
                                SEQUENCE LISTING

<110> Halo-Bio RNAi Therapeutics Inc.
      Hauser, Todd

<120> COMPOSITIONS AND METHODS FOR MODULATING
  GENE EXPRESSION USING ASYMMETRICALLY-ACTIVE PRECURSOR
  POLYNUCLEOTIDES

<130> 430157.402PC

<140> PCT                 
<141> 2008-12-08  

<160> 38

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Design part for assymetric siRNA molecule

<220> 
<221> misc_feature   
<222> 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17,
18, 19, 20, 21, 22
<223> n = A,T,C,G or U

<400> 1
nnnnnnnnnn nnnnnnnnnn nn                                          22

<210> 2
<211> 34
<212> RNA
<213> Artificial Sequence

<220> 
<223> Design part for assymetric siRNA molecule - 5'
      stem loop

<400> 2
guagguggca uuucagaaga gaugccaccu acaa                             34

<210> 3
<211> 34
<212> RNA
<213> Artificial Sequence

<220> 
<223> Design part for assymetric siRNA molecule - 3'
      stem loop

<400> 3
ucuauucgac cuucagaaga gggucgaaua gaaa                             34

<210> 4
<211> 16
<212> RNA
<213> Artificial Sequence

<220> 
<223> Design part for assymetric shRNA molecule - shRNA
      stem loop

<400> 4
uugcgcgugg uagcaa                                                 16

<210> 5
<211> 112
<212> RNA
<213> Artificial Sequence

<220> 
<223> Assymetric siRNA molecule

<220> 
<221> misc_feature   
<222> 1, 2, 3, 4, 5, 6, 7, 8, 9, 46, 47, 48, 49, 50, 51, 52, 53,
54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,
104, 105, 106, 107, 108, 109, 110, 111, 112
<223> n = A,U,C or G

<400> 5
nnnnnnnnnu uucuauucga ccuucagaag agggucgaau agaaannnnn nnnnnnnnnn 60
nnnnnnnuug uagguggcau uucagaagag augccaccua caannnnnnn nn         112

<210> 6
<211> 92
<212> RNA
<213> Artificial Sequence

<220> 
<223> Assymetric shRNA molecule

<220> 
<221> misc_feature   
<222> 1, 2, 3, 4, 5, 6, 7, 8, 9, 26, 27, 28, 29, 30, 31, 32, 33,
34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47,
84, 85, 86, 87, 88, 89, 90, 91, 92
<223> n = A,U,C or G

<400> 6
nnnnnnnnnu ugcgcguggu agcaannnnn nnnnnnnnnn nnnnnnnuug uagguggcau 60
uucagaagag augccaccua caannnnnnn nn                               92

<210> 7
<211> 62
<212> DNA
<213> Artificial Sequence

<220> 
<223> Positive control shRNA sequence

<400> 7
gatccccgca agctgaccct gaagttcttc aagagagaac ttcagggtca gcttgctttt 60
ta                                                                62

<210> 8
<211> 62
<212> DNA
<213> Artificial Sequence

<220> 
<223> Positive control shRNA sequence

<400> 8
agcttaaaaa gcaagctgac cctgaagttc tctcttgaag aacttcaggg tcagcttgcg 60
gg                                                                62

<210> 9
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> Negative control shRNA sequence

<400> 9
gatccccgcg cgctttgtag gattcgttca agagacgaat cctacaaagc gcgcttttta 60


<210> 10
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> Negative control shRNA sequence

<400> 10
agcttaaaaa gcgcgctttg taggattcgt ctcttgaacg aatcctacaa agcgcgcggg 60


<210> 11
<211> 721
<212> DNA
<213> Artificial Sequence

<220> 
<223> EGFP sequence obtained from pIRES-EGFP vector

<400> 11
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac 60
ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac 120
ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc 180
ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag 240
cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc 300
ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg 360
gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac 420
aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac 480
ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc 540
gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac 600
tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc 660
ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa 720
a                                                                 721

<210> 12
<211> 721
<212> RNA
<213> Artificial Sequence

<220> 
<223> RNA transcript of EGFP sequence obtained from
      pIRES-EGFP vector

<400> 12
auggugagca agggcgagga gcuguucacc gggguggugc ccauccuggu cgagcuggac 60
ggcgacguaa acggccacaa guucagcgug uccggcgagg gcgagggcga ugccaccuac 120
ggcaagcuga cccugaaguu caucugcacc accggcaagc ugcccgugcc cuggcccacc 180
cucgugacca cccugaccua cggcgugcag ugcuucagcc gcuaccccga ccacaugaag 240
cagcacgacu ucuucaaguc cgccaugccc gaaggcuacg uccaggagcg caccaucuuc 300
uucaaggacg acggcaacua caagacccgc gccgagguga aguucgaggg cgacacccug 360
gugaaccgca ucgagcugaa gggcaucgac uucaaggagg acggcaacau ccuggggcac 420
aagcuggagu acaacuacaa cagccacaac gucuauauca uggccgacaa gcagaagaac 480
ggcaucaagg ugaacuucaa gauccgccac aacaucgagg acggcagcgu gcagcucgcc 540
gaccacuacc agcagaacac ccccaucggc gacggccccg ugcugcugcc cgacaaccac 600
uaccugagca cccaguccgc ccugagcaaa gaccccaacg agaagcgcga ucacaugguc 660
cugcuggagu ucgugaccgc cgccgggauc acucucggca uggacgagcu guacaaguaa 720
a                                                                 721

<210> 13
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Anti-GFP target sequence

<400> 13
gcaagctgac cctgaagttc at                                          22

<210> 14
<211> 112
<212> RNA
<213> Artificial Sequence

<220> 
<223> GFP assymetric siRNA molecule

<400> 14
gaaguucauu uucuauucga ccuucagaag agggucgaau agaaaaugaa cuucaggguc 60
agcuugcuug uagguggcau uucagaagag augccaccua caagcaagcu ga         112

<210> 15
<211> 92
<212> RNA
<213> Artificial Sequence

<220> 
<223> GFP assymetric shRNA molecule

<400> 15
gaaguucauu ugcgcguggu agcaaaugaa cuucaggguc agcuugcuug uagguggcau 60
uucagaagag augccaccua caagcaagcu ga                               92

<210> 16
<211> 1653
<212> RNA
<213> Artificial Sequence

<220> 
<223> Luciferase sequence from cloning vector pGL3

<400> 16
auggaagacg ccaaaaacau aaagaaaggc ccggcgccau ucuauccgcu ggaagaugga 60
accgcuggag agcaacugca uaaggcuaug aagagauacg cccugguucc uggaacaauu 120
gcuuuuacag augcacauau cgagguggac aucacuuacg cugaguacuu cgaaaugucc 180
guucgguugg cagaagcuau gaaacgauau gggcugaaua caaaucacag aaucgucgua 240
ugcagugaaa acucucuuca auucuuuaug ccgguguugg gcgcguuauu uaucggaguu 300
gcaguugcgc ccgcgaacga cauuuauaau gaacgugaau ugcucaacag uaugggcauu 360
ucgcagccua ccgugguguu cguuuccaaa aagggguugc aaaaaauuuu gaacgugcaa 420
aaaaagcucc caaucaucca aaaaauuauu aucauggauu cuaaaacgga uuaccaggga 480
uuucagucga uguacacguu cgucacaucu caucuaccuc ccgguuuuaa ugaauacgau 540
uuugugccag aguccuucga uagggacaag acaauugcac ugaucaugaa cuccucugga 600
ucuacugguc ugccuaaagg ugucgcucug ccucauagaa cugccugcgu gagauucucg 660
caugccagag auccuauuuu uggcaaucaa aucauuccgg auacugcgau uuuaaguguu 720
guuccauucc aucacgguuu uggaauguuu acuacacucg gauauuugau auguggauuu 780
cgagucgucu uaauguauag auuugaagaa gagcuguuuc ugaggagccu ucaggauuac 840
aagauucaaa gugcgcugcu ggugccaacc cuauucuccu ucuucgccaa aagcacucug 900
auugacaaau acgauuuauc uaauuuacac gaaauugcuu cugguggcgc uccccucucu 960
aaggaagucg gggaagcggu ugccaagagg uuccaucugc cagguaucag gcaaggauau 1020
gggcucacug agacuacauc agcuauucug auuacacccg agggggauga uaaaccgggc 1080
gcggucggua aaguuguucc auuuuuugaa gcgaagguug uggaucugga uaccgggaaa 1140
acgcugggcg uuaaucaaag aggcgaacug ugugugagag guccuaugau uauguccggu 1200
uauguaaaca auccggaagc gaccaacgcc uugauugaca aggauggaug gcuacauucu 1260
ggagacauag cuuacuggga cgaagacgaa cacuucuuca ucguugaccg ccugaagucu 1320
cugauuaagu acaaaggcua ucagguggcu cccgcugaau uggaauccau cuugcuccaa 1380
caccccaaca ucuucgacgc aggugucgca ggucuucccg acgaugacgc cggugaacuu 1440
cccgccgccg uuguuguuuu ggagcacgga aagacgauga cggaaaaaga gaucguggau 1500
uacgucgcca gucaaguaac aaccgcgaaa aaguugcgcg gaggaguugu guuuguggac 1560
gaaguaccga aaggucuuac cggaaaacuc gacgcaagaa aaaucagaga gauccucaua 1620
aaggccaaga agggcggaaa gaucgccgug uaa                              1653

<210> 17
<211> 22
<212> RNA
<213> Artificial Sequence

<220> 
<223> Anti-luciferase target sequence

<400> 17
cuuacgcuga guacuucgaa au                                          22

<210> 18
<211> 112
<212> RNA
<213> Artificial Sequence

<220> 
<223> Anti-luciferase asymmetric siRNA molecule

<400> 18
cuucgaaauu uucuauucga ccuucagaag agggucgaau agaaaauuuc gaaguacuca 60
gcguaaguug uagguggcau uucagaagag augccaccua caacuuacgc ug         112

<210> 19
<211> 99
<212> RNA
<213> Artificial Sequence

<220> 
<223> Anti-luciferase asymmetric shRNA molecule

<400> 19
cuucgaaauu uccaucuucc agcggaugga aauuucgaag uacucagcgu aaguuguagg 60
uggcauuuca gaagagaugc caccuacaac aacuccucu                        99

<210> 20
<211> 372
<212> DNA
<213> Staphylococcus aureus

<400> 20
atggataata aaacgtatga aatatcatct gcagaatggg aatttatgaa tatcatttgg 60
atgaaaaaat atgcaagtgc gaataatata atagaagaaa tacaaatgca aaaggactgg 120
agtccaaaaa ccattcgtac acttataacg agattgtata aaaagggatt tatagatcgt 180
aaaaaagaca ataaaatttt tcaatattac tctcttgtag aagaaagtga tataaaatat 240
aaaacatcta aaaactttat caataaagta tacaaaggcg gtttcaattc acttgtctta 300
aactttgtag aaaaagaaga tctatcacaa gatgaaatag aagaattgag aaatatattg 360
aataaaaaat aa                                                     372

<210> 21
<211> 22
<212> DNA
<213> Staphylococcus aureus

<220> 
<223> Asymmetric motif

<400> 21
tacaaaggcg gtttcaattc ac                                          22

<210> 22
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Asymmetric motif

<400> 22
gtgaattgaa accgcctttg ta                                          22

<210> 23
<211> 1758
<212> DNA
<213> Staphylococcus aureus

<400> 23
gtgttatcat cttttttaat gttaagtata atcagttcat tgctcacgat atgtgtaatt 60
tttttagtga gaatgctcta tataaaatat actcaaaata ttatgtcaca taagatttgg 120
ttattagtgc tcgtctccac gttaattcca ttaataccat tttacaaaat atcgaatttt 180
acattttcaa aagatatgat gaatcgaaat gtatctgaca cgacttcttc ggttagtcat 240
atgttagatg gtcaacaatc atctgttacg aaagacttag caattaatgt taatcagttt 300
gagacctcaa atataacgta tatgattctt ttgatatggg tatttggtag tttgttgtgc 360
ttattttata tgattaaggc attccgacaa attgatgtta ttaaaagttc gtcattggaa 420
tcgtcatatc ttaatgaacg acttaaagta tgtcaaagta agatgcagtt ctacaaaaag 480
catataacaa ttagttatag ttcaaacatt gataatccga tggtatttgg tttagtgaaa 540
tcccaaattg tactaccaac tgtcgtagtc gaaaccatga atgacaaaga aattgaatat 600
attattctac atgaactatc acatgtgaaa agtcatgact taatattcaa ccagctttat 660
gttgttttta aaatgatatt ctggtttaat cctgcactat atataagtaa aacaatgatg 720
gacaatgact gtgaaaaagt atgtgataga aacgttttaa aaattttgaa tcgccatgaa 780
catatacgtt atggtgaatc gatattaaaa tgctctattt taaaatctca gcacataaat 840
aatgtggcag cacaatattt actaggtttt aattcaaata ttaaagaacg tgttaagtat 900
attgcacttt atgattcaat gcctaaacct aatcgaaaca agcgtattgt tgcgtatatt 960
gtatgtagta tatcgctttt aatacaagca ccgttactat ctgcacatgt tcaacaagac 1020
aaatatgaaa caaatgtatc atataaaaaa ttaaatcaac tagctccgta tttcaaagga 1080
tttgatggaa gttttgtgct ttataatgaa cgggagcaag cttattctat ttataatgaa 1140
ccagaaagta aacaacgata ttcacctaat tctacttaca aaatttattt agcgttaatg 1200
gcattcgacc aaaatttact ctcattaaat catactgaac aacaatggga taaacatcaa 1260
tatccattta aagaatggaa ccaagatcaa aatttaaatt cttcaatgaa atattcagta 1320
aattggtatt acgaaaattt aaacaaacat ttaagacaag atgaggttaa atcttattta 1380
gatctaattg aatatggtaa tgaagaaata tcagggaatg aaaattattg gaatgaatct 1440
tcattaaaaa tttctgcaat agaacaggtt aatttgttga aaaatatgaa acaacataac 1500
atgcattttg ataataaggc tattgaaaaa gttgaaaata gtatgacttt gaaacaaaaa 1560
gatacttata aatatgtagg taaaactgga acaggaatcg tgaatcacaa agaagcaaat 1620
ggatggttcg taggttatgt tgaaacgaaa gataatacgt attattttgc tacacattta 1680
aaaggcgaag acaatgcgaa tggcgaaaaa gcacaacaaa tttctgagcg tattttaaaa 1740
gaaatggagt taatataa                                               1758

<210> 24
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> Asymmetric RNAi motif

<400> 24
uacggagcua guugauuua                                              19

<210> 25
<211> 705
<212> DNA
<213> Unknown

<220> 
<223> Unknown species for Toxic Shock Gene

<400> 25
atgaataaaa aattactaat gaattttttt atcgtaagcc ctttgttgct tgcgacaatc 60
gctacagatt ttacccctgt tcccttatca tctaatcaaa taatcaaaac tgcaaaagca 120
tctacaaacg ataatataaa ggatttgcta gactggtata gtagtgggtc tgacactttt 180
acaaatagtg aagttttaga taattcctta ggatctatgc gtataaaaaa cacagatggc 240
agcatcagcc ttataatttt tccgagtcct tattatagcc ctgcttttac aaaaggggaa 300
aaagttgact taaacacaaa aagaactaaa aaaagccaac atactagcga aggaacttat 360
atccatttcc aaataagtgg cgttacaaat actgaaaaat tacctactcc aatagaacta 420
cctttaaaag ttaaggttca tggtaaagat agccccttaa agtattggcc aaagttcgat 480
aaaaaacaat tagctatatc aactttagac tttgaaattc gtcatcagct aactcaaata 540
catggattat atcgttcaag cgataaaacg ggtggttatt ggaaaataac aatgaatgac 600
ggatccacat atcaaagtga tttatctaaa aagtttgaat acaatactga aaaaccacct 660
ataaatattg atgaaataaa aactatagaa gcagaaatta attaa                 705

<210> 26
<211> 22
<212> DNA
<213> Staphylococcus aureus

<400> 26
tacaaaggcg gtttcaattc ac                                          22

<210> 27
<211> 24
<212> DNA
<213> Unknown

<220> 
<223> Unknown species for Toxic Shock Gene target
      sequence

<400> 27
tcgtaagccc tttgttgctt gcga                                        24

<210> 28
<211> 24
<212> RNA
<213> Unknown

<220> 
<223> Unknown species for Toxic Shock Gene naturally
      occurring stem loop

<400> 28
agcauucggg aaacaacgaa cgcu                                        24

<210> 29
<211> 63
<212> DNA
<213> Unknown

<220> 
<223> Unknown species for Toxic Shock Gene

<400> 29
atgaataaaa aattactaat gaattttttt atcgtaagcc ctttgttgct tgcgacaatc 60
gct                                                               63

<210> 30
<211> 112
<212> RNA
<213> Artificial Sequence

<220> 
<223> Anit-MRSA/TST asymmetric siRNA molecule

<400> 30
ucaauucacu uucuauucga ccuucagaag agggucgaau agaaagugaa uugaaaccgc 60
cuuuguauug uagguggcau uucagaagag augccaccua caauacaaag gc         112

<210> 31
<211> 96
<212> RNA
<213> Artificial Sequence

<220> 
<223> Anit-MRSA/TST asymmetric shRNA molecule

<400> 31
ucaauucacg caagcaacaa agggcuugcg ugaauugaaa ccgccuuugu auuguaggug 60
gcauuucaga agagaugcca ccuacaauac aaaggc                           96

<210> 32
<211> 22
<212> RNA
<213> Human Immunodeficiency Virus

<400> 32
ugugccuggc uagaagcaca ag                                          22

<210> 33
<211> 112
<212> RNA
<213> Artificial Sequence

<220> 
<223> Anit-HIV nef asymmetric siRNA molecule

<400> 33
aagcacaagu uucuauucga ccuucagaag agggucgaau agaaacuugu gcuucuagcc 60
aggcacauug uagguggcau uucagaagag augccaccua caaugugccu gg         112

<210> 34
<211> 88
<212> RNA
<213> Artificial Sequence

<220> 
<223> Anit-HIV nef asymmetric shRNA molecule

<400> 34
aagcacaagu ugcgugguaa acuugugcuu cuagccaggc acauuguagg uggcauuuca 60
gaagagaugc caccuacaau gugccugg                                    88

<210> 35
<211> 2451
<212> RNA
<213> Homo sapiens

<400> 35
cgugcuuucc acgacgguga cacgcuuccc uggauuggcc agacugccuu ccgggucacu 60
gccauggagg agccgcaguc agauccuagc gucgagcccc cucugaguca ggaaacauuu 120
ucagaccuau ggaaacuacu uccugaaaac aacguucugu cccccuugcc gucccaagca 180
auggaugauu ugaugcuguc cccggacgau auugaacaau gguucacuga agacccaggu 240
ccagaugaag cucccagaau gccagaggcu gcuccccgcg uggccccugc accagcagcu 300
ccuacaccgg cggccccugc accagccccc uccuggcccc ugucaucuuc ugucccuucc 360
cagaaaaccu accagggcag cuacgguuuc cgucugggcu ucuugcauuc ugggacagcc 420
aagucuguga cuugcacgua cuccccugcc cucaacaaga uguuuugcca acuggccaag 480
accugcccug ugcagcugug gguugauucc acacccccgc ccggcacccg cguccgcgcc 540
auggccaucu acaagcaguc acagcacaug acggagguug ugaggcgcug cccccaccau 600
gagcgcugcu cagauagcga uggucuggcc ccuccucagc aucuuauccg aguggaagga 660
aauuugcgug uggaguauuu ggaugacaga aacacuuuuc gacauagugu gguggugccc 720
uaugagccgc cugagguugg cucugacugu accaccaucc acuacaacua cauguguaac 780
aguuccugca ugggcggcau gaaccggagg cccauccuca ccaucaucac acuggaagac 840
uccaguggua aucuacuggg acggaacagc uuugaggugc auguuugugc cuguccuggg 900
agagaccggc gcacagagga agagaaucuc cgcaagaaag gggagccuca ccacgagcug 960
cccccaggga gcacuaagcg agcacugucc aacaacacca gcuccucucc ccagccaaag 1020
aagaaaccac uggauggaga auauuucacc cuucagaucc gugggcguga gcgcuucgag 1080
auguuccgag agcugaauga ggccuuggaa cucaaggaug cccaggcugg gaaggagcca 1140
ggggggagca gggcucacuc cagccaccug aaguccaaaa agggucaguc uaccucccgc 1200
cauaaaaaac ucauguucaa gacagaaggg ccugacucag acugacauuc uccacuucuu 1260
guuccccacu gacagccucc cacccccauc ucucccuccc cugccauuuu ggguuuuggg 1320
ucuuugaacc cuugcuugca auaggugugc gucagaagca cccaggacuu ccauuugcuu 1380
ugucccgggg cuccacugaa caaguuggcc ugcacuggug uuuuguugug gggaggagga 1440
uggggaguag gacauaccag cuuagauuuu aagguuuuua cugugaggga uguuugggag 1500
auguaagaaa uguucuugca guuaaggguu aguuuacaau cagccacauu cuagguaggg 1560
gcccacuuca ccguacuaac cagggaagcu gucccucacu guugaauuuu cucuaacuuc 1620
aaggcccaua ucugugaaau gcuggcauuu gcaccuaccu cacagagugc auugugaggg 1680
uuaaugaaau aauguacauc uggccuugaa accaccuuuu auuacauggg gucuagaacu 1740
ugacccccuu gagggugcuu guucccucuc ccuguugguc gguggguugg uaguuucuac 1800
aguugggcag cugguuaggu agagggaguu gucaagucuc ugcuggccca gccaaacccu 1860
gucugacaac cucuugguga accuuaguac cuaaaaggaa aucucacccc aucccacacc 1920
cuggaggauu ucaucucuug uauaugauga ucuggaucca ccaagacuug uuuuaugcuc 1980
agggucaauu ucuuuuuucu uuuuuuuuuu uuuuuucuuu uucuuugaga cugggucucg 2040
cuuuguugcc caggcuggag uggaguggcg ugaucuuggc uuacugcagc cuuugccucc 2100
ccggcucgag caguccugcc ucagccuccg gaguagcugg gaccacaggu ucaugccacc 2160
auggccagcc aacuuuugca uguuuuguag agaugggguc ucacaguguu gcccaggcug 2220
gucucaaacu ccugggcuca ggcgauccac cugucucagc cucccagagu gcugggauua 2280
caauugugag ccaccacguc cagcuggaag ggucaacauc uuuuacauuc ugcaagcaca 2340
ucugcauuuu caccccaccc uuccccuccu ucucccuuuu uauaucccau uuuuauaucg 2400
aucucuuauu uuacaauaaa acuuugcugc caaaaaaaaa aaaaaaaaaa a          2451

<210> 36
<211> 22
<212> RNA
<213> Homo sapiens

<400> 36
cccugcccuc aacaagaugu uu                                          22

<210> 37
<211> 112
<212> RNA
<213> Artificial Sequence

<220> 
<223> Anit-p53 asymmetric siRNA molecule

<400> 37
aagauguuuu uucuauucga ccuucagaag agggucgaau agaaaaaaca ucuuguugag 60
ggcaggguug uagguggcau uucagaagag augccaccua caacccugcc cu         112

<210> 38
<211> 92
<212> RNA
<213> Artificial Sequence

<220> 
<223> Anit-p53 asymmetric shRNA molecule

<400> 38
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uucagaagag augccaccua caacccugcc cu                               92
