                               SEQUENCE LISTING                               

<110> ABBOTT LABORATORIES
      BROPHY, SUSAN E.
      HAWKSWORTH, DAVID      
      SHAH, DINESH O.
      SIEGEL, ROBERT W.
      TIEMAN, BRYAN c.
      TU, BAILIN
      TYNER, JOAN D.
      ZIEMANN, ROBERT N.
     

<120> ANTI-T. CRUZI ANTIBODIES AND METHODS OF USE

<130> 8506WOO1

<140>
<141>

<150> 61/017,071
<151> 2007-12-27

<150> 
<151> 2008-12-23

<160> 28                            

<170> PatentIn Ver. 3.3

<210> 1
<211> 1518
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
atggcccagc tccaacaggc agaaaataat atcactaatt ccaaaaaaga aatgacaaag 60    
ctacgagaaa aagtgaaaaa ggccgagaaa gaaaaattgg acgccattaa ccgggcaacc 120   
aagctggaag aggaacgaaa ccaagcgtac aaagcagcac acaaggcaga ggaggaaaag 180   
gctaaaacat ttcaacgcct tataacattt gagtcggaaa atattaactt aaagaaaagg 240   
ccaaatgacg cagtttcaaa tcgggataag aaaaaaaatt ctgaaaccgc aaaaactgac 300   
gaagtagaga aacagagggc ggctgaggct gccaaggccg tggagacgga gaagcagagg 360   
gcagctgagg ccacgaaggt tgccgaagcg gagaagcgga aggcagctga ggccgccaag 420   
gccgtggaga cggagaagca gagggcagct gaagccacga aggttgccga agcggagaag 480   
cagaaggcag ctgaggccgc caaggccgtg gagacggaga agcagagggc agctgaagcc 540   
acgaaggttg ccgaagcgga gaagcagagg gcagctgaag ccatgaaggt tgccgaagcg 600   
gagaagcaga aggcagctga ggccgccaag gccgtggaga cggagaagca gagggcagct 660   
gaagccacga aggttgccga agcggagaag cagaaggcag ctgaggccgc caaggccgtg 720   
gagacggaga agcagagggc agctgaagcc acgaaggttg ccgaagcgga gaagcagaag 780   
gcagctgagg ccgccaaggc cgtggagacg gagaagcaga gggcagctga agccacgaag 840   
gttgccgaag cggagaagga tatcgatccc atgggtgctt gtgggtcgaa ggactcgacg 900   
agcgacaagg ggttggcgag cgataaggac ggcaagaacg ccaaggaccg caaggaagcg 960   
tgggagcgca ttcgccaggc gattcctcgt gagaagaccg ccgaggcaaa acagcgccgc 1020  
atcgagctct tcaagaagtt cgacaagaac gagaccggga agctgtgcta cgatgaggtg 1080  
cacagcggct gcctcgaggt gctgaagttg gacgagttca cgccgcgagt gcgcgacatc 1140  
acgaagcgtg cattcgacaa ggcgagggcc ctgggcagca agctggagaa caagggctcc 1200  
gaggactttg ttgaatttct ggagttccgt ctgatgctgt gctacatcta cgacttcttc 1260  
gagctgacgg tgatgttcga cgagattgac gcctccggca acatgctggt tgacgaggag 1320  
gagttcaagc gcgccgtgcc caggcttgag gcgtggggcg ccaaggtcga ggatcccgcg 1380  
gcgctgttca aggagctcga taagaacggc actgggtccg tgacgttcga cgagtttgct 1440  
gcgtgggctt ctgcagtcaa actggacgcc gacggcgacc cggacaacgt gccggagagc 1500  
ccgagaccga tgggaatc                                               1518  


<210> 2
<211> 506
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Ala Gln Leu Gln Gln Ala Glu Asn Asn Ile Thr Asn Ser Lys Lys  
  1               5                  10                  15    

Glu Met Thr Lys Leu Arg Glu Lys Val Lys Lys Ala Glu Lys Glu Lys  
             20                  25                  30        

Leu Asp Ala Ile Asn Arg Ala Thr Lys Leu Glu Glu Glu Arg Asn Gln  
         35                  40                  45            

Ala Tyr Lys Ala Ala His Lys Ala Glu Glu Glu Lys Ala Lys Thr Phe  
     50                  55                  60                

Gln Arg Leu Ile Thr Phe Glu Ser Glu Asn Ile Asn Leu Lys Lys Arg  
 65                  70                  75                  80

Pro Asn Asp Ala Val Ser Asn Arg Asp Lys Lys Lys Asn Ser Glu Thr  
                 85                  90                  95    

Ala Lys Thr Asp Glu Val Glu Lys Gln Arg Ala Ala Glu Ala Ala Lys  
            100                 105                 110        

Ala Val Glu Thr Glu Lys Gln Arg Ala Ala Glu Ala Thr Lys Val Ala  
        115                 120                 125            

Glu Ala Glu Lys Arg Lys Ala Ala Glu Ala Ala Lys Ala Val Glu Thr  
    130                 135                 140                

Glu Lys Gln Arg Ala Ala Glu Ala Thr Lys Val Ala Glu Ala Glu Lys  
145                 150                 155                 160

Gln Lys Ala Ala Glu Ala Ala Lys Ala Val Glu Thr Glu Lys Gln Arg  
                165                 170                 175    

Ala Ala Glu Ala Thr Lys Val Ala Glu Ala Glu Lys Gln Arg Ala Ala  
            180                 185                 190        

Glu Ala Met Lys Val Ala Glu Ala Glu Lys Gln Lys Ala Ala Glu Ala  
        195                 200                 205            

Ala Lys Ala Val Glu Thr Glu Lys Gln Arg Ala Ala Glu Ala Thr Lys  
    210                 215                 220                

Val Ala Glu Ala Glu Lys Gln Lys Ala Ala Glu Ala Ala Lys Ala Val  
225                 230                 235                 240

Glu Thr Glu Lys Gln Arg Ala Ala Glu Ala Thr Lys Val Ala Glu Ala  
                245                 250                 255    

Glu Lys Gln Lys Ala Ala Glu Ala Ala Lys Ala Val Glu Thr Glu Lys  
            260                 265                 270        

Gln Arg Ala Ala Glu Ala Thr Lys Val Ala Glu Ala Glu Lys Asp Ile  
        275                 280                 285            

Asp Pro Met Gly Ala Cys Gly Ser Lys Asp Ser Thr Ser Asp Lys Gly  
    290                 295                 300                

Leu Ala Ser Asp Lys Asp Gly Lys Asn Ala Lys Asp Arg Lys Glu Ala  
305                 310                 315                 320

Trp Glu Arg Ile Arg Gln Ala Ile Pro Arg Glu Lys Thr Ala Glu Ala  
                325                 330                 335    

Lys Gln Arg Arg Ile Glu Leu Phe Lys Lys Phe Asp Lys Asn Glu Thr  
            340                 345                 350        

Gly Lys Leu Cys Tyr Asp Glu Val His Ser Gly Cys Leu Glu Val Leu  
        355                 360                 365            

Lys Leu Asp Glu Phe Thr Pro Arg Val Arg Asp Ile Thr Lys Arg Ala  
    370                 375                 380                

Phe Asp Lys Ala Arg Ala Leu Gly Ser Lys Leu Glu Asn Lys Gly Ser  
385                 390                 395                 400

Glu Asp Phe Val Glu Phe Leu Glu Phe Arg Leu Met Leu Cys Tyr Ile  
                405                 410                 415    

Tyr Asp Phe Phe Glu Leu Thr Val Met Phe Asp Glu Ile Asp Ala Ser  
            420                 425                 430        

Gly Asn Met Leu Val Asp Glu Glu Glu Phe Lys Arg Ala Val Pro Arg  
        435                 440                 445            

Leu Glu Ala Trp Gly Ala Lys Val Glu Asp Pro Ala Ala Leu Phe Lys  
    450                 455                 460                

Glu Leu Asp Lys Asn Gly Thr Gly Ser Val Thr Phe Asp Glu Phe Ala  
465                 470                 475                 480

Ala Trp Ala Ser Ala Val Lys Leu Asp Ala Asp Gly Asp Pro Asp Asn  
                485                 490                 495    

Val Pro Glu Ser Pro Arg Pro Met Gly Ile                          
            500                 505    


<210> 3
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
ggtgacaaac catcaccatt tggacaggcc gcagcaggtg acaaaccatc accatttgga 60    
caggcc                                                            66    


<210> 4
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Gly Asp Lys Pro Ser Pro Phe Gly Gln Ala Ala Ala Gly Asp Lys Pro  
  1               5                  10                  15    

Ser Pro Phe Gly Gln Ala                                          
             20        


<210> 5
<211> 1557
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
gatccaacgt atcgttttgc aaaccacgcg ttcacgctgg tggcgtcggt gacgattcac 60    
gaggttccga gcgtcgcgag tcctttgctg ggtgcgagcc tggactcttc tggtggcaaa 120   
aaactcctgg ggctctcgta cgacgagaag caccagtggc agccaatata cggatcaacg 180   
ccggtgacgc cgaccggatc gtgggagatg ggtaagaggt accacgtggt tcttacgatg 240   
gcgaataaaa ttggctccgt gtacattgat ggagaacctc tggagggttc agggcagacc 300   
gttgtgccag acgagaggac gcctgacatc tcccacttct acgttggcgg gtatggaagg 360   
agtgatatgc caaccataag ccacgtgacg gtgaataatg ttcttcttta caaccgtcag 420   
ctgaatgccg aggagatcag gaccttgttc ttgagccagg acctgattgg cacggaagca 480   
cacatgggca gcagcagcgg cagcagtgcc cacggtacgc cctcgattcc cgttgacagc 540   
agtgcccacg gtacaccctc gactcccgtt gacagcagtg cccacggtac gccctcgact 600   
cccgttgaca gcagtgccca cggtacaccc tcgactcccg ttgacagcag tgcccacggt 660   
acaccctcga ctcccgttga cagcagtgcc cacggtaagc cctcgactcc cgctgacagc 720   
agtgcccaca gtacgccctc gactcccgct gacagcagtg cccacagtac gccctcaatt 780   
cccgctgaca gcagtgccca cagtacgccc tcagctcccg ctgacaacgg cgccaatggt 840   
acggttttga ttttgtcgac tcatgacgcg tacaggcccg ttgatccctc ggcgtacaag 900   
cgcgccttgc cgcaggaaga gcaagaggat gtggggccgc gccacgttga tcccgaccac 960   
ttccgctcga cctcgacgac tcatgacgcg tacaggcccg ttgatccctc ggcgtacaag 1020  
cgcgccttgc cgcaggaaga gcaagaggat gtggggccgc gccacgttga tcccgaccac 1080  
ttccgctcga cgactcatga cgcgtacagg cccgttgatc cctcggcgta caagcgcgcc 1140  
ttgccgcagg aagagcaaga ggatgtgggg ccgcgccacg ttgatcccga ccacttccgc 1200  
tcgacctcga cgactcatga cgcgtacagg cccgttgatc cctcggcgta caagcgcgcc 1260  
ttgccgcagg aagagcaaga ggatgtgggg ccgcgccacg ttgatcccga ccacttccgc 1320  
tcgacctcga cgactcatga cgcgtacagg cccgttgatc cctcggcgta caagcgcgcc 1380  
ttgccgcagg aagagcaaga ggatgtgggg ccgcgccacg ttgatcccga ccacttccgc 1440  
tcgacgactc atgacgcgta caggcccgtt gatccctcgg cgtacaagcg cgccttgccg 1500  
caggaagagc aagaggatgt ggggccgcgc cacgttgatc ccgaccactt ccgctcg    1557  


<210> 6
<211> 519
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Asp Pro Thr Tyr Arg Phe Ala Asn His Ala Phe Thr Leu Val Ala Ser  
  1               5                  10                  15    

Val Thr Ile His Glu Val Pro Ser Val Ala Ser Pro Leu Leu Gly Ala  
             20                  25                  30        

Ser Leu Asp Ser Ser Gly Gly Lys Lys Leu Leu Gly Leu Ser Tyr Asp  
         35                  40                  45            

Glu Lys His Gln Trp Gln Pro Ile Tyr Gly Ser Thr Pro Val Thr Pro  
     50                  55                  60                

Thr Gly Ser Trp Glu Met Gly Lys Arg Tyr His Val Val Leu Thr Met  
 65                  70                  75                  80

Ala Asn Lys Ile Gly Ser Val Tyr Ile Asp Gly Glu Pro Leu Glu Gly  
                 85                  90                  95    

Ser Gly Gln Thr Val Val Pro Asp Glu Arg Thr Pro Asp Ile Ser His  
            100                 105                 110        

Phe Tyr Val Gly Gly Tyr Gly Arg Ser Asp Met Pro Thr Ile Ser His  
        115                 120                 125            

Val Thr Val Asn Asn Val Leu Leu Tyr Asn Arg Gln Leu Asn Ala Glu  
    130                 135                 140                

Glu Ile Arg Thr Leu Phe Leu Ser Gln Asp Leu Ile Gly Thr Glu Ala  
145                 150                 155                 160

His Met Gly Ser Ser Ser Gly Ser Ser Ala His Gly Thr Pro Ser Ile  
                165                 170                 175    

Pro Val Asp Ser Ser Ala His Gly Thr Pro Ser Thr Pro Val Asp Ser  
            180                 185                 190        

Ser Ala His Gly Thr Pro Ser Thr Pro Val Asp Ser Ser Ala His Gly  
        195                 200                 205            

Thr Pro Ser Thr Pro Val Asp Ser Ser Ala His Gly Thr Pro Ser Thr  
    210                 215                 220                

Pro Val Asp Ser Ser Ala His Gly Lys Pro Ser Thr Pro Ala Asp Ser  
225                 230                 235                 240

Ser Ala His Ser Thr Pro Ser Thr Pro Ala Asp Ser Ser Ala His Ser  
                245                 250                 255    

Thr Pro Ser Ile Pro Ala Asp Ser Ser Ala His Ser Thr Pro Ser Ala  
            260                 265                 270        

Pro Ala Asp Asn Gly Ala Asn Gly Thr Val Leu Ile Leu Ser Thr His  
        275                 280                 285            

Asp Ala Tyr Arg Pro Val Asp Pro Ser Ala Tyr Lys Arg Ala Leu Pro  
    290                 295                 300                

Gln Glu Glu Gln Glu Asp Val Gly Pro Arg His Val Asp Pro Asp His  
305                 310                 315                 320

Phe Arg Ser Thr Ser Thr Thr His Asp Ala Tyr Arg Pro Val Asp Pro  
                325                 330                 335    

Ser Ala Tyr Lys Arg Ala Leu Pro Gln Glu Glu Gln Glu Asp Val Gly  
            340                 345                 350        

Pro Arg His Val Asp Pro Asp His Phe Arg Ser Thr Thr His Asp Ala  
        355                 360                 365            

Tyr Arg Pro Val Asp Pro Ser Ala Tyr Lys Arg Ala Leu Pro Gln Glu  
    370                 375                 380                

Glu Gln Glu Asp Val Gly Pro Arg His Val Asp Pro Asp His Phe Arg  
385                 390                 395                 400

Ser Thr Ser Thr Thr His Asp Ala Tyr Arg Pro Val Asp Pro Ser Ala  
                405                 410                 415    

Tyr Lys Arg Ala Leu Pro Gln Glu Glu Gln Glu Asp Val Gly Pro Arg  
            420                 425                 430        

His Val Asp Pro Asp His Phe Arg Ser Thr Ser Thr Thr His Asp Ala  
        435                 440                 445            

Tyr Arg Pro Val Asp Pro Ser Ala Tyr Lys Arg Ala Leu Pro Gln Glu  
    450                 455                 460                

Glu Gln Glu Asp Val Gly Pro Arg His Val Asp Pro Asp His Phe Arg  
465                 470                 475                 480

Ser Thr Thr His Asp Ala Tyr Arg Pro Val Asp Pro Ser Ala Tyr Lys  
                485                 490                 495    

Arg Ala Leu Pro Gln Glu Glu Gln Glu Asp Val Gly Pro Arg His Val  
            500                 505                 510        

Asp Pro Asp His Phe Arg Ser                                      
        515                


<210> 7
<211> 213
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
atggagtcag gagcgtcaga tcagctgctc gagaaggacc cgcgtcagga acgcgaagga 60    
gattgctgcg cttgaggaga gtcatgaatg cccgcgtcat caggagctgg cgcgcgagaa 120   
gaagcttgcc gaccgcgcgt tccttgactc agaagccgga gcgcgtgccg ctggctgacg 180   
tgccgctcga cgacgatcag cgactttgtt gcg                              213   


<210> 8
<211> 68
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Glu Gln Glu Arg Arg Gln Leu Leu Glu Lys Asp Pro Arg Arg Asn  
  1               5                  10                  15    

Ala Lys Glu Ile Ala Ala Leu Glu Glu Ser Met Asn Ala Arg Ala Gln  
             20                  25                  30        

Glu Leu Ala Arg Glu Lys Lys Leu Ala Asp Arg Ala Phe Leu Asp Gln  
         35                  40                  45            

Lys Pro Glu Arg Val Pro Leu Ala Asp Val Pro Leu Asp Asp Asp Ser  
     50                  55                  60                

Asp Phe Val Ala                                                  
 65            


<210> 9
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
tacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact 60    
atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ccacttggct 120   
tggtatcagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg 180   
gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cgctctcacc 240   
atcagcagtg tgcaggctga agacctggca gtttatttct gcaagcaatc ttataatctg 300   
tacacattcg gtgctgggac caagctggag ctgaaa                           336   


<210> 10
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polypeptide 

<400> 10
Tyr Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly  
  1               5                  10                  15    

Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser  
             20                  25                  30        

Arg Thr Arg Lys Asn His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln  
         35                  40                  45            

Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val  
     50                  55                  60                

Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr  
 65                  70                  75                  80

Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Lys Gln  
                 85                  90                  95    

Ser Tyr Asn Leu Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys  
            100                 105                 110        

                                                                 



<210> 11
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
gatgtgcagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc ccggaaactc 60    
tcctgtgcag cctctggatt cactttcagt gtctttggaa tgcactgggt tcgtcaggct 120   
ccagagaagg ggctggagtg ggtcgcatac attagtagtg gcagtactat catctattat 180   
gcagacacag tgaagggccg attcaccatc tccagagaca atcccaagaa caccctgttc 240   
ctgcaaatga ccggtctaag gtctgaggac acggccatgt attactgtgc aagaccgctc 300   
tactatgatt acgacgacta tgctatggac tactggggtc aaggaacctc agtcaccgtc 360   
tcctca                                                            366   


<210> 12
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polypeptide 

<400> 12
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly  
  1               5                  10                  15    

Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Phe  
             20                  25                  30        

Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val  
         35                  40                  45            

Ala Tyr Ile Ser Ser Gly Ser Thr Ile Ile Tyr Tyr Ala Asp Thr Val  
     50                  55                  60                

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe  
 65                  70                  75                  80

Leu Gln Met Thr Gly Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys  
                 85                  90                  95    

Ala Arg Pro Leu Tyr Tyr Asp Tyr Asp Asp Tyr Ala Met Asp Tyr Trp  
            100                 105                 110        

Gly Gln Gly Thr Ser Val Thr Val Ser Ser                          
        115                 120        


<210> 13
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gcaggtcact 60    
atgagctgca aatccagtca gagtctgttc aacagtagaa cccgaaagaa ctacttggct 120   
tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg 180   
gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc 240   
atcagcagtg tgcaggctga agacctggca gtttattact gcaaacaatc ttataatctg 300   
ctcacgttcg gtgctgggac caagctggag ctgaaa                           336   


<210> 14
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polypeptide 

<400> 14
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly  
  1               5                  10                  15    

Glu Gln Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser  
             20                  25                  30        

Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln  
         35                  40                  45            

Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val  
     50                  55                  60                

Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr  
 65                  70                  75                  80

Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln  
                 85                  90                  95    

Ser Tyr Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys  
            100                 105                 110        

                                                                 



<210> 15
<211> 360
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
caggtccaac tgcagcagcc tggggctgaa ctggtgaggc ctggggcttc agtgaaactg 60    
tcctgcaagg cttctggcta caccttcacc agctactgga tgaactgggt gaagttgagg 120   
cctggacaag gccttgaatg gattggtatg attgatcctt cagacagtga aacttactac 180   
gatcaagtat tcaaggacaa ggccacattg actgttgaca aatcctccag cacagcctac 240   
atgcatctca gcagcctgac atctgaggac tctgcggtct attactgtgc aagatggatt 300   
acgactgatt cctatactat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca 360   


<210> 16
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polypeptide 

<400> 16
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala  
  1               5                  10                  15    

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr  
             20                  25                  30        

Trp Met Asn Trp Val Lys Leu Arg Pro Gly Gln Gly Leu Glu Trp Ile  
         35                  40                  45            

Gly Met Ile Asp Pro Ser Asp Ser Glu Thr Tyr Tyr Asp Gln Val Phe  
     50                  55                  60                

Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr  
 65                  70                  75                  80

Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys  
                 85                  90                  95    

Ala Arg Trp Ile Thr Thr Asp Ser Tyr Thr Met Asp Tyr Trp Gly Gln  
            100                 105                 110        

Gly Thr Ser Val Thr Val Ser Ser                                  
        115                 120


<210> 17
<211> 335
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc 60    
atctcttgca gatctagtca gagccttgta cacagtaatg gaaaccctat ttacattggt 120   
acctgcagaa gccaggccag tctccaaagc tcctgatcta caaagtttcc aaccgatttt 180   
ctggggtccc agacaggttc agtggcagtg gatcagggac agatttcaca ctcaagatca 240   
gcagagtgga ggctgaggat ctgggagttt atttctgctc tcaaagtaca catgttcctc 300   
cgacgttcgg tggaggcacc aagctggaaa tcaaa                            335   


<210> 18
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polypeptide 

<400> 18
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly  
  1               5                  10                  15    

Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser  
             20                  25                  30        

Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser  
         35                  40                  45            

Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro  
     50                  55                  60                

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile  
 65                  70                  75                  80

Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser  
                 85                  90                  95    

Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys  
            100                 105                 110        

                                                                 



<210> 19
<211> 359
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
caggtccaac tgcagcagcc tggggctgag ctggtgaagc ctggggcttc agtgaagatg 60    
tcctgcaagg cttctggcta caccttcacc agctactggg tgcactgggt gaagcagagg 120   
cctggacaag gccttgagtg gatcggagtg attgatcctt ctgatagtta tactagctac 180   
aatcaaaagt tcaagggcaa ggccacatta ctgtagacac atcctccagc acagcctaca 240   
tgcagctcag cagcctgaca tctgaggact ctgcggtcta ttactgtaca agacactatg 300   
atttcgacag ctggtacttc gatgtctggg gcgcagggac cacggtcacc gtctcctca  359   


<210> 20
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      polypeptide 

<400> 20
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala  
  1               5                  10                  15    

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr  
             20                  25                  30        

Trp Val His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile  
         35                  40                  45            

Gly Val Ile Asp Pro Ser Asp Ser Tyr Thr Ser Tyr Asn Gln Lys Phe  
     50                  55                  60                

Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr  
 65                  70                  75                  80

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys  
                 85                  90                  95    

Thr Arg His Tyr Asp Phe Asp Ser Trp Tyr Phe Asp Val Trp Gly Ala  
            100                 105                 110        

Gly Thr Thr Val Thr Val Ser Ser                                  
        115                 120


<210> 21
<211> 1415
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      polynucleotide

<400> 21
tggagtttgg gctgagctgg ctttttcttg tcgcgatttt aaaaggtgtc cagtgcgatg 60    
tgcagctggt ggagtctggg ggaggcttag tgcagcctgg agggtcccgg aaactctcct 120   
gtgcagcctc tggattcact ttcagtgtct ttggaatgca ctgggttcgt caggctccag 180   
agaaggggct ggagtgggtc gcatacatta gtagtggcag tactatcatc tattatgcag 240   
acacagtgaa gggccgattc accatctcca gagacaatcc caagaacacc ctgttcctgc 300   
aaatgaccgg tctaaggtct gaggacacgg ccatgtatta ctgtgcaaga ccgctctact 360   
atgattacga cgactatgct atggactact ggggtcaagg aacctcagtc accgtctcct 420   
cagcgtcgac caagggccca tcggtcttcc ccctggcacc ctcctccaag agcacctctg 480   
ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg gtgacggtgt 540   
cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc ctacagtcct 600   
caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg ggcacccaga 660   
cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag aaagttgagc 720   
ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa ctcctggggg 780   
gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc tcccggaccc 840   
ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc aagttcaact 900   
ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag gagcagtaca 960   
acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg ctgaatggca 1020  
aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag aaaaccatct 1080  
ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca tcccgcgagg 1140  
agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat cccagcgaca 1200  
tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc acgcctcccg 1260  
tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac aagagcaggt 1320  
ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac aaccactaca 1380  
cgcagaagag cctctccctg tctccgggta aatga                            1415  


<210> 22
<211> 1415
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      polynucleotide

<400> 22
tcatttaccc ggagacaggg agaggctctt ctgcgtgtag tggttgtgca gagcctcatg 60    
catcacggag catgagaaga cgttcccctg ctgccacctg ctcttgtcca cggtgagctt 120   
gctgtagagg aagaaggagc cgtcggagtc cagcacggga ggcgtggtct tgtagttgtt 180   
ctccggctgc ccattgctct cccactccac ggcgatgtcg ctgggataga agcctttgac 240   
caggcaggtc aggctgacct ggttcttggt catctcctcg cgggatgggg gcagggtgta 300   
cacctgtggt tctcggggct gccctttggc tttggagatg gttttctcga tgggggctgg 360   
gagggctttg ttggagacct tgcacttgta ctccttgcca ttcagccagt cctggtgcag 420   
gacggtgagg acgctgacca cacggtacgt gctgttgtac tgctcctccc gcggctttgt 480   
cttggcatta tgcacctcca cgccgtccac gtaccagttg aacttgacct cagggtcttc 540   
gtggctcacg tccaccacca cgcatgtgac ctcaggggtc cgggagatca tgagggtgtc 600   
cttgggtttt ggggggaaga ggaagactga cggtcccccc aggagttcag gtgctgggca 660   
cggtgggcat gtgtgagttt tgtcacaaga tttgggctca actttcttgt ccaccttggt 720   
gttgctgggc ttgtgattca cgttgcagat gtaggtctgg gtgcccaagc tgctggaggg 780   
cacggtcacc acgctgctga gggagtagag tcctgaggac tgtaggacag ccgggaaggt 840   
gtgcacgccg ctggtcaggg cgcctgagtt ccacgacacc gtcaccggtt cggggaagta 900   
gtccttgacc aggcagccca gggccgctgt gcccccagag gtgctcttgg aggagggtgc 960   
cagggggaag accgatgggc ccttggtcga cgctgaggag acggtgactg aggttccttg 1020  
accccagtag tccatagcat agtcgtcgta atcatagtag agcggtcttg cacagtaata 1080  
catggccgtg tcctcagacc ttagaccggt catttgcagg aacagggtgt tcttgggatt 1140  
gtctctggag atggtgaatc ggcccttcac tgtgtctgca taatagatga tagtactgcc 1200  
actactaatg tatgcgaccc actccagccc cttctctgga gcctgacgaa cccagtgcat 1260  
tccaaagaca ctgaaagtga atccagaggc tgcacaggag agtttccggg accctccagg 1320  
ctgcactaag cctcccccag actccaccag ctgcacatcg cactggacac cttttaaaat 1380  
cgcgacaaga aaaagccagc tcagcccaaa ctcca                            1415  


<210> 23
<211> 725
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      polynucleotide

<400> 23
tggacatgcg cgtgcccgcc cagctgctgg gcctgctgct gctgtggttc cccggctcgc 60    
gatgctacat tgtgatgtca cagtctccat cctccctggc tgtgtcagca ggagagaagg 120   
tcactatgag ctgcaaatcc agtcagagtc tgctcaacag tagaacccga aagaaccact 180   
tggcttggta tcagcagaaa ccagggcagt ctcctaaact gctgatctac tgggcatcca 240   
ctagggaatc tggggtccct gatcgcttca caggcagtgg atctgggaca gatttcgctc 300   
tcaccatcag cagtgtgcag gctgaagacc tggcagttta tttctgcaag caatcttata 360   
atctgtacac attcggtgct gggaccaagc tggagctgaa acgtacggtg gctgcaccat 420   
ctgtcttcat cttcccgcca tctgatgagc agttgaaatc tggaactgcc tctgttgtgt 480   
gcctgctgaa taacttctat cccagagagg ccaaagtaca gtggaaggtg gataacgccc 540   
tccaatcggg taactcccag gagagtgtca cagagcagga cagcaaggac agcacctaca 600   
gcctcagcag caccctgacg ctgagcaaag cagactacga gaaacacaaa gtctacgcct 660   
gcgaagtcac ccatcagggc ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt 720   
gttga                                                             725   


<210> 24
<211> 725
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      polynucleotide

<400> 24
tcaacactct cccctgttga agctctttgt gacgggcgag ctcaggccct gatgggtgac 60    
ttcgcaggcg tagactttgt gtttctcgta gtctgctttg ctcagcgtca gggtgctgct 120   
gaggctgtag gtgctgtcct tgctgtcctg ctctgtgaca ctctcctggg agttacccga 180   
ttggagggcg ttatccacct tccactgtac tttggcctct ctgggataga agttattcag 240   
caggcacaca acagaggcag ttccagattt caactgctca tcagatggcg ggaagatgaa 300   
gacagatggt gcagccaccg tacgtttcag ctccagcttg gtcccagcac cgaatgtgta 360   
cagattataa gattgcttgc agaaataaac tgccaggtct tcagcctgca cactgctgat 420   
ggtgagagcg aaatctgtcc cagatccact gcctgtgaag cgatcaggga ccccagattc 480   
cctagtggat gcccagtaga tcagcagttt aggagactgc cctggtttct gctgatacca 540   
agccaagtgg ttctttcggg ttctactgtt gagcagactc tgactggatt tgcagctcat 600   
agtgaccttc tctcctgctg acacagccag ggaggatgga gactgtgaca tcacaatgta 660   
gcatcgcgag ccggggaacc acagcagcag caggcccagc agctgggcgg gcacgcgcat 720   
gtcca                                                             725   


<210>  25
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
gacatccaga tggaccagtc tccatccagt ctgtctgcat cccttggaga cacaattacc       60
atcacttgcc atgccagtca gaacattaat gtttggttaa gctggtacca gcagaaacca      120
ggaaatattc ctaaactatt gatctataag gcttccaact tgcacacagg cgtcccatca      180
aggtttagtg gcagtggatc tggaacaggt ttcacattaa ccatcagcag cctgcagcct      240
gaagacattg ccacttacta ctgtcaacag ggtcaaagtt atcctctcac gttcggctcg      300
gggcgaaagt tggaaataaa a                                                321


<210>  26
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Asp Ile Gln Met Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      

Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          

Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu 
                85                  90                  95      

Thr Phe Gly Ser Gly Arg Lys Leu Glu Ile Lys 
            100                 105         


<210>  27
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Artificial polynucleotide

<400>  3
gaggttcagc tgcagcagtc tggggcagag cttgtgaagc caggggcctc agtcaagttg       60
tcctgcacag cttctggctt caacattaaa gacacctata tgcactgggt gaagcagagg      120
cctgaacagg gcctggagtg gattggaagg attgatcctg cgaatggtaa tactaaatat      180
gacccgaagt tccagggcaa ggccactata acaacagaca catcctccaa cacagcctac      240
ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtgc tacctcctac      300
tatggtaact acgttgctta ctggggccac gggactctgg tcactgtctc tgca            354


<210>  28
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial polypeptide

<400>  4

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          

Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              

Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  

Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  

Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Thr Ser Tyr Tyr Gly Asn Tyr Val Ala Tyr Trp Gly His Gly Thr 
            100                 105                 110         

Leu Val Thr Val Ser Ala 
        115             


