                         SEQUENCE LISTING

<110>  Syngenta Participations AG
       Jucovic, Milan
       Chen, Jeng  S.
       Walters, Frederick  S.
       Palekar, Narendra   V.
 
<120>  Engineering Zymogens for Conditional Toxicity

<130>  71749WOPCT

<150>  US 61/012864
<151>  2007-12-11

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  1
tatacatatg ctgcagaacc tgaagatcac c                                      31


<210>  2
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  2
tctagatgca tgctcgagct aggacgtcag cagggt                                 36


<210>  3
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  3
tctagatgca tgctcgagtc acttcacttc actgta                                 36


<210>  4
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (50)..(51)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (71)..(72)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (74)..(75)
<223>  n is a, c, g, or t

<400>  4
gatcaggacg tccgtaggat gggtannsnn snnsggtgaa gtattcnnsn nstgggtaca       60

tggaggatgg nnsnnstaga tctgttgtac acaaagtgga gtag                       104


<210>  5
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  5
gagcgtccca aaaccttctc aag                                               23


<210>  6
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chemically synthesized

<400>  6

Val Gly Trp Val Pro Ser Arg Gly Glu Val Phe Ser Leu Trp Val His 
1               5                   10                  15      


Gly Gly Trp Ala Arg 
            20      


<210>  7
<211>  21
<212>  PRT
<213>  Artificial Sequece

<220>
<223>  Chemically synthesized


<220>
<221>  PEPTIDE
<222>  (1)..(21)
<223>  "Xaa" is any amino acid.

<400>  7

Xaa Xaa Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Trp Xaa Xaa 
            20      


<210>  8
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  "Xaa" is Thr or Ala

<400>  8

Val Gly Trp Val Met Trp Ala Gly Val Val Phe Trp Ala Leu Gly Thr 
1               5                   10                  15      


Trp Arg Met Gly His Val Asp Leu Leu Tyr Thr Lys Trp Ser Ser Gln 
            20                  25                  30          


Ser Ser Ile Arg Asn Gln Xaa Ala Pro Asp Phe Tyr Ser Tyr Ser Glu 
        35                  40                  45              


Val Lys 
    50  


<210>  9
<211>  462
<212>  PRT
<213>  Bacillus cereus

<400>  9

Met Lys Arg Met Glu Gly Lys Leu Phe Met Val Ser Lys Lys Leu Gln 
1               5                   10                  15      


Val Val Thr Lys Thr Val Leu Leu Ser Thr Val Phe Ser Ile Ser Leu 
            20                  25                  30          


Leu Asn Asn Glu Val Ile Lys Ala Glu Gln Leu Asn Ile Asn Ser Gln 
        35                  40                  45              


Ser Lys Tyr Thr Asn Leu Gln Asn Leu Lys Ile Thr Asp Lys Val Glu 
    50                  55                  60                  


Asp Phe Lys Glu Asp Lys Glu Lys Ala Lys Glu Trp Gly Lys Glu Lys 
65                  70                  75                  80  


Glu Lys Glu Trp Lys Leu Thr Ala Thr Glu Lys Gly Lys Met Asn Asn 
                85                  90                  95      


Phe Leu Asp Asn Lys Asn Asp Ile Lys Thr Asn Tyr Lys Glu Ile Thr 
            100                 105                 110         


Phe Ser Met Ala Gly Ser Phe Glu Asp Glu Ile Lys Asp Leu Lys Glu 
        115                 120                 125             


Ile Asp Lys Met Phe Asp Lys Thr Asn Leu Ser Asn Ser Ile Ile Thr 
    130                 135                 140                 


Tyr Lys Asn Val Glu Pro Thr Thr Ile Gly Phe Asn Lys Ser Leu Thr 
145                 150                 155                 160 


Glu Gly Asn Thr Ile Asn Ser Asp Ala Met Ala Gln Phe Lys Glu Gln 
                165                 170                 175     


Phe Leu Asp Arg Asp Ile Lys Phe Asp Ser Tyr Leu Asp Thr His Leu 
            180                 185                 190         


Thr Ala Gln Gln Val Ser Ser Lys Glu Arg Val Ile Leu Lys Val Thr 
        195                 200                 205             


Val Pro Ser Gly Lys Gly Ser Thr Thr Pro Thr Lys Ala Gly Val Ile 
    210                 215                 220                 


Leu Asn Asn Ser Glu Tyr Lys Met Leu Ile Asp Asn Gly Tyr Met Val 
225                 230                 235                 240 


His Val Asp Lys Val Ser Lys Val Val Lys Lys Gly Val Glu Cys Leu 
                245                 250                 255     


Gln Ile Glu Gly Thr Leu Lys Lys Ser Leu Asp Phe Lys Asn Asp Ile 
            260                 265                 270         


Asn Ala Glu Ala His Ser Trp Gly Met Lys Asn Tyr Glu Glu Trp Ala 
        275                 280                 285             


Lys Asp Leu Thr Asp Ser Gln Arg Glu Ala Leu Asp Gly Tyr Ala Arg 
    290                 295                 300                 


Gln Asp Tyr Lys Glu Ile Asn Asn Tyr Leu Arg Asn Gln Gly Gly Ser 
305                 310                 315                 320 


Gly Asn Glu Lys Leu Asp Ala Gln Ile Lys Asn Ile Ser Asp Ala Leu 
                325                 330                 335     


Gly Lys Lys Pro Ile Pro Glu Asn Ile Thr Val Tyr Arg Trp Cys Gly 
            340                 345                 350         


Met Pro Glu Phe Gly Tyr Gln Ile Ser Asp Pro Leu Pro Ser Leu Lys 
        355                 360                 365             


Asp Phe Glu Glu Gln Phe Leu Asn Thr Ile Lys Glu Asp Lys Gly Tyr 
    370                 375                 380                 


Met Ser Thr Ser Leu Ser Ser Glu Arg Leu Ala Ala Phe Gly Ser Arg 
385                 390                 395                 400 


Lys Ile Ile Leu Arg Leu Gln Val Pro Lys Gly Ser Thr Gly Ala Tyr 
                405                 410                 415     


Leu Ser Ala Ile Gly Gly Phe Ala Ser Glu Lys Glu Ile Leu Leu Asp 
            420                 425                 430         


Lys Asp Ser Lys Tyr His Ile Asp Lys Val Thr Glu Val Ile Ile Lys 
        435                 440                 445             


Gly Val Lys Arg Tyr Val Val Asp Ala Thr Leu Leu Thr Asn 
    450                 455                 460         


<210>  10
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated Vip2 without bacterial secretion signal.


<220>
<221>  MISC_FEATURE
<222>  (410)..(410)
<223>  "Xaa" is Asn or Ser

<400>  10

Met Leu Gln Asn Leu Lys Ile Thr Asp Lys Val Glu Asp Phe Lys Glu 
1               5                   10                  15      


Asp Lys Glu Lys Ala Lys Glu Trp Gly Lys Glu Lys Glu Lys Glu Trp 
            20                  25                  30          


Lys Leu Thr Ala Thr Glu Lys Gly Lys Met Asn Asn Phe Leu Asp Asn 
        35                  40                  45              


Lys Asn Asp Ile Lys Thr Asn Tyr Lys Glu Ile Thr Phe Ser Met Ala 
    50                  55                  60                  


Gly Ser Phe Glu Asp Glu Ile Lys Asp Leu Lys Glu Ile Asp Lys Met 
65                  70                  75                  80  


Phe Asp Lys Thr Asn Leu Ser Asn Ser Ile Ile Thr Tyr Lys Asn Val 
                85                  90                  95      


Glu Pro Thr Thr Ile Gly Phe Asn Lys Ser Leu Thr Glu Gly Asn Thr 
            100                 105                 110         


Ile Asn Ser Asp Ala Met Ala Gln Phe Lys Glu Gln Phe Leu Asp Arg 
        115                 120                 125             


Asp Ile Lys Phe Asp Ser Tyr Leu Asp Thr His Leu Thr Ala Gln Gln 
    130                 135                 140                 


Val Ser Ser Lys Glu Arg Val Ile Leu Lys Val Thr Val Pro Ser Gly 
145                 150                 155                 160 


Lys Gly Ser Thr Thr Pro Thr Lys Ala Gly Val Ile Leu Asn Asn Ser 
                165                 170                 175     


Glu Tyr Lys Met Leu Ile Asp Asn Gly Tyr Met Val His Val Asp Lys 
            180                 185                 190         


Val Ser Lys Val Val Lys Lys Gly Val Glu Cys Leu Gln Ile Glu Gly 
        195                 200                 205             


Thr Leu Lys Lys Ser Leu Asp Phe Lys Asn Asp Ile Asn Ala Glu Ala 
    210                 215                 220                 


His Ser Trp Gly Met Lys Asn Tyr Glu Glu Trp Ala Lys Asp Leu Thr 
225                 230                 235                 240 


Asp Ser Gln Arg Glu Ala Leu Asp Gly Tyr Ala Arg Gln Asp Tyr Lys 
                245                 250                 255     


Glu Ile Asn Asn Tyr Leu Arg Asn Gln Gly Gly Ser Gly Asn Glu Lys 
            260                 265                 270         


Leu Asp Ala Gln Ile Lys Asn Ile Ser Asp Ala Leu Gly Lys Lys Pro 
        275                 280                 285             


Ile Pro Glu Asn Ile Thr Val Tyr Arg Trp Cys Gly Met Pro Glu Phe 
    290                 295                 300                 


Gly Tyr Gln Ile Ser Asp Pro Leu Pro Ser Leu Lys Asp Phe Glu Glu 
305                 310                 315                 320 


Gln Phe Leu Asn Thr Ile Lys Glu Asp Lys Gly Tyr Met Ser Thr Ser 
                325                 330                 335     


Leu Ser Ser Glu Arg Leu Ala Ala Phe Gly Ser Arg Lys Ile Ile Leu 
            340                 345                 350         


Arg Leu Gln Val Pro Lys Gly Ser Thr Gly Ala Tyr Leu Ser Ala Ile 
        355                 360                 365             


Gly Gly Phe Ala Ser Glu Lys Glu Ile Leu Leu Asp Lys Asp Ser Lys 
    370                 375                 380                 


Tyr His Ile Asp Lys Val Thr Glu Val Ile Ile Lys Gly Val Lys Arg 
385                 390                 395                 400 


Tyr Val Val Asp Ala Thr Leu Leu Thr Xaa 
                405                 410 


<210>  11
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemiocally synthesized


<220>
<221>  MISC_FEATURE
<222>  (410)..(410)
<223>  "Xaa" is Asn or Ser

<400>  11

Met Leu Gln Asn Leu Lys Ile Thr Asp Lys Val Glu Asp Phe Lys Glu 
1               5                   10                  15      


Asp Lys Glu Lys Ala Lys Glu Trp Gly Lys Glu Lys Glu Lys Glu Trp 
            20                  25                  30          


Lys Leu Thr Ala Thr Glu Lys Gly Lys Met Asn Asn Phe Leu Asp Asn 
        35                  40                  45              


Lys Asn Asp Ile Lys Thr Asn Tyr Lys Glu Ile Thr Phe Ser Met Ala 
    50                  55                  60                  


Gly Ser Phe Glu Asp Glu Ile Lys Asp Leu Lys Glu Ile Asp Lys Met 
65                  70                  75                  80  


Phe Asp Lys Thr Asn Leu Ser Asn Ser Ile Ile Thr Tyr Lys Asn Val 
                85                  90                  95      


Glu Pro Thr Thr Ile Gly Phe Asn Lys Ser Leu Thr Glu Gly Asn Thr 
            100                 105                 110         


Ile Asn Ser Asp Ala Met Ala Gln Phe Lys Glu Gln Phe Leu Asp Arg 
        115                 120                 125             


Asp Ile Lys Phe Asp Ser Tyr Leu Asp Thr His Leu Thr Ala Gln Gln 
    130                 135                 140                 


Val Ser Ser Lys Glu Arg Val Ile Leu Lys Val Thr Val Pro Ser Gly 
145                 150                 155                 160 


Lys Gly Ser Thr Thr Pro Thr Lys Ala Gly Val Ile Leu Asn Asn Ser 
                165                 170                 175     


Glu Tyr Lys Met Leu Ile Asp Asn Gly Tyr Met Val His Val Asp Lys 
            180                 185                 190         


Val Ser Lys Val Val Lys Lys Gly Val Glu Cys Leu Gln Ile Glu Gly 
        195                 200                 205             


Thr Leu Lys Lys Ser Leu Asp Phe Lys Asn Asp Ile Asn Ala Glu Ala 
    210                 215                 220                 


His Ser Trp Gly Met Lys Asn Tyr Glu Glu Trp Ala Lys Asp Leu Thr 
225                 230                 235                 240 


Asp Ser Gln Arg Glu Ala Leu Asp Gly Tyr Ala Arg Gln Asp Tyr Lys 
                245                 250                 255     


Glu Ile Asn Asn Tyr Leu Arg Asn Gln Gly Gly Ser Gly Asn Glu Lys 
            260                 265                 270         


Leu Asp Ala Gln Ile Lys Asn Ile Ser Asp Ala Leu Gly Lys Lys Pro 
        275                 280                 285             


Ile Pro Glu Asn Ile Thr Val Tyr Arg Trp Cys Gly Met Pro Glu Phe 
    290                 295                 300                 


Gly Tyr Gln Ile Ser Asp Pro Leu Pro Ser Leu Lys Asp Phe Glu Glu 
305                 310                 315                 320 


Gln Phe Leu Asn Thr Ile Lys Glu Asp Lys Gly Tyr Met Ser Thr Ser 
                325                 330                 335     


Leu Ser Ser Glu Arg Leu Ala Ala Phe Gly Ser Arg Lys Ile Ile Leu 
            340                 345                 350         


Arg Leu Gln Val Pro Lys Gly Ser Thr Gly Ala Tyr Leu Ser Ala Ile 
        355                 360                 365             


Gly Gly Phe Ala Ser Glu Lys Glu Ile Leu Leu Asp Lys Asp Ser Lys 
    370                 375                 380                 


Tyr His Ile Asp Lys Val Thr Glu Val Ile Ile Lys Gly Val Lys Arg 
385                 390                 395                 400 


Tyr Val Val Asp Ala Thr Leu Leu Thr Xaa Val Gly Trp Val Pro Ser 
                405                 410                 415     


Arg Gly Glu Val Phe Ser Leu Trp Val His Gly Gly Trp Ala Arg 
            420                 425                 430     


<210>  12
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (410)..(410)
<223>  "Xaa" is Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (449)..(449)
<223>  "Xaa" is Thr or Ala

<400>  12

Met Leu Gln Asn Leu Lys Ile Thr Asp Lys Val Glu Asp Phe Lys Glu 
1               5                   10                  15      


Asp Lys Glu Lys Ala Lys Glu Trp Gly Lys Glu Lys Glu Lys Glu Trp 
            20                  25                  30          


Lys Leu Thr Ala Thr Glu Lys Gly Lys Met Asn Asn Phe Leu Asp Asn 
        35                  40                  45              


Lys Asn Asp Ile Lys Thr Asn Tyr Lys Glu Ile Thr Phe Ser Met Ala 
    50                  55                  60                  


Gly Ser Phe Glu Asp Glu Ile Lys Asp Leu Lys Glu Ile Asp Lys Met 
65                  70                  75                  80  


Phe Asp Lys Thr Asn Leu Ser Asn Ser Ile Ile Thr Tyr Lys Asn Val 
                85                  90                  95      


Glu Pro Thr Thr Ile Gly Phe Asn Lys Ser Leu Thr Glu Gly Asn Thr 
            100                 105                 110         


Ile Asn Ser Asp Ala Met Ala Gln Phe Lys Glu Gln Phe Leu Asp Arg 
        115                 120                 125             


Asp Ile Lys Phe Asp Ser Tyr Leu Asp Thr His Leu Thr Ala Gln Gln 
    130                 135                 140                 


Val Ser Ser Lys Glu Arg Val Ile Leu Lys Val Thr Val Pro Ser Gly 
145                 150                 155                 160 


Lys Gly Ser Thr Thr Pro Thr Lys Ala Gly Val Ile Leu Asn Asn Ser 
                165                 170                 175     


Glu Tyr Lys Met Leu Ile Asp Asn Gly Tyr Met Val His Val Asp Lys 
            180                 185                 190         


Val Ser Lys Val Val Lys Lys Gly Val Glu Cys Leu Gln Ile Glu Gly 
        195                 200                 205             


Thr Leu Lys Lys Ser Leu Asp Phe Lys Asn Asp Ile Asn Ala Glu Ala 
    210                 215                 220                 


His Ser Trp Gly Met Lys Asn Tyr Glu Glu Trp Ala Lys Asp Leu Thr 
225                 230                 235                 240 


Asp Ser Gln Arg Glu Ala Leu Asp Gly Tyr Ala Arg Gln Asp Tyr Lys 
                245                 250                 255     


Glu Ile Asn Asn Tyr Leu Arg Asn Gln Gly Gly Ser Gly Asn Glu Lys 
            260                 265                 270         


Leu Asp Ala Gln Ile Lys Asn Ile Ser Asp Ala Leu Gly Lys Lys Pro 
        275                 280                 285             


Ile Pro Glu Asn Ile Thr Val Tyr Arg Trp Cys Gly Met Pro Glu Phe 
    290                 295                 300                 


Gly Tyr Gln Ile Ser Asp Pro Leu Pro Ser Leu Lys Asp Phe Glu Glu 
305                 310                 315                 320 


Gln Phe Leu Asn Thr Ile Lys Glu Asp Lys Gly Tyr Met Ser Thr Ser 
                325                 330                 335     


Leu Ser Ser Glu Arg Leu Ala Ala Phe Gly Ser Arg Lys Ile Ile Leu 
            340                 345                 350         


Arg Leu Gln Val Pro Lys Gly Ser Thr Gly Ala Tyr Leu Ser Ala Ile 
        355                 360                 365             


Gly Gly Phe Ala Ser Glu Lys Glu Ile Leu Leu Asp Lys Asp Ser Lys 
    370                 375                 380                 


Tyr His Ile Asp Lys Val Thr Glu Val Ile Ile Lys Gly Val Lys Arg 
385                 390                 395                 400 


Tyr Val Val Asp Ala Thr Leu Leu Thr Xaa Val Gly Trp Val Met Trp 
                405                 410                 415     


Ala Gly Val Val Phe Trp Ala Leu Gly Thr Trp Arg Met Gly His Val 
            420                 425                 430         


Asp Leu Leu Tyr Thr Lys Trp Ser Ser Gln Ser Ser Ile Arg Asn Gln 
        435                 440                 445             


Xaa Ala Pro Asp Phe Tyr Ser Tyr Ser Glu Val Lys 
    450                 455                 460 


<210>  13
<211>  13299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  13
cgcgccagct tgcacatgac aacaattgta agaggatgga gaccacaacg atccaacaat       60

acttctgcga cgggctgtga agtatagaga agttaaacgc ccaaaagcca ttgtgtttgg      120

aatttttagt tattctattt ttcatgatgt atcttcctct aacatgcctt aatttgcaaa      180

tttggtataa ctactgattg aaaatatatg tatgtaaaaa aatactaagc atatttgtga      240

agctaaacat gatgttattt aagaaaatat gttgttaaca gaataagatt aatatcgaaa      300

tggaaacatc tgtaaattag aatcatctta caagctaaga gatgttcacg ctttgagaaa      360

cttcttcaga tcatgaccgt agaagtagct ctccaagact caacgaaggc tgctgcaatt      420

ccacaaatgc atgacatgca tccttgtaac cgtcgtcgcc gctataaaca cggataactc      480

aattccctgc tccatcaatt tagaaatgag caagcaagca cccgatcgct caccccatat      540

gcaccaatct gactcccaag ctctgtttcg cattagtacc gccagcactc cacctatagc      600

taccaattga gacctttcca gcctaagcag atcgattgat cgttagagtc aaagagttgg      660

tggtacgggt actttaacta ccatggaatg atggggcgtg atgtagagcg gaaagcgcct      720

ccctacgcgg aacaacaccc tcgccatgcc gctcgactac agcctcctcc tcgtcggcgc      780

cacaacgagg gagcccgtgg tcgcagccac cgaccagcat gtctctgtgt cctcgtccga      840

cctcgacatg tcatggcaaa cagtcggacg ccagcaccag actgacgaca tgagtctctg      900

aagagcccgc cacctagaaa gatccgagcc ctgctgctgg tagtggtaac cattttcgtc      960

gcgctgacgc ggagagcgag aggccagaaa tttatagcga ctgacgctgt ggcaggcacg     1020

ctatcggagg ttacgacgtg gcgggtcact cgacgcggag ttcacaggtc ctatccttgc     1080

atcgctcggc gcggagttta cggggactta tccttacgac gtgctctaag gttgcgataa     1140

cgggcggagg aaggcgtgtg gcgtgcggag acggtttata cacgtagtgt gcgggagtgt     1200

gtttcgtaga cgcgggaaag cacgacgact tacgaaggtt agtggaggag gaggacacac     1260

taaaatcagg acgcaagaaa ctcttctatt atagtagtag agaagagatt ataggagtgt     1320

gggttgattc taaagaaaat cgacgcagga caaccgtcaa aacgggtgct ttaatatagt     1380

agatatatat atatagagag agagagaaag tacaaaggat gcatttgtgt ctgcatatga     1440

tcggagtatt actaacggcc gtcgtaagaa ggtccatcat gcgtggagcg agcccatttg     1500

gttggttgtc aggccgcagt taaggcctcc atatatgatt gtcgtcgggc ccataacagc     1560

atctcctcca ccagtttatt gtaagaataa attaagtaga gatatttgtc gtcgggcaga     1620

agaaacttgg acaagaagaa gaagcaagct aggccaattt cttgccggca agaggaagat     1680

agtggcctct agtttatata tcggcgtgat gatgatgctc ctagctagaa atgagagaag     1740

aaaaacggac gcgtgtttgg tgtgtgtcaa tggcgtccat ccttccatca gatcagaacg     1800

atgaaaaagt caagcacggc atgcatagta tatgtatagc ttgttttagt gtggctttgc     1860

tgagacgaat gaaagcaacg gcgggcatat ttttcagtgg ctgtagcttt caggctgaaa     1920

gagacgtggc atgcaataat tcagggaatt cgtcagccaa ttgaggtagc tagtcaactt     1980

gtacattggt gcgagcaatt ttccgcactc aggagggcta gtttgagagt ccaaaaacta     2040

taggagatta aagaggctaa aatcctctcc ttatttaatt ttaaataagt agtgtatttg     2100

tattttaact cctccaaccc ttccgatttt atggctctca aactagcatt cagtctaatg     2160

catgcatgct tggctagagg tcgtatgggg ttgttaatag catagctagc tacaagttaa     2220

ccgggtcttt tatatttaat aaggacaggc aaagtattac ttacaaataa agaataaagc     2280

taggacgaac tgctggatta ttactaaatc gaaatggacg taatattcca ggcaagaata     2340

attgttcgat caggagacaa gtggggcatt ggaccggttc ttgcaagcaa gagcctatgg     2400

cgtggtgaca cggcgcgttg cccatacatc atgcctccat cgatgatcca tcctcacttg     2460

ctataaaaag aggtgtccat ggtgctcaag ctcagccaag caaataagac gacttgtttc     2520

attgattctt caagagatcg agcttctttt gcaccacaag gtcgaggatc caccatgatg     2580

agagccctgg cgtggtggcc atgctggccc gccttcttcg ctgtgcccgc tcgcgccctg     2640

cagaacctga agatcaccga caaggtggag gacttcaagg aggacaagga gaaggccaag     2700

gagtggggca aggagaagga gaaggagtgg aagcttaccg ccaccgagaa gggcaagatg     2760

aacaacttcc tggacaacaa gaacgacatc aagaccaact acaaggagat caccttcagc     2820

atggccggca gcttcgagga cgagatcaag gacctgaagg agatcgacaa gatgttcgac     2880

aagaccaacc tgagcaacag catcatcacc tacaagaacg tggagcccac caccatcggc     2940

ttcaacaaga gcctgaccga gggcaacacc atcaacagcg acgccatggc ccagttcaag     3000

gagcagttcc tggaccgcga catcaagttc gacagctacc tggacaccca cctgaccgcc     3060

cagcaggtga gcagcaagga gcgcgtgatc ctgaaggtga ccgtccccag cggcaagggc     3120

agcaccaccc ccaccaaggc cggcgtgatc ctgaacaaca gcgagtacaa gatgctgatc     3180

gacaacggct acatggtgca cgtggacaag gtgagcaagg tggtgaagaa gggcgtggag     3240

tgcctccaga tcgagggcac cctgaagaag agtctagact tcaagaacga catcaacgcc     3300

gaggcccaca gctggggcat gaagaactac gaggagtggg ccaaggacct gaccgacagc     3360

cagcgcgagg ccctggacgg ctacgcccgc caggactaca aggagatcaa caactacctg     3420

cgcaaccagg gcggcagcgg caacgagaag ctggacgccc agatcaagaa catcagcgac     3480

gccctcggca agaagcccat ccccgagaac atcaccgtgt accgatggtg cggcatgccc     3540

gagttcggct accagatcag cgaccccctg cccagcctga aggacttcga ggagcagttc     3600

ctgaacacca tcaaggagga caagggctac atgagcacca gcctgagcag cgagcgcctg     3660

gccgccttcg gcagccgcaa gatcatcctg cgcctgcagg tgcccaaggg cagcactggt     3720

gcctacctga gcgccatcgg cggcttcgcc agcgagaagg agatcctgct ggataaggac     3780

agcaagtacc acatcgacaa ggtgaccgag gtgatcatca agggcgtgaa gcgctacgtg     3840

gtggacgcca ccctgctgac gtccgtagga tgggtaatgt gggcgggtgt agtattctgg     3900

gcgctgggta catggaggat ggggcacgta gatctgttgt acacaaagtg gagtagtcag     3960

tcatcgatca ggaaccagac accagacttt tattcataca gtgaagtgaa gtgaagtgca     4020

gtgcagtgag ttgctggttt ttgtacaact tagtatgtat ttgtatttgt aaaatacttc     4080

tatcaataaa atttctaatt cctaaaacca aaatccaggg gtacccgggg atcctctaga     4140

gtcgaccatg gtgatcactg caggcatgca agcttgcatg cctgcagtgc agcgtgaccc     4200

ggtcgtgccc ctctctagag ataatgagca ttgcatgtct aagttataaa aaattaccac     4260

atattttttt tgtcacactt gtttgaagtg cagtttatct atctttatac atatatttaa     4320

actttactct acgaataata taatctatag tactacaata atatcagtgt tttagagaat     4380

catataaatg aacagttaga catggtctaa aggacaattg agtattttga caacaggact     4440

ctacagtttt atctttttag tgtgcatgtg ttctcctttt tttttgcaaa tagcttcacc     4500

tatataatac ttcatccatt ttattagtac atccatttag ggtttagggt taatggtttt     4560

tatagactaa tttttttagt acatctattt tattctattt tagcctctaa attaagaaaa     4620

ctaaaactct attttagttt ttttatttaa taatttagat ataaaataga ataaaataaa     4680

gtgactaaaa attaaacaaa taccctttaa gaaattaaaa aaactaagga aacatttttc     4740

ttgtttcgag tagataatgc cagcctgtta aacgccgtcg acgagtctaa cggacaccaa     4800

ccagcgaacc agcagcgtcg cgtcgggcca agcgaagcag acggcacggc atctctgtcg     4860

ctgcctctgg acccctctcg agagttccgc tccaccgttg gacttgctcc gctgtcggca     4920

tccagaaatt gcgtggcgga gcggcagacg tgagccggca cggcaggcgg cctcctcctc     4980

ctctcacggc accggcagct acgggggatt cctttcccac cgctccttcg ctttcccttc     5040

ctcgcccgcc gtaataaata gacaccccct ccacaccctc tttccccaac ctcgtgttgt     5100

tcggagcgca cacacacaca accagatctc ccccaaatcc acccgtcggc acctccgctt     5160

caaggtacgc cgctcgtcct cccccccccc ccctctctac cttctctaga tcggcgttcc     5220

ggtccatggt tagggcccgg tagttctact tctgttcatg tttgtgttag atccgtgttt     5280

gtgttagatc cgtgctgcta gcgttcgtac acggatgcga cctgtacgtc agacacgttc     5340

tgattgctaa cttgccagtg tttctctttg gggaatcctg ggatggctct agccgttccg     5400

cagacgggat cgatttcatg attttttttg tttcgttgca tagggtttgg tttgcccttt     5460

tcctttattt caatatatgc cgtgcacttg tttgtcgggt catcttttca tgcttttttt     5520

tgtcttggtt gtgatgatgt ggtctggttg ggcggtcgtt ctagatcgga gtagaattct     5580

gtttcaaact acctggtgga tttattaatt ttggatctgt atgtgtgtgc catacatatt     5640

catagttacg aattgaagat gatggatgga aatatcgatc taggataggt atacatgttg     5700

atgcgggttt tactgatgca tatacagaga tgctttttgt tcgcttggtt gtgatgatgt     5760

ggtgtggttg ggcggtcgtt cattcgttct agatcggagt agaatactgt ttcaaactac     5820

ctggtgtatt tattaatttt ggaactgtat gtgtgtgtca tacatcttca tagttacgag     5880

tttaagatgg atggaaatat cgatctagga taggtataca tgttgatgtg ggttttactg     5940

atgcatatac atgatggcat atgcagcatc tattcatatg ctctaacctt gagtacctat     6000

ctattataat aaacaagtat gttttataat tattttgatc ttgatatact tggatgatgg     6060

catatgcagc agctatatgt ggattttttt agccctgcct tcatacgcta tttatttgct     6120

tggtactgtt tcttttgtcg atgctcaccc tgttgtttgg tgttacttct gcagggatcc     6180

ccgatcatgc aaaaactcat taactcagtg caaaactatg cctggggcag caaaacggcg     6240

ttgactgaac tttatggtat ggaaaatccg tccagccagc cgatggccga gctgtggatg     6300

ggcgcacatc cgaaaagcag ttcacgagtg cagaatgccg ccggagatat cgtttcactg     6360

cgtgatgtga ttgagagtga taaatcgact ctgctcggag aggccgttgc caaacgcttt     6420

ggcgaactgc ctttcctgtt caaagtatta tgcgcagcac agccactctc cattcaggtt     6480

catccaaaca aacacaattc tgaaatcggt tttgccaaag aaaatgccgc aggtatcccg     6540

atggatgccg ccgagcgtaa ctataaagat cctaaccaca agccggagct ggtttttgcg     6600

ctgacgcctt tccttgcgat gaacgcgttt cgtgaatttt ccgagattgt ctccctactc     6660

cagccggtcg caggtgcaca tccggcgatt gctcactttt tacaacagcc tgatgccgaa     6720

cgtttaagcg aactgttcgc cagcctgttg aatatgcagg gtgaagaaaa atcccgcgcg     6780

ctggcgattt taaaatcggc cctcgatagc cagcagggtg aaccgtggca aacgattcgt     6840

ttaatttctg aattttaccc ggaagacagc ggtctgttct ccccgctatt gctgaatgtg     6900

gtgaaattga accctggcga agcgatgttc ctgttcgctg aaacaccgca cgcttacctg     6960

caaggcgtgg cgctggaagt gatggcaaac tccgataacg tgctgcgtgc gggtctgacg     7020

cctaaataca ttgatattcc ggaactggtt gccaatgtga aattcgaagc caaaccggct     7080

aaccagttgt tgacccagcc ggtgaaacaa ggtgcagaac tggacttccc gattccagtg     7140

gatgattttg ccttctcgct gcatgacctt agtgataaag aaaccaccat tagccagcag     7200

agtgccgcca ttttgttctg cgtcgaaggc gatgcaacgt tgtggaaagg ttctcagcag     7260

ttacagctta aaccgggtga atcagcgttt attgccgcca acgaatcacc ggtgactgtc     7320

aaaggccacg gccgtttagc gcgtgtttac aacaagctgt aagagcttac tgaaaaaatt     7380

aacatctctt gctaagctgg gagctcgatc cgtcgacctg cagatcgttc aaacatttgg     7440

caataaagtt tcttaagatt gaatcctgtt gccggtcttg cgatgattat catataattt     7500

ctgttgaatt acgttaagca tgtaataatt aacatgtaat gcatgacgtt atttatgaga     7560

tgggttttta tgattagagt cccgcaatta tacatttaat acgcgataga aaacaaaata     7620

tagcgcgcaa actaggataa attatcgcgc gcggtgtcat ctatgttact agatctgcta     7680

gccctgcagg aaatttaccg gtgcccgggc ggccagcatg gccgtatccg caatgtgtta     7740

ttaagttgtc taagcgtcaa tttgtttaca ccacaatata tcctgccacc agccagccaa     7800

cagctccccg accggcagct cggcacaaaa tcaccactcg atacaggcag cccatcagaa     7860

ttaattctca tgtttgacag cttatcatcg actgcacggt gcaccaatgc ttctggcgtc     7920

aggcagccat cggaagctgt ggtatggctg tgcaggtcgt aaatcactgc ataattcgtg     7980

tcgctcaagg cgcactcccg ttctggataa tgttttttgc gccgacatca taacggttct     8040

ggcaaatatt ctgaaatgag ctgttgacaa ttaatcatcc ggctcgtata atgtgtggaa     8100

ttgtgagcgg ataacaattt cacacaggaa acagaccatg agggaagcgt tgatcgccga     8160

agtatcgact caactatcag aggtagttgg cgtcatcgag cgccatctcg aaccgacgtt     8220

gctggccgta catttgtacg gctccgcagt ggatggcggc ctgaagccac acagtgatat     8280

tgatttgctg gttacggtga ccgtaaggct tgatgaaaca acgcggcgag ctttgatcaa     8340

cgaccttttg gaaacttcgg cttcccctgg agagagcgag attctccgcg ctgtagaagt     8400

caccattgtt gtgcacgacg acatcattcc gtggcgttat ccagctaagc gcgaactgca     8460

atttggagaa tggcagcgca atgacattct tgcaggtatc ttcgagccag ccacgatcga     8520

cattgatctg gctatcttgc tgacaaaagc aagagaacat agcgttgcct tggtaggtcc     8580

agcggcggag gaactctttg atccggttcc tgaacaggat ctatttgagg cgctaaatga     8640

aaccttaacg ctatggaact cgccgcccga ctgggctggc gatgagcgaa atgtagtgct     8700

tacgttgtcc cgcatttggt acagcgcagt aaccggcaaa atcgcgccga aggatgtcgc     8760

tgccgactgg gcaatggagc gcctgccggc ccagtatcag cccgtcatac ttgaagctag     8820

gcaggcttat cttggacaag aagatcgctt ggcctcgcgc gcagatcagt tggaagaatt     8880

tgttcactac gtgaaaggcg agatcaccaa agtagtcggc aaataaagct ctagtggatc     8940

tccgtacccc cgggggatct ggctcgcggc ggacgcacga cgccggggcg agaccatagg     9000

cgatctccta aatcaatagt agctgtaacc tcgaagcgtt tcacttgtaa caacgattga     9060

gaatttttgt cataaaattg aaatacttgg ttcgcatttt tgtcatccgc ggtcagccgc     9120

aattctgacg aactgcccat ttagctggag atgattgtac atccttcacg tgaaaatttc     9180

tcaagcgctg tgaacaaggg ttcagatttt agattgaaag gtgagccgtt gaaacacgtt     9240

cttcttgtcg atgacgacgt cgctatgcgg catcttatta ttgaatacct tacgatccac     9300

gccttcaaag tgaccgcggt agccgacagc acccagttca caagagtact ctcttccgcg     9360

acggtcgatg tcgtggttgt tgatctaaat ttaggtcgtg aagatgggct cgagatcgtt     9420

cgtaatctgg cggcaaagtc tgatattcca atcataatta tcagtggcga ccgccttgag     9480

gagacggata aagttgttgc actcgagcta ggagcaagtg attttatcgc taagccgttc     9540

agtatcagag agtttctagc acgcattcgg gttgccttgc gcgtgcgccc caacgttgtc     9600

cgctccaaag accgacggtc tttttgtttt actgactgga cacttaatct caggcaacgt     9660

cgcttgatgt ccgaagctgg cggtgaggtg aaacttacgg caggtgagtt caatcttctc     9720

ctcgcgtttt tagagaaacc ccgcgacgtt ctatcgcgcg agcaacttct cattgccagt     9780

cgagtacgcg acgaggaggt ttatgacagg agtatagatg ttctcatttt gaggctgcgc     9840

cgcaaacttg aggcagatcc gtcaagccct caactgataa aaacagcaag aggtgccggt     9900

tatttctttg acgcggacgt gcaggtttcg cacgggggga cgatggcagc ctgagccaat     9960

tcccagatcc ccgaggaatc ggcgtgagcg gtcgcaaacc atccggcccg gtacaaatcg    10020

gcgcggcgct gggtgatgac ctggtggaga agttgaaggc cgcgcaggcc gcccagcggc    10080

aacgcatcga ggcagaagca cgccccggtg aatcgtggca agcggccgct gatcgaatcc    10140

gcaaagaatc ccggcaaccg ccggcagccg gtgcgccgtc gattaggaag ccgcccaagg    10200

gcgacgagca accagatttt ttcgttccga tgctctatga cgtgggcacc cgcgatagtc    10260

gcagcatcat ggacgtggcc gttttccgtc tgtcgaagcg tgaccgacga gctggcgagg    10320

tgatccgcta cgagcttcca gacgggcacg tagaggtttc cgcagggccg gccggcatgg    10380

ccagtgtgtg ggattacgac ctggtactga tggcggtttc ccatctaacc gaatccatga    10440

accgataccg ggaagggaag ggagacaagc ccggccgcgt gttccgtcca cacgttgcgg    10500

acgtactcaa gttctgccgg cgagccgatg gcggaaagca gaaagacgac ctggtagaaa    10560

cctgcattcg gttaaacacc acgcacgttg ccatgcagcg tacgaagaag gccaagaacg    10620

gccgcctggt gacggtatcc gagggtgaag ccttgattag ccgctacaag atcgtaaaga    10680

gcgaaaccgg gcggccggag tacatcgaga tcgagctagc tgattggatg taccgcgaga    10740

tcacagaagg caagaacccg gacgtgctga cggttcaccc cgattacttt ttgatcgatc    10800

ccggcatcgg ccgttttctc taccgcctgg cacgccgcgc cgcaggcaag gcagaagcca    10860

gatggttgtt caagacgatc tacgaacgca gtggcagcgc cggagagttc aagaagttct    10920

gtttcaccgt gcgcaagctg atcgggtcaa atgacctgcc ggagtacgat ttgaaggagg    10980

aggcggggca ggctggcccg atcctagtca tgcgctaccg caacctgatc gagggcgaag    11040

catccgccgg ttcctaatgt acggagcaga tgctagggca aattgcccta gcaggggaaa    11100

aaggtcgaaa aggtctcttt cctgtggata gcacgtacat tgggaaccca aagccgtaca    11160

ttgggaaccg gaacccgtac attgggaacc caaagccgta cattgggaac cggtcacaca    11220

tgtaagtgac tgatataaaa gagaaaaaag gcgatttttc cgcctaaaac tctttaaaac    11280

ttattaaaac tcttaaaacc cgcctggcct gtgcataact gtctggccag cgcacagccg    11340

aagagctgca aaaagcgcct acccttcggt cgctgcgctc cctacgcccc gccgcttcgc    11400

gtcggcctat cgcggccgct ggccgctcaa aaatggctgg cctacggcca ggcaatctac    11460

cagggcgcgg acaagccgcg ccgtcgccac tcgaccgccg gcgctgaggt ctgcctcgtg    11520

aagaaggtgt tgctgactca taccaggcct gaatcgcccc atcatccagc cagaaagtga    11580

gggagccacg gttgatgaga gctttgttgt aggtggacca gttggtgatt ttgaactttt    11640

gctttgccac ggaacggtct gcgttgtcgg gaagatgcgt gatctgatcc ttcaactcag    11700

caaaagttcg atttattcaa caaagccgcc gtcccgtcaa gtcagcgtaa tgctctgcca    11760

gtgttacaac caattaacca attctgatta gaaaaactca tcgagcatca aatgaaactg    11820

caatttattc atatcaggat tatcaatacc atatttttga aaaagccgtt tctgtaatga    11880

aggagaaaac tcaccgaggc agttccatag gatggcaaga tcctggtatc ggtctgcgat    11940

tccgactcgt ccaacatcaa tacaacctat taatttcccc tcgtcaaaaa taaggttatc    12000

aagtgagaaa tcaccatgag tgacgactga atccggtgag aatggcaaaa gctctgcatt    12060

aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct    12120

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa    12180

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa    12240

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc    12300

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga    12360

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc    12420

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt    12480

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct    12540

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg    12600

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta    12660

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct    12720

acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa    12780

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt    12840

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta    12900

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat    12960

caaaaaggat cttcacctag atccttttga tccggaatta attcctgtgg ttggcatgca    13020

catacaaatg gacgaacgga taaacctttt cacgcccttt taaatatccg attattctaa    13080

taaacgctct tttctcttag gtttacccgc caatatatcc tgtcaaacac tgatagttta    13140

aactgaaggc gggaaacgac aatctgatca tgagcggaga attaagggag tcacgttatg    13200

acccccgccg atgacgcggg acaagccgtt ttacgtttgg aactgacaga accgcaacgc    13260

tgcaggaatt ggccgcagcg gccatttaaa tcaattggg                           13299


<210>  14
<211>  13317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  14
cgcgccagct tgcacatgac aacaattgta agaggatgga gaccacaacg atccaacaat       60

acttctgcga cgggctgtga agtatagaga agttaaacgc ccaaaagcca ttgtgtttgg      120

aatttttagt tattctattt ttcatgatgt atcttcctct aacatgcctt aatttgcaaa      180

tttggtataa ctactgattg aaaatatatg tatgtaaaaa aatactaagc atatttgtga      240

agctaaacat gatgttattt aagaaaatat gttgttaaca gaataagatt aatatcgaaa      300

tggaaacatc tgtaaattag aatcatctta caagctaaga gatgttcacg ctttgagaaa      360

cttcttcaga tcatgaccgt agaagtagct ctccaagact caacgaaggc tgctgcaatt      420

ccacaaatgc atgacatgca tccttgtaac cgtcgtcgcc gctataaaca cggataactc      480

aattccctgc tccatcaatt tagaaatgag caagcaagca cccgatcgct caccccatat      540

gcaccaatct gactcccaag ctctgtttcg cattagtacc gccagcactc cacctatagc      600

taccaattga gacctttcca gcctaagcag atcgattgat cgttagagtc aaagagttgg      660

tggtacgggt actttaacta ccatggaatg atggggcgtg atgtagagcg gaaagcgcct      720

ccctacgcgg aacaacaccc tcgccatgcc gctcgactac agcctcctcc tcgtcggcgc      780

cacaacgagg gagcccgtgg tcgcagccac cgaccagcat gtctctgtgt cctcgtccga      840

cctcgacatg tcatggcaaa cagtcggacg ccagcaccag actgacgaca tgagtctctg      900

aagagcccgc cacctagaaa gatccgagcc ctgctgctgg tagtggtaac cattttcgtc      960

gcgctgacgc ggagagcgag aggccagaaa tttatagcga ctgacgctgt ggcaggcacg     1020

ctatcggagg ttacgacgtg gcgggtcact cgacgcggag ttcacaggtc ctatccttgc     1080

atcgctcggc gcggagttta cggggactta tccttacgac gtgctctaag gttgcgataa     1140

cgggcggagg aaggcgtgtg gcgtgcggag acggtttata cacgtagtgt gcgggagtgt     1200

gtttcgtaga cgcgggaaag cacgacgact tacgaaggtt agtggaggag gaggacacac     1260

taaaatcagg acgcaagaaa ctcttctatt atagtagtag agaagagatt ataggagtgt     1320

gggttgattc taaagaaaat cgacgcagga caaccgtcaa aacgggtgct ttaatatagt     1380

agatatatat atatagagag agagagaaag tacaaaggat gcatttgtgt ctgcatatga     1440

tcggagtatt actaacggcc gtcgtaagaa ggtccatcat gcgtggagcg agcccatttg     1500

gttggttgtc aggccgcagt taaggcctcc atatatgatt gtcgtcgggc ccataacagc     1560

atctcctcca ccagtttatt gtaagaataa attaagtaga gatatttgtc gtcgggcaga     1620

agaaacttgg acaagaagaa gaagcaagct aggccaattt cttgccggca agaggaagat     1680

agtggcctct agtttatata tcggcgtgat gatgatgctc ctagctagaa atgagagaag     1740

aaaaacggac gcgtgtttgg tgtgtgtcaa tggcgtccat ccttccatca gatcagaacg     1800

atgaaaaagt caagcacggc atgcatagta tatgtatagc ttgttttagt gtggctttgc     1860

tgagacgaat gaaagcaacg gcgggcatat ttttcagtgg ctgtagcttt caggctgaaa     1920

gagacgtggc atgcaataat tcagggaatt cgtcagccaa ttgaggtagc tagtcaactt     1980

gtacattggt gcgagcaatt ttccgcactc aggagggcta gtttgagagt ccaaaaacta     2040

taggagatta aagaggctaa aatcctctcc ttatttaatt ttaaataagt agtgtatttg     2100

tattttaact cctccaaccc ttccgatttt atggctctca aactagcatt cagtctaatg     2160

catgcatgct tggctagagg tcgtatgggg ttgttaatag catagctagc tacaagttaa     2220

ccgggtcttt tatatttaat aaggacaggc aaagtattac ttacaaataa agaataaagc     2280

taggacgaac tgctggatta ttactaaatc gaaatggacg taatattcca ggcaagaata     2340

attgttcgat caggagacaa gtggggcatt ggaccggttc ttgcaagcaa gagcctatgg     2400

cgtggtgaca cggcgcgttg cccatacatc atgcctccat cgatgatcca tcctcacttg     2460

ctataaaaag aggtgtccat ggtgctcaag ctcagccaag caaataagac gacttgtttc     2520

attgattctt caagagatcg agcttctttt gcaccacaag gtcgaggatc caccatggag     2580

gcatccaaca agctcgcagt cttgctcctg tggctggtca tggcagctgc cactgccgtg     2640

cacccttcct actctctgca gaacctgaag atcaccgaca aggtggagga cttcaaggag     2700

gacaaggaga aggccaagga gtggggcaag gagaaggaga aggagtggaa gcttaccgcc     2760

accgagaagg gcaagatgaa caacttcctg gacaacaaga acgacatcaa gaccaactac     2820

aaggagatca ccttcagcat ggccggcagc ttcgaggacg agatcaagga cctgaaggag     2880

atcgacaaga tgttcgacaa gaccaacctg agcaacagca tcatcaccta caagaacgtg     2940

gagcccacca ccatcggctt caacaagagc ctgaccgagg gcaacaccat caacagcgac     3000

gccatggccc agttcaagga gcagttcctg gaccgcgaca tcaagttcga cagctacctg     3060

gacacccacc tgaccgccca gcaggtgagc agcaaggagc gcgtgatcct gaaggtgacc     3120

gtccccagcg gcaagggcag caccaccccc accaaggccg gcgtgatcct gaacaacagc     3180

gagtacaaga tgctgatcga caacggctac atggtgcacg tggacaaggt gagcaaggtg     3240

gtgaagaagg gcgtggagtg cctccagatc gagggcaccc tgaagaagag tctagacttc     3300

aagaacgaca tcaacgccga ggcccacagc tggggcatga agaactacga ggagtgggcc     3360

aaggacctga ccgacagcca gcgcgaggcc ctggacggct acgcccgcca ggactacaag     3420

gagatcaaca actacctgcg caaccagggc ggcagcggca acgagaagct ggacgcccag     3480

atcaagaaca tcagcgacgc cctcggcaag aagcccatcc ccgagaacat caccgtgtac     3540

cgatggtgcg gcatgcccga gttcggctac cagatcagcg accccctgcc cagcctgaag     3600

gacttcgagg agcagttcct gaacaccatc aaggaggaca agggctacat gagcaccagc     3660

ctgagcagcg agcgcctggc cgccttcggc agccgcaaga tcatcctgcg cctgcaggtg     3720

cccaagggca gcactggtgc ctacctgagc gccatcggcg gcttcgccag cgagaaggag     3780

atcctgctgg ataaggacag caagtaccac atcgacaagg tgaccgaggt gatcatcaag     3840

ggcgtgaagc gctacgtggt ggacgccacc ctgctgacgt ccgtaggatg ggtaatgtgg     3900

gcgggtgtag tattctgggc gctgggtaca tggaggatgg ggcacgtaga tctgttgtac     3960

acaaagtgga gtagtcagtc atcgatcagg aaccagacac cagactttta ttcatacagt     4020

gaagtgaagt gaagtgcagt gcagtgagtt gctggttttt gtacaactta gtatgtattt     4080

gtatttgtaa aatacttcta tcaataaaat ttctaattcc taaaaccaaa atccaggggt     4140

acccggggat cctctagagt cgaccatggt gatcactgca ggcatgcaag cttgcatgcc     4200

tgcagtgcag cgtgacccgg tcgtgcccct ctctagagat aatgagcatt gcatgtctaa     4260

gttataaaaa attaccacat attttttttg tcacacttgt ttgaagtgca gtttatctat     4320

ctttatacat atatttaaac tttactctac gaataatata atctatagta ctacaataat     4380

atcagtgttt tagagaatca tataaatgaa cagttagaca tggtctaaag gacaattgag     4440

tattttgaca acaggactct acagttttat ctttttagtg tgcatgtgtt ctcctttttt     4500

tttgcaaata gcttcaccta tataatactt catccatttt attagtacat ccatttaggg     4560

tttagggtta atggttttta tagactaatt tttttagtac atctatttta ttctatttta     4620

gcctctaaat taagaaaact aaaactctat tttagttttt ttatttaata atttagatat     4680

aaaatagaat aaaataaagt gactaaaaat taaacaaata ccctttaaga aattaaaaaa     4740

actaaggaaa catttttctt gtttcgagta gataatgcca gcctgttaaa cgccgtcgac     4800

gagtctaacg gacaccaacc agcgaaccag cagcgtcgcg tcgggccaag cgaagcagac     4860

ggcacggcat ctctgtcgct gcctctggac ccctctcgag agttccgctc caccgttgga     4920

cttgctccgc tgtcggcatc cagaaattgc gtggcggagc ggcagacgtg agccggcacg     4980

gcaggcggcc tcctcctcct ctcacggcac cggcagctac gggggattcc tttcccaccg     5040

ctccttcgct ttcccttcct cgcccgccgt aataaataga caccccctcc acaccctctt     5100

tccccaacct cgtgttgttc ggagcgcaca cacacacaac cagatctccc ccaaatccac     5160

ccgtcggcac ctccgcttca aggtacgccg ctcgtcctcc cccccccccc ctctctacct     5220

tctctagatc ggcgttccgg tccatggtta gggcccggta gttctacttc tgttcatgtt     5280

tgtgttagat ccgtgtttgt gttagatccg tgctgctagc gttcgtacac ggatgcgacc     5340

tgtacgtcag acacgttctg attgctaact tgccagtgtt tctctttggg gaatcctggg     5400

atggctctag ccgttccgca gacgggatcg atttcatgat tttttttgtt tcgttgcata     5460

gggtttggtt tgcccttttc ctttatttca atatatgccg tgcacttgtt tgtcgggtca     5520

tcttttcatg cttttttttg tcttggttgt gatgatgtgg tctggttggg cggtcgttct     5580

agatcggagt agaattctgt ttcaaactac ctggtggatt tattaatttt ggatctgtat     5640

gtgtgtgcca tacatattca tagttacgaa ttgaagatga tggatggaaa tatcgatcta     5700

ggataggtat acatgttgat gcgggtttta ctgatgcata tacagagatg ctttttgttc     5760

gcttggttgt gatgatgtgg tgtggttggg cggtcgttca ttcgttctag atcggagtag     5820

aatactgttt caaactacct ggtgtattta ttaattttgg aactgtatgt gtgtgtcata     5880

catcttcata gttacgagtt taagatggat ggaaatatcg atctaggata ggtatacatg     5940

ttgatgtggg ttttactgat gcatatacat gatggcatat gcagcatcta ttcatatgct     6000

ctaaccttga gtacctatct attataataa acaagtatgt tttataatta ttttgatctt     6060

gatatacttg gatgatggca tatgcagcag ctatatgtgg atttttttag ccctgccttc     6120

atacgctatt tatttgcttg gtactgtttc ttttgtcgat gctcaccctg ttgtttggtg     6180

ttacttctgc agggatcccc gatcatgcaa aaactcatta actcagtgca aaactatgcc     6240

tggggcagca aaacggcgtt gactgaactt tatggtatgg aaaatccgtc cagccagccg     6300

atggccgagc tgtggatggg cgcacatccg aaaagcagtt cacgagtgca gaatgccgcc     6360

ggagatatcg tttcactgcg tgatgtgatt gagagtgata aatcgactct gctcggagag     6420

gccgttgcca aacgctttgg cgaactgcct ttcctgttca aagtattatg cgcagcacag     6480

ccactctcca ttcaggttca tccaaacaaa cacaattctg aaatcggttt tgccaaagaa     6540

aatgccgcag gtatcccgat ggatgccgcc gagcgtaact ataaagatcc taaccacaag     6600

ccggagctgg tttttgcgct gacgcctttc cttgcgatga acgcgtttcg tgaattttcc     6660

gagattgtct ccctactcca gccggtcgca ggtgcacatc cggcgattgc tcacttttta     6720

caacagcctg atgccgaacg tttaagcgaa ctgttcgcca gcctgttgaa tatgcagggt     6780

gaagaaaaat cccgcgcgct ggcgatttta aaatcggccc tcgatagcca gcagggtgaa     6840

ccgtggcaaa cgattcgttt aatttctgaa ttttacccgg aagacagcgg tctgttctcc     6900

ccgctattgc tgaatgtggt gaaattgaac cctggcgaag cgatgttcct gttcgctgaa     6960

acaccgcacg cttacctgca aggcgtggcg ctggaagtga tggcaaactc cgataacgtg     7020

ctgcgtgcgg gtctgacgcc taaatacatt gatattccgg aactggttgc caatgtgaaa     7080

ttcgaagcca aaccggctaa ccagttgttg acccagccgg tgaaacaagg tgcagaactg     7140

gacttcccga ttccagtgga tgattttgcc ttctcgctgc atgaccttag tgataaagaa     7200

accaccatta gccagcagag tgccgccatt ttgttctgcg tcgaaggcga tgcaacgttg     7260

tggaaaggtt ctcagcagtt acagcttaaa ccgggtgaat cagcgtttat tgccgccaac     7320

gaatcaccgg tgactgtcaa aggccacggc cgtttagcgc gtgtttacaa caagctgtaa     7380

gagcttactg aaaaaattaa catctcttgc taagctggga gctcgatccg tcgacctgca     7440

gatcgttcaa acatttggca ataaagtttc ttaagattga atcctgttgc cggtcttgcg     7500

atgattatca tataatttct gttgaattac gttaagcatg taataattaa catgtaatgc     7560

atgacgttat ttatgagatg ggtttttatg attagagtcc cgcaattata catttaatac     7620

gcgatagaaa acaaaatata gcgcgcaaac taggataaat tatcgcgcgc ggtgtcatct     7680

atgttactag atctgctagc cctgcaggaa atttaccggt gcccgggcgg ccagcatggc     7740

cgtatccgca atgtgttatt aagttgtcta agcgtcaatt tgtttacacc acaatatatc     7800

ctgccaccag ccagccaaca gctccccgac cggcagctcg gcacaaaatc accactcgat     7860

acaggcagcc catcagaatt aattctcatg tttgacagct tatcatcgac tgcacggtgc     7920

accaatgctt ctggcgtcag gcagccatcg gaagctgtgg tatggctgtg caggtcgtaa     7980

atcactgcat aattcgtgtc gctcaaggcg cactcccgtt ctggataatg ttttttgcgc     8040

cgacatcata acggttctgg caaatattct gaaatgagct gttgacaatt aatcatccgg     8100

ctcgtataat gtgtggaatt gtgagcggat aacaatttca cacaggaaac agaccatgag     8160

ggaagcgttg atcgccgaag tatcgactca actatcagag gtagttggcg tcatcgagcg     8220

ccatctcgaa ccgacgttgc tggccgtaca tttgtacggc tccgcagtgg atggcggcct     8280

gaagccacac agtgatattg atttgctggt tacggtgacc gtaaggcttg atgaaacaac     8340

gcggcgagct ttgatcaacg accttttgga aacttcggct tcccctggag agagcgagat     8400

tctccgcgct gtagaagtca ccattgttgt gcacgacgac atcattccgt ggcgttatcc     8460

agctaagcgc gaactgcaat ttggagaatg gcagcgcaat gacattcttg caggtatctt     8520

cgagccagcc acgatcgaca ttgatctggc tatcttgctg acaaaagcaa gagaacatag     8580

cgttgccttg gtaggtccag cggcggagga actctttgat ccggttcctg aacaggatct     8640

atttgaggcg ctaaatgaaa ccttaacgct atggaactcg ccgcccgact gggctggcga     8700

tgagcgaaat gtagtgctta cgttgtcccg catttggtac agcgcagtaa ccggcaaaat     8760

cgcgccgaag gatgtcgctg ccgactgggc aatggagcgc ctgccggccc agtatcagcc     8820

cgtcatactt gaagctaggc aggcttatct tggacaagaa gatcgcttgg cctcgcgcgc     8880

agatcagttg gaagaatttg ttcactacgt gaaaggcgag atcaccaaag tagtcggcaa     8940

ataaagctct agtggatctc cgtacccccg ggggatctgg ctcgcggcgg acgcacgacg     9000

ccggggcgag accataggcg atctcctaaa tcaatagtag ctgtaacctc gaagcgtttc     9060

acttgtaaca acgattgaga atttttgtca taaaattgaa atacttggtt cgcatttttg     9120

tcatccgcgg tcagccgcaa ttctgacgaa ctgcccattt agctggagat gattgtacat     9180

ccttcacgtg aaaatttctc aagcgctgtg aacaagggtt cagattttag attgaaaggt     9240

gagccgttga aacacgttct tcttgtcgat gacgacgtcg ctatgcggca tcttattatt     9300

gaatacctta cgatccacgc cttcaaagtg accgcggtag ccgacagcac ccagttcaca     9360

agagtactct cttccgcgac ggtcgatgtc gtggttgttg atctaaattt aggtcgtgaa     9420

gatgggctcg agatcgttcg taatctggcg gcaaagtctg atattccaat cataattatc     9480

agtggcgacc gccttgagga gacggataaa gttgttgcac tcgagctagg agcaagtgat     9540

tttatcgcta agccgttcag tatcagagag tttctagcac gcattcgggt tgccttgcgc     9600

gtgcgcccca acgttgtccg ctccaaagac cgacggtctt tttgttttac tgactggaca     9660

cttaatctca ggcaacgtcg cttgatgtcc gaagctggcg gtgaggtgaa acttacggca     9720

ggtgagttca atcttctcct cgcgttttta gagaaacccc gcgacgttct atcgcgcgag     9780

caacttctca ttgccagtcg agtacgcgac gaggaggttt atgacaggag tatagatgtt     9840

ctcattttga ggctgcgccg caaacttgag gcagatccgt caagccctca actgataaaa     9900

acagcaagag gtgccggtta tttctttgac gcggacgtgc aggtttcgca cggggggacg     9960

atggcagcct gagccaattc ccagatcccc gaggaatcgg cgtgagcggt cgcaaaccat    10020

ccggcccggt acaaatcggc gcggcgctgg gtgatgacct ggtggagaag ttgaaggccg    10080

cgcaggccgc ccagcggcaa cgcatcgagg cagaagcacg ccccggtgaa tcgtggcaag    10140

cggccgctga tcgaatccgc aaagaatccc ggcaaccgcc ggcagccggt gcgccgtcga    10200

ttaggaagcc gcccaagggc gacgagcaac cagatttttt cgttccgatg ctctatgacg    10260

tgggcacccg cgatagtcgc agcatcatgg acgtggccgt tttccgtctg tcgaagcgtg    10320

accgacgagc tggcgaggtg atccgctacg agcttccaga cgggcacgta gaggtttccg    10380

cagggccggc cggcatggcc agtgtgtggg attacgacct ggtactgatg gcggtttccc    10440

atctaaccga atccatgaac cgataccggg aagggaaggg agacaagccc ggccgcgtgt    10500

tccgtccaca cgttgcggac gtactcaagt tctgccggcg agccgatggc ggaaagcaga    10560

aagacgacct ggtagaaacc tgcattcggt taaacaccac gcacgttgcc atgcagcgta    10620

cgaagaaggc caagaacggc cgcctggtga cggtatccga gggtgaagcc ttgattagcc    10680

gctacaagat cgtaaagagc gaaaccgggc ggccggagta catcgagatc gagctagctg    10740

attggatgta ccgcgagatc acagaaggca agaacccgga cgtgctgacg gttcaccccg    10800

attacttttt gatcgatccc ggcatcggcc gttttctcta ccgcctggca cgccgcgccg    10860

caggcaaggc agaagccaga tggttgttca agacgatcta cgaacgcagt ggcagcgccg    10920

gagagttcaa gaagttctgt ttcaccgtgc gcaagctgat cgggtcaaat gacctgccgg    10980

agtacgattt gaaggaggag gcggggcagg ctggcccgat cctagtcatg cgctaccgca    11040

acctgatcga gggcgaagca tccgccggtt cctaatgtac ggagcagatg ctagggcaaa    11100

ttgccctagc aggggaaaaa ggtcgaaaag gtctctttcc tgtggatagc acgtacattg    11160

ggaacccaaa gccgtacatt gggaaccgga acccgtacat tgggaaccca aagccgtaca    11220

ttgggaaccg gtcacacatg taagtgactg atataaaaga gaaaaaaggc gatttttccg    11280

cctaaaactc tttaaaactt attaaaactc ttaaaacccg cctggcctgt gcataactgt    11340

ctggccagcg cacagccgaa gagctgcaaa aagcgcctac ccttcggtcg ctgcgctccc    11400

tacgccccgc cgcttcgcgt cggcctatcg cggccgctgg ccgctcaaaa atggctggcc    11460

tacggccagg caatctacca gggcgcggac aagccgcgcc gtcgccactc gaccgccggc    11520

gctgaggtct gcctcgtgaa gaaggtgttg ctgactcata ccaggcctga atcgccccat    11580

catccagcca gaaagtgagg gagccacggt tgatgagagc tttgttgtag gtggaccagt    11640

tggtgatttt gaacttttgc tttgccacgg aacggtctgc gttgtcggga agatgcgtga    11700

tctgatcctt caactcagca aaagttcgat ttattcaaca aagccgccgt cccgtcaagt    11760

cagcgtaatg ctctgccagt gttacaacca attaaccaat tctgattaga aaaactcatc    11820

gagcatcaaa tgaaactgca atttattcat atcaggatta tcaataccat atttttgaaa    11880

aagccgtttc tgtaatgaag gagaaaactc accgaggcag ttccatagga tggcaagatc    11940

ctggtatcgg tctgcgattc cgactcgtcc aacatcaata caacctatta atttcccctc    12000

gtcaaaaata aggttatcaa gtgagaaatc accatgagtg acgactgaat ccggtgagaa    12060

tggcaaaagc tctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg    12120

ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag    12180

cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag    12240

gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc    12300

tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc    12360

agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc    12420

tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt    12480

cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg    12540

ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat    12600

ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag    12660

ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt    12720

ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc    12780

cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta    12840

gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag    12900

atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga    12960

ttttggtcat gagattatca aaaaggatct tcacctagat ccttttgatc cggaattaat    13020

tcctgtggtt ggcatgcaca tacaaatgga cgaacggata aaccttttca cgccctttta    13080

aatatccgat tattctaata aacgctcttt tctcttaggt ttacccgcca atatatcctg    13140

tcaaacactg atagtttaaa ctgaaggcgg gaaacgacaa tctgatcatg agcggagaat    13200

taagggagtc acgttatgac ccccgccgat gacgcgggac aagccgtttt acgtttggaa    13260

ctgacagaac cgcaacgctg caggaattgg ccgcagcggc catttaaatc aattggg       13317


<210>  15
<211>  462
<212>  PRT
<213>  Bacillus thuringiensis

<400>  15

Met Lys Arg Met Glu Gly Lys Leu Phe Met Val Ser Thr Lys Leu Gln 
1               5                   10                  15      


Ala Val Thr Lys Ala Val Leu Leu Ser Thr Val Leu Ser Ile Ser Leu 
            20                  25                  30          


Leu Asn Asn Glu Val Ile Lys Ala Glu Gln Leu Asn Met Asn Ser Gln 
        35                  40                  45              


Asn Lys Tyr Thr Asn Phe Glu Asn Leu Lys Ile Thr Asp Lys Val Glu 
    50                  55                  60                  


Asp Phe Lys Glu Asp Lys Glu Lys Ala Lys Glu Trp Gly Lys Glu Lys 
65                  70                  75                  80  


Glu Lys Glu Trp Lys Leu Thr Ala Thr Glu Lys Gly Lys Met Asn Asn 
                85                  90                  95      


Phe Leu Asp Asn Lys Asn Asp Ile Lys Thr Asn Tyr Lys Glu Ile Thr 
            100                 105                 110         


Phe Ser Met Ala Gly Ser Phe Glu Asp Glu Ile Lys Asp Leu Lys Glu 
        115                 120                 125             


Ile Asp Lys Ile Phe Asp Lys Ala Asn Leu Ser Ser Pro Ile Ile Thr 
    130                 135                 140                 


Tyr Lys Asn Val Glu Pro Ala Thr Ile Gly Phe Asn Lys Ser Leu Thr 
145                 150                 155                 160 


Glu Gly Asn Thr Ile Asn Ser Asp Ala Met Ala Gln Phe Lys Glu Gln 
                165                 170                 175     


Phe Leu Asp Arg Asp Ile Lys Phe Asp Ser Tyr Leu Asp Thr His Leu 
            180                 185                 190         


Thr Val Gln Gln Val Ser Ser Lys Glu Arg Val Ile Leu Lys Val Lys 
        195                 200                 205             


Val Pro Ser Gly Lys Gly Ser Thr Thr Pro Thr Lys Ala Gly Ile Ile 
    210                 215                 220                 


Leu Asn Asn Ser Glu Tyr Lys Met Leu Ile Asp Asn Gly Tyr Met Val 
225                 230                 235                 240 


His Val Asp Lys Val Ser Lys Val Val Lys Lys Gly Val Glu Cys Leu 
                245                 250                 255     


Gln Val Glu Gly Thr Leu Lys Lys Ser Leu Asp Phe Lys Asn Asp Ile 
            260                 265                 270         


Asn Ala Gly Ala His Ser Trp Gly Met Lys Asn Tyr Glu Glu Trp Ala 
        275                 280                 285             


Lys Asp Leu Thr Asp Leu Gln Arg Glu Ala Leu Asp Gly Tyr Ala Arg 
    290                 295                 300                 


Gln Asp Tyr Lys Glu Ile Asn Asn Tyr Leu Arg Asn Gln Gly Gly Asn 
305                 310                 315                 320 


Gly Asn Glu Lys Leu Asp Ala Gln Ile Lys Asn Ile Ser Asp Ala Leu 
                325                 330                 335     


Gly Lys Lys Pro Ile Pro Glu Asn Ile Thr Val Tyr Arg Trp Cys Gly 
            340                 345                 350         


Met Pro Glu Phe Gly Tyr Gln Ile Ser Asp Pro Leu Pro Ser Leu Lys 
        355                 360                 365             


Asp Phe Glu Glu Gln Phe Leu Asn Thr Ile Lys Glu Asp Lys Gly Tyr 
    370                 375                 380                 


Met Ser Thr Ser Leu Ser Ser Glu Arg Leu Ala Ala Phe Gly Ser Arg 
385                 390                 395                 400 


Lys Ile Ile Leu Arg Leu Gln Val Pro Lys Gly Ser Thr Gly Ala Tyr 
                405                 410                 415     


Leu Ser Ala Ile Gly Gly Phe Ala Asn Glu Lys Glu Ile Leu Leu Asp 
            420                 425                 430         


Lys Asp Ser Lys Tyr His Ile Asp Lys Val Thr Glu Val Ile Ile Lys 
        435                 440                 445             


Gly Val Lys Arg Tyr Val Val Asp Ala Thr Leu Leu Thr Asn 
    450                 455                 460         


<210>  16
<211>  462
<212>  PRT
<213>  Bacillus thuringiensis

<400>  16

Met Gln Arg Met Glu Gly Lys Leu Phe Met Val Ser Lys Lys Leu Gln 
1               5                   10                  15      


Ala Val Thr Lys Thr Val Leu Leu Ser Thr Val Leu Ser Ile Ser Leu 
            20                  25                  30          


Leu Asn Asn Glu Glu Val Lys Ala Glu Gln Leu Asn Ile Asn Ser Gln 
        35                  40                  45              


Asn Lys Tyr Thr Asn Phe Gln Asn Leu Lys Ile Thr Asp Asn Ala Glu 
    50                  55                  60                  


Asp Phe Lys Glu Asp Lys Glu Lys Ala Lys Glu Trp Gly Glu Glu Lys 
65                  70                  75                  80  


Glu Lys Glu Trp Lys Leu Thr Ala Thr Glu Lys Gly Lys Met Asn Asn 
                85                  90                  95      


Phe Leu Asp Asn Lys Asn Asp Ile Lys Thr Asn Tyr Lys Glu Ile Thr 
            100                 105                 110         


Phe Ser Met Ala Gly Ser Phe Glu Asp Glu Ile Lys Asp Leu Lys Glu 
        115                 120                 125             


Ile Asp Lys Ile Phe Asp Lys Ala Asn Leu Ser Ser Ser Ile Ile Thr 
    130                 135                 140                 


Tyr Lys Asn Val Glu Pro Ala Thr Ile Gly Phe Asn Lys Ser Leu Thr 
145                 150                 155                 160 


Glu Gly Asn Thr Ile Asn Ser Asp Ala Met Ala Gln Phe Lys Glu Gln 
                165                 170                 175     


Phe Leu Gly Lys Asp Met Lys Phe Asp Ser Tyr Leu Asp Thr His Leu 
            180                 185                 190         


Thr Ala His Gln Val Ser Ser Lys Lys Arg Val Ile Leu Lys Val Thr 
        195                 200                 205             


Val Pro Ser Gly Lys Gly Ser Thr Thr Pro Thr Lys Ala Gly Val Ile 
    210                 215                 220                 


Leu Thr Asn Asn Glu Tyr Lys Met Leu Ile Asp Asn Gly Tyr Val Leu 
225                 230                 235                 240 


His Val Asp Lys Val Ser Lys Val Val Lys Lys Gly Met Glu Cys Leu 
                245                 250                 255     


Gln Val Glu Gly Thr Leu Lys Lys Ser Leu Asp Phe Lys Asn Asp Ile 
            260                 265                 270         


Asn Ala Glu Ala His Ser Trp Gly Met Lys Ile Tyr Glu Asp Trp Ala 
        275                 280                 285             


Lys Asn Leu Thr Ala Ser Gln Arg Glu Ala Leu Asp Gly Tyr Ala Arg 
    290                 295                 300                 


Gln Asp Tyr Lys Glu Ile Asn Asn Tyr Leu Arg Asn Gln Gly Gly Ser 
305                 310                 315                 320 


Gly Asn Glu Lys Leu Asp Ala Gln Ile Lys Asn Ile Ser Asp Ala Leu 
                325                 330                 335     


Gly Lys Lys Pro Ile Pro Glu Asn Ile Thr Val Tyr Arg Trp Cys Gly 
            340                 345                 350         


Met Pro Glu Phe Gly Tyr Gln Ile Ser Asp Pro Leu Pro Ser Leu Lys 
        355                 360                 365             


Asp Phe Glu Glu Gln Phe Leu Asn Thr Ile Lys Glu Asp Lys Gly Tyr 
    370                 375                 380                 


Met Ser Thr Ser Leu Ser Ser Glu Arg Leu Ala Ala Phe Gly Ser Arg 
385                 390                 395                 400 


Lys Ile Ile Leu Arg Leu Gln Val Pro Lys Gly Ser Thr Gly Ala Tyr 
                405                 410                 415     


Leu Ser Ala Ile Gly Gly Phe Ala Ser Glu Lys Glu Ile Leu Leu Asp 
            420                 425                 430         


Lys Asp Ser Lys Tyr His Ile Asp Lys Ala Thr Glu Val Ile Ile Lys 
        435                 440                 445             


Gly Val Lys Arg Tyr Val Val Asp Ala Thr Leu Leu Thr Asn 
    450                 455                 460         


<210>  17
<211>  462
<212>  PRT
<213>  Bacillus thuringiensis

<400>  17

Met Lys Arg Met Glu Gly Lys Leu Phe Met Val Ser Arg Lys Leu Gln 
1               5                   10                  15      


Leu Val Thr Lys Ala Leu Leu Phe Ser Thr Val Leu Ser Ile Pro Leu 
            20                  25                  30          


Leu Asn Asn Glu Glu Val Lys Ala Glu His Leu Asn Leu Asn Ser Gln 
        35                  40                  45              


Ser Lys Tyr Pro Ser Phe Gln Asn Gln Lys Ile Thr Asp Asn Ala Glu 
    50                  55                  60                  


Asp Phe Lys Glu Asp Lys Glu Lys Ala Lys Glu Trp Gly Glu Val Lys 
65                  70                  75                  80  


Glu Lys Glu Trp Lys Leu Thr Ala Thr Glu Lys Arg Lys Ile Asn Asp 
                85                  90                  95      


Phe Leu Asn Asp Thr Asn Lys Ile Lys Thr Asn Tyr Lys Glu Ile Thr 
            100                 105                 110         


Phe Ser Met Ala Gly Ser Phe Glu Asp Glu Leu Lys Asp Leu Lys Glu 
        115                 120                 125             


Ile Asp Lys Met Phe Asp Lys Ala Asn Leu Ser Ser Ser Ile Ile Thr 
    130                 135                 140                 


Tyr Lys Asn Val Glu Pro Ala Thr Ile Gly Phe Asn Lys Ser Leu Thr 
145                 150                 155                 160 


Glu Gly Asn Thr Ile Asn Ser Asp Val Met Ala Gln Phe Lys Glu Gln 
                165                 170                 175     


Phe Leu Gly Lys Asp Ile Lys Phe Asp Ser Tyr Leu Asp Thr His Leu 
            180                 185                 190         


Thr Val Gln Gln Val Ser Ser Lys Glu Arg Val Ile Leu Lys Val Thr 
        195                 200                 205             


Val Pro Ser Gly Lys Gly Ser Thr Asn Pro Thr Lys Ala Gly Val Ile 
    210                 215                 220                 


Leu Asp Gly Asn Glu Pro Lys Met Leu Ile Asp Asn Gly Tyr Val Leu 
225                 230                 235                 240 


His Val Asp Lys Val Ser Lys Val Val Lys Lys Gly Leu Glu Cys Leu 
                245                 250                 255     


Gln Val Glu Gly Thr Leu Lys Lys Ser Leu Asp Phe Lys Asn Asp Ile 
            260                 265                 270         


Ser Ala Lys Ala His Ser Trp Gly Met Lys Asn Tyr Glu Glu Trp Ala 
        275                 280                 285             


Ala Asn Leu Thr Asp Ser Gln Arg Lys Ala Leu Asp Gly Tyr Ala Arg 
    290                 295                 300                 


Gln Asp Tyr Lys Lys Ile Asn Asp Tyr Leu Arg Asn Gln Gly Gly Ser 
305                 310                 315                 320 


Gly Asn Glu Gln Leu Asp Ala Gln Ile Lys Asn Ile Ser Glu Thr Leu 
                325                 330                 335     


Asn Asn Lys Pro Ile Pro Glu Asn Ile Thr Val Tyr Arg Trp Cys Gly 
            340                 345                 350         


Met Pro Glu Phe Gly Tyr Gln Ile Ser Glu Pro Leu Pro Ala Leu Lys 
        355                 360                 365             


Asp Phe Glu Trp Glu Phe Leu Asn Thr Ile Lys Glu Asp Lys Gly Tyr 
    370                 375                 380                 


Ile Ser Thr Ser Leu Ser Ser Glu Arg Leu Ala Ala Phe Gly Ser Arg 
385                 390                 395                 400 


Lys Ile Ile Leu Arg Leu Gln Ile Pro Lys Gly Ser Lys Gly Ala Tyr 
                405                 410                 415     


Leu Ser Ala Ile Gly Gly Phe Ala Asn Glu Lys Glu Ile Leu Leu Asp 
            420                 425                 430         


Lys Asp Ser Lys Tyr His Ile Asn Lys Ile Thr Glu Val Val Ile Lys 
        435                 440                 445             


Gly Ile Lys Arg Tyr Val Val Asp Ala Thr Leu Leu Thr Asn 
    450                 455                 460         


<210>  18
<211>  457
<212>  PRT
<213>  Bacillus thuringiensis

<400>  18

Met Ile Val Ile Ile Phe Thr Asn Val Lys Gly Gly Asn Glu Leu Lys 
1               5                   10                  15      


Lys Asn Phe Tyr Lys Asn Leu Ile Cys Met Ser Ala Leu Leu Leu Ala 
            20                  25                  30          


Met Pro Ile Ser Ser Asn Val Thr Tyr Ala Tyr Gly Ser Glu Lys Val 
        35                  40                  45              


Asp Tyr Leu Val Lys Thr Thr Asn Asn Thr Glu Asp Phe Lys Glu Asp 
    50                  55                  60                  


Lys Glu Lys Ala Lys Glu Trp Gly Lys Glu Lys Glu Lys Glu Trp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Glu Lys Thr Arg Met Asn Asn Phe Leu Asp Asn Lys 
                85                  90                  95      


Asn Asp Ile Lys Lys Asn Tyr Lys Glu Ile Thr Phe Ser Met Ala Gly 
            100                 105                 110         


Ser Phe Glu Asp Glu Ile Lys Asp Leu Lys Glu Ile Asp Lys Met Phe 
        115                 120                 125             


Asp Lys Ala Asn Leu Ser Ser Ser Ile Val Thr Tyr Lys Asn Val Glu 
    130                 135                 140                 


Pro Ser Thr Ile Gly Phe Asn Lys Pro Leu Thr Glu Gly Asn Thr Ile 
145                 150                 155                 160 


Asn Thr Asp Val Gln Ala Gln Phe Lys Glu Gln Phe Leu Gly Lys Asp 
                165                 170                 175     


Ile Lys Phe Asp Ser Tyr Leu Asp Thr His Leu Thr Ala Gln Asn Val 
            180                 185                 190         


Ser Ser Lys Glu Arg Ile Ile Leu Gln Val Thr Val Pro Ser Gly Lys 
        195                 200                 205             


Gly Ser Thr Ile Pro Thr Lys Ala Gly Val Ile Leu Asn Asn Asn Glu 
    210                 215                 220                 


Tyr Lys Met Leu Ile Asp Asn Gly Tyr Val Leu His Val Asp Asn Ile 
225                 230                 235                 240 


Ser Lys Val Val Lys Lys Gly Tyr Glu Cys Leu Gln Ile Gln Gly Thr 
                245                 250                 255     


Leu Lys Lys Ser Leu Asp Phe Lys Asn Asp Ile Asn Ala Glu Ala His 
            260                 265                 270         


Arg Trp Gly Met Lys Asn Tyr Glu Gly Trp Ala Lys Asn Leu Thr Asp 
        275                 280                 285             


Pro Gln Arg Glu Ala Leu Asp Gly Tyr Ala Arg Gln Asp Tyr Lys Gln 
    290                 295                 300                 


Ile Asn Asp Tyr Leu Arg Asn Gln Gly Gly Ser Gly Asn Glu Lys Leu 
305                 310                 315                 320 


Asp Thr Gln Ile Lys Asn Ile Ser Glu Ala Leu Glu Lys Gln Pro Ile 
                325                 330                 335     


Pro Glu Asn Ile Thr Val Tyr Arg Trp Cys Gly Met Ala Glu Phe Gly 
            340                 345                 350         


Tyr Gln Ile Ser Asp Pro Leu Pro Ser Leu Lys Glu Met Glu Glu Lys 
        355                 360                 365             


Phe Leu Asn Thr Met Lys Glu Asp Lys Gly Tyr Met Ser Thr Ser Leu 
    370                 375                 380                 


Ser Ser Glu Arg Leu Ser Ala Phe Gly Ser Arg Lys Phe Ile Leu Arg 
385                 390                 395                 400 


Leu Gln Val Pro Lys Gly Ser Thr Gly Ala Tyr Leu Ser Ala Ile Gly 
                405                 410                 415     


Gly Phe Ala Ser Glu Lys Glu Ile Leu Ile Asp Lys Asp Ser Asn Tyr 
            420                 425                 430         


His Ile Asp Lys Ile Thr Glu Val Val Ile Lys Gly Val Lys Arg Tyr 
        435                 440                 445             


Val Val Asp Ala Thr Leu Leu Thr Lys 
    450                 455         


<210>  19
<211>  460
<212>  PRT
<213>  Bacillus thuringiensis

<400>  19

Met Lys Arg Met Glu Glu Arg Leu Phe Met Val Ser Lys Lys Leu Gln 
1               5                   10                  15      


Leu Ile Thr Lys Thr Leu Val Phe Ser Thr Val Leu Ser Ile Pro Leu 
            20                  25                  30          


Leu Asn Asn Ser Glu Ile Lys Ala Glu Gln Leu Asn Met Asn Ser Gln 
        35                  40                  45              


Ile Lys Tyr Pro Asn Phe Gln Asn Ile Asn Ile Ala Asp Lys Pro Val 
    50                  55                  60                  


Asp Phe Lys Glu Asp Lys Glu Lys Ala Arg Glu Trp Gly Lys Glu Lys 
65                  70                  75                  80  


Glu Lys Glu Trp Lys Leu Thr Ala Thr Glu Lys Gly Lys Ile Asn Asp 
                85                  90                  95      


Phe Leu Asp Asp Lys Asp Gly Leu Lys Thr Lys Tyr Lys Glu Ile Asn 
            100                 105                 110         


Phe Ser Lys Asn Phe Glu Tyr Glu Thr Glu Leu Lys Glu Leu Glu Lys 
        115                 120                 125             


Ile Asn Thr Met Leu Asp Lys Ala Asn Leu Thr Asn Ser Ile Val Thr 
    130                 135                 140                 


Tyr Lys Asn Val Glu Pro Thr Thr Ile Gly Phe Asn Gln Ser Leu Ile 
145                 150                 155                 160 


Glu Gly Asn Gln Ile Asn Ala Glu Ala Gln Gln Lys Phe Lys Glu Gln 
                165                 170                 175     


Phe Leu Gly Gln Asp Ile Lys Phe Asp Ser Tyr Leu Asp Met His Leu 
            180                 185                 190         


Thr Glu Gln Asn Val Ser Ser Lys Glu Arg Val Ile Leu Lys Val Thr 
        195                 200                 205             


Val Pro Ser Gly Lys Gly Ser Thr Pro Thr Lys Ala Gly Val Val Leu 
    210                 215                 220                 


Asn Asn Asn Glu Tyr Lys Met Leu Ile Asp Asn Gly Tyr Val Leu His 
225                 230                 235                 240 


Val Glu Asn Ile Thr Lys Val Val Lys Lys Gly Gln Glu Cys Leu Gln 
                245                 250                 255     


Val Glu Gly Thr Leu Lys Lys Ser Leu Asp Phe Lys Asn Asp Ser Asp 
            260                 265                 270         


Gly Lys Gly Asp Ser Trp Gly Lys Lys Asn Tyr Lys Glu Trp Ser Asp 
        275                 280                 285             


Thr Leu Thr Thr Asp Gln Arg Lys Asp Leu Asn Asp Tyr Gly Ala Arg 
    290                 295                 300                 


Gly Tyr Thr Glu Ile Asn Lys Tyr Leu Arg Glu Gly Gly Thr Gly Asn 
305                 310                 315                 320 


Thr Glu Leu Glu Glu Lys Ile Lys Asn Ile Ser Asp Ala Leu Glu Lys 
                325                 330                 335     


Asn Pro Ile Pro Glu Asn Ile Thr Val Tyr Arg Tyr Cys Gly Met Ala 
            340                 345                 350         


Glu Phe Gly Tyr Pro Ile Lys Pro Glu Ala Pro Ser Val Gln Asp Phe 
        355                 360                 365             


Glu Glu Arg Phe Leu Asp Thr Ile Lys Glu Glu Lys Gly Tyr Met Ser 
    370                 375                 380                 


Thr Ser Leu Ser Ser Asp Ala Thr Ser Phe Gly Ala Arg Lys Ile Ile 
385                 390                 395                 400 


Leu Arg Leu Gln Val Pro Lys Gly Ser Ser Gly Ala Tyr Val Ala Gly 
                405                 410                 415     


Leu Asp Gly Phe Lys Pro Ala Glu Lys Glu Ile Leu Ile Asp Lys Gly 
            420                 425                 430         


Ser Lys Tyr Arg Ile Asp Lys Val Thr Glu Val Val Val Lys Gly Thr 
        435                 440                 445             


Arg Lys Leu Val Val Asp Ala Thr Leu Leu Thr Lys 
    450                 455                 460 


<210>  20
<211>  463
<212>  PRT
<213>  Clostrium difficile

<400>  20

Met Lys Lys Phe Arg Lys His Lys Arg Ile Ser Asn Cys Ile Ser Ile 
1               5                   10                  15      


Leu Leu Ile Leu Tyr Leu Thr Leu Gly Gly Leu Leu Pro Asn Asn Ile 
            20                  25                  30          


Tyr Ala Gln Asp Leu Gln Ser Tyr Ser Glu Lys Val Cys Asn Thr Thr 
        35                  40                  45              


Tyr Lys Ala Pro Ile Glu Arg Pro Glu Asp Phe Leu Lys Asp Lys Glu 
    50                  55                  60                  


Lys Ala Lys Glu Trp Glu Arg Lys Glu Ala Glu Arg Ile Glu Gln Lys 
65                  70                  75                  80  


Leu Glu Arg Ser Glu Lys Glu Ala Leu Glu Ser Tyr Lys Lys Asp Ser 
                85                  90                  95      


Val Glu Ile Ser Lys Tyr Ser Gln Thr Arg Asn Tyr Phe Tyr Asp Tyr 
            100                 105                 110         


Gln Ile Glu Ala Asn Ser Arg Glu Lys Glu Tyr Lys Glu Leu Arg Asn 
        115                 120                 125             


Ala Ile Ser Lys Asn Lys Ile Asp Lys Pro Met Tyr Val Tyr Tyr Phe 
    130                 135                 140                 


Glu Ser Pro Glu Lys Phe Ala Phe Asn Lys Val Ile Arg Thr Glu Asn 
145                 150                 155                 160 


Gln Asn Glu Ile Ser Leu Glu Lys Phe Asn Glu Phe Lys Glu Thr Ile 
                165                 170                 175     


Gln Asn Lys Leu Phe Lys Gln Asp Gly Phe Lys Asp Ile Ser Leu Tyr 
            180                 185                 190         


Glu Pro Gly Lys Gly Asp Glu Lys Pro Thr Pro Leu Leu Met His Leu 
        195                 200                 205             


Lys Leu Pro Arg Asn Thr Gly Met Leu Pro Tyr Thr Asn Thr Asn Asn 
    210                 215                 220                 


Val Ser Thr Leu Ile Glu Gln Gly Tyr Ser Ile Lys Ile Asp Lys Ile 
225                 230                 235                 240 


Val Arg Ile Val Ile Asp Gly Lys His Tyr Ile Lys Ala Glu Ala Ser 
                245                 250                 255     


Val Val Ser Ser Leu Asp Phe Lys Asp Asp Val Ser Lys Gly Asp Ser 
            260                 265                 270         


Trp Gly Lys Ala Asn Tyr Asn Asp Trp Ser Asn Lys Leu Thr Pro Asn 
        275                 280                 285             


Glu Leu Ala Asp Val Asn Asp Tyr Met Arg Gly Gly Tyr Thr Ala Ile 
    290                 295                 300                 


Asn Asn Tyr Leu Ile Ser Asn Gly Pro Val Asn Asn Pro Asn Pro Glu 
305                 310                 315                 320 


Leu Asp Ser Lys Ile Thr Asn Ile Glu Asn Ala Leu Lys Arg Glu Pro 
                325                 330                 335     


Ile Pro Thr Asn Leu Thr Val Tyr Arg Arg Ser Gly Pro Gln Glu Phe 
            340                 345                 350         


Gly Leu Thr Leu Thr Ser Pro Glu Tyr Asp Phe Asn Lys Leu Glu Asn 
        355                 360                 365             


Ile Asp Ala Phe Lys Ser Lys Trp Glu Gly Gln Ala Leu Ser Tyr Pro 
    370                 375                 380                 


Asn Phe Ile Ser Thr Ser Ile Gly Ser Val Asn Met Ser Ala Phe Ala 
385                 390                 395                 400 


Lys Arg Lys Ile Val Leu Arg Ile Thr Ile Pro Lys Gly Ser Pro Gly 
                405                 410                 415     


Ala Tyr Leu Ser Ala Ile Pro Gly Tyr Ala Gly Glu Tyr Glu Val Leu 
            420                 425                 430         


Leu Asn His Gly Ser Lys Phe Lys Ile Asn Lys Ile Asp Ser Tyr Lys 
        435                 440                 445             


Asp Gly Thr Ile Thr Lys Leu Ile Val Asp Ala Thr Leu Ile Pro 
    450                 455                 460             


<210>  21
<211>  454
<212>  PRT
<213>  Clostridium perfringens

<400>  21

Met Lys Lys Val Asn Lys Ser Ile Ser Val Phe Leu Ile Leu Tyr Leu 
1               5                   10                  15      


Ile Leu Thr Ser Ser Phe Pro Ser Tyr Thr Tyr Ala Gln Asp Leu Gln 
            20                  25                  30          


Ile Ala Ser Asn Tyr Ile Thr Asp Arg Ala Phe Ile Glu Arg Pro Glu 
        35                  40                  45              


Asp Phe Leu Lys Asp Lys Glu Asn Ala Ile Gln Trp Glu Lys Lys Glu 
    50                  55                  60                  


Ala Glu Arg Val Glu Lys Asn Leu Asp Thr Leu Glu Lys Glu Ala Leu 
65                  70                  75                  80  


Glu Leu Tyr Lys Lys Asp Ser Glu Gln Ile Ser Asn Tyr Ser Gln Thr 
                85                  90                  95      


Arg Gln Tyr Phe Tyr Asp Tyr Gln Ile Glu Ser Asn Pro Arg Glu Lys 
            100                 105                 110         


Glu Tyr Lys Asn Leu Arg Asn Ala Ile Ser Lys Asn Lys Ile Asp Lys 
        115                 120                 125             


Pro Ile Asn Val Tyr Tyr Phe Glu Ser Pro Glu Lys Phe Ala Phe Asn 
    130                 135                 140                 


Lys Glu Ile Arg Thr Glu Asn Gln Asn Glu Ile Ser Leu Glu Lys Phe 
145                 150                 155                 160 


Asn Glu Leu Lys Glu Thr Ile Gln Asp Lys Leu Phe Lys Gln Asp Gly 
                165                 170                 175     


Phe Lys Asp Val Ser Leu Tyr Glu Pro Gly Asn Gly Asp Glu Lys Pro 
            180                 185                 190         


Thr Pro Leu Leu Ile His Leu Lys Leu Pro Lys Asn Thr Gly Met Leu 
        195                 200                 205             


Pro Tyr Ile Asn Ser Asn Asp Val Lys Thr Leu Ile Glu Gln Asp Tyr 
    210                 215                 220                 


Ser Ile Lys Ile Asp Lys Ile Val Arg Ile Val Ile Glu Gly Lys Gln 
225                 230                 235                 240 


Tyr Ile Lys Ala Glu Ala Ser Ile Val Asn Ser Leu Asp Phe Lys Asp 
                245                 250                 255     


Asp Val Ser Lys Gly Asp Leu Trp Gly Lys Glu Asn Tyr Ser Asp Trp 
            260                 265                 270         


Ser Asn Lys Leu Thr Pro Asn Glu Leu Ala Asp Val Asn Asp Tyr Met 
        275                 280                 285             


Arg Gly Gly Tyr Thr Ala Ile Asn Asn Tyr Leu Ile Ser Asn Gly Pro 
    290                 295                 300                 


Leu Asn Asn Pro Asn Pro Glu Leu Asp Ser Lys Val Asn Asn Ile Glu 
305                 310                 315                 320 


Asn Ala Leu Lys Leu Thr Pro Ile Pro Ser Asn Leu Ile Val Tyr Arg 
                325                 330                 335     


Arg Ser Gly Pro Gln Glu Phe Gly Leu Thr Leu Thr Ser Pro Glu Tyr 
            340                 345                 350         


Asp Phe Asn Lys Ile Glu Asn Ile Asp Ala Phe Lys Glu Lys Trp Glu 
        355                 360                 365             


Gly Lys Val Ile Thr Tyr Pro Asn Phe Ile Ser Thr Ser Ile Gly Ser 
    370                 375                 380                 


Val Asn Met Ser Ala Phe Ala Lys Arg Lys Ile Ile Leu Arg Ile Asn 
385                 390                 395                 400 


Ile Pro Lys Asp Ser Pro Gly Ala Tyr Leu Ser Ala Ile Pro Gly Tyr 
                405                 410                 415     


Ala Gly Glu Tyr Glu Val Leu Leu Asn His Gly Ser Lys Phe Lys Ile 
            420                 425                 430         


Asn Lys Val Asp Ser Tyr Lys Asp Gly Thr Val Thr Lys Leu Ile Leu 
        435                 440                 445             


Asp Ala Thr Leu Ile Asn 
    450                 


<210>  22
<211>  459
<212>  PRT
<213>  Clostridium spiroforme

<400>  22

Met Lys Lys Tyr Lys Asn Asn Cys Ile Ser Ile Leu Leu Met Leu Phe 
1               5                   10                  15      


Leu Ile Leu Thr Gly Leu Phe Pro Asn Thr Val Phe Ala Gln Gly Ala 
            20                  25                  30          


Gln Ser Tyr Asp Phe Arg Thr Ile Asn Asn Ile Ala Asn Tyr Ser Ala 
        35                  40                  45              


Ile Glu Arg Pro Glu Asp Phe Leu Lys Asp Lys Glu Lys Ala Lys Asp 
    50                  55                  60                  


Trp Glu Arg Lys Glu Ala Glu Arg Ile Glu Lys Asn Leu Glu Lys Ser 
65                  70                  75                  80  


Glu Arg Glu Ala Leu Glu Ser Tyr Lys Lys Asp Ala Val Glu Ile Ser 
                85                  90                  95      


Lys Tyr Ser Gln Val Arg Asn Tyr Phe Tyr Asp Tyr Pro Ile Glu Ala 
            100                 105                 110         


Asn Thr Arg Glu Lys Glu Tyr Lys Glu Leu Lys Asn Ala Val Ser Lys 
        115                 120                 125             


Asn Lys Ile Asp Lys Pro Met Tyr Val Tyr Tyr Phe Glu Ser Pro Glu 
    130                 135                 140                 


Lys Phe Ala Phe Asn Lys Glu Ile Arg Ala Glu Ser Gln Asn Glu Ile 
145                 150                 155                 160 


Ser Leu Glu Arg Phe Asn Glu Phe Lys Ala Thr Ile Gln Asp Lys Leu 
                165                 170                 175     


Phe Lys Gln Asp Gly Phe Lys Asp Ile Ser Leu Tyr Glu Pro Gly Asn 
            180                 185                 190         


Gly Asp Lys Lys Ser Thr Pro Leu Leu Ile His Leu Lys Leu Pro Lys 
        195                 200                 205             


Asp Thr Gly Met Leu Pro Tyr Ser Asn Ser Asn Asp Val Ser Thr Leu 
    210                 215                 220                 


Ile Glu Gln Gly Tyr Ser Ile Lys Ile Asp Lys Ile Val Arg Ile Val 
225                 230                 235                 240 


Leu Glu Gly Lys Gln Tyr Ile Lys Ala Glu Ala Ser Val Val Ser Cys 
                245                 250                 255     


Leu Asp Phe Lys Asp Asp Val Ser Lys Gly Asp Ser Trp Gly Lys Ala 
            260                 265                 270         


Asn Tyr Ser Asp Trp Ser Asn Lys Leu Ser Ser Asp Glu Leu Ala Gly 
        275                 280                 285             


Val Asn Asp Tyr Met Arg Gly Arg Tyr Thr Ala Ile Asn Asn Tyr Leu 
    290                 295                 300                 


Ile Ala Asn Gly Pro Thr Asn Asn Pro Asn Ala Glu Leu Asp Ala Lys 
305                 310                 315                 320 


Ile Asn Asn Ile Glu Asn Ala Leu Lys Arg Glu Pro Ile Pro Ala Asn 
                325                 330                 335     


Leu Val Val Tyr Arg Arg Ser Gly Pro Gln Glu Phe Gly Leu Thr Leu 
            340                 345                 350         


Ser Ser Pro Glu Tyr Asp Phe Asn Lys Val Glu Asn Ile Asp Ala Phe 
        355                 360                 365             


Lys Glu Lys Trp Glu Gly Gln Thr Leu Ser Tyr Pro Asn Phe Val Ser 
    370                 375                 380                 


Thr Ser Ile Gly Ser Val Asn Met Ser Ala Phe Ala Lys Arg Lys Ile 
385                 390                 395                 400 


Val Leu Arg Ile Ser Ile Pro Lys Asn Ser Pro Gly Ala Tyr Leu Ser 
                405                 410                 415     


Ala Ile Pro Gly Tyr Ala Gly Glu Tyr Glu Val Leu Leu Asn His Gly 
            420                 425                 430         


Ser Lys Phe Lys Ile Ser Lys Ile Asp Ser Tyr Lys Asp Gly Thr Thr 
        435                 440                 445             


Thr Lys Leu Ile Val Asp Arg Thr Leu Ile Asp 
    450                 455                 


<210>  23
<211>  431
<212>  PRT
<213>  Clostridium botulinum

<400>  23

Met Pro Ile Ile Lys Glu Pro Ile Asp Phe Ile Asn Lys Pro Glu Ser 
1               5                   10                  15      


Glu Ala Gln Lys Trp Gly Lys Glu Glu Glu Lys Arg Trp Phe Thr Lys 
            20                  25                  30          


Leu Asn Asn Leu Glu Glu Val Ala Val Asn Gln Leu Lys Thr Lys Glu 
        35                  40                  45              


Asp Lys Thr Lys Ile Asp Asn Phe Ser Thr Asp Ile Leu Phe Ser Ser 
    50                  55                  60                  


Leu Thr Ala Ile Glu Ile Met Lys Glu Asp Glu Asn Gln Asn Leu Phe 
65                  70                  75                  80  


Asp Val Glu Arg Ile Arg Glu Ala Leu Leu Lys Asn Thr Leu Asp Arg 
                85                  90                  95      


Glu Val Ile Gly Tyr Val Asn Phe Thr Pro Lys Glu Leu Gly Ile Asn 
            100                 105                 110         


Phe Ser Ile Arg Asp Val Glu Leu Asn Arg Asp Ile Ser Asp Glu Ile 
        115                 120                 125             


Leu Asp Lys Val Arg Gln Gln Ile Ile Asn Gln Glu Tyr Thr Lys Phe 
    130                 135                 140                 


Ser Phe Val Ser Leu Gly Leu Asn Asp Asn Ser Ile Asp Glu Ser Ile 
145                 150                 155                 160 


Pro Val Ile Val Lys Thr Arg Val Pro Thr Thr Phe Asn Tyr Gly Val 
                165                 170                 175     


Leu Asn Asn Lys Glu Thr Val Ser Leu Leu Leu Asn Gln Gly Phe Ser 
            180                 185                 190         


Ile Ile Pro Glu Ser Ala Ile Ile Thr Thr Ile Lys Gly Lys Asp Tyr 
        195                 200                 205             


Ile Leu Ile Glu Gly Ser Leu Ser Gln Glu Leu Asp Phe Tyr Asn Lys 
    210                 215                 220                 


Gly Ser Glu Ala Trp Gly Glu Lys Asn Tyr Gly Asp Tyr Val Ser Lys 
225                 230                 235                 240 


Leu Ser Gln Glu Gln Leu Gly Ala Leu Glu Gly Tyr Leu His Ser Asp 
                245                 250                 255     


Tyr Lys Ala Ile Asn Ser Tyr Leu Arg Asn Asn Arg Val Pro Asn Asn 
            260                 265                 270         


Asp Glu Leu Asn Lys Lys Ile Glu Leu Ile Ser Ser Ala Leu Ser Val 
        275                 280                 285             


Lys Pro Ile Pro Glu Thr Leu Ile Ala Tyr Arg Arg Val Asp Gly Ile 
    290                 295                 300                 


Pro Phe Asp Leu Pro Ser Asp Phe Ser Phe Asp Lys Lys Glu Asn Gly 
305                 310                 315                 320 


Glu Ile Ile Ala Asp Lys Thr Lys Leu Asn Glu Phe Ile Asp Lys Trp 
                325                 330                 335     


Thr Gly Lys Glu Ile Glu Asn Leu Ser Phe Ser Ser Thr Ser Leu Lys 
            340                 345                 350         


Ser Thr Pro Leu Ser Phe Ser Lys Ser Arg Phe Ile Phe Arg Leu Arg 
        355                 360                 365             


Leu Ser Glu Gly Thr Ile Gly Ala Phe Ile Tyr Gly Phe Ser Gly Phe 
    370                 375                 380                 


Gln Asp Glu Gln Glu Ile Leu Leu Asn Lys Asn Ser Thr Phe Lys Ile 
385                 390                 395                 400 


Phe Arg Ile Thr Pro Ile Thr Ser Ile Ile Asn Arg Val Thr Lys Met 
                405                 410                 415     


Thr Gln Val Val Ile Asp Ala Glu Val Ile Gln Asn Lys Glu Ile 
            420                 425                 430     


