                         SEQUENCE LISTING

<110>  Avila Therapeutics, Inc.
       Niu, Deqiang
       Petter, Russell C.
       Singh, Juswinder
       Kluge, Arthur F.
       Qiao, Lixin
 
<120>  HCV Protease Inhibitors and Uses Thereof

<130>  2007878-0056

<160>  77    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  1

Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Val 
            20  


<210>  2
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  2

Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Val 
            20  


<210>  3
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  3

Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Val 
            20  


<210>  4
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  4

Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Val 
            20  


<210>  5
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  5

Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Val 
            20  


<210>  6
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  6

Gly His Val Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Val 
            20  


<210>  7
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  7

Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Val 
            20  


<210>  8
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  8

Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Val 
            20  


<210>  9
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  9

Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Val 
            20  


<210>  10
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  10

Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Ser Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Ile 
            20  


<210>  11
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  11

Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Ser Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Ile 
            20  


<210>  12
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  12

Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Ser Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Ile 
            20  


<210>  13
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  13

Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys Ala Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Ile 
            20  


<210>  14
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  14

Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys Ala Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Ile 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  15

Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Ser Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Ile 
            20  


<210>  16
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  16

Ala His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Ser Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Ile 
            20  


<210>  17
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  17

Gly His Ala Val Gly Ile Phe Arg Ala Ala Ile Cys Thr Arg Gly Ala 
1               5                   10                  15      


Ala Lys Ser Ile 
            20  


<210>  18
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  18

Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Leu 
            20  


<210>  19
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  19

Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Leu 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  20

Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Leu 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  21

Gly His Val Met Gly Ile Phe Ile Ala Val Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Leu 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  22

Gly His Val Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Leu 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  23

Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Leu 
            20  


<210>  24
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  24

Gly His Ala Ala Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Val 
            20  


<210>  25
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  25

Gly His Ala Ala Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Val 
            20  


<210>  26
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  26

Gly His Ala Ala Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Val 
            20  


<210>  27
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  27

Gly His Ala Ala Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Val 
            20  


<210>  28
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  28

Gly His Ala Ala Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Thr Val 
            20  


<210>  29
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  29

Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Val 
            20  


<210>  30
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  30

Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Val 
            20  


<210>  31
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  31

Gly His Val Val Gly Val Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Leu 
            20  


<210>  32
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  32

Gly His Val Val Gly Val Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Leu 
            20  


<210>  33
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  33

Gly His Val Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Leu 
            20  


<210>  34
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  34

Gly His Val Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Leu 
            20  


<210>  35
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  35

Gly His Val Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Leu 
            20  


<210>  36
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  36

Gly His Val Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Leu 
            20  


<210>  37
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  37

Gly His Val Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Leu 
            20  


<210>  38
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  38

Asp His Val Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Leu 
            20  


<210>  39
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  39

Gly His Val Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Ile 
            20  


<210>  40
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  40

Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Ile 
            20  


<210>  41
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  41

Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Ile 
            20  


<210>  42
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  42

Gly His Val Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Leu 
            20  


<210>  43
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  43

Gly His Val Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Leu 
            20  


<210>  44
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  44

Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Leu 
            20  


<210>  45
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  45

Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Leu 
            20  


<210>  46
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  46

Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Leu 
            20  


<210>  47
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  47

Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Leu 
            20  


<210>  48
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  48

Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Leu 
            20  


<210>  49
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  49

Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Leu 
            20  


<210>  50
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  50

Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Leu 
            20  


<210>  51
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  51

Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Leu 
            20  


<210>  52
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  52

Gly His Ala Val Gly Val Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Leu 
            20  


<210>  53
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  53

Gly His Ala Val Gly Val Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Leu 
            20  


<210>  54
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  54

Gly His Val Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Leu 
            20  


<210>  55
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  55

Gly His Val Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ser Leu 
            20  


<210>  56
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  56

Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Ile 
            20  


<210>  57
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  57

Gly His Val Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Ile 
            20  


<210>  58
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  58

Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Ile 
            20  


<210>  59
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  59

Gly His Val Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Ile 
            20  


<210>  60
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  60

Gly His Val Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Ile 
            20  


<210>  61
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  61

Gly His Val Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Ile 
            20  


<210>  62
<211>  20
<212>  PRT
<213>  Hepatitis C virus

<400>  62

Ser His Cys Val Gly Ile Phe Arg Ala Ala Val Cys Thr Arg Gly Val 
1               5                   10                  15      


Ala Lys Ala Val 
            20  


<210>  63
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic; designed from HCV protease NS3

<400>  63
acgcagaaag cgtctagcca t                                                 21


<210>  64
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic; designed from HCV protease NS3

<400>  64
tactcaccgg ttccgcaga                                                    19


<210>  65
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic; designed from HCV protease NS3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  6-carboxyfluorescein

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Carboxytetramethylrhodamine

<400>  65
cctggaggct gcacgacact cat                                               23


<210>  66
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic; designed from HCV protease NS3

<400>  66
gctgtgggca tctttcggtc tgccgtgtgc acccgaggg                              39


<210>  67
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic; designed from HCV protease NS3

<400>  67
ccctcgggtg cacacggcag accgaaagat gcccacagc                              39


<210>  68
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic; designed from HCV protease NS3

<400>  68
gctgtgggca tctttcggac tgccgtgtgc acccgaggg                              39


<210>  69
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic; designed from HCV protease NS3

<400>  69
ccctcgggtg cacacggcag tccgaaagat gcccacagc                              39


<210>  70
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic; designed from HCV protease NS3

<400>  70
ggggttgcga aggcggtggc ctttgtaccc gtcgagtct                              39


<210>  71
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic; designed from HCV protease NS3

<400>  71
agactcgacg ggtacaaagg ccaccgcctt cgcaacccc                              39


<210>  72
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic; designed from HCV protease NS3

<400>  72
ggggttgcga aggcggtggt ctttgtaccc gtcgagtct                              39


<210>  73
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic; designed from HCV protease NS3

<400>  73
agactcgacg ggtacaaaga ccaccgcctt cgcaacccc                              39


<210>  74
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic; designed from HCV protease NS3

<400>  74
atctttcggg ctgccgtgag cacccgaggg gttgcgaag                              39


<210>  75
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic; designed from HCV protease NS3

<400>  75
cttcgcaacc cctcgggtgc tcacggcagc ccgaaagat                              39


<210>  76
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic; designed from HCV protease NS3

<400>  76
cacgctgtgg gcatctttaa ggctgccgtg tgcacccga                              39


<210>  77
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic; designed from HCV protease NS3

<400>  77
tcgggtgcac acggcagcct taaagatgcc cacagcgtg                              39


