                              Sequence Listing

<110> Yan, Minhong

<120> ACTIVIN RECEPTOR-LIKE KINASE-1 COMPOSITIONS AND 
      METHODS OF USE

<130> P4042R1


<150> US 60/986,876
<151> 2007-11-09

<150> US 61/098,557
<151> 2008-09-19

<160> 10

<210> 1
<211> 1059
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 1
 atgaccttgg gctcccccag gaaaggcctt ctgatgctgc tgatggcctt 50

 ggtgacccag ggagaccctg tgaagccgtc tcggggcccg ctggtgacct 100

 gcacgtgtga gagcccacat tgcaaggggc ctacctgccg gggggcctgg 150

 tgcacagtag tgctggtgcg ggaggagggg aggcaccccc aggaacatcg 200

 gggctgcggg aacttgcaca gggagctctg cagggggcgc cccaccgagt 250

 tcgtcaacca ctactgctgc gacagccacc tctgcaacca caacgtgtcc 300

 ctggtgctgg aggccaccca acctccttcg gagcagccgg gaacagatgg 350

 ccagaccggt gtcaccgaca aagctgcgca ctatactctg tgcccaccgt 400

 gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca 450

 aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt 500

 ggtggtggcc gtgagccacg aagaccctga ggtcaagttc aactggtacg 550

 tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 600

 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga 650

 ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc 700

 cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa 750

 ccacaggtgt acaccctgcc cccatcccgg gaagagatga ccaagaacca 800

 ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc gacatcgccg 850

 tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 900

 cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt 950

 ggacaagagc aggtggcagc aggggaacgt cttctcatgc tccgtgatgc 1000

 atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg 1050

 ggtaaatga 1059

<210> 2
<211> 352
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 2
 Met Thr Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met
   1               5                  10                  15

 Ala Leu Val Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro
                  20                  25                  30

 Leu Val Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr
                  35                  40                  45

 Cys Arg Gly Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly
                  50                  55                  60

 Arg His Pro Gln Glu His Arg Gly Cys Gly Asn Leu His Arg Glu
                  65                  70                  75

 Leu Cys Arg Gly Arg Pro Thr Glu Phe Val Asn His Tyr Cys Cys
                  80                  85                  90

 Asp Ser His Leu Cys Asn His Asn Val Ser Leu Val Leu Glu Ala
                  95                 100                 105

 Thr Gln Pro Pro Ser Glu Gln Pro Gly Thr Asp Gly Gln Thr Gly
                 110                 115                 120

 Val Thr Asp Lys Ala Ala His Tyr Thr Leu Cys Pro Pro Cys Pro
                 125                 130                 135

 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
                 140                 145                 150

 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
                 155                 160                 165

 Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe
                 170                 175                 180

 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
                 185                 190                 195

 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
                 200                 205                 210

 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
                 215                 220                 225

 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                 230                 235                 240

 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
                 245                 250                 255

 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
                 260                 265                 270

 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
                 275                 280                 285

 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                 290                 295                 300

 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                 305                 310                 315

 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                 320                 325                 330

 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
                 335                 340                 345

 Leu Ser Leu Ser Pro Gly Lys
                 350        

<210> 3
<211> 1051
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 3
 atgaccttgg gctcccccag gaaaggcctt ctgatgctgc tgatggcctt 50

 ggtgacccag ggagaccctg tgaagccgtc tcggggcccg ctggtgacct 100

 gcacgtgtga gagcccacat tgcaaggggc ctacctgccg gggggcctgg 150

 tgcacagtag tgctggtgcg ggaggagggg aggcaccccc aggaacatcg 200

 gggctgcggg aacttgcaca gggagctctg cagggggcgc cccaccgagt 250

 tcgtcaacca ctactgctgc gacagccacc tctgcaacca caacgtgtcc 300

 ctggtgctgg aggccaccca acctccttcg gagcagccgg gaacagatgg 350

 ccagaccggt gtcaccgaca aaactcacac atgcccaccg tgcccagcac 400

 ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 450

 gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga 500

 cgtgagccac gaagaccctg aggtcaagtt caactggtac gtggacggcg 550

 tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 600

 acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa 650

 tggcaaggag tacaagtgca aggtctccaa caaagccctc ccagccccca 700

 tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 750

 tacaccctgc ccccatcccg ggaagagatg accaagaacc aggtcagcct 800

 gacctgcctg gtcaaaggct tctatcccag cgacatcgcc gtggagtggg 850

 agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 900

 gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag 950

 caggtggcag caggggaacg tcttctcatg ctccgtgatg catgaggctc 1000

 tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaatga 1050

 g 1051

<210> 4
<211> 349
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 4
 Met Thr Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met
   1               5                  10                  15

 Ala Leu Val Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro
                  20                  25                  30

 Leu Val Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr
                  35                  40                  45

 Cys Arg Gly Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly
                  50                  55                  60

 Arg His Pro Gln Glu His Arg Gly Cys Gly Asn Leu His Arg Glu
                  65                  70                  75

 Leu Cys Arg Gly Arg Pro Thr Glu Phe Val Asn His Tyr Cys Cys
                  80                  85                  90

 Asp Ser His Leu Cys Asn His Asn Val Ser Leu Val Leu Glu Ala
                  95                 100                 105

 Thr Gln Pro Pro Ser Glu Gln Pro Gly Thr Asp Gly Gln Thr Gly
                 110                 115                 120

 Val Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
                 125                 130                 135

 Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
                 140                 145                 150

 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
                 155                 160                 165

 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
                 170                 175                 180

 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                 185                 190                 195

 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
                 200                 205                 210

 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
                 215                 220                 225

 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
                 230                 235                 240

 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
                 245                 250                 255

 Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
                 260                 265                 270

 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
                 275                 280                 285

 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
                 290                 295                 300

 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
                 305                 310                 315

 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
                 320                 325                 330

 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
                 335                 340                 345

 Ser Pro Gly Lys
                

<210> 5
<211> 1044
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 5
 atgaccttgg gctcccccag gaaaggcctt ctgatgctgc tgatggcctt 50

 ggtgacccag ggagaccctg tgaagccgtc tcggggcccg ctggtgacct 100

 gcacgtgtga gagcccacat tgcaaggggc ctacctgccg gggggcctgg 150

 tgcacagtag tgctggtgcg ggaggagggg aggcaccccc aggaacatcg 200

 gggctgcggg aacttgcaca gggagctctg cagggggcgc cccaccgagt 250

 tcgtcaacca ctactgctgc gacagccacc tctgcaacca caacgtgtcc 300

 ctggtgctgg aggccaccca acctccttcg gagcagccgg gaacagatgg 350

 ccagaccggt gacaaaactc acacatgccc accgtgccca gcacctgaac 400

 tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc 450

 ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggccgtgag 500

 ccacgaagac cctgaggtca agttcaactg gtacgtggac ggcgtggagg 550

 tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 600

 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa 650

 ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga 700

 aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc 750

 ctgcccccat cccgggaaga gatgaccaag aaccaggtca gcctgacctg 800

 cctggtcaaa ggcttctatc ccagcgacat cgccgtggag tgggagagca 850

 atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 900

 gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg 950

 gcagcagggg aacgtcttct catgctccgt gatgcatgag gctctgcaca 1000

 accactacac gcagaagagc ctctccctgt ctccgggtaa  atga 1044

<210> 6
<211> 347
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 6
 Met Thr Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met
   1               5                  10                  15

 Ala Leu Val Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro
                  20                  25                  30

 Leu Val Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr
                  35                  40                  45

 Cys Arg Gly Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly
                  50                  55                  60

 Arg His Pro Gln Glu His Arg Gly Cys Gly Asn Leu His Arg Glu
                  65                  70                  75

 Leu Cys Arg Gly Arg Pro Thr Glu Phe Val Asn His Tyr Cys Cys
                  80                  85                  90

 Asp Ser His Leu Cys Asn His Asn Val Ser Leu Val Leu Glu Ala
                  95                 100                 105

 Thr Gln Pro Pro Ser Glu Gln Pro Gly Thr Asp Gly Gln Thr Gly
                 110                 115                 120

 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
                 125                 130                 135

 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                 140                 145                 150

 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala
                 155                 160                 165

 Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
                 170                 175                 180

 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
                 185                 190                 195

 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                 200                 205                 210

 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                 215                 220                 225

 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
                 230                 235                 240

 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
                 245                 250                 255

 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
                 260                 265                 270

 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
                 275                 280                 285

 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
                 290                 295                 300

 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                 305                 310                 315

 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
                 320                 325                 330

 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
                 335                 340                 345

 Gly Lys
        

<210> 7
<211> 1053
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 7
 atgaccttgg gctcccccag gaaaggcctt ctgatgctgc tgatggcctt 50

 ggtgacccag ggagaccctg tgaagccgtc tcggggcccg ctggtgacct 100

 gcacgtgtga gagcccacat tgcaaggggc ctacctgccg gggggcctgg 150

 tgcacagtag tgctggtgcg ggaggagggg aggcaccccc aggaacatcg 200

 gggctgcggg aacttgcaca gggagctctg cagggggcgc cccaccgagt 250

 tcgtcaacca ctactgctgc gacagccacc tctgcaacca caacgtgtcc 300

 ctggtgctgg aggccaccca acctccttcg gagcagccgg gaacagatgg 350

 ccaggagccc aaatcttgtg acaaaactca cacatgccca ccgtgcccag 400

 cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc 450

 aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt 500

 ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg 550

 gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 600

 agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct 650

 gaatggcaag gagtacaagt gcaaggtctc caacaaagcc ctcccagccc 700

 ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag 750

 gtgtacaccc tgcccccatc ccgggaagag atgaccaaga accaggtcag 800

 cctgacctgc ctggtcaaag gcttctatcc cagcgacatc gccgtggagt 850

 gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 900

 ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa 950

 gagcaggtgg cagcagggga acgtcttctc atgctccgtg atgcatgagg 1000

 ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa 1050

 tga 1053

<210> 8
<211> 350
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 8
 Met Thr Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met
   1               5                  10                  15

 Ala Leu Val Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro
                  20                  25                  30

 Leu Val Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr
                  35                  40                  45

 Cys Arg Gly Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly
                  50                  55                  60

 Arg His Pro Gln Glu His Arg Gly Cys Gly Asn Leu His Arg Glu
                  65                  70                  75

 Leu Cys Arg Gly Arg Pro Thr Glu Phe Val Asn His Tyr Cys Cys
                  80                  85                  90

 Asp Ser His Leu Cys Asn His Asn Val Ser Leu Val Leu Glu Ala
                  95                 100                 105

 Thr Gln Pro Pro Ser Glu Gln Pro Gly Thr Asp Gly Gln Glu Pro
                 110                 115                 120

 Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
                 125                 130                 135

 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
                 140                 145                 150

 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                 155                 160                 165

 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
                 170                 175                 180

 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                 185                 190                 195

 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
                 200                 205                 210

 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
                 215                 220                 225

 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
                 230                 235                 240

 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
                 245                 250                 255

 Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
                 260                 265                 270

 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
                 275                 280                 285

 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
                 290                 295                 300

 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                 305                 310                 315

 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
                 320                 325                 330

 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                 335                 340                 345

 Leu Ser Pro Gly Lys
                 350

<210> 9
<211> 1054
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 9
 atgaccttgg gctcccccag gaaaggcctt ctgatgctgc tgatggcctt 50

 ggtgacccag ggagaccctg tgaagccgtc tcggggcccg ctggtgacct 100

 gcacgtgtga gagcccacat tgcaaggggc ctacctgccg gggggcctgg 150

 tgcacagtag tgctggtgcg ggaggagggg aggcaccccc aggaacatcg 200

 gggctgcggg aacttgcaca gggagctctg cagggggcgc cccaccgagt 250

 tcgtcaacca ctactgctgc gacagccacc tctgcaacca caacgtgtcc 300

 ctggtgctgg aggccaccca acctccttcg gagcagccgg gaacagatgg 350

 ccaggagccc aaatcttctg acaaaactca cacatgccca ccgtgcccag 400

 cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc 450

 aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt 500

 ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg 550

 gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 600

 agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct 650

 gaatggcaag gagtacaagt gcaaggtctc caacaaagcc ctcccagccc 700

 ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag 750

 gtgtacaccc tgcccccatc ccgggaagag atgaccaaga accaggtcag 800

 cctgacctgc ctggtcaaag gcttctatcc cagcgacatc gccgtggagt 850

 gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 900

 ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa 950

 gagcaggtgg cagcagggga acgtcttctc atgctccgtg atgcatgagg 1000

 ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa 1050

 tgag 1054

<210> 10
<211> 350
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 10
 Met Thr Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met
   1               5                  10                  15

 Ala Leu Val Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro
                  20                  25                  30

 Leu Val Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr
                  35                  40                  45

 Cys Arg Gly Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly
                  50                  55                  60

 Arg His Pro Gln Glu His Arg Gly Cys Gly Asn Leu His Arg Glu
                  65                  70                  75

 Leu Cys Arg Gly Arg Pro Thr Glu Phe Val Asn His Tyr Cys Cys
                  80                  85                  90

 Asp Ser His Leu Cys Asn His Asn Val Ser Leu Val Leu Glu Ala
                  95                 100                 105

 Thr Gln Pro Pro Ser Glu Gln Pro Gly Thr Asp Gly Gln Glu Pro
                 110                 115                 120

 Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
                 125                 130                 135

 Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
                 140                 145                 150

 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
                 155                 160                 165

 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
                 170                 175                 180

 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                 185                 190                 195

 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
                 200                 205                 210

 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
                 215                 220                 225

 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
                 230                 235                 240

 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
                 245                 250                 255

 Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
                 260                 265                 270

 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
                 275                 280                 285

 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
                 290                 295                 300

 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                 305                 310                 315

 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
                 320                 325                 330

 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
                 335                 340                 345

 Leu Ser Pro Gly Lys
                 350

