                         SEQUENCE LISTING

<110>  Genentech Inc.
       Scales, Suzanna J.
 
<120>  Anti-Hedgehog Antibodies

<130>  P4137R1 WO

<150>  61/017,232
<151>  2007-12-28

<150>  61/099,864
<151>  2008-09-24

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  Mus musculus

<400>  1

Gln Ser Val Lys Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser 
            20                  


<210>  2
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  2

Gly Phe Ser Leu Ser Ser Tyr Asp Met Ser 
1               5                   10  


<210>  3
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  3

Trp Val Arg Gln Ala Pro Gly Ser Gly Leu Glu Trp Ile 
1               5                   10              


<210>  4
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  4

Gly Gly Ile Leu Ser Gly Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Ser 
    


<210>  5
<211>  30
<212>  PRT
<213>  Mus musculus

<400>  5

Arg Ser Thr Ile Thr Lys Asn Thr Asn Leu Asn Thr Val Thr Leu Lys 
1               5                   10                  15      


Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
            20                  25                  30  


<210>  6
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  6

Ala Arg Gly Ile Tyr Pro Val Gly Thr Asn Tyr Asn Ile 
1               5                   10              


<210>  7
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  7

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly 
1               5                   10          


<210>  8
<211>  322
<212>  PRT
<213>  Mus musculus

<400>  8

Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp 
1               5                   10                  15      


Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu 
            20                  25                  30          


Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly 
        35                  40                  45              


Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn 
65                  70                  75                  80  


Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro 
                85                  90                  95      


Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        115                 120                 125             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp 
    130                 135                 140                 


Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg 
145                 150                 155                 160 


Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg 
                165                 170                 175     


Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys 
            180                 185                 190         


Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        195                 200                 205             


Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr 
    210                 215                 220                 


Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu 
225                 230                 235                 240 


Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp 
                245                 250                 255     


Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val 
            260                 265                 270         


Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Pro 
        275                 280                 285             


Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His 
    290                 295                 300                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro 
305                 310                 315                 320 


Gly Lys 
        


<210>  9
<211>  24
<212>  PRT
<213>  Mus musculus

<400>  9

Asp Ile Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Asn Cys 
            20                  


<210>  10
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  10

Gln Ser Ser Pro Ser Val Tyr Ser Asn Tyr Leu Ala 
1               5                   10          


<210>  11
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  11

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
1               5                   10                  


<210>  12
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  12

Tyr Tyr Ala Ser Thr Leu Ala Ser 
1               5               


<210>  13
<211>  32
<212>  PRT
<213>  Mus musculus

<400>  13

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  14
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  14

Ala Gly Gly Tyr Ile Asp Thr Ser Asp Thr Ala 
1               5                   10      


<210>  15
<211>  114
<212>  PRT
<213>  Mus musculus

<400>  15

Phe Gly Gly Gly Thr Glu Val Val Val Lys Gly Asp Pro Val Ala Pro 
1               5                   10                  15      


Thr Val Leu Ile Phe Pro Pro Ala Ala Asp Gln Val Ala Thr Gly Thr 
            20                  25                  30          


Val Thr Ile Val Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val 
        35                  40                  45              


Thr Trp Glu Val Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser 
    50                  55                  60                  


Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys 
                85                  90                  95      


Lys Val Thr Gln Gly Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly 
            100                 105                 110         


Asp Cys 
        


<210>  16
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  16

Cys Gly Pro Gly Arg Gly Phe Gly Lys Arg Arg His Pro Lys Lys Leu 
1               5                   10                  15      


Thr Pro Leu Ala Tyr Lys Gln Phe Ile Pro Asn Val Ala Glu Lys Thr 
            20                  25                  30          


Leu Gly Ala Ser Gly Arg Tyr Glu Gly Lys Ile Ser Arg Asn Ser Glu 
        35                  40                  45              


Arg Phe Lys Glu Leu Thr Pro Asn Tyr Asn Pro Asp Ile Ile Phe Lys 
    50                  55                  60                  


Asp Glu Glu Asn Thr Gly Ala Asp Arg Leu Met Thr Gln Arg Cys Lys 
65                  70                  75                  80  


Asp Lys Leu Asn Ala Leu Ala Ile Ser Val Met Asn Gln Trp Pro Gly 
                85                  90                  95      


Val Lys Leu Arg Val Thr Glu Gly Trp Asp Glu Asp Gly His His Ser 
            100                 105                 110         


Glu Glu Ser Leu His Tyr Glu Gly Arg Ala Val Asp Ile Thr Thr Ser 
        115                 120                 125             


Asp Arg Asp Arg Ser Lys Tyr Gly Met Leu Ala Arg Leu Ala Val Glu 
    130                 135                 140                 


Ala Gly Phe Asp Trp Val Tyr Tyr Glu Ser Lys Ala His Ile His Cys 
145                 150                 155                 160 


Ser Val Lys Ala Glu Asn Ser Val Ala Ala Lys Ser Gly Gly 
                165                 170                 


<210>  17
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  17

Cys Gly Pro Gly Arg Val Val Gly Ser Arg Arg Arg Pro Pro Arg Lys 
1               5                   10                  15      


Leu Val Pro Leu Ala Tyr Lys Gln Phe Ser Pro Asn Val Pro Glu Lys 
            20                  25                  30          


Thr Leu Gly Ala Ser Gly Arg Tyr Glu Gly Lys Ile Ala Arg Ser Ser 
        35                  40                  45              


Glu Arg Phe Lys Glu Leu Thr Pro Asn Tyr Asn Pro Asp Ile Ile Phe 
    50                  55                  60                  


Lys Asp Glu Glu Asn Thr Gly Ala Asp Arg Leu Met Thr Gln Arg Cys 
65                  70                  75                  80  


Lys Asp Arg Leu Asn Ser Leu Ala Ile Ser Val Met Asn Gln Trp Pro 
                85                  90                  95      


Gly Val Lys Leu Arg Val Thr Glu Gly Trp Asp Glu Asp Gly His His 
            100                 105                 110         


Ser Glu Glu Ser Leu His Tyr Glu Gly Arg Ala Val Asp Ile Thr Thr 
        115                 120                 125             


Ser Asp Arg Asp Arg Asn Lys Tyr Gly Leu Leu Ala Arg Leu Ala Val 
    130                 135                 140                 


Glu Ala Gly Phe Asp Trp Val Tyr Tyr Glu Ser Lys Ala His Val His 
145                 150                 155                 160 


Cys Ser Val Lys Ser Glu His Ser Ala Ala Ala Lys Thr Gly Gly 
                165                 170                 175 


<210>  18
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  18

Cys Gly Pro Gly Arg Gly Pro Val Gly Arg Arg Arg Tyr Ala Arg Lys 
1               5                   10                  15      


Gln Leu Val Pro Leu Leu Tyr Lys Gln Phe Val Pro Gly Val Pro Glu 
            20                  25                  30          


Arg Thr Leu Gly Ala Ser Gly Pro Ala Glu Gly Arg Val Ala Arg Gly 
        35                  40                  45              


Ser Glu Arg Phe Arg Asp Leu Val Pro Asn Tyr Asn Pro Asp Ile Ile 
    50                  55                  60                  


Phe Lys Asp Glu Glu Asn Ser Gly Ala Asp Arg Leu Met Thr Glu Arg 
65                  70                  75                  80  


Cys Lys Glu Arg Val Asn Ala Leu Ala Ile Ala Val Met Asn Met Trp 
                85                  90                  95      


Pro Gly Val Arg Leu Arg Val Thr Glu Gly Trp Asp Glu Asp Gly His 
            100                 105                 110         


His Ala Gln Asp Ser Leu His Tyr Glu Gly Arg Ala Leu Asp Ile Thr 
        115                 120                 125             


Thr Ser Asp Arg Asp Arg Asn Lys Tyr Gly Leu Leu Ala Arg Leu Ala 
    130                 135                 140                 


Val Glu Ala Gly Phe Asp Trp Val Tyr Tyr Glu Ser Arg Asn His Val 
145                 150                 155                 160 


His Val Ser Val Lys Ala Asp Asn Ser Leu Ala Val Arg Ala Gly Gly 
                165                 170                 175     


