                         SEQUENCE LISTING

<110>  Pincus, Matthew  R.
       Michl, Josef
       Adler, Victor
 
<120>  SMALL MOLECULE CANCER TREATMENTS THAT CAUSE NECROSIS IN CANCER 
       CELLS BUT DO NOT AFFECT NORMAL CELLS

<130>  178-365 PCT

<150>  60/990,276
<151>  2007-11-26

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide; amino acid residues 12-26 of human p53 protein

<400>  1

Pro Pro Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu 
1               5                   10                  15  


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide; amino acid residues 17-26 of human p53 protein

<400>  2

Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu 
1               5                   10  


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  membrane resident peptide (MRP), Antennapedia

<400>  3

Lys Lys Trp Lys Met Arg Arg Asn Gln Phe Trp Val Lys Val Gln Arg 
1               5                   10                  15      


Gly 
    


<210>  4
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence from cytochrom P450, used as a control

<400>  4

Met Pro Phe Ser Thr Gly Lys Arg Ile Met Leu Gly Glu 
1               5                   10              


<210>  5
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PNC-27

<400>  5

Pro Pro Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Lys 
1               5                   10                  15      


Lys Trp Lys Met Arg Arg Asn Gln Phe Trp Val Lys Val Gln Arg Gly 
            20                  25                  30          


<210>  6
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PNC-28

<400>  6

Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Lys Lys Trp Lys Met Arg 
1               5                   10                  15      


Arg Asn Gln Phe Trp Val Lys Val Gln Arg Gly 
            20                  25          


<210>  7
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PNC-29 (Control Peptide)

<400>  7

Met Pro Phe Ser Thr Gly Lys Arg Ile Met Leu Gly Glu Lys Lys Trp 
1               5                   10                  15      


Lys Met Arg Arg Asn Gln Phe Trp Val Lys Val Gln Arg Gly 
            20                  25                  30  


<210>  8
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PNC-27-Leupeptin


<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  acetyl moiety, CHO

<400>  8

Pro Pro Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Lys 
1               5                   10                  15      


Lys Trp Lys Met Arg Arg Asn Gln Phe Trp Val Lys Val Gln Arg Gly 
            20                  25                  30          


Leu Leu Arg Xaa 
        35      


<210>  9
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PNC-28-Leupeptin


<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  X=acetyl moiety, CHO

<400>  9

Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Lys Lys Trp Lys Met Arg 
1               5                   10                  15      


Arg Asn Gln Phe Trp Val Lys Val Gln Arg Gly Leu Leu Arg Xaa 
            20                  25                  30      


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  non-native p53


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  actyl moiety (CHO)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  alpha-amino-isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  phosphonomethyl-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  6-chlorotryptophan

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  1-amino-cyclopropanecarboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  NH2

<400>  10

Xaa Phe Met Xaa Xaa Xaa Glu Xaa Leu Xaa 
1               5                   10  


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leupeptin


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  acetyl moiety, CHO

<400>  11

Leu Leu Arg Xaa 
1               


