                         SEQUENCE LISTING

<110>  Elan Pharmaceuticals, Inc.
       Schenk, Dale  B.
       Wall, Jonathan
       Seubert, Peter A.
       Saldanha, Jose
 
<120>  Treatment and Prophylaxis of Amyloidosis

<130>  021452-0376734

<150>  61/007,544
<151>  2007-12-28

<150>  61/095,932
<151>  2008-09-10

<160>  177   

<170>  PatentIn version 3.4

<210>  1
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  2
<211>  76
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human amyloid protein A peptide

<400>  2

Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala Arg Asp 
1               5                   10                  15      


Met Tyr Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile Gly Ser 
            20                  25                  30          


Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys Arg Gly 
        35                  40                  45              


Pro Gly Gly Ala Tyr Ala Ala Glu Val Ile Ser Asp Ala Arg Glu Asn 
    50                  55                  60                  


Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser 
65                  70                  75      


<210>  3
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from amyloidosis peptide

<400>  3

Gly His Glu Asp Thr 
1               5   


<210>  4
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from amyloid A protein

<400>  4

Gly His Gly Ala Glu Asp Ser 
1               5           


<210>  5
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from amyloid A protein

<400>  5

Gly His Asp Ala Glu Asp Ser 
1               5           


<210>  6
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from amyloid protein

<400>  6

Gly His Gly Ala Glu Asp Ser 
1               5           


<210>  7
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from amyloid A protein

<400>  7

Gly Asp His Ala Glu Asp Ser 
1               5           


<210>  8
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from amyloid A protein

<400>  8

Ser Thr Val Ile Glu Asp Ser 
1               5           


<210>  9
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from amyloid A protein

<400>  9

Gly Arg Gly His Glu Asp Thr 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from amyloid A protein

<400>  10

Gly His Gly Ala Glu Asp Ser 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from amyloid A protein

<400>  11

Asn His Gly Leu Glu Thr Leu 
1               5           


<210>  12
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from amyloidosis peptide

<400>  12

His Glu Asp Thr 
1               


<210>  13
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  13

Ala Glu Asp Ser 
1               


<210>  14
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  14

Ala Glu Asp Thr 
1               


<210>  15
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  15

His Glu Asp Ala 
1               


<210>  16
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  AL V lambda fragment from amyloid protein

<400>  16

Thr Glu Asp Glu 
1               


<210>  17
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  AL V lambda fragment from amyloid protein

<400>  17

Phe Glu Asp Asp 
1               


<210>  18
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  AL V lambda fragment from amyloid protein


<220>
<221>  MISC_FEATURE
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  18

Ser Glu Asp Glu 
1               


<210>  19
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  AL V lambda fragment from amyloid protein


<220>
<221>  MISC_FEATURE
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  19

Ala Glu Asp Glu 
1               


<210>  20
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  AL V lambda fragment from amyloid protein

<400>  20

Pro Glu Asp Glu 
1               


<210>  21
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  AL V kappa fragment from amyloid protein


<220>
<221>  MISC_FEATURE
<223>  Consensue sequence derived from human amyloidogenic proteins

<400>  21

Pro Glu Asp Ile 
1               


<210>  22
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  AL V kappa fragment from amyloid protein


<220>
<221>  MISC_FEATURE
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  22

Pro Glu Asp Phe 
1               


<210>  23
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  AL V kappa fragment from amyloid protein


<220>
<221>  MISC_FEATURE
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  23

Ala Glu Asp Val 
1               


<210>  24
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  AL V kappa fragment from amyloid protein


<220>
<221>  MISC_FEATURE
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  24

Ser Glu Asp Phe 
1               


<210>  25
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  AL V kappa fragment from amyloid protein

<400>  25

Ser Glu Asp Ala 
1               


<210>  26
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  26

Pro Glu Asp Ser 
1               


<210>  27
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  27

Pro Glu Asp Leu 
1               


<210>  28
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  28

Thr Glu Asp Val 
1               


<210>  29
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  29

Ser Glu Asp Ile 
1               


<210>  30
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  30

Thr Glu Asp Thr 
1               


<210>  31
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  31

Leu Glu Asp Gly 
1               


<210>  32
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  32

Ala Glu Asp Met 
1               


<210>  33
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  33

His Glu Asp Ser 
1               


<210>  34
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  34

Cys Glu Asp Asp 
1               


<210>  35
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  35

Gln Glu Asp Ser 
1               


<210>  36
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  36

Arg Glu Asp Ser 
1               


<210>  37
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  37

Thr Glu Asp Gly 
1               


<210>  38
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  38

Gln Glu Asp Arg 
1               


<210>  39
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  39

Thr Glu Asp Leu 
1               


<210>  40
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  40

Pro Glu Asp Asn 
1               


<210>  41
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  41

Glu Glu Asp Pro 
1               


<210>  42
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  42

Leu Glu Asp Leu 
1               


<210>  43
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  43

Lys Glu Asp Ala 
1               


<210>  44
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  44

Ser Glu Asp Cys 
1               


<210>  45
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  45

Glu Glu Asp Asp 
1               


<210>  46
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  46

Ser Glu Asp Lys 
1               


<210>  47
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  47

Asp Glu Asp Asp 
1               


<210>  48
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  48

Asp Glu Asp Gly 
1               


<210>  49
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  49

Leu Glu Asp Glu 
1               


<210>  50
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  50

Gly Glu Asp Ala 
1               


<210>  51
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  51

Val Glu Asp Phe 
1               


<210>  52
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  52

Tyr Glu Asp Glu 
1               


<210>  53
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  53

Ile Glu Asp Leu 
1               


<210>  54
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  54

Trp Glu Asp Tyr 
1               


<210>  55
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  55

Asp Glu Asp Trp 
1               


<210>  56
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  56

Ser Glu Asp Leu 
1               


<210>  57
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  57

Tyr Glu Asp Gln 
1               


<210>  58
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  58

Leu Glu Asp Trp 
1               


<210>  59
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  59

Tyr Glu Asp Arg 
1               


<210>  60
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  60

Pro Glu Asp Lys 
1               


<210>  61
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Non-amyloid portion of serum amyloid A protein

<400>  61

Gly His Glu Asp Thr Met Ala Asp Gln Glu 
1               5                   10  


<210>  62
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  62

Ala Glu Asp Ala 
1               


<210>  63
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  63

Gln Glu Asp Leu 
1               


<210>  64
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  64

Val Glu Asp Leu 
1               


<210>  65
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  65

Leu Glu Asp Ala 
1               


<210>  66
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  66

Ser Glu Asp Gly 
1               


<210>  67
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from Malaria CS


<220>
<221>  MISC_FEATURE
<223>  T3 epitope

<400>  67

Glu Lys Lys Ile Ala Lys Met Glu Lys Ala Ser Ser Val Phe Asn Val 
1               5                   10                  15      


<210>  68
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from Hepititis B surface antigen residues 19-28

<400>  68

Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile 
1               5                   10  


<210>  69
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from mycobacterium heat shock protein 65 residues 153-171

<400>  69

Asp Gln Ser Ile Gly Asp Leu Ile Ala Glu Ala Met Asp Lys Val Gly 
1               5                   10                  15      


Asn Glu Gly 
            


<210>  70
<211>  14
<212>  PRT
<213>  Bicille calmette-guerin

<400>  70

Gln Val His Phe Gln Pro Leu Pro Pro Ala Val Val Lys Leu 
1               5                   10                  


<210>  71
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from Tetanus toxoid residues 830-844

<400>  71

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
1               5                   10                  15  


<210>  72
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from Tetanus toxoid residues 947-967

<400>  72

Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
1               5                   10                  15      


Ala Ser His Leu Glu 
            20      


<210>  73
<211>  16
<212>  PRT
<213>  HIV


<220>
<221>  MISC_FEATURE
<223>  HIV gb120 T1

<400>  73

Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala 
1               5                   10                  15      


<210>  74
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Pan DR epitope


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  74

Ala Lys Xaa Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10              


<210>  75
<211>  36
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein derived from Tetanus toxoid residues 830-844 and 
       947-967

<400>  75

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Phe 
1               5                   10                  15      


Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 
            20                  25                  30          


Ser His Leu Glu 
        35      


<210>  76
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from ovalbumin residues 323-389

<400>  76

Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly 
1               5                   10                  15      


Arg 
    


<210>  77
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from hemagglutinin influenza A virus

<400>  77

Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr 
1               5                   10              


<210>  78
<211>  65
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein derived from hemagglutinin influenza A residues 
       307-319, Malaria CD: T3 epitope, tetanus toxoid residues 830-844 
       and 947-967

<400>  78

Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Glu Lys Lys 
1               5                   10                  15      


Ile Ala Lys Met Glu Lys Ala Ser Ser Val Phe Asn Val Gln Tyr Ile 
            20                  25                  30          


Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Phe Asn Asn Phe 
        35                  40                  45              


Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu 
    50                  55                  60                  


Glu 
65  


<210>  79
<211>  37
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein

<400>  79

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Cys 
1               5                   10                  15      


Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
            20                  25                  30          


Ala Ser His Leu Glu 
        35          


<210>  80
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from human amyloid A protein

<400>  80

Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala Arg 
1               5                   10                  15  


<210>  81
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from human amyloid A protein

<400>  81

Gln Gly Trp Leu Thr Phe Leu Lys Ala Ala Gly Gln Gly Ala Lys 
1               5                   10                  15  


<210>  82
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from mouse amyloid A protein

<400>  82

Glu Ser Trp Arg Ser Phe Phe Lys Glu Ala 
1               5                   10  


<210>  83
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>   Derived from mouse amyloid A protein

<400>  83

Gly Phe Phe Ser Phe Val His Glu Ala Phe Gln Gly Ala Gly Asp 
1               5                   10                  15  


<210>  84
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from mouse amyloid A protein

<400>  84

Glu Ala Gly Gln Gly Ser Arg Asp 
1               5               


<210>  85
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from mouse amyloid A protein

<400>  85

Trp Tyr Ser Phe Phe Arg Glu Ala Val Gln Gly Thr Trp Asp 
1               5                   10                  


<210>  86
<211>  99
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  MISC_FEATURE
<223>  Lambda 2 fragments from human amyloid deposits

<400>  86

Gly Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Arg Gln 
1               5                   10                  15      


Thr Val Ala Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Val Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ala Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Arg Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Ala Leu 
            


<210>  87
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from serum amyloid A protein

<400>  87

Cys Gly Gly His Glu Asp Thr 
1               5           


<210>  88
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from serum amyloid A protein

<400>  88

Cys Gly Gly Ala Glu Asp Ser 
1               5           


<210>  89
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from serum amyloid A protein

<400>  89

Gly His Glu Asp Thr Ile Ala Asp Gln Glu 
1               5                   10  


<210>  90
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from serum amyloid A protein

<400>  90

Cys Gly Gly Ala Glu Asp Thr 
1               5           


<210>  91
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from serum amyloid A protein

<400>  91

Cys Gly Gly His Ala Asp Thr 
1               5           


<210>  92
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from serum amyloid A protein

<400>  92

Cys Gly Gly His Glu Ala Thr 
1               5           


<210>  93
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from serum amyloid A protein

<400>  93

Cys Gly Gly His Glu Asp Ala 
1               5           


<210>  94
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from serum amyloid A protein

<400>  94

Cys Gly Gly His Glu Asp Thr Met 
1               5               


<210>  95
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from serum amyloid A protein

<400>  95

Cys Gly Gly His Glu Asp Thr Met Ala 
1               5                   


<210>  96
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from serum amyloid A protein

<400>  96

Cys Gly Gly His Glu Asp Thr Met Ala Asp 
1               5                   10  


<210>  97
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Derived from serum amyloid A protein

<400>  97

Cys Gly Gly His Glu Asp 
1               5       


<210>  98
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HSAA1

<400>  98

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Glu Ala Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  99
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HSAA2

<400>  99

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Ser Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asn Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Leu Thr Gly His Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Lys Trp Gly Arg Ser Gly Arg Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  100
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HSAA3

<400>  100

Met Lys Leu Ser Thr Gly Ile Ile Phe Cys Ser Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Ser Gln Gly Trp Leu Thr Phe Leu Lys Ala Ala Gly Gln Gly Ala 
            20                  25                  30          


Lys Asp Met Trp Arg Ala Tyr Ser Asp Met Lys Glu Ala Asn Tyr Lys 
        35                  40                  45              


Lys Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Val Gln 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Thr Glu Val Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Asn Val Gln Arg Leu Thr Gly Asp His Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Gly Gln Ala Thr Asn Lys Trp Gly Gln Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  101
<211>  130
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HSAA4

<400>  101

Met Arg Leu Phe Thr Gly Ile Val Phe Cys Ser Leu Val Met Gly Val 
1               5                   10                  15      


Thr Ser Glu Ser Trp Arg Ser Phe Phe Lys Glu Ala Leu Gln Gly Val 
            20                  25                  30          


Gly Asp Met Gly Arg Ala Tyr Trp Asp Ile Met Ile Ser Asn His Gln 
        35                  40                  45              


Asn Ser Asn Arg Tyr Leu Tyr Ala Arg Gly Asn Tyr Asp Ala Ala Gln 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Lys Leu Ile Ser Arg Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Gly Leu Ile Asp Tyr Tyr Leu Phe Gly Asn Ser Ser 
                85                  90                  95      


Thr Val Leu Glu Asp Ser Lys Ser Asn Glu Lys Ala Glu Glu Trp Gly 
            100                 105                 110         


Arg Ser Gly Lys Asp Pro Asp Arg Phe Arg Pro Asp Gly Leu Pro Lys 
        115                 120                 125             


Lys Tyr 
    130 


<210>  102
<211>  76
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HAA1

<400>  102

Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala Arg Asp 
1               5                   10                  15      


Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile Gly Ser 
            20                  25                  30          


Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys Arg Gly 
        35                  40                  45              


Pro Gly Gly Val Trp Ala Ala Glu Ala Ile Ser Asp Ala Arg Glu Asn 
    50                  55                  60                  


Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser 
65                  70                  75      


<210>  103
<211>  76
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HAA2

<400>  103

Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala Arg Asp 
1               5                   10                  15      


Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile Gly Ser 
            20                  25                  30          


Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys Arg Gly 
        35                  40                  45              


Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asn Ala Arg Glu Asn 
    50                  55                  60                  


Ile Gln Arg Leu Thr Gly His Gly Ala Glu Asp Ser 
65                  70                  75      


<210>  104
<211>  76
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HAA3

<400>  104

Gln Gly Trp Leu Thr Phe Leu Lys Ala Ala Gly Gln Gly Ala Lys Asp 
1               5                   10                  15      


Met Trp Arg Ala Tyr Ser Asp Met Lys Glu Ala Asn Tyr Lys Lys Ser 
            20                  25                  30          


Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Val Gln Arg Gly 
        35                  40                  45              


Pro Gly Gly Val Trp Ala Thr Glu Val Ile Ser Asp Ala Arg Glu Asn 
    50                  55                  60                  


Val Gln Arg Leu Thr Gly Asp His Ala Glu Asp Ser 
65                  70                  75      


<210>  105
<211>  84
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HAA4

<400>  105

Glu Ser Trp Arg Ser Phe Phe Lys Glu Ala Leu Gln Gly Val Gly Asp 
1               5                   10                  15      


Met Gly Arg Ala Tyr Trp Asp Ile Met Ile Ser Asn His Gln Asn Ser 
            20                  25                  30          


Asn Arg Tyr Leu Tyr Ala Arg Gly Asn Tyr Asp Ala Ala Gln Arg Gly 
        35                  40                  45              


Pro Gly Gly Val Trp Ala Ala Lys Leu Ile Ser Arg Ser Arg Val Tyr 
    50                  55                  60                  


Leu Gln Gly Leu Ile Asp Tyr Tyr Leu Phe Gly Asn Ser Ser Thr Val 
65                  70                  75                  80  


Ile Glu Asp Ser 
                


<210>  106
<211>  117
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  MSAA1

<400>  106

Met Lys Leu Leu Thr Ser Leu Val Phe Cys Ser Leu Leu Leu Gly Val 
1               5                   10                  15      


Cys His Gly Gly Phe Phe Ser Phe Val His Glu Ala Phe Gln Gly Ala 
            20                  25                  30          


Gly Asp Met Trp Arg Ala Tyr Thr Asp Met Lys Glu Ala Asn Trp Lys 
        35                  40                  45              


Asn Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Gln 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Glu Lys Ile Ser Asp Gly Arg 
65                  70                  75                  80  


Glu Ala Phe Gln Glu Phe Phe Gly Arg Ile Ala Asp Gln Glu Ala Asn 
                85                  90                  95      


Arg His Gly Arg Ser Gly Lys Asp Pro Asn Tyr Tyr Arg Pro Pro Gly 
            100                 105                 110         


Leu Pro Asp Lys Tyr 
        115         


<210>  107
<211>  122
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  MSAA2

<400>  107

Met Lys Leu Leu Thr Ser Leu Val Phe Cys Ser Leu Leu Leu Gly Val 
1               5                   10                  15      


Cys His Gly Gly Phe Phe Ser Phe Ile Gly Glu Ala Phe Gln Gly Ala 
            20                  25                  30          


Gly Asp Met Trp Arg Ala Tyr Thr Asp Met Lys Glu Ala Gly Trp Lys 
        35                  40                  45              


Asp Gly Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Gln 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Glu Lys Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Ser Phe Gln Glu Phe Phe Gly Arg Gly His Glu Asp Thr Met Ala 
                85                  90                  95      


Asp Gln Glu Ala Asn Arg His Gly Arg Ser Gly Lys Asp Pro Asn Tyr 
            100                 105                 110         


Tyr Arg Pro Pro Gly Leu Pro Ala Lys Tyr 
        115                 120         


<210>  108
<211>  122
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  MSAA3

<400>  108

Met Lys Pro Ser Ile Ala Ile Ile Leu Cys Ile Leu Ile Leu Gly Val 
1               5                   10                  15      


Asp Ser Gln Arg Trp Val Gln Phe Met Lys Glu Ala Gly Gln Gly Ser 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Lys Lys Ala Asn Trp Lys 
        35                  40                  45              


Asn Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Arg 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Lys Val Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Ala Val Gln Lys Phe Thr Gly His Gly Ala Glu Asp Ser Arg Ala 
                85                  90                  95      


Asp Gln Phe Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Lys Arg Tyr 
        115                 120         


<210>  109
<211>  130
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  MSAA4

<400>  109

Met Arg Leu Ala Thr Val Ile Val Leu Cys Ser Leu Phe Leu Gly Val 
1               5                   10                  15      


Ser Gly Asp Gly Trp Tyr Ser Phe Phe Arg Glu Ala Val Gln Gly Thr 
            20                  25                  30          


Trp Asp Leu Trp Arg Ala Tyr Arg Asp Asn Leu Glu Ala Asn Tyr Gln 
        35                  40                  45              


Asn Ala Asp Gln Tyr Phe Tyr Ala Arg Gly Asn Tyr Glu Ala Gln Gln 
    50                  55                  60                  


Arg Gly Ser Gly Gly Ile Trp Ala Ala Lys Ile Ile Ser Thr Ser Arg 
65                  70                  75                  80  


Lys Tyr Phe Gln Gly Leu Leu Asn Arg Tyr Tyr Phe Gly Ile Arg Asn 
                85                  90                  95      


His Gly Leu Glu Thr Leu Gln Ala Thr Gln Lys Ala Glu Glu Trp Gly 
            100                 105                 110         


Arg Ser Gly Lys Asn Pro Asn His Phe Arg Pro Glu Gly Leu Pro Glu 
        115                 120                 125             


Lys Phe 
    130 


<210>  110
<211>  85
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  MAA1

<400>  110

Gly Phe Phe Ser Phe Val His Glu Ala Phe Gln Gly Ala Gly Asp Met 
1               5                   10                  15      


Trp Arg Ala Tyr Thr Asp Met Lys Glu Ala Asn Trp Lys Asn Ser His 
            20                  25                  30          


Glu Asp Thr Ile Ala Asp Gln Glu Ala Asp Lys Tyr Phe His Ala Arg 
        35                  40                  45              


Gly Asn Tyr Asp Ala Ala Gln Arg Gly Pro Gly Gly Val Trp Ala Ala 
    50                  55                  60                  


Glu Lys Ile Ser Asp Gly Arg Glu Ala Phe Gln Glu Phe Phe Gly Arg 
65                  70                  75                  80  


Gly His Glu Asp Thr 
                85  


<210>  111
<211>  75
<212>  PRT
<213>  Mouse


<220>
<221>  MISC_FEATURE
<223>  MAA2

<400>  111

Gly Phe Phe Ser Phe Ile Gly Glu Ala Phe Gln Gly Ala Gly Asp Met 
1               5                   10                  15      


Trp Arg Ala Tyr Thr Asp Met Lys Glu Ala Gly Trp Lys Asp Gly Asp 
            20                  25                  30          


Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Gln Arg Gly Pro 
        35                  40                  45              


Gly Gly Val Trp Ala Ala Glu Lys Ile Ser Asp Ala Arg Glu Ser Phe 
    50                  55                  60                  


Gln Glu Phe Phe Gly Arg Gly His Glu Asp Thr 
65                  70                  75  


<210>  112
<211>  68
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  MAA3

<400>  112

Glu Ala Gly Gln Gly Ser Arg Asp Met Trp Arg Ala Tyr Ser Asp Met 
1               5                   10                  15      


Lys Lys Ala Asn Trp Lys Asn Ser Asp Lys Tyr Phe His Ala Arg Gly 
            20                  25                  30          


Asn Tyr Asp Ala Ala Arg Arg Gly Pro Gly Gly Ala Trp Ala Ala Lys 
        35                  40                  45              


Val Ile Ser Asp Ala Arg Glu Ala Val Gln Lys Phe Thr Gly His Gly 
    50                  55                  60                  


Ala Glu Asp Ser 
65              


<210>  113
<211>  82
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  MAA4

<400>  113

Trp Tyr Ser Phe Phe Arg Glu Ala Val Gln Gly Thr Trp Asp Leu Trp 
1               5                   10                  15      


Arg Ala Tyr Arg Asp Asn Leu Glu Ala Asn Tyr Gln Asn Ala Asp Gln 
            20                  25                  30          


Tyr Phe Tyr Ala Arg Gly Asn Tyr Glu Ala Gln Gln Arg Gly Ser Gly 
        35                  40                  45              


Gly Ile Trp Ala Ala Lys Ile Ile Ser Thr Ser Arg Lys Tyr Phe Gln 
    50                  55                  60                  


Gly Leu Leu Asn Arg Tyr Tyr Phe Gly Ile Arg Asn His Gly Leu Glu 
65                  70                  75                  80  


Thr Leu 
        


<210>  114
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HSAA1 alpha

<400>  114

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Glu Ala Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  115
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HSSA1 beta

<400>  115

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Phe Phe Gly His Asp Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  116
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HSSA1 gamma

<400>  116

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Glu Ala Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Phe Phe Gly His Asp Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Lys Trp Gly Arg Ser Gly Arg Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  117
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HSAA2 alpha

<400>  117

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Ser Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asn Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Leu Thr Gly His Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Lys Trp Gly Arg Ser Gly Arg Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  118
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HSAA2 beta

<400>  118

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Ser Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asn Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Leu Thr Gly Arg Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Lys Trp Gly Arg Ser Gly Arg Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  119
<211>  104
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HAA1 beta isoform

<400>  119

Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala Arg Asp 
1               5                   10                  15      


Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile Gly Ser 
            20                  25                  30          


Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys Arg Gly 
        35                  40                  45              


Pro Gly Gly Val Trp Ala Ala Glu Ala Ile Ser Asp Ala Arg Glu Asn 
    50                  55                  60                  


Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala Asp Gln 
65                  70                  75                  80  


Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His Phe Arg 
                85                  90                  95      


Pro Ala Gly Leu Pro Glu Lys Tyr 
            100                 


<210>  120
<211>  102
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Serum amyloid A protein

<400>  120

Gly Phe Phe Ser Phe Ile Gly Glu Ala Phe Gln Gly Ala Gly Asp Met 
1               5                   10                  15      


Trp Arg Ala Tyr Thr Asp Met Lys Glu Ala Gly Trp Lys Asp Gly Asp 
            20                  25                  30          


Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Gln Arg Gly Pro 
        35                  40                  45              


Gly Gly Val Trp Ala Ala Glu Lys Ile Ser Asp Ala Arg Glu Ser Gln 
    50                  55                  60                  


Glu Phe Phe Gly Arg Gly His Glu Asp Thr Met Ala Asp Gln Glu Ala 
65                  70                  75                  80  


Asn Arg His Gly Arg Ser Gly Lys Asp Pro Asn Tyr Tyr Arg Pro Pro 
                85                  90                  95      


Gly Leu Pro Ala Lys Tyr 
            100         


<210>  121
<211>  84
<212>  PRT
<213>  Canis lupus familiaris (Shar pei)


<220>
<221>  MISC_FEATURE
<223>  Serum amyloid A protein

<400>  121

Trp Tyr Ser Phe Val Gly Glu Ala Ala Gln Gly Ala Trp Asp Met Leu 
1               5                   10                  15      


Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Lys Asn Ser Asp Lys 
            20                  25                  30          


Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Gln Arg Gly Pro Gly 
        35                  40                  45              


Gly Ala Trp Ala Ala Lys Val Ile Ser Asp Ala Arg Glu Asn Ser Gln 
    50                  55                  60                  


Arg Asp Ser Gly His Gly Ala Glu Asp Ser Lys Ala Asp Gln Ala Ala 
65                  70                  75                  80  


Asn Glu Trp Gly 
                


<210>  122
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid insert between positions 67 and 68 of Shar Pei 
       sequence

<400>  122

Ile Thr Asp Leu Leu Arg Phe Gly 
1               5               


<210>  123
<211>  95
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  kpla

<220>
<221>  MISC_FEATURE
<223>  Germline sequences of V kappa light chain

<400>  123

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser 
                85                  90                  95  


<210>  124
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  kplb

<220>
<221>  MISC_FEATURE
<223>  Germline sequences of V kappa light chain

<400>  124

Ser Gln Asp Asn Tyr Asn Asp Asn Thr Asp Phe Glu Ile Asp Asn Leu 
1               5                   10                  15      


Pro 
    


<210>  125
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  kplc

<220>
<221>  MISC_FEATURE
<223>  Germline sequences of V kappa light chain

<400>  125

Ser Tyr Asn Ala Gln Asp Glu Ser Tyr Thr Pro 
1               5                   10      


<210>  126
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  kpld

<220>
<221>  MISC_FEATURE
<223>  Germline sequences of V kappa light chain

<400>  126

Ser Gly Arg Asn Asp Gly Arg Ala Gln Glu Leu His Pro 
1               5                   10              


<210>  127
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  kple

<220>
<221>  MISC_FEATURE
<223>  Germline sequences of V kappa light chain

<400>  127

Ser Gly Asn Tyr Phe Ser Ala Gln Asp Glu Pro 
1               5                   10      


<210>  128
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  kplf

<220>
<221>  MISC_FEATURE
<223>  Germline sequences of V kappa light chain

<400>  128

Ala Leu Ser Gly Ala Asp Asp Glu Phe Asn Pro 
1               5                   10      


<210>  129
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  kplg

<220>
<221>  MISC_FEATURE
<223>  Germline sequences of V kappa light chain

<400>  129

Ser Val Gly Ala Gln Asp Glu Ala Phe Pro 
1               5                   10  


<210>  130
<211>  51
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  kp2a

<220>
<221>  MISC_FEATURE
<223>  Germline sequences of V kappa light chain

<400>  130

Val Thr Leu Ser Pro Val Thr Pro Glu Pro Ala Ser Ser Ser Leu Leu 
1               5                   10                  15      


Asp Ser Asp Asp Gly Asn Thr Tyr Asp Leu Gln Ser Gln Thr Leu Tyr 
            20                  25                  30          


Arg Ala Asp Asp Lys Arg Val Glu Ala Glu Val Gly Val Met Arg Ile 
        35                  40                  45              


Glu Phe Pro 
    50      


<210>  131
<211>  49
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  kp2b

<220>
<221>  MISC_FEATURE
<223>  Germline sequences of V kappa light chain

<400>  131

Val Leu Ser Pro Val Thr Pro Glu Pro Ala Ser Ser Ser Leu Leu His 
1               5                   10                  15      


Ser Asn Gly Tyr Asn Tyr Asp Leu Gln Ser Gln Leu Gly Asn Arg Ala 
            20                  25                  30          


Asp Asp Lys Arg Val Glu Ala Glu Val Gly Val Met Ala Leu Gln Thr 
        35                  40                  45              


Pro 
    


<210>  132
<211>  50
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  kp2c

<220>
<221>  MISC_FEATURE
<223>  Germline sequences of V kappa light chain

<400>  132

Val Thr Leu Ser Val Thr Pro Gln Pro Ala Ser Ser Lys Ser Leu Leu 
1               5                   10                  15      


His Ser Asp Gly Lys Thr Tyr Tyr Leu Gln Pro Gln Glu Val Asn Arg 
            20                  25                  30          


Phe Asp Asp Lys Arg Val Glu Ala Glu Val Gly Val Met Ser Ile Gln 
        35                  40                  45              


Leu Pro 
    50  


<210>  133
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  kp3a

<220>
<221>  MISC_FEATURE
<223>  Germline sequences of V kappa light chain

<400>  133

Glu Val Ala Val Pro Glu Ala Leu Ser Val Asn Gln Arg Gly Thr Arg 
1               5                   10                  15      


Ala Thr Ile Ala Ser Glu Val Asn Trp Pro 
            20                  25      


<210>  134
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  kp3b

<220>
<221>  MISC_FEATURE
<223>  Germline sequences of V kappa light chain

<400>  134

Glu Val Leu Gly Leu Pro Glu Ala Leu Ser Val Ser Tyr Gln Arg Gly 
1               5                   10                  15      


Arg Ala Thr Ile Asp Asp Arg Glu Glu Val Gly Ser Pro 
            20                  25                  


<210>  135
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  kp3c

<220>
<221>  MISC_FEATURE
<223>  Germline sequences of V kappa light chain

<400>  135

Glu Val Leu Ala Leu Pro Glu Ala Leu Ser Val Ser Tyr Gln Arg Asp 
1               5                   10                  15      


Asn Arg Ala Thr Ile Ala Asp Glu Glu Val Arg Ser Asn Trp Pro 
            20                  25                  30      


<210>  136
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  kp4

<220>
<221>  MISC_FEATURE
<223>  Germline sequences of V lambda light chain

<400>  136

Val Asp Ser Ala Val Leu Glu Ala Asn Lys Ser Val Leu Tyr Ser Ser 
1               5                   10                  15      


Asn Asn Lys Asn Tyr Gln Pro Trp Thr Arg Asp Asp Ala Glu Val Val 
            20                  25                  30          


Tyr Thr Pro 
        35  


<210>  137
<211>  49
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  kp5

<220>
<221>  MISC_FEATURE
<223>  V lambda light chain

<400>  137

Glu Thr Thr Leu Ala Phe Met Thr Pro Lys Asn Ser Lys Asp Asp Asp 
1               5                   10                  15      


Asp Met Asn Glu Ala Ile Phe Ile Gln Glu Thr Thr Val Pro Ile Pro 
            20                  25                  30          


Tyr Asp Asn Asn Ile Glu Ser Glu Ala Tyr Phe Leu His Asp Asn Phe 
        35                  40                  45              


Pro 
    


<210>  138
<211>  97
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  lmla

<220>
<221>  MISC_FEATURE
<223>  V lambda light chain

<400>  138

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr 
65                  70                  75                  80  


Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu Ser 
                85                  90                  95      


Ala 
    


<210>  139
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  lmlb

<220>
<221>  MISC_FEATURE
<223>  V lambda light chain

<400>  139

Ala Gly Thr Arg Ser Tyr Arg Gln Val Ser Ala Ser Arg Ser Glu Ala 
1               5                   10                  15      


Ala Asp Gly 
            


<210>  140
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  lmlc

<220>
<221>  MISC_FEATURE
<223>  V lambda light chain

<400>  140

Val Gly Arg Thr Ala Gly Tyr Asp His Gly Ser Asn Val Ser Ala Ala 
1               5                   10                  15      


Glu Gln Ser Tyr Gly 
            20      


<210>  141
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  lm2a

<220>
<221>  MISC_FEATURE
<223>  V lambda light chain

<400>  141

Ala Ala Gly Ser Ser Ile Thr Thr Asp Val Ser Tyr Leu His Lys Met 
1               5                   10                  15      


Gly Ser Val Ser Ala Ala Glu Gln Ser Tyr Gly 
            20                  25          


<210>  142
<211>  34
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  lm2b

<220>
<221>  MISC_FEATURE
<223>  V lambda light chain

<400>  142

Ala Arg Gly Ser Val Ile Thr Thr Asp Val Gly Tyr His Lys Met Asp 
1               5                   10                  15      


Val Ser Val Asn Thr Ser Thr Ser Ala Glu Cys Ser Tyr Ala Gly Tyr 
            20                  25                  30          


Thr Phe 
        


<210>  143
<211>  41
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  lm3a

<220>
<221>  MISC_FEATURE
<223>  V lambda light chain

<400>  143

Ser Tyr Val Lys Thr Ala Arg Thr Gly Asn Asn Ile Gly Ser Lys Ser 
1               5                   10                  15      


His Lys Gln Val Val Val Asp Asp Ser Asp Glu Asn Asn Thr Thr Ser 
            20                  25                  30          


Arg Val Glu Ala Gln Val Ser Asp His 
        35                  40      


<210>  144
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  lm3b

<220>
<221>  MISC_FEATURE
<223>  V lambda light chain

<400>  144

Ser Tyr Glu Val Ser Thr Ala Arg Thr Asp Ala Leu Pro Lys Gln Ala 
1               5                   10                  15      


Tyr Lys Gln Val Val Lys Asp Ser Glu Glu Ser Thr Val Thr Ser Val 
            20                  25                  30          


Ala Glu Gln Ser Ala Gly 
        35              


<210>  145
<211>  39
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  lm3c

<220>
<221>  MISC_FEATURE
<223>  V lambda light chain

<400>  145

Ser Tyr Glu Val Ser Thr Ala Ser Thr Asp Lys Leu Gly Asp Lys Ala 
1               5                   10                  15      


Cys Lys Gln Ser Val Val Gln Asp Ser Glu Asn Asn Thr Thr Ser Thr 
            20                  25                  30          


Ala Met Gln Ala Thr Ala His 
        35                  


<210>  146
<211>  23
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  lm4

<220>
<221>  MISC_FEATURE
<223>  V lambda light chain

<400>  146

Ser Glu Asp Ala Val Leu Thr Arg Thr Gln Asp Leu Arg Ser Tyr Ala 
1               5                   10                  15      


Lys Gln Val Val Gly Lys Asn 
            20              


<210>  147
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  lm6

<220>
<221>  MISC_FEATURE
<223>  V lambda light chain

<400>  147

Asn Phe Met His Glu Ser Lys Thr Thr Arg Gly Ser Ala Ser Gln Arg 
1               5                   10                  15      


Ser Ser Thr Thr Val Asp Gln Val Ile Asp Ser Ser Asn Ser Thr Ser 
            20                  25                  30          


Lys Glu Gln Ser Tyr Asn 
        35              


<210>  148
<211>  57
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  lm7

<220>
<221>  MISC_FEATURE
<223>  V lambda light chain

<400>  148

Thr Val Glu Leu Thr Val Ser Gly Thr Leu Thr Ala Ser Thr Gly Ala 
1               5                   10                  15      


Val Thr Ser Gly Tyr Pro Asn Phe Lys Gln Arg Ala Ser Thr Ser Asn 
            20                  25                  30          


Lys His Trp Thr Ala Leu Leu Gly Lys Ala Thr Leu Ser Val Pro Glu 
        35                  40                  45              


Glu Leu Leu Tyr Tyr Gly Gly Ala Gln 
    50                  55          


<210>  149
<211>  50
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  lm8

<220>
<221>  MISC_FEATURE
<223>  V lambda light chain

<400>  149

Leu Ser Ala Ser Leu Ala Ser Lys Leu Thr Thr Leu Gly His Ser Ser 
1               5                   10                  15      


Tyr Ala Ile Ala His Gln Glu Lys Gly Arg Tyr Met Lys Leu Ser Asp 
            20                  25                  30          


Gly Gly Asp Ser Ala Glu Arg Tyr Thr Ser Ser Ser Glu Gln Gly Thr 
        35                  40                  45              


Gly Ile 
    50  


<210>  150
<211>  98
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  V lambda Wil

<400>  150

Asn Phe Leu Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Asn Asn 
            20                  25                  30          


Tyr Val His Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Phe Glu Asp Asp His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Val Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp His 
                85                  90                  95      


Asn Asn 
        


<210>  151
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  AL V kappa fragment from amyloid protein


<220>
<221>  MISC_FEATURE
<223>  Consensus sequence derived from human amyloidogenic proteins

<400>  151

Pro Glu Asp Val 
1               


<210>  152
<211>  131
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Murine 2A4 and 8G9 v kappa light chain

<220>
<221>  SIGNAL
<222>  (1)..(19)
<223>  Leader sequence

<220>
<221>  mat_peptide
<222>  (20)..(131)

<220>
<221>  MISC_FEATURE
<222>  (43)..(58)
<223>  CDR 1

<220>
<221>  MISC_FEATURE
<222>  (74)..(80)
<223>  CDR 2

<220>
<221>  MISC_FEATURE
<222>  (113)..(121)
<223>  CDR 3

<400>  152

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
                -15                 -10                 -5      


Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
        -1  1               5                   10              


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
    15                  20                  25                  


Val His Ser Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
30                  35                  40                  45  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
                50                  55                  60      


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr 
            65                  70                  75          


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
        80                  85                  90              


Ser Gln Ser Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu 
    95                  100                 105                 


Glu Ile Lys 
110         


<210>  153
<211>  131
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Murine 7D8 v kappa light chain

<220>
<221>  SIGNAL
<222>  (1)..(19)
<223>  Leader sequence

<220>
<221>  mat_peptide
<222>  (20)..(131)

<220>
<221>  MISC_FEATURE
<222>  (43)..(58)
<223>  CDR 1

<220>
<221>  MISC_FEATURE
<222>  (74)..(80)
<223>  CDR 2

<220>
<221>  MISC_FEATURE
<222>  (113)..(121)
<223>  CDR 3

<400>  153

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
                -15                 -10                 -5      


Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
        -1  1               5                   10              


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Leu Ser Leu 
    15                  20                  25                  


Val His Ser Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
30                  35                  40                  45  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
                50                  55                  60      


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr 
            65                  70                  75          


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
        80                  85                  90              


Ser Gln Ser Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu 
    95                  100                 105                 


Glu Ile Lys 
110         


<210>  154
<211>  138
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Murine 2A4, 8G9 and 7D8 v heavy chain

<220>
<221>  SIGNAL
<222>  (1)..(19)
<223>  Leader sequence

<220>
<221>  mat_peptide
<222>  (20)..(138)

<220>
<221>  MISC_FEATURE
<222>  (45)..(54)
<223>  CDR 1

<220>
<221>  MISC_FEATURE
<222>  (69)..(87)
<223>  CDR 2

<220>
<221>  MISC_FEATURE
<222>  (120)..(127)
<223>  CDR 3

<400>  154

Met Val Leu Gly Leu Lys Trp Val Phe Phe Val Val Phe Tyr Gln Gly 
                -15                 -10                 -5      


Val His Cys Glu Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln 
        -1  1               5                   10              


Pro Lys Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
    15                  20                  25                  


Asn Thr Tyr Ala Met Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu 
30                  35                  40                  45  


Glu Trp Val Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Ile Tyr 
                50                  55                  60      


Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Phe Arg Asp Asp Ser 
            65                  70                  75          


Gln Ser Met Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
        80                  85                  90              


Ala Met Tyr Tyr Cys Val Arg Pro Tyr Ser Asp Ser Phe Ala Tyr Trp 
    95                  100                 105                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
110                 115                 


<210>  155
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized 2A4 and 8G9 v kappa light chain version 1

<400>  155

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  156
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized 2A4 and 8G9 v kappa light chain version 2

<400>  156

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  157
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized 2A4 and 8G9 v kappa light chain version 3

<400>  157

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  158
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized 7D8 v kappa light chain version 1

<400>  158

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Leu Ser Leu Val His Ser 
            20                  25                  30          


Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  159
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized 7D8 v kappa light chain version 2

<400>  159

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Leu Ser Leu Val His Ser 
            20                  25                  30          


Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  160
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized 7D8 v kappa light chain version 3

<400>  160

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Leu Ser Leu Val His Ser 
            20                  25                  30          


Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  161
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized 2A4, 8G9 and 7D8 heavy chain version 1

<400>  161

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Phe Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Pro Tyr Ser Asp Ser Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  162
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized 2A4, 8G9 and 7D8 heavy chain version 2

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Pro Tyr Ser Asp Ser Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  163
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized 2A4, 7D8 and 8g9 heavy chain version 3

<400>  163

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Pro Tyr Ser Asp Ser Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  164
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  164

Glu Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Phe Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Pro Tyr Ser Asp Ser Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  165
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human heavy chain framework

<400>  165

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Thr Arg Asn Lys Ala Asn Ser Tyr Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Tyr Val Val Gly Ala Thr Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  166
<211>  113
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human v kappa light chain framework

<400>  166

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  167
<211>  276
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human v kappa light chain framework

<400>  167

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Asp Val Val Met Thr Gln Ser Pro Leu Ser 
            20                  25                  30          


Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              


Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn 
65                  70                  75                  80  


Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
            100                 105                 110         


Tyr Tyr Cys Met Gln Ala Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
    130                 135                 140                 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
145                 150                 155                 160 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
                165                 170                 175     


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
    210                 215                 220                 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
225                 230                 235                 240 


Cys Ser Ala Arg Gln Ser Thr Pro Phe Val Cys Glu Tyr Gln Gly Gln 
                245                 250                 255     


Ser Ser Asp Leu Pro Gln Pro Pro Val Asn Ala Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Ser Gly 
        275     


<210>  168
<211>  16
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  2A4 VL CDR1

<400>  168

Arg Ser Ser Gln Ser Leu Val His Ser Thr Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  169
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  2A4 VL CDR2

<400>  169

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  170
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  2A4 VL CDR3

<400>  170

Ser Gln Ser Thr His Val Pro Phe Thr 
1               5                   


<210>  171
<211>  10
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  2A4 VH CDR1

<400>  171

Gly Phe Thr Phe Asn Thr Tyr Ala Met Tyr 
1               5                   10  


<210>  172
<211>  19
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  2A4 VH CDR2

<400>  172

Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Ile Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  173
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  2A4 VH CDR3

<400>  173

Pro Tyr Ser Asp Ser Phe Ala Tyr 
1               5               


<210>  174
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized 7D8 v kappa light chain version 4

<400>  174

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Leu Ser Leu Val His Ser 
            20                  25                  30          


Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  175
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized 7D8 v kappa light chain version 5

<400>  175

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Leu Ser Leu Val His Ser 
            20                  25                  30          


Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  176
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized 7D8 v kappa light chain version 6

<400>  176

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Leu Ser Leu Val His Ser 
            20                  25                  30          


Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  177
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  177

Arg Ser Ser Leu Ser Leu Val His Ser Thr Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


