                         SEQUENCE LISTING

<110>  SOOD, ANIL
       LOPEZ-BERESTEIN, GABRIEL
       ARMAIZ-PENA, GUILLERMO
 
<120>  THERAPEUTIC TARGETING OF IL-6 USING siRNA IN NEUTRAL LIPOSOMES

<130>  UTFC:993WO

<140>  UNKNOWN
<141>  2008-11-25

<140>  60/990,538
<141>  2007-11-27

<160>  17    

<170>  PatentIn version 3.3

<210>  1
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  2
<211>  211
<212>  PRT
<213>  Mus musculus

<400>  2

Met Lys Phe Leu Ser Ala Arg Asp Phe His Pro Val Ala Phe Leu Gly 
1               5                   10                  15      


Leu Met Leu Val Thr Thr Thr Ala Phe Pro Thr Ser Gln Val Arg Arg 
            20                  25                  30          


Gly Asp Phe Thr Glu Asp Thr Thr Pro Asn Arg Pro Val Tyr Thr Thr 
        35                  40                  45              


Ser Gln Val Gly Gly Leu Ile Thr His Val Leu Trp Glu Ile Val Glu 
    50                  55                  60                  


Met Arg Lys Glu Leu Cys Asn Gly Asn Ser Asp Cys Met Asn Asn Asp 
65                  70                  75                  80  


Asp Ala Leu Ala Glu Asn Asn Leu Lys Leu Pro Glu Ile Gln Arg Asn 
                85                  90                  95      


Asp Gly Cys Tyr Gln Thr Gly Tyr Asn Gln Glu Ile Cys Leu Leu Lys 
            100                 105                 110         


Ile Ser Ser Gly Leu Leu Glu Tyr His Ser Tyr Leu Glu Tyr Met Lys 
        115                 120                 125             


Asn Asn Leu Lys Asp Asn Lys Lys Asp Lys Ala Arg Val Leu Gln Arg 
    130                 135                 140                 


Asp Thr Glu Thr Leu Ile His Ile Phe Asn Gln Glu Val Lys Asp Leu 
145                 150                 155                 160 


His Lys Ile Val Leu Pro Thr Pro Ile Ser Asn Ala Leu Leu Thr Asp 
                165                 170                 175     


Lys Leu Glu Ser Gln Lys Glu Trp Leu Arg Thr Lys Thr Ile Gln Phe 
            180                 185                 190         


Ile Leu Lys Ser Leu Glu Glu Phe Leu Lys Val Thr Leu Arg Ser Thr 
        195                 200                 205             


Arg Gln Thr 
    210     


<210>  3
<211>  207
<212>  PRT
<213>  Canis lupus familiaris

<400>  3

Met Asn Ser Leu Ser Thr Ser Ala Phe Ser Leu Gly Leu Leu Leu Val 
1               5                   10                  15      


Met Ala Thr Ala Phe Pro Thr Pro Gly Pro Leu Ala Gly Asp Ser Lys 
            20                  25                  30          


Asp Asp Ala Thr Ser Asn Ser Leu Pro Leu Thr Ser Ala Asn Lys Val 
        35                  40                  45              


Glu Glu Leu Ile Lys Tyr Ile Leu Gly Lys Ile Ser Ala Leu Arg Lys 
    50                  55                  60                  


Glu Met Cys Asp Lys Phe Asn Lys Cys Glu Asp Ser Lys Glu Ala Leu 
65                  70                  75                  80  


Ala Glu Asn Asn Leu His Leu Pro Lys Leu Glu Gly Lys Asp Gly Cys 
                85                  90                  95      


Phe Gln Ser Gly Phe Asn Gln Glu Thr Cys Leu Thr Arg Ile Thr Thr 
            100                 105                 110         


Gly Leu Val Glu Phe Gln Leu His Leu Asn Ile Leu Gln Asn Asn Tyr 
        115                 120                 125             


Glu Gly Asp Lys Glu Asn Val Lys Ser Val His Met Ser Thr Lys Ile 
    130                 135                 140                 


Leu Val Gln Met Leu Lys Ser Lys Val Lys Asn Gln Asp Glu Val Thr 
145                 150                 155                 160 


Thr Pro Asp Pro Thr Thr Asp Ala Ser Leu Gln Ala Ile Leu Gln Ser 
                165                 170                 175     


Gln Asp Glu Cys Val Lys His Thr Thr Ile His Leu Ile Leu Arg Ser 
            180                 185                 190         


Leu Glu Asp Phe Leu Gln Phe Ser Leu Arg Ala Val Arg Ile Met 
        195                 200                 205         


<210>  4
<211>  207
<212>  PRT
<213>  Marmota monax

<400>  4

Met Lys Phe Phe Ser Ile Ala Ser Leu Gly Leu Leu Leu Val Val Ala 
1               5                   10                  15      


Thr Ala Phe Pro Ala Ser Glu Leu Gln Arg Glu Asp Gly Glu Asn Ser 
            20                  25                  30          


Val Thr Arg Asn Lys Pro Thr Arg Ala Ser Ser Gly Lys Thr Arg Arg 
        35                  40                  45              


Gln Ile Ser Tyr Leu Ile Lys Glu Val Phe Glu Met Arg Lys Glu Leu 
    50                  55                  60                  


Cys Lys Asn Asp Glu Thr Cys Ile Lys Ser His Val Ala Val Ser Glu 
65                  70                  75                  80  


Asn Asn Leu Asn Leu Pro Lys Met Thr Glu Lys Asp Gly Cys Phe Gln 
                85                  90                  95      


Thr Gly Tyr Asn Arg Asp Asp Cys Leu Val Arg Ile Thr Ser Gly Leu 
            100                 105                 110         


Leu Glu Phe Gln Val Tyr Leu Arg Tyr Ile Arg Asn Lys Phe Gln Glu 
        115                 120                 125             


Gly Asn Asn Arg Asp Arg Ala Glu His Val Gln Ser Ser Ser Lys Ala 
    130                 135                 140                 


Leu Ile Glu Ile Leu Lys Gln Glu Val Lys Asp Pro Asn Lys Ile Val 
145                 150                 155                 160 


Phe Pro Ser Pro Thr Ala Asn Ile Asn Leu Leu Ala Lys Leu Glu Ser 
                165                 170                 175     


Gln Asn Asp Trp Gln Lys Val Met Thr Met Gln Leu Ile Leu Ser Asn 
            180                 185                 190         


Phe Glu Asp Phe Leu Gln Phe Thr Leu Arg Ala Val Arg Lys Ala 
        195                 200                 205         


<210>  5
<211>  212
<212>  PRT
<213>  Sus scrofa

<400>  5

Met Asn Ser Leu Ser Thr Ser Ala Phe Ser Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Met Ala Thr Ala Phe Pro Thr Pro Glu Arg Leu 
            20                  25                  30          


Glu Glu Asp Ala Lys Gly Asp Ala Thr Ser Asp Lys Met Leu Phe Thr 
        35                  40                  45              


Ser Pro Asp Lys Thr Glu Glu Leu Ile Lys Tyr Ile Leu Gly Lys Ile 
    50                  55                  60                  


Ser Ala Met Arg Lys Glu Met Cys Glu Lys Tyr Glu Lys Cys Glu Asn 
65                  70                  75                  80  


Ser Lys Glu Val Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Gln Glu Thr Cys Leu 
            100                 105                 110         


Met Arg Ile Thr Thr Gly Leu Val Glu Phe Gln Ile Tyr Leu Asp Tyr 
        115                 120                 125             


Leu Gln Lys Glu Tyr Glu Ser Asn Lys Gly Asn Val Glu Ala Val Gln 
    130                 135                 140                 


Ile Ser Thr Lys Ala Leu Ile Gln Thr Leu Arg Gln Lys Gly Lys Asn 
145                 150                 155                 160 


Pro Asp Lys Ala Thr Thr Pro Asn Pro Thr Thr Asn Ala Gly Leu Leu 
                165                 170                 175     


Asp Lys Leu Gln Ser Gln Asn Glu Trp Met Lys Asn Thr Lys Ile Ile 
            180                 185                 190         


Leu Ile Leu Arg Ser Leu Glu Asp Phe Leu Gln Phe Ser Leu Arg Ala 
        195                 200                 205             


Ile Arg Ile Met 
    210         


<210>  6
<211>  1131
<212>  DNA
<213>  Homo sapiens

<400>  6
cattctgccc tcgagcccac cgggaacgaa agagaagctc tatctcccct ccaggagccc     60

agctatgaac tccttctcca caagcgcctt cggtccagtt gccttctccc tggggctgct    120

cctggtgttg cctgctgcct tccctgcccc agtaccccca ggagaagatt ccaaagatgt    180

agccgcccca cacagacagc cactcacctc ttcagaacga attgacaaac aaattcggta    240

catcctcgac ggcatctcag ccctgagaaa ggagacatgt aacaagagta acatgtgtga    300

aagcagcaaa gaggcactgg cagaaaacaa cctgaacctt ccaaagatgg ctgaaaaaga    360

tggatgcttc caatctggat tcaatgagga gacttgcctg gtgaaaatca tcactggtct    420

tttggagttt gaggtatacc tagagtacct ccagaacaga tttgagagta gtgaggaaca    480

agccagagct gtgcagatga gtacaaaagt cctgatccag ttcctgcaga aaaaggcaaa    540

gaatctagat gcaataacca cccctgaccc aaccacaaat gccagcctgc tgacgaagct    600

gcaggcacag aaccagtggc tgcaggacat gacaactcat ctcattctgc gcagctttaa    660

ggagttcctg cagtccagcc tgagggctct tcggcaaatg tagcatgggc acctcagatt    720

gttgttgtta atgggcattc cttcttctgg tcagaaacct gtccactggg cacagaactt    780

atgttgttct ctatggagaa ctaaaagtat gagcgttagg acactatttt aattattttt    840

aatttattaa tatttaaata tgtgaagctg agttaattta tgtaagtcat atttatattt    900

ttaagaagta ccacttgaaa cattttatgt attagttttg aaataataat ggaaagtggc    960

tatgcagttt gaatatcctt tgtttcagag ccagatcatt tcttggaaag tgtaggctta   1020

cctcaaataa atggctaact tatacatatt tttaaagaaa tatttatatt gtatttatat   1080

aatgtataaa tggtttttat accaataaat ggcattttaa aaaattcagc a            1131


<210>  7
<211>  1087
<212>  DNA
<213>  Mus musculus

<400>  7
ccaagaacga tagtcaattc cagaaaccgc tatgaagttc ctctctgcaa gagacttcca     60

tccagttgcc ttcttgggac tgatgctggt gacaaccacg gccttcccta cttcacaagt    120

ccggagagga gacttcacag aggataccac tcccaacaga cctgtctata ccacttcaca    180

agtcggaggc ttaattacac atgttctctg ggaaatcgtg gaaatgagaa aagagttgtg    240

caatggcaat tctgattgta tgaacaacga tgatgcactt gcagaaaaca atctgaaact    300

tccagagata caaagaaatg atggatgcta ccaaactgga tataatcagg aaatttgcct    360

attgaaaatt tcctctggtc ttctggagta ccatagctac ctggagtaca tgaagaacaa    420

cttaaaagat aacaagaaag acaaagccag agtccttcag agagatacag aaactctaat    480

tcatatcttc aaccaagagg taaaagattt acataaaata gtccttccta ccccaatttc    540

caatgctctc ctaacagata agctggagtc acagaaggag tggctaagga ccaagaccat    600

ccaattcatc ttgaaatcac ttgaagaatt tctaaaagtc actttgagat ctactcggca    660

aacctagtgc gttatgccta agcatatcag tttgtggaca ttcctcactg tggtcagaaa    720

atatatcctg ttgtcaggta tctgacttat gttgttctct acgaagaact gacaatatga    780

atgttgggac actattttaa ttatttttaa tttattgata atttaaataa gtaaacttta    840

agttaattta tgattgatat ttattatttt tatgaagtgt cacttgaaat gttatatgtt    900

atagttttga aatgataacc taaaaatcta tttgatataa atattctgtt acctagccag    960

atggtttctt ggaatgtata agtttacctc aatgaattgc taatttaaat atgtttttaa   1020

agaaatcttt gtgatgtatt tttataatgt ttagactgtc ttcaaacaaa taaattatat   1080

tatattt                                                             1087


<210>  8
<211>  1104
<212>  DNA
<213>  Canis lupus familiaris

<400>  8
gccctcgagc ccaccaggaa cgaaagagag ctccatctgc cctccaggac cccagctatg     60

aactccctct ccacaagcgc cttctccctg gggctgctcc tggtgatggc tactgctttc    120

cctaccccgg gacccctggc aggagattcc aaggatgatg ccacttcaaa tagtctacca    180

ctcacctctg caaacaaagt ggaagaactg attaagtaca tcctcggcaa aatctctgca    240

ctgagaaagg agatgtgtga caagtttaac aagtgtgaag acagcaaaga ggcactggca    300

gaaaataacc tacatcttcc caaactggag ggaaaagatg gatgcttcca atctgggttc    360

aatcaggaga cctgcttgac aagaatcact accggtcttg tggagtttca gctacacctg    420

aatatcctcc agaacaacta tgagggtgat aaggaaaatg tcaagtctgt gcacatgagt    480

accaagatcc tggtccagat gctaaagagc aaggtaaaga atcaggatga agtgaccact    540

cctgacccaa ccacagacgc cagcctgcag gctatcttgc agtcgcagga tgagtgcgtg    600

aagcacacaa caattcacct catcctgcgg agtctggagg atttcctgca gttcagtctg    660

agggctgttc ggataatgta gcctgggcat ctaagattgc tgtagttcat gggcattcct    720

ttctccagtc agaaacctgt gcagtgggca caaaacttat gttgttctct gtgaggaact    780

aaaagtatga gcgttaggac actattttaa ttatttttaa tttattgata tttaaatatg    840

tgatatggag ttaatttata taagtaatag atatttatat tttttatgaa gtgccacttg    900

aaatatttta tgtattcatt ttgaaaaagt taacgtaaaa tgctatgcgg cttgaatatc    960

ctcgatgttt cggagccagg tcatttcttg gaatgtgtag gtttacctca aatacatggc   1020

taacttatgc atatttttaa aagaaatatt tatactgtgt ttatataatg tttaaattgt   1080

ttttatacca ataaacacct tttt                                          1104


<210>  9
<211>  756
<212>  DNA
<213>  Marmota monax

<400>  9
caactccatc tgcccttcag gaacagccat gaagttcttc tcaattgcct ccttggggct     60

gctcctagtg gtggctactg ccttccccgc ctcagaactt cagagagaag atggagagaa    120

tagtgttact cgaaataaac caacacgtgc ctcttctgga aaaactcgca gacagatttc    180

ctacctcatc aaggaagtct tcgaaatgag aaaagagctg tgcaagaatg atgagacctg    240

tattaagagc catgtggcag tgtccgaaaa caatctgaac cttccaaaga tgactgaaaa    300

agatggatgc ttccaaactg gatacaatcg ggacgactgc cttgtgcgaa tcacctctgg    360

gcttctggag tttcaggtct acctgaggta catccggaac aagtttcagg aaggcaataa    420

cagggacaga gctgaacatg tgcagtccag ttccaaagcc ctgattgaga tcctgaaaca    480

agaggtgaag gatcccaata aaatagtctt ccctagccca actgcaaata tcaacctatt    540

ggcaaaactg gagtcacaga atgattggca gaaggtcatg accatgcaac tcatcttgag    600

caactttgag gatttcctgc agttcaccct gagagctgtt cggaaagcat agtgggcatc    660

taagcttatt ggttcatggg cattgcttcc tatggtcaga aaacatgtcc tgtccactgg    720

gtacctacct tatgttgttc tctacgaaga actggc                              756


<210>  10
<211>  1123
<212>  DNA
<213>  Sus scrofa

<400>  10
cagtctgccc tcgagcccac caggaacgaa agagagctcc atctgccctc caggaaccca     60

gctatgaact ccctctccac aagcgccttc agtccagtcg ccttctccct ggggctgctt    120

ctggtgatgg ctactgcctt ccctaccccg ggacgcctgg aagaagatgc caaaggtgat    180

gccacctcag acaaaatgct cttcacctct ccggacaaaa ctgaagaact cattaagtac    240

atcctcggca aaatctctgc aatgagaaag gagatgtgtg agaagtatga gaagtgtgaa    300

aacagcaagg aggtactggc agaaaacaac ctgaaccttc caaaaatggc agaaaaagac    360

ggatgcttcc aatctgggtt caatcaggag acctgcttga tgagaatcac caccggtctt    420

gtggagtttc agatatacct ggactacctc cagaaagagt atgagagcaa taagggaaat    480

gtcgaggctg tgcagattag taccaaagca ctgatccaga ccctgaggca aaagggaaag    540

aatccagaca aagccaccac ccctaacccc accacaaatg ccggcctgct ggataagctg    600

cagtcacaga acgagtggat gaagaacaca aagatcattc tcatcctgcg cagccttgag    660

gatttcctgc agttcagcct gagggccatt cggataatgt agctggggca cctgagattg    720

atgccgtcca cgggcattcc ctcctctggt cagaaacctg tccactgggc acataactta    780

tgttgttctc tatgaagaac taaaagtatg agcgttagga cactatttta attattttaa    840

tttattgata tttaaatatg tgatgtcgag ttaatttata taagtgatag atatttatat    900

ttttattaag tgccacttga aatattttat gtatttgttt tgaaaaagta acgtaaaatg    960

gctacacggc ttgaagatcc ttgttgtttc agagccaggt tgtttcttgg agtgtgtagg   1020

cttacctcaa ataaattgct aacttatacg tatttttaaa agaaatattt atattgtatt   1080

tatataaagt ttaagttgtt tttataccaa taaacacctt ttt                     1123


<210>  11
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  11
gaaggtgaag gtcggagtc                                                  19


<210>  12
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  12
gaagatggtg atgggatttc                                                 20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  13
caagcttccc gttctcagcc                                                 20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  14
gtgtgaagca gcaaagaagc                                                 20


<210>  15
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  15
ctggaggtac tctaggtata c                                               21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  16
ggattcaatg aggagacttg c                                               21


<210>  17
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  17
cccaggagaa gauuccaaag augua                                           25


