                              Sequence Listing

<110> GENENTECH, INC.
      Hongo, Jo-Anne S.
      Li, Jing
      Smith, Victoria

<120> COMPOSITIONS AND METHODS FOR INHIBITING TUMOR PROGRESSION

<130> P2478R1


<150> US 60/988,874
<151> 2007-11-19

<160> 11

<210> 1
<211> 2556
<212> PRT
<213> Homo sapiens

<400> 1
 Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro
   1               5                  10                  15

 Ala Leu Ala Ala Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr
                  20                  25                  30

 Cys Leu Asn Gly Gly Lys Cys Glu Ala Ala Asn Gly Thr Glu Ala
                  35                  40                  45

 Cys Val Cys Gly Gly Ala Phe Val Gly Pro Arg Cys Gln Asp Pro
                  50                  55                  60

 Asn Pro Cys Leu Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His
                  65                  70                  75

 Val Val Asp Arg Arg Gly Val Ala Asp Tyr Ala Cys Ser Cys Ala
                  80                  85                  90

 Leu Gly Phe Ser Gly Pro Leu Cys Leu Thr Pro Leu Asp Asn Ala
                  95                 100                 105

 Cys Leu Thr Asn Pro Cys Arg Asn Gly Gly Thr Cys Asp Leu Leu
                 110                 115                 120

 Thr Leu Thr Glu Tyr Lys Cys Arg Cys Pro Pro Gly Trp Ser Gly
                 125                 130                 135

 Lys Ser Cys Gln Gln Ala Asp Pro Cys Ala Ser Asn Pro Cys Ala
                 140                 145                 150

 Asn Gly Gly Gln Cys Leu Pro Phe Glu Ala Ser Tyr Ile Cys His
                 155                 160                 165

 Cys Pro Pro Ser Phe His Gly Pro Thr Cys Arg Gln Asp Val Asn
                 170                 175                 180

 Glu Cys Gly Gln Lys Pro Arg Leu Cys Arg His Gly Gly Thr Cys
                 185                 190                 195

 His Asn Glu Val Gly Ser Tyr Arg Cys Val Cys Arg Ala Thr His
                 200                 205                 210

 Thr Gly Pro Asn Cys Glu Arg Pro Tyr Val Pro Cys Ser Pro Ser
                 215                 220                 225

 Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Val Thr
                 230                 235                 240

 His Glu Cys Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn Cys Glu
                 245                 250                 255

 Glu Asn Ile Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly
                 260                 265                 270

 Ala Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Pro Cys Pro Pro
                 275                 280                 285

 Glu Trp Thr Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln
                 290                 295                 300

 Leu Met Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr
                 305                 310                 315

 His Gly Gly Tyr Asn Cys Val Cys Val Asn Gly Trp Thr Gly Glu
                 320                 325                 330

 Asp Cys Ser Glu Asn Ile Asp Asp Cys Ala Ser Ala Ala Cys Phe
                 335                 340                 345

 His Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe Tyr Cys Glu
                 350                 355                 360

 Cys Pro His Gly Arg Thr Gly Leu Leu Cys His Leu Asn Asp Ala
                 365                 370                 375

 Cys Ile Ser Asn Pro Cys Asn Glu Gly Ser Asn Cys Asp Thr Asn
                 380                 385                 390

 Pro Val Asn Gly Lys Ala Ile Cys Thr Cys Pro Ser Gly Tyr Thr
                 395                 400                 405

 Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys Ser Leu Gly Ala
                 410                 415                 420

 Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr Leu Gly Ser
                 425                 430                 435

 Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg Cys Glu
                 440                 445                 450

 Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp Ala
                 455                 460                 465

 Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Met Cys Met Pro
                 470                 475                 480

 Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr Asp Glu Cys Ala
                 485                 490                 495

 Ser Ser Pro Cys Leu His Asn Gly Arg Cys Leu Asp Lys Ile Asn
                 500                 505                 510

 Glu Phe Gln Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys
                 515                 520                 525

 Gln Tyr Asp Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly
                 530                 535                 540

 Ala Lys Cys Leu Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr
                 545                 550                 555

 Glu Gly Tyr Thr Gly Thr His Cys Glu Val Asp Ile Asp Glu Cys
                 560                 565                 570

 Asp Pro Asp Pro Cys His Tyr Gly Ser Cys Lys Asp Gly Val Ala
                 575                 580                 585

 Thr Phe Thr Cys Leu Cys Arg Pro Gly Tyr Thr Gly His His Cys
                 590                 595                 600

 Glu Thr Asn Ile Asn Glu Cys Ser Ser Gln Pro Cys Arg Leu Arg
                 605                 610                 615

 Gly Thr Cys Gln Asp Pro Asp Asn Ala Tyr Leu Cys Phe Cys Leu
                 620                 625                 630

 Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile Asn Leu Asp Asp Cys
                 635                 640                 645

 Ala Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu Asp Lys Ile Asp
                 650                 655                 660

 Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly Ser Met Cys
                 665                 670                 675

 Asn Ser Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His Asn Gly
                 680                 685                 690

 Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys Pro
                 695                 700                 705

 Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys
                 710                 715                 720

 Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp Ser Leu Asn
                 725                 730                 735

 Gly Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr Asn Cys
                 740                 745                 750

 Asp Ile Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly
                 755                 760                 765

 Gly Thr Cys Lys Asp Met Thr Ser Gly Ile Val Cys Thr Cys Arg
                 770                 775                 780

 Glu Gly Phe Ser Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys
                 785                 790                 795

 Ala Ser Asn Pro Cys Leu Asn Lys Gly Thr Cys Ile Asp Asp Val
                 800                 805                 810

 Ala Gly Tyr Lys Cys Asn Cys Leu Leu Pro Tyr Thr Gly Ala Thr
                 815                 820                 825

 Cys Glu Val Val Leu Ala Pro Cys Ala Pro Ser Pro Cys Arg Asn
                 830                 835                 840

 Gly Gly Glu Cys Arg Gln Ser Glu Asp Tyr Glu Ser Phe Ser Cys
                 845                 850                 855

 Val Cys Pro Thr Ala Gly Ala Lys Gly Gln Thr Cys Glu Val Asp
                 860                 865                 870

 Ile Asn Glu Cys Val Leu Ser Pro Cys Arg His Gly Ala Ser Cys
                 875                 880                 885

 Gln Asn Thr His Gly Gly Tyr Arg Cys His Cys Gln Ala Gly Tyr
                 890                 895                 900

 Ser Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys Arg Pro Asn
                 905                 910                 915

 Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr Ala
                 920                 925                 930

 Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu Glu
                 935                 940                 945

 Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn
                 950                 955                 960

 Cys Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly
                 965                 970                 975

 Phe Ser Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu
                 980                 985                 990

 Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser
                 995                1000                1005

 Phe Thr Cys Leu Cys Pro Pro Gly Phe Thr Gly Ser Tyr Cys Gln
                1010                1015                1020

 His Val Val Asn Glu Cys Asp Ser Arg Pro Cys Leu Leu Gly Gly
                1025                1030                1035

 Thr Cys Gln Asp Gly Arg Gly Leu His Arg Cys Thr Cys Pro Gln
                1040                1045                1050

 Gly Tyr Thr Gly Pro Asn Cys Gln Asn Leu Val His Trp Cys Asp
                1055                1060                1065

 Ser Ser Pro Cys Lys Asn Gly Gly Lys Cys Trp Gln Thr His Thr
                1070                1075                1080

 Gln Tyr Arg Cys Glu Cys Pro Ser Gly Trp Thr Gly Leu Tyr Cys
                1085                1090                1095

 Asp Val Pro Ser Val Ser Cys Glu Val Ala Ala Gln Arg Gln Gly
                1100                1105                1110

 Val Asp Val Ala Arg Leu Cys Gln His Gly Gly Leu Cys Val Asp
                1115                1120                1125

 Ala Gly Asn Thr His His Cys Arg Cys Gln Ala Gly Tyr Thr Gly
                1130                1135                1140

 Ser Tyr Cys Glu Asp Leu Val Asp Glu Cys Ser Pro Ser Pro Cys
                1145                1150                1155

 Gln Asn Gly Ala Thr Cys Thr Asp Tyr Leu Gly Gly Tyr Ser Cys
                1160                1165                1170

 Lys Cys Val Ala Gly Tyr His Gly Val Asn Cys Ser Glu Glu Ile
                1175                1180                1185

 Asp Glu Cys Leu Ser His Pro Cys Gln Asn Gly Gly Thr Cys Leu
                1190                1195                1200

 Asp Leu Pro Asn Thr Tyr Lys Cys Ser Cys Pro Arg Gly Thr Gln
                1205                1210                1215

 Gly Val His Cys Glu Ile Asn Val Asp Asp Cys Asn Pro Pro Val
                1220                1225                1230

 Asp Pro Val Ser Arg Ser Pro Lys Cys Phe Asn Asn Gly Thr Cys
                1235                1240                1245

 Val Asp Gln Val Gly Gly Tyr Ser Cys Thr Cys Pro Pro Gly Phe
                1250                1255                1260

 Val Gly Glu Arg Cys Glu Gly Asp Val Asn Glu Cys Leu Ser Asn
                1265                1270                1275

 Pro Cys Asp Ala Arg Gly Thr Gln Asn Cys Val Gln Arg Val Asn
                1280                1285                1290

 Asp Phe His Cys Glu Cys Arg Ala Gly His Thr Gly Arg Arg Cys
                1295                1300                1305

 Glu Ser Val Ile Asn Gly Cys Lys Gly Lys Pro Cys Lys Asn Gly
                1310                1315                1320

 Gly Thr Cys Ala Val Ala Ser Asn Thr Ala Arg Gly Phe Ile Cys
                1325                1330                1335

 Lys Cys Pro Ala Gly Phe Glu Gly Ala Thr Cys Glu Asn Asp Ala
                1340                1345                1350

 Arg Thr Cys Gly Ser Leu Arg Cys Leu Asn Gly Gly Thr Cys Ile
                1355                1360                1365

 Ser Gly Pro Arg Ser Pro Thr Cys Leu Cys Leu Gly Pro Phe Thr
                1370                1375                1380

 Gly Pro Glu Cys Gln Phe Pro Ala Ser Ser Pro Cys Leu Gly Gly
                1385                1390                1395

 Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu Pro Thr Ser Glu Ser
                1400                1405                1410

 Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe Asn Gly Leu Leu
                1415                1420                1425

 Cys His Ile Leu Asp Tyr Ser Phe Gly Gly Gly Ala Gly Arg Asp
                1430                1435                1440

 Ile Pro Pro Pro Leu Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys
                1445                1450                1455

 Gln Glu Asp Ala Gly Asn Lys Val Cys Ser Leu Gln Cys Asn Asn
                1460                1465                1470

 His Ala Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn
                1475                1480                1485

 Asp Pro Trp Lys Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr
                1490                1495                1500

 Phe Ser Asp Gly His Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys
                1505                1510                1515

 Leu Phe Asp Gly Phe Asp Cys Gln Arg Ala Glu Gly Gln Cys Asn
                1520                1525                1530

 Pro Leu Tyr Asp Gln Tyr Cys Lys Asp His Phe Ser Asp Gly His
                1535                1540                1545

 Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys Glu Trp Asp Gly Leu
                1550                1555                1560

 Asp Cys Ala Glu His Val Pro Glu Arg Leu Ala Ala Gly Thr Leu
                1565                1570                1575

 Val Val Val Val Leu Met Pro Pro Glu Gln Leu Arg Asn Ser Ser
                1580                1585                1590

 Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu His Thr Asn Val
                1595                1600                1605

 Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile Phe Pro Tyr
                1610                1615                1620

 Tyr Gly Arg Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg Ala
                1625                1630                1635

 Ala Glu Gly Trp Ala Ala Pro Asp Ala Leu Leu Gly Gln Val Lys
                1640                1645                1650

 Ala Ser Leu Leu Pro Gly Gly Ser Glu Gly Gly Arg Arg Arg Arg
                1655                1660                1665

 Glu Leu Asp Pro Met Asp Val Arg Gly Ser Ile Val Tyr Leu Glu
                1670                1675                1680

 Ile Asp Asn Arg Gln Cys Val Gln Ala Ser Ser Gln Cys Phe Gln
                1685                1690                1695

 Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser Leu
                1700                1705                1710

 Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Gln Ser Glu
                1715                1720                1725

 Thr Val Glu Pro Pro Pro Pro Ala Gln Leu His Phe Met Tyr Val
                1730                1735                1740

 Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val
                1745                1750                1755

 Leu Leu Ser Arg Lys Arg Arg Arg Gln His Gly Gln Leu Trp Phe
                1760                1765                1770

 Pro Glu Gly Phe Lys Val Ser Glu Ala Ser Lys Lys Lys Arg Arg
                1775                1780                1785

 Glu Pro Leu Gly Glu Asp Ser Val Gly Leu Lys Pro Leu Lys Asn
                1790                1795                1800

 Ala Ser Asp Gly Ala Leu Met Asp Asp Asn Gln Asn Glu Trp Gly
                1805                1810                1815

 Asp Glu Asp Leu Glu Thr Lys Lys Phe Arg Phe Glu Glu Pro Val
                1820                1825                1830

 Val Leu Pro Asp Leu Asp Asp Gln Thr Asp His Arg Gln Trp Thr
                1835                1840                1845

 Gln Gln His Leu Asp Ala Ala Asp Leu Arg Met Ser Ala Met Ala
                1850                1855                1860

 Pro Thr Pro Pro Gln Gly Glu Val Asp Ala Asp Cys Met Asp Val
                1865                1870                1875

 Asn Val Arg Gly Pro Asp Gly Phe Thr Pro Leu Met Ile Ala Ser
                1880                1885                1890

 Cys Ser Gly Gly Gly Leu Glu Thr Gly Asn Ser Glu Glu Glu Glu
                1895                1900                1905

 Asp Ala Pro Ala Val Ile Ser Asp Phe Ile Tyr Gln Gly Ala Ser
                1910                1915                1920

 Leu His Asn Gln Thr Asp Arg Thr Gly Glu Thr Ala Leu His Leu
                1925                1930                1935

 Ala Ala Arg Tyr Ser Arg Ser Asp Ala Ala Lys Arg Leu Leu Glu
                1940                1945                1950

 Ala Ser Ala Asp Ala Asn Ile Gln Asp Asn Met Gly Arg Thr Pro
                1955                1960                1965

 Leu His Ala Ala Val Ser Ala Asp Ala Gln Gly Val Phe Gln Ile
                1970                1975                1980

 Leu Ile Arg Asn Arg Ala Thr Asp Leu Asp Ala Arg Met His Asp
                1985                1990                1995

 Gly Thr Thr Pro Leu Ile Leu Ala Ala Arg Leu Ala Val Glu Gly
                2000                2005                2010

 Met Leu Glu Asp Leu Ile Asn Ser His Ala Asp Val Asn Ala Val
                2015                2020                2025

 Asp Asp Leu Gly Lys Ser Ala Leu His Trp Ala Ala Ala Val Asn
                2030                2035                2040

 Asn Val Asp Ala Ala Val Val Leu Leu Lys Asn Gly Ala Asn Lys
                2045                2050                2055

 Asp Met Gln Asn Asn Arg Glu Glu Thr Pro Leu Phe Leu Ala Ala
                2060                2065                2070

 Arg Glu Gly Ser Tyr Glu Thr Ala Lys Val Leu Leu Asp His Phe
                2075                2080                2085

 Ala Asn Arg Asp Ile Thr Asp His Met Asp Arg Leu Pro Arg Asp
                2090                2095                2100

 Ile Ala Gln Glu Arg Met His His Asp Ile Val Arg Leu Leu Asp
                2105                2110                2115

 Glu Tyr Asn Leu Val Arg Ser Pro Gln Leu His Gly Ala Pro Leu
                2120                2125                2130

 Gly Gly Thr Pro Thr Leu Ser Pro Pro Leu Cys Ser Pro Asn Gly
                2135                2140                2145

 Tyr Leu Gly Ser Leu Lys Pro Gly Val Gln Gly Lys Lys Val Arg
                2150                2155                2160

 Lys Pro Ser Ser Lys Gly Leu Ala Cys Gly Ser Lys Glu Ala Lys
                2165                2170                2175

 Asp Leu Lys Ala Arg Arg Lys Lys Ser Gln Asp Gly Lys Gly Cys
                2180                2185                2190

 Leu Leu Asp Ser Ser Gly Met Leu Ser Pro Val Asp Ser Leu Glu
                2195                2200                2205

 Ser Pro His Gly Tyr Leu Ser Asp Val Ala Ser Pro Pro Leu Leu
                2210                2215                2220

 Pro Ser Pro Phe Gln Gln Ser Pro Ser Val Pro Leu Asn His Leu
                2225                2230                2235

 Pro Gly Met Pro Asp Thr His Leu Gly Ile Gly His Leu Asn Val
                2240                2245                2250

 Ala Ala Lys Pro Glu Met Ala Ala Leu Gly Gly Gly Gly Arg Leu
                2255                2260                2265

 Ala Phe Glu Thr Gly Pro Pro Arg Leu Ser His Leu Pro Val Ala
                2270                2275                2280

 Ser Gly Thr Ser Thr Val Leu Gly Ser Ser Ser Gly Gly Ala Leu
                2285                2290                2295

 Asn Phe Thr Val Gly Gly Ser Thr Ser Leu Asn Gly Gln Cys Glu
                2300                2305                2310

 Trp Leu Ser Arg Leu Gln Ser Gly Met Val Pro Asn Gln Tyr Asn
                2315                2320                2325

 Pro Leu Arg Gly Ser Val Ala Pro Gly Pro Leu Ser Thr Gln Ala
                2330                2335                2340

 Pro Ser Leu Gln His Gly Met Val Gly Pro Leu His Ser Ser Leu
                2345                2350                2355

 Ala Ala Ser Ala Leu Ser Gln Met Met Ser Tyr Gln Gly Leu Pro
                2360                2365                2370

 Ser Thr Arg Leu Ala Thr Gln Pro His Leu Val Gln Thr Gln Gln
                2375                2380                2385

 Val Gln Pro Gln Asn Leu Gln Met Gln Gln Gln Asn Leu Gln Pro
                2390                2395                2400

 Ala Asn Ile Gln Gln Gln Gln Ser Leu Gln Pro Pro Pro Pro Pro
                2405                2410                2415

 Pro Gln Pro His Leu Gly Val Ser Ser Ala Ala Ser Gly His Leu
                2420                2425                2430

 Gly Arg Ser Phe Leu Ser Gly Glu Pro Ser Gln Ala Asp Val Gln
                2435                2440                2445

 Pro Leu Gly Pro Ser Ser Leu Ala Val His Thr Ile Leu Pro Gln
                2450                2455                2460

 Glu Ser Pro Ala Leu Pro Thr Ser Leu Pro Ser Ser Leu Val Pro
                2465                2470                2475

 Pro Val Thr Ala Ala Gln Phe Leu Thr Pro Pro Ser Gln His Ser
                2480                2485                2490

 Tyr Ser Ser Pro Val Asp Asn Thr Pro Ser His Gln Leu Gln Val
                2495                2500                2505

 Pro Glu His Pro Phe Leu Thr Pro Ser Pro Glu Ser Pro Asp Gln
                2510                2515                2520

 Trp Ser Ser Ser Ser Pro His Ser Asn Val Ser Asp Trp Ser Glu
                2525                2530                2535

 Gly Val Ser Ser Pro Pro Thr Ser Met Gln Ser Gln Ile Ala Arg
                2540                2545                2550

 Ile Pro Glu Ala Phe Lys
                2555    

<210> 2
<211> 215
<212> PRT
<213> Homo sapiens

<400> 2
 Met His Arg Asp Ala Trp Leu Pro Arg Pro Ala Phe Ser Leu Thr
   1               5                  10                  15

 Gly Leu Ser Leu Phe Phe Ser Leu Val Pro Pro Gly Arg Ser Met
                  20                  25                  30

 Glu Val Thr Val Pro Ala Thr Leu Asn Val Leu Asn Gly Ser Asp
                  35                  40                  45

 Ala Arg Leu Pro Cys Thr Phe Asn Ser Cys Tyr Thr Val Asn His
                  50                  55                  60

 Lys Gln Phe Ser Leu Asn Trp Thr Tyr Gln Glu Cys Asn Asn Cys
                  65                  70                  75

 Ser Glu Glu Met Phe Leu Gln Phe Arg Met Lys Ile Ile Asn Leu
                  80                  85                  90

 Lys Leu Glu Arg Phe Gln Asp Arg Val Glu Phe Ser Gly Asn Pro
                  95                 100                 105

 Ser Lys Tyr Asp Val Ser Val Met Leu Arg Asn Val Gln Pro Glu
                 110                 115                 120

 Asp Glu Gly Ile Tyr Asn Cys Tyr Ile Met Asn Pro Pro Asp Arg
                 125                 130                 135

 His Arg Gly His Gly Lys Ile His Leu Gln Val Leu Met Glu Glu
                 140                 145                 150

 Pro Pro Glu Arg Asp Ser Thr Val Ala Val Ile Val Gly Ala Ser
                 155                 160                 165

 Val Gly Gly Phe Leu Ala Val Val Ile Leu Val Leu Met Val Val
                 170                 175                 180

 Lys Cys Val Arg Arg Lys Lys Glu Gln Lys Leu Ser Thr Asp Asp
                 185                 190                 195

 Leu Lys Thr Glu Glu Glu Gly Lys Thr Asp Gly Glu Gly Asn Pro
                 200                 205                 210

 Asp Asp Gly Ala Lys
                 215

<210> 3
<211> 21
<212> RNA
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 3
 caacgaaucu acccauauuu  u 21

<210> 4
<211> 21
<212> RNA
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 4
 gcgacgagcu ggacuccaau  u 21

<210> 5
<211> 21
<212> RNA
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 5
 gcgacaaggu guugacguuu  u 21

<210> 6
<211> 21
<212> RNA
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 6
 cugcagacgc agcgggucau  u 21

<210> 7
<211> 21
<212> RNA
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 7
 ggaguccgca gucuuacgau  u 21

<210> 8
<211> 21
<212> RNA
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 8
 gagcaagauu cagacccucu  u 21

<210> 9
<211> 21
<212> RNA
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 9
 gaugcgagau cgacgucaau  u 21

<210> 10
<211> 21
<212> RNA
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 10
 gaacggggcu aacaaagauu  u 21

<210> 11
<211> 21
<212> RNA
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 11
 gcaaggacca cuucagcgau  u 21

