Leu Pro Asp Trp Thr Glu Cys Glu 
225                 230                 235                 240 


Leu Ser Gly Tyr Gly Lys His Glu Ala Ser Ser Pro Phe Phe Ser Asp 
                245                 250                 255     


Arg Leu Lys Glu Ala His Val Arg Leu Tyr Pro Ser Ser Arg Cys Thr 
            260                 265                 270         


Ser Gln His Leu Phe Asn Lys Thr Val Thr Asn Asn Met Leu Cys Ala 
        275                 280                 285             


Gly Asp Thr Arg Ser Gly Gly Asn Gln Asp Leu His Asp Ala Cys Gln 
    290                 295                 300                 


Gly Asp Ser Gly Gly Pro Leu Val Cys Met Ile Asn Lys Gln Met Thr 
305                 310                 315                 320 


Leu Thr Gly Ile Ile Ser Trp Gly Leu Gly Cys Gly Gln Lys Asp Val 
                325                 330                 335     


Pro Gly Val Tyr Thr Lys Val Thr Asn Tyr Leu Asp Trp Ile His Asp 
            340                 345                 350         


Asn Met Lys Gln 
        355     


<210>  8
<211>  620
<212>  PRT
<213>  Mus musculus

<400>  8

Arg Ser Pro Trp Pro Gly Val Pro Thr Ser Gln Val Lys Leu Gln Glu 
1               5                   10                  15      


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
            20                  25                  30          


Val Ala Ser Gly Phe Thr Phe Arg Asp His Trp Met Asn Trp Val Arg 
        35                  40                  45              


Gln Ala Pro Gly Lys Thr Met Glu Trp Ile Gly Asp Ile Arg Pro Asp 
    50                  55                  60                  


Gly Ser Asp Thr Asn Tyr Ala Pro Ser Val Arg Asn Arg Phe Thr Ile 
65                  70                  75                  80  


Ser Arg Asp Asn Ala Arg Ser Ile Leu Tyr Leu Gln Met Ser Asn Met 
                85                  90                  95      


Arg Ser Asp Tyr Thr Ala Thr Tyr Tyr Cys Val Arg Asp Ser Pro Thr 
            100                 105                 110         


Arg Ala Gly Leu Met Asp Ala Trp Gly Gln Gly Ala Ser Val Thr Val 
        115                 120                 125             


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Asp Ile Gln Met Ile Gln Ser Pro Ser Val Leu Ser Ala Ser Val 
145                 150                 155                 160 


Gly Asp Arg Val Thr Leu Asn Cys Lys Ala Ser Gln Asn Ile Asn Lys 
                165                 170                 175     


Tyr Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Val Leu 
            180                 185                 190         


Ile Tyr Asn Thr Asn Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Pro Glu Asp Phe Ala Thr Tyr Phe Cys Phe Gln His Tyr Thr Trp Pro 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Ala Ser Ser Ser 
                245                 250                 255     


Ser Gly Ser Ser Ser Ser Gly Ala Ala Ala Pro Lys Gly Lys Ser Glu 
            260                 265                 270         


Asp Cys Tyr Val Gly Lys Gly Val Thr Tyr Arg Gly Thr His Ser Leu 
        275                 280                 285             


Thr Thr Ser Gln Ala Ser Cys Leu Pro Trp Asn Ser Ile Val Leu Met 
    290                 295                 300                 


Gly Lys Ser Tyr Thr Ala Trp Arg Thr Asn Ser Gln Ala Leu Gly Leu 
305                 310                 315                 320 


Gly Arg His Asn Tyr Cys Arg Asn Pro Asp Gly Asp Ala Arg Pro Trp 
                325                 330                 335     


Cys His Val Met Lys Asp Arg Lys Leu Thr Trp Glu Tyr Cys Asp Met 
            340                 345                 350         


Ser Pro Cys Ser Thr Cys Gly Leu Arg Gln Tyr Lys Arg Pro Gln Phe 
        355                 360                 365             


Arg Ile Lys Gly Gly Leu Tyr Thr Asp Ile Thr Ser His Pro Trp Gln 
    370                 375                 380                 


Ala Pro Ile Phe Val Ala Ala Ala Ala Ser Pro Gly Glu Arg Phe Leu 
385                 390                 395                 400 


Cys Gly Gly Val Leu Ile Ser Ser Cys Trp Val Leu Ser Ala Ala His 
                405                 410                 415     


Cys Phe Leu Glu Arg Phe Pro Pro Asn His Leu Lys Val Val Leu Gly 
            420                 425                 430         


Arg Thr Tyr Arg Val Val Pro Gly Glu Glu Glu Gln Thr Phe Glu Ile 
        435                 440                 445             


Glu Lys Tyr Ile Val His Glu Glu Phe Asp Asp Asp Thr Tyr Asp Asn 
    450                 455                 460                 


Asp Ile Ala Leu Leu Gln Leu Arg Ser Gln Ser Lys Gln Cys Ala Gln 
465                 470                 475                 480 


Glu Ser Ser Ser Val Gly Thr Ala Cys Leu Pro Asp Pro Asn Leu Gln 
                485                 490                 495     


Leu Pro Asp Trp Thr Glu Cys Glu Leu Ser Gly Tyr Gly Lys His Glu 
            500                 505                 510         


Ala Ser Ser Pro Phe Phe Ser Asp Arg Leu Lys Glu Ala His Val Arg 
        515                 520                 525             


Leu Tyr Pro Ser Ser Arg Cys Thr Ser Gln His Leu Phe Asn Lys Thr 
    530                 535                 540                 


Val Thr Asn Asn Met Leu Cys Ala Gly Asp Thr Arg Ser Gly Gly Asn 
545                 550                 555                 560 


Gln Asp Leu His Asp Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
                565                 570                 575     


Cys Met Ile Asn Lys Gln Met Thr Leu Thr Gly Ile Ile Ser Trp Gly 
            580                 585                 590         


Leu Gly Cys Gly Gln Lys Asp Val Pro Gly Val Tyr Thr Lys Val Thr 
        595                 600                 605             


Asn Tyr Leu Asp Trp Ile His Asp Asn Met Lys Gln 
    610                 615                 620 


<210>  9
<211>  501
<212>  PRT
<213>  Mus musculus

<400>  9

Leu Ser Ala Leu Ala Lys Leu Gln Pro Thr Gly Ser Gln Cys Val Glu 
1               5                   10                  15      


His Glu Cys Phe Ala Leu Phe Gln Gly Pro Ala Thr Phe Leu Asp Ala 
            20                  25                  30          


Ser Gln Ala Cys Gln Arg Leu Gln Gly His Leu Met Thr Val Arg Ser 
        35                  40                  45              


Ser Val Ala Ala Asp Val Ile Ser Leu Leu Leu Ser Gln Ser Ser Met 
    50                  55                  60                  


Asp Leu Gly Pro Trp Ile Gly Leu Gln Leu Pro Gln Gly Cys Asp Asp 
65                  70                  75                  80  


Pro Val His Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr Gly Asp 
                85                  90                  95      


Asn His Thr Ser Tyr Ser Arg Trp Ala Arg Pro Asn Asp Gln Thr Ala 
            100                 105                 110         


Pro Leu Cys Gly Pro Leu Cys Val Thr Val Ser Thr Ala Thr Glu Ala 
        115                 120                 125             


Ala Pro Gly Glu Pro Ala Trp Glu Glu Lys Pro Cys Glu Thr Glu Thr 
    130                 135                 140                 


Gln Gly Phe Leu Cys Glu Phe Tyr Phe Thr Ala Ser Cys Arg Pro Leu 
145                 150                 155                 160 


Thr Val Asn Thr Arg Asp Pro Glu Ala Ala His Ile Ser Ser Thr Tyr 
                165                 170                 175     


Asn Thr Pro Phe Gly Val Ser Gly Ala Asp Phe Gln Thr Leu Pro Val 
            180                 185                 190         


Gly Ser Ser Ala Ala Val Glu Pro Leu Gly Leu Glu Leu Val Cys Arg 
        195                 200                 205             


Ala Pro Pro Gly Thr Ser Glu Gly His Trp Ala Trp Glu Ala Thr Gly 
    210                 215                 220                 


Ala Trp Asn Cys Ser Val Glu Asn Gly Gly Cys Glu Tyr Leu Cys Asn 
225                 230                 235                 240 


Arg Ser Thr Asn Glu Pro Arg Cys Leu Cys Pro Arg Asp Met Asp Leu 
                245                 250                 255     


Gln Ala Asp Gly Arg Ser Cys Ala Arg Pro Val Val Gln Ser Cys Asn 
            260                 265                 270         


Glu Leu Cys Glu His Phe Cys Val Ser Asn Ala Glu Val Pro Gly Ser 
        275                 280                 285             


Tyr Ser Cys Met Cys Glu Thr Gly Tyr Gln Leu Ala Ala Asp Gly His 
    290                 295                 300                 


Arg Cys Glu Asp Val Asp Asp Cys Lys Gln Gly Pro Asn Pro Cys Pro 
305                 310                 315                 320 


Gln Leu Cys Val Asn Thr Lys Gly Gly Phe Glu Cys Phe Cys Tyr Asp 
                325                 330                 335     


Gly Tyr Glu Leu Val Asp Gly Glu Cys Val Glu Leu Leu Asp Pro Cys 
            340                 345                 350         


Phe Gly Ser Asn Cys Glu Phe Gln Cys Gln Pro Val Ser Pro Thr Asp 
        355                 360                 365             


Tyr Arg Cys Ile Cys Ala Pro Gly Phe Ala Pro Lys Pro Asp Glu Pro 
    370                 375                 380                 


His Lys Cys Glu Met Phe Cys Asn Glu Thr Ser Cys Pro Ala Asp Cys 
385                 390                 395                 400 


Asp Pro Asn Ser Pro Thr Val Cys Glu Cys Pro Glu Gly Phe Ile Leu 
                405                 410                 415     


Asp Glu Gly Ser Val Cys Thr Asp Ile Asp Glu Cys Ser Gln Gly Glu 
            420                 425                 430         


Cys Phe Thr Ser Glu Cys Arg Asn Phe Pro Gly Ser Tyr Glu Cys Ile 
        435                 440                 445             


Cys Gly Pro Asp Thr Ala Leu Ala Gly Gln Ile Ser Lys Asp Cys Asp 
    450                 455                 460                 


Pro Ile Pro Val Arg Glu Asp Thr Lys Glu Glu Glu Gly Ser Gly Glu 
465                 470                 475                 480 


Pro Pro Val Ser Pro Thr Pro Gly Ser Pro Thr Gly Pro Pro Ser Ala 
                485                 490                 495     


Arg Pro Val His Ser 
            500     


<210>  10
<211>  789
<212>  PRT
<213>  Mus musculus

<400>  10

Arg Ser Pro Trp Pro Gly Val Pro Thr Ser Gln Val Lys Leu Gln Glu 
1               5                   10                  15      


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
            20                  25                  30          


Val Ala Ser Gly Phe Thr Phe Arg Asp His Trp Met Asn Trp Val Arg 
        35                  40                  45              


Gln Ala Pro Gly Lys Thr Met Glu Trp Ile Gly Asp Ile Arg Pro Asp 
    50                  55                  60                  


Gly Ser Asp Thr Asn Tyr Ala Pro Ser Val Arg Asn Arg Phe Thr Ile 
65                  70                  75                  80  


Ser Arg Asp Asn Ala Arg Ser Ile Leu Tyr Leu Gln Met Ser Asn Met 
                85                  90                  95      


Arg Ser Asp Tyr Thr Ala Thr Tyr Tyr Cys Val Arg Asp Ser Pro Thr 
            100                 105                 110         


Arg Ala Gly Leu Met Asp Ala Trp Gly Gln Gly Ala Ser Val Thr Val 
        115                 120                 125             


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Asp Ile Gln Met Ile Gln Ser Pro Ser Val Leu Ser Ala Ser Val 
145                 150                 155                 160 


Gly Asp Arg Val Thr Leu Asn Cys Lys Ala Ser Gln Asn Ile Asn Lys 
                165                 170                 175     


Tyr Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Val Leu 
            180                 185                 190         


Ile Tyr Asn Thr Asn Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Pro Glu Asp Phe Ala Thr Tyr Phe Cys Phe Gln His Tyr Thr Trp Pro 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Ala Ser Ser Ser 
                245                 250                 255     


Ser Gly Ser Ser Ser Ser Gly Ala Ala Ala Leu Ser Ala Leu Ala Lys 
            260                 265                 270         


Leu Gln Pro Thr Gly Ser Gln Cys Val Glu His Glu Cys Phe Ala Leu 
        275                 280                 285             


Phe Gln Gly Pro Ala Thr Phe Leu Asp Ala Ser Gln Ala Cys Gln Arg 
    290                 295                 300                 


Leu Gln Gly His Leu Met Thr Val Arg Ser Ser Val Ala Ala Asp Val 
305                 310                 315                 320 


Ile Ser Leu Leu Leu Ser Gln Ser Ser Met Asp Leu Gly Pro Trp Ile 
                325                 330                 335     


Gly Leu Gln Leu Pro Gln Gly Cys Asp Asp Pro Val His Leu Gly Pro 
            340                 345                 350         


Leu Arg Gly Phe Gln Trp Val Thr Gly Asp Asn His Thr Ser Tyr Ser 
        355                 360                 365             


Arg Trp Ala Arg Pro Asn Asp Gln Thr Ala Pro Leu Cys Gly Pro Leu 
    370                 375                 380                 


Cys Val Thr Val Ser Thr Ala Thr Glu Ala Ala Pro Gly Glu Pro Ala 
385                 390                 395                 400 


Trp Glu Glu Lys Pro Cys Glu Thr Glu Thr Gln Gly Phe Leu Cys Glu 
                405                 410                 415     


Phe Tyr Phe Thr Ala Ser Cys Arg Pro Leu Thr Val Asn Thr Arg Asp 
            420                 425                 430         


Pro Glu Ala Ala His Ile Ser Ser Thr Tyr Asn Thr Pro Phe Gly Val 
        435                 440                 445             


Ser Gly Ala Asp Phe Gln Thr Leu Pro Val Gly Ser Ser Ala Ala Val 
    450                 455                 460                 


Glu Pro Leu Gly Leu Glu Leu Val Cys Arg Ala Pro Pro Gly Thr Ser 
465                 470                 475                 480 


Glu Gly His Trp Ala Trp Glu Ala Thr Gly Ala Trp Asn Cys Ser Val 
                485                 490                 495     


Glu Asn Gly Gly Cys Glu Tyr Leu Cys Asn Arg Ser Thr Asn Glu Pro 
            500                 505                 510         


Arg Cys Leu Cys Pro Arg Asp Met Asp Leu Gln Ala Asp Gly Arg Ser 
        515                 520                 525             


Cys Ala Arg Pro Val Val Gln Ser Cys Asn Glu Leu Cys Glu His Phe 
    530                 535                 540                 


Cys Val Ser Asn Ala Glu Val Pro Gly Ser Tyr Ser Cys Met Cys Glu 
545                 550                 555                 560 


Thr Gly Tyr Gln Leu Ala Ala Asp Gly His Arg Cys Glu Asp Val Asp 
                565                 570                 575     


Asp Cys Lys Gln Gly Pro Asn Pro Cys Pro Gln Leu Cys Val Asn Thr 
            580                 585                 590         


Lys Gly Gly Phe Glu Cys Phe Cys Tyr Asp Gly Tyr Glu Leu Val Asp 
        595                 600                 605             


Gly Glu Cys Val Glu Leu Leu Asp Pro Cys Phe Gly Ser Asn Cys Glu 
    610                 615                 620                 


Phe Gln Cys Gln Pro Val Ser Pro Thr Asp Tyr Arg Cys Ile Cys Ala 
625                 630                 635                 640 


Pro Gly Phe Ala Pro Lys Pro Asp Glu Pro His Lys Cys Glu Met Phe 
                645                 650                 655     


Cys Asn Glu Thr Ser Cys Pro Ala Asp Cys Asp Pro Asn Ser Pro Thr 
            660                 665                 670         


Val Cys Glu Cys Pro Glu Gly Phe Ile Leu Asp Glu Gly Ser Val Cys 
        675                 680                 685             


Thr Asp Ile Asp Glu Cys Ser Gln Gly Glu Cys Phe Thr Ser Glu Cys 
    690                 695                 700                 


Arg Asn Phe Pro Gly Ser Tyr Glu Cys Ile Cys Gly Pro Asp Thr Ala 
705                 710                 715                 720 


Leu Ala Gly Gln Ile Ser Lys Asp Cys Asp Pro Ile Pro Val Arg Glu 
                725                 730                 735     


Asp Thr Lys Glu Glu Glu Gly Ser Gly Glu Pro Pro Val Ser Pro Thr 
            740                 745                 750         


Pro Gly Ser Pro Thr Gly Pro Pro Ser Ala Arg Pro Val His Ser Asp 
        755                 760                 765             


Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys 
    770                 775                 780                 


Asp Asp Asp Asp Lys 
785                 


