                         SEQUENCE LISTING

<110>  NoNO, Inc.
       Arbor Vita Corporation
       Tymianski, Michael
       Garman, Jonathan  D
 
<120>  CO-ADMINISTRATION OF AN AGENT LINKED TO AN INTERNALIZATION 
       PEPTIDE WITH AN ANTI-INFLAMMATORY

<130>  026373-000910US

<150>  US 60/992,678
<151>  2007-12-05

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  1

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10  


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  2

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  3

Phe Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  4

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
1               5                   10          


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pharmacologic agent

<400>  5

Lys Leu Ser Ser Ile Glu Ser Asp Val 
1               5                   


<210>  6
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Tat-NR2B9c peptide

<400>  6

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Leu Ser Ser Ile 
1               5                   10                  15      


Glu Ser Asp Val 
            20  


<210>  7
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Tat-NR2B9c peptide with 2 point mutations in the PSD-95
       binding domain

<400>  7

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Leu Ser Ser Ile 
1               5                   10                  15      


Glu Ala Asp Ala 
            20  


<210>  8
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic F-Tat-NR2B9c peptide

<400>  8

Phe Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Lys Leu Ser Ser Ile 
1               5                   10                  15      


Glu Ser Asp Val 
            20  


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Tat-NR2B9c K>A peptide

<400>  9

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Ala Leu Ser Ser Ile 
1               5                   10                  15      


Glu Ser Asp Val 
            20  


<210>  10
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic F-Tat-NR2B9c K>A peptide

<400>  10

Phe Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Ala Leu Ser Ser Ile 
1               5                   10                  15      


Glu Ser Asp Val 
            20  


<210>  11
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 20-mer sequence of NMDAR2B

<400>  11

Phe Asn Gly Ser Ser Asn Gly His Val Tyr Glu Lys Leu Ser Ser Ile 
1               5                   10                  15      


Glu Ser Asp Val 
            20  


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  PL motif of NMDAR2B

<400>  12

Glu Ser Asp Val 
1               


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 20-mer sequence of NMDAR1, NMDAR1-1, 
       NMDAR1-4, NMDAR1-3b, NMDAR1-4b

<400>  13

His Pro Thr Asp Ile Thr Gly Pro Leu Asn Leu Ser Asp Pro Ser Val 
1               5                   10                  15      


Ser Thr Val Val 
            20  


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 20-mer sequence of NMDAR1-2, NMDAR1-3

<400>  14

Arg Arg Ala Ile Glu Arg Glu Glu Gly Gln Leu Gln Leu Cys Ser Arg 
1               5                   10                  15      


His Arg Glu Ser 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 20-mer sequence of NMDAR2C

<400>  15

Thr Gln Gly Phe Pro Gly Pro Cys Thr Trp Arg Arg Ile Ser Ser Leu 
1               5                   10                  15      


Glu Ser Glu Val 
            20  


<210>  16
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 20-mer sequence of NMDAR3A

<400>  16

Ala Val Ser Arg Lys Thr Glu Leu Glu Glu Tyr Gln Arg Thr Ser Arg 
1               5                   10                  15      


Thr Cys Glu Ser 
            20  


<210>  17
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 20-mer sequence of NMDAR2A

<400>  17

Leu Asn Ser Cys Ser Asn Arg Arg Val Tyr Lys Lys Met Pro Ser Ile 
1               5                   10                  15      


Glu Ser Asp Val 
            20  


<210>  18
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 20-mer sequence of NMDAR2D

<400>  18

Gly Gly Asp Leu Gly Thr Arg Arg Gly Ser Ala His Phe Ser Ser Leu 
1               5                   10                  15      


Glu Ser Glu Val 
            20  


<210>  19
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 20-mer sequence of glutamate receptor delta
       2

<400>  19

Gln Pro Thr Pro Thr Leu Gly Leu Asn Leu Gly Asn Asp Pro Asp Arg 
1               5                   10                  15      


Gly Thr Ser Ile 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 20-mer sequence of glutamate receptor 1

<400>  20

Met Gln Ser Ile Pro Cys Met Ser His Ser Ser Gly Met Pro Leu Gly 
1               5                   10                  15      


Ala Thr Gly Leu 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 20-mer sequence of glutamate receptor 2

<400>  21

Gln Asn Phe Ala Thr Tyr Lys Glu Gly Tyr Asn Val Tyr Gly Ile Glu 
1               5                   10                  15      


Ser Val Lys Ile 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 20-mer sequence of glutamate receptor 3

<400>  22

Gln Asn Tyr Ala Thr Tyr Arg Glu Gly Tyr Asn Val Tyr Gly Thr Glu 
1               5                   10                  15      


Ser Val Lys Ile 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 20-mer sequence of glutamate receptor 4

<400>  23

His Thr Gly Thr Ala Ile Arg Gln Ser Ser Gly Leu Ala Val Ile Ala 
1               5                   10                  15      


Ser Asp Leu Pro 
            20  


<210>  24
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 20-mer sequence of glutamate receptor 5

<400>  24

Ser Phe Thr Ser Ile Leu Thr Cys His Gln Arg Arg Thr Gln Arg Lys 
1               5                   10                  15      


Glu Thr Val Ala 
            20  


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 20-mer sequence of glutamate receptor 6

<400>  25

Glu Val Ile Asn Met His Thr Phe Asn Asp Arg Arg Leu Pro Gly Lys 
1               5                   10                  15      


Glu Thr Met Ala 
            20  


<210>  26
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 20-mer sequence of glutamate receptor 7

<400>  26

Arg Arg Leu Pro Gly Lys Asp Ser Met Ala Cys Ser Thr Ser Leu Ala 
1               5                   10                  15      


Pro Val Phe Pro 
            20  


<210>  27
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 4-mer sequence of NMDAR1, NMDAR1-1, 
       NMDAR1-4, NMDAR1-3b, NMDAR1-4b

<400>  27

Ser Thr Val Val 
1               


<210>  28
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 4-mer sequence of NMDAR1-2, NMDAR1-3

<400>  28

His Arg Glu Ser 
1               


<210>  29
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 4-mer sequence of NMDAR2C, NMDAR2D

<400>  29

Glu Ser Glu Val 
1               


<210>  30
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 4-mer sequence of NMDAR3A

<400>  30

Thr Cys Glu Ser 
1               


<210>  31
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 4-mer sequence of glutamate receptor delta 
       2

<400>  31

Gly Thr Ser Ile 
1               


<210>  32
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 4-mer sequence of glutamate receptor 1

<400>  32

Ala Thr Gly Leu 
1               


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 4-mer sequence of glutamate receptor 2 and 
       glutamate receptor 3

<400>  33

Ser Val Lys Ile 
1               


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 4-mer sequence of glutamate receptor 4

<400>  34

Ser Asp Leu Pro 
1               


<210>  35
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 4-mer sequence of glutamate receptor 5

<400>  35

Glu Thr Val Ala 
1               


<210>  36
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 4-mer sequence of glutamate receptor 6

<400>  36

Glu Thr Met Ala 
1               


<210>  37
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  C-terminal 4-mer sequence of glutamate receptor 7

<400>  37

Pro Val Phe Pro 
1               


<210>  38
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa = Glu, Asp, Asn or Gln

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa = Ser or Thr

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa = Asp, Glu, Gln or Asn

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa = Val or Leu

<400>  38

Xaa Xaa Xaa Xaa 
1               


<210>  39
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  39

Glu Thr Asp Val 
1               


<210>  40
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  40

Glu Thr Glu Val 
1               


<210>  41
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  41

Asp Thr Asp Val 
1               


<210>  42
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  42

Asp Thr Glu Val 
1               


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  43

Lys Leu Ser Ser Ile Glu Thr Asp Val 
1               5                   


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  44

Gly Ser Ser Ser Ser 
1               5   


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  45

Thr Gly Glu Lys Pro 
1               5   


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  46

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  47

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  48
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  48

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
1               5                   10              


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variant of tat peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is any amino acid other than Tyr or absent

<400>  49

Xaa Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  50

Gly Lys Lys Lys Lys Lys Gln Lys Lys Lys 
1               5                   10  


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  51

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  52

Gly Ala Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10  


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  53

Ala Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  54

Gly Arg Lys Ala Arg Arg Gln Arg Arg Arg 
1               5                   10  


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  55

Arg Lys Ala Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  56

Gly Arg Lys Lys Ala Arg Gln Arg Arg Arg 
1               5                   10  


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  57

Arg Lys Lys Ala Arg Gln Arg Arg Arg 
1               5                   


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  58

Gly Arg Lys Lys Arg Arg Gln Ala Arg Arg 
1               5                   10  


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  59

Arg Lys Lys Arg Arg Gln Ala Arg Arg 
1               5                   


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  60

Gly Arg Lys Lys Arg Arg Gln Arg Ala Arg 
1               5                   10  


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  61

Arg Lys Lys Arg Arg Gln Arg Ala Arg 
1               5                   


<210>  62
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  62

Arg Arg Pro Arg Arg Pro Arg Arg Pro Arg Arg 
1               5                   10      


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  63

Arg Arg Ala Arg Arg Ala Arg Arg Ala Arg Arg 
1               5                   10      


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  64

Arg Arg Arg Ala Arg Arg Arg Ala Arg Arg 
1               5                   10  


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  65

Arg Arg Arg Pro Arg Arg Arg Pro Arg Arg 
1               5                   10  


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  66

Arg Arg Pro Arg Arg Pro Arg Arg 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tat peptide

<400>  67

Arg Arg Ala Arg Arg Ala Arg Arg 
1               5               


