                         SEQUENCE LISTING

<110>  Wyeth
       Christopher, Parks L.
       Witko, Susan E.
       Sidhu, Maninder
       Johnson, Erik J.
       Hendry, Roger M.
 
<120>  METHODS FOR PACKAGING PROPAGATION-DEFECTIVE VESICULAR STOMATITIS 
       VIRUS VECTORS USING A STABLE CELL LINE THAT EXPRESSES G PROTEIN

<130>  AM102924

<150>  US 61/015353
<151>  2007-12-20

<160>  13    

<170>  PatentIn version 3.4

<210>  1
<211>  1536
<212>  DNA
<213>  Vesicular Stomatitis Indiana Virus

<400>  1
atgaagtgcc ttttgtactt agccttttta ttcattgggg tgaattgcaa gttcaccata     60

gtttttccac acaaccaaaa aggaaactgg aaaaatgttc cttctaatta ccattattgc    120

ccgtcaagct cagatttaaa ttggcataat gacttaatag gcacagcctt acaagtcaaa    180

atgcccaaga gtcacaaggc tattcaagca gacggttgga tgtgtcatgc ttccaaatgg    240

gtcactactt gtgatttccg ctggtatgga ccgaagtata taacacattc catccgatcc    300

ttcactccat ctgtagaaca atgcaaggaa agcattgaac aaacgaaaca aggaacttgg    360

ctgaatccag gcttccctcc tcaaagttgt ggatatgcaa ctgtgacgga tgccgaagca    420

gtgattgtcc aggtgactcc tcaccatgtg ctggttgatg aatacacagg agaatgggtt    480

gattcacagt tcatcaacgg aaaatgcagc aattacatat gccccactgt ccataactct    540

acaacctggc attctgacta taaggtcaaa gggctatgtg attctaacct catttccatg    600

gacatcacct tcttctcaga ggacggagag ctatcatccc tgggaaagga gggcacaggg    660

ttcagaagta actactttgc ttatgaaact ggaggcaagg cctgcaaaat gcaatactgc    720

aagcattggg gagtcagact cccatcaggt gtctggttcg agatggctga taaggatctc    780

tttgctgcag ccagattccc tgaatgccca gaagggtcaa gtatctctgc tccatctcag    840

acctcagtgg atgtaagtct aattcaggac gttgagagga tcttggatta ttccctctgc    900

caagaaacct ggagcaaaat cagagcgggt cttccaatct ctccagtgga tctcagctat    960

cttgctccta aaaacccagg aaccggtcct gctttcacca taatcaatgg taccctaaaa   1020

tactttgaga ccagatacat cagagtcgat attgctgctc caatcctctc aagaatggtc   1080

ggaatgatca gtggaactac cacagaaagg gaactgtggg atgactgggc accatatgaa   1140

gacgtggaaa ttggacccaa tggagttctg aggaccagtt caggatataa gtttccttta   1200

tacatgattg gacatggtat gttggactcc gatcttcatc ttagctcaaa ggctcaggtg   1260

ttcgaacatc ctcacattca agacgctgct tcgcaacttc ctgatgatga gagtttattt   1320

tttggtgata ctgggctatc caaaaatcca atcgagcttg tagaaggttg gttcagtagt   1380

tggaaaagct ctattgcctc ttttttcttt atcatagggt taatcattgg actattcttg   1440

gttctccgag ttggtatcca tctttgcatt aaattaaagc acaccaagaa aagacagatt   1500

tatacagaca tagagatgaa ccgacttgga aagtaa                             1536


<210>  2
<211>  1554
<212>  DNA
<213>  Vesicular Stomatitis New Jersey Virus

<400>  2
atgttgtctt atctaatctt tgcacttgcc gtttcgccca ttttgggcaa aattgaaatt     60

gtgtttcctc aacataccac tggggattgg aagagagttc cccatgaata taattattgc    120

cctaccagcg cagacaagaa ctcacatggg actcaaacag gaatccctgt tgagttaaca    180

atgccaaaag gactaacaac ccatcaagtt gaaggattta tgtgtcactc agccttgtgg    240

atgaccactt gtgacttcag atggtatggg ccaaaataca taacccattc catacataat    300

gaagagccta cagattatca atgtttggag gccattaagt catacaaaga tggagtcagt    360

ttcaatccag ggtttcctcc tcagagctgc gggtatggca cagttaccga tgccgaagcc    420

catattgtga cagttactcc ccactctgtc aaagtggacg agtacacggg ggaatggatc    480

gatccacatt tcatcggagg aaggtgcaaa ggacaaattt gtgaaacagt ccataattcc    540

acaaaatggt ttacgtcctc tgatggagaa agtgtctgca gtcaattgtt tactttggtt    600

ggaggaattt ttttctctga ttcagaagag attacctcca tggggttacc agaaacagga    660

atcagaagta attacttccc ctacatatct acagagggaa tttgcaaaat gccgttttgc    720

agaaaacagg ggtacaagct taaaaatgac ctctggttcc agatcatgga cccagacctg    780

gataaaacgg ttagagatct ccctcatatt aaggactgtg acctctcctc gtccataatc    840

acaccaggag aacatgctac agacatctca ctgatatcag atgttgaaag gatcctggac    900

tatgctcttt gtcagaatac atggagtaaa attgaatcgg gagaaccaat tactccggta    960

gatctcagct atcttgggcc aaaaaaccca ggggttgggc cggtcttcac catcattaac   1020

ggttccctgc attattttac atcgaagtat ctgcgagtcg aattagaaag tcctgtcata   1080

cccagaatgg aaggaaaagt tgcaggaact aggattgtac ggcaattgtg ggatcagtgg   1140

tttcctttcg gagaagttga gattggaccc aatggtgtgt tgaaaacgaa gcaagggtat   1200

aaattcccac tacacatcat tggaactgga gaagtagaca gtgacatcaa aatggaaagg   1260

gttgtcaagc actgggaaca cccccatatt gaggccgctc agacattttt aaaaaaagat   1320

gacacaggag aagtccttta ttatggcgac accggagtgt cgaaaaatcc agttgaatta   1380

gtcgagggat ggtttagtgg atggaggagc tccctcatgg gagtgctggc tgtgattata   1440

ggatttgtga ttttaatgtt tttaattaaa ttgattggag tcttatctag ccttttcaga   1500

cctaaacgca ggccaatcta caaatcagac gtggaaatgg ctcatttccg ttaa         1554


<210>  3
<211>  1536
<212>  DNA
<213>  Artificial

<220>
<223>  Codon Optimized VSV G protein coding sequence, Indiana serotype

<400>  3
atgaagtgcc tgctgtacct ggccttcctg ttcatcggcg tgaactgcaa gttcaccatc     60

gtgttccccc acaaccagaa gggcaactgg aagaacgtgc ccagcaacta ccactactgc    120

cccagcagca gcgacctgaa ctggcacaac gacctgatcg gcaccgccct gcaagtgaag    180

atgcccaaga gccacaaggc catccaggcc gacggctgga tgtgccacgc cagcaagtgg    240

gtgaccacct gcgacttccg gtggtacggc cccaagtaca tcacccacag catccgcagc    300

ttcaccccca gcgtggagca gtgcaaggag agcatcgagc agaccaagca gggcacctgg    360

ctgaaccccg gcttcccccc ccaaagctgc ggctacgcca ccgtgaccga cgccgaggcc    420

gtgatcgtgc aggtgacccc ccaccacgtg ctggtggacg agtacaccgg cgagtgggtg    480

gacagccagt tcatcaacgg caagtgcagc aactacatct gccccaccgt gcacaacagc    540

accacctggc acagcgacta caaggtgaag ggcctgtgcg acagcaacct gatcagcatg    600

gacatcacgt tcttcagcga ggacggcgag ctgagcagcc tgggcaagga gggcaccggc    660

ttccgcagca actacttcgc ctacgagacc ggcggcaagg cctgcaagat gcagtactgc    720

aagcactggg gcgtgcgcct gcccagcggc gtgtggttcg agatggccga caaggacctg    780

ttcgccgccg cccgcttccc cgagtgcccc gagggcagca gcatcagcgc ccccagccag    840

accagcgtgg acgtgagcct gatccaggac gtggagcgca tcctggacta cagcctgtgc    900

caggagacct ggagcaagat ccgcgccggc ctgcccatca gccccgtgga cctgagctac    960

ctggccccca agaaccccgg caccggcccc gccttcacca tcatcaacgg caccctgaag   1020

tacttcgaga cccgctacat ccgcgtggac atcgccgccc ccatcctgag ccgcatggtg   1080

ggcatgatca gcggcaccac caccgagcgc gagctgtggg acgactgggc cccctacgag   1140

gacgtggaga tcggccccaa cggcgtgctg cgcaccagca gcggctacaa gttccccctg   1200

tacatgatcg gccacggcat gctggacagc gacctgcacc tgagcagcaa ggcccaggtg   1260

ttcgagcacc cccacatcca ggacgccgcc agccagctgc ccgacgacga gagcctgttc   1320

ttcggcgaca ccggcctgag caagaacccc atcgagctgg tggagggctg gttcagcagc   1380

tggaagagca gcatcgccag cttcttcttc atcatcggcc tgatcatcgg cctgttcctg   1440

gtgctgcgcg tgggcatcca cctgtgcatc aagctgaagc acaccaagaa gcgccagatc   1500

tacaccgaca tcgagatgaa ccgcctgggc aagtaa                             1536


<210>  4
<211>  1539
<212>  DNA
<213>  Artificial

<220>
<223>  RNA Optimized VSV G protein coding sequence, Indiana serotype

<400>  4
atgaagtgcc tcctgtacct cgccttcctg ttcatcggcg tcaactgcaa gttcacgatc     60

gtcttcccgc acaaccagaa gggcaactgg aagaacgtgc cctcgaacta ccactactgc    120

ccgtcgtcga gcgacctgaa ctggcacaac gacctgatcg gcacggcgct ccaagtcaag    180

atgcccaaga gccacaaggc gatccaggcg gacggctgga tgtgccacgc gtccaaatgg    240

gtcaccacct gcgacttccg ttggtatgga ccgaagtaca tcacgcactc catccggtcc    300

ttcactccct ccgtggagca gtgcaaggag agcatcgagc agacgaagca gggcacgtgg    360

ctgaaccccg ggttcccgcc ccaaagctgc ggctacgcga ctgtgacgga cgccgaggcg    420

gtgatcgtcc aagtgacgcc gcaccacgtg ctggtggacg agtacacggg cgagtgggtg    480

gactcgcagt tcatcaacgg caagtgctcc aactacatct gccccacggt ccacaactcg    540

acgacctggc actcggacta caaggtcaag gggttgtgcg acagcaacct catctccatg    600

gacatcacct tcttctcgga ggacggcgag ctctcgtccc tggggaagga gggcacgggg    660

ttccggagca actacttcgc gtacgagacc ggcgggaagg cctgcaagat gcagtactgc    720

aagcactggg gcgtccggct cccctcgggt gtctggttcg agatggcgga caaggacctc    780

ttcgcggcag cccggttccc ggagtgcccg gaggggtcgt ccatcagcgc tccgtcgcaa    840

acctcggtgg acgtatcgct catccaggac gtcgagagga tcctggacta ctcgttgtgc    900

caagagacct ggagcaagat cagggcgggg ctgccgatct cgccggtgga cctcagctac    960

ctcgcgccga agaacccagg caccggtcct gccttcacca tcatcaatgg caccctcaag   1020

tacttcgaga cccgctacat ccgggtggac atcgccgcgc cgatcctgtc gagaatggtc   1080

ggcatgatca gcgggacgac cacggagcgg gagctgtggg acgactgggc gccctacgag   1140

gacgtggaga tcggacccaa cggcgtcctg aggaccagct ccggctacaa gttccccttg   1200

tacatgatcg gccacggcat gctggactcc gacctccacc tcagctcgaa ggcccaggtg   1260

ttcgagcacc cgcacatcca agacgctgcg tcgcagctgc cggacgacga gtcgctgttc   1320

ttcggcgaca ccgggctatc caagaacccg atcgagctcg tggagggctg gttcagttcg   1380

tggaagagct cgatcgcctc gttcttcttc atcatcgggc tgatcatcgg cctgttcttg   1440

gtgctccgcg tcggcatcca cctgtgcatc aagctgaagc acaccaagaa gaggcagatc   1500

tacacggaca tcgagatgaa ccggctcggg aagtgataa                          1539


<210>  5
<211>  1557
<212>  DNA
<213>  Artificial

<220>
<223>  RNA Optimized VSV G protein coding sequence, New Jersey serotype

<400>  5
atgctctcgt acctcatctt cgcgctcgcc gtctcgccca tcctgggcaa gatcgagatc     60

gtgttcccgc agcacaccac gggggactgg aagcgggttc cccacgagta caactactgc    120

ccgaccagcg cggacaagaa ctcccacggg actcagacag ggatcccggt cgagctgacg    180

atgccgaagg ggctgacgac ccaccaggtt gagggcttca tgtgccactc ggccttgtgg    240

atgaccacgt gcgacttccg gtggtacggg ccgaagtaca tcacccactc catccacaac    300

gaggagccca cggactacca gtgcctggag gccatcaagt cctacaagga cggagtcagc    360

ttcaacccgg ggttcccgcc ccagtcctgc ggctacggca ccgtcaccga cgcggaggcc    420

cacatcgtga cggtcacgcc ccactccgtc aaggtggacg agtacacggg ggagtggatc    480

gacccgcact tcatcggcgg gcgctgcaag ggccagatct gtgagacggt ccacaactcc    540

accaagtggt tcacgtcctc ggacggcgag agcgtctgca gccagctgtt caccctcgtc    600

ggaggcatct tcttctcgga ctcggaggag atcacctcca tggggctccc ggagacgggg    660

atccggagca actacttccc ctacatctcc accgagggga tctgcaagat gccgttctgc    720

cgcaagcagg gctacaagct caagaacgac ctctggttcc agatcatgga cccggacctg    780

gacaagacgg ttcgggacct cccgcacatc aaggactgcg acctctccag ctccatcatc    840

accccgggcg agcacgcgac ggacatctcg ctgatctcag acgtcgagcg gatcctggac    900

tacgcgctct gccagaacac gtggtccaag atcgagtcgg gcgagccgat cacgccggta    960

gacctcagct acctcgggcc gaagaacccg ggggttgggc cggtcttcac catcatcaac   1020

ggctccctgc actacttcac gtcgaagtac ctgcgggtcg agctggagag cccggtcatc   1080

cccaggatgg aggggaaggt tgcgggcact cggatcgtac ggcagctgtg ggaccagtgg   1140

ttccccttcg gggaggtcga gatcggaccc aacggcgtgc tcaagacgaa gcaggggtac   1200

aagttcccgc tacacatcat cggcacgggc gaggtagaca gcgacatcaa gatggagcgg   1260

gttgtcaagc actgggagca cccccacatc gaggccgcgc agaccttcct caagaaggac   1320

gacacaggcg aggtcctcta ctacggcgac accggcgtgt cgaagaaccc cgtcgagctc   1380

gtcgagggct ggttcagcgg ctggcggagc tccctcatgg gcgtgctggc ggtgatcatc   1440

gggttcgtga tcctgatgtt cctcatcaag ctgatcggcg tcctgtcgag cctcttccgg   1500

cccaagcgca ggccgatcta caagtcggac gtggagatgg cgcacttccg gtgataa      1557


<210>  6
<211>  562
<212>  DNA
<213>  Artificial

<220>
<223>  Heat-shock inducible transcriptional control sequence

<400>  6
agatctctgg aacgttcatg aacgttcatg aacgttcatg aagcttcatg aaatttccgg     60

aacgttcgcg atcgcacggg aatattccag tacaatcggg aatattccag gatatccggg    120

aatattccag atcgcccgcc ccgttgacgc aaatgggcgg taggcgtgta cggtgggagg    180

tctatataag cagagctcgt ttagtgaacc gtcagatcac tagaagcttt attgcggtag    240

tttatcacag ttaaattgct aacgcagtca gtgcttctga cacaacagtc tcgaacttaa    300

gctgcagtga ctctcttaag gtagccttgc agaagttggt cgtgaggcac tgggcaggta    360

agtatcaagg ttacaagaca ggtttaagga gaccaataga aactgggctt gtcgagacag    420

agaagactct tgcgtttctg ataggcacct attggtctta ctgacatcca ctttgccttt    480

ctctccacag gtgtccactc ccagttcaat tacagctctt aaggctagag tacttgctag    540

cctcgagtca gcagccacca tg                                             562


<210>  7
<211>  8
<212>  DNA
<213>  Artificial

<220>
<223>  Heat Shock Element


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n is a, c, g, or t

<400>  7
gaannttc                                                               8


<210>  8
<211>  8
<212>  DNA
<213>  Artificial

<220>
<223>  Heat Shock Element

<400>  8
gaacgttc                                                               8


<210>  9
<211>  8
<212>  DNA
<213>  Artificial

<220>
<223>  Heat Shock Element

<400>  9
gaagcttc                                                               8


<210>  10
<211>  8
<212>  DNA
<213>  Artificial

<220>
<223>  Heat Shock Element

<400>  10
gaaatttc                                                               8


<210>  11
<211>  8
<212>  DNA
<213>  Artificial

<220>
<223>  Heat Shock Element

<400>  11
gaatattc                                                               8


<210>  12
<211>  76
<212>  DNA
<213>  Artificial

<220>
<223>  Minimal hCMV promoter

<400>  12
cccgccccgt tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga     60

gctcgtttag tgaacc                                                     76


<210>  13
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Cytoplasmic domain of wild-type VSV G protein

<400>  13

Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg 
1               5                   10                  15      


Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            20                  25                  


