                         SEQUENCE LISTING

<110>  MIVAC Development AB
 
<120>  COMPOSITIONS AND METHODS FOR THE TREATMENT OF AUTOIMMUNE AND 
       ALLERGIC DISEASES

<130>  90159

<150>  SE 0702825-1
<151>  2007-12-19

<160>  4     

<170>  PatentIn version 3.3

<210>  1
<211>  194
<212>  PRT
<213>  Vibrio cholerae


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  R7K MUTATION

<400>  1

Asn Asp Asp Lys Leu Tyr Lys Ala Asp Ser Arg Pro Pro Asp Glu Ile 
1               5                   10                  15      


Lys Gln Ser Gly Gly Leu Met Pro Arg Gly Gln Ser Glu Tyr Phe Asp 
            20                  25                  30          


Arg Gly Thr Gln Met Asn Ile Asn Leu Tyr Asp His Ala Arg Gly Thr 
        35                  40                  45              


Gln Thr Gly Phe Val Arg His Asp Asp Gly Tyr Val Ser Thr Ser Ile 
    50                  55                  60                  


Ser Leu Arg Ser Ala His Leu Val Gly Gln Thr Ile Leu Ser Gly His 
65                  70                  75                  80  


Ser Thr Tyr Tyr Ile Tyr Val Ile Ala Thr Ala Pro Asn Met Phe Asn 
                85                  90                  95      


Val Asn Asp Val Leu Gly Ala Tyr Ser Pro His Pro Asp Glu Gln Glu 
            100                 105                 110         


Val Ser Ala Leu Gly Gly Ile Pro Tyr Ser Gln Ile Tyr Gly Trp Tyr 
        115                 120                 125             


Arg Val His Phe Gly Val Leu Asp Glu Gln Leu His Arg Asn Arg Gly 
    130                 135                 140                 


Tyr Arg Asp Arg Tyr Tyr Ser Asn Leu Asp Ile Ala Pro Ala Ala Asp 
145                 150                 155                 160 


Gly Tyr Gly Leu Ala Gly Phe Pro Pro Glu His Arg Ala Trp Arg Glu 
                165                 170                 175     


Glu Pro Trp Ile His His Ala Pro Pro Gly Cys Gly Asn Ala Pro Arg 
            180                 185                 190         


Ser Ser 
        


<210>  2
<211>  1050
<212>  DNA
<213>  Artificial

<220>
<223>  SYNTHETHIC FUSION PROTEIN


<220>
<221>  CDS
<222>  (1)..(1050)

<400>  2
atg gat gat aag tta tat aag gca gat tct aga cct cct gat gaa ata       48
Met Asp Asp Lys Leu Tyr Lys Ala Asp Ser Arg Pro Pro Asp Glu Ile         
1               5                   10                  15              

aag cag tca ggt ggt ctt atg cca aga gga cag agt gag tac ttt gac       96
Lys Gln Ser Gly Gly Leu Met Pro Arg Gly Gln Ser Glu Tyr Phe Asp         
            20                  25                  30                  

cga ggt act caa atg aat atc aac ctt tat gat cat gca aga gga act      144
Arg Gly Thr Gln Met Asn Ile Asn Leu Tyr Asp His Ala Arg Gly Thr         
        35                  40                  45                      

cag acg gga ttt gtt agg cac gat gat gga tat gtt tcc acc tca att      192
Gln Thr Gly Phe Val Arg His Asp Asp Gly Tyr Val Ser Thr Ser Ile         
    50                  55                  60                          

agt ttg aga agt gcc cac tta gtg ggt caa act ata ttg tct ggt cat      240
Ser Leu Arg Ser Ala His Leu Val Gly Gln Thr Ile Leu Ser Gly His         
65                  70                  75                  80          

tct act tat tat ata tat gtt ata gcc act gca ccc aac atg ttt aac      288
Ser Thr Tyr Tyr Ile Tyr Val Ile Ala Thr Ala Pro Asn Met Phe Asn         
                85                  90                  95              

gtt aat gat gta tta ggg gca tac agt cct cat cca gat gaa caa gaa      336
Val Asn Asp Val Leu Gly Ala Tyr Ser Pro His Pro Asp Glu Gln Glu         
            100                 105                 110                 

gtt tct gct tta ggt ggg att cca tac tcc caa ata tat gga tgg tat      384
Val Ser Ala Leu Gly Gly Ile Pro Tyr Ser Gln Ile Tyr Gly Trp Tyr         
        115                 120                 125                     

cga gtt cat ttt ggg gtg ctt gat gaa caa tta cat cgt aat agg ggc      432
Arg Val His Phe Gly Val Leu Asp Glu Gln Leu His Arg Asn Arg Gly         
    130                 135                 140                         

tac aga gat aga tat tac agt aac tta gat att gct cca gca gca gat      480
Tyr Arg Asp Arg Tyr Tyr Ser Asn Leu Asp Ile Ala Pro Ala Ala Asp         
145                 150                 155                 160         

ggt tat gga ttg gca ggt ttc cct ccg gag cat aga gct tgg agg gaa      528
Gly Tyr Gly Leu Ala Gly Phe Pro Pro Glu His Arg Ala Trp Arg Glu         
                165                 170                 175             

gag ccg tgg att cat cat gca ccg ccg ggt tgt ggg aat gct cca aga      576
Glu Pro Trp Ile His His Ala Pro Pro Gly Cys Gly Asn Ala Pro Arg         
            180                 185                 190                 

tca tcg gga tcc ggg aag aca ccc gag ggt att gct ggc ttc aaa ggt      624
Ser Ser Gly Ser Gly Lys Thr Pro Glu Gly Ile Ala Gly Phe Lys Gly         
        195                 200                 205                     

gaa caa ggc ccc aag gga gaa cct ggc ccc gag gct gat gcg caa caa      672
Glu Gln Gly Pro Lys Gly Glu Pro Gly Pro Glu Ala Asp Ala Gln Gln         
    210                 215                 220                         

aat aac ttc aac aaa gat caa caa agc gcc ttc tat gaa atc ttg aac      720
Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu Asn         
225                 230                 235                 240         

atg cct aac tta aac gaa gcg caa cgt aac ggc ttc att caa agt ctt      768
Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu         
                245                 250                 255             

aaa gac gac cca agc caa agc act aac gtt tta ggt gaa gct aaa aaa      816
Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys         
            260                 265                 270                 

tta aac gaa tct caa gca ccc aaa ccc gag gct gat gcg caa caa aat      864
Leu Asn Glu Ser Gln Ala Pro Lys Pro Glu Ala Asp Ala Gln Gln Asn         
        275                 280                 285                     

aac ttc aac aaa gat caa caa agc gcc ttc tat gaa atc ttg aac atg      912
Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu Asn Met         
    290                 295                 300                         

cct aac tta aac gaa gcg caa cgt aac ggc ttc att caa agt ctt aaa      960
Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys         
305                 310                 315                 320         

gac gac cca agc caa agc act aac gtt tta ggt gaa gct aaa aaa tta     1008
Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu         
                325                 330                 335             

aac gaa tct caa gca ccc aaa ccc gag gta gca ggt cag aat             1050
Asn Glu Ser Gln Ala Pro Lys Pro Glu Val Ala Gly Gln Asn                 
            340                 345                 350                 


<210>  3
<211>  350
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  3

Met Asp Asp Lys Leu Tyr Lys Ala Asp Ser Arg Pro Pro Asp Glu Ile 
1               5                   10                  15      


Lys Gln Ser Gly Gly Leu Met Pro Arg Gly Gln Ser Glu Tyr Phe Asp 
            20                  25                  30          


Arg Gly Thr Gln Met Asn Ile Asn Leu Tyr Asp His Ala Arg Gly Thr 
        35                  40                  45              


Gln Thr Gly Phe Val Arg His Asp Asp Gly Tyr Val Ser Thr Ser Ile 
    50                  55                  60                  


Ser Leu Arg Ser Ala His Leu Val Gly Gln Thr Ile Leu Ser Gly His 
65                  70                  75                  80  


Ser Thr Tyr Tyr Ile Tyr Val Ile Ala Thr Ala Pro Asn Met Phe Asn 
                85                  90                  95      


Val Asn Asp Val Leu Gly Ala Tyr Ser Pro His Pro Asp Glu Gln Glu 
            100                 105                 110         


Val Ser Ala Leu Gly Gly Ile Pro Tyr Ser Gln Ile Tyr Gly Trp Tyr 
        115                 120                 125             


Arg Val His Phe Gly Val Leu Asp Glu Gln Leu His Arg Asn Arg Gly 
    130                 135                 140                 


Tyr Arg Asp Arg Tyr Tyr Ser Asn Leu Asp Ile Ala Pro Ala Ala Asp 
145                 150                 155                 160 


Gly Tyr Gly Leu Ala Gly Phe Pro Pro Glu His Arg Ala Trp Arg Glu 
                165                 170                 175     


Glu Pro Trp Ile His His Ala Pro Pro Gly Cys Gly Asn Ala Pro Arg 
            180                 185                 190         


Ser Ser Gly Ser Gly Lys Thr Pro Glu Gly Ile Ala Gly Phe Lys Gly 
        195                 200                 205             


Glu Gln Gly Pro Lys Gly Glu Pro Gly Pro Glu Ala Asp Ala Gln Gln 
    210                 215                 220                 


Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu Asn 
225                 230                 235                 240 


Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu 
                245                 250                 255     


Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys 
            260                 265                 270         


Leu Asn Glu Ser Gln Ala Pro Lys Pro Glu Ala Asp Ala Gln Gln Asn 
        275                 280                 285             


Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu Asn Met 
    290                 295                 300                 


Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys 
305                 310                 315                 320 


Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu 
                325                 330                 335     


Asn Glu Ser Gln Ala Pro Lys Pro Glu Val Ala Gly Gln Asn 
            340                 345                 350 


<210>  4
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  SYNTHETIC PEPTIDE

<400>  4

Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Pro 
1               5                   10                  


