                         SEQUENCE LISTING

<110>  Dana Farber Cancer Institute, Inc.
       THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
       Marasco, Wayne
       Sui, Jinhua
       Zhu, Quan
       Kupper, Thomas
 
<120>  Humanized CCR4 Monoclonal Antibodies and Methods of Use

<130>  20363-048001WO

<140>  PCT/US 08/000000
<141>  2008-12-29

<150>  61/017,494
<151>  2007-12-28

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  1
caggtgcagc tggtgcagag cggagccgag gtgaagaagc ctggagcttc cgtcaaggtg       60

tcctgcaagg ccagcggcta caccttcgcc agctactaca tgcactggat gcggcaggca      120

cctggacagg gcctcgaatg gatcggctgg atcaaccccg gcaacgtgaa caccaagtac      180

aacgagaagt tcaagggcag ggccaccctg accgtggaca ccagcaccaa caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccgtgt actactgcgc cagaagcacc      300

tactaccggc ccctggacta ctggggccag ggcaccctgg tgaccgtgag cagc            354


<210>  2
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Tyr Tyr Arg Pro Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  3
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  3
gacatcgtga tgacccagag ccccgacagc ctggccgtga gcctgggcga gcgggccacc       60

atcaactgca agagcagcca gagcatcctg tacagcagca accagaagaa ctacctggcc      120

tggtatcagc agaagcccgg ccagagcccc aagctgctga tctactgggc cagcacccgg      180

gagagcggcg tgcccgaccg gtttagcggc agcggctccg gcaccgactt caccctgacc      240

atcagcagcc tgcaggccga ggacgtggcc gtgtactact gccaccagta cctgagcagc      300

tacaccttcg gccagggcac aaagctggaa atcaag                                336


<210>  4
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Ile Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  5
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Tyr Thr Phe Ala Ser Tyr Tyr 
1               5               


<210>  6
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  6

Trp Ile Asn Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Thr Tyr Tyr Arg Pro Leu Asp Tyr 
1               5                   


<210>  8
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys Ser Ser Gln Ser Ile Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  9

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  10
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  10

His Gln Tyr Leu Ser Ser Tyr Thr 
1               5               


<210>  11
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Trp Ile Asn Xaa Xaa Asn Xaa Asn Xaa Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Ser Xaa Tyr Xaa Xaa Pro Leu Asp Xaa 
1               5                   


<210>  13
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Lys Ser Ser Gln Ser Xaa Leu Tyr Ser Xaa Xaa Xaa Xaa Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  14
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Trp Ala Ser Xaa Xaa Glu Ser 
1               5           


<210>  15
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

His Gln Tyr Leu Xaa Xaa Tyr Thr 
1               5               





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