                               SEQUENCE LISTING

<110> UNIVERSITY OF KANSAS
 
<120> METHODS FOR TREATING A DISORDER BY REGULATING GPRC6A

<130> 16994.25.1a

<140>
<141>

<150> 60/991,188
<151> 2007-11-29

<160> 36    

<170> PatentIn version 3.5

<210> 1
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 1
ctagataccg ttcgtatagc atacattata cgaagttatg                           40


<210> 2
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 2
agcttataac ttcgtatagc atacattata cgaacggtag                           40


<210> 3
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 3
aaacctaggg ccattcatga aaaaatgttg tcctcagatg accatcc                   47


<210> 4
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 4
aaacctaggc tcactcaacc cccatgtcct tccaactcta gctg                      44


<210> 5
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 5
aaagtcgacc tacattggtc catcgattac attagttctt gg                        42


<210> 6
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 6
aaagtcgacg aggccttgag gtcaaactcc agaaccccag ag                        42


<210> 7
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 7
ccagaaagat ggccctattg a                                               21


<210> 8
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 8
ctccttactg gggcccagtg gg                                              22


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 9
caacttgcat gtggatgacc                                                 20


<210> 10
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 10
cttgagcagg atgtgggatt c                                               21


<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 11
agcactggtc ctatgggttg                                                 20


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 12
gggccagtgc atctacatct                                                 20


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 13
ccacctatgc catctccagt                                                 20


<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 14
accatgctga caatgatgga                                                 20


<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 15
aacccagaca caagcattcc                                                 20


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 16
ctgggcctgg tagttgttgt                                                 20


<210> 17
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 17
gaccccttca ttgacctcaa ctaca                                           25


<210> 18
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 18
ggtcttactc cttggaggcc atgt                                            24


<210> 19
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 19
tgagaacggc atcatattta acaac                                           25


<210> 20
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 20
gcccgtcaga gctttcataa ag                                              22


<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 21
tggaggccac tatccgagaa                                                 20


<210> 22
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 22
tgttagcctt gtgtgggatg ag                                              22


<210> 23
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 23
tcatgcgaaa gggaattata gga                                             23


<210> 24
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 24
tgcttgtagt gctcatcaaa tctct                                           25


<210> 25
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 25
cgggatccag acgaccacaa atccag                                          26


<210> 26
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 26
ccaagcttga ttcataactc acctgtggc                                       29


<210> 27
<211> 21
<212> PRT
<213> Mus sp.

<400> 27
Ala Ile His Glu Lys Met Leu Ser Ser Asp Asp His Pro Arg Arg Pro 
1               5                   10                  15      


Gln Ile Gln Lys Cys 
            20      


<210> 28
<211> 2860
<212> DNA
<213> Homo sapiens

<400> 28
actgagcaaa tgagatagaa acatggcatt cttaattata ctaattacct gctttgtgat     60

tattcttgct acttcacagc cttgccagac ccctgatgac tttgtggctg ccacttctcc    120

gggacatatc ataattggag gtttgtttgc tattcatgaa aaaatgttgt cctcagaaga    180

ctctcccaga cgaccacaaa tccaggagtg tgttggcttt gaaatatcag tttttcttca    240

aactcttgcc atgatacaca gcattgagat gatcaacaat tcaacactct tacctggagt    300

caaactgggg tatgaaatct atgacacttg tacagaagtc acagtggcaa tggcagccac    360

tctgaggttt ctttctaaat tcaactgctc cagagaaact gtggagttta agtgtgacta    420

ttccagctac atgccaagag ttaaggctgt cataggttct gggtactcag aaataactat    480

ggctgtctcc aggatgttga atttacagct catgccacag gtgggttatg aatcaactgc    540

agaaatcctg agtgacaaaa ttcgctttcc ttcattttta cggactgtgc ccagtgactt    600

ccatcaaatt aaagcaatgg ctcacctgat tcagaaatct ggttggaact ggattggcat    660

cataaccaca gatgatgact atggacgatt ggctcttaac acttttataa ttcaggctga    720

agcaaataac gtgtgcatag ccttcaaaga ggttcttcca gcctttcttt cagataatac    780

cattgaagtc agaatcaatc ggacactgaa gaaaatcatt ttagaagccc aggttaatgt    840

cattgtggta tttctgaggc aattccatgt ttttgatctc ttcaataaag ccattgaaat    900

gaatataaat aagatgtgga ttgctagtga taattggtca actgccacca agattaccac    960

cattcctaat gttaaaaaga ttggcaaagt tgtagggttt gcctttagaa gagggaatat   1020

atcctctttc cattcctttc ttcaaaatct gcacttgctt cccagtgaca gtcacaaact   1080

cttacatgaa tatgccatgc atttatctgc ctgcgcatat gtcaaggaca ctgatttgag   1140

tcaatgcata ttcaatcatt ctcaaaggac tttggcctac aaggctaaca aggctataga   1200

aaggaacttc gtcatgagaa atgacttcct ctgggactat gctgagccag gactcattca   1260

tagtattcag cttgcagtgt ttgcccttgg ttatgccatt cgggatctgt gtcaagctcg   1320

tgactgtcag aaccccaacg cctttcaacc atgggagtta cttggtgtgc taaaaaatgt   1380

gacattcact gatggatgga attcatttca ttttgatgct cacggggatt taaatactgg   1440

atatgatgtt gtgctctgga aggagatcaa tggacacatg actgtcacta agatggcaga   1500

atatgaccta cagaatgatg tcttcatcat cccagatcag gaaacaaaaa atgagttcag   1560

gaatcttaag caaattcaat ctaaatgctc caaggaatgc agtcctgggc aaatgaagaa   1620

aactacaaga agtcaacaca tctgttgcta tgaatgtcag aactgtcctg aaaatcatta   1680

cactaatcag acagatatgc ctcactgcct tttatgcaac aacaaaactc actgggcccc   1740

tgttaggagc actatgtgct ttgaaaagga agtggaatat ctcaactgga atgactcctt   1800

ggccatccta ctcctgattc tctccctact gggaatcata tttgttctgg ttgttggcat   1860

aatatttaca agaaacctga acacacctgt tgtgaaatca tccgggggat taagagtctg   1920

ctatgtgatc cttctctgtc atttcctcaa ttttgccagc acgagctttt tcattggaga   1980

accacaagac ttcacatgta aaaccaggca gacaatgttt ggagtgagct ttactctttg   2040

catctcctgc attttgacga agtctctgaa aattttgcta gccttcagct ttgatcccaa   2100

attacagaaa tttctgaagt gcctctatag accgatcctt attatcttca cttgcacggg   2160

catccaggtt gtcatttgca cactctggct aatctttgca gcacctactg tagaggtgaa   2220

tgtctccttg cccagagtca tcatcctgga gtgtgaggag ggatccatac ttgcatttgg   2280

caccatgctg ggctacattg ccatcctggc cttcatttgc ttcatatttg ctttcaaagg   2340

caaatatgag aattacaatg aagccaaatt cattacattt ggcatgctca tttacttcat   2400

agcttggatc acattcatcc ctatctatgc taccacattt ggcaaatatg taccagctgt   2460

ggagattatt gtcatattaa tatctaacta tggaatcctg tattgcacat tcatccccaa   2520

atgctatgtt attatttgta agcaagagat taacacaaag tctgcctttc tcaagatgat   2580

ctacagttat tcttcccata gtgtgagcag cattgccctg agtcctgctt cactggactc   2640

catgagcggc aatgtcacaa tgaccaatcc cagctctagt ggcaagtctg caacctggca   2700

gaaaagcaaa gatcttcagg cacaagcatt tgcacacata tgcagggaaa atgccacaag   2760

tgtatctaaa actttgcctc gaaaaagaat gtcaagtata tgaataagcc ttaggagatg   2820

ccacattcca gaataaaatg tttccagggt ctttgcatct                         2860


<210> 29
<211> 926
<212> PRT
<213> Homo sapiens

<400> 29
Met Ala Phe Leu Ile Ile Leu Ile Thr Cys Phe Val Ile Ile Leu Ala 
1               5                   10                  15      


Thr Ser Gln Pro Cys Gln Thr Pro Asp Asp Phe Val Ala Ala Thr Ser 
            20                  25                  30          


Pro Gly His Ile Ile Ile Gly Gly Leu Phe Ala Ile His Glu Lys Met 
        35                  40                  45              


Leu Ser Ser Glu Asp Ser Pro Arg Arg Pro Gln Ile Gln Glu Cys Val 
    50                  55                  60                  


Gly Phe Glu Ile Ser Val Phe Leu Gln Thr Leu Ala Met Ile His Ser 
65                  70                  75                  80  


Ile Glu Met Ile Asn Asn Ser Thr Leu Leu Pro Gly Val Lys Leu Gly 
                85                  90                  95      


Tyr Glu Ile Tyr Asp Thr Cys Thr Glu Val Thr Val Ala Met Ala Ala 
            100                 105                 110         


Thr Leu Arg Phe Leu Ser Lys Phe Asn Cys Ser Arg Glu Thr Val Glu 
        115                 120                 125             


Phe Lys Cys Asp Tyr Ser Ser Tyr Met Pro Arg Val Lys Ala Val Ile 
    130                 135                 140                 


Gly Ser Gly Tyr Ser Glu Ile Thr Met Ala Val Ser Arg Met Leu Asn 
145                 150                 155                 160 


Leu Gln Leu Met Pro Gln Val Gly Tyr Glu Ser Thr Ala Glu Ile Leu 
                165                 170                 175     


Ser Asp Lys Ile Arg Phe Pro Ser Phe Leu Arg Thr Val Pro Ser Asp 
            180                 185                 190         


Phe His Gln Ile Lys Ala Met Ala His Leu Ile Gln Lys Ser Gly Trp 
        195                 200                 205             


Asn Trp Ile Gly Ile Ile Thr Thr Asp Asp Asp Tyr Gly Arg Leu Ala 
    210                 215                 220                 


Leu Asn Thr Phe Ile Ile Gln Ala Glu Ala Asn Asn Val Cys Ile Ala 
225                 230                 235                 240 


Phe Lys Glu Val Leu Pro Ala Phe Leu Ser Asp Asn Thr Ile Glu Val 
                245                 250                 255     


Arg Ile Asn Arg Thr Leu Lys Lys Ile Ile Leu Glu Ala Gln Val Asn 
            260                 265                 270         


Val Ile Val Val Phe Leu Arg Gln Phe His Val Phe Asp Leu Phe Asn 
        275                 280                 285             


Lys Ala Ile Glu Met Asn Ile Asn Lys Met Trp Ile Ala Ser Asp Asn 
    290                 295                 300                 


Trp Ser Thr Ala Thr Lys Ile Thr Thr Ile Pro Asn Val Lys Lys Ile 
305                 310                 315                 320 


Gly Lys Val Val Gly Phe Ala Phe Arg Arg Gly Asn Ile Ser Ser Phe 
                325                 330                 335     


His Ser Phe Leu Gln Asn Leu His Leu Leu Pro Ser Asp Ser His Lys 
            340                 345                 350         


Leu Leu His Glu Tyr Ala Met His Leu Ser Ala Cys Ala Tyr Val Lys 
        355                 360                 365             


Asp Thr Asp Leu Ser Gln Cys Ile Phe Asn His Ser Gln Arg Thr Leu 
    370                 375                 380                 


Ala Tyr Lys Ala Asn Lys Ala Ile Glu Arg Asn Phe Val Met Arg Asn 
385                 390                 395                 400 


Asp Phe Leu Trp Asp Tyr Ala Glu Pro Gly Leu Ile His Ser Ile Gln 
                405                 410                 415     


Leu Ala Val Phe Ala Leu Gly Tyr Ala Ile Arg Asp Leu Cys Gln Ala 
            420                 425                 430         


Arg Asp Cys Gln Asn Pro Asn Ala Phe Gln Pro Trp Glu Leu Leu Gly 
        435                 440                 445             


Val Leu Lys Asn Val Thr Phe Thr Asp Gly Trp Asn Ser Phe His Phe 
    450                 455                 460                 


Asp Ala His Gly Asp Leu Asn Thr Gly Tyr Asp Val Val Leu Trp Lys 
465                 470                 475                 480 


Glu Ile Asn Gly His Met Thr Val Thr Lys Met Ala Glu Tyr Asp Leu 
                485                 490                 495     


Gln Asn Asp Val Phe Ile Ile Pro Asp Gln Glu Thr Lys Asn Glu Phe 
            500                 505                 510         


Arg Asn Leu Lys Gln Ile Gln Ser Lys Cys Ser Lys Glu Cys Ser Pro 
        515                 520                 525             


Gly Gln Met Lys Lys Thr Thr Arg Ser Gln His Ile Cys Cys Tyr Glu 
    530                 535                 540                 


Cys Gln Asn Cys Pro Glu Asn His Tyr Thr Asn Gln Thr Asp Met Pro 
545                 550                 555                 560 


His Cys Leu Leu Cys Asn Asn Lys Thr His Trp Ala Pro Val Arg Ser 
                565                 570                 575     


Thr Met Cys Phe Glu Lys Glu Val Glu Tyr Leu Asn Trp Asn Asp Ser 
            580                 585                 590         


Leu Ala Ile Leu Leu Leu Ile Leu Ser Leu Leu Gly Ile Ile Phe Val 
        595                 600                 605             


Leu Val Val Gly Ile Ile Phe Thr Arg Asn Leu Asn Thr Pro Val Val 
    610                 615                 620                 


Lys Ser Ser Gly Gly Leu Arg Val Cys Tyr Val Ile Leu Leu Cys His 
625                 630                 635                 640 


Phe Leu Asn Phe Ala Ser Thr Ser Phe Phe Ile Gly Glu Pro Gln Asp 
                645                 650                 655     


Phe Thr Cys Lys Thr Arg Gln Thr Met Phe Gly Val Ser Phe Thr Leu 
            660                 665                 670         


Cys Ile Ser Cys Ile Leu Thr Lys Ser Leu Lys Ile Leu Leu Ala Phe 
        675                 680                 685             


Ser Phe Asp Pro Lys Leu Gln Lys Phe Leu Lys Cys Leu Tyr Arg Pro 
    690                 695                 700                 


Ile Leu Ile Ile Phe Thr Cys Thr Gly Ile Gln Val Val Ile Cys Thr 
705                 710                 715                 720 


Leu Trp Leu Ile Phe Ala Ala Pro Thr Val Glu Val Asn Val Ser Leu 
                725                 730                 735     


Pro Arg Val Ile Ile Leu Glu Cys Glu Glu Gly Ser Ile Leu Ala Phe 
            740                 745                 750         


Gly Thr Met Leu Gly Tyr Ile Ala Ile Leu Ala Phe Ile Cys Phe Ile 
        755                 760                 765             


Phe Ala Phe Lys Gly Lys Tyr Glu Asn Tyr Asn Glu Ala Lys Phe Ile 
    770                 775                 780                 


Thr Phe Gly Met Leu Ile Tyr Phe Ile Ala Trp Ile Thr Phe Ile Pro 
785                 790                 795                 800 


Ile Tyr Ala Thr Thr Phe Gly Lys Tyr Val Pro Ala Val Glu Ile Ile 
                805                 810                 815     


Val Ile Leu Ile Ser Asn Tyr Gly Ile Leu Tyr Cys Thr Phe Ile Pro 
            820                 825                 830         


Lys Cys Tyr Val Ile Ile Cys Lys Gln Glu Ile Asn Thr Lys Ser Ala 
        835                 840                 845             


Phe Leu Lys Met Ile Tyr Ser Tyr Ser Ser His Ser Val Ser Ser Ile 
    850                 855                 860                 


Ala Leu Ser Pro Ala Ser Leu Asp Ser Met Ser Gly Asn Val Thr Met 
865                 870                 875                 880 


Thr Asn Pro Ser Ser Ser Gly Lys Ser Ala Thr Trp Gln Lys Ser Lys 
                885                 890                 895     


Asp Leu Gln Ala Gln Ala Phe Ala His Ile Cys Arg Glu Asn Ala Thr 
            900                 905                 910         


Ser Val Ser Lys Thr Leu Pro Arg Lys Arg Met Ser Ser Ile 
        915                 920                 925     


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 30
caggagtgtg ttggctttga                                                 20


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 31
atcaggtgag ccattgcttt                                                 20


<210> 32
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 32
cgggatccag acgaccacaa atccag                                          26


<210> 33
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 33
ccaagcttga ttcataactc acctgt                                          26


<210> 34
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 34
cctggcttcc gcaacttaca c                                               21


<210> 35
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 35
gaccccttca ttgacctcaa ctaca                                           25


<210> 36
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic 
      primer

<400> 36
ggtcttactc cttggaggcc atgt                                            24
