                         SEQUENCE LISTING

<110>  MARFL AB
       Kirsebom, Leif
       Ghosh, Jaydip
       Dasgupta, Santanu
       Larsson, Pontus
 
<120>  New vaccine

<130>  P08108

<150>  SE0702802-0
<151>  2007-12-17

<150>  US61/007,893
<151>  2007-12-17

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  1641
<212>  DNA
<213>  Mycobacterium marinum

<400>  1
gtgaatcgca gggcgttcct ggctcttatg gcggcaactg gcgcggccgg cgcgataaga       60

ggcgcatcgg cgccagcaca cgcgggcggt gacgagcttc gtgaccttcc cgaattctca      120

agcgcaaacg gtgttttgga tacagagttg agcgccgtca ccaatgttgt cgaactcgat      180

ggccgtcaac tgaccttgga gacgttcaac ggccagctac ccgggcccat cctgcgaatc      240

cggccgggtg acaatctgcg ggtcttgctc aagaaccgga ttgtcccggt cgggatcccc      300

accaacaacg tattcatgct gccctattgc gcctccaagt ccaacgacgc gcgttatgac      360

acccggcggg cctgtgtcca cgacctgtgg aacaagtggg agagacggca aacgctcgcg      420

caagaggatg tcgacatcaa cttgcacacc catggcctcc aagtgagccc agaagacccc      480

gcggacaacg tctttctgca gatcggcccg ctaaacgatc accaatacag ctacgacatc      540

ccaaaggatc agccggctgg cttgtattgg taccaccccc atttccacac ggcgaccgca      600

catcagggct ggaacgggct ctccggcgca atcatcgtcg agggcgacat tgacgcggtg      660

cccgagatcg ccgccatgcg tgagcgcacc atcgtgatca acgagctgtg gatcgccgat      720

gacagcggtg aggttccgtt caccgtggtg gcgcccatcg cgggcgatgt gccgttcgcc      780

tcctttccct cagtgccgtc gagcatgtac tacaccgtca acggccaact catcccagac      840

atcaccatgc aaccgggtga agcccagcgc tttcgggtgc tcaacgcgtg cccgcatcgg      900

tcgatatggc tgcacgtgga agggcattca ctcgagcaga tcggaaccga tgggacgccc      960

tacgccgccc cgcgcacgcg ccagcacatt ttcttggcct cggccaaccg ggccgagttc     1020

atcatcaaag cgggcgagcc cgggcgctac cggatctacg ccgaagccta cgaccaggga     1080

caccccggtg gcccccgccc ttatctgccg ctggccaccc tggtggtgcg cggcaaaccg     1140

accgacacac cgatgccgaa gaccctggtg gagccgccac ggatgccgaa cctgccggtg     1200

tcgcggcgcc gggttctggt gttctccggc gatatcagcg ggcggaccgg tatgggaatc     1260

cagttcctca tcgacggtaa ggagatgaat atggaccgga ttgatcagga ggtcgagggt     1320

ggcacggtcg aggagtggac gatagtcaat gaggacgtct tccagcaccc cttgcatatc     1380

cacataaacc cgttccaggt tgtcgacgtc caagggatcc cagcaggtga caccagttgg     1440

gcggcggcct acgagcccga catctggtgg gacacattcc gcctaccgcc gtacggcagg     1500

tatacgttgc ggacctactt ccgtccggac gtgaccggca agaccgtcta tcactgtcac     1560

atcctgcccc acgaagacag gggaatgatg ggcatcttgc tcgtcgatcc cccagggcag     1620

tatccgaagg gggcgccgtg a                                               1641


<210>  2
<211>  546
<212>  PRT
<213>  Mycobacterium marinum

<400>  2

Val Asn Arg Arg Ala Phe Leu Ala Leu Met Ala Ala Thr Gly Ala Ala 
1               5                   10                  15      


Gly Ala Ile Arg Gly Ala Ser Ala Pro Ala His Ala Gly Gly Asp Glu 
            20                  25                  30          


Leu Arg Asp Leu Pro Glu Phe Ser Ser Ala Asn Gly Val Leu Asp Thr 
        35                  40                  45              


Glu Leu Ser Ala Val Thr Asn Val Val Glu Leu Asp Gly Arg Gln Leu 
    50                  55                  60                  


Thr Leu Glu Thr Phe Asn Gly Gln Leu Pro Gly Pro Ile Leu Arg Ile 
65                  70                  75                  80  


Arg Pro Gly Asp Asn Leu Arg Val Leu Leu Lys Asn Arg Ile Val Pro 
                85                  90                  95      


Val Gly Ile Pro Thr Asn Asn Val Phe Met Leu Pro Tyr Cys Ala Ser 
            100                 105                 110         


Lys Ser Asn Asp Ala Arg Tyr Asp Thr Arg Arg Ala Cys Val His Asp 
        115                 120                 125             


Leu Trp Asn Lys Trp Glu Arg Arg Gln Thr Leu Ala Gln Glu Asp Val 
    130                 135                 140                 


Asp Ile Asn Leu His Thr His Gly Leu Gln Val Ser Pro Glu Asp Pro 
145                 150                 155                 160 


Ala Asp Asn Val Phe Leu Gln Ile Gly Pro Leu Asn Asp His Gln Tyr 
                165                 170                 175     


Ser Tyr Asp Ile Pro Lys Asp Gln Pro Ala Gly Leu Tyr Trp Tyr His 
            180                 185                 190         


Pro His Phe His Thr Ala Thr Ala His Gln Gly Trp Asn Gly Leu Ser 
        195                 200                 205             


Gly Ala Ile Ile Val Glu Gly Asp Ile Asp Ala Val Pro Glu Ile Ala 
    210                 215                 220                 


Ala Met Arg Glu Arg Thr Ile Val Ile Asn Glu Leu Trp Ile Ala Asp 
225                 230                 235                 240 


Asp Ser Gly Glu Val Pro Phe Thr Val Val Ala Pro Ile Ala Gly Asp 
                245                 250                 255     


Val Pro Phe Ala Ser Phe Pro Ser Val Pro Ser Ser Met Tyr Tyr Thr 
            260                 265                 270         


Val Asn Gly Gln Leu Ile Pro Asp Ile Thr Met Gln Pro Gly Glu Ala 
        275                 280                 285             


Gln Arg Phe Arg Val Leu Asn Ala Cys Pro His Arg Ser Ile Trp Leu 
    290                 295                 300                 


His Val Glu Gly His Ser Leu Glu Gln Ile Gly Thr Asp Gly Thr Pro 
305                 310                 315                 320 


Tyr Ala Ala Pro Arg Thr Arg Gln His Ile Phe Leu Ala Ser Ala Asn 
                325                 330                 335     


Arg Ala Glu Phe Ile Ile Lys Ala Gly Glu Pro Gly Arg Tyr Arg Ile 
            340                 345                 350         


Tyr Ala Glu Ala Tyr Asp Gln Gly His Pro Gly Gly Pro Arg Pro Tyr 
        355                 360                 365             


Leu Pro Leu Ala Thr Leu Val Val Arg Gly Lys Pro Thr Asp Thr Pro 
    370                 375                 380                 


Met Pro Lys Thr Leu Val Glu Pro Pro Arg Met Pro Asn Leu Pro Val 
385                 390                 395                 400 


Ser Arg Arg Arg Val Leu Val Phe Ser Gly Asp Ile Ser Gly Arg Thr 
                405                 410                 415     


Gly Met Gly Ile Gln Phe Leu Ile Asp Gly Lys Glu Met Asn Met Asp 
            420                 425                 430         


Arg Ile Asp Gln Glu Val Glu Gly Gly Thr Val Glu Glu Trp Thr Ile 
        435                 440                 445             


Val Asn Glu Asp Val Phe Gln His Pro Leu His Ile His Ile Asn Pro 
    450                 455                 460                 


Phe Gln Val Val Asp Val Gln Gly Ile Pro Ala Gly Asp Thr Ser Trp 
465                 470                 475                 480 


Ala Ala Ala Tyr Glu Pro Asp Ile Trp Trp Asp Thr Phe Arg Leu Pro 
                485                 490                 495     


Pro Tyr Gly Arg Tyr Thr Leu Arg Thr Tyr Phe Arg Pro Asp Val Thr 
            500                 505                 510         


Gly Lys Thr Val Tyr His Cys His Ile Leu Pro His Glu Asp Arg Gly 
        515                 520                 525             


Met Met Gly Ile Leu Leu Val Asp Pro Pro Gly Gln Tyr Pro Lys Gly 
    530                 535                 540                 


Ala Pro 
545     


<210>  3
<211>  204
<212>  DNA
<213>  Mycobacterium marinum

<400>  3
atgtccgatg agcacaccca ccacgggccg catgcgcacg aacaccggca cggcgaggtg       60

acccacagcc acgcccacac cacccatcag cacgaacacg tcgagcacgc acacccgcac      120

tcacacgatg acgggaccga gcacacccat cagcacgtgc atgaatcggg cctggaaagc      180

gtgcacagcc acgcgcacag ctga                                             204


<210>  4
<211>  67
<212>  PRT
<213>  Mycobacterium marinum

<400>  4

Met Ser Asp Glu His Thr His His Gly Pro His Ala His Glu His Arg 
1               5                   10                  15      


His Gly Glu Val Thr His Ser His Ala His Thr Thr His Gln His Glu 
            20                  25                  30          


His Val Glu His Ala His Pro His Ser His Asp Asp Gly Thr Glu His 
        35                  40                  45              


Thr His Gln His Val His Glu Ser Gly Leu Glu Ser Val His Ser His 
    50                  55                  60                  


Ala His Ser 
65          


<210>  5
<211>  669
<212>  DNA
<213>  Mycobacterium marinum

<400>  5
atgacagcac ccggcggctc cttcgacgag ggtgcccacg acggcgctgc ctcaccccca       60

cccggtgagc agccttccga acaacccttt tccccaccgc ccgacgcccc ctgggctgcc      120

ccggaagcgg catcaccagc cgacgactac ccagcgccgt cctatccgcc gcccgcctac      180

ccgccggagc cggtcggacc gggcggatac ccacccgact acgcgaccgg gtacccaccc      240

ccgcccggct acccaccgcc cgggtacccg ccctacggcg cagccgcggg cgagtacggg      300

ggcaccccgt accctccgcc cccgccgccc cccgcgccca tggcggcacc ttacggcgcg      360

ccgccaccca actacccgcc gccgtcctac cccggcgggt actacccgcc accggatccg      420

atggcgggtt atggaccggc gctgcccggc atgaacacca tggcgatcgt cgcgctggtg      480

tcctcgttgg tcggtgtgtt ctgctgcatc ggctcggtcg tggcgatcgt ggtcggcacc      540

atcgcaatca accagatcaa gcaaacccgc gaagatggct acggcctggc ggtggccggc      600

atcgtgatcg cggtcgcgac gctgttgatc tacctggtag tcggaatctt cagcattccc      660

tctcactag                                                              669


<210>  6
<211>  222
<212>  PRT
<213>  Mycobacterium marinum

<400>  6

Met Thr Ala Pro Gly Gly Ser Phe Asp Glu Gly Ala His Asp Gly Ala 
1               5                   10                  15      


Ala Ser Pro Pro Pro Gly Glu Gln Pro Ser Glu Gln Pro Phe Ser Pro 
            20                  25                  30          


Pro Pro Asp Ala Pro Trp Ala Ala Pro Glu Ala Ala Ser Pro Ala Asp 
        35                  40                  45              


Asp Tyr Pro Ala Pro Ser Tyr Pro Pro Pro Ala Tyr Pro Pro Glu Pro 
    50                  55                  60                  


Val Gly Pro Gly Gly Tyr Pro Pro Asp Tyr Ala Thr Gly Tyr Pro Pro 
65                  70                  75                  80  


Pro Pro Gly Tyr Pro Pro Pro Gly Tyr Pro Pro Tyr Gly Ala Ala Ala 
                85                  90                  95      


Gly Glu Tyr Gly Gly Thr Pro Tyr Pro Pro Pro Pro Pro Pro Pro Ala 
            100                 105                 110         


Pro Met Ala Ala Pro Tyr Gly Ala Pro Pro Pro Asn Tyr Pro Pro Pro 
        115                 120                 125             


Ser Tyr Pro Gly Gly Tyr Tyr Pro Pro Pro Asp Pro Met Ala Gly Tyr 
    130                 135                 140                 


Gly Pro Ala Leu Pro Gly Met Asn Thr Met Ala Ile Val Ala Leu Val 
145                 150                 155                 160 


Ser Ser Leu Val Gly Val Phe Cys Cys Ile Gly Ser Val Val Ala Ile 
                165                 170                 175     


Val Val Gly Thr Ile Ala Ile Asn Gln Ile Lys Gln Thr Arg Glu Asp 
            180                 185                 190         


Gly Tyr Gly Leu Ala Val Ala Gly Ile Val Ile Ala Val Ala Thr Leu 
        195                 200                 205             


Leu Ile Tyr Leu Val Val Gly Ile Phe Ser Ile Pro Ser His 
    210                 215                 220         


<210>  7
<211>  1164
<212>  DNA
<213>  Mycobacterium marinum

<400>  7
atgcgggtgg cgatgttgac tcgggagtac ccaccggagg tctatggcgg agctggggta       60

catgtcaccg agctggtggc tcgattacag cgcctgtgca ccgtcgacgt gcattgcatg      120

ggcgcacccc gccccgacgc gtcggcccat cagcccgatc cgcggctggc gaacgccaac      180

ccggcactgg ccacattgtc cgcggatctg gtgatagcca atgccgccga cgcagccagc      240

gtggtgcact cacatacctg gtacaccggc ctggcggggc atctggccgc cctgctctac      300

ggcattccgc acgtcttgac cgcccactcg ctcgaaccga tgcggccctg gaaaaccgag      360

cagctcggcg gcggctatca gatctcgtcc tgggtggaga agaccgccgt cctggccgcc      420

gacgcggtaa tcgcggtcag ctccggaatg cgtgatgacg tcctgcgcct gtaccccggg      480

ctggatccag ggatggtgca tgtcgtccgc aacggcatcg acaccgaagt gtggtttccg      540

gccggaccgg ttggtaccgc ttcggtgctc gccgaactcg gggtcgaccc gaaccgcccc      600

attgtggcgt tcgtcgggcg gatcacccgg caaaagggcg taccgcactt gctggcagcg      660

gcacaccagt tcagcccgga cgtccagttg gtgctgtgcg cgggtgctcc cgacaccccg      720

gaaatcgcca atgaagtgca gtccgcggtg gctcaactgg ccagcactcg tagcggggtg      780

ttctggatcc gcgacatcct gcccgtgcag aagcttcgcg aaatactttc ggccgcaaca      840

gtttttgttt gcgcatcgat atacgagcca ttgggcatcg tgaacctcga agcaatggcc      900

tgcgcgaccg cggtggtggc ctccgatgtc ggcggcatcc ccgaggtggt cgccgacgga      960

atcaccggca cgctggtgca ttacgcggcc gacgaccccg ccggttatca atccaggctg     1020

gcacaggcgg taaatgcact ggtcgcggac ccagccaaag ccgaacgcta cggccaagcc     1080

ggacggcagc gttgtatcga ggaattctcc tggacacaga ttgccgagca gacgctggat     1140

atctatcgaa aagtgtgccg atag                                            1164


<210>  8
<211>  387
<212>  PRT
<213>  Mycobacterium marinum

<400>  8

Met Arg Val Ala Met Leu Thr Arg Glu Tyr Pro Pro Glu Val Tyr Gly 
1               5                   10                  15      


Gly Ala Gly Val His Val Thr Glu Leu Val Ala Arg Leu Gln Arg Leu 
            20                  25                  30          


Cys Thr Val Asp Val His Cys Met Gly Ala Pro Arg Pro Asp Ala Ser 
        35                  40                  45              


Ala His Gln Pro Asp Pro Arg Leu Ala Asn Ala Asn Pro Ala Leu Ala 
    50                  55                  60                  


Thr Leu Ser Ala Asp Leu Val Ile Ala Asn Ala Ala Asp Ala Ala Ser 
65                  70                  75                  80  


Val Val His Ser His Thr Trp Tyr Thr Gly Leu Ala Gly His Leu Ala 
                85                  90                  95      


Ala Leu Leu Tyr Gly Ile Pro His Val Leu Thr Ala His Ser Leu Glu 
            100                 105                 110         


Pro Met Arg Pro Trp Lys Thr Glu Gln Leu Gly Gly Gly Tyr Gln Ile 
        115                 120                 125             


Ser Ser Trp Val Glu Lys Thr Ala Val Leu Ala Ala Asp Ala Val Ile 
    130                 135                 140                 


Ala Val Ser Ser Gly Met Arg Asp Asp Val Leu Arg Leu Tyr Pro Gly 
145                 150                 155                 160 


Leu Asp Pro Gly Met Val His Val Val Arg Asn Gly Ile Asp Thr Glu 
                165                 170                 175     


Val Trp Phe Pro Ala Gly Pro Val Gly Thr Ala Ser Val Leu Ala Glu 
            180                 185                 190         


Leu Gly Val Asp Pro Asn Arg Pro Ile Val Ala Phe Val Gly Arg Ile 
        195                 200                 205             


Thr Arg Gln Lys Gly Val Pro His Leu Leu Ala Ala Ala His Gln Phe 
    210                 215                 220                 


Ser Pro Asp Val Gln Leu Val Leu Cys Ala Gly Ala Pro Asp Thr Pro 
225                 230                 235                 240 


Glu Ile Ala Asn Glu Val Gln Ser Ala Val Ala Gln Leu Ala Ser Thr 
                245                 250                 255     


Arg Ser Gly Val Phe Trp Ile Arg Asp Ile Leu Pro Val Gln Lys Leu 
            260                 265                 270         


Arg Glu Ile Leu Ser Ala Ala Thr Val Phe Val Cys Ala Ser Ile Tyr 
        275                 280                 285             


Glu Pro Leu Gly Ile Val Asn Leu Glu Ala Met Ala Cys Ala Thr Ala 
    290                 295                 300                 


Val Val Ala Ser Asp Val Gly Gly Ile Pro Glu Val Val Ala Asp Gly 
305                 310                 315                 320 


Ile Thr Gly Thr Leu Val His Tyr Ala Ala Asp Asp Pro Ala Gly Tyr 
                325                 330                 335     


Gln Ser Arg Leu Ala Gln Ala Val Asn Ala Leu Val Ala Asp Pro Ala 
            340                 345                 350         


Lys Ala Glu Arg Tyr Gly Gln Ala Gly Arg Gln Arg Cys Ile Glu Glu 
        355                 360                 365             


Phe Ser Trp Thr Gln Ile Ala Glu Gln Thr Leu Asp Ile Tyr Arg Lys 
    370                 375                 380                 


Val Cys Arg 
385         


<210>  9
<211>  755
<212>  DNA
<213>  Mycobacterium marinum

<400>  9
atgagcggcc attccaagtg ggccaccacc aagcacaaga aggccgtcat cacgcccgcc       60

gcggcaagat gttcgcacgg ctgatcaaga acatcgaggt cgcggctcgc gtcggtggcg      120

gtgacccggc gggaaacccc accctctacg acgccatcca aaaggccaag aaaagctcgg      180

tgcccaacga gaacatcgag cgggcccgca agcgcggtgc cggtgaagag gccggtgggg      240

cggactggca gaccatcatg tacgagggtt acgcgcccaa cggtgtggcc gtactgatcg      300

agtgtctgac cgacaaccgc aaccgcgctg ccagcgaggt gcgggtggcg atgacgcgca      360

atggcggcgc catggctgat ccggggtcgg tgtcctacct gttttcccgc aagggcgtgg      420

tgaccctgga gaagaacggt ctgaccgaag acgacgtgct ggcggccgtg ttggaagccg      480

gcgccgagga cgtcaacgac ctcggggaca gcttcgaggt gatctccgaa ccgggtgaac      540

tggtcgcggt acgctccgcg ctgcaggatg ccggcatcga ctacgaatcg gccgaggcgg      600

gctttcagtc gtcggtgacc gtgccggtgg acgtcgacgg ggcccgcaag gttttcaagc      660

tcgtcgacgc gctggaagaa agcgacgacg ttcagaacgt gtggaccaac gtggacgtgt      720

ccgatgaggt gctggcggag ctcgacgagg agtag                                 755


<210>  10
<211>  251
<212>  PRT
<213>  Mycobacterium marinum

<400>  10

Met Ser Gly His Ser Lys Trp Ala Thr Thr Lys His Lys Lys Ala Val 
1               5                   10                  15      


Ile Asp Ala Arg Arg Gly Lys Met Phe Ala Arg Leu Ile Lys Asn Ile 
            20                  25                  30          


Glu Val Ala Ala Arg Val Gly Gly Gly Asp Pro Ala Gly Asn Pro Thr 
        35                  40                  45              


Leu Tyr Asp Ala Ile Gln Lys Ala Lys Lys Ser Ser Val Pro Asn Glu 
    50                  55                  60                  


Asn Ile Glu Arg Ala Arg Lys Arg Gly Ala Gly Glu Glu Ala Gly Gly 
65                  70                  75                  80  


Ala Asp Trp Gln Thr Ile Met Tyr Glu Gly Tyr Ala Pro Asn Gly Val 
                85                  90                  95      


Ala Val Leu Ile Glu Cys Leu Thr Asp Asn Arg Asn Arg Ala Ala Ser 
            100                 105                 110         


Glu Val Arg Val Ala Met Thr Arg Asn Gly Gly Ala Met Ala Asp Pro 
        115                 120                 125             


Gly Ser Val Ser Tyr Leu Phe Ser Arg Lys Gly Val Val Thr Leu Glu 
    130                 135                 140                 


Lys Asn Gly Leu Thr Glu Asp Asp Val Leu Ala Ala Val Leu Glu Ala 
145                 150                 155                 160 


Gly Ala Glu Asp Val Asn Asp Leu Gly Asp Ser Phe Glu Val Ile Ser 
                165                 170                 175     


Glu Pro Gly Glu Leu Val Ala Val Arg Ser Ala Leu Gln Asp Ala Gly 
            180                 185                 190         


Ile Asp Tyr Glu Ser Ala Glu Ala Gly Phe Gln Ser Ser Val Thr Val 
        195                 200                 205             


Pro Val Asp Val Asp Gly Ala Arg Lys Val Phe Lys Leu Val Asp Ala 
    210                 215                 220                 


Leu Glu Glu Ser Asp Asp Val Gln Asn Val Trp Thr Asn Val Asp Val 
225                 230                 235                 240 


Ser Asp Glu Val Leu Ala Glu Leu Asp Glu Glu 
                245                 250     


<210>  11
<211>  402
<212>  DNA
<213>  Mycobacterium marinum

<400>  11
atgctgatca ttgccctcgt tttagccctc attgggctcg ttgcgctggt gttcgcggtg       60

gtcaccagca atcagctggt ggcgtgggtg tgcatcggcg ccagtgcact gggtgtggtc      120

ttgctgatcg ttgacgccct cagggagcgt cagcaacgtg aggcggccag caaagaccag      180

gatgaggccg aacaaccagc cgatgccgac ggcgaggccg actacgtcga ataccctgac      240

gatgacgccg aggcggaacc ggccgccgaa gatgtcgagg acgccgaaga gggctccgag      300

gacaccgagg gcccagagga caccgagggc caagaggacg ccgatactgc ggaagaatcg      360

acggtgtccg ccgacgctaa gcgtgacgac agcgccgaat ag                         402


<210>  12
<211>  133
<212>  PRT
<213>  Mycobacterium marinum

<400>  12

Met Leu Ile Ile Ala Leu Val Leu Ala Leu Ile Gly Leu Val Ala Leu 
1               5                   10                  15      


Val Phe Ala Val Val Thr Ser Asn Gln Leu Val Ala Trp Val Cys Ile 
            20                  25                  30          


Gly Ala Ser Ala Leu Gly Val Val Leu Leu Ile Val Asp Ala Leu Arg 
        35                  40                  45              


Glu Arg Gln Gln Arg Glu Ala Ala Ser Lys Asp Gln Asp Glu Ala Glu 
    50                  55                  60                  


Gln Pro Ala Asp Ala Asp Gly Glu Ala Asp Tyr Val Glu Tyr Pro Asp 
65                  70                  75                  80  


Asp Asp Ala Glu Ala Glu Pro Ala Ala Glu Asp Val Glu Asp Ala Glu 
                85                  90                  95      


Glu Gly Ser Glu Asp Thr Glu Gly Pro Glu Asp Thr Glu Gly Gln Glu 
            100                 105                 110         


Asp Ala Asp Thr Ala Glu Glu Ser Thr Val Ser Ala Asp Ala Lys Arg 
        115                 120                 125             


Asp Asp Ser Ala Glu 
    130             


<210>  13
<211>  669
<212>  DNA
<213>  Mycobacterium marinum

<400>  13
atgacagcac ccggcggctc cttcgacgag ggtgcccacg acggcgctgc ctcaccccca       60

cccggtgagc agccttccga acaacccttt tccccaccgc ccgacgcccc ctgggctgcc      120

ccggaagcgg catcaccagc cgacgactac ccagcgccgt cctatccgcc gcccgcctac      180

ccgccggagc cggtcggacc gggcggatac ccacccgact acgcgaccgg gtacccaccc      240

ccgcccggct acccaccgcc cgggtacccg ccctacggcg cagccgcggg cgagtacggg      300

ggcaccccgt accctccgcc cccgccgccc cccgcgccca tggcggcacc ttacggcgcg      360

ccgccaccca actacccgcc gccgtcctac cccggcgggt actacccgcc accggatccg      420

atggcgggtt atggaccggc gctgcccggc atgaacacca tggcgatcgt cgcgctggtg      480

tcctcgttgg tcggtgtgtt ctgctgcatc ggctcggtcg tggcgatcgt ggtcggcacc      540

atcgcaatca accagatcaa gcaaacccgc gaagatggct acggcctggc ggtggccggc      600

atcgtgatcg cggtcgcgac gctgttgatc tacctggtag tcggaatctt cagcattccc      660

tctcactag                                                              669


<210>  14
<211>  222
<212>  PRT
<213>  Mycobacterium marinum

<400>  14

Met Thr Ala Pro Gly Gly Ser Phe Asp Glu Gly Ala His Asp Gly Ala 
1               5                   10                  15      


Ala Ser Pro Pro Pro Gly Glu Gln Pro Ser Glu Gln Pro Phe Ser Pro 
            20                  25                  30          


Pro Pro Asp Ala Pro Trp Ala Ala Pro Glu Ala Ala Ser Pro Ala Asp 
        35                  40                  45              


Asp Tyr Pro Ala Pro Ser Tyr Pro Pro Pro Ala Tyr Pro Pro Glu Pro 
    50                  55                  60                  


Val Gly Pro Gly Gly Tyr Pro Pro Asp Tyr Ala Thr Gly Tyr Pro Pro 
65                  70                  75                  80  


Pro Pro Gly Tyr Pro Pro Pro Gly Tyr Pro Pro Tyr Gly Ala Ala Ala 
                85                  90                  95      


Gly Glu Tyr Gly Gly Thr Pro Tyr Pro Pro Pro Pro Pro Pro Pro Ala 
            100                 105                 110         


Pro Met Ala Ala Pro Tyr Gly Ala Pro Pro Pro Asn Tyr Pro Pro Pro 
        115                 120                 125             


Ser Tyr Pro Gly Gly Tyr Tyr Pro Pro Pro Asp Pro Met Ala Gly Tyr 
    130                 135                 140                 


Gly Pro Ala Leu Pro Gly Met Asn Thr Met Ala Ile Val Ala Leu Val 
145                 150                 155                 160 


Ser Ser Leu Val Gly Val Phe Cys Cys Ile Gly Ser Val Val Ala Ile 
                165                 170                 175     


Val Val Gly Thr Ile Ala Ile Asn Gln Ile Lys Gln Thr Arg Glu Asp 
            180                 185                 190         


Gly Tyr Gly Leu Ala Val Ala Gly Ile Val Ile Ala Val Ala Thr Leu 
        195                 200                 205             


Leu Ile Tyr Leu Val Val Gly Ile Phe Ser Ile Pro Ser His 
    210                 215                 220         


<210>  15
<211>  606
<212>  DNA
<213>  Mycobacterium tuberculosis

<400>  15
ttgatcacca tgacggctcc cagcggctcc tctggcgaga gtgcgcacga cgccgcgggt       60

ggaccgcctc cggtcggtga gcggcccccc gaacagccca ttgctgacgc tccttgggcg      120

ccgccggcat cttcgccgat ggccaaccac ccgcccccgg cgtatccgcc gtccggttac      180

ccgcctgctt accagcccgg gtatccgacc ggctatccac cgccgatgcc acccgggggc      240

tatgcgccgc ccggatatcc accccccggc acttcttcag caggctacgg cgacatacca      300

tacccgccca tgcctccgcc atacggtgga tctccgggcg gctactaccc ggagccgggc      360

tacctagacg gctacggccc atcgcagccc ggcatgaaca ccatggcgct cgtctcactg      420

atctcggcgc tcgtcggtgt gctttgctgc atcggctcga tcgtgggcat cgtgttcggc      480

gcgatcgcca tcaaccagat caagcagaca cgcgaagaag gctacggcct ggcggtggcc      540

ggcattgtga ttggcatcgc gaccctgctg gtctacatga tcgcggggat cttcgctatc      600

ccttag                                                                 606


<210>  16
<211>  201
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  16

Leu Ile Thr Met Thr Ala Pro Ser Gly Ser Ser Gly Glu Ser Ala His 
1               5                   10                  15      


Asp Ala Ala Gly Gly Pro Pro Pro Val Gly Glu Arg Pro Pro Glu Gln 
            20                  25                  30          


Pro Ile Ala Asp Ala Pro Trp Ala Pro Pro Ala Ser Ser Pro Met Ala 
        35                  40                  45              


Asn His Pro Pro Pro Ala Tyr Pro Pro Ser Gly Tyr Pro Pro Ala Tyr 
    50                  55                  60                  


Gln Pro Gly Tyr Pro Thr Gly Tyr Pro Pro Pro Met Pro Pro Gly Gly 
65                  70                  75                  80  


Tyr Ala Pro Pro Gly Tyr Pro Pro Pro Gly Thr Ser Ser Ala Gly Tyr 
                85                  90                  95      


Gly Asp Ile Pro Tyr Pro Pro Met Pro Pro Pro Tyr Gly Gly Ser Pro 
            100                 105                 110         


Gly Gly Tyr Tyr Pro Glu Pro Gly Tyr Leu Asp Gly Tyr Gly Pro Ser 
        115                 120                 125             


Gln Pro Gly Met Asn Thr Met Ala Leu Val Ser Leu Ile Ser Ala Leu 
    130                 135                 140                 


Val Gly Val Leu Cys Cys Ile Gly Ser Ile Val Gly Ile Val Phe Gly 
145                 150                 155                 160 


Ala Ile Ala Ile Asn Gln Ile Lys Gln Thr Arg Glu Glu Gly Tyr Gly 
                165                 170                 175     


Leu Ala Val Ala Gly Ile Val Ile Gly Ile Ala Thr Leu Leu Val Tyr 
            180                 185                 190         


Met Ile Ala Gly Ile Phe Ala Ile Pro 
        195                 200     


<210>  17
<211>  597
<212>  DNA
<213>  Mycobacterium tuberculosis

<400>  17
atgacggctc ccagcggctc ctctggcgag agtgcgcacg acgccgcggg tggaccgcct       60

ccggtcggtg agcggccccc cgaacagccc attgctgacg ctccttgggc gccgccggca      120

tcttcgccga tggccaacca cccgcccccg gcgtatccgc cgtccggtta cccgcctgct      180

taccagcccg ggtatccgac cggctatcca ccgccgatgc cacccggggg ctatgcgccg      240

cccggatatc caccccccgg cacttcttca gcaggctacg gcgacatacc atacccgccc      300

atgcctccgc catacggtgg atctccgggc ggctactacc cggagccggg ctacctagac      360

ggctacggcc catcgcagcc cggcatgaac accatggcgc tcgtctcact gatctcggcg      420

ctcgtcggtg tgctttgctg catcggctcg atcgtgggca tcgtgttcgg cgcgatcgcc      480

atcaaccaga tcaagcagac acgcgaagaa ggctacggcc tggcggtggc cggcattgtg      540

attggcatcg cgaccctgct ggtctacatg atcgcgggga tcttcgctat cccttag         597


<210>  18
<211>  198
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  18

Met Thr Ala Pro Ser Gly Ser Ser Gly Glu Ser Ala His Asp Ala Ala 
1               5                   10                  15      


Gly Gly Pro Pro Pro Val Gly Glu Arg Pro Pro Glu Gln Pro Ile Ala 
            20                  25                  30          


Asp Ala Pro Trp Ala Pro Pro Ala Ser Ser Pro Met Ala Asn His Pro 
        35                  40                  45              


Pro Pro Ala Tyr Pro Pro Ser Gly Tyr Pro Pro Ala Tyr Gln Pro Gly 
    50                  55                  60                  


Tyr Pro Thr Gly Tyr Pro Pro Pro Met Pro Pro Gly Gly Tyr Ala Pro 
65                  70                  75                  80  


Pro Gly Tyr Pro Pro Pro Gly Thr Ser Ser Ala Gly Tyr Gly Asp Ile 
                85                  90                  95      


Pro Tyr Pro Pro Met Pro Pro Pro Tyr Gly Gly Ser Pro Gly Gly Tyr 
            100                 105                 110         


Tyr Pro Glu Pro Gly Tyr Leu Asp Gly Tyr Gly Pro Ser Gln Pro Gly 
        115                 120                 125             


Met Asn Thr Met Ala Leu Val Ser Leu Ile Ser Ala Leu Val Gly Val 
    130                 135                 140                 


Leu Cys Cys Ile Gly Ser Ile Val Gly Ile Val Phe Gly Ala Ile Ala 
145                 150                 155                 160 


Ile Asn Gln Ile Lys Gln Thr Arg Glu Glu Gly Tyr Gly Leu Ala Val 
                165                 170                 175     


Ala Gly Ile Val Ile Gly Ile Ala Thr Leu Leu Val Tyr Met Ile Ala 
            180                 185                 190         


Gly Ile Phe Ala Ile Pro 
        195             


<210>  19
<211>  597
<212>  DNA
<213>  Mycobacterium bovis

<400>  19
atgacggctc ccagcggctc ctctggcgag agtgcgcacg acgccgcggg tggaccgcct       60

ccggtcggtg agcggccccc cgaacagccc attgctgacg ctccttgggc gccgccggca      120

tcttcgccga tggccgacca cccgcccccg gcgtatccgc cgtccggtta cccgcctgct      180

taccagcccg ggtatccgac cgactatcca ccgccgatgc cacccggggg ctatgcgccg      240

cccggatatc caccccccgg cacttcttca gcaggctacg gcgacatacc atacccgccc      300

atgcctccgc catacggtgg atctccgggc ggctactacc cggagccggg ctacctagac      360

ggctacggcc catcgcagcc cggcatgaac accatggcgc tcgtctcact gatctcggcg      420

ctcgtcggtg tgctttgctg catcggctcg atcgtgggca tcgtgttcgg cgcgatcgcc      480

atcaaccaga tcaagcagac acgcgaagaa ggctacggcc tggcggtggc cggcattgtg      540

attggcatcg cgaccctgct ggtctacatg atcgcgggga tcttcgctat cccttag         597


<210>  20
<211>  198
<212>  PRT
<213>  Mycobacterium bovis

<400>  20

Met Thr Ala Pro Ser Gly Ser Ser Gly Glu Ser Ala His Asp Ala Ala 
1               5                   10                  15      


Gly Gly Pro Pro Pro Val Gly Glu Arg Pro Pro Glu Gln Pro Ile Ala 
            20                  25                  30          


Asp Ala Pro Trp Ala Pro Pro Ala Ser Ser Pro Met Ala Asp His Pro 
        35                  40                  45              


Pro Pro Ala Tyr Pro Pro Ser Gly Tyr Pro Pro Ala Tyr Gln Pro Gly 
    50                  55                  60                  


Tyr Pro Thr Asp Tyr Pro Pro Pro Met Pro Pro Gly Gly Tyr Ala Pro 
65                  70                  75                  80  


Pro Gly Tyr Pro Pro Pro Gly Thr Ser Ser Ala Gly Tyr Gly Asp Ile 
                85                  90                  95      


Pro Tyr Pro Pro Met Pro Pro Pro Tyr Gly Gly Ser Pro Gly Gly Tyr 
            100                 105                 110         


Tyr Pro Glu Pro Gly Tyr Leu Asp Gly Tyr Gly Pro Ser Gln Pro Gly 
        115                 120                 125             


Met Asn Thr Met Ala Leu Val Ser Leu Ile Ser Ala Leu Val Gly Val 
    130                 135                 140                 


Leu Cys Cys Ile Gly Ser Ile Val Gly Ile Val Phe Gly Ala Ile Ala 
145                 150                 155                 160 


Ile Asn Gln Ile Lys Gln Thr Arg Glu Glu Gly Tyr Gly Leu Ala Val 
                165                 170                 175     


Ala Gly Ile Val Ile Gly Ile Ala Thr Leu Leu Val Tyr Met Ile Ala 
            180                 185                 190         


Gly Ile Phe Ala Ile Pro 
        195             


<210>  21
<211>  615
<212>  DNA
<213>  Mycobacterium leprae

<400>  21
atgacagctc ccggcgacgc cttcggcgag agtgcccacg aagatgaggc gaacccgcca       60

gccgttacga ggcccccaag acagccggtt tggggtggcc cctggcatcc gaccgcacca      120

ccgcacgcag ccgatcacac gcacgcgaca tatccgctac ctgatgttcc tccaggctat      180

ccgtcggacc ttccgaccga ctatccagaa cccatagcgc ccaccccacc gggatacgga      240

caaccgctaa gctatggtgg gccgccctac ccaccgccgc aatttggcac acctgcaact      300

ggccatggtc ctgggtcact ttggcatccg ggtgaatatc caggcaacta tccggggggc      360

tactatccgc cgaattacct ggggggttac ggagcaacac agccaggaat gaacgtgatg      420

gcgatcgcct cgctaatatc ctcgttcgcc gggttggtgt gctgcatagg ctcgatcctg      480

gccatcgtgc tcggcgccat cgccctcgag cagaccaagc ggactcgcca agaaggctac      540

ggcctagccg ttgccggcat agtgatcggg atcgcgaccc tgctggtgag tttgaccgtc      600

gcagtattcg cgctg                                                       615


<210>  22
<211>  205
<212>  PRT
<213>  Mycobacterium leprae

<400>  22

Met Thr Ala Pro Gly Asp Ala Phe Gly Glu Ser Ala His Glu Asp Glu 
1               5                   10                  15      


Ala Asn Pro Pro Ala Val Thr Arg Pro Pro Arg Gln Pro Val Trp Gly 
            20                  25                  30          


Gly Pro Trp His Pro Thr Ala Pro Pro His Ala Ala Asp His Thr His 
        35                  40                  45              


Ala Thr Tyr Pro Leu Pro Asp Val Pro Pro Gly Tyr Pro Ser Asp Leu 
    50                  55                  60                  


Pro Thr Asp Tyr Pro Glu Pro Ile Ala Pro Thr Pro Pro Gly Tyr Gly 
65                  70                  75                  80  


Gln Pro Leu Ser Tyr Gly Gly Pro Pro Tyr Pro Pro Pro Gln Phe Gly 
                85                  90                  95      


Thr Pro Ala Thr Gly His Gly Pro Gly Ser Leu Trp His Pro Gly Glu 
            100                 105                 110         


Tyr Pro Gly Asn Tyr Pro Gly Gly Tyr Tyr Pro Pro Asn Tyr Leu Gly 
        115                 120                 125             


Gly Tyr Gly Ala Thr Gln Pro Gly Met Asn Val Met Ala Ile Ala Ser 
    130                 135                 140                 


Leu Ile Ser Ser Phe Ala Gly Leu Val Cys Cys Ile Gly Ser Ile Leu 
145                 150                 155                 160 


Ala Ile Val Leu Gly Ala Ile Ala Leu Glu Gln Thr Lys Arg Thr Arg 
                165                 170                 175     


Gln Glu Gly Tyr Gly Leu Ala Val Ala Gly Ile Val Ile Gly Ile Ala 
            180                 185                 190         


Thr Leu Leu Val Ser Leu Thr Val Ala Val Phe Ala Leu 
        195                 200                 205 


<210>  23
<211>  753
<212>  DNA
<213>  Mycobacterium avium

<400>  23
atgagcggcc attccaagtg ggccaccacc aagcacaaga aggccgtcat cgacgcccgc       60

cgcggcaaga tgttcgcccg gctgatcaag aacatcgagg tcgcggcccg cgtcggtggc      120

ggtgatccgg cgggcaaccc gacgctctac gacgcgatcc agaaggcgaa gaagagctcg      180

gtgcccaacg agaacatcga gcgggcgcgc aagcgcggcg ccggcgagga ggccggcggc      240

gccgactggc agaccatcac ctacgagggg tatgcgccca acggcgtggc ggtgctgatc      300

gagtgcctga ccgacaaccg caaccgcgcc gccagcgagg tgcgggtggc gatgactcgc      360

aacggcggca ccatggccga tccgggttcg gtgtcctacc tgttctcccg caagagcgtc      420

gtcacctgtg agaagaacgg cctgaccgag gacgacatcc tggcggccgt gctggatgcc      480

ggcgccgaag aggtcgagga cctcggcgac agcttcgaaa tcatctgcga gccaaccgat      540

ctcgtcgcgg tgcggacggc gctgcaggac gcgggcatcg actacgactc cgccgaggcg      600

ggattccagc cgtcggtgac ggtgccgctg aacgccgacg gcgcgcagaa ggtgatgcgg      660

ctggtcgacg cgctcgagga cagcgacgac gtccaggacg tgtggaccaa cgccgacatt      720

cccgacgaga tcctggccca gatcgaggag tga                                   753


<210>  24
<211>  250
<212>  PRT
<213>  Mycobacterium avium

<400>  24

Met Ser Gly His Ser Lys Trp Ala Thr Thr Lys His Lys Lys Ala Val 
1               5                   10                  15      


Ile Asp Ala Arg Arg Gly Lys Met Phe Ala Arg Leu Ile Lys Asn Ile 
            20                  25                  30          


Glu Val Ala Ala Arg Val Gly Gly Gly Asp Pro Ala Gly Asn Pro Thr 
        35                  40                  45              


Leu Tyr Asp Ala Ile Gln Lys Ala Lys Lys Ser Ser Val Pro Asn Glu 
    50                  55                  60                  


Asn Ile Glu Arg Ala Arg Lys Arg Gly Ala Gly Glu Glu Ala Gly Gly 
65                  70                  75                  80  


Ala Asp Trp Gln Thr Ile Thr Tyr Glu Gly Tyr Ala Pro Asn Gly Val 
                85                  90                  95      


Ala Val Leu Ile Glu Cys Leu Thr Asp Asn Arg Asn Arg Ala Ala Ser 
            100                 105                 110         


Glu Val Arg Val Ala Met Thr Arg Asn Gly Gly Thr Met Ala Asp Pro 
        115                 120                 125             


Gly Ser Val Ser Tyr Leu Phe Ser Arg Lys Ser Val Val Thr Cys Glu 
    130                 135                 140                 


Lys Asn Gly Leu Thr Glu Asp Asp Ile Leu Ala Ala Val Leu Asp Ala 
145                 150                 155                 160 


Gly Ala Glu Glu Val Glu Asp Leu Gly Asp Ser Phe Glu Ile Ile Cys 
                165                 170                 175     


Glu Pro Thr Asp Leu Val Ala Val Arg Thr Ala Leu Gln Asp Ala Gly 
            180                 185                 190         


Ile Asp Tyr Asp Ser Ala Glu Ala Gly Phe Gln Pro Ser Val Thr Val 
        195                 200                 205             


Pro Leu Asn Ala Asp Gly Ala Gln Lys Val Met Arg Leu Val Asp Ala 
    210                 215                 220                 


Leu Glu Asp Ser Asp Asp Val Gln Asp Val Trp Thr Asn Ala Asp Ile 
225                 230                 235                 240 


Pro Asp Glu Ile Leu Ala Gln Ile Glu Glu 
                245                 250 


<210>  25
<211>  753
<212>  DNA
<213>  Mycobacterium avium

<400>  25
tcactcctcg atctgggcca ggatctcgtc gggaatgtcg gcgttggtcc acacgtcctg       60

gacgtcgtcg ctgtcctcga gcgcgtcgac cagccgcatc accttctgcg cgccgtcggc      120

gtccagcggc accgtcaccg acggctggaa tcccgcctcg gcggagtcgt agtcgatgcc      180

ggcgtcctgc agcgccgtcc gcaccgcgac gagatcggtt ggctcgcaga tgatttcgaa      240

gctgtcgccg aggtcctcga cctcttcggc gccggcgtcc agcacggccg ccaggatgtc      300

gtcctcggtc aggccgttct tctcacaggt gacgacgccc ttgcgggaga acaggtagga      360

caccgaaccc gggtcggcca tggtgccgcc gttgcgggtc atcgccaccc gcacctcgct      420

ggcggcgcgg ttgcggttgt cggtcaggca ctcgatcagc accgccacgc cgttgggcgc      480

atacccctcg taggtgatgg tctgccagtc ggcgccgccg gcctcctcgc cggcgccgcg      540

tttgcgggcc cgctcgatgt tctcgttggg caccgagctc ttcttcgcct tctggatcgc      600

gtcgtagagc gtcgggttgc ccgccggatc accgccaccg acgcgggccg cgacctcgat      660

gttcttgatc agccgggcga acatcttgcc gcggcgggcg tcgatgacgg ccttcttgtg      720

cttggtggtg gcccacttgg aatggccgct cat                                   753


<210>  26
<211>  250
<212>  PRT
<213>  Mycobacterium avium

<400>  26

Met Ser Gly His Ser Lys Trp Ala Thr Thr Lys His Lys Lys Ala Val 
1               5                   10                  15      


Ile Asp Ala Arg Arg Gly Lys Met Phe Ala Arg Leu Ile Lys Asn Ile 
            20                  25                  30          


Glu Val Ala Ala Arg Val Gly Gly Gly Asp Pro Ala Gly Asn Pro Thr 
        35                  40                  45              


Leu Tyr Asp Ala Ile Gln Lys Ala Lys Lys Ser Ser Val Pro Asn Glu 
    50                  55                  60                  


Asn Ile Glu Arg Ala Arg Lys Arg Gly Ala Gly Glu Glu Ala Gly Gly 
65                  70                  75                  80  


Ala Asp Trp Gln Thr Ile Thr Tyr Glu Gly Tyr Ala Pro Asn Gly Val 
                85                  90                  95      


Ala Val Leu Ile Glu Cys Leu Thr Asp Asn Arg Asn Arg Ala Ala Ser 
            100                 105                 110         


Glu Val Arg Val Ala Met Thr Arg Asn Gly Gly Thr Met Ala Asp Pro 
        115                 120                 125             


Gly Ser Val Ser Tyr Leu Phe Ser Arg Lys Gly Val Val Thr Cys Glu 
    130                 135                 140                 


Lys Asn Gly Leu Thr Glu Asp Asp Ile Leu Ala Ala Val Leu Asp Ala 
145                 150                 155                 160 


Gly Ala Glu Glu Val Glu Asp Leu Gly Asp Ser Phe Glu Ile Ile Cys 
                165                 170                 175     


Glu Pro Thr Asp Leu Val Ala Val Arg Thr Ala Leu Gln Asp Ala Gly 
            180                 185                 190         


Ile Asp Tyr Asp Ser Ala Glu Ala Gly Phe Gln Pro Ser Val Thr Val 
        195                 200                 205             


Pro Leu Asp Ala Asp Gly Ala Gln Lys Val Met Arg Leu Val Asp Ala 
    210                 215                 220                 


Leu Glu Asp Ser Asp Asp Val Gln Asp Val Trp Thr Asn Ala Asp Ile 
225                 230                 235                 240 


Pro Asp Glu Ile Leu Ala Gln Ile Glu Glu 
                245                 250 


