                               SEQUENCE LISTING

<110> PROTEON THERAPEUTICS, INC.
      FRANANO, F. NICHOLAS
      BLAND, KIMBERLY S.      
      WANG, MARCO D.
      DING, BEE C.

<120> RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING 
      AND USE THEREOF

<130> 379893-001WO

<140>
<141>

<150> 60/992,319
<151> 2007-12-04

<160> 118   

<170> PatentIn version 3.5

<210> 1
<211> 240
<212> PRT
<213> Homo sapiens


<220>
<221> VARIANT
<222> (202)..(202)
<223> /replace= "Leu"

<220>
<221> misc_feature
<222> (202)..(202)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 1
Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile 
1               5                   10                  15      


Ser Leu Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Thr Cys Gly Gly 
            20                  25                  30          


Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val Asp 
        35                  40                  45              


Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu Ser Gln 
    50                  55                  60                  


Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val His 
65                  70                  75                  80  


Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu 
                85                  90                  95      


Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu Gly 
            100                 105                 110         


Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr 
        115                 120                 125             


Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr 
    130                 135                 140                 


Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser 
145                 150                 155                 160 


Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala Gly 
                165                 170                 175     


Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu 
            180                 185                 190         


His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr Ser Phe 
        195                 200                 205             


Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val Phe Thr 
    210                 215                 220                 


Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser Asn
225                 230                 235                 240


<210> 2
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide" 


<220>
<221> VARIANT
<222> (201)..(201)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (201)..(201)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 2
Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser 
1               5                   10                  15      


Leu Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Thr Cys Gly Gly Thr 
            20                  25                  30          


Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val Asp Tyr 
        35                  40                  45              


Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu Ser Gln Asn 
    50                  55                  60                  


Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val His Pro 
65                  70                  75                  80  


Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu 
                85                  90                  95      


Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val 
            100                 105                 110         


Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile 
        115                 120                 125             


Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu 
    130                 135                 140                 


Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser 
145                 150                 155                 160 


Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly 
                165                 170                 175     


Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His 
            180                 185                 190         


Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr Ser Phe Val 
        195                 200                 205             


Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln 
    210                 215                 220                 


Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
225                 230                 235         


<210> 3
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide" 


<220>
<221> VARIANT
<222> (200)..(200)
<223> /replace= "Leu"

<220>
<221> misc_feature
<222> (200)..(200)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 3
Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu 
1               5                   10                  15      


Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Thr Cys Gly Gly Thr Leu 
            20                  25                  30          


Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln 
        35                  40                  45              


Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp 
    50                  55                  60                  


Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr 
65                  70                  75                  80  


Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg 
                85                  90                  95      


Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu 
            100                 105                 110         


Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr 
        115                 120                 125             


Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln 
    130                 135                 140                 


Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser 
145                 150                 155                 160 


Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp 
                165                 170                 175     


Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys 
            180                 185                 190         


Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser 
        195                 200                 205             


Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val 
    210                 215                 220                 


Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
225                 230                 235     


<210> 4
<211> 240
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide" 


<220>
<221> VARIANT
<222> (202)..(202)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (202)..(202)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 4
Ala Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile 
1               5                   10                  15      


Ser Leu Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Thr Cys Gly Gly 
            20                  25                  30          


Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val Asp 
        35                  40                  45              


Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu Ser Gln 
    50                  55                  60                  


Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val His 
65                  70                  75                  80  


Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu 
                85                  90                  95      


Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu Gly 
            100                 105                 110         


Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr 
        115                 120                 125             


Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr 
    130                 135                 140                 


Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser 
145                 150                 155                 160 


Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala Gly 
                165                 170                 175     


Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu 
            180                 185                 190         


His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr Ser Phe 
        195                 200                 205             


Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val Phe Thr 
    210                 215                 220                 


Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
225                 230                 235                 240


<210> 5
<211> 186
<212> PRT
<213> Homo sapiens 

<400> 5
Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile 
1               5                   10                  15      


Ser Leu Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Thr Cys Gly Gly 
            20                  25                  30          


Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val Asp 
        35                  40                  45              


Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu Ser Gln 
    50                  55                  60                  


Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val His 
65                  70                  75                  80  


Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu 
                85                  90                  95      


Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu Gly 
            100                 105                 110         


Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr 
        115                 120                 125             


Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr 
    130                 135                 140                 


Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser 
145                 150                 155                 160 


Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala Gly 
                165                 170                 175     


Gly Asp Gly Ser Ser Leu Trp Met Pro Gly 
            180                 185     


<210> 6
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide" 


<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 6
Thr Gln Asp Leu Pro Glu Thr Asn Ala Ala Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Arg Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 7
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide" 


<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 7
Thr Gln Asp Leu Pro Glu Thr Asn Ala Ala Ala Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Arg Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 8
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide" 


<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 8
Thr Gln Asp Leu Pro Glu Thr Ala Ala Ala Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Arg Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 9
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide" 


<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 9
Thr Gln Asp Leu Pro Glu Thr Asn Asn Ala Pro Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Arg Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 10
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide" 


<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 10
Thr Gln Asp Leu Pro Glu Thr Asn Ala Arg Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Arg Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250   


<210> 11
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="Leu" or "Isoleucine" or "Met" or "Lys" or
      "Asp" or "Val"

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="Ala" or "Leu" or "Isoleucine" or "Gly" or
      "Val" or "Thr"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Leu" or "Val" or "Isoleucine" or "Ser" 

<220>
<221> misc_feature
<222> (1)..(3)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 11
Ala Pro Ala 
1           


<210> 12
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="Leu" or "Isoleucine" or "Met" or "Lys" or "Val"

<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Leu" or "Val" or "Isoleucine" or "Ser"

<220>
<221> misc_feature
<222> (3)..(3)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 12
Ala Pro Ala 
1           


<210> 13
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Leu" or "Val" 

<220>
<221> misc_feature
<222> (1)..(3)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 13
Asp Pro Ala 
1           


<210> 14
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Ala Ala Ala 
1           


<210> 15
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 15
Asn Ala Ala 
1           


<210> 16
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Asn Ala Pro 
1           


<210> 17
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 17
Asn Ala Arg 
1           


<210> 18
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
Ala Pro Ala 
1           


<210> 19
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 19
Ala Ala Pro 
1           


<210> 20
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Asn Pro Ala 
1           


<210> 21
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Leu Pro Ala 
1           


<210> 22
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Thr Gln Asp Leu Pro Glu Thr Asn Ala Arg 
1               5                   10  


<210> 23
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Thr Gln Asp Leu Pro Glu Thr Asn Ala Ala 
1               5                   10  


<210> 24
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 24
Thr Asn Ala Arg Val Val Gly Gly 
1               5               


<210> 25
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 25
Thr Ala Ala Ala Val Val Gly Gly 
1               5               


<210> 26
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 26
Thr Asn Ala Ala Ala Val Gly Gly 
1               5               


<210> 27
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 27
Thr Asn Ala Ala Val Val Gly Gly 
1               5               


<210> 28
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Thr Asn Ala Pro Val Val Gly Gly 
1               5               


<210> 29
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 29
Thr Gly Ala Gly Ile Val Gly Gly 
1               5               


<210> 30
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
Thr Val Pro Gly Val Val Gly Gly 
1               5               


<210> 31
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Thr Ala Pro Gly Val Val Gly Gly 
1               5               


<210> 32
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Thr Asn Pro Gly Val Val Gly Gly 
1               5               


<210> 33
<211> 753
<212> DNA
<213> Homo sapiens 

<400> 33
acccaggacc ttccggaaac caatgcccgc gtagtcggag ggactgaggc cgggaggaat       60

tcctggccct ctcagatttc cctccagtac cggtctggag gttcccggta tcacacctgt      120

ggagggaccc ttatcagaca gaactgggtg atgacagctg ctcactgcgt ggattaccag      180

aagactttcc gcgtggtggc tggagaccat aacctgagcc agaatgatgg cactgagcag      240

tacgtgagtg tgcagaagat cgtggtgcat ccatactgga acagcgataa cgtggctgcc      300

ggctatgaca tcgccctgct gcgcctggcc cagagcgtta ccctcaatag ctatgtccag      360

ctgggtgttc tgccccagga gggagccatc ctggctaaca acagtccctg ctacatcaca      420

ggctggggca agaccaagac caatgggcag ctggcccaga ccctgcagca ggcttacctg      480

ccctctgtgg actacgccat ctgctccagc tcctcctact ggggctccac tgtgaagaac      540

accatggtgt gtgctggtgg agatggagtt cgctctggat gccagggtga ctctgggggc      600

cccctccatt gcttggtgaa tggcaagtat tctgtccatg gagtgaccag ctttgtgtcc      660

agccggggct gtaatgtctc caggaagcct acagtcttca cccaggtctc tgcttacatc      720

tcctggataa ataatgtcat cgcctccaac tga                                   753


<210> 34
<211> 24
<212> PRT
<213> Unknown

<220>
<222> source
<223> /note="Description of Unknown: Yeast Sequence"

<400> 34
Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr 
            20                  


<210> 35
<211> 56
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 35
ggctcgagaa aagagaggct gaagctactc aggaccttcc ggaaaccaat gcccgg           56


<210> 36
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 36
gggccgcggc ttatcagttg gaggcgatga cat                                    33


<210> 37
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (204)..(204)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (204)..(204)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 37
Ala Ala Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser 
1               5                   10                  15      


Gln Ile Ser Leu Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Thr Cys 
            20                  25                  30          


Gly Gly Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys 
        35                  40                  45              


Val Asp Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu 
    50                  55                  60                  


Ser Gln Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val 
65                  70                  75                  80  


Val His Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile 
                85                  90                  95      


Ala Leu Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln 
            100                 105                 110         


Leu Gly Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro 
        115                 120                 125             


Cys Tyr Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala 
    130                 135                 140                 


Gln Thr Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys 
145                 150                 155                 160 


Ser Ser Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys 
                165                 170                 175     


Ala Gly Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly 
            180                 185                 190         


Pro Leu His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr 
        195                 200                 205             


Ser Phe Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val 
    210                 215                 220                 


Phe Thr Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala 
225                 230                 235                 240 


Ser Asn



<210> 38
<211> 241
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (203)..(203)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (203)..(203)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 38
Ala Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln 
1               5                   10                  15      


Ile Ser Leu Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Thr Cys Gly 
            20                  25                  30          


Gly Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val 
        35                  40                  45              


Asp Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu Ser 
    50                  55                  60                  


Gln Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val 
65                  70                  75                  80  


His Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala 
                85                  90                  95      


Leu Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu 
            100                 105                 110         


Gly Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys 
        115                 120                 125             


Tyr Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln 
    130                 135                 140                 


Thr Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser 
145                 150                 155                 160 


Ser Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala 
                165                 170                 175     


Gly Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro 
            180                 185                 190         


Leu His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr Ser 
        195                 200                 205             


Phe Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val Phe 
    210                 215                 220                 


Thr Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser 
225                 230                 235                 240


Asn
 


<210> 39
<211> 240
<212> PRT
<213> Unknown

<220>
<222> source
<223> /note="Description of Unknown: Porcine Sequence"

<400> 39
Val Val Gly Gly Thr Glu Ala Gln Arg Asn Ser Trp Pro Ser Gln Ile 
1               5                   10                  15      


Ser Leu Gln Tyr Arg Ser Gly Ser Ser Trp Ala His Thr Cys Gly Gly 
            20                  25                  30          


Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val Asp 
        35                  40                  45              


Arg Glu Leu Thr Phe Arg Val Val Val Gly Glu His Asn Leu Asn Gln 
    50                  55                  60                  


Asn Asp Gly Thr Glu Gln Tyr Val Gly Val Gln Lys Ile Val Val His 
65                  70                  75                  80  


Pro Tyr Trp Asn Thr Asp Asp Val Ala Ala Gly Tyr Asp Ile Ala Leu 
                85                  90                  95      


Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu Gly 
            100                 105                 110         


Val Leu Pro Arg Ala Gly Thr Ile Leu Ala Asn Asn Ser Pro Cys Tyr 
        115                 120                 125             


Ile Thr Gly Trp Gly Leu Thr Arg Thr Asn Gly Gln Leu Ala Gln Thr 
    130                 135                 140                 


Leu Gln Gln Ala Tyr Leu Pro Thr Val Asp Tyr Ala Ile Cys Ser Ser 
145                 150                 155                 160 


Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Ser Met Val Cys Ala Gly 
                165                 170                 175     


Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu 
            180                 185                 190         


His Cys Leu Val Asn Gly Gln Tyr Ala Val His Gly Val Thr Ser Phe 
        195                 200                 205             


Val Ser Arg Leu Gly Cys Asn Val Thr Arg Lys Pro Thr Val Phe Thr 
    210                 215                 220                 


Arg Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
225                 230                 235                 240


<210> 40
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Glu Thr Ala Ala Ala Val Val Gly 
1               5               


<210> 41
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 41
Glu Thr Asn Ala Ala Ala Val Gly 
1               5               


<210> 42
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Glu Thr Asn Ala Ala Val Val Gly 
1               5               


<210> 43
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Glu Thr Asn Ala Pro Val Val Gly 
1               5               


<210> 44
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Glu Thr Gly Ala Gly Ile Val Gly 
1               5               


<210> 45
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 45
Glu Thr Val Pro Gly Val Val Gly 
1               5               


<210> 46
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 46
Glu Thr Ala Pro Gly Val Val Gly 
1               5               


<210> 47
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 47
Glu Thr Asn Pro Gly Val Val Gly 
1               5               


<210> 48
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 48
Glu Thr Asn Pro Ala Val Val Gly 
1               5               


<210> 49
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 49
Glu Thr Asn His Ala Val Val Gly 
1               5               


<210> 50
<211> 90
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 50
Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Leu Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Asn Gly Leu 
    50                  55                  60                  


Leu Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly 
65                  70                  75                  80  


Val Ser Leu Asp Lys Arg Glu Ala Glu Ala 
                85                  90  


<210> 51
<211> 84
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 51
Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Leu Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Asn Gly Leu 
    50                  55                  60                  


Leu Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly 
65                  70                  75                  80  


Val Ser Leu Asp 
                


<210> 52
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 52
Glu Thr Lys Pro Ala Val Val Gly 
1               5               


<210> 53
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 53
Glu Thr His Pro Ala Val Val Gly 
1               5               


<210> 54
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 54
Glu His Asn Pro Ala Val Val Gly 
1               5               


<210> 55
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 55
His Thr Asn Pro Ala Val Val Gly 
1               5               


<210> 56
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 56
Pro Thr His Pro Ala Val Val Gly 
1               5               


<210> 57
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 57
Pro Thr Asn Pro Ala Val Val Gly 
1               5               


<210> 58
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 58
His Thr His Pro Ala Val Val Gly 
1               5               


<210> 59
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 59
Glu Thr Phe Pro Ala Val Val Gly 
1               5               


<210> 60
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 60
His Thr Phe Pro Ala Val Val Gly 
1               5               


<210> 61
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 61
Gly Thr Phe Pro Ala Val Val Gly 
1               5               


<210> 62
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 62
His Thr Gly Pro Ala Val Val Gly 
1               5               


<210> 63
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 63
His Thr Lys Pro Ala Val Val Gly 
1               5               


<210> 64
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 64
Thr Gln Asp Leu Pro Glu Thr Asn Pro Ala Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Arg Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 65
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 65
Thr Gln Asp Leu Pro Glu Thr Asn His Ala Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Arg Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 66
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 66
Thr Gln Asp Leu Pro Glu Thr Lys Pro Ala Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Arg Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 67
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 67
Thr Gln Asp Leu Pro Glu Thr His Pro Ala Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Arg Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250   


<210> 68
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 68
Thr Gln Asp Leu Pro Glu His Asn Pro Ala Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Arg Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 69
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 69
Thr Gln Asp Leu Pro His Thr Asn Pro Ala Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Arg Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 70
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (204)..(204)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (204)..(204)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 70
Ala Arg Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser 
1               5                   10                  15      


Gln Ile Ser Leu Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Thr Cys 
            20                  25                  30          


Gly Gly Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys 
        35                  40                  45              


Val Asp Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu 
    50                  55                  60                  


Ser Gln Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val 
65                  70                  75                  80  


Val His Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile 
                85                  90                  95      


Ala Leu Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln 
            100                 105                 110         


Leu Gly Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro 
        115                 120                 125             


Cys Tyr Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala 
    130                 135                 140                 


Gln Thr Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys 
145                 150                 155                 160 


Ser Ser Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys 
                165                 170                 175     


Ala Gly Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly 
            180                 185                 190         


Pro Leu His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr 
        195                 200                 205             


Ser Phe Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val 
    210                 215                 220                 


Phe Thr Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala 
225                 230                 235                 240 

Ser Asn



<210> 71
<211> 241
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (203)..(203)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (203)..(203)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 71
Arg Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln 
1               5                   10                  15      


Ile Ser Leu Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Thr Cys Gly 
            20                  25                  30          


Gly Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val 
        35                  40                  45              


Asp Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu Ser 
    50                  55                  60                  


Gln Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val 
65                  70                  75                  80  


His Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala 
                85                  90                  95      


Leu Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu 
            100                 105                 110         


Gly Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys 
        115                 120                 125             


Tyr Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln 
    130                 135                 140                 


Thr Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser 
145                 150                 155                 160 


Ser Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala 
                165                 170                 175     


Gly Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro 
            180                 185                 190         


Leu His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr Ser 
        195                 200                 205             


Phe Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val Phe 
    210                 215                 220                 


Thr Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser 
225                 230                 235                 240


Asn



<210> 72
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 72
Thr Gln Asp Leu Pro Glu Thr Asn Pro Ala 
1               5                   10  


<210> 73
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 73
Thr Gln Asp Leu Pro His Thr Asn Pro Ala 
1               5                   10  


<210> 74
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="His" or "Pro" or "Gly" or "Asp" or "Lys" or 
      "Ala"

<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="Ala" or "Pro" or "His"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Leu" or "Isoleucine" or "Met" or "Lys" or "Asp"
      or "Val"

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="Ala" or "Leu" or "Isoleucine" or "Gly" or "Val" 
      or "Thr"

<220>
<221> VARIANT
<222> (5)..(6)
<223> /replace="Leu" or "Val" or "Isoleucine" or "Ser"

<220>
<221> VARIANT
<222> (7)..(7)
<223> /replace="Ala" or "Val"

<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="Thr" or "Phenylalanine" or "Tyr" or "Trp"

<220>
<221> misc_feature
<222> (1)..(8)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 74
Glu Thr Ala Pro Ala Ala Gly Val 
1               5               


<210> 75
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 75
atctacgtag tcggagggac tgaggcc                                           27


<210> 76
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 76
gtcgacaagc ttatcagttg gaggcgat                                          28


<210> 77
<211> 214
<212> PRT
<213> Homo sapiens 

<400> 77
Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile 
1               5                   10                  15      


Ser Leu Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Thr Cys Gly Gly 
            20                  25                  30          


Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val Asp 
        35                  40                  45              


Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu Ser Gln 
    50                  55                  60                  


Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val His 
65                  70                  75                  80  


Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu 
                85                  90                  95      


Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu Gly 
            100                 105                 110         


Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr 
        115                 120                 125             


Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr 
    130                 135                 140                 


Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser 
145                 150                 155                 160 


Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala Gly 
                165                 170                 175     


Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro Pro 
            180                 185                 190         


Pro Leu Leu Gly Glu Trp Gln Val Phe Ser Pro Trp Ser Asp Gln Leu 
        195                 200                 205             


Cys Val Gln Pro Gly Leu 
    210                 


<210> 78
<211> 240
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (26)..(26)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (26)..(26)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (41)..(41)
<223> /replace= "Val" 

<220>
<221> misc_feature
<222> (41)..(41)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (202)..(202)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (202)..(202)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (225)..(225)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (225)..(225)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 78
Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile 
1               5                   10                  15      


Ser Leu Gln Tyr Arg Ser Gly Gly Ser Trp Tyr His Thr Cys Gly Gly 
            20                  25                  30          


Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val Asp 
        35                  40                  45              


Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu Ser Gln 
    50                  55                  60                  


Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val His 
65                  70                  75                  80  


Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu 
                85                  90                  95      


Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu Gly 
            100                 105                 110         


Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr 
        115                 120                 125             


Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr 
    130                 135                 140                 


Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser 
145                 150                 155                 160 


Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala Gly 
                165                 170                 175     


Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu 
            180                 185                 190         


His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr Ser Phe 
        195                 200                 205             


Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val Phe Thr 
    210                 215                 220                 


Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
225                 230                 235                 240


<210> 79
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His"

<220>
<221> misc_feature
<222> (2)..(2)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 79
Thr Gln Asp Leu Pro Glu Thr Asn Ala Arg 
1               5                   10  


<210> 80
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His"

<220>
<221> misc_feature
<222> (2)..(2)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (6)..(6)
<223> /replace="His" or "Pro" or "Gly" or "Asp" or "Lys" or "Ala"

<220>
<221> VARIANT
<222> (7)..(7)
<223> /replace="Ala" or "Pro" or "His"

<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="Leu" or "Isoleucine" or "Met" or "Lys" or "Asp" or 
      "Val"

<220>
<221> VARIANT
<222> (9)..(9)
<223> /replace="Ala" or "Leu" or "Isoleucine" or "Gly" or "Val" or "Thr"

<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="Leu" or "Val" or "Isoleucine" or "Ser"

<220>
<221> misc_feature
<222> (6)..(10)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 80
Thr Glu Asp Leu Pro Glu Thr Ala Pro Ala 
1               5                   10  


<210> 81
<211> 756
<212> DNA
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 81
actcaggacc ttccggaaac caatgcccgg gtagtcggag ggactgaggc cgggaggaac       60

tcctggccct ctcagatttc cctccagtac cggtctggag gttcctggta tcacacctgt      120

ggagggaccc ttatcagaca gaactgggtg atgacagctg cacactgcgt ggattaccag      180

aagactttcc gcgtggtggc tggagaccat aacctgagcc agaatgatgg cactgagcag      240

tacgtgagtg tgcagaagat cgtggtgcat ccatactgga acagcgataa cgtggctgca      300

ggctatgaca tcgccctgct gcgcctggcc cagagcgtta ccctcaatag ctatgtccag      360

ctgggtgttc tgccccagga gggagccatc ctggctaaca acagtccctg ctacatcaca      420

ggctggggca agaccaagac caatgggcag ctggcccaga ccttgcagca ggcttacctg      480

ccctctgtgg actatgccat ctgctccagc tcctcctact ggggctccac tgtgaagaac      540

actatggtgt gtgctggtgg agatggagtt cgctctggat gtcagggtga ctctgggggc      600

cccctccatt gcttggtgaa tggcaagtat tctcttcatg gagtgaccag ctttgtgtcc      660

agccggggct gtaatgtctc tagaaagcct acagtcttca cacgggtctc tgcttacatc      720

tcctggataa ataatgtcat cgcctccaac tgataa                                756


<210> 82
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 82
Thr Gln Asp Leu Pro Glu Thr Asn Ala Arg Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Leu His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Arg Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 83
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His"

<220>
<221> misc_feature
<222> (2)..(2)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (36)..(36)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (51)..(51)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (51)..(51)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (235)..(235)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (235)..(235)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 83
Thr Gln Asp Leu Pro Glu Thr Asn Ala Arg Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 84
<211> 240
<212> PRT
<213> Homo sapiens 


<220>
<221> VARIANT
<222> (26)..(26)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (26)..(26)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (41)..(41)
<223> /replace="Val" 

<220>
<221> misc_feature
<222> (41)..(41)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (202)..(202)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (202)..(202)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (225)..(225)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (225)..(225)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 84
Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile 
1               5                   10                  15      


Ser Leu Gln Tyr Arg Ser Gly Gly Ser Trp Tyr His Thr Cys Gly Gly 
            20                  25                  30          


Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val Asp 
        35                  40                  45              


Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu Ser Gln 
    50                  55                  60                  


Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val His 
65                  70                  75                  80  


Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu 
                85                  90                  95      


Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu Gly 
            100                 105                 110         


Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr 
        115                 120                 125             


Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr 
    130                 135                 140                 


Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser 
145                 150                 155                 160 


Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala Gly 
                165                 170                 175     


Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu 
            180                 185                 190         


His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr Ser Phe 
        195                 200                 205             


Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val Phe Thr 
    210                 215                 220                 


Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
225                 230                 235                 240


<210> 85
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (25)..(25)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (25)..(25)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (40)..(40)
<223> /replace="Val" 

<220>
<221> misc_feature
<222> (40)..(40)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (201)..(201)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (201)..(201)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (224)..(224)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (224)..(224)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 85
Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser 
1               5                   10                  15      


Leu Gln Tyr Arg Ser Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr 
            20                  25                  30          


Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val Asp Tyr 
        35                  40                  45              


Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu Ser Gln Asn 
    50                  55                  60                  


Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val His Pro 
65                  70                  75                  80  


Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu 
                85                  90                  95      


Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val 
            100                 105                 110         


Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile 
        115                 120                 125             


Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu 
    130                 135                 140                 


Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser 
145                 150                 155                 160 


Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly 
                165                 170                 175     


Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His 
            180                 185                 190         


Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr Ser Phe Val 
        195                 200                 205             


Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln 
    210                 215                 220                 


Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
225                 230                 235             


<210> 86
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (24)..(24)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (24)..(24)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (39)..(39)
<223> /replace="Val" 

<220>
<221> misc_feature
<222> (39)..(39)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (200)..(200)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (200)..(200)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (223)..(223)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (223)..(223)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 86
Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu 
1               5                   10                  15      


Gln Tyr Arg Ser Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr Leu 
            20                  25                  30          


Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln 
        35                  40                  45              


Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp 
    50                  55                  60                  


Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr 
65                  70                  75                  80  


Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg 
                85                  90                  95      


Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu 
            100                 105                 110         


Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr 
        115                 120                 125             


Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln 
    130                 135                 140                 


Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser 
145                 150                 155                 160 


Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp 
                165                 170                 175     


Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys 
            180                 185                 190         


Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser 
        195                 200                 205             


Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val 
    210                 215                 220                 


Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
225                 230                 235     


<210> 87
<211> 240
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (26)..(26)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (26)..(26)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (41)..(41)
<223> /replace="Val" 

<220>
<221> misc_feature
<222> (41)..(41)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (202)..(202)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (202)..(202)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (225)..(225)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (225)..(225)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 87
Ala Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile 
1               5                   10                  15      


Ser Leu Gln Tyr Arg Ser Gly Gly Ser Trp Tyr His Thr Cys Gly Gly 
            20                  25                  30          


Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val Asp 
        35                  40                  45              


Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu Ser Gln 
    50                  55                  60                  


Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val His 
65                  70                  75                  80  


Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu 
                85                  90                  95      


Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu Gly 
            100                 105                 110         


Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr 
        115                 120                 125             


Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr 
    130                 135                 140                 


Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser 
145                 150                 155                 160 


Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala Gly 
                165                 170                 175     


Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu 
            180                 185                 190         


His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr Ser Phe 
        195                 200                 205             


Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val Phe Thr 
    210                 215                 220                 


Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
225                 230                 235                 240


<210> 88
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His"

<220>
<221> misc_feature
<222> (2)..(2)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (36)..(36)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (51)..(51)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (51)..(51)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (235)..(235)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (235)..(235)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 88
Thr Gln Asp Leu Pro Glu Thr Asn Ala Ala Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 89
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His" 

<220>
<221> misc_feature
<222> (2)..(2)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (36)..(36)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (51)..(51)
<223> /replace="Val" 

<220>
<221> misc_feature
<222> (51)..(51)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (235)..(235)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (235)..(235)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 89
Thr Gln Asp Leu Pro Glu Thr Asn Ala Ala Ala Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 90
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His" 

<220>
<221> misc_feature
<222> (2)..(2)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (36)..(36)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (51)..(51)
<223> /replace="Val" 

<220>
<221> misc_feature
<222> (51)..(51)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (235)..(235)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (235)..(235)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 90
Thr Gln Asp Leu Pro Glu Thr Ala Ala Ala Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 91
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His" 

<220>
<221> misc_feature
<222> (2)..(2)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (36)..(36)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (51)..(51)
<223> /replace="Val" 

<220>
<221> misc_feature
<222> (51)..(51)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (235)..(235)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (235)..(235)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 91
Thr Gln Asp Leu Pro Glu Thr Asn Asn Ala Pro Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 92
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His" 

<220>
<221> misc_feature
<222> (2)..(2)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (36)..(36)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (51)..(51)
<223> /replace="Val" 

<220>
<221> misc_feature
<222> (51)..(51)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (235)..(235)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (235)..(235)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 92
Thr Gln Asp Leu Pro Glu Thr Asn Ala Arg Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 93
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="Leu" or "Isoleucine" or "Met" or "Lys" or 
      "Asp" or "Val"

<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Leu" or "Val" or "Isoleucine" or "Ser

<220>
<221> misc_feature
<222> (3)..(3)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<400> 93
Ala Pro Ala 
1           


<210> 94
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (28)..(28)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (28)..(28)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (43)..(43)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (43)..(43)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (204)..(204)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (204)..(204)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (227)..(227)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (227)..(227)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 94
Ala Ala Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser 
1               5                   10                  15      


Gln Ile Ser Leu Gln Tyr Arg Ser Gly Gly Ser Trp Tyr His Thr Cys 
            20                  25                  30          


Gly Gly Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys 
        35                  40                  45              


Val Asp Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu 
    50                  55                  60                  


Ser Gln Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val 
65                  70                  75                  80  


Val His Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile 
                85                  90                  95      


Ala Leu Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln 
            100                 105                 110         


Leu Gly Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro 
        115                 120                 125             


Cys Tyr Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala 
    130                 135                 140                 


Gln Thr Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys 
145                 150                 155                 160 


Ser Ser Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys 
                165                 170                 175     


Ala Gly Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly 
            180                 185                 190         


Pro Leu His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr 
        195                 200                 205             


Ser Phe Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val 
    210                 215                 220                 


Phe Thr Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala 
225                 230                 235                 240 


Ser Asn



<210> 95
<211> 241
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (27)..(27)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (27)..(27)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (42)..(42)
<223> /replace="Val" 

<220>
<221> misc_feature
<222> (42)..(42)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (203)..(203)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (203)..(203)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (226)..(226)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (226)..(226)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 95
Ala Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln 
1               5                   10                  15      


Ile Ser Leu Gln Tyr Arg Ser Gly Gly Ser Trp Tyr His Thr Cys Gly 
            20                  25                  30          


Gly Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val 
        35                  40                  45              


Asp Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu Ser 
    50                  55                  60                  


Gln Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val 
65                  70                  75                  80  


His Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala 
                85                  90                  95      


Leu Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu 
            100                 105                 110         


Gly Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys 
        115                 120                 125             


Tyr Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln 
    130                 135                 140                 


Thr Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser 
145                 150                 155                 160 


Ser Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala 
                165                 170                 175     


Gly Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro 
            180                 185                 190         


Leu His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr Ser 
        195                 200                 205             


Phe Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val Phe 
    210                 215                 220                 


Thr Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser 
225                 230                 235                 240


Asn



<210> 96
<211> 89
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 96
Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg Glu Ala Glu Ala 
                85                  


<210> 97
<211> 83
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 97
Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu 
            


<210> 98
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His"

<220>
<221> misc_feature
<222> (2)..(2)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (36)..(36)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (51)..(51)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (51)..(51)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (235)..(235)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (235)..(235)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 98
Thr Gln Asp Leu Pro Glu Thr Asn Pro Ala Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 99
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His" 

<220>
<221> misc_feature
<222> (2)..(2)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (36)..(36)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (51)..(51)
<223> /replace="Val" 

<220>
<221> misc_feature
<222> (51)..(51)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (235)..(235)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (235)..(235)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 99
Thr Gln Asp Leu Pro Glu Thr Asn His Ala Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 100
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His" 

<220>
<221> misc_feature
<222> (2)..(2)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (36)..(36)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (51)..(51)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (51)..(51)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (235)..(235)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (235)..(235)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 100
Thr Gln Asp Leu Pro Glu Thr Lys Pro Ala Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 101
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His" 

<220>
<221> misc_feature
<222> (2)..(2)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (36)..(36)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (51)..(51)
<223> /replace="Val" 

<220>
<221> misc_feature
<222> (51)..(51)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (235)..(235)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (235)..(235)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 101
Thr Gln Asp Leu Pro Glu Thr His Pro Ala Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 102
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His" 

<220>
<221> misc_feature
<222> (2)..(2)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (36)..(36)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (51)..(51)
<223> /replace="Val" 

<220>
<221> misc_feature
<222> (51)..(51)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (235)..(235)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (235)..(235)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 102
Thr Gln Asp Leu Pro Glu His Asn Pro Ala Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250


<210> 103
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="His" 

<220>
<221> misc_feature
<222> (2)..(2)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (36)..(36)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (36)..(36)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (51)..(51)
<223> /replace="Val" 

<220>
<221> misc_feature
<222> (51)..(51)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (212)..(212)
<223> /replace="Leu" 

<220>
<221> misc_feature
<222> (212)..(212)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (235)..(235)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (235)..(235)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 103
Thr Gln Asp Leu Pro His Thr Asn Pro Ala Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
    50                  55                  60                  


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
                85                  90                  95      


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
        115                 120                 125             


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
    130                 135                 140                 


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
    210                 215                 220                 


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
                245                 250



<210> 104
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (28)..(28)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (28)..(28)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (43)..(43)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (43)..(43)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (204)..(204)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (204)..(204)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (227)..(227)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (227)..(227)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 104
Ala Arg Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser 
1               5                   10                  15      


Gln Ile Ser Leu Gln Tyr Arg Ser Gly Gly Ser Trp Tyr His Thr Cys 
            20                  25                  30          


Gly Gly Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys 
        35                  40                  45              


Val Asp Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu 
    50                  55                  60                  


Ser Gln Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val 
65                  70                  75                  80  


Val His Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile 
                85                  90                  95      


Ala Leu Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln 
            100                 105                 110         


Leu Gly Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro 
        115                 120                 125             


Cys Tyr Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala 
    130                 135                 140                 


Gln Thr Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys 
145                 150                 155                 160 


Ser Ser Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys 
                165                 170                 175     


Ala Gly Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly 
            180                 185                 190         


Pro Leu His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr 
        195                 200                 205             


Ser Phe Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val 
    210                 215                 220                 


Phe Thr Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala 
225                 230                 235                 240 


Ser Asn 



<210> 105
<211> 241
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (27)..(27)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (27)..(27)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (42)..(42)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (42)..(42)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (203)..(203)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (203)..(203)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (226)..(226)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (226)..(226)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 105
Arg Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln 
1               5                   10                  15      


Ile Ser Leu Gln Tyr Arg Ser Gly Gly Ser Trp Tyr His Thr Cys Gly 
            20                  25                  30          


Gly Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val 
        35                  40                  45              


Asp Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu Ser 
    50                  55                  60                  


Gln Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val 
65                  70                  75                  80  


His Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala 
                85                  90                  95      


Leu Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu 
            100                 105                 110         


Gly Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys 
        115                 120                 125             


Tyr Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln 
    130                 135                 140                 


Thr Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser 
145                 150                 155                 160 


Ser Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala 
                165                 170                 175     


Gly Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro 
            180                 185                 190         


Leu His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr Ser 
        195                 200                 205             


Phe Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val Phe 
    210                 215                 220                 


Thr Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser 
225                 230                 235                 240


Asn



<210> 106
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (22)..(22)
<223> /replace="Arg"
 
<220>
<221> misc_feature
<222> (22)..(22)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (37)..(37)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (37)..(37)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"
 
<220>
<221> VARIANT
<222> (198)..(198)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (198)..(198)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (221)..(221)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (221)..(221)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 106
Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr 
1               5                   10                  15      


Arg Ser Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr Leu Ile Arg 
            20                  25                  30          


Gln Asn Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr 
        35                  40                  45              


Phe Arg Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr 
    50                  55                  60                  


Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn 
65                  70                  75                  80  


Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala 
                85                  90                  95      


Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln 
            100                 105                 110         


Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp 
        115                 120                 125             


Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala 
    130                 135                 140                 


Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp 
145                 150                 155                 160 


Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val 
                165                 170                 175     


Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val 
            180                 185                 190         


Asn Gly Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg 
        195                 200                 205             


Gly Cys Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala 
    210                 215                 220                 


Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser Asn
225                 230                 235


<210> 107
<211> 234
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (20)..(20)
<223> /replace="Arg"
 
<220>
<221> misc_feature
<222> (20)..(20)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (35)..(35)
<223> /replace="Val"
 
<220>
<221> misc_feature
<222> (35)..(35)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (196)..(196)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (196)..(196)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (219)..(219)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (219)..(219)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 107
Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
1               5                   10                  15      


Gly Gly Ser Trp Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
            20                  25                  30          


Trp Val Met Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg 
        35                  40                  45              


Val Val Ala Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln 
    50                  55                  60                  


Tyr Val Ser Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp 
65                  70                  75                  80  


Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
                85                  90                  95      


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly 
            100                 105                 110         


Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys 
        115                 120                 125             


Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
    130                 135                 140                 


Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
145                 150                 155                 160 


Thr Val Lys Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
                165                 170                 175     


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
            180                 185                 190         


Lys Tyr Ser Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys 
        195                 200                 205             


Asn Val Ser Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile 
    210                 215                 220                 


Ser Trp Ile Asn Asn Val Ile Ala Ser Asn
225                 230         


<210> 108
<211> 231
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (17)..(17)
<223> /replace="Arg"
 
<220>
<221> misc_feature
<222> (17)..(17)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (32)..(32)
<223> /replace="Val"
 
<220>
<221> misc_feature
<222> (32)..(32)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (193)..(193)
<223> /replace="Leu"

<220>
<221> misc_feature
<222> (193)..(193)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (216)..(216)
<223> /replace="Arg" 

<220>
<221> misc_feature
<222> (216)..(216)
<223> /note="Residues given in the sequence have no preference
      with respect to those in the annotations for said positions"

<400> 108
Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser Gly Gly Ser 
1               5                   10                  15      


Trp Tyr His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn Trp Val Met 
            20                  25                  30          


Thr Ala Ala His Cys Val Asp Tyr Gln Lys Thr Phe Arg Val Val Ala 
        35                  40                  45              


Gly Asp His Asn Leu Ser Gln Asn Asp Gly Thr Glu Gln Tyr Val Ser 
    50                  55                  60                  


Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Ser Asp Asn Val Ala 
65                  70                  75                  80  


Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser Val Thr Leu 
                85                  90                  95      


Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Gln Glu Gly Ala Ile Leu 
            100                 105                 110         


Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Lys Thr Lys Thr 
        115                 120                 125             


Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu Pro Ser Val 
    130                 135                 140                 


Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser Thr Val Lys 
145                 150                 155                 160 


Asn Thr Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser Gly Cys Gln 
                165                 170                 175     


Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly Lys Tyr Ser 
            180                 185                 190         


Val His Gly Val Thr Ser Phe Val Ser Ser Arg Gly Cys Asn Val Ser 
        195                 200                 205             


Arg Lys Pro Thr Val Phe Thr Gln Val Ser Ala Tyr Ile Ser Trp Ile 
    210                 215                 220                 


Asn Asn Val Ile Ala Ser Asn
225                 230


<210> 109
<211> 781
<212> DNA
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 109
gaattcagta ctcaggacct tccggaaacc aatgcccggg tagtcggagg gactgaggcc       60

gggaggaact cctggccctc tcagatttcc ctccagtacc ggtctggagg ttcctggtat      120

cacacctgtg gagggaccct tatcagacag aactgggtga tgacagctgc acactgcgtg      180

gattaccaga agactttccg cgtggtggct ggagaccata acctgagcca gaatgatggc      240

actgagcagt acgtgagtgt gcagaagatc gtggtgcatc catactggaa cagcgataac      300

gtggctgcag gctatgacat cgccctgctg cgcctggccc agagcgttac cctcaatagc      360

tatgtccagc tgggtgttct gccccaggag ggagccatcc tggctaacaa cagtccctgc      420

tacatcacag gctggggcaa gaccaagacc aatgggcagc tggcccagac cttgcagcag      480

gcttacctgc cctctgtgga ctatgccatc tgctccagct cctcctactg gggctccact      540

gtgaagaaca ctatggtgtg tgctggtgga gatggagttc gctctggatg tcagggtgac      600

tctgggggcc ccctccattg cttggtgaat ggcaagtatt ctcttcatgg agtgaccagc      660

tttgtgtcca gccggggctg taatgtctct agaaagccta cagtcttcac acgggtctct      720

gcttacatct cctggataaa taatgtcatc gcctccaact gataagcttg gatccgtcga      780

c                                                                      781


<210> 110
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 110
Met Lys Arg Ile Leu Ala Ile His Gln Ala Met Glu Gly Ala Pro Arg 
1               5                   10                  15      


Val Thr Leu Thr Ser Arg Ala Asn Ser Ile Ser Thr Ser Thr His His 
            20                  25                  30          


Ser Val Leu His Ser Gly Ala Pro Val Gly Gly Ala Gly Ala Asp Gly 
        35                  40                  45              


Ile Val His Arg Gly Gln Val Ser Leu Leu Gln Gly Leu Gly Gln Leu 
    50                  55                  60                  


Pro Ile Gly Leu Gly Leu Ala Pro Ala Cys Asp Val Ala Gly Thr Val 
65                  70                  75                  80  


Val Ser Gln Asp Gly Ser Leu Leu Gly Gln Asn Thr Gln Leu Asp Ile 
                85                  90                  95      


Ala Ile Glu Gly Asn Ala Leu Gly Gln Ala Gln Gln Gly Asp Val Ile 
            100                 105                 110         


Ala Cys Ser His Val Ile Ala Val Pro Val Trp Met His His Asp Leu 
        115                 120                 125             


Leu His Thr His Val Leu Leu Ser Ala Ile Ile Leu Ala Gln Val Met 
    130                 135                 140                 


Val Ser Ser His His Ala Glu Ser Leu Leu Val Ile His Ala Val Cys 
145                 150                 155                 160 


Ser Cys His His Pro Val Leu Ser Asp Lys Gly Pro Ser Thr Gly Val 
                165                 170                 175     


Ile Pro Gly Thr Ser Arg Pro Val Leu Glu Gly Asn Leu Arg Gly Pro 
            180                 185                 190         


Gly Val Pro Pro Gly Leu Ser Pro Ser Asp Tyr Pro Gly Ile Gly Phe 
        195                 200                 205             


Arg Lys Val Leu Ser 
    210             


<210> 111
<211> 105
<212> DNA
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 111
actattgcca gcattgctgc taaagaagaa ggggtatctc tcgagaaaag agaggctgaa       60

gctactcagg accttccgga aaccaatgcc cgggtagtcg ggggg                      105


<210> 112
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 112
Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val Ser Leu Glu Lys 
1               5                   10                  15      


Arg Glu Ala Glu Ala Thr Gln Asp Leu Pro Glu Thr Asn Ala Arg Val 
            20                  25                  30          


Val Gly Gly 
        35  


<210> 113
<211> 768
<212> DNA
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 113
ccgcggaccc aggactttcc agaaaccaac gcccgggtag ttggagggac cgaggctcag       60

aggaattctt ggccatctca gatttccctc cagtaccggt ctggaagttc gtgggctcac      120

acctgtggag ggaccctcat caggcagaac tgggtgatga cagccgctca ctgcgtggac      180

agagagttga ccttccgtgt ggtggttgga gagcacaacc tgaaccagaa cgatggcacc      240

gagcagtacg tgggggtgca gaagatcgtg gtgcatccct actggaacac cgacgacgtg      300

gctgcaggct atgacatcgc cctgctgcgc ctggcccaga gtgtaaccct caacagctac      360

gtccagctgg gtgttctgcc aagggctggg accatcctgg ctaacaacag tccctgctac      420

atcacagggt ggggcctgac caggaccaat gggcagctgg cccagaccct gcagcaggct      480

tacctgccca ccgtggacta cgccatctgc tccagctcct cgtactgggg ctccaccgtg      540

aagaacagca tggtgtgcgc cggaggggac ggagttcgct ctggatgtca gggtgattct      600

gggggccccc ttcattgctt ggtgaatggt cagtatgctg tccacggtgt aaccagcttc      660

gtgtcccgcc tgggctgtaa tgtcaccagg aagcccacag tcttcaccag ggtctctgct      720

tacatctctt ggataaataa cgtcattgcc agcaactgat aatctaga                   768


<210> 114
<211> 248
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 114
Thr Gln Asp Phe Pro Glu Thr Asn Ala Arg Val Val Gly Gly Thr Glu 
1               5                   10                  15      


Ala Gln Arg Asn Ser Trp Pro Ser Gln Ile Ser Leu Gln Tyr Arg Ser 
            20                  25                  30          


Gly Ser Ser Trp Ala His Thr Cys Gly Gly Thr Leu Ile Arg Gln Asn 
        35                  40                  45              


Trp Val Met Thr Ala Ala His Cys Val Asp Arg Glu Leu Thr Phe Arg 
    50                  55                  60                  


Val Val Val Gly Glu His Asn Leu Asn Gln Asn Asp Gly Thr Glu Gln 
65                  70                  75                  80  


Tyr Val Gly Val Gln Lys Ile Val Val His Pro Tyr Trp Asn Thr Asp 
                85                  90                  95      


Asp Val Ala Ala Gly Tyr Asp Ile Ala Leu Leu Arg Leu Ala Gln Ser 
            100                 105                 110         


Val Thr Leu Asn Ser Tyr Val Gln Leu Gly Val Leu Pro Arg Ala Gly 
        115                 120                 125             


Thr Ile Leu Ala Asn Asn Ser Pro Cys Tyr Ile Thr Gly Trp Gly Leu 
    130                 135                 140                 


Thr Arg Thr Asn Gly Gln Leu Ala Gln Thr Leu Gln Gln Ala Tyr Leu 
145                 150                 155                 160 


Pro Thr Val Asp Tyr Ala Ile Cys Ser Ser Ser Ser Tyr Trp Gly Ser 
                165                 170                 175     


Thr Val Lys Asn Ser Met Val Cys Ala Gly Gly Asp Gly Val Arg Ser 
            180                 185                 190         


Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu His Cys Leu Val Asn Gly 
        195                 200                 205             


Gln Tyr Ala Val His Gly Val Thr Ser Phe Val Ser Arg Leu Gly Cys 
    210                 215                 220                 


Asn Val Thr Arg Lys Pro Thr Val Phe Thr Arg Val Ser Ala Tyr Ile 
225                 230                 235                 240 


Ser Trp Ile Asn Asn Val Ile Asn 
                245             


<210> 115
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 115
Phe Pro Glu Thr Asn Ala Arg Val Val Gly 
1               5                   10  


<210> 116
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 116
Phe Pro Glu Thr Asn Ala Ala Val Val Gly 
1               5                   10  


<210> 117
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 117
Leu Pro His Thr Asn Pro Ala Val Val Gly 
1               5                   10  


<210> 118
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<222> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 118
Phe Pro Glu Thr Asn His Ala Val Val Gly 
1               5                   10  


