                         SEQUENCE LISTING

<110>  AMGEN INC.
 
<120>  WISE BINDING AGENTS AND EPITOPES

<130>  A-1378-WO-PCT

<140>  Not Yet Assigned
<141>  2008-11-20

<150>  61/004,037
<151>  2007-11-21

<160>  282   

<170>  PatentIn version 3.3

<210>  1
<211>  673
<212>  DNA
<213>  Homo sapiens

<400>  1
atgcttcctc ctgccattca tttctatctc cttccccttg catgcatcct aatgaaaagc     60

tgtttggctt ttaaaaatga tgccacagaa atcctttatt cacatgtggt taaacctgtt    120

ccagcacacc ccagcagcaa cagcacgttg aatcaagcca gaaatggagg caggcatttc    180

agtaacactg gactggatcg gaacactcgg gttcaagtgg gttgccggga actgcgttcc    240

accaaataca tctctgatgg ccagtgcacc agcatcagcc ctctgaagga gctggtgtgt    300

gctggcgagt gcttgcccct gccagtgctc cctaactgga ttggaggagg ctatggaaca    360

aagtactgga gcaggaggag ctcccaggag tggcggtgtg tcaatgacaa aacccgtacc    420

cagagaatcc agctgcagtg ccaagatggc agcacacgca cctacaaaat cacagtagtc    480

actgcctgca agtgcaagag gtacacccgg cagcacaacg agtccagtca caactttgag    540

agcatgtcac ctgccaagcc agtccagcat cacagagagc ggaaaagagc cagcaaatcc    600

agcaagcaca gcatgagtta gctcgagggg cggatccccc gggctgcagg aattcgatat    660

caagcttgct agc                                                       673


<210>  2
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Pro Pro Ala Ile His Phe Tyr Leu Leu Pro Leu Ala Cys Ile 
1               5                   10                  15      


Leu Met Lys Ser Cys Leu Ala Phe Lys Asn Asp Ala Thr Glu Ile Leu 
            20                  25                  30          


Tyr Ser His Val Val Lys Pro Val Pro Ala His Pro Ser Ser Asn Ser 
        35                  40                  45              


Thr Leu Asn Gln Ala Arg Asn Gly Gly Arg His Phe Ser Asn Thr Gly 
    50                  55                  60                  


Leu Asp Arg Asn Thr Arg Val Gln Val Gly Cys Arg Glu Leu Arg Ser 
65                  70                  75                  80  


Thr Lys Tyr Ile Ser Asp Gly Gln Cys Thr Ser Ile Ser Pro Leu Lys 
                85                  90                  95      


Glu Leu Val Cys Ala Gly Glu Cys Leu Pro Leu Pro Val Leu Pro Asn 
            100                 105                 110         


Trp Ile Gly Gly Gly Tyr Gly Thr Lys Tyr Trp Ser Arg Arg Ser Ser 
        115                 120                 125             


Gln Glu Trp Arg Cys Val Asn Asp Lys Thr Arg Thr Gln Arg Ile Gln 
    130                 135                 140                 


Leu Gln Cys Gln Asp Gly Ser Thr Arg Thr Tyr Lys Ile Thr Val Val 
145                 150                 155                 160 


Thr Ala Cys Lys Cys Lys Arg Tyr Thr Arg Gln His Asn Glu Ser Ser 
                165                 170                 175     


His Asn Phe Glu Ser Met Ser Pro Ala Lys Pro Val Gln His His Arg 
            180                 185                 190         


Glu Arg Lys Arg Ala Ser Lys Ser Ser Lys His Ser Met Ser 
        195                 200                 205     


<210>  3
<211>  627
<212>  DNA
<213>  Mus musculus

<400>  3
atgcttcctc ctgccattca tctctctctc attcccctgc tctgcatcct gatgagaaac     60

tgtttggctt ttaaaaatga tgccacagaa atcctttatt cacatgtggt taaacctgtc    120

ccggcacacc ccagcagcaa cagcaccctg aatcaagcca ggaatggagg caggcatttc    180

agtagcactg gactggatcg aaacagtcga gttcaagtgg gctgcaggga actgcggtcc    240

accaaataca tttcggacgg ccagtgcacc agcatcagcc ctctgaagga gctggtgtgc    300

gcgggcgagt gcttgcccct gccggtgctt cccaactgga tcggaggagg ctatggaaca    360

aagtactgga gccggaggag ctctcaggag tggcggtgtg tcaacgacaa gacgcgcacc    420

cagaggatcc agctgcagtg tcaggacggc agcacgcgca cctacaaaat caccgtggtc    480

acggcgtgca agtgcaagag gtacacccgt cagcacaacg agtccagcca caactttgaa    540

agcgtgtcgc ccgccaagcc cgcccagcac cacagagagc ggaagagagc cagcaaatcc    600

agcaagcaca gtctgagcta gctcgag                                        627


<210>  4
<211>  206
<212>  PRT
<213>  Mus musculus

<400>  4

Met Leu Pro Pro Ala Ile His Leu Ser Leu Ile Pro Leu Leu Cys Ile 
1               5                   10                  15      


Leu Met Arg Asn Cys Leu Ala Phe Lys Asn Asp Ala Thr Glu Ile Leu 
            20                  25                  30          


Tyr Ser His Val Val Lys Pro Val Pro Ala His Pro Ser Ser Asn Ser 
        35                  40                  45              


Thr Leu Asn Gln Ala Arg Asn Gly Gly Arg His Phe Ser Ser Thr Gly 
    50                  55                  60                  


Leu Asp Arg Asn Ser Arg Val Gln Val Gly Cys Arg Glu Leu Arg Ser 
65                  70                  75                  80  


Thr Lys Tyr Ile Ser Asp Gly Gln Cys Thr Ser Ile Ser Pro Leu Lys 
                85                  90                  95      


Glu Leu Val Cys Ala Gly Glu Cys Leu Pro Leu Pro Val Leu Pro Asn 
            100                 105                 110         


Trp Ile Gly Gly Gly Tyr Gly Thr Lys Tyr Trp Ser Arg Arg Ser Ser 
        115                 120                 125             


Gln Glu Trp Arg Cys Val Asn Asp Lys Thr Arg Thr Gln Arg Ile Gln 
    130                 135                 140                 


Leu Gln Cys Gln Asp Gly Ser Thr Arg Thr Tyr Lys Ile Thr Val Val 
145                 150                 155                 160 


Thr Ala Cys Lys Cys Lys Arg Tyr Thr Arg Gln His Asn Glu Ser Ser 
                165                 170                 175     


His Asn Phe Glu Ser Val Ser Pro Ala Lys Pro Ala Gln His His Arg 
            180                 185                 190         


Glu Arg Lys Arg Ala Ser Lys Ser Ser Lys His Ser Leu Ser 
        195                 200                 205     


<210>  5
<211>  629
<212>  DNA
<213>  Rattus norvegicus

<400>  5
atgcttcctc ctgccattca tctctctctc attcccctgc tctgcatcct gatgaaaaac     60

tgtttggctt ttaaaaatga tgccacagaa atcctttatt cacatgtggt taaacctgtt    120

tcagcacacc ccagcagcaa cagcaccttg aatcaagcca ggaatggagg caggcacttc    180

agtagcacgg gactggatcg aaatagtcga gttcaagtgg gctgcaggga actgcggtcc    240

accaaataca tctcggatgg ccagtgcacc agcatcagcc ctctgaagga gctggtgtgc    300

gcgggtgagt gcttgccctt gccagtgctt cccaactgga tcggaggagg ctacggaaca    360

aagtactgga gccggaggag ctcccaggag tggcggtgtg tcaacgacaa gacgcgcacc    420

cagagaatcc agctgcagtg tcaggacggc agcacacgca cctacaaaat caccgtggtc    480

acagcgtgca agtgcaagag gtacacccgg cagcacaacg agtccagcca caactttgaa    540

agcgtgtctc ccgccaagcc cgcccagcac cacagagagc ggaagagagc cagcaaatcc    600

agcaagcaca gtctgagcta ggcggccgc                                      629


<210>  6
<211>  206
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Leu Pro Pro Ala Ile His Phe Tyr Leu Leu Pro Leu Ala Cys Ile 
1               5                   10                  15      


Leu Met Lys Ser Cys Leu Ala Phe Lys Asn Asp Ala Thr Glu Ile Leu 
            20                  25                  30          


Tyr Ser His Val Val Lys Pro Val Pro Ala His Pro Ser Ser Asn Ser 
        35                  40                  45              


Thr Met Asn Gln Ala Arg Asn Gly Gly Arg His Phe Ser Asn Thr Gly 
    50                  55                  60                  


Leu Asp Arg Asn Thr Arg Val Gln Val Gly Cys Arg Glu Leu Arg Ser 
65                  70                  75                  80  


Thr Lys Tyr Ile Ser Asp Gly Gln Cys Thr Ser Ile Ser Pro Leu Lys 
                85                  90                  95      


Glu Leu Val Cys Ala Gly Glu Cys Leu Pro Leu Pro Val Leu Pro Asn 
            100                 105                 110         


Trp Ile Gly Gly Gly Tyr Gly Thr Lys Tyr Trp Ser Arg Arg Ser Ser 
        115                 120                 125             


Gln Glu Trp Arg Cys Val Asn Asp Lys Thr Arg Thr Gln Arg Ile Gln 
    130                 135                 140                 


Leu Gln Cys Gln Asp Gly Ser Thr Arg Thr Tyr Lys Ile Thr Val Val 
145                 150                 155                 160 


Thr Ala Cys Lys Cys Lys Arg Tyr Thr Arg Gln His Asn Glu Ser Ser 
                165                 170                 175     


His Asn Phe Glu Ser Met Ser Pro Ala Lys Pro Val Gln His His Arg 
            180                 185                 190         


Glu Arg Lys Arg Ala Ser Lys Ser Ser Lys His Ser Met Ser 
        195                 200                 205     


<210>  7
<211>  629
<212>  DNA
<213>  Macaca fascicularis

<400>  7
atgcttcctc ctgccattca tctctctctc attcccctgc tctgcatcct gatgaaaaac     60

tgtttggctt ttaaaaatga tgccacagaa atcctttatt cacatgtggt taaacctgtt    120

tcagcacacc ccagcagcaa cagcaccttg aatcaagcca ggaatggagg caggcacttc    180

agtagcacgg gactggatcg aaatagtcga gttcaagtgg gctgcaggga actgcggtcc    240

accaaataca tctcggatgg ccagtgcacc agcatcagcc ctctgaagga gctggtgtgc    300

gcgggtgagt gcttgccctt gccagtgctt cccaactgga tcggaggagg ctacggaaca    360

aagtactgga gccggaggag ctcccaggag tggcggtgtg tcaacgacaa gacgcgcacc    420

cagagaatcc agctgcagtg tcaggacggc agcacacgca cctacaaaat caccgtggtc    480

acagcgtgca agtgcaagag gtacacccgg cagcacaacg agtccagcca caactttgaa    540

agcgtgtctc ccgccaagcc cgcccagcac cacagagagc ggaagagagc cagcaaatcc    600

agcaagcaca gtctgagcta ggcggccgc                                      629


<210>  8
<211>  206
<212>  PRT
<213>  Macaca fascicularis

<400>  8

Met Leu Pro Pro Ala Ile His Leu Ser Leu Ile Pro Leu Leu Cys Ile 
1               5                   10                  15      


Leu Met Lys Asn Cys Leu Ala Phe Lys Asn Asp Ala Thr Glu Ile Leu 
            20                  25                  30          


Tyr Ser His Val Val Lys Pro Val Ser Ala His Pro Ser Ser Asn Ser 
        35                  40                  45              


Thr Leu Asn Gln Ala Arg Asn Gly Gly Arg His Phe Ser Ser Thr Gly 
    50                  55                  60                  


Leu Asp Arg Asn Ser Arg Val Gln Val Gly Cys Arg Glu Leu Arg Ser 
65                  70                  75                  80  


Thr Lys Tyr Ile Ser Asp Gly Gln Cys Thr Ser Ile Ser Pro Leu Lys 
                85                  90                  95      


Glu Leu Val Cys Ala Gly Glu Cys Leu Pro Leu Pro Val Leu Pro Asn 
            100                 105                 110         


Trp Ile Gly Gly Gly Tyr Gly Thr Lys Tyr Trp Ser Arg Arg Ser Ser 
        115                 120                 125             


Gln Glu Trp Arg Cys Val Asn Asp Lys Thr Arg Thr Gln Arg Ile Gln 
    130                 135                 140                 


Leu Gln Cys Gln Asp Gly Ser Thr Arg Thr Tyr Lys Ile Thr Val Val 
145                 150                 155                 160 


Thr Ala Cys Lys Cys Lys Arg Tyr Thr Arg Gln His Asn Glu Ser Ser 
                165                 170                 175     


His Asn Phe Glu Ser Val Ser Pro Ala Lys Pro Ala Gln His His Arg 
            180                 185                 190         


Glu Arg Lys Arg Ala Ser Lys Ser Ser Lys His Ser Leu Ser 
        195                 200                 205     


<210>  9
<211>  714
<212>  DNA
<213>  Homo sapiens

<400>  9
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat     60

gttgtgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc    120

tcttgcagat ctagtcagag ccttgaacac agtaatggaa acacctattt acattggtac    180

ctgcagaagc caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct    240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc    300

agagtggagg ctgaggatct gggagtttat ttctgctctc aaagtacaca tgttccgctc    360

acgttcggtg ctgggaccaa ggtggagctg aaacgggctg atgctgcacc aactgtatcc    420

atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg    480

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa    540

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc    600

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc    660

actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgt          714


<210>  10
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Glu His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Ser Gln Ser Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Val 
        115                 120                 125             


Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  11
<211>  1428
<212>  DNA
<213>  Mus musculus

<400>  11
atgggttggc tgtggaactt gctattcctg atggcagctg cccaaagtgc ccaagcacag     60

atccacttgg tacagtctgg acctgagctg aagaagcctg gagagactgt caagatctcc    120

tgcaaggcgt ctgggttttc cttcacaacc tatggaatga gctgggtgaa acaggctcca    180

ggaaagggtt taaagtggat gggctggata aatacctact ctggagtgcc tacatatgct    240

gatgacttca agggacggtt tgccttctct ttggaaacct ctgccagcac tgcctatttg    300

cagatcaaca acctcaaaaa tgaggacacg gctacatatt tctgtgtaag ggggagggaa    360

tattactacg gtagtggcat tgctttctgg ggccaaggga ctctggtcac tgtctctgca    420

gccaaaacaa cacccccatc agtctatcca ctggcccctg ggtgtggaga tacaactggt    480

tcctctgtga ctctgggatg cctggtcaag ggctacttcc ctgagtcagt gactgtgact    540

tggaactctg gatccctgtc cagcagtgtg cacaccttcc cagctctcct gcagtctgga    600

ctctacacta tgagcagctc agtgactgtc ccctccagca cctggccaag tcagaccgtc    660

acctgcagcg ttgctcaccc agccagcagc accacggtgg acaaaaaact tgagcccagc    720

gggcccattt caacaatcaa cccctgtcct ccatgcaagg agtgtcacaa atgcccagct    780

cctaacctcg agggtggacc atccgtcttc atcttccctc caaatatcaa ggatgtactc    840

atgatctccc tgacacccaa ggtcacgtgt gtggtggtgg atgtgagcga ggatgaccca    900

gacgtccgga tcagctggtt tgtgaacaac gtggaagtac acacagctca gacacaaacc    960

catagagagg attacaacag tactatccgg gtggtcagtg ccctccccat ccagcaccag   1020

gactggatga gtggcaagga gttcaaatgc aaggtcaaca acaaagacct cccatcaccc   1080

atcgagagaa ccatctcaaa aattaaaggg ctagtcagag ctccacaagt atacatcttg   1140

ccgccaccag cagagcagtt gtccaggaaa gatgtcagtc tcacttgcct ggtcgtgggc   1200

ttcaaccctg gagacatcag tgtggagtgg accagcaatg ggcatacaga ggagaactac   1260

aaggacaccg caccagtcct ggactctgac ggttcttact tcatatacag caagctcgat   1320

ataaaaacaa gcaagtggga gaaaacagat tccttctcat gcaacgtgag acacgagggt   1380

ctgaaaaatt actacctgaa gaagaccatc tcccggtctc cgggtaaa                1428


<210>  12
<211>  476
<212>  PRT
<213>  Mus musculus

<400>  12

Met Gly Trp Leu Trp Asn Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Ala Gln Ile His Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Ser Phe 
        35                  40                  45              


Thr Thr Tyr Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Val Arg Gly Arg Glu Tyr Tyr Tyr Gly Ser Gly Ile Ala 
        115                 120                 125             


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr 
    130                 135                 140                 


Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Cys Gly Asp Thr Thr Gly 
145                 150                 155                 160 


Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Ser 
                165                 170                 175     


Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Ser Val His Thr 
            180                 185                 190         


Phe Pro Ala Leu Leu Gln Ser Gly Leu Tyr Thr Met Ser Ser Ser Val 
        195                 200                 205             


Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Ser Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Thr Val Asp Lys Lys Leu Glu Pro Ser 
225                 230                 235                 240 


Gly Pro Ile Ser Thr Ile Asn Pro Cys Pro Pro Cys Lys Glu Cys His 
                245                 250                 255     


Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe 
            260                 265                 270         


Pro Pro Asn Ile Lys Asp Val Leu Met Ile Ser Leu Thr Pro Lys Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Arg Ile 
    290                 295                 300                 


Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr 
305                 310                 315                 320 


His Arg Glu Asp Tyr Asn Ser Thr Ile Arg Val Val Ser Ala Leu Pro 
                325                 330                 335     


Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val 
            340                 345                 350         


Asn Asn Lys Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ile 
        355                 360                 365             


Lys Gly Leu Val Arg Ala Pro Gln Val Tyr Ile Leu Pro Pro Pro Ala 
    370                 375                 380                 


Glu Gln Leu Ser Arg Lys Asp Val Ser Leu Thr Cys Leu Val Val Gly 
385                 390                 395                 400 


Phe Asn Pro Gly Asp Ile Ser Val Glu Trp Thr Ser Asn Gly His Thr 
                405                 410                 415     


Glu Glu Asn Tyr Lys Asp Thr Ala Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Tyr Phe Ile Tyr Ser Lys Leu Asp Ile Lys Thr Ser Lys Trp Glu Lys 
        435                 440                 445             


Thr Asp Ser Phe Ser Cys Asn Val Arg His Glu Gly Leu Lys Asn Tyr 
    450                 455                 460                 


Tyr Leu Lys Lys Thr Ile Ser Arg Ser Pro Gly Lys 
465                 470                 475     


<210>  13
<211>  1044
<212>  DNA
<213>  Homo sapiens

<400>  13
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgcgatg tagttatgac acagtctccc ctgtctttgc cagtcacatt gggtcagccc    120

gcctctatta gctgccgaag ttctcagtct ttggagcatt ccaacggcaa tacttacttg    180

cactggtatc tgcagaagcc cggacaaagc ccccaacttc tcatctataa agtcagcaat    240

aggttcagcg gggtgcctga taggttctcc ggctccggca gcggcactga ttttaccctt    300

aaaatcagtc gggtcgaagc tgaagatgta ggcgtgtact tttgctcaca gtccacacac    360

gtacccctga cttttggagg tggaacgaaa gtggagatca aacgtacggt ggctgcacca    420

tctgtcttca tcttcccgcc atctgatgag cagttgaaat ctggaactgc ctctgttgtg    480

tgcctgctga ataacttcta tcccagagag gccaaagtac agtggaaggt ggataacgcc    540

ctccaatcgg gtaactccca ggagagtgtc acagagcagg acagcaagga cagcacctac    600

agcctcagca gcaccctgac gctgagcaaa gcagactacg agaaacacaa agtctacgcc    660

tgcgaagtca cccatcaggg cctgagctcg cccgtcacaa agagcttcaa caggggagag    720

tgtcgtacgg tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa    780

tctggaactg cctctgttgt gtgcctgctg aataacttct atcccagaga ggccaaagta    840

cagtggaagg tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag    900

gacagcaagg acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac    960

gagaaacaca aagtctacgc ctgcgaagtc acccatcagg gcctgagctc gcccgtcaca   1020

aagagcttca acaggggaga gtgt                                          1044


<210>  14
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Val Val Met Thr Gln Ser Pro Leu Ser 
            20                  25                  30          


Leu Pro Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              


Gln Ser Leu Glu His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 
65                  70                  75                  80  


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
            100                 105                 110         


Tyr Phe Cys Ser Gln Ser Thr His Val Pro Leu Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
    130                 135                 140                 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
145                 150                 155                 160 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
                165                 170                 175     


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
    210                 215                 220                 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
225                 230                 235                 240 


Cys 
    


<210>  15
<211>  1407
<212>  DNA
<213>  Homo sapiens

<400>  15
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgccagg tgcagctcgt gcaaagtggg gccgaagtga aaaaacctgg agcaagcgtt    120

aaagtgtcct gcaaagcgtc tggctacacc tttactacct atggaatgtc atgggtgaaa    180

caagcacccg gccaaggtct ggagtggatg ggttggataa acacatattc cggcgtcccc    240

acctatgcag acgactttaa aggccgcttc gtgttctccc ttgacacctc tgtaagtacc    300

gcgtatctgc aaatcaattc cctgaaagcc gaggacactg ccgtgtactt ttgcgtgcgg    360

ggccgagaat actactatgg cagcggcata gccttttggg gtcaggggac cctggtgacc    420

gtctctagtg cctccaccaa gggcccatcg gtcttccccc tggcgccctg ctccaggagc    480

acctccgaga gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg    540

acggtgtcgt ggaactcagg cgctctgacc agcggcgtgc acaccttccc agctgtccta    600

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag caacttcggc    660

acccagacct acacctgcaa cgtagatcac aagcccagca acaccaaggt ggacaagaca    720

gttgagcgca aatgttgtgt cgagtgccca ccgtgcccag caccacctgt ggcaggaccg    780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag    840

gtcacgtgcg tggtggtgga cgtgagccac gaagaccccg aggtccagtt caactggtac    900

gtggacggcg tggaggtgca taatgccaag acaaagccac gggaggagca gttcaacagc    960

acgttccgtg tggtcagcgt cctcaccgtt gtgcaccagg actggctgaa cggcaaggag   1020

tacaagtgca aggtctccaa caaaggcctc ccagccccca tcgagaaaac catctccaaa   1080

accaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg   1140

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc   1200

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacacc tcccatgctg   1260

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag   1320

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag   1380

aagagcctct ccctgtctcc gggtaaa                                       1407


<210>  16
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Thr Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Val Phe Ser Leu Asp Thr 
                85                  90                  95      


Ser Val Ser Thr Ala Tyr Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Glu Tyr Tyr Tyr Gly Ser 
        115                 120                 125             


Gly Ile Ala Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
145                 150                 155                 160 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr 
225                 230                 235                 240 


Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
305                 310                 315                 320 


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  17
<211>  714
<212>  DNA
<213>  Homo sapiens

<400>  17
atggagaaag acacactcct gctatgggtc ctgcttctct gggttccagg gtccacaggt     60

gacattgtgc tgacccaatc tccaccttct ttggctgtgt ctctagggca gagggccacc    120

atctcctgca gagccagcga aagtgttgat aattatggct ctagttttat gaactggttc    180

caacagaaac caggacagcc acccaaactc ctcatctttg ctgcatccaa ccaaggatcc    240

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat    300

cctatggagg aggatgatgc tgcaatgtat ttctgtcagc aaagtaagga ggttccgtac    360

acgttcggag gggggaccaa actggaaata aaacgggctg atgctgcacc aactgtatcc    420

atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg    480

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa    540

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc    600

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc    660

actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgt          714


<210>  18
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Lys Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Asn Tyr Gly Ser Ser Phe Met Asn Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Phe Ala Ala Ser Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
                85                  90                  95      


Leu Asn Ile His Pro Met Glu Glu Asp Asp Ala Ala Met Tyr Phe Cys 
            100                 105                 110         


Gln Gln Ser Lys Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  19
<211>  1419
<212>  DNA
<213>  Mus musculus

<400>  19
atggaatgga actgggtcgt tctcttcctc ctgtcattaa ctgcaggtgt ctatgcccag     60

ggtcagatgc agcagtctgg agctgagctg gtgaagcctg gggcttcagt gcaactgtcc    120

tgcaagactt ctggcttcac cttcagcagt acctatataa gttggttgaa gcagaagcct    180

ggacagagtc ttgagtggat tgcatggatt tatgctggca ctggtggtac cagatataat    240

cggaagttca caggcaaggc ccaactgact gtagacacat cctccagcac agcctacatg    300

caattcagca gcctgacaac tgaggactct gccatctatt actgtgcaag agagggggtc    360

gacgggtggt ttacttactg gggccagggg actctggtca ctgtctctgc agccaaaaca    420

acacccccat cagtctatcc actggcccct gggtgtggag atacaactgg ttcctccgtg    480

actctgggat gcctggtcaa gggctacttc cctgagtcag tgactgtgac ttggaactct    540

ggatccctgt ccagcagtgt gcacaccttc ccagctctcc tgcagtctgg actctacact    600

atgagcagct cagtgactgt cccctccagc acctggccaa gtcagaccgt cacctgcagc    660

gttgctcacc cagccagcag caccacggtg gacaaaaaac ttgagcccag cgggcccatt    720

tcaacaatca acccctgtcc tccatgcaag gagtgtcaca aatgcccagc tcctaacctc    780

gagggtggac catccgtctt catcttccct ccaaatatca aggatgtact catgatctcc    840

ctgacaccca aggtcacgtg tgtggtggtg gatgtgagcg aggatgaccc agacgtccag    900

atcagctggt ttgtgaacaa cgtggaagta cacacagctc agacacaaac ccatagagag    960

gattacaaca gtactatccg ggtggtcagc accctcccca tccagcacca ggactggatg   1020

agtggcaagg agttcaaatg caaggtcaac aacaaagacc tcccatcacc catcgagaga   1080

accatctcaa aacccaaagg gctagtcaga gctccacaag tatacacttt gccgccacca   1140

gcagagcagt tgtccaggaa agatgtcagt ctcacttgcc tggtcgtggg cttcaaccct   1200

ggagacatca gtgtggagtg gaccagcaat gggcatacag aggagaacta caaggacacc   1260

gcaccagttc ttgactctga cggttcttac ttcatatata gcaagctcaa tatgaaaaca   1320

agcaagtggg agaaaacaga ttccttctca tgcaacgtga gacacgaggg tctgaaaaat   1380

tactacctga agaagaccat ctcccggtct ccgggtaaa                          1419


<210>  20
<211>  473
<212>  PRT
<213>  Mus musculus

<400>  20

Met Glu Trp Asn Trp Val Val Leu Phe Leu Leu Ser Leu Thr Ala Gly 
1               5                   10                  15      


Val Tyr Ala Gln Gly Gln Met Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Gln Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Thr Tyr Ile Ser Trp Leu Lys Gln Lys Pro Gly Gln Ser Leu 
    50                  55                  60                  


Glu Trp Ile Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Arg Lys Phe Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Phe Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly Val Asp Gly Trp Phe Thr Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Gly Cys Gly Asp Thr Thr Gly Ser Ser Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Ser Val Thr Val 
                165                 170                 175     


Thr Trp Asn Ser Gly Ser Leu Ser Ser Ser Val His Thr Phe Pro Ala 
            180                 185                 190         


Leu Leu Gln Ser Gly Leu Tyr Thr Met Ser Ser Ser Val Thr Val Pro 
        195                 200                 205             


Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Ser Val Ala His Pro 
    210                 215                 220                 


Ala Ser Ser Thr Thr Val Asp Lys Lys Leu Glu Pro Ser Gly Pro Ile 
225                 230                 235                 240 


Ser Thr Ile Asn Pro Cys Pro Pro Cys Lys Glu Cys His Lys Cys Pro 
                245                 250                 255     


Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn 
            260                 265                 270         


Ile Lys Asp Val Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    290                 295                 300                 


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
305                 310                 315                 320 


Asp Tyr Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Gln His 
                325                 330                 335     


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            340                 345                 350         


Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Leu 
        355                 360                 365             


Val Arg Ala Pro Gln Val Tyr Thr Leu Pro Pro Pro Ala Glu Gln Leu 
    370                 375                 380                 


Ser Arg Lys Asp Val Ser Leu Thr Cys Leu Val Val Gly Phe Asn Pro 
385                 390                 395                 400 


Gly Asp Ile Ser Val Glu Trp Thr Ser Asn Gly His Thr Glu Glu Asn 
                405                 410                 415     


Tyr Lys Asp Thr Ala Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile 
            420                 425                 430         


Tyr Ser Lys Leu Asn Met Lys Thr Ser Lys Trp Glu Lys Thr Asp Ser 
        435                 440                 445             


Phe Ser Cys Asn Val Arg His Glu Gly Leu Lys Asn Tyr Tyr Leu Lys 
    450                 455                 460                 


Lys Thr Ile Ser Arg Ser Pro Gly Lys 
465                 470             


<210>  21
<211>  720
<212>  DNA
<213>  Homo sapiens

<400>  21
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtgaca ttcagatgac tcagtccccc tcctctctct ccgcttcagt cggggacaga    120

gtgactatca gctgccgagc cagtgagtca gtcgataatt atggctcatc cttcatgaat    180

tggtatcagc agaagccggg aaaagcccca aagctcctca tttacgccgc ttcaaaccag    240

ggttcagggg ttccctcccg cttctccggc tctgggtctg gcactgattt tacactgact    300

attagctccc tccagcctga agactttgct acctattatt gccagcagag caaagaggtc    360

ccctatacct tcggacaggg tactaaactg gagattaaac gtacggtggc tgcaccatct    420

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc    480

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc    540

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc    600

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc    660

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt    720


<210>  22
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Glu Ser Val Asp Asn Tyr Gly Ser Ser Phe Met Asn Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln 
65                  70                  75                  80  


Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Ser Lys Glu Val Pro Tyr Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  23
<211>  1398
<212>  DNA
<213>  Homo sapiens

<400>  23
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtcagg ttcagctggt gcagtctgga gccgaggtca agaagcctgg aagctctgta    120

aaggtgtcat gcaaggctag cggcggcacg ttctcttcaa catacatctc ttgggttcgg    180

caggctccag ggcaagggct ggagtggatg gggtggattt acgccggaac aggaggtacg    240

cgctacaata ggaagttcac gggaagggtg acaatcactg ctgacgaatc cacttctacc    300

gcctatatgg aactgtcctc tttgcggtcc gaggacacag ccgtgtacta ttgtgctcgg    360

gagggagtcg atggttggtt tacttattgg ggccagggta ctctcgtaac cgtctctagt    420

gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag    480

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    540

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca    600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc    660

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc    720

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc    780

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc    840

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc    900

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt    960

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc   1020

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg   1080

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac   1140

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg   1200

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac   1260

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac   1320

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc   1380

tccctgtctc cgggtaaa                                                 1398


<210>  24
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Gly Thr Phe Ser Ser Thr Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Tyr Ala Gly Thr Gly Gly Thr 
65                  70                  75                  80  


Arg Tyr Asn Arg Lys Phe Thr Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Val Asp Gly Trp Phe Thr 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  25
<211>  714
<212>  DNA
<213>  Mus musculus

<400>  25
atggagaaag acacactcct gctatgggtc ctgcttctct gggttccagg ttccacaggt     60

gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc    120

atctcctgca gagccagcga aagtgttgat aattatggca ttagttttat gaactggttc    180

caacagaaac caggacagcc acccaaactc ctcatctatg atgcatccaa ccaaggatac    240

ggggtccctg ccaggtttag tgccagtggg tctgggacag acttcagcct caacatccat    300

cctatggagg aggatgatat tgcaatgtat ttctgtcagc aaagtaagga ggttccgtac    360

acgttcggag gggggaccaa actggaaata aaacgggctg atgctgcacc aactgtatcc    420

atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg    480

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa    540

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc    600

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc    660

actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgt          714


<210>  26
<211>  240
<212>  PRT
<213>  Mus musculus

<400>  26

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Val Leu Thr Gln Ser Pro Ala Ser 
            20                  25                  30          


Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Gln 
65                  70                  75                  80  


Gly Tyr Gly Val Pro Ala Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Ser Leu Asn Ile His Pro Met Glu Glu Asp Asp Ile Ala Met Tyr 
            100                 105                 110         


Phe Cys Gln Gln Ser Lys Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys 
145                 150                 155                 160 


Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile 
                165                 170                 175     


Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr 
        195                 200                 205             


Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His 
    210                 215                 220                 


Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 240 


<210>  27
<211>  1383
<212>  DNA
<213>  Mus musculus

<400>  27
atggaatgga actgggtcgt tctcttcctc ctgtcattaa ctgcaggtgt ctatgcccag     60

ggtcagatgc agcagtctgg agctgagctg gtgaagcctg gggcttcagt gaagctgtcc    120

tgcaagactt ctggcttcac cttcaacagt cactatataa gttggttgaa gcaaaagcct    180

ggacagactc ttgagtggat tgcatggatt tatgctggaa ctggtggtac taggtataat    240

cagaagttca caggcaaggc ccaactgact gtagacacat cctccagcac agcctacatg    300

caattcagca gcctgacaac tgaggactct gccatctatt actgtgcaag agagggggtc    360

gacgggtggt ttacttactg gggccaaggg actctggtca ctgtctctgc agccaaaacg    420

acacccccat ctgtctatcc actggcccct ggatctgctg cccaaactaa ctccatggtg    480

accctgggat gcctggtcaa gggctatttc cctgagccag tgacagtgac ctggaactct    540

ggatccctgt ccagcggtgt gcacaccttc ccagctgtcc tgcagtctga cctctacact    600

ctgagcagct cagtgactgt cccctccagc acctggccca gcgagaccgt cacctgcaac    660

gttgcccacc cggccagcag caccaaggtg gacaagaaaa ttgtgcccag ggattgtggt    720

tgtaagcctt gcatatgtac agtcccagaa gtatcatctg tcttcatctt ccccccaaag    780

cccaaggatg tgctcaccat tactctgact cctaaggtca cgtgtgttgt ggtagacatc    840

agcaaggatg atcccgaggt ccagttcagc tggtttgtag atgatgtgga ggtgcacaca    900

gctcagacgc aaccccggga ggagcagttc aacagcactt tccgctcagt cagtgaactt    960

cccatcatgc accaggactg gctcaatggc aaggagttca aatgcagggt caacagtgca   1020

gctttccctg cccccatcga gaaaaccatc tccaaaacca aaggcagacc gaaggctcca   1080

caggtgtaca ccattccacc tcccaaggag cagatggcca aggataaagt cagtctgacc   1140

tgcatgataa cagacttctt ccctgaagac attactgtgg agtggcagtg gaatgggcag   1200

ccagcggaga actacaagaa cactcagccc atcatggaca cagatggctc ttacttcgtc   1260

tacagcaagc tcaatgtgca gaagagcaac tgggaggcag gaaatacttt cacctgctct   1320

gtgttacatg agggcctgca caaccaccat actgagaaga gcctctccca ctctcctggt   1380

aaa                                                                 1383


<210>  28
<211>  442
<212>  PRT
<213>  Mus musculus

<400>  28

Gln Gly Gln Met Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe Asn Ser His 
            20                  25                  30          


Tyr Ile Ser Trp Leu Lys Gln Lys Pro Gly Gln Thr Leu Glu Trp Ile 
        35                  40                  45              


Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Val Asp Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr 
            180                 185                 190         


Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro 
    210                 215                 220                 


Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp 
            260                 265                 270         


Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser 
305                 310                 315                 320 


Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                325                 330                 335     


Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln 
            340                 345                 350         


Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe 
        355                 360                 365             


Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu 
    370                 375                 380                 


Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe 
385                 390                 395                 400 


Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn 
                405                 410                 415     


Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr 
            420                 425                 430         


Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440         


<210>  29
<211>  720
<212>  DNA
<213>  Homo sapiens

<400>  29
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtgaca ttgtgctgac ccaatctcca gcttctttgg ctgtgtctct agggcagagg    120

gccaccatct cctgcagagc cagcgaaagt gttgataatt atggcattag ttttatgaac    180

tggttccaac agaaaccagg acagccaccc aaactcctca tctatgatgc atccaaccaa    240

ggatacgggg tccctgccag gtttagtgcc agtgggtctg ggacagactt cagcctcaac    300

atccatccta tggaggagga tgatattgca atgtatttct gtcagcaaag taaggaggtt    360

ccgtacacgt tcggaggggg gaccaaactg gaaataaaac gtacggtggc tgcaccatct    420

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc    480

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc    540

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc    600

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc    660

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt    720


<210>  30
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Val Leu Thr Gln Ser Pro Ala Ser 
            20                  25                  30          


Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Gln 
65                  70                  75                  80  


Gly Tyr Gly Val Pro Ala Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Ser Leu Asn Ile His Pro Met Glu Glu Asp Asp Ile Ala Met Tyr 
            100                 105                 110         


Phe Cys Gln Gln Ser Lys Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  31
<211>  1389
<212>  DNA
<213>  Homo sapiens

<400>  31
atggaatgga actgggtcgt tctcttcctc ctgtcattaa ctgcaggtgt ctatgcccag     60

ggtcagatgc agcagtctgg agctgagctg gtgaagcctg gggcttcagt gaagctgtcc    120

tgcaagactt ctggcttcac cttcaacagt cactatataa gttggttgaa gcaaaagcct    180

ggacagactc ttgagtggat tgcatggatt tatgctggaa ctggtggtac taggtataat    240

cagaagttca caggcaaggc ccaactgact gtagacacat cctccagcac agcctacatg    300

caattcagca gcctgacaac tgaggactct gccatctatt actgtgcaag agagggggtc    360

gacgggtggt ttacttactg gggccaaggg actctggtca ctgtctctgc agcctccacc    420

aagggcccat cggtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcg    480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca    540

ggcgctctga ccagcggcgt gcacaccttc ccagctgtcc tacagtcctc aggactctac    600

tccctcagca gcgtggtgac cgtgccctcc agcaacttcg gcacccagac ctacacctgc    660

aacgtagatc acaagcccag caacaccaag gtggacaaga cagttgagcg caaatgttgt    720

gtcgagtgcc caccgtgccc agcaccacct gtggcaggac cgtcagtctt cctcttcccc    780

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacgtg cgtggtggtg    840

gacgtgagcc acgaagaccc cgaggtccag ttcaactggt acgtggacgg cgtggaggtg    900

cataatgcca agacaaagcc acgggaggag cagttcaaca gcacgttccg tgtggtcagc    960

gtcctcaccg ttgtgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc   1020

aacaaaggcc tcccagcccc catcgagaaa accatctcca aaaccaaagg gcagccccga   1080

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc   1140

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat   1200

gggcagccgg agaacaacta caagaccaca cctcccatgc tggactccga cggctccttc   1260

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1320

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1380

ccgggtaaa                                                           1389


<210>  32
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Glu Trp Asn Trp Val Val Leu Phe Leu Leu Ser Leu Thr Ala Gly 
1               5                   10                  15      


Val Tyr Ala Gln Gly Gln Met Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Asn Ser His Tyr Ile Ser Trp Leu Lys Gln Lys Pro Gly Gln Thr Leu 
    50                  55                  60                  


Glu Trp Ile Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Phe Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly Val Asp Gly Trp Phe Thr Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  33
<211>  1407
<212>  DNA
<213>  Homo sapiens

<400>  33
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggtt gagaggtgcc     60

agatgtcagg tgcaattggt tcagagtggg gcggaggtca agaagcctgg agccagtgtc    120

aaagtcagct gcaaggcctc cggctacaca tttactactt acggaatgtc ttgggtgcgc    180

caagccccag ggcaagggct tgaatggatg ggttggatca acacttatag cggagttcca    240

acctacgccg atgactttaa aggccggttt gtcttttccc tggacacaag cgtttcaacc    300

gcctatctgc agattaattc cctgaaggcg gaggacacag ccgtttacta ttgtgcaaga    360

ggaagagagt actactacgg cagtggcatc gcattttggg gccagggcac tctggtcacc    420

gtctctagtg cctccaccaa gggcccatcg gtcttccccc tggcgccctg ctccaggagc    480

acctccgaga gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg    540

acggtgtcgt ggaactcagg cgctctgacc agcggcgtgc acaccttccc agctgtccta    600

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag caacttcggc    660

acccagacct acacctgcaa cgtagatcac aagcccagca acaccaaggt ggacaagaca    720

gttgagcgca aatgttgtgt cgagtgccca ccgtgcccag caccacctgt ggcaggaccg    780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag    840

gtcacgtgcg tggtggtgga cgtgagccac gaagaccccg aggtccagtt caactggtac    900

gtggacggcg tggaggtgca taatgccaag acaaagccac gggaggagca gttcaacagc    960

acgttccgtg tggtcagcgt cctcaccgtt gtgcaccagg actggctgaa cggcaaggag   1020

tacaagtgca aggtctccaa caaaggcctc ccagccccca tcgagaaaac catctccaaa   1080

accaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg   1140

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc   1200

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacacc tcccatgctg   1260

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag   1320

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag   1380

aagagcctct ccctgtctcc gggtaaa                                       1407


<210>  34
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Thr Tyr Gly Met Ser Trp Val Lys Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Val Phe Ser Leu Asp Thr 
                85                  90                  95      


Ser Val Ser Thr Ala Tyr Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Phe Cys Val Arg Gly Arg Glu Tyr Tyr Tyr Gly Ser 
        115                 120                 125             


Gly Ile Ala Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
145                 150                 155                 160 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr 
225                 230                 235                 240 


Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
305                 310                 315                 320 


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  35
<211>  1398
<212>  DNA
<213>  Homo sapiens

<400>  35
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtcagg tgcagcttgt gcaatccggg gctgaggtta aaaaaccagg gtccagcgtg    120

aaagtttcct gcaaggcctc tggaggaacg tttagctcca cgtacattag ctgggtgaga    180

caagcccctg gacagggctt ggaatggatc gcctggatct acgcaggtac cgggggtacc    240

agatacaatc agaaatttac aggtaaggcc caacttactg ctgacgagag tacaagcact    300

gcctatatgg aattgtctag cctgcgctcc gaggatacag ctgtctacta ctgtgcccga    360

gagggcgtgg acgggtggtt tacctactgg ggacagggaa cccttgtgac cgtctctagt    420

gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag    480

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    540

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca    600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc    660

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc    720

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc    780

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc    840

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc    900

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt    960

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc   1020

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg   1080

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac   1140

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg   1200

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac   1260

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac   1320

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc   1380

tccctgtctc cgggtaaa                                                 1398


<210>  36
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Gly Thr Phe Ser Ser Thr Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Ile Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr 
65                  70                  75                  80  


Arg Tyr Asn Arg Lys Phe Thr Gly Lys Ala Gln Leu Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Val Asp Gly Trp Phe Thr 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  37
<211>  714
<212>  DNA
<213>  Homo sapiens

<400>  37
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat     60

gttgtgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc    120

tcttgcagat ctagtcagag ccttgaacac agtaatggaa acacctattt acattggtac    180

ctgcagaagc caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct    240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc    300

agagtggagg ctgaggatct gggagtttat ttctgctctc aaagtacaca tgttccgctc    360

acgttcggtg ctgggaccaa ggtggagctg aaacgaactg tggctgcacc atctgtcttc    420

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg    480

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg    540

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc    600

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc    660

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt          714


<210>  38
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Glu His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Ser Gln Ser Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Val 
        115                 120                 125             


Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  39
<211>  1398
<212>  DNA
<213>  Homo sapiens

<400>  39
atgggttggc tgtggaactt gctattcctg atggcagctg cccaaagtgc ccaagcacag     60

atccacttgg tacagtctgg acctgagctg aagaagcctg gagagactgt caagatctcc    120

tgcaaggcgt ctgggttttc cttcacaacc tatggaatga gctgggtgaa acaggctcca    180

ggaaagggtt taaagtggat gggctggata aatacctact ctggagtgcc tacatatgct    240

gatgacttca agggacggtt tgccttctct ttggaaacct ctgccagcac tgcctatttg    300

cagatcaaca acctcaaaaa tgaggacacg gctacatatt tctgtgtaag ggggagggaa    360

tattactacg gtagtggcat tgctttctgg ggccaaggga ctctggtcac tgtctctgca    420

gcctccacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag    480

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    540

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca    600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc    660

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagcgc    720

aaatgttgtg tcgagtgccc accgtgccca gcaccacctg tggcaggacc gtcagtcttc    780

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacgtgc    840

gtggtggtgg acgtgagcca cgaagacccc gaggtccagt tcaactggta cgtggacggc    900

gtggaggtgc ataatgccaa gacaaagcca cgggaggagc agttcaacag cacgttccgt    960

gtggtcagcg tcctcaccgt tgtgcaccag gactggctga acggcaagga gtacaagtgc   1020

aaggtctcca acaaaggcct cccagccccc atcgagaaaa ccatctccaa aaccaaaggg   1080

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac   1140

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg   1200

gagagcaatg ggcagccgga gaacaactac aagaccacac ctcccatgct ggactccgac   1260

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac   1320

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc   1380

tccctgtctc cgggtaaa                                                 1398


<210>  40
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Gly Trp Leu Trp Asn Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Ala Gln Ile His Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Ser Phe 
        35                  40                  45              


Thr Thr Tyr Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Val Arg Gly Arg Glu Tyr Tyr Tyr Gly Ser Gly Ile Ala 
        115                 120                 125             


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  41
<211>  714
<212>  DNA
<213>  Homo sapiens

<400>  41
atggagaaag acacactcct gctatgggtc ctgcttctct gggttccagg gtccacaggt     60

gacattgtgc tgacccaatc tccaccttct ttggctgtgt ctctagggca gagggccacc    120

atctcctgca gagccagcga aagtgttgat aattatggct ctagttttat gaactggttc    180

caacagaaac caggacagcc acccaaactc ctcatctttg ctgcatccaa ccaaggatcc    240

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat    300

cctatggagg aggatgatgc tgcaatgtat ttctgtcagc aaagtaagga ggttccgtac    360

acgttcggag gggggaccaa actggaaata aaacgaactg tggctgcacc atctgtcttc    420

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg    480

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg    540

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc    600

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc    660

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt          714


<210>  42
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Glu Lys Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Asn Tyr Gly Ser Ser Phe Met Asn Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Phe Ala Ala Ser Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
                85                  90                  95      


Leu Asn Ile His Pro Met Glu Glu Asp Asp Ala Ala Met Tyr Phe Cys 
            100                 105                 110         


Gln Gln Ser Lys Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  43
<211>  1389
<212>  DNA
<213>  Homo sapiens

<400>  43
atggaatgga actgggtcgt tctcttcctc ctgtcattaa ctgcaggtgt ctatgcccag     60

ggtcagatgc agcagtctgg agctgagctg gtgaagcctg gggcttcagt gcaactgtcc    120

tgcaagactt ctggcttcac cttcagcagt acctatataa gttggttgaa gcagaagcct    180

ggacagagtc ttgagtggat tgcatggatt tatgctggca ctggtggtac cagatataat    240

cggaagttca caggcaaggc ccaactgact gtagacacat cctccagcac agcctacatg    300

caattcagca gcctgacaac tgaggactct gccatctatt actgtgcaag agagggggtc    360

gacgggtggt ttacttactg gggccagggg actctggtca ctgtctctgc agcctccacc    420

aagggcccat cggtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcg    480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca    540

ggcgctctga ccagcggcgt gcacaccttc ccagctgtcc tacagtcctc aggactctac    600

tccctcagca gcgtggtgac cgtgccctcc agcaacttcg gcacccagac ctacacctgc    660

aacgtagatc acaagcccag caacaccaag gtggacaaga cagttgagcg caaatgttgt    720

gtcgagtgcc caccgtgccc agcaccacct gtggcaggac cgtcagtctt cctcttcccc    780

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacgtg cgtggtggtg    840

gacgtgagcc acgaagaccc cgaggtccag ttcaactggt acgtggacgg cgtggaggtg    900

cataatgcca agacaaagcc acgggaggag cagttcaaca gcacgttccg tgtggtcagc    960

gtcctcaccg ttgtgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc   1020

aacaaaggcc tcccagcccc catcgagaaa accatctcca aaaccaaagg gcagccccga   1080

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc   1140

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat   1200

gggcagccgg agaacaacta caagaccaca cctcccatgc tggactccga cggctccttc   1260

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1320

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1380

ccgggtaaa                                                           1389


<210>  44
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Glu Trp Asn Trp Val Val Leu Phe Leu Leu Ser Leu Thr Ala Gly 
1               5                   10                  15      


Val Tyr Ala Gln Gly Gln Met Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Gln Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Thr Tyr Ile Ser Trp Leu Lys Gln Lys Pro Gly Gln Ser Leu 
    50                  55                  60                  


Glu Trp Ile Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Arg Lys Phe Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Phe Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly Val Asp Gly Trp Phe Thr Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  45
<211>  720
<212>  DNA
<213>  Homo sapiens

<400>  45
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggtt gagaggtgcc     60

agatgtgata tcgtgatgac ccaatctccg gatagcctgg ccgtgagtct tggggagcga    120

gctacaataa gctgtagagc gtccgaatct gttgataatt acggatcctc tttcatgaac    180

tggtatcaac agaaaccagg ccaacctcca aagctgctca tctacgcagc cagcaaccag    240

gggtccgggg tgccggatcg gttcagcggt agcggatccg gcaccgattt tacgctcacg    300

atcagttccc tgcaggccga ggacgtagcc gtatactatt gccaacagag caaagaagtg    360

ccctacacat tcggtcaggg caccaagctc gagatcaaac gtacggtggc tgcaccatct    420

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc    480

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc    540

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc    600

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc    660

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt    720


<210>  46
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Val Met Thr Gln Ser Pro Asp Ser 
            20                  25                  30          


Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Glu Ser Val Asp Asn Tyr Gly Ser Ser Phe Met Asn Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln 
65                  70                  75                  80  


Gly Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Ser Lys Glu Val Pro Tyr Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  47
<211>  1407
<212>  DNA
<213>  Rattus norvegicus

<400>  47
atggacatca ggctcagctt ggttttcctt gtcctttcca taaaaggtgt ccactgtgag     60

gtgcgactgg tggagtctgg tggaggctta gtgcagcctg gaaggtctct gaaactctcc    120

tgtgcagcct ccggattccc tttcagtaat tatggcatgg cctgggtccg ccaggctcca    180

acgagggggc tggagtgggt cgcaagtatt acttatgatg gtagtattac tttttatcga    240

gattccgtga agggccgatt cactatctcc agagataatg caaaaagtac cctgtacctg    300

caaatggaca gtctgaggtc tgaggacaca gccacttatt attgtacaag ttccgatact    360

acggattatt accacggagg gttttggttt gcttactggg gccaaggcac tctggtcact    420

gtctcttcag ctgaaacaac agccccatct gtctatccac tggctcctgg aactgctctc    480

aaaagtaact ccatggtgac cctgggatgc ctggtcaagg gctatttccc tgagccagtc    540

accgtgacct ggaactctgg agccctgtcc agcggtgtgc acaccttccc agctgtcctg    600

cagtctgggc tctacactct caccagctca gtgactgtac cctccagcac ctggcccagc    660

cagaccgtca cctgcaacgt agcccacccg gccagcagca ccaaggtgga caagaaaatt    720

gtgcccagaa actgtggagg tgattgcaag ccttgtatat gtacaggctc agaagtatca    780

tctgtcttca tcttcccccc aaagcccaaa gatgtgctca ccatcactct gactcctaag    840

gtcacgtgtg ttgtggtaga cattagccag gacgatcccg aggtccattt cagctggttt    900

gtagatgacg tggaagtcca cacagctcag actcgaccac cagaggagca gttcaacagc    960

actttccgct cagtcagtga actccccatc ctgcaccagg actggctcaa tggcaggacg   1020

ttcagatgca aggtcaccag tgcagctttc ccatccccca tcgagaaaac catctccaaa   1080

cccgaaggca gaacacaagt tccgcatgta tacaccatgt cacctaccaa ggaagagatg   1140

acccagaatg aagtcagtat cacctgcatg gtaaaaggct tctatccccc agacatttat   1200

gtggagtggc agatgaacgg gcagccacag gaaaactaca agaacactcc acctacgatg   1260

gacacagatg ggagttactt cctctacagc aagctcaatg tgaagaagga aaaatggcag   1320

cagggaaaca cgttcacgtg ttctgtgctg catgaaggcc tgcacaacca ccatactgag   1380

aagagtctct cccactctcc gggtaaa                                       1407


<210>  48
<211>  469
<212>  PRT
<213>  Rattus norvegicus

<400>  48

Met Asp Ile Arg Leu Ser Leu Val Phe Leu Val Leu Ser Ile Lys Gly 
1               5                   10                  15      


Val His Cys Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe 
        35                  40                  45              


Ser Asn Tyr Gly Met Ala Trp Val Arg Gln Ala Pro Thr Arg Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ser Ile Thr Tyr Asp Gly Ser Ile Thr Phe Tyr Arg 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Thr Ser Ser Asp Thr Thr Asp Tyr Tyr His Gly Gly Phe 
        115                 120                 125             


Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Glu Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Gly Thr Ala Leu 
145                 150                 155                 160 


Lys Ser Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ala Leu Ser Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Gly Leu Tyr Thr Leu Thr 
        195                 200                 205             


Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr 
    210                 215                 220                 


Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile 
225                 230                 235                 240 


Val Pro Arg Asn Cys Gly Gly Asp Cys Lys Pro Cys Ile Cys Thr Gly 
                245                 250                 255     


Ser Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val 
            260                 265                 270         


Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile 
        275                 280                 285             


Ser Gln Asp Asp Pro Glu Val His Phe Ser Trp Phe Val Asp Asp Val 
    290                 295                 300                 


Glu Val His Thr Ala Gln Thr Arg Pro Pro Glu Glu Gln Phe Asn Ser 
305                 310                 315                 320 


Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Arg Thr Phe Arg Cys Lys Val Thr Ser Ala Ala Phe Pro Ser 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Pro Glu Gly Arg Thr Gln Val Pro 
        355                 360                 365             


His Val Tyr Thr Met Ser Pro Thr Lys Glu Glu Met Thr Gln Asn Glu 
    370                 375                 380                 


Val Ser Ile Thr Cys Met Val Lys Gly Phe Tyr Pro Pro Asp Ile Tyr 
385                 390                 395                 400 


Val Glu Trp Gln Met Asn Gly Gln Pro Gln Glu Asn Tyr Lys Asn Thr 
                405                 410                 415     


Pro Pro Thr Met Asp Thr Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Asn Val Lys Lys Glu Lys Trp Gln Gln Gly Asn Thr Phe Thr Cys Ser 
        435                 440                 445             


Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser 
    450                 455                 460                 


His Ser Pro Gly Lys 
465                 


<210>  49
<211>  711
<212>  DNA
<213>  Rattus norvegicus

<400>  49
atggagacag acagactcct gctatgggca ctgctgctct gggttccagg ctccactggt     60

gacattgtct tgacccagtc tcctgctttg gctgtgtctc tagggcagag ggccacactc    120

tcctgtaggg ccagccaaag tgtcagtata tctggacata atcttatgca ctggtaccaa    180

cagaaaccag gacagcaacc caaactcctc atctatcgtg catccaacct accatctggg    240

atccctgcca ggttcagtgg cagtgggtct gggacaggct tcaccctcac catcaatcct    300

gtgcaggctg atgacattgc aacctattac tgtcagcaga gtagggagtc tccgtggacg    360

ttcggtggag gcaccacgtt ggaattgaaa cgggctgatg ctgcaccaac tgtatctatc    420

ttcccaccat ccacggaaca gttagcaact ggaggtgcct cagtcgtgtg cctcatgaac    480

aacttctatc ccagagacat cagtgtcaag tggaagattg atggcactga acgacgagat    540

ggtgtcctgg acagtgttac tgatcaggac agcaaagaca gcacgtacag catgagcagc    600

accctctcgt tgaccaaggc tgactatgaa agtcataacc tctatacctg tgaggttgtt    660

cataagacat catcctcacc cgtcgtcaag agcttcaaca ggaatgagtg t             711


<210>  50
<211>  237
<212>  PRT
<213>  Rattus norvegicus

<400>  50

Met Glu Thr Asp Arg Leu Leu Leu Trp Ala Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              


Ser Ile Ser Gly His Asn Leu Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Gln Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Pro Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu 
                85                  90                  95      


Thr Ile Asn Pro Val Gln Ala Asp Asp Ile Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Ser Arg Glu Ser Pro Trp Thr Phe Gly Gly Gly Thr Thr Leu Glu 
        115                 120                 125             


Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser 
    130                 135                 140                 


Thr Glu Gln Leu Ala Thr Gly Gly Ala Ser Val Val Cys Leu Met Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Asp Ile Ser Val Lys Trp Lys Ile Asp Gly Thr 
                165                 170                 175     


Glu Arg Arg Asp Gly Val Leu Asp Ser Val Thr Asp Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Ser Leu Thr Lys Ala Asp 
        195                 200                 205             


Tyr Glu Ser His Asn Leu Tyr Thr Cys Glu Val Val His Lys Thr Ser 
    210                 215                 220                 


Ser Ser Pro Val Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235         


<210>  51
<211>  1416
<212>  DNA
<213>  Homo sapiens

<400>  51
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcc     60

agatgtcagg tccaactggt tgagtcaggc ggaggtgtcg tacagcctgg aagaagtttg    120

cgcctgtctt gtgcggcgtc cggattccca ttcagcaact acggcatggc ctgggttcgg    180

caagcgcccg gaaagggact ggaatgggtt gcctccatta catacgacgg gagcatcacc    240

ttttaccggg atagtgttaa gggccggttt accatctccc gcgacaactc taagaacacc    300

ctctatctcc aaatgaattc cctccgggcc gaggacaccg cagtgtatta ctgcaccagc    360

tctgacacaa ccgattatta ccacggcgga ttctggttcg cttattgggg ccaaggcaca    420

ttggtcaccg tctctagtgc ctccaccaag ggcccatcgg tcttccccct ggcgccctgc    480

tccaggagca cctccgagag cacagcggcc ctgggctgcc tggtcaagga ctacttcccc    540

gaaccggtga cggtgtcgtg gaactcaggc gctctgacca gcggcgtgca caccttccca    600

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc    660

aacttcggca cccagaccta cacctgcaac gtagatcaca agcccagcaa caccaaggtg    720

gacaagacag ttgagcgcaa atgttgtgtc gagtgcccac cgtgcccagc accacctgtg    780

gcaggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg    840

acccctgagg tcacgtgcgt ggtggtggac gtgagccacg aagaccccga ggtccagttc    900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccacg ggaggagcag    960

ttcaacagca cgttccgtgt ggtcagcgtc ctcaccgttg tgcaccagga ctggctgaac   1020

ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc cagcccccat cgagaaaacc   1080

atctccaaaa ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg   1140

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc   1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacacct   1260

cccatgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc   1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac   1380

tacacgcaga agagcctctc cctgtctccg ggtaaa                             1416


<210>  52
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Pro Phe Ser Asn Tyr Gly Met Ala Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Ser Ile Thr Tyr Asp Gly Ser Ile Thr 
65                  70                  75                  80  


Phe Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Thr Ser Ser Asp Thr Thr Asp Tyr Tyr His 
        115                 120                 125             


Gly Gly Phe Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
145                 150                 155                 160 


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  53
<211>  720
<212>  DNA
<213>  Homo sapiens

<400>  53
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcc     60

agatgtgaaa ttgtgatgac acagagccct gctaccttga gtgtttctcc gggcgagcgg    120

gccacactgt catgtagggc atcacaaagc gtgtcaatca gtgggcacaa tctcatgcat    180

tggtatcaac agaagcccgg ccaggcaccc cgccttctca tctatcgagc atccaatctg    240

ccttctggta ttccagctag attttccggc agcggctccg gcacagagtt cactctgacc    300

atcagctcct tgcaatctga ggactttgca gtgtactatt gccagcagag cagggaatca    360

ccctggacct tcgggggtgg aaccaaggtg gaaataaaac gtacggtggc tgcaccatct    420

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc    480

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc    540

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc    600

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc    660

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt    720


<210>  54
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Ile Val Met Thr Gln Ser Pro Ala Thr 
            20                  25                  30          


Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Val Ser Ile Ser Gly His Asn Leu Met His Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Ala Ser Asn Leu 
65                  70                  75                  80  


Pro Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Ser Arg Glu Ser Pro Trp Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  55
<211>  711
<212>  DNA
<213>  Homo sapiens

<400>  55
atggagacag acagactcct gctatgggca ctgctgctct gggttccagg ctccactggt     60

gacattgtct tgacccagtc tcctgctttg gctgtgtctc tagggcagag ggccacactc    120

tcctgtaggg ccagccaaag tgtcagtata tctggacata atcttatgca ctggtaccaa    180

cagaaaccag gacagcaacc caaactcctc atctatcgtg catccaacct accatctggg    240

atccctgcca ggttcagtgg cagtgggtct gggacaggct tcaccctcac catcaatcct    300

gtgcaggctg atgacattgc aacctattac tgtcagcaga gtagggagtc tccgtggacg    360

ttcggtggag gcaccacgtt ggaattgaaa cgaactgtgg ctgcaccatc tgtcttcatc    420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             711


<210>  56
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Glu Thr Asp Arg Leu Leu Leu Trp Ala Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              


Ser Ile Ser Gly His Asn Leu Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Gln Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Pro Ser Gly 
65                  70                  75                  80  


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu 
                85                  90                  95      


Thr Ile Asn Pro Val Gln Ala Asp Asp Ile Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Ser Arg Glu Ser Pro Trp Thr Phe Gly Gly Gly Thr Thr Leu Glu 
        115                 120                 125             


Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  57
<211>  1407
<212>  DNA
<213>  Homo sapiens

<400>  57
atggacatca ggctcagctt ggttttcctt gtcctttcca taaaaggtgt ccactgtgag     60

gtgcgactgg tggagtctgg tggaggctta gtgcagcctg gaaggtctct gaaactctcc    120

tgtgcagcct ccggattccc tttcagtaat tatggcatgg cctgggtccg ccaggctcca    180

acgagggggc tggagtgggt cgcaagtatt acttatgatg gtagtattac tttttatcga    240

gattccgtga agggccgatt cactatctcc agagataatg caaaaagtac cctgtacctg    300

caaatggaca gtctgaggtc tgaggacaca gccacttatt attgtacaag ttccgatact    360

acggattatt accacggagg gttttggttt gcttactggg gccaaggcac tctggtcact    420

gtctcttcag cctccaccaa gggcccatcg gtcttccccc tggcgccctg ctccaggagc    480

acctccgaga gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg    540

acggtgtcgt ggaactcagg cgctctgacc agcggcgtgc acaccttccc agctgtccta    600

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag caacttcggc    660

acccagacct acacctgcaa cgtagatcac aagcccagca acaccaaggt ggacaagaca    720

gttgagcgca aatgttgtgt cgagtgccca ccgtgcccag caccacctgt ggcaggaccg    780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag    840

gtcacgtgcg tggtggtgga cgtgagccac gaagaccccg aggtccagtt caactggtac    900

gtggacggcg tggaggtgca taatgccaag acaaagccac gggaggagca gttcaacagc    960

acgttccgtg tggtcagcgt cctcaccgtt gtgcaccagg actggctgaa cggcaaggag   1020

tacaagtgca aggtctccaa caaaggcctc ccagccccca tcgagaaaac catctccaaa   1080

accaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg   1140

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc   1200

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacacc tcccatgctg   1260

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag   1320

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag   1380

aagagcctct ccctgtctcc gggtaaa                                       1407


<210>  58
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Asp Ile Arg Leu Ser Leu Val Phe Leu Val Leu Ser Ile Lys Gly 
1               5                   10                  15      


Val His Cys Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe 
        35                  40                  45              


Ser Asn Tyr Gly Met Ala Trp Val Arg Gln Ala Pro Thr Arg Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ser Ile Thr Tyr Asp Gly Ser Ile Thr Phe Tyr Arg 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Thr Ser Ser Asp Thr Thr Asp Tyr Tyr His Gly Gly Phe 
        115                 120                 125             


Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
145                 150                 155                 160 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr 
225                 230                 235                 240 


Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
305                 310                 315                 320 


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  59
<211>  444
<212>  DNA
<213>  Mus musculus

<400>  59
atgacattga acatgctgtt ggggctgaag tgggttttct ttgttgtttt ttatcaaggt     60

gtgcattgtg aggtgcagct tgttgagtct ggtggaggat tggtgcagcc taaagggtca    120

ttgaaactct catgtgcagc ctctggattc agcttcaata cctacgccat gaactgggtc    180

cgccaggctc caggaaaggg tttggaatgg gttgctcgca taagaagtaa aagtaataat    240

tatgcaacat attatgccga ttcagtgaaa gacagattca ccatctccag agatgattca    300

gaaagcatgc tctatctgca aatgaacaac ttgaaaactg aggacacagc catgtgttac    360

tgtgtgagac ataggagcaa tgatttttac ttcgggagtg ctatggacta ctggggtcaa    420

ggaacctcag tcaccgtctc ctca                                           444


<210>  60
<211>  484
<212>  PRT
<213>  Mus musculus

<400>  60

Met Thr Leu Asn Met Leu Leu Gly Leu Lys Trp Val Phe Phe Val Val 
1               5                   10                  15      


Phe Tyr Gln Gly Val His Cys Glu Val Gln Leu Val Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Gln Pro Lys Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Ser Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Ser Asn Asn 
65                  70                  75                  80  


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
                85                  90                  95      


Arg Asp Asp Ser Glu Ser Met Leu Tyr Leu Gln Met Asn Asn Leu Lys 
            100                 105                 110         


Thr Glu Asp Thr Ala Met Cys Tyr Cys Val Arg His Arg Ser Asn Asp 
        115                 120                 125             


Phe Tyr Phe Gly Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
    130                 135                 140                 


Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala 
145                 150                 155                 160 


Pro Gly Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu 
                165                 170                 175     


Val Lys Gly Tyr Phe Pro Glu Ser Val Thr Val Thr Trp Asn Ser Gly 
            180                 185                 190         


Ser Leu Ser Ser Ser Val His Thr Phe Pro Ala Leu Leu Gln Ser Gly 
        195                 200                 205             


Leu Tyr Thr Met Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro 
    210                 215                 220                 


Ser Gln Thr Val Thr Cys Ser Val Ala His Pro Ala Ser Ser Thr Thr 
225                 230                 235                 240 


Val Asp Lys Lys Leu Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 
                245                 250                 255     


Cys Pro Pro Cys Lys Glu Cys His Lys Cys Pro Ala Pro Asn Leu Glu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Ile Lys Asp Val Leu 
        275                 280                 285             


Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


Glu Asp Asp Pro Asp Val Arg Ile Ser Trp Phe Val Asn Asn Val Glu 
305                 310                 315                 320 


Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr 
                325                 330                 335     


Ile Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser 
            340                 345                 350         


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ser Pro 
        355                 360                 365             


Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Leu Val Arg Ala Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Pro Ala Glu Gln Leu Ser Arg Lys Asp Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Val Gly Phe Asn Pro Gly Asp Ile Ser Val 
                405                 410                 415     


Glu Trp Thr Ser Asn Gly His Thr Glu Glu Asn Tyr Lys Asp Thr Ala 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn 
        435                 440                 445             


Met Lys Thr Ser Lys Trp Glu Lys Thr Asp Ser Phe Ser Cys Asn Val 
    450                 455                 460                 


Arg His Glu Gly Leu Lys Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg 
465                 470                 475                 480 


Ser Pro Gly Lys 
                


<210>  61
<211>  702
<212>  DNA
<213>  Mus musculus

<400>  61
atgagtgtgc ccactcaggt cctggggttg ctgctgctgt ggcttacaga tgccagatgt     60

gacatccaga tgactcagtc tccagcctcc ctatctgtat ctgtgggaga aactgtcacc    120

atcacatgtc gagcaagtga gaatatttac agtaatttag catggtatca gcagaaacag    180

ggagaatctc ctcagctcct ggtctatgct gcaactaact tagcagatgg tgtgccatca    240

aggttcagtg gcagtggatc agccacacag tattccctca agatcaacag cctgcagtct    300

gaagattttg ggaattatta ctgtcaacat ttttggggta ctcctccgac gttcggtgga    360

ggcaccaagc tggaaatcaa acgggctgat gctgcaccaa ctgtatccat cttcccacca    420

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac    480

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg    540

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg    600

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca    660

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gt                       702


<210>  62
<211>  234
<212>  PRT
<213>  Mus musculus

<400>  62

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser 
            20                  25                  30          


Val Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn 
        35                  40                  45              


Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Gln Gly Glu Ser Pro 
    50                  55                  60                  


Gln Leu Leu Val Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Ala Thr Gln Tyr Ser Leu Lys Ile Asn 
                85                  90                  95      


Ser Leu Gln Ser Glu Asp Phe Gly Asn Tyr Tyr Cys Gln His Phe Trp 
            100                 105                 110         


Gly Thr Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  63
<211>  411
<212>  PRT
<213>  Mus musculus

<400>  63

Ala Thr Gly Gly Ala Ala Thr Gly Gly Ala Ala Cys Thr Gly Gly Gly 
1               5                   10                  15      


Thr Cys Gly Thr Thr Cys Thr Cys Thr Thr Cys Cys Thr Cys Cys Thr 
            20                  25                  30          


Gly Thr Cys Ala Thr Thr Ala Ala Cys Thr Gly Cys Ala Gly Gly Thr 
        35                  40                  45              


Gly Thr Cys Thr Ala Thr Gly Cys Cys Cys Ala Gly Gly Gly Thr Cys 
    50                  55                  60                  


Ala Gly Ala Thr Gly Cys Ala Gly Cys Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Ala Gly Cys Thr Gly Ala Gly Cys Thr Gly Gly Thr Gly Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Gly Gly Cys Thr Thr Cys Ala Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Cys Thr Gly Thr Cys Cys Thr Gly Cys Ala Ala Gly Ala Cys 
        115                 120                 125             


Thr Thr Cys Thr Gly Gly Cys Thr Thr Cys Ala Cys Cys Thr Thr Cys 
    130                 135                 140                 


Ala Gly Cys Ala Gly Thr Ala Gly Cys Thr Ala Cys Ala Thr Ala Ala 
145                 150                 155                 160 


Gly Thr Thr Gly Gly Thr Thr Gly Ala Ala Gly Cys Ala Ala Ala Ala 
                165                 170                 175     


Gly Cys Cys Thr Gly Gly Ala Cys Ala Gly Ala Gly Thr Cys Thr Thr 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Ala Thr Thr Gly Cys Ala Thr Gly Gly Ala 
        195                 200                 205             


Thr Thr Thr Ala Thr Gly Cys Thr Gly Gly Ala Ala Cys Thr Gly Gly 
    210                 215                 220                 


Thr Gly Cys Thr Ala Cys Thr Ala Gly Gly Thr Ala Thr Thr Ala Thr 
225                 230                 235                 240 


Cys Ala Gly Ala Gly Gly Thr Thr Cys Ala Cys Ala Gly Gly Cys Ala 
                245                 250                 255     


Ala Gly Gly Cys Cys Cys Ala Ala Thr Thr Gly Ala Cys Thr Gly Thr 
            260                 265                 270         


Thr Gly Ala Cys Ala Cys Ala Thr Cys Cys Thr Cys Cys Ala Gly Cys 
        275                 280                 285             


Ala Cys Ala Gly Cys Cys Thr Ala Cys Ala Thr Gly Cys Ala Ala Cys 
    290                 295                 300                 


Thr Cys Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Cys Ala Ala Cys 
305                 310                 315                 320 


Thr Gly Ala Gly Gly Ala Cys Thr Cys Thr Gly Cys Cys Gly Thr Cys 
                325                 330                 335     


Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Ala Ala Gly Ala Gly 
            340                 345                 350         


Ala Gly Gly Gly Gly Gly Thr Cys Gly Ala Cys Gly Gly Ala Thr Gly 
        355                 360                 365             


Gly Thr Thr Thr Ala Cys Thr Thr Ala Cys Thr Gly Gly Gly Gly Cys 
    370                 375                 380                 


Cys Ala Ala Gly Gly Gly Ala Cys Thr Cys Thr Gly Gly Thr Cys Ala 
385                 390                 395                 400 


Cys Thr Gly Thr Cys Thr Cys Thr Gly Cys Ala 
                405                 410     


<210>  64
<211>  137
<212>  PRT
<213>  Mus musculus

<400>  64

Met Glu Trp Asn Trp Val Val Leu Phe Leu Leu Ser Leu Thr Ala Gly 
1               5                   10                  15      


Val Tyr Ala Gln Gly Gln Met Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Ser Tyr Ile Ser Trp Leu Lys Gln Lys Pro Gly Gln Ser Leu 
    50                  55                  60                  


Glu Trp Ile Ala Trp Ile Tyr Ala Gly Thr Gly Ala Thr Arg Tyr Tyr 
65                  70                  75                  80  


Gln Arg Phe Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly Val Asp Gly Trp Phe Thr Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135         


<210>  65
<211>  714
<212>  DNA
<213>  Mus musculus

<400>  65
atggagaaag acacactcct gctatgggtc ctgcttctct gggttccagg ttccacaggt     60

gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc    120

atctcctgca gagccagcga aagtgttgat aattatggca ttagttttat gaactggttc    180

caacagaaac caggacagcc acccaaactc ctcatctatg atgcatccaa ccaaggatac    240

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat    300

cctatggagg aggatgatat tgcaatgtat ttctgtcagc aaagtaagga ggttccgtac    360

acgttcggag gggggaccaa gctggaaatc aaacgggctg atgctgcacc aactgtatcc    420

atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg    480

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa    540

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc    600

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc    660

actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgt          714


<210>  66
<211>  238
<212>  PRT
<213>  Mus musculus

<400>  66

Met Glu Lys Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Gln Gly Tyr 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
                85                  90                  95      


Leu Asn Ile His Pro Met Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys 
            100                 105                 110         


Gln Gln Ser Lys Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  67
<211>  411
<212>  DNA
<213>  Mus musculus

<400>  67
atggaatgga actgggtcgt tctcttcctc ctgtcattaa ctgcaggtgt ctatgcccag     60

ggtcagatgc agcagtctgg agctgagctg gtgaagcctg gggcttcagt gaagctgtcc    120

tgcaagactt ctggcttcac cttcagcagt agctacataa gttggttgaa gcaaaagcct    180

ggacagagtc ttgagtggat tgcatggatt tatgctggaa ctggtgctac taggtattat    240

cagaggttca caggcaaggc ccaattgact gtagacacat cctccagcac agcctacatg    300

caactcagca gcctgacaac tgaggactct gccgtctatt actgtgcaag agagggggtc    360

gacgggtggt ttacttactg gggccaaggg actctggtca ctgtctctgc a             411


<210>  68
<211>  137
<212>  PRT
<213>  Mus musculus

<400>  68

Met Glu Trp Asn Trp Val Val Leu Phe Leu Leu Ser Leu Thr Ala Gly 
1               5                   10                  15      


Val Tyr Ala Gln Gly Gln Met Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Ser Tyr Ile Ser Trp Leu Lys Gln Lys Pro Gly Gln Ser Leu 
    50                  55                  60                  


Glu Trp Ile Ala Trp Ile Tyr Ala Gly Thr Gly Ala Thr Arg Tyr Tyr 
65                  70                  75                  80  


Gln Arg Phe Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly Val Asp Gly Trp Phe Thr Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135         


<210>  69
<211>  714
<212>  DNA
<213>  Mus musculus

<400>  69
atggagaaag acacactcct gctatgggtc ctgcttctct gggttccagg ttccacaggt     60

gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc    120

atctcctgca gagccagcga aagtgttgat aattctggca tttgttttat gaactggttc    180

caacagaaac caggacagcc acccaaactc ctcatctatg atgcatccaa ccaaggatac    240

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat    300

cctatggagg aggatgatat tgcaatgtat ttctgtcagc aaagtaagga ggttccgtac    360

acgttcggag gggggaccaa gctggaaatc aaacgggctg atgctgcacc aactgtatcc    420

atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg    480

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa    540

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc    600

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc    660

actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgt          714


<210>  70
<211>  238
<212>  PRT
<213>  Mus musculus

<400>  70

Met Glu Lys Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Asn Ser Gly Ile Cys Phe Met Asn Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Gln Gly Tyr 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
                85                  90                  95      


Leu Asn Ile His Pro Met Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys 
            100                 105                 110         


Gln Gln Ser Lys Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  71
<211>  411
<212>  DNA
<213>  Mus musculus

<400>  71
atggaatgga actgggtcgt tctcttcctc ctgtcattaa ctgcaggtgt ctatgcccag     60

ggtcagatgc agcagtctgg agctgagctg gtgaagcctg gggcttcagt gcaactgtcc    120

tgcaagactt ctggcttcac cttcagcagt acctatataa gttggttgaa gcaaaagcct    180

ggacagagtc ttgagtggat tgcatggatt tatgctggaa ctggtggtac cagatataat    240

cggaagttca caggcaaggc ccaactgact gtagacacat cctccagcac agcctacatg    300

caattcagca gcctgacaac tgaggactct gccatctatt actgtgcaag agagggggtc    360

gacgggtggt ttacttactg gggccagggg actctggtca ctgtctctgc a             411


<210>  72
<211>  137
<212>  PRT
<213>  Mus musculus

<400>  72

Met Glu Trp Asn Trp Val Val Leu Phe Leu Leu Ser Leu Thr Ala Gly 
1               5                   10                  15      


Val Tyr Ala Gln Gly Gln Met Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Gln Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Thr Tyr Ile Ser Trp Leu Lys Gln Lys Pro Gly Gln Ser Leu 
    50                  55                  60                  


Glu Trp Ile Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Arg Lys Phe Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Phe Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly Val Asp Gly Trp Phe Thr Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135         


<210>  73
<211>  714
<212>  DNA
<213>  Mus musculus

<400>  73
atggagaaag acacactcct gctatgggtc ctgcttctct gggttccagg ttccacaggt     60

gacattgtgc tgacccaatc tccaccttct ttggctgtgt ctctagggca gagggccacc    120

atctcctgca gagccagcga aagtgttgat aattatggca ctagttttat gaactggttc    180

caacagaaac caggacagcc acccaaactc ctcatctttg ctgcatccaa ccaaggatcc    240

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat    300

cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga ggttccgtac    360

acgttcggag gggggaccaa gctggaaata aaacgggctg atgctgcacc aactgtatcc    420

atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg    480

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa    540

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc    600

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc    660

actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgt          714


<210>  74
<211>  238
<212>  PRT
<213>  Mus musculus

<400>  74

Met Glu Lys Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Asn Tyr Gly Thr Ser Phe Met Asn Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Phe Ala Ala Ser Asn Gln Gly Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser 
                85                  90                  95      


Leu Asn Ile His Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys 
            100                 105                 110         


Gln Gln Ser Lys Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  75
<211>  658
<212>  DNA
<213>  Mus musculus

<400>  75
gcgctgtcag tctgtcgtga cgcagccgcc ctcagtgtct ggggccccag ggcagagggt     60

caccatgtcc tgcactggga gcagctccaa cctcggggca ggttatgatg taaactggta    120

ccagcagctt ccaggaaaag cccccaaagt cctcatctat ggtaacgaaa ttcggccctc    180

aggggtccct gaccgattct ctggctccaa gtctgacacc tcagccaccc tggacatcac    240

cggactccag actggggacg aggccgacta ttactgcgaa acgtgggata gcagtctgag    300

tactgtggtc ttcggcggag ggaccaagtt gaccgtccta ggtcagccca aggctgcccc    360

ctcggtcacg ctcttcccac cctcctctga ggagcttcaa gccaacaagg ccacactggt    420

gtgtctcata agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag    480

ccccgtcaag gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc    540

ggccagcagc tacctgagcc tgacgcctga gcagtggaag tcccacaaaa gctacagctg    600

ccaggtcacg catgaaggga gcaccgtgga gaagacagtg gcccctgcag aatgctct      658


<210>  76
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  76

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ser Val Val Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Gly Ala Pro Gly Gln Arg Val Thr Met Ser Cys Thr Gly Ser Ser 
        35                  40                  45              


Ser Asn Leu Gly Ala Gly Tyr Asp Val Asn Trp Tyr Gln Gln Leu Pro 
    50                  55                  60                  


Gly Lys Ala Pro Lys Val Leu Ile Tyr Gly Asn Glu Ile Arg Pro Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Asp Thr Ser Ala Thr 
                85                  90                  95      


Leu Asp Ile Thr Gly Leu Gln Thr Gly Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Glu Thr Trp Asp Ser Ser Leu Ser Thr Val Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
                165                 170                 175     


Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser 
            180                 185                 190         


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
        195                 200                 205             


Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His 
    210                 215                 220                 


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
225                 230                 235                 


<210>  77
<211>  708
<212>  DNA
<213>  Mus musculus

<400>  77
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtgaca tccagatgac ccagtctcca tcctccctgt ctgcttctgt aggagacaga    120

gtcaccatca cttgccgggc aagtcagagc attagcgagt acttaaattg gtaccagcag    180

aaacctgggc aggctcccag gctcctcatc tatggtgtat ccaccagggc cactggcatc    240

gcagccaggt tcagtggcag tgggtctggg acagacttca ctctcaccat cagcagcctg    300

cagcctgaag attctgcagt ttattactgt cagcaggatt ataacgttcc gtacactttt    360

ggccagggga ccaagctgga gatcaaacgt acggtggctg caccatctgt cttcatcttc    420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac    480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac    540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc    600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat    660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                 708


<210>  78
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  78

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Ile Ser Glu Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Leu Leu Ile Tyr Gly Val Ser Thr Arg Ala Thr Gly Ile 
65                  70                  75                  80  


Ala Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Asp Tyr Asn Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  79
<211>  708
<212>  DNA
<213>  Mus musculus

<400>  79
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtgaca tccagttgac ccagtctcca ttctccctgt ctgcatctgt tggagacaga    120

gtcaccatca cttgccgggc aagtcagagt attaatgata acttaaattg gtatctccag    180

aaaccgggga aagcccctaa actcctgatc tttgctgcat ccacttcgca aagtggtgtc    240

ccatcgcggt tcagcggcaa tggatttggg acagatttct ctctcatcat cagcggcctt    300

cagcctgagg atgttggcac ttattattgc caacagaatg acagcatgcc tttcaccttc    360

ggccagggga ctcgactgga cattaaacgt acggtggctg caccatctgt cttcatcttc    420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac    480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac    540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc    600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat    660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                 708


<210>  80
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  80

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Leu Thr Gln Ser Pro Phe Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Ile Asn Asp Asn Leu Asn Trp Tyr Leu Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Phe Ala Ala Ser Thr Ser Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Asn Gly Phe Gly Thr Asp Phe Ser Leu Ile 
                85                  90                  95      


Ile Ser Gly Leu Gln Pro Glu Asp Val Gly Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Asn Asp Ser Met Pro Phe Thr Phe Gly Gln Gly Thr Arg Leu Asp Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  81
<211>  708
<212>  DNA
<213>  Mus musculus

<400>  81
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtgaca tccagttgac ccagtctcca tcctccctgt ctgcttctgt tggagacaga    120

gtcaccatca cttgccaggc gagtcaagac attaacaatt atttaagttg gtatcaacag    180

aaaccaggaa aagcccctaa ggtcctgatt tacgatacat ccaatttgga aacaggggtc    240

ccatcaaggt tcagtggaag tggatctggg acagacttca ctttcaccat cagcagcctg    300

cagcctgaag atattgcaac atattactgt caacagtctg ataatctccc gtacaccttt    360

ggccagggga ccaagttgga gatcaaacgt acggtggctg caccatctgt cttcatcttc    420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac    480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac    540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc    600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat    660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                 708


<210>  82
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  82

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        35                  40                  45              


Gln Asp Ile Asn Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Val Leu Ile Tyr Asp Thr Ser Asn Leu Glu Thr Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Ser Asp Asn Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  83
<211>  711
<212>  DNA
<213>  Mus musculus

<400>  83
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtgaca tccagatgac ccagtctcca ggcaccctgt ctttgtctcc aggggaaaga    120

gccaccctct tctgtagggc cagtcagaga gttagcagca gctacttagc ctggtaccag    180

cagagacctg gccaggctcc caggctcctc atgtatggta catctagttg ggccactggc    240

atcccagaca ggttcagtgg cagtggatct gggacagatt tcactctcac catcagcagt    300

ctgcaacctg aagattttgc aacttactat tgtcaacaaa gttccagtat cccgtacact    360

tttggccagg ggaccaagct ggagatcaaa cgtacggtgg ctgcaccatc tgtcttcatc    420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             711


<210>  84
<211>  237
<212>  PRT
<213>  Mus musculus

<400>  84

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Gly Thr 
            20                  25                  30          


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser 
        35                  40                  45              


Gln Arg Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Met Tyr Gly Thr Ser Ser Trp Ala Thr Gly 
65                  70                  75                  80  


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Ser Ser Ser Ile Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  85
<211>  711
<212>  DNA
<213>  Mus musculus

<400>  85
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtgaaa cgacactcac gcagtctcca gctctcttgt ctttgtctcc aggggagaga    120

gccaccctct cctgcagggc cagccagact cttagcttcg acttcttcgc ctggtatcaa    180

cagaagcctg gccaggctcc cagtctcctc atctctggta tttccacccg ggccgctggc    240

gtcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac tatcgacaga    300

ctggaacctg aagattttgc agtgtatttc tgtcagcagt ccagcagttt accgctcacc    360

ttcggcggag ggaccaaggt ggagatcaga cgtacggtgg ctgcaccatc tgtcttcatc    420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             711


<210>  86
<211>  237
<212>  PRT
<213>  Mus musculus

<400>  86

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Glu Thr Thr Leu Thr Gln Ser Pro Ala Leu 
            20                  25                  30          


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Thr Leu Ser Phe Asp Phe Phe Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Ser Leu Leu Ile Ser Gly Ile Ser Thr Arg Ala Ala Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Asp Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
            100                 105                 110         


Gln Ser Ser Ser Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Arg Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  87
<211>  708
<212>  DNA
<213>  Mus musculus

<400>  87
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggggacaga    120

gtcaccatca cttgccgggc aagtcagagc attagcgact atttaaattg gtatcagcag    180

agaccaggga aagcccctaa cctcctgatc tttgcttcaa acactttgca aggtggggtc    240

ccatcaaggt tcagaggcag tggatctggg acagatttca ctctcaccat taacagtctg    300

caacatgaag attttggaac ttactactgt caacagagtt acagaacccc tctcactttc    360

ggcggaggga ccaaggtgga gatcaagcgt acggtggctg caccatctgt cttcatcttc    420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac    480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac    540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc    600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat    660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                 708


<210>  88
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  88

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Ile Ser Asp Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys 
    50                  55                  60                  


Ala Pro Asn Leu Leu Ile Phe Ala Ser Asn Thr Leu Gln Gly Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Asn Ser Leu Gln His Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Ser Tyr Arg Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  89
<211>  708
<212>  DNA
<213>  Mus musculus

<400>  89
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtgaca tccagatgac ccagtctcca ctctccctgt ctgcatctgt aggagacaga    120

gtcgccatca cttgtcgggc aagtcagagc attagcgact ctttaaattg gtatcagcag    180

aaaccgggaa aacctcctaa gatcgtgatc tatgctgcat ccggtttgcc gagtggggtc    240

ccatcaaggt tcagtggcgg tggctctggg acagatttca ctctcgtcat cagtactcta    300

caacctgaag attttgcaac ttactactgt caacagagtt acagtgcccc gctcactttc    360

ggcggaggga ccaaggtgga gatcagtcgt acggtggctg caccatctgt cttcatcttc    420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac    480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac    540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc    600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat    660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                 708


<210>  90
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  90

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Leu Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Ala Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Ile Ser Asp Ser Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Pro Pro Lys Ile Val Ile Tyr Ala Ala Ser Gly Leu Pro Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Val 
                85                  90                  95      


Ile Ser Thr Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Ser Tyr Ser Ala Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  91
<211>  708
<212>  DNA
<213>  Mus musculus

<400>  91
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtgaca tccagatgac ccagtctcca tcctccctgt ctgcgtctat aggagacaga    120

gtcaccatca cttgccaggc gagtcaggac attaacaact atttaaattg gtatcagcag    180

aaacaaggga aagcccctaa ggtcctgatc ttcgatgcgt ccaatttggc agcaggcgtc    240

ccatcaaggt tcagtggcag tggatctggg acagatttta ctttaaccat cagcagccta    300

cagcctgaag atattgcaac atattactgt caacaatatg acaatctccc tctgacattc    360

ggccaaggga ccaaggtgga caataaacgt acggtggctg caccatctgt cttcatcttc    420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac    480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac    540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc    600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat    660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                 708


<210>  92
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  92

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
        35                  40                  45              


Gln Asp Ile Asn Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Gln Gly Lys 
    50                  55                  60                  


Ala Pro Lys Val Leu Ile Phe Asp Ala Ser Asn Leu Ala Ala Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asp Asn Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Asp Asn 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  93
<211>  717
<212>  DNA
<213>  Mus musculus

<400>  93
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtcagt ctgtcgtgac gcagccgccc gcagtgtctg gggccccagg acagaggatc    120

accatctcct gcactgggag cagctccaac atcggggcag gttatgatgt acactggtac    180

cagcagtttc caggaacagc ccccaaagtc ctcatctttg ctaacgacta tcggccctca    240

ggggtccctg accgattctc tgcctccaag tctgccacct cagcctccct ggccatccgt    300

gggctccagt ctgaggatga ggctgattac tactgccagt cctatgacaa ccgcctgagt    360

ggttatgtct tcggaactgg gaccaaggtc accgtcctag gtcagcccaa ggctgccccc    420

tcggtcacgc tcttcccacc ctcctctgag gagcttcaag ccaacaaggc cacactggtg    480

tgtctcataa gtgacttcta cccgggagcc gtgacagtgg cctggaaggc agatagcagc    540

cccgtcaagg cgggagtgga gaccaccaca ccctccaaac aaagcaacaa caagtacgcg    600

gccagcagct acctgagcct gacgcctgag cagtggaagt cccacaaaag ctacagctgc    660

caggtcacgc atgaagggag caccgtggag aagacagtgg cccctgcaga atgctct       717


<210>  94
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  94

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ser Val Val Thr Gln Pro Pro Ala Val 
            20                  25                  30          


Ser Gly Ala Pro Gly Gln Arg Ile Thr Ile Ser Cys Thr Gly Ser Ser 
        35                  40                  45              


Ser Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Phe Pro 
    50                  55                  60                  


Gly Thr Ala Pro Lys Val Leu Ile Phe Ala Asn Asp Tyr Arg Pro Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Ala Ser Lys Ser Ala Thr Ser Ala Ser 
                85                  90                  95      


Leu Ala Ile Arg Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Asn Arg Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr 
        115                 120                 125             


Lys Val Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
                165                 170                 175     


Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser 
            180                 185                 190         


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
        195                 200                 205             


Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His 
    210                 215                 220                 


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
225                 230                 235                 


<210>  95
<211>  717
<212>  DNA
<213>  Mus musculus

<400>  95
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtcagg ctgtgctgac tcagccgtcc tcagtgtctg gggccccagg gcggagggtc    120

accatctcct gcactgggag cagttccaac atcggggcag gttatgatgt acactggtat    180

caacaacttc caggaaaagc ccccaaactc gtcatctctg ctaacaccaa tcggccctca    240

ggggtccctg accgattctc aggctccaag tctggcacct cagcctccct ggccatcact    300

gggctccagg ctgaggatga ggctgattat tactgccagt cgtatgacaa cagcgtgagt    360

gcttatgtct tcggaactgg gaccaaggtc accgtcctag gtcagcccaa ggctgccccc    420

tcggtcacgc tcttcccacc ctcctctgag gagcttcaag ccaacaaggc cacactggtg    480

tgtctcataa gtgacttcta cccgggagcc gtgacagtgg cctggaaggc agatagcagc    540

cccgtcaagg cgggagtgga gaccaccaca ccctccaaac aaagcaacaa caagtacgcg    600

gccagcagct acctgagcct gacgcctgag cagtggaagt cccacaaaag ctacagctgc    660

caggtcacgc atgaagggag caccgtggag aagacagtgg cccctgcaga atgctct       717


<210>  96
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  96

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ala Val Leu Thr Gln Pro Ser Ser Val 
            20                  25                  30          


Ser Gly Ala Pro Gly Arg Arg Val Thr Ile Ser Cys Thr Gly Ser Ser 
        35                  40                  45              


Ser Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro 
    50                  55                  60                  


Gly Lys Ala Pro Lys Leu Val Ile Ser Ala Asn Thr Asn Arg Pro Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
                85                  90                  95      


Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Asn Ser Val Ser Ala Tyr Val Phe Gly Thr Gly Thr 
        115                 120                 125             


Lys Val Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
                165                 170                 175     


Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser 
            180                 185                 190         


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
        195                 200                 205             


Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His 
    210                 215                 220                 


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
225                 230                 235                 


<210>  97
<211>  717
<212>  DNA
<213>  Mus musculus

<400>  97
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtcaga gcgctttgac tcagacaccc tcagtgtctg ggacccccgg gcagagggtc    120

accatctcct gcactgggag cagatccaac atcggggcag gatatgatgt acagtggtac    180

cagcagtttc ctggaacagc cccccgactc ctcatctatg ctaataacat tcgatcctca    240

ggggtccctg accgattctc tggctccaag tctggcacct cagcctccct ggccatcact    300

ggactccagg ctgaggatga ggctacttat tactgccagt cctatgacag aagtctcagt    360

ggttatgtct tcggaactgg gaccgaggtc accgtcgtag gtcagcccaa ggctgccccc    420

tcggtcacgc tcttcccacc ctcctctgag gagcttcaag ccaacaaggc cacactggtg    480

tgtctcataa gtgacttcta cccgggagcc gtgacagtgg cctggaaggc agatagcagc    540

cccgtcaagg cgggagtgga gaccaccaca ccctccaaac aaagcaacaa caagtacgcg    600

gccagcagct acctgagcct gacgcctgag cagtggaagt cccacaaaag ctacagctgc    660

caggtcacgc atgaagggag caccgtggag aagacagtgg cccctgcaga atgctct       717


<210>  98
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  98

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ser Ala Leu Thr Gln Thr Pro Ser Val 
            20                  25                  30          


Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Arg 
        35                  40                  45              


Ser Asn Ile Gly Ala Gly Tyr Asp Val Gln Trp Tyr Gln Gln Phe Pro 
    50                  55                  60                  


Gly Thr Ala Pro Arg Leu Leu Ile Tyr Ala Asn Asn Ile Arg Ser Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
                85                  90                  95      


Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Arg Ser Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr 
        115                 120                 125             


Glu Val Thr Val Val Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
                165                 170                 175     


Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser 
            180                 185                 190         


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
        195                 200                 205             


Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His 
    210                 215                 220                 


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
225                 230                 235                 


<210>  99
<211>  717
<212>  DNA
<213>  Mus musculus

<400>  99
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtcagt ctgtgttgac gcagccgccc tcagtgtctg gggccccagg gcagagggtc    120

accatctcct gcactgggag cagctccaac atcggggcag gttatgatgt acactggtac    180

cagcagcttc caagaacagc ccccaaactc ctcatctatg gtgacaccaa tcggccctca    240

ggggtccctg accgattctc tggctccaag tctggcacct cagcctccct ggccatcact    300

gggctccaga ctgaggatga ggctgattat tattgccagt cctatgacag cagcctgagg    360

gcttatgtct tcggaactgg gaccaaggtc accgtcctag gtcagcccaa ggctgccccc    420

tcggtcacgc tcttcccacc ctcctctgag gagcttcaag ccaacaaggc cacactggtg    480

tgtctcataa gtgacttcta cccgggagcc gtgacagtgg cctggaaggc agatagcagc    540

cccgtcaagg cgggagtgga gaccaccaca ccctccaaac aaagcaacaa caagtacgcg    600

gccagcagct acctgagcct gacgcctgag cagtggaagt cccacaaaag ctacagctgc    660

caggtcacgc atgaagggag caccgtggag aagacagtgg cccctgcaga atgctct       717


<210>  100
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  100

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ser Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser 
        35                  40                  45              


Ser Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro 
    50                  55                  60                  


Arg Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asp Thr Asn Arg Pro Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
                85                  90                  95      


Leu Ala Ile Thr Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Leu Arg Ala Tyr Val Phe Gly Thr Gly Thr 
        115                 120                 125             


Lys Val Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
                165                 170                 175     


Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser 
            180                 185                 190         


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
        195                 200                 205             


Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His 
    210                 215                 220                 


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
225                 230                 235                 


<210>  101
<211>  717
<212>  DNA
<213>  Mus musculus

<400>  101
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtcagt ctgtcgtgac gcagccgccc tcagtgtctg gggccccagg gcagagggtc    120

accatctcct gcactgggag cagctccaac atcggggcag gttatgatgt tcactggtac    180

cagcagcttc caggagcagc ccccaaagtc ctcatctttg gtaacaacaa tcggccctca    240

ggaatccctg accgagtctc tggctccaag tctggcacct cagcctccct ggccatcagt    300

ggcctccaga ctgaggatga ggctgtttat tactgccagt cctatgacag cagcctgagt    360

gcttatgtct tcggaggtgg gacccaggtc accgtccttg gtcagcccaa ggctgccccc    420

tcggtcacgc tcttcccacc ctcctctgag gagcttcaag ccaacaaggc cacactggtg    480

tgtctcataa gtgacttcta cccgggagcc gtgacagtgg cctggaaggc agatagcagc    540

cccgtcaagg cgggagtgga gaccaccaca ccctccaaac aaagcaacaa caagtacgcg    600

gccagcagct acctgagcct gacgcctgag cagtggaagt cccacaaaag ctacagctgc    660

caggtcacgc atgaagggag caccgtggag aagacagtgg cccctgcaga atgctct       717


<210>  102
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  102

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ser Val Val Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser 
        35                  40                  45              


Ser Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro 
    50                  55                  60                  


Gly Ala Ala Pro Lys Val Leu Ile Phe Gly Asn Asn Asn Arg Pro Ser 
65                  70                  75                  80  


Gly Ile Pro Asp Arg Val Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
                85                  90                  95      


Leu Ala Ile Ser Gly Leu Gln Thr Glu Asp Glu Ala Val Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Leu Ser Ala Tyr Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Gln Val Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
                165                 170                 175     


Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser 
            180                 185                 190         


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
        195                 200                 205             


Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His 
    210                 215                 220                 


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
225                 230                 235                 


<210>  103
<211>  720
<212>  DNA
<213>  Mus musculus

<400>  103
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtaatt ttatgctgac tcagccccac tctgtgtcgg agtctccggg gaagacggtt    120

accatctcct gcacccgcaa cagtggcagc attgccagca actatgtgca gtggtaccag    180

cagcgcccgg gcagttcccc cgccactgtg atctatgagg ataatcaaag accctctggg    240

gtccctgatc ggttctctgg ctccatcgac atctcctcca actctgcctc cctcaccatc    300

tctggcctga agactgagga cgaggctgac tactactgtc agtcttatga tagcagcaat    360

cccttttatg tcttcggaac tgggaccaag gtcaccgtcc tcggtcagcc caaggctgcc    420

ccctcggtca cgctcttccc accctcctct gaggagcttc aagccaacaa ggccacactg    480

gtgtgtctca taagtgactt ctacccggga gccgtgacag tggcctggaa ggcagatagc    540

agccccgtca aggcgggagt ggagaccacc acaccctcca aacaaagcaa caacaagtac    600

gcggccagca gctacctgag cctgacgcct gagcagtgga agtcccacaa aagctacagc    660

tgccaggtca cgcatgaagg gagcaccgtg gagaagacag tggcccctgc agaatgctct    720


<210>  104
<211>  240
<212>  PRT
<213>  Mus musculus

<400>  104

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asn Phe Met Leu Thr Gln Pro His Ser Val 
            20                  25                  30          


Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Arg Asn Ser 
        35                  40                  45              


Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly 
    50                  55                  60                  


Ser Ser Pro Ala Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ile Ser Ser Asn Ser Ala 
                85                  90                  95      


Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr 
            100                 105                 110         


Cys Gln Ser Tyr Asp Ser Ser Asn Pro Phe Tyr Val Phe Gly Thr Gly 
        115                 120                 125             


Thr Lys Val Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr 
    130                 135                 140                 


Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp 
                165                 170                 175     


Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro 
            180                 185                 190         


Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu 
        195                 200                 205             


Thr Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr 
    210                 215                 220                 


His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
225                 230                 235                 240 


<210>  105
<211>  717
<212>  DNA
<213>  Mus musculus

<400>  105
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtaatt ttatgctgac tcagccccac tctgtgtcgg agtctccggg gaagacgatt    120

accatctcct gcacccgcag cagtggcagc atttccagca actatgtgca gtggtaccaa    180

cagcgcccgg gcagctcccc caggatcgta atgtctgagg atgaccaaag accctctggg    240

gtctctgatc gattctctgg ctccatcgac atatcctcca actctgcctt cctcaccatc    300

tctggactga agcctgagga cgagggtgat tactactgtc agtcttatga taccgacatc    360

ccttatgtct tcggaactgg gaccaaggtc accgtcctag gtcagcccaa ggctgccccc    420

tcggtcacgc tcttcccacc ctcctctgag gagcttcaag ccaacaaggc cacactggtg    480

tgtctcataa gtgacttcta cccgggagcc gtgacagtgg cctggaaggc agatagcagc    540

cccgtcaagg cgggagtgga gaccaccaca ccctccaaac aaagcaacaa caagtacgcg    600

gccagcagct acctgagcct gacgcctgag cagtggaagt cccacaaaag ctacagctgc    660

caggtcacgc atgaagggag caccgtggag aagacagtgg cccctgcaga atgctct       717


<210>  106
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  106

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asn Phe Met Leu Thr Gln Pro His Ser Val 
            20                  25                  30          


Ser Glu Ser Pro Gly Lys Thr Ile Thr Ile Ser Cys Thr Arg Ser Ser 
        35                  40                  45              


Gly Ser Ile Ser Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly 
    50                  55                  60                  


Ser Ser Pro Arg Ile Val Met Ser Glu Asp Asp Gln Arg Pro Ser Gly 
65                  70                  75                  80  


Val Ser Asp Arg Phe Ser Gly Ser Ile Asp Ile Ser Ser Asn Ser Ala 
                85                  90                  95      


Phe Leu Thr Ile Ser Gly Leu Lys Pro Glu Asp Glu Gly Asp Tyr Tyr 
            100                 105                 110         


Cys Gln Ser Tyr Asp Thr Asp Ile Pro Tyr Val Phe Gly Thr Gly Thr 
        115                 120                 125             


Lys Val Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
                165                 170                 175     


Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser 
            180                 185                 190         


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
        195                 200                 205             


Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His 
    210                 215                 220                 


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
225                 230                 235                 


<210>  107
<211>  708
<212>  DNA
<213>  Mus musculus

<400>  107
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtgaca tccagatgac ccagtctcca tcttccctgt ctgcatctgt aggagacaga    120

atcaccataa gttgccaggc gagtcaagac attgacaact atttaaattg gtatcagcag    180

aaatcaggga aagcccctaa actcctgatc tacgatgcat acaatttgaa ggcaggggtc    240

ccctcaagat tccgtggaag tagatctggg acagattttt ttttgactat cagcagcctg    300

cagcctgaag attttgcaac ctattactgt ctacagcaat atagatatcc cctcactttc    360

ggcggaggga ctaaggtgga gatcaaacgt acggtggctg caccatctgt cttcatcttc    420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac    480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac    540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc    600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat    660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                 708


<210>  108
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  108

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Ile Thr Ile Ser Cys Gln Ala Ser 
        35                  40                  45              


Gln Asp Ile Asp Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Ser Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Tyr Asn Leu Lys Ala Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Arg Gly Ser Arg Ser Gly Thr Asp Phe Phe Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Gln Tyr Arg Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  109
<211>  717
<212>  DNA
<213>  Mus musculus

<400>  109
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtcagt ctgtgttgac gcagccgccc tcagtgtctg gggccccagg gcagagggtc    120

accatctcct gcactggggg cagctccaac atcggggcag gttatgaagt ccactggtac    180

cagttggtcc caggaagagc ccccagattc ctcattcatg gtgacaacga tcggccctca    240

ggggtccctg accgattctc ggcctccgag tctggctcct catccttcct ggccatcagt    300

gggctccagg atgatgatga ggctgattat tactgccagt cctatgacac cagcctgagt    360

gcttgggtgt tcggcggcgg gaccaagctg accgtcctag gtcagcccaa ggctgccccc    420

tcggtcacgc tcttcccacc ctcctctgag gagcttcaag ccaacaaggc cacactggtg    480

tgtctcataa gtgacttcta cccgggagcc gtgacagtgg cctggaaggc agatagcagc    540

cccgtcaagg cgggagtgga gaccaccaca ccctccaaac aaagcaacaa caagtacgcg    600

gccagcagct acctgagcct gacgcctgag cagtggaagt cccacaaaag ctacagctgc    660

caggtcacgc atgaagggag caccgtggag aagacagtgg cccctgcaga atgctct       717


<210>  110
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  110

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Ser Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Gly Ser 
        35                  40                  45              


Ser Asn Ile Gly Ala Gly Tyr Glu Val His Trp Tyr Gln Leu Val Pro 
    50                  55                  60                  


Gly Arg Ala Pro Arg Phe Leu Ile His Gly Asp Asn Asp Arg Pro Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Ala Ser Glu Ser Gly Ser Ser Ser Phe 
                85                  90                  95      


Leu Ala Ile Ser Gly Leu Gln Asp Asp Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Thr Ser Leu Ser Ala Trp Val Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 
                165                 170                 175     


Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser 
            180                 185                 190         


Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 
        195                 200                 205             


Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His 
    210                 215                 220                 


Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
225                 230                 235                 


<210>  111
<211>  711
<212>  DNA
<213>  Mus musculus

<400>  111
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtgaca tccagatgac ccagtctcca ggcaccctgt ctttgtctcc aggggaaaga    120

gccaccctct cctgcaggac cagtcagagt gttagcagta cctccgtagc ctggtaccag    180

cagaaacctg gccaggctcc caggctcctc atgtatgatg catccagtag ggccgctggc    240

atcccagaca ggttcagtgg cagtgggtct gtgacagact tcactctcac catcagcaga    300

ctggagcctg aagattttgc aacttactac tgtcaacaga gttacagtct tccgtacact    360

tttggccagg ggaccaaggt ggagatcaaa cgtacggtgg ctgcaccatc tgtcttcatc    420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             711


<210>  112
<211>  237
<212>  PRT
<213>  Mus musculus

<400>  112

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Gly Thr 
            20                  25                  30          


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser 
        35                  40                  45              


Gln Ser Val Ser Ser Thr Ser Val Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Leu Met Tyr Asp Ala Ser Ser Arg Ala Ala Gly 
65                  70                  75                  80  


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Val Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Ser Tyr Ser Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  113
<211>  711
<212>  DNA
<213>  Mus musculus

<400>  113
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtaaca tccagatgac ccagtctcca ggcaccctgt ctttgtctcc aggggaaaga    120

gccaccctct cctgcagggc cagtcagagt gttaccggca accacttagc ctggtaccag    180

cagaagcctg gccaggctcc cagggtcctc atgtatgata catccagtag ggccactggc    240

atcccagaca ggttcagtgg cagtgggtct gggacagatt tcactctcac catcagcagc    300

ctgcagcctg aagatattgc aacatattac tgtcaacagt ttgataatct cccgtacact    360

tttggccagg ggaccaagct ggagatcaaa cgtacggtgg ctgcaccatc tgtcttcatc    420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             711


<210>  114
<211>  237
<212>  PRT
<213>  Mus musculus

<400>  114

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asn Ile Gln Met Thr Gln Ser Pro Gly Thr 
            20                  25                  30          


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Ser Val Thr Gly Asn His Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Val Leu Met Tyr Asp Thr Ser Ser Arg Ala Thr Gly 
65                  70                  75                  80  


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Phe Asp Asn Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  115
<211>  708
<212>  DNA
<213>  Mus musculus

<400>  115
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtgaca tccagatgac ccagtctcca tcctccctgt cagcatctgt aggagacaga    120

gtcaccatta cttgtcgggc aagtcgagac attagtgtct atgtaaattg gtatcaactg    180

aaaccagggc aggcccctag actcctcatc tatggtgcat ccaatttggg gtttggtgtc    240

ccatcccgtt tcagcggcag tggatatggg acagatttcg ctctcaccat cagcggtctg    300

cagcctgaag attttgcaac ttactcctgt caacagagtt atagtatccc tctgacgttc    360

ggccaaggga ccagggtaga caccaaacgt acggtggctg caccatctgt cttcatcttc    420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac    480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac    540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc    600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat    660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                 708


<210>  116
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  116

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Arg Asp Ile Ser Val Tyr Val Asn Trp Tyr Gln Leu Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Leu Gly Phe Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Tyr Gly Thr Asp Phe Ala Leu Thr 
                85                  90                  95      


Ile Ser Gly Leu Gln Pro Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln 
            100                 105                 110         


Ser Tyr Ser Ile Pro Leu Thr Phe Gly Gln Gly Thr Arg Val Asp Thr 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  117
<211>  708
<212>  DNA
<213>  Mus musculus

<400>  117
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtgaca tccagatgac ccagtctcca gactccctgt ctgcatctgt aggagacaga    120

atcaccataa gttgccaggc gagtcaagac attgacaact atttaaattg gtatcagcag    180

agatcaggga aagcccctaa actcctgatc tacgatgcat acaatttgaa ggcaggggtc    240

ccctcaagat tccgtggaag tagatctggg acagattttt ttttgaccat cagcagcctg    300

cagcctgaag attttggaac ttattactgt ctacagcaga gtagttaccc cctcacgttc    360

ggccaaggga ccaaggtgga aatcaaacgt acggtggctg caccatctgt cttcatcttc    420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac    480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac    540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc    600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat    660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                 708


<210>  118
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  118

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Asp Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Ile Thr Ile Ser Cys Gln Ala Ser 
        35                  40                  45              


Gln Asp Ile Asp Asn Tyr Leu Asn Trp Tyr Gln Gln Arg Ser Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Tyr Asn Leu Lys Ala Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Arg Gly Ser Arg Ser Gly Thr Asp Phe Phe Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Gly Thr Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Gln Ser Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  119
<211>  708
<212>  DNA
<213>  Mus musculus

<400>  119
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtgaca tccagatgac ccagtctcca gctaccctgt ctctgtctcc aggggaaaga    120

gccaccctct cctgcagggc cagtcggagt gttagcagca acttagcctg gtaccagcag    180

aaacctggcc gggcccccag gctcctcatg tttggtgcat ccaccagggc cactggtgtc    240

ccagcccggt tcagtggcag tgggtctggg acagagttca ctctcaccat cagcagcctg    300

cagtctgagg atgttgcaac ttattactgt cagcacgaca atgagttgcc gctcactttc    360

ggcggaggga caaaggtgga gctcaaacgt acggtggctg caccatctgt cttcatcttc    420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac    480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac    540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc    600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat    660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt                 708


<210>  120
<211>  236
<212>  PRT
<213>  Mus musculus

<400>  120

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Thr 
            20                  25                  30          


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
        35                  40                  45              


Arg Ser Val Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg 
    50                  55                  60                  


Ala Pro Arg Leu Leu Met Phe Gly Ala Ser Thr Arg Ala Thr Gly Val 
65                  70                  75                  80  


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Ser Glu Asp Val Ala Thr Tyr Tyr Cys Gln His 
            100                 105                 110         


Asp Asn Glu Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Leu 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  121
<211>  720
<212>  DNA
<213>  Homo sapiens

<400>  121
atggacatga gggtgcccgc tcagctcctg gggctcctgc tgctgtggct gagaggtgcg     60

cgctgtgaca ttcagatgac tcagtccccc tcctctctct ccgcttcagt cggggacaga    120

gtgactatca gctgccgagc cagtgagtca gtcgataatt atggctcatc cttcatgaat    180

tggtttcagc agaagccggg aaaagcccca aagctcctca tttacgccgc ttcaaaccag    240

ggttcagggg ttccctcccg cttctccggc tctgggtctg gcactgattt tacactgact    300

attagctccc tccagcctga agactttgct acctattttt gccagcagag caaagaggtc    360

ccctatacct tcggacaggg tactaaactg gagattaaac gtacggtggc tgcaccatct    420

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc    480

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc    540

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc    600

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc    660

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt    720


<210>  122
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Glu Ser Val Asp Asn Tyr Gly Ser Ser Phe Met Asn Trp Phe Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln 
65                  70                  75                  80  


Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Phe Cys Gln Gln Ser Lys Glu Val Pro Tyr Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  123
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  123

Arg Ser Ser Gln Ser Leu Glu His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  124
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  124

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  125
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  125

Ser Gln Ser Thr His Val Pro Leu Thr 
1               5                   


<210>  126
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  126

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Val Glu Leu Lys 
            100                 105                 110         


<210>  127
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  127

Thr Tyr Gly Met Ser 
1               5   


<210>  128
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  128

Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  129
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  129

Gly Arg Glu Tyr Tyr Tyr Gly Ser Gly Ile Ala Phe 
1               5                   10          


<210>  130
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  130

Gln Ile His Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Ser Phe Thr Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Gly Arg Glu Tyr Tyr Tyr Gly Ser Gly Ile Ala Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  131
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  131

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ser Ser Phe Met Asn 
1               5                   10                  15  


<210>  132
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  132

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  133
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  133

Gln Gln Ser Lys Glu Val Pro Tyr Thr 
1               5                   


<210>  134
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  134

Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ser Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Ala Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  135
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  135

Ser Thr Tyr Ile Ser 
1               5   


<210>  136
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  136

Trp Ile Tyr Ala Gly Thr Gly Gly Thr Arg Tyr Asn Arg Lys Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  137
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  137

Glu Gly Val Asp Gly Trp Phe Thr Tyr 
1               5                   


<210>  138
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  138

Gln Gly Gln Met Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Gln Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Thr 
            20                  25                  30          


Tyr Ile Ser Trp Leu Lys Gln Lys Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Arg Tyr Asn Arg Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Val Asp Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  139
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  139

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210>  140
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  140

Asp Ala Ser Asn Gln Gly Tyr 
1               5           


<210>  141
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  141

Gln Gln Ser Lys Glu Val Pro Tyr Thr 
1               5                   


<210>  142
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  142

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Gln Gly Tyr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  143
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  143

Ser His Tyr Ile Ser 
1               5   


<210>  144
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  144

Trp Ile Tyr Ala Gly Thr Gly Gly Thr Arg Tyr Asn Gln Lys Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  145
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  145

Glu Gly Val Asp Gly Trp Phe Thr Tyr 
1               5                   


<210>  146
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  146

Gln Gly Gln Met Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe Asn Ser His 
            20                  25                  30          


Tyr Ile Ser Trp Leu Lys Gln Lys Pro Gly Gln Thr Leu Glu Trp Ile 
        35                  40                  45              


Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Val Asp Gly Trp Phe Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  147
<211>  15
<212>  PRT
<213>  Rattus norvegicus

<400>  147

Arg Ala Ser Gln Ser Val Ser Ile Ser Gly His Asn Leu Met His 
1               5                   10                  15  


<210>  148
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  148

Arg Ala Ser Asn Leu Pro Ser 
1               5           


<210>  149
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  149

Gln Gln Ser Arg Glu Ser Pro Trp Thr 
1               5                   


<210>  150
<211>  110
<212>  PRT
<213>  Rattus norvegicus

<400>  150

Asp Ile Val Leu Thr Gln Ser Pro Ala Leu Ala Val Ser Leu Gly Gln 
1               5                   10                  15      


Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ile Ser Gly 
            20                  25                  30          


His Asn Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Gln Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Arg Ala Ser Asn Leu Pro Ser Gly Ile Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Asn Pro 
65                  70                  75                  80  


Val Gln Ala Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu 
                85                  90                  95      


Ser Pro Trp Thr Phe Gly Gly Gly Thr Thr Leu Glu Leu Lys 
            100                 105                 110 


<210>  151
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  151

Gly Phe Pro Phe Ser Asn Tyr Gly Met Ala 
1               5                   10  


<210>  152
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  152

Ser Ile Thr Tyr Asp Gly Ser Ile Thr Phe Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  153
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  153

Ser Asp Thr Thr Asp Tyr Tyr His Gly Gly Phe Trp Phe Ala Tyr 
1               5                   10                  15  


<210>  154
<211>  124
<212>  PRT
<213>  Mus musculus

<400>  154

Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Thr Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Tyr Asp Gly Ser Ile Thr Phe Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Ser Asp Thr Thr Asp Tyr Tyr His Gly Gly Phe Trp Phe Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  155
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  155

Ser Ser Tyr Ile Ser 
1               5   


<210>  156
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  156

Trp Ile Tyr Ala Gly Thr Gly Ala Thr Arg Tyr Tyr Gln Arg Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  157
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  157

Glu Gly Val Asp Gly Trp Phe Thr Tyr 
1               5                   


<210>  158
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  158

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210>  159
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  159

Asp Ala Ser Asn Gln Gly Tyr 
1               5           


<210>  160
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  160

Gln Gln Ser Lys Glu Val Pro Tyr Thr 
1               5                   


<210>  161
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  161

Ser Ser Tyr Ile Ser 
1               5   


<210>  162
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  162

Trp Ile Tyr Ala Gly Thr Gly Ala Thr Arg Tyr Tyr Gln Arg Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  163
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  163

Glu Gly Val Asp Gly Trp Phe Thr Tyr 
1               5                   


<210>  164
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  164

Arg Ala Ser Glu Ser Val Asp Asn Ser Gly Ile Cys Phe Met Asn 
1               5                   10                  15  


<210>  165
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  165

Asp Ala Ser Asn Gln Gly Tyr 
1               5           


<210>  166
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  166

Gln Gln Ser Lys Glu Val Pro Tyr Thr 
1               5                   


<210>  167
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  167

Ser Thr Tyr Ile Ser 
1               5   


<210>  168
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  168

Trp Ile Tyr Ala Gly Thr Gly Gly Thr Arg Tyr Asn Arg Lys Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  169
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  169

Glu Gly Val Asp Gly Trp Phe Thr Tyr 
1               5                   


<210>  170
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  170

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Thr Ser Phe Met Asn 
1               5                   10                  15  


<210>  171
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  171

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  172
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  172

Gln Gln Ser Lys Glu Val Pro Tyr Thr 
1               5                   


<210>  173
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  173

Thr Gly Ser Ser Ser Asn Leu Gly Ala Gly Tyr Asp Val Asn 
1               5                   10                  


<210>  174
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  174

Gly Asn Glu Ile Arg Pro Ser 
1               5           


<210>  175
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  175

Glu Thr Trp Asp Ser Ser Leu Ser Thr Val Val 
1               5                   10      


<210>  176
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  176

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Met Ser Cys Thr Gly Ser Ser Ser Asn Leu Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Val 
        35                  40                  45              


Leu Ile Tyr Gly Asn Glu Ile Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Asp Thr Ser Ala Thr Leu Asp Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp Ser Ser 
                85                  90                  95      


Leu Ser Thr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  177
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  177

Arg Ala Ser Gln Ser Ile Ser Glu Tyr Leu Asn 
1               5                   10      


<210>  178
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  178

Gly Val Ser Thr Arg Ala Thr 
1               5           


<210>  179
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  179

Gln Gln Asp Tyr Asn Val Pro Tyr Thr 
1               5                   


<210>  180
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  180

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Glu Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Val Ser Thr Arg Ala Thr Gly Ile Ala Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ser Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Asn Val Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  181
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  181

Arg Ala Ser Gln Ser Ile Asn Asp Asn Leu Asn 
1               5                   10      


<210>  182
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  182

Ala Ala Ser Thr Ser Gln Ser 
1               5           


<210>  183
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  183

Gln Gln Asn Asp Ser Met Pro Phe Thr 
1               5                   


<210>  184
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  184

Asp Ile Gln Leu Thr Gln Ser Pro Phe Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Asp Asn 
            20                  25                  30          


Leu Asn Trp Tyr Leu Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ala Ala Ser Thr Ser Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Asn Gly Phe Gly Thr Asp Phe Ser Leu Ile Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Gly Thr Tyr Tyr Cys Gln Gln Asn Asp Ser Met Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Asp Ile Lys 
            100                 105         


<210>  185
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  185

Gln Ala Ser Gln Asp Ile Asn Asn Tyr Leu Ser 
1               5                   10      


<210>  186
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  186

Asp Thr Ser Asn Leu Glu Thr 
1               5           


<210>  187
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  187

Gln Gln Ser Asp Asn Leu Pro Tyr Thr 
1               5                   


<210>  188
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  188

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Asp Thr Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser Asp Asn Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  189
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  189

Arg Ala Ser Gln Arg Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  190
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  190

Gly Thr Ser Ser Trp Ala Thr 
1               5           


<210>  191
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  191

Gln Gln Ser Ser Ser Ile Pro Tyr Thr 
1               5                   


<210>  192
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  192

Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Phe Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Met Tyr Gly Thr Ser Ser Trp Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ser Ser Ile Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  193
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  193

Arg Ala Ser Gln Thr Leu Ser Phe Asp Phe Phe Ala 
1               5                   10          


<210>  194
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  194

Gly Ile Ser Thr Arg Ala Ala 
1               5           


<210>  195
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  195

Gln Gln Ser Ser Ser Leu Pro Leu Thr 
1               5                   


<210>  196
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  196

Glu Thr Thr Leu Thr Gln Ser Pro Ala Leu Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Leu Ser Phe Asp 
            20                  25                  30          


Phe Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu 
        35                  40                  45              


Ile Ser Gly Ile Ser Thr Arg Ala Ala Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ser Ser Ser Leu Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Arg 
            100                 105             


<210>  197
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  197

Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu Asn 
1               5                   10      


<210>  198
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  198

Ala Ser Asn Thr Leu Gln Gly 
1               5           


<210>  199
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  199

Gln Gln Ser Tyr Arg Thr Pro Leu Thr 
1               5                   


<210>  200
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  200

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Phe Ala Ser Asn Thr Leu Gln Gly Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln His 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Gln Ser Tyr Arg Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  201
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  201

Arg Ala Ser Gln Ser Ile Ser Asp Ser Leu Asn 
1               5                   10      


<210>  202
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  202

Ala Ala Ser Gly Leu Pro Ser 
1               5           


<210>  203
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  203

Gln Gln Ser Tyr Ser Ala Pro Leu Thr 
1               5                   


<210>  204
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  204

Asp Ile Gln Met Thr Gln Ser Pro Leu Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ala Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp Ser 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Ile Val Ile 
        35                  40                  45              


Tyr Ala Ala Ser Gly Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Val Ile Ser Thr Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Ser 
            100                 105         


<210>  205
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  205

Gln Ala Ser Gln Asp Ile Asn Asn Tyr Leu Asn 
1               5                   10      


<210>  206
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  206

Asp Ala Ser Asn Leu Ala Ala 
1               5           


<210>  207
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  207

Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  208
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  208

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Gln Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Asn Leu Ala Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Asn Lys 
            100                 105         


<210>  209
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  209

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  210
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  210

Ala Asn Asp Tyr Arg Pro Ser 
1               5           


<210>  211
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  211

Gln Ser Tyr Asp Asn Arg Leu Ser Gly Tyr Val 
1               5                   10      


<210>  212
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  212

Gln Ser Val Val Thr Gln Pro Pro Ala Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Val 
        35                  40                  45              


Leu Ile Phe Ala Asn Asp Tyr Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Ala Ser Lys Ser Ala Thr Ser Ala Ser Leu Ala Ile Arg Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Arg 
                85                  90                  95      


Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  213
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  213

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  214
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  214

Ala Asn Thr Asn Arg Pro Ser 
1               5           


<210>  215
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  215

Gln Ser Tyr Asp Asn Ser Val Ser Ala Tyr Val 
1               5                   10      


<210>  216
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  216

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ala Pro Gly Arg 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Val Ile Ser Ala Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser 
                85                  90                  95      


Val Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  217
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  217

Thr Gly Ser Arg Ser Asn Ile Gly Ala Gly Tyr Asp Val Gln 
1               5                   10                  


<210>  218
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  218

Ala Asn Asn Ile Arg Ser Ser 
1               5           


<210>  219
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  219

Gln Ser Tyr Asp Arg Ser Leu Ser Gly Tyr Val 
1               5                   10      


<210>  220
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  220

Gln Ser Ala Leu Thr Gln Thr Pro Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Arg Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Gln Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Ala Asn Asn Ile Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Thr Tyr Tyr Cys Gln Ser Tyr Asp Arg Ser 
                85                  90                  95      


Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Glu Val Thr Val Val 
            100                 105                 110     


<210>  221
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  221

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  222
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  222

Gly Asp Thr Asn Arg Pro Ser 
1               5           


<210>  223
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  223

Gln Ser Tyr Asp Ser Ser Leu Arg Ala Tyr Val 
1               5                   10      


<210>  224
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  224

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Arg Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asp Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Arg Ala Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  225
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  225

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  226
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  226

Gly Asn Asn Asn Arg Pro Ser 
1               5           


<210>  227
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  227

Gln Ser Tyr Asp Ser Ser Leu Ser Ala Tyr Val 
1               5                   10      


<210>  228
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  228

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Val 
        35                  40                  45              


Leu Ile Phe Gly Asn Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Val 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Val Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Ala Tyr Val Phe Gly Gly Gly Thr Gln Val Thr Val Leu 
            100                 105                 110     


<210>  229
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  229

Thr Arg Asn Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln 
1               5                   10              


<210>  230
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  230

Glu Asp Asn Gln Arg Pro Ser 
1               5           


<210>  231
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  231

Gln Ser Tyr Asp Ser Ser Asn Pro Phe Tyr Val 
1               5                   10      


<210>  232
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  232

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Asn Ser Gly Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Ala Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ile Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Ser Asn Pro Phe Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


<210>  233
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  233

Thr Arg Ser Ser Gly Ser Ile Ser Ser Asn Tyr Val Gln 
1               5                   10              


<210>  234
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  234

Glu Asp Asp Gln Arg Pro Ser 
1               5           


<210>  235
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  235

Gln Ser Tyr Asp Thr Asp Ile Pro Tyr Val 
1               5                   10  


<210>  236
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  236

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Ile Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Arg Ile Val 
        35                  40                  45              


Met Ser Glu Asp Asp Gln Arg Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ile Ser Ser Asn Ser Ala Phe Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Pro Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Thr 
                85                  90                  95      


Asp Ile Pro Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  237
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  237

Gln Ala Ser Gln Asp Ile Asp Asn Tyr Leu Asn 
1               5                   10      


<210>  238
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  238

Asp Ala Tyr Asn Leu Lys Ala 
1               5           


<210>  239
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  239

Leu Gln Gln Tyr Arg Tyr Pro Leu Thr 
1               5                   


<210>  240
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  240

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Ser Cys Gln Ala Ser Gln Asp Ile Asp Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Ser Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Tyr Asn Leu Lys Ala Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Phe Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Gln Tyr Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  241
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  241

Thr Gly Gly Ser Ser Asn Ile Gly Ala Gly Tyr Glu Val His 
1               5                   10                  


<210>  242
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  242

Gly Asp Asn Asp Arg Pro Ser 
1               5           


<210>  243
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  243

Gln Ser Tyr Asp Thr Ser Leu Ser Ala Trp Val 
1               5                   10      


<210>  244
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  244

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Gly Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Glu Val His Trp Tyr Gln Leu Val Pro Gly Arg Ala Pro Arg Phe 
        35                  40                  45              


Leu Ile His Gly Asp Asn Asp Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Ala Ser Glu Ser Gly Ser Ser Ser Phe Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Asp Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Thr Ser 
                85                  90                  95      


Leu Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  245
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  245

Arg Thr Ser Gln Ser Val Ser Ser Thr Ser Val Ala 
1               5                   10          


<210>  246
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  246

Asp Ala Ser Ser Arg Ala Ala 
1               5           


<210>  247
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  247

Gln Gln Ser Tyr Ser Leu Pro Tyr Thr 
1               5                   


<210>  248
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  248

Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Ser Val Ser Ser Thr 
            20                  25                  30          


Ser Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Met Tyr Asp Ala Ser Ser Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Val Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  249
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  249

Arg Ala Ser Gln Ser Val Thr Gly Asn His Leu Ala 
1               5                   10          


<210>  250
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  250

Asp Thr Ser Ser Arg Ala Thr 
1               5           


<210>  251
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  251

Gln Gln Phe Asp Asn Leu Pro Tyr Thr 
1               5                   


<210>  252
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  252

Asn Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Gly Asn 
            20                  25                  30          


His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Val Leu 
        35                  40                  45              


Met Tyr Asp Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Phe Asp Asn Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  253
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  253

Arg Ala Ser Arg Asp Ile Ser Val Tyr Val Asn 
1               5                   10      


<210>  254
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  254

Gly Ala Ser Asn Leu Gly Phe 
1               5           


<210>  255
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  255

Gln Gln Ser Tyr Ser Ile Pro Leu Thr 
1               5                   


<210>  256
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  256

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Asp Ile Ser Val Tyr 
            20                  25                  30          


Val Asn Trp Tyr Gln Leu Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Gly Phe Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Ala Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Ser Cys Gln Gln Ser Tyr Ser Ile Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Val Asp Thr Lys 
            100                 105         


<210>  257
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  257

Gln Ala Ser Gln Asp Ile Asp Asn Tyr Leu Asn 
1               5                   10      


<210>  258
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  258

Asp Ala Tyr Asn Leu Lys Ala 
1               5           


<210>  259
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  259

Leu Gln Gln Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  260
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  260

Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Ser Cys Gln Ala Ser Gln Asp Ile Asp Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Ser Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Tyr Asn Leu Lys Ala Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Phe Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Leu Gln Gln Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  261
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  261

Arg Ala Ser Arg Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  262
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  262

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  263
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  263

Gln His Asp Asn Glu Leu Pro Leu Thr 
1               5                   


<210>  264
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  264

Asp Ile Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Arg Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Arg Leu Leu Met 
        35                  40                  45              


Phe Gly Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His Asp Asn Glu Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Leu Lys 
            100                 105         


<210>  265
<211>  711
<212>  DNA
<213>  Rattus norvegicus

<400>  265
atggagacag acagactcct gctatgggca ctgctgctct gggttccagg ctccactggt     60

gacattgtct tgacccagtc tcctgctttg gctgtgtctc tagggcagag ggccacactc    120

tcctgtaggg ccagccaaag tgtcagtata tctggacata atcttatgca ctggtaccaa    180

cagaaaccag gacagcaacc caaactcctc atctatcgtg catccaacct accatctggg    240

atccctgcca ggttcagtgg cagtgggtct gggacaggct tcaccctcac catcaatcct    300

gtgcaggctg atgacattgc aacctattac tgtcagcaga gtagggagtc tccgtggacg    360

ttcggtggag gcaccacgtt ggaattgaaa cgaactgtgg ctgcaccatc tgtcttcatc    420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat    480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt    540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc    600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc    660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t             711


<210>  266
<211>  234
<212>  PRT
<213>  Rattus norvegicus

<400>  266

Met Thr Trp Thr Leu Leu Phe Leu Ala Phe Leu Tyr His Leu Thr Gly 
1               5                   10                  15      


Ser Cys Ala Gln Val Met Leu Thr Gln Pro Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Leu Glu Ser Thr Val Lys Leu Ser Cys Lys Leu Asn Ser Asp Asn Ile 
        35                  40                  45              


Gly Thr Tyr Tyr Ile His Trp Tyr Gln Gln His Glu Gly Arg Ser Pro 
    50                  55                  60                  


Thr Thr Met Ile Tyr Gly Asp Asp Lys Arg Pro Asp Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Phe Leu Thr 
                85                  90                  95      


Ile Asn Asn Val Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys His Ser 
            100                 105                 110         


Tyr Asp Asp His Ile Pro Ile Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ser Thr Pro Thr Leu Thr Val Phe Pro Pro Ser 
    130                 135                 140                 


Thr Glu Glu Leu Gln Gly Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Ser Asp Val Glu Val Ala Trp Lys Ala Asn Gly Ala 
                165                 170                 175     


Pro Ile Ser Gln Gly Val Asp Thr Ala Asn Pro Thr Lys Gln Gly Asn 
            180                 185                 190         


Lys Tyr Ile Ala Ser Ser Phe Leu Arg Leu Thr Ala Glu Gln Trp Arg 
        195                 200                 205             


Ser Arg Asn Ser Phe Thr Cys Gln Val Thr His Glu Gly Asn Thr Val 
    210                 215                 220                 


Glu Lys Ser Leu Ser Pro Ala Glu Cys Val 
225                 230                 


<210>  267
<211>  1380
<212>  DNA
<213>  Rattus norvegicus

<400>  267
atggctgtcc tggtgctgtt gctctgcctg gtgacatttc caagctgtgt cctgtcccag     60

gtgcagctga tggagtcagg acctggcctg gtgcagccct cagagaccct gtccctcacc    120

tgcactgtct ctgggttctc actgaccagc tataacgtgc actgggttcg acagcctcca    180

ggaaaaggtc tggagtggat gggagtattg tggagtgatg gagacacaga ttataattca    240

gctctcaaat cccgactgag catcagaagg gacacctcca agaaccaagt tttcttaaaa    300

atgaacagtc tgcaaagtga agacacaaat acttactact gtgtcagagg ggggttatta    360

cccgggggct actttgatta ctggggccaa ggagtcatgg tcacagtctc ctcagctgaa    420

acaacagccc catctgtcta tccactggct cctggaactg ctctcaaaag taactccatg    480

gtgaccctgg gatgcctggt caagggctat ttccctgagc cagtcaccgt gacctggaac    540

tctggagccc tgtccagcgg tgtgcacacc ttcccagctg tcctgcagtc tggactctac    600

actctcacca gctcagtgac tgtaccctcc agcacctggt ccagccaggc cgtcacctgc    660

aacgtagccc acccggccag cagcaccaag gtggacaaga aaattgtgcc aagggaatgc    720

aatccttgtg gatgtacagg ctcagaagta tcatctgtct tcatcttccc cccaaagacc    780

aaagatgtgc tcaccatcac tctgactcct aaggtcacgt gtgttgtggt agacattagc    840

cagaatgatc ccgaggtccg gttcagctgg tttatagatg acgtggaagt ccacacagct    900

cagactcatg ccccggagaa gcagtccaac agcactttac gctcagtcag tgaactcccc    960

atcgtgcacc gggactggct caatggcaag acgttcaaat gcaaagtcaa cagtggagca   1020

ttccctgccc ccatcgagaa aagcatctcc aaacccgaag gcacaccacg aggtccacag   1080

gtatacacca tggcgcctcc caaggaagag atgacccaga gtcaagtcag tatcacctgc   1140

atggtaaaag gcttctatcc cccagacatt tatacggagt ggaagatgaa cgggcagcca   1200

caggaaaact acaagaacac tccacctacg atggacacag atgggagtta cttcctctac   1260

agcaagctca atgtaaagaa agaaacatgg cagcagggaa acactttcac gtgttctgtg   1320

ctgcatgagg gcctgcacaa ccaccatact gagaagagtc tctcccactc tccgggtaaa   1380


<210>  268
<211>  460
<212>  PRT
<213>  Rattus norvegicus

<400>  268

Met Ala Val Leu Val Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Met Glu Ser Gly Pro Gly Leu Val Gln 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Asn Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Val Leu Trp Ser Asp Gly Asp Thr Asp Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Lys Ser Arg Leu Ser Ile Arg Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Val Phe Leu Lys Met Asn Ser Leu Gln Ser Glu Asp Thr Asn Thr Tyr 
            100                 105                 110         


Tyr Cys Val Arg Gly Gly Leu Leu Pro Gly Gly Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Val Met Val Thr Val Ser Ser Ala Glu Thr Thr Ala Pro 
    130                 135                 140                 


Ser Val Tyr Pro Leu Ala Pro Gly Thr Ala Leu Lys Ser Asn Ser Met 
145                 150                 155                 160 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Thr Trp Asn Ser Gly Ala Leu Ser Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Gly Leu Tyr Thr Leu Thr Ser Ser Val Thr Val 
        195                 200                 205             


Pro Ser Ser Thr Trp Ser Ser Gln Ala Val Thr Cys Asn Val Ala His 
    210                 215                 220                 


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Glu Cys 
225                 230                 235                 240 


Asn Pro Cys Gly Cys Thr Gly Ser Glu Val Ser Ser Val Phe Ile Phe 
                245                 250                 255     


Pro Pro Lys Thr Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Ile Ser Gln Asn Asp Pro Glu Val Arg Phe 
        275                 280                 285             


Ser Trp Phe Ile Asp Asp Val Glu Val His Thr Ala Gln Thr His Ala 
    290                 295                 300                 


Pro Glu Lys Gln Ser Asn Ser Thr Leu Arg Ser Val Ser Glu Leu Pro 
305                 310                 315                 320 


Ile Val His Arg Asp Trp Leu Asn Gly Lys Thr Phe Lys Cys Lys Val 
                325                 330                 335     


Asn Ser Gly Ala Phe Pro Ala Pro Ile Glu Lys Ser Ile Ser Lys Pro 
            340                 345                 350         


Glu Gly Thr Pro Arg Gly Pro Gln Val Tyr Thr Met Ala Pro Pro Lys 
        355                 360                 365             


Glu Glu Met Thr Gln Ser Gln Val Ser Ile Thr Cys Met Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Pro Asp Ile Tyr Thr Glu Trp Lys Met Asn Gly Gln Pro 
385                 390                 395                 400 


Gln Glu Asn Tyr Lys Asn Thr Pro Pro Thr Met Asp Thr Asp Gly Ser 
                405                 410                 415     


Tyr Phe Leu Tyr Ser Lys Leu Asn Val Lys Lys Glu Thr Trp Gln Gln 
            420                 425                 430         


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
        435                 440                 445             


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460 


<210>  269
<211>  235
<212>  PRT
<213>  Rattus norvegicus

<400>  269

Met Thr Trp Thr Leu Leu Phe Leu Ala Phe Leu Tyr His Leu Thr Gly 
1               5                   10                  15      


Ser Cys Ala Gln Val Met Leu Thr Gln Pro Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Leu Glu Ser Thr Val Lys Leu Ser Cys Lys Leu Asn Ser Asp Asn Ile 
        35                  40                  45              


Gly Thr Tyr Tyr Ile His Trp Tyr Gln Gln His Glu Gly Arg Ser Pro 
    50                  55                  60                  


Thr Thr Met Ile Tyr Gly Asp Asp Lys Arg Pro Asp Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Phe Leu Thr 
                85                  90                  95      


Ile Asn Asn Val Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys His Ser 
            100                 105                 110         


Tyr Asp Asp His Ile Pro Ile Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


<210>  270
<211>  464
<212>  PRT
<213>  Rattus norvegicus

<400>  270

Met Ala Val Leu Val Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Met Glu Ser Gly Pro Gly Leu Val Gln 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Asn Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Val Leu Trp Ser Asp Gly Asp Thr Asp Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Lys Ser Arg Leu Ser Ile Arg Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Val Phe Leu Lys Met Asn Ser Leu Gln Ser Glu Asp Thr Asn Thr Tyr 
            100                 105                 110         


Tyr Cys Val Arg Gly Gly Leu Leu Pro Gly Gly Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Val Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
225                 230                 235                 240 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210>  271
<211>  238
<212>  PRT
<213>  Rattus norvegicus

<400>  271

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Met Leu Thr Gln Pro His Ser Val 
            20                  25                  30          


Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Lys Leu Asn Ser 
        35                  40                  45              


Asp Asn Ile Gly Thr Tyr Tyr Ile His Trp Tyr Gln Gln Arg Glu Gly 
    50                  55                  60                  


Arg Ser Pro Thr Thr Val Ile Tyr Gly Asp Asp Lys Arg Pro Asp Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala 
                85                  90                  95      


Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Phe 
            100                 105                 110         


Cys His Ser Tyr Asp Asp His Ile Pro Ile Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Thr Val Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
                165                 170                 175     


Asp Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys 
            180                 185                 190         


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
        195                 200                 205             


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu 
    210                 215                 220                 


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235             


<210>  272
<211>  467
<212>  PRT
<213>  Rattus norvegicus

<400>  272

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Asn Val His Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Val Leu Trp Ser Asp Gly Asp Thr Asp 
65                  70                  75                  80  


Tyr Asn Ser Ala Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Val Arg Gly Gly Leu Leu Pro Gly Gly Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
225                 230                 235                 240 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  273
<211>  13
<212>  PRT
<213>  Rattus norvegicus

<400>  273

Lys Leu Asn Ser Asp Asn Ile Gly Thr Tyr Tyr Ile His 
1               5                   10              


<210>  274
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  274

Gly Asp Asp Lys Arg Pro Asp 
1               5           


<210>  275
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  275

His Ser Tyr Asp Asp His Ile Pro Ile 
1               5                   


<210>  276
<211>  129
<212>  PRT
<213>  Rattus norvegicus

<400>  276

Met Thr Trp Thr Leu Leu Phe Leu Ala Phe Leu Tyr His Leu Thr Gly 
1               5                   10                  15      


Ser Cys Ala Gln Val Met Leu Thr Gln Pro Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Leu Glu Ser Thr Val Lys Leu Ser Cys Lys Leu Asn Ser Asp Asn Ile 
        35                  40                  45              


Gly Thr Tyr Tyr Ile His Trp Tyr Gln Gln His Glu Gly Arg Ser Pro 
    50                  55                  60                  


Thr Thr Met Ile Tyr Gly Asp Asp Lys Arg Pro Asp Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Phe Leu Thr 
                85                  90                  95      


Ile Asn Asn Val Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys His Ser 
            100                 105                 110         


Tyr Asp Asp His Ile Pro Ile Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu 
    


<210>  277
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  277

Ser Tyr Asn Val His 
1               5   


<210>  278
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  278

Val Leu Trp Ser Asp Gly Asp Thr Asp Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  279
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  279

Gly Gly Leu Leu Pro Gly Gly Tyr Phe Asp Tyr 
1               5                   10      


<210>  280
<211>  138
<212>  PRT
<213>  Rattus norvegicus

<400>  280

Met Ala Val Leu Val Leu Leu Leu Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Met Glu Ser Gly Pro Gly Leu Val Gln 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Asn Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Val Leu Trp Ser Asp Gly Asp Thr Asp Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Lys Ser Arg Leu Ser Ile Arg Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Val Phe Leu Lys Met Asn Ser Leu Gln Ser Glu Asp Thr Asn Thr Tyr 
            100                 105                 110         


Tyr Cys Val Arg Gly Gly Leu Leu Pro Gly Gly Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Val Met Val Thr Val Ser Ser 
    130                 135             


<210>  281
<211>  49
<212>  DNA
<213>  Mus musculus

<400>  281
ccgttcgtgg cccagccggc ctctgctcag gttcagctgg tgcagtctg                 49


<210>  282
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  282
gtgatggtga tgatgatgtg cggccgcaca tttgcgctca actgtcttgt c              51


