                         SEQUENCE LISTING

<110>  Yale University
       Chupp, Geoffrey L
       Elias, Jack A
 
<120>  Variation in the CHI3L1 Gene Influences Serum YKL-40 Levels, 
       Asthma Risk, and Lung Function

<130>  047162-5041-00-WO (431488)

<150>  US 61/004548
<151>  2007-11-28

<160>  12    

<170>  PatentIn version 3.4

<210>  1
<211>  52
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = C or G

<400>  1
ctgcccttag tccctggcag actcctntga gctctttagt ttatccttct aa             52


<210>  2
<211>  52
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = A or T

<400>  2
ttgaaagaaa gtgccagctc ctcaatnaaa acatgctcga ggcagaccta cc             52


<210>  3
<211>  52
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = A or G

<400>  3
tttctcacat ggtcatcaga gtcacancgt atcctcagac ttcagcagag ca             52


<210>  4
<211>  52
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = G or T

<400>  4
gctagcgaaa ccagagccac atgatantga tgctttacag tgagcttctg tc             52


<210>  5
<211>  52
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = A or G

<400>  5
aaagtggctt gtccagaatc acgctcngtg aatactaaag aggcatcact tt             52


<210>  6
<211>  52
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = A or G

<400>  6
gattaccaga ggagggttga gaaaccncag agttttgaaa actttgggtc ag             52


<210>  7
<211>  52
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = C or G

<400>  7
tatatacctg tcccactcca ctccccnacg cggcaaacca gcccttttat gg             52


<210>  8
<211>  51
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = A or G

<400>  8
tgcagagcct gaaggagaag tctgggntgg ggcccgggcc aggattcggc a              51


<210>  9
<211>  52
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = C or T

<400>  9
tagggtggta aaatgctgtt tgtctcnccg tccagggtag agccaggcaa gg             52


<210>  10
<211>  52
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = A or G

<400>  10
ttccttatct gtggaatggg cctcatnacc cccctcttgc aggactgtac tg             52


<210>  11
<211>  1867
<212>  DNA
<213>  Homo sapiens

<400>  11
cacatagctc agttcccata aaagggctgg tttgccgcgt cggggagtgg agtgggacag     60

gtatataaag gaagtacagg gcctggggaa gaggccctgt ctaggtagct ggcaccagga    120

gccgtgggca agggaagagg ccacaccctg ccctgctctg ctgcagccag aatgggtgtg    180

aaggcgtctc aaacaggctt tgtggtcctg gtgctgctcc agtgctgctc tgcatacaaa    240

ctggtctgct actacaccag ctggtcccag taccgggaag gcgatgggag ctgcttccca    300

gatgcccttg accgcttcct ctgtacccac atcatctaca gctttgccaa tataagcaac    360

gatcacatcg acacctggga gtggaatgat gtgacgctct acggcatgct caacacactc    420

aagaacagga accccaacct gaagactctc ttgtctgtcg gaggatggaa ctttgggtct    480

caaagatttt ccaagatagc ctccaacacc cagagtcgcc ggactttcat caagtcagta    540

ccgccatttc tgcgcaccca tggctttgat gggctggacc ttgcctggct ctaccctgga    600

cggagagaca aacagcattt taccacccta atcaaggaaa tgaaggccga atttataaag    660

gaagcccagc cagggaaaaa gcagctcctg ctcagcgcag cactgtctgc ggggaaggtc    720

accattgaca gcagctatga cattgccaag atatcccaac acctggattt cattagcatc    780

atgacctacg attttcatgg agcctggcgt gggaccacag gccatcacag tcccctgttc    840

cgaggtcagg aggatgcaag tcctgacaga ttcagcaaca ctgactatgc tgtggggtac    900

atgttgaggc tgggggctcc tgccagtaag ctggtgatgg gcatccccac cttcgggagg    960

agcttcactc tggcttcttc tgagactggt gttggagccc caatctcagg accgggaatt   1020

ccaggccggt tcaccaagga ggcagggacc cttgcctact atgagatctg tgacttcctc   1080

cgcggagcca cagtccatag aatcctcggc cagcaggtcc cctatgccac caagggcaac   1140

cagtgggtag gatacgacga ccaggaaagc gtcaaaagca aggtgcagta cctgaaggac   1200

aggcagctgg cgggcgccat ggtatgggcc ctggacctgg atgacttcca gggctccttc   1260

tgcggccagg atctgcgctt ccctctcacc aatgccatca aggatgcact cgctgcaacg   1320

tagccctctg ttctgcacac agcacggggg ccaaggatgc cccgtccccc tctggctcca   1380

gctggccggg agcctgatca cctgccctgc tgagtcccag gctgagcctc agtctccctc   1440

ccttggggcc tatgcagagg tccacaacac acagatttga gctcagccct ggtgggcaga   1500

gaggtaggga tggggctgtg gggatagtga ggcatcgcaa tgtaagactc gggattagta   1560

cacacttgtt gattaatgga aatgtttaca gatccccaag cctggcaagg gaatttcttc   1620

aactccctgc cccccagccc tccttatcaa aggacaccat tttggcaagc tctatcacca   1680

aggagccaaa catcctacaa gacacagtga ccatactaat tataccccct gcaaagccca   1740

gcttgaaacc ttcacttagg aacgtaatcg tgtcccctat cctacttccc cttcctaatt   1800

ccacagctgc tcaataaagt acaagagctt aacagtgaaa aaaaaaaaaa aaaaaaaaaa   1860

aaaaaaa                                                             1867


<210>  12
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Val Lys Ala Ser Gln Thr Gly Phe Val Val Leu Val Leu Leu 
1               5                   10                  15      


Gln Cys Cys Ser Ala Tyr Lys Leu Val Cys Tyr Tyr Thr Ser Trp Ser 
            20                  25                  30          


Gln Tyr Arg Glu Gly Asp Gly Ser Cys Phe Pro Asp Ala Leu Asp Arg 
        35                  40                  45              


Phe Leu Cys Thr His Ile Ile Tyr Ser Phe Ala Asn Ile Ser Asn Asp 
    50                  55                  60                  


His Ile Asp Thr Trp Glu Trp Asn Asp Val Thr Leu Tyr Gly Met Leu 
65                  70                  75                  80  


Asn Thr Leu Lys Asn Arg Asn Pro Asn Leu Lys Thr Leu Leu Ser Val 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn 
            100                 105                 110         


Thr Gln Ser Arg Arg Thr Phe Ile Lys Ser Val Pro Pro Phe Leu Arg 
        115                 120                 125             


Thr His Gly Phe Asp Gly Leu Asp Leu Ala Trp Leu Tyr Pro Gly Arg 
    130                 135                 140                 


Arg Asp Lys Gln His Phe Thr Thr Leu Ile Lys Glu Met Lys Ala Glu 
145                 150                 155                 160 


Phe Ile Lys Glu Ala Gln Pro Gly Lys Lys Gln Leu Leu Leu Ser Ala 
                165                 170                 175     


Ala Leu Ser Ala Gly Lys Val Thr Ile Asp Ser Ser Tyr Asp Ile Ala 
            180                 185                 190         


Lys Ile Ser Gln His Leu Asp Phe Ile Ser Ile Met Thr Tyr Asp Phe 
        195                 200                 205             


His Gly Ala Trp Arg Gly Thr Thr Gly His His Ser Pro Leu Phe Arg 
    210                 215                 220                 


Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe Ser Asn Thr Asp Tyr Ala 
225                 230                 235                 240 


Val Gly Tyr Met Leu Arg Leu Gly Ala Pro Ala Ser Lys Leu Val Met 
                245                 250                 255     


Gly Ile Pro Thr Phe Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu Thr 
            260                 265                 270         


Gly Val Gly Ala Pro Ile Ser Gly Pro Gly Ile Pro Gly Arg Phe Thr 
        275                 280                 285             


Lys Glu Ala Gly Thr Leu Ala Tyr Tyr Glu Ile Cys Asp Phe Leu Arg 
    290                 295                 300                 


Gly Ala Thr Val His Arg Ile Leu Gly Gln Gln Val Pro Tyr Ala Thr 
305                 310                 315                 320 


Lys Gly Asn Gln Trp Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser 
                325                 330                 335     


Lys Val Gln Tyr Leu Lys Asp Arg Gln Leu Ala Gly Ala Met Val Trp 
            340                 345                 350         


Ala Leu Asp Leu Asp Asp Phe Gln Gly Ser Phe Cys Gly Gln Asp Leu 
        355                 360                 365             


Arg Phe Pro Leu Thr Asn Ala Ile Lys Asp Ala Leu Ala Ala Thr 
    370                 375                 380             


