                         SEQUENCE LISTING

<110>  Centocor, Inc. 
	 Heavner, George
 
<120>  SEMI-SYNTHETIC GLP-1 PEPTIDE-FC FUSION CONSTRUCTS, METHODS AND 
       USES

<130>  CEN5202PCT

<140>  TO BE ASSIGNED
<141>  2008-11-03


<150>  60/984,862
<151>  2007-11-02

<160>  8     

<170>  PatentIn version 3.3

<210>  1
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Ala, may be D isomer in synthetically produced peptide

<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  Gly or decarboxymethylated to form the amide.

<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  Gly, Gly-amide, or decarboxymethylated to form the amide.

<400>  1

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Xaa 
            20                  25                  30      


<210>  2
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Analogs of human GLP-1


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Ala, Gly, Ser, Thr, Leu, Ile, Val, Glu, Asp, or Lys

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Glu, Asp, or Lys

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Thr, Ala, Gly, Ser, Leu, Ile, Val, Arg, His, Glu, Asp, or Lys

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Phe, His, Trp, or Tyr

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Thr or Asn

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Ser, Ala, Gly, Thr, Leu, Ile, Val, Glu, Asp

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Asp or Glu

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Val, Ala, Gly, Ser, Thr, Leu, Ile, Met, Tyr, Trp, His, Phe, Glu, 
       Asp

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Ser, Val, Ala, Gly, Thr, Leu, Ile, Glu, Asp, or Lys

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Ser, Val, Ala, Gly, Thr, Leu, Ile, Glu, Asp or Lys

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Tyr, Phe, Trp, Glu, Asp or Lys

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Leu, Ala, Met, Gly, Ser, Thr, Leu, Ile, Val, Glu, Asp or Lys

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Glu, Ala, Thr, Ser, Gly, Gln, Asp or Lys

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Gly, Ala, Ser, Thr, Leu, Ile, Val, Gln, Asn, Arg, Cys, Glu, Asp 
       or Lys

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Gln, Asn, Arg, His, Glu, Asp or Lys

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  Ala, Gly, Ser, Thr, Leu, Ile, Val, Arg, Glu, Asp or Lys

<220>
<221>  VARIANT
<222>  (19)..(19)
<223>  Ala, Gly, Ser, Thr, Leu, Ile, Val, Met, Glu, Asp or Lys

<220>
<221>  VARIANT
<222>  (20)..(20)
<223>  Lys, Arg, His, Gln, Trp, Tyr, Phe, Glu or Asp

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  Glu, Leu, Ala, His, Phe, Tyr, Trp, Arg, Gln, Thr, Ser, Gly, Asp 
       or Lys

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Ile, Ala, Val, Leu or Glu

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Ala, Gly, Ser, Thr, Leu, Ile, Val, His, Glu, Asp or Lys

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (26)..(26)
<223>  Leu, Gly, Ala, Ser, Thr, Ile, Val, Glu, Asp or Lys

<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  Val, Leu, Gly, Ala, Ser, Thr, Ile, Arg, Glu, Asp or Lys

<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  Lys, Asn, Arg, His, Glu or Asp

<220>
<221>  VARIANT
<222>  (29)..(29)
<223>  Gly, Ala, Ser, Thr, Leu, Ile, Val, Arg, Trp, Tyr, Phe, Pro, His, 
       Glu, Asp or Lys

<220>
<221>  VARIANT
<222>  (30)..(30)
<223>  Arg, His, Thr, Ser, Trp, Tyr, Phe, Glu, Asp or Lys

<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  Gly, Ala, Ser, Thr, Leu, Ile, Val, Arg, Trp, Tyr, Phe, His, Glu, 
       Asp, Lys

<400>  2

His Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      
Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  3
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial analogis of human GLP-1


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Ala, Gly

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Glu or Asp

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Phe or Tyr

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Thr or Asn

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Ser, Thr or Ala

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Asp or Glu

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Val, Leu, Met or Ile

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Ser or Lys

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Leu, Ala or Met

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Gly, Ala, Glu or Asp

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Gln or Glu

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  Ala or Lys

<220>
<221>  VARIANT
<222>  (19)..(19)
<223>  Ala, Val, Ile, Leu or Met

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  Glu or Leu

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Ile, Ala, Val, Leu or Glu

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  Val or Lys

<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  Lys or Asn

<220>
<221>  VARIANT
<222>  (30)..(30)
<223>  Arg or Glu

<220>
<221>  misc_feature
<222>  (31)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

His Xaa Xaa Gly Thr Xaa Xaa Xaa Xaa Xaa Ser Glu Arg Xaa Thr Tyr 
1               5                   10                  15      
Arg Xaa Glu Xaa Xaa Xaa Xaa Lys Xaa Phe Xaa Ala Trp Leu Xaa Xaa 
            20                  25                  30          


Gly Xaa 
        


<210>  4
<211>  38
<212>  PRT
<213>  Heloderma suspectum


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Ser, Gly or Thr

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Asp or Glu

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Ala, ser, or Thr

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Leu, Ile, Val, pentylglycine or Met

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Ala, Leu, Ile, pentylglycine, Val

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (22)..(22)
<223>  Phe, Tyr or naphthylalanine

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Ile, Val, Leu, pentylglycine, tert-butylglycine or Met

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (25)..(25)
<223>  Ala, Trp, Phe, Tyr or naphthylalanine

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  Ala or Asn or amides thereof

<220>
<221>  misc_feature
<222>  (29)..(38)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      
Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Xaa 
        35              


<210>  5
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Structural component

<400>  5

Gly Gly Gly Lys Gly Gly Gly Gly 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Structural component

<400>  6

Gly Gly Gly Asn Gly Ser Gly Gly 
1               5               


<210>  7
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Structural component

<400>  7

Gly Gly Gly Cys Gly Gly Gly Gly Gly 
1               5                   


<210>  8
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Structural component

<400>  8

Gly Pro Asn Gly Gly 
1               5   


CEN5202PCT




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