                         SEQUENCE LISTING

<110>  BAYLOR COLLEGE OF MEDICINE
       Yao, Qizhi
       Li, Min
       Chen, Changyi
 
<120>  ABERRANT EXPRESSION OF ZINC TRANSPORTER ZIP4 (SLC39A4) 
       SIGNIFICANTLY CONTRIBUTES TO HUMAN PANCREATIC CANCER PATHOGENESIS
        AND PROGRESSION

<130>  HO-P03545WO0

<140>  TBA
<141>  2008-11-07

<150>  60/986,716
<151>  2007-11-09

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  2192
<212>  DNA
<213>  Homo sapiens

<400>  1
agtctggccc tggacaaccc cagcaaagcc gccctcagcc agcccagaag cactgggcct       60

tggccacagc aacacccact gagcacgctg ggagctgagt atggcgtccc tggtctcgct      120

ggagctgggg ctgcttctgg ctgtgctggt ggtgacggcg acggcgtccc cgcctgctgg      180

tctgctgagc ctgctcacct ctggccaggg cgctctggat caagaggctc tgggcggcct      240

gttaaatacg ctggcggacc gtgtgcactg cgccaacggg ccgtgtggaa agtgcctgtc      300

tgtggaggac gccctgggcc tgggcgagcc tgaggggtca gggctgcccc cgggcccggt      360

cctggaggcc aggtacgtcg cccgcctcag tgccgccgcc gtcctgtacc tcagcaaccc      420

cgagggcacc tgtgaggacg ctcgggctgg cctctgggcc tctcatgcag accacctcct      480

ggccctgctc gagagcccca aggccctgac cccgggcctg agctggctgc tgcagaggat      540

gcaggcccgg gctgccggcc agacccccaa gacggcctgc gtagatatcc ctcagctgct      600

ggaggaggcg gtgggggcgg gggctccggg cagtgctggc ggcgtcctgg ctgccctgct      660

ggaccatgtc aggagcgggt cttgcttcca cgccttgccg agccctcagt acttcgtgga      720

ctttgtgttc cagcagcaca gcagcgaggt ccctatgacg ctggccgagc tgtcagcctt      780

gatgcagcgc ctgggggtgg gcagggaggc ccacagtgac cacagtcatc ggcacagggg      840

agccagcagc cgggaccctg tgcccctcat cagctccagc aacagctcca gtgtgtggga      900

cacggtatgc ctgagtgcca gggacgtgat ggctgcatat ggactgtcgg aacaggctgg      960

ggtgaccccg gaggcctggg cccaactgag ccctgccctg ctccaacagc agctgagtgg     1020

agcctgcacc tcccagtcca ggccccccgt ccaggaccag ctcagccagt cagagaggta     1080

tctgtacggc tccctggcca cgctgctcat ctgcctctgc gcggtctttg gcctcctgct     1140

gctgacctgc actggctgca ggggggtcac ccactacatc ctgcagacct tcctgagcct     1200

ggcagtgggt gcactcactg gggacgctgt cctgcatctg acgcccaagg tgctggggct     1260

gcatacacac agcgaagagg gcctcagccc acagcccacc tggcgcctcc tggctatgct     1320

ggccgggctc tacgccttct tcctgtttga gaacctcttc aatctcctgc tgcccaggga     1380

cccggaggac ctggaggacg ggccctgcgg ccacagcagc catagccacg ggggccacag     1440

ccacggtgtg tccctgcagc tggcacccag cgagctccgg cagcccaagc ccccccacga     1500

gggctcccgc gcagacctgg tggcggagga gagcccggag ctgctgaacc ctgagcccag     1560

gagactgagc ccagagttga ggctactgcc ctatatgatc actctgggcg acgccgtgca     1620

caacttcgcc gacgggctgg ccgtgggcgc cgccttcgcg tcctcctgga agaccgggct     1680

ggccacctcg ctggccgtgt tctgccacga gttgccacac gagctggggg acttcgccgc     1740

cttgctgcac gcggggctgt ccgtgcgcca agcactgctg ctgaacctgg cctccgcgct     1800

cacggccttc gctggtctct acgtggcact cgcggttgga gtcagcgagg agagcgaggc     1860

ctggatcctg gcagtggcca ccggcctgtt cctctacgta gcactctgcg acatgctccc     1920

ggcgatgttg aaagtacggg acccgcggcc ctggctcctc ttcctgctgc acaacgtggg     1980

cctgctgggc ggctggaccg tcctgctgct gctgtccctg tacgaggatg acatcacctt     2040

ctgataccct gccctagtcc cccacctttg acttaagatc ccacacctca caaacctaca     2100

gcccagaaac cagaagcccc tatagaggcc ccagtcccaa ctccagtaaa gacactcttg     2160

tccttggaaa aaaaaaaaaa aaaaaaaaaa aa                                   2192


<210>  2
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Leu Val Ser Leu Glu Leu Gly Leu Leu Leu Ala Val Leu 
1               5                   10                  15      


Val Val Thr Ala Thr Ala Ser Pro Pro Ala Gly Leu Leu Ser Leu Leu 
            20                  25                  30          


Thr Ser Gly Gln Gly Ala Leu Asp Gln Glu Ala Leu Gly Gly Leu Leu 
        35                  40                  45              


Asn Thr Leu Ala Asp Arg Val His Cys Ala Asn Gly Pro Cys Gly Lys 
    50                  55                  60                  


Cys Leu Ser Val Glu Asp Ala Leu Gly Leu Gly Glu Pro Glu Gly Ser 
65                  70                  75                  80  


Gly Leu Pro Pro Gly Pro Val Leu Glu Ala Arg Tyr Val Ala Arg Leu 
                85                  90                  95      


Ser Ala Ala Ala Val Leu Tyr Leu Ser Asn Pro Glu Gly Thr Cys Glu 
            100                 105                 110         


Asp Ala Arg Ala Gly Leu Trp Ala Ser His Ala Asp His Leu Leu Ala 
        115                 120                 125             


Leu Leu Glu Ser Pro Lys Ala Leu Thr Pro Gly Leu Ser Trp Leu Leu 
    130                 135                 140                 


Gln Arg Met Gln Ala Arg Ala Ala Gly Gln Thr Pro Lys Thr Ala Cys 
145                 150                 155                 160 


Val Asp Ile Pro Gln Leu Leu Glu Glu Ala Val Gly Ala Gly Ala Pro 
                165                 170                 175     


Gly Ser Ala Gly Gly Val Leu Ala Ala Leu Leu Asp His Val Arg Ser 
            180                 185                 190         


Gly Ser Cys Phe His Ala Leu Pro Ser Pro Gln Tyr Phe Val Asp Phe 
        195                 200                 205             


Val Phe Gln Gln His Ser Ser Glu Val Pro Met Thr Leu Ala Glu Leu 
    210                 215                 220                 


Ser Ala Leu Met Gln Arg Leu Gly Val Gly Arg Glu Ala His Ser Asp 
225                 230                 235                 240 


His Ser His Arg His Arg Gly Ala Ser Ser Arg Asp Pro Val Pro Leu 
                245                 250                 255     


Ile Ser Ser Ser Asn Ser Ser Ser Val Trp Asp Thr Val Cys Leu Ser 
            260                 265                 270         


Ala Arg Asp Val Met Ala Ala Tyr Gly Leu Ser Glu Gln Ala Gly Val 
        275                 280                 285             


Thr Pro Glu Ala Trp Ala Gln Leu Ser Pro Ala Leu Leu Gln Gln Gln 
    290                 295                 300                 


Leu Ser Gly Ala Cys Thr Ser Gln Ser Arg Pro Pro Val Gln Asp Gln 
305                 310                 315                 320 


Leu Ser Gln Ser Glu Arg Tyr Leu Tyr Gly Ser Leu Ala Thr Leu Leu 
                325                 330                 335     


Ile Cys Leu Cys Ala Val Phe Gly Leu Leu Leu Leu Thr Cys Thr Gly 
            340                 345                 350         


Cys Arg Gly Val Thr His Tyr Ile Leu Gln Thr Phe Leu Ser Leu Ala 
        355                 360                 365             


Val Gly Ala Leu Thr Gly Asp Ala Val Leu His Leu Thr Pro Lys Val 
    370                 375                 380                 


Leu Gly Leu His Thr His Ser Glu Glu Gly Leu Ser Pro Gln Pro Thr 
385                 390                 395                 400 


Trp Arg Leu Leu Ala Met Leu Ala Gly Leu Tyr Ala Phe Phe Leu Phe 
                405                 410                 415     


Glu Asn Leu Phe Asn Leu Leu Leu Pro Arg Asp Pro Glu Asp Leu Glu 
            420                 425                 430         


Asp Gly Pro Cys Gly His Ser Ser His Ser His Gly Gly His Ser His 
        435                 440                 445             


Gly Val Ser Leu Gln Leu Ala Pro Ser Glu Leu Arg Gln Pro Lys Pro 
    450                 455                 460                 


Pro His Glu Gly Ser Arg Ala Asp Leu Val Ala Glu Glu Ser Pro Glu 
465                 470                 475                 480 


Leu Leu Asn Pro Glu Pro Arg Arg Leu Ser Pro Glu Leu Arg Leu Leu 
                485                 490                 495     


Pro Tyr Met Ile Thr Leu Gly Asp Ala Val His Asn Phe Ala Asp Gly 
            500                 505                 510         


Leu Ala Val Gly Ala Ala Phe Ala Ser Ser Trp Lys Thr Gly Leu Ala 
        515                 520                 525             


Thr Ser Leu Ala Val Phe Cys His Glu Leu Pro His Glu Leu Gly Asp 
    530                 535                 540                 


Phe Ala Ala Leu Leu His Ala Gly Leu Ser Val Arg Gln Ala Leu Leu 
545                 550                 555                 560 


Leu Asn Leu Ala Ser Ala Leu Thr Ala Phe Ala Gly Leu Tyr Val Ala 
                565                 570                 575     


Leu Ala Val Gly Val Ser Glu Glu Ser Glu Ala Trp Ile Leu Ala Val 
            580                 585                 590         


Ala Thr Gly Leu Phe Leu Tyr Val Ala Leu Cys Asp Met Leu Pro Ala 
        595                 600                 605             


Met Leu Lys Val Arg Asp Pro Arg Pro Trp Leu Leu Phe Leu Leu His 
    610                 615                 620                 


Asn Val Gly Leu Leu Gly Gly Trp Thr Val Leu Leu Leu Leu Ser Leu 
625                 630                 635                 640 


Tyr Glu Asp Asp Ile Thr Phe 
                645         


<210>  3
<211>  1944
<212>  DNA
<213>  Homo sapiens

<400>  3
atggcgtccc tggtctcgct ggagctgggg ctgcttctgg ctgtgctggt ggtgacggcg       60

acggcgtccc cgcctgctgg tctgctgagc ctgctcacct ctggccaggg cgctctggat      120

caagaggctc tgggcggcct gttaaatacg ctggcggacc gtgtgcactg cgccaacggg      180

ccgtgtggaa agtgcctgtc tgtggaggac gccctgggcc tgggcgagcc tgaggggtca      240

gggctgcccc cgggcccggt cctggaggcc aggtacgtcg cccgcctcag tgccgccgcc      300

gtcctgtacc tcagcaaccc cgagggcacc tgtgaggacg ctcgggctgg cctctgggcc      360

tctcatgcag accacctcct ggccctgctc gagagcccca aggccctgac cccgggcctg      420

agctggctgc tgcagaggat gcaggcccgg gctgccggcc agacccccaa gacggcctgc      480

gtagatatcc ctcagctgct ggaggaggcg gtgggggcgg gggctccggg cagtgctggc      540

ggcgtcctgg ctgccctgct ggaccatgtc aggagcgggt cttgcttcca cgccttgccg      600

agccctcagt acttcgtgga ctttgtgttc cagcagcaca gcagcgaggt ccctatgacg      660

ctggccgagc tgtcagcctt gatgcagcgc ctgggggtgg gcagggaggc ccacagtgac      720

cacagtcatc ggcacagggg agccagcagc cgggaccctg tgcccctcat cagctccagc      780

aacagctcca gtgtgtggga cacggtatgc ctgagtgcca gggacgtgat ggctgcatat      840

ggactgtcgg aacaggctgg ggtgaccccg gaggcctggg cccaactgag ccctgccctg      900

ctccaacagc agctgagtgg agcctgcacc tcccagtcca ggccccccgt ccaggaccag      960

ctcagccagt cagagaggta tctgtacggc tccctggcca cgctgctcat ctgcctctgc     1020

gcggtctttg gcctcctgct gctgacctgc actggctgca ggggggtcac ccactacatc     1080

ctgcagacct tcctgagcct ggcagtgggt gcactcactg gggacgctgt cctgcatctg     1140

acgcccaagg tgctggggct gcatacacac agcgaagagg gcctcagccc acagcccacc     1200

tggcgcctcc tggctatgct ggccgggctc tacgccttct tcctgtttga gaacctcttc     1260

aatctcctgc tgcccaggga cccggaggac ctggaggacg ggccctgcgg ccacagcagc     1320

catagccacg ggggccacag ccacggtgtg tccctgcagc tggcacccag cgagctccgg     1380

cagcccaagc ccccccacga gggctcccgc gcagacctgg tggcggagga gagcccggag     1440

ctgctgaacc ctgagcccag gagactgagc ccagagttga ggctactgcc ctatatgatc     1500

actctgggcg acgccgtgca caacttcgcc gacgggctgg ccgtgggcgc cgccttcgcg     1560

tcctcctgga agaccgggct ggccacctcg ctggccgtgt tctgccacga gttgccacac     1620

gagctggggg acttcgccgc cttgctgcac gcggggctgt ccgtgcgcca agcactgctg     1680

ctgaacctgg cctccgcgct cacggccttc gctggtctct acgtggcact cgcggttgga     1740

gtcagcgagg agagcgaggc ctggatcctg gcagtggcca ccggcctgtt cctctacgta     1800

gcactctgcg acatgctccc ggcgatgttg aaagtacggg acccgcggcc ctggctcctc     1860

ttcctgctgc acaacgtggg cctgctgggc ggctggaccg tcctgctgct gctgtccctg     1920

tacgaggatg acatcacctt ctga                                            1944


<210>  4
<211>  2342
<212>  DNA
<213>  Homo sapiens

<400>  4
cggcagcaaa gggccctggg caaactccag gaggcggagg aggctagtgg cagtacctgg       60

gcaccctgac cctccccaca ggccagagcc caccctcctg ctcatgaggg cagacaggcc      120

tttccaggga cacagtccct cttctcccca ggaccccagg gccaactccc cctgccggcc      180

ctctgccatc aaattggcag tggctccagg ggagtcccct ggggatgggg gaccactgtt      240

ggggacccct ctgcgtgcac ccctgtagtt ggggaagcag gacaggggcc tggggagacg      300

gaagggcgcc aggggttgag agaggatggt ggacgttgtt ggacttgaaa gggaaacagg      360

ccctcgggga agcccctggc caggcctgcc tctcccctcc ctggtgggcc cagcgcccct      420

gctcacttgt ctctgcccac agtgcctgtc tgtggaggac gccctgggcc tgggcgagcc      480

tgaggggtca gggctgcccc cgggcccggt cctggaggcc aggtacgtcg cccgcctcag      540

tgccgccgcc gtcctgtacc tcagcaaccc cgagggcacc tgtgaggacg ctcgggctgg      600

cctctgggcc tctcatgcag accacctcct ggccctgctc gagagcccca aggccctgac      660

cccgggcctg agctggctgc tgcagaggat gcaggcccgg gctgccggcc agacccccaa      720

gacggcctgc gtagatatcc ctcagctgct ggaggaggcg gtgggggcgg gggctccggg      780

cagtgctggc ggcgtcctgg ctgccctgct ggaccatgtc aggagcgggt cttgcttcca      840

cgccttgccg agccctcagt acttcgtgga ctttgtgttc cagcagcaca gcagcgaggt      900

ccctatgacg ctggccgagc tgtcagcctt gatgcagcgc ctgggggtgg gcagggaggc      960

ccacagtgac cacagtcatc ggcacagggg agccagcagc cgggaccctg tgcccctcat     1020

cagctccagc aacagctcca gtgtgtggga cacggtatgc ctgagtgcca gggacgtgat     1080

ggctgcatat ggactgtcgg aacaggctgg ggtgaccccg gaggcctggg cccaactgag     1140

ccctgccctg ctccaacagc agctgagtgg agcctgcacc tcccagtcca ggccccccgt     1200

ccaggaccag ctcagccagt cagagaggta tctgtacggc tccctggcca cgctgctcat     1260

ctgcctctgc gcggtctttg gcctcctgct gctgacctgc actggctgca ggggggtcac     1320

ccactacatc ctgcagacct tcctgagcct ggcagtgggt gcactcactg gggacgctgt     1380

cctgcatctg acgcccaagg tgctggggct gcatacacac agcgaagagg gcctcagccc     1440

acagcccacc tggcgcctcc tggctatgct ggccgggctc tacgccttct tcctgtttga     1500

gaacctcttc aatctcctgc tgcccaggga cccggaggac ctggaggacg ggccctgcgg     1560

ccacagcagc catagccacg ggggccacag ccacggtgtg tccctgcagc tggcacccag     1620

cgagctccgg cagcccaagc ccccccacga gggctcccgc gcagacctgg tggcggagga     1680

gagcccggag ctgctgaacc ctgagcccag gagactgagc ccagagttga ggctactgcc     1740

ctatatgatc actctgggcg acgccgtgca caacttcgcc gacgggctgg ccgtgggcgc     1800

cgccttcgcg tcctcctgga agaccgggct ggccacctcg ctggccgtgt tctgccacga     1860

gttgccacac gagctggggg acttcgccgc cttgctgcac gcggggctgt ccgtgcgcca     1920

agcactgctg ctgaacctgg cctccgcgct cacggccttc gctggtctct acgtggcact     1980

cgcggttgga gtcagcgagg agagcgaggc ctggatcctg gcagtggcca ccggcctgtt     2040

cctctacgta gcactctgcg acatgctccc ggcgatgttg aaagtacggg acccgcggcc     2100

ctggctcctc ttcctgctgc acaacgtggg cctgctgggc ggctggaccg tcctgctgct     2160

gctgtccctg tacgaggatg acatcacctt ctgataccct gccctagtcc cccacctttg     2220

acttaagatc ccacacctca caaacctaca gcccagaaac cagaagcccc tatagaggcc     2280

ccagtcccaa ctccagtaaa gacactcttg tccttggaaa aaaaaaaaaa aaaaaaaaaa     2340

aa                                                                    2342


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer sense

<400>  5
atgtcaggag cgggtcttgc                                                   20


<210>  6
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer antisense

<400>  6
gctgctgtgc tgctggaac                                                    19


<210>  7
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  7
tgtccgtgcg ccaagcactg ctgctgaac                                         29


<210>  8
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  8
ggagagcgag gcctggatcc tggcagtgg                                         29


<210>  9
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
acgtagcact ctgcgacatg gtcaggatg                                         29


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial primer

<400>  10
ctggaacggt gaaggtgaca                                                   20


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  artificial primer

<400>  11
aagggacttc ctgtaacaat gca                                               23


<210>  12
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  12
ctgctcagga aacagctatg ac                                                22


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  frward primer

<400>  13
ctcgtgtaaa acgacggcca gt                                                22


<210>  14
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  14
agagattgcc tgacgtcaga cagctag                                           27


<210>  15
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  15
ctgagctctc caaggcagag actct                                             25


<210>  16
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  16
actcgagatc atgggaaaat cccac                                             25


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  17
atgctaaagg tggtcacatt                                                   20


<210>  18
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  18
gctgactaca ctggcagaga aactcttgg                                         29


<210>  19
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  19
tggaacacca gctcctgtgc tgcgaagtg                                         29


<210>  20
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  20
tctgtggaga atgtcttggc tctaggcaa                                         29


