                         SEQUENCE LISTING

<110>  Trustees of the Univertisty of Pennsylvania
       Weiser, Jeffrey
 
<120>   BACTERIA STRAINS AND BACTERIOCIN PRODUCED THEREFROM

<130>  P-70332-USP

<160>  25    

<170>  PatentIn version 3.3

<210>  1
<211>  6416
<212>  DNA
<213>  Streptococcus pneumoniae

<400>  1
attccttgga gataataaga accaccgata ttgataatag tgaccaataa gcttgagaga     60

acaatgtaag caatgagaga tttttgtttg aaatcagagg aaggaagctt agtagaccat    120

tctttttatc tttatggggt tgatagctgg gtttgggagc tagaaaaata gctactccag    180

tccattcaga gaaaaagcgt tcttttgaca ttttggtgat ttttacagaa gggtcaggat    240

caccaataac cagatagtct ttctttgttt gatagacaac atagtaatgt tggagttttt    300

cttctttgtt aacgtgaacg ataaatggat aggggacatc actcatgtca aagagagttt    360

tatctgcttg aacaggtctt gtttcaaagc ccatttcatc agcggctttt acaatgccaa    420

gagcagtcgt tccttcttta ttggtctttg caagttctct caagtgagct agagaaaaat    480

ctgaaccata gaatttagca atcgaggcta aggcagcaac accgcagtct ctcgcatcta    540

tttgaggaac aaatgtacgt ttataagaag tcattggcaa ttcctttcat atagtggata    600

ggtctattat gccataaaaa taatttcata ttttatgaaa tcttgaatag tcattgaaac    660

ttcctgaatg gtaaaaaagt gattagaaat tatctttttt caaaaaattt agaggggttt    720

tgaaagaaaa agccaattca agacgtttcg atgacaattc aagatttgga tgaaaaattt    780

taaaaaacaa tgatatacta aacttgtcaa agttgcaaca agacaaaaat taaaaataaa    840

aaaggagtat ttgttatgaa tacaaaaatg atggaacaat ttcatgaaat ggatatagct    900

atgttatcta gtattgaagg aggcaagaat aattggcaaa ctaatgtctt cgaaggtggt    960

agtgctgctt ttggtggctg ggggttaggg acagctattt gtgctgcgag tggtgtcgga   1020

gcgccattta tgggagcatg tggatacata ggagctaaat ttggtgtggc tctttgggca   1080

ggagtaacag gggcaacggg tggattttaa caaaaggaga cttgtatgaa tacttattgt   1140

aatataaatg aaacaatgct gagtgaggtt tacggaggta attccggagg agcagctgta   1200

gttgctgctt taggttgtgc agcgggtgga gtgaaatatg ggaaaattct aggaccatgg   1260

ggcgctgcaa taggaggaat tggaggagca gtggtttgtg gatatttagc ctataccgct   1320

acatcataaa aatgaaagct aaattttatg aaggctatat tctttattat tctcttcgct   1380

tttcaaacct atcttattta tctatccata agtatctctg ataaaaaaca aaagactatt   1440

gaattaacat cattgaattg ttttgtcata ttatttctaa tctatgataa attaattttt   1500

ctctttattg cctatgtttt tttgataatt tttatattaa acttgttccg taactgaaaa   1560

gtgacatact atatgaatac aaaaatgatg tcacaatttt ctgttatgga taatgaaatg   1620

cttgcttgcg ttgaaggtgg agatattgat tggggaagaa aaattagttg tgcagcaggg   1680

gttgcatatg gcgcgattga tgggtgtgca acaacggttt gacatttcta ttgggaccat   1740

ttgctatagg aataggtgta actggtgctg caggtggagc tatacttgga ggtgtagcct   1800

atgcagcaac atgttggtgg taattatgga ttttaaaagt tttattattg gtttagtagt   1860

tggtatattt ggtccttata tggatgattt aattagaaaa atattttcaa aatctcccaa   1920

aaatacagat agtaccccct aaaggaaaat aaatttctcc cctgtatttg ctagcttaat   1980

ttacagggga gtttctttaa tattgtttcg cctgtcaaaa tgatatgtga tagcaggatg   2040

aaaagtctac aaacaagttg gtatcaatac aatataaaga ggaaagtatg tttttcatgc   2100

ttacttttta aattttttaa caattcaaga ggttttgatg accatttatg atttgagtga   2160

tccaaggtca aaataagtgc tatactagca gtgtaaatgt tcttgctcaa ctaagataaa   2220

tcgcacattt aggaggaaat cttatgaaga aaaaaatact gattattttc gctctgtatc   2280

taatcatgtc catctttctt tatccgctta gggagagtat ttggtataat ctattttata   2340

ccatagccta tgtgattgca gttatgatct attttgcttt aactaaaaag aaaggagcaa   2400

agaaatgaaa acttttcttg ctaaaaaacg gaacatcttc ctttcgtttg ggggttgaag   2460

tattataaaa agtagaagtt aatgaagtat aaaagggtaa gtgttttcga aatgcttacc   2520

tttttaatga agtttttgca attcaagatg ttttgatgac catttaagat ttagatgaat   2580

ttgtaatctt aaataaggta agataaagtt aacaaatgta aaggggtatt cttatgaaga   2640

aacaaaagat aaaatcgcta ttacttgtac cacttgtatt tgcatctatt actacatgtg   2700

ttgtatatgc agaagaacag actacttctt cctctatcca ggctaatgat agttctgttg   2760

tggcaccaga tttgccatcg gctaaggaaa aggtggagca taaaccttct gttgtaaccc   2820

cagaagagta tgagaagaat gttacggact ttaaaaagat agatattgta aactgtacgt   2880

caatctttta cagaggatca attggaacat actatttatt tttgtagaaa aacttgctct   2940

cattgtcgtc aattttctcc tgaattgaaa gaatttaata acttgattga aaagaagtta   3000

gagtattatg atttggatgg taaggatttt gatggggaag cgagagagtt tctatttaaa   3060

aaatggacat ccgatatctg gatgggttgg tggcggagca actgcacaac aggtgtatga   3120

ttatatgtac tcgagaaact cacctaagca aacggagaca gtgaaatctt ctgaggaaac   3180

ggtaactgaa agtgttcgtg atgagaatac tagaagtgac agcatgagta ttagtgataa   3240

agttgtaagc gacagcaaag gtatgagtga tgaaaaaaga actgaaatga aaatatccaa   3300

tgataatccc aattctaata gtgaaaatag tgggaaagtg gagagtacaa actcaacttc   3360

tgaagctaaa actactcaat ctggcaattt agcaatgtta gacaataaga atcaattgga   3420

aactcccaaa cctatttttg atgttgctca agaaaataaa actccttcaa ctgatgttaa   3480

ggatgctgat tatgtaagtg aatctattac ttcaatgaaa attattaccg aaaacaggag   3540

aggaagaaag ttaccaactg attcggctga ctgtcgcgtt ttttatgact tctgtaatga   3600

ttaaagtgaa acaaaaaatt cataaataaa aatagatggt aaacaggtgc aatgatatta   3660

tttgtttgta ataacatatc gctaacattt gcctatagac aagagtgaaa gggcaagtat   3720

gtttttaatg cttacttttt aaatttttta acaattcaag atgtttcgat gacaattcaa   3780

gatttggatg aaaaatttta aaaaacaatg atatactaaa cttgtcaaag ttgcaacggg   3840

tgctgctaca ttatgttaaa aatcgctctt gattgataag ttggatttgt taggaaagga   3900

gtaaataatt atggataaga aaaagatagt ttcgactata atatgtatag tatttcttgt   3960

agtgtcagta gataattttt ttagagactt aaccccgtta ctgttcattt taaatattat   4020

tggcctgtct tgcttttcag tgctaacata cattaacata aaagagatac tcttaaatat   4080

aagcaaatga tgatttggtt agtcctagaa ccaatcaact tatgtttatc ggcttggtag   4140

attttatgtt tgtcatttgt ttgtatagag gtatttcaga aacagaattc tatcaacaac   4200

taatcgctta tataggtgta ttctctgctt gtttatcaca cttctgctca tgtggggctt   4260

gaagtattat aaaaagtagc tttctatcct tttctgacag gatatttgag tagaaggctc   4320

tattaaattg ttagtgaaat aaatgaatgg aggtatttaa tatgaaatac agattatttt   4380

ttgttatttt cttgagtagt gtgttggata ttcttttagg gacattttta caaatctcta   4440

tcgtatctat tgggtggctt gttctttaca gtggtttgtt tgaagcagga gttttccttc   4500

ttgctaataa aggggtggcg gtaaaaatca aggaagtaga tattcgaaat cgctttaaat   4560

ttatttttgg aaaaacctta tggtttcaaa ttcttttgct catctttttg ataatcaaac   4620

tttatcttgg tttggatgcg aggttgattt tattctatgg acatattttc attgtcttta   4680

atgccttaat gtatctatta tctagtagtc aggttagcct taaaaaaaca aactgtcttc   4740

ttaatcttac agcagtagag cctgacaagg tgaggtcata gtagggagga tttctatgaa   4800

aaagtatcaa cttctattca aaataagtgc agtcttctct tacttatttt tcgtatttgg   4860

tctttctcag ctgacgctta tcgtccaaaa ttattggcaa ttttcttccc agattggtaa   4920

tttcgtctgg attcaaaata tcttgagttt actttttatt ggagtcatga ttgtggttct   4980

tgttaagaca ggccgtggtt atctcttccg cattccaaga aaaaaatggc tttggtattc   5040

gattttgaca gtattagtgg tagtgttcca gatctctttt aacgttcaga cagctaaaca   5100

tgttcagtca actgcggaag gttgggctgt attgattggt tatagtggga ctaactttgc   5160

agagctaggt atttatatag ccctgttctt tctggttcca ctgatggaag agttaatcta   5220

tagaggatta ctgcaacatg ctttctttaa gcattcgcga tttggtcttg atttgcttct   5280

tccttctatt ttatttgctc tccctcattt ttcaagcctg cctagtctgt tagatatctt   5340

cgtctttgca acagttggaa tcatctttgc tggtttgacc cgctatacca agagcattta   5400

tccatcctat gcggtgcatg tgatcaataa tattgtagcg accttcccgt ttttgctcac   5460

ttttctacat agggtcttgg ggtaaaaaaa caaaaggctt gcttttcagc catagaggag   5520

gtcatcatgt ataaacactt atttttccta gattccaaaa ctttagatcg gttgacaccc   5580

tatattctag tcttggtttc tgacaccatt gcttttaatg tttttgtgct aacctttgta   5640

tctgcggtgg tttttaattt cctaaattcc atgctagctt taatggctat attcataggg   5700

gctggctatg tggtcggatt ttggttgcta aaatggtttg ttttggaaag gctagatcta   5760

aagaatgacg tgtaggaagt ctgtttgttg aggaggataa ttttatggag ttttttgata   5820

aatttcatgc cttgtgtttt ggatttttag tactaataat tgtcattaca gttccttata   5880

cgattaacca tggggatttt tttcaaaatg aatctgcatt gattcttgta agtcttcttg   5940

taacctcgct gagtgttgct tatgctagaa agtttgaaat gatttctttt gggatgttaa   6000

gcaagaaaca acttttgctt ttcattgcaa tctttcttct aagtgtactt gagacgctgg   6060

tttatattca tttcttcgct gtttcttctg gctcaggggt ccaacacttg gcggaagtca   6120

gcagaggaat ttccctgtct ttgattttaa ctacctcagt ttttggcccc atccaggagg   6180

aactcatttt cagaggactt cttcaaggtg cggtttttga caattcttgg ttagggcttg   6240

tgctaacttc ctctctcttt tctttcatgc atggaccttc taatgtccct tcgtttattt   6300

tttatctact tgggagtttg ttgctgggct ttgcttataa aaagagtcaa aacctatggg   6360

tttctactct agtccatatg ctttacaaca gttggccact cttaacttat ttataa       6416


<210>  2
<211>  42
<212>  PRT
<213>  Streptoccocus pneumoniae

<400>  2

Met Asp Lys Lys Gln Asn Leu Thr Ser Phe Gln Glu Leu Thr Thr Thr 
1               5                   10                  15      


Glu Leu Asn Gln Ile Thr Gly Gly Gly Leu Trp Glu Asp Leu Leu Tyr 
            20                  25                  30          


Asn Ile Asn Arg Tyr Ala His Tyr Ile Thr 
        35                  40          


<210>  3
<211>  245
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  3

Met Arg Ile Phe Val Leu Glu Asp Asp Phe Ser Gln Gln Thr Arg Ile 
1               5                   10                  15      


Glu Thr Thr Ile Glu Lys Leu Leu Lys Ala His His Ile Ile Pro Ser 
            20                  25                  30          


Ser Phe Glu Val Phe Gly Lys Pro Asp Gln Leu Leu Ala Glu Val His 
        35                  40                  45              


Glu Lys Gly Ala His Gln Leu Phe Phe Leu Asp Ile Glu Ile Arg Asn 
    50                  55                  60                  


Glu Glu Met Lys Gly Leu Glu Val Ala Arg Lys Ile Arg Asp Arg Asp 
65                  70                  75                  80  


Pro Tyr Ala Leu Ile Val Phe Val Thr Thr His Ser Glu Phe Met Pro 
                85                  90                  95      


Leu Ser Phe Arg Tyr Gln Val Ser Ala Leu Asp Tyr Ile Asp Lys Ala 
            100                 105                 110         


Leu Ser Ala Glu Glu Phe Glu Ser Arg Ile Glu Thr Ala Leu Leu Tyr 
        115                 120                 125             


Ala Asn Ser Gln Asp Ser Lys Ser Leu Ala Glu Asp Cys Phe Tyr Phe 
    130                 135                 140                 


Lys Ser Lys Phe Ala Gln Phe Gln Tyr Pro Phe Lys Glu Val Tyr Tyr 
145                 150                 155                 160 


Leu Glu Thr Ser Pro Arg Ala His Arg Val Ile Leu Tyr Thr Lys Thr 
                165                 170                 175     


Asp Arg Leu Glu Phe Thr Ala Ser Leu Glu Glu Val Phe Lys Gln Glu 
            180                 185                 190         


Pro Arg Leu Leu Gln Cys His Arg Ser Phe Leu Ile Asn Pro Ala Asn 
        195                 200                 205             


Val Val His Leu Asp Lys Lys Glu Lys Leu Leu Phe Phe Pro Asn Gly 
    210                 215                 220                 


Gly Ser Cys Leu Ile Ala Arg Tyr Lys Val Arg Glu Val Ser Glu Ala 
225                 230                 235                 240 


Ile Asn Lys Leu His 
                245 


<210>  4
<211>  446
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  4

Met Asn Ile Ala Trp Ile Leu Leu Tyr Thr Leu Val Thr Asn Gly Leu 
1               5                   10                  15      


Glu Ile Val Ile Phe Phe Lys Val Asp Gly Ile Asp Leu Thr Phe Glu 
            20                  25                  30          


Arg Ile Phe Lys Ala Phe Leu Leu Lys Ile Leu Leu Ala Phe Val Phe 
        35                  40                  45              


Val Met Ile Ser Tyr Ile Val Gly Asn Val Tyr Leu Ser Tyr Phe Met 
    50                  55                  60                  


Glu Pro Leu Tyr Gly Ile Gly Leu Ser Phe Leu Leu Leu Arg Gly Leu 
65                  70                  75                  80  


Pro Lys Lys Leu Leu Phe Phe Tyr Gly Leu Phe Pro Met Ile Leu Val 
                85                  90                  95      


Asn Leu Phe Tyr Arg Gly Val Ser Tyr Phe Val Leu Pro Phe Leu Gly 
            100                 105                 110         


Gln Gly Gln Val Tyr Asp Gly Tyr Ser Phe Thr Gly Leu Cys Ile Ile 
        115                 120                 125             


Ile Phe Asn Phe Phe Ile Ser Leu Ala Phe Leu Lys Trp Leu Asp Tyr 
    130                 135                 140                 


Asp Phe Thr Ser Leu Arg Lys Glu Ile Leu Asp Lys Ala Phe Gln Lys 
145                 150                 155                 160 


Ser Leu Thr Gln Ile Asn Trp Ile Met Gly Gly Tyr Tyr Leu Val Met 
                165                 170                 175     


Glu Ser Leu Ser Phe Phe Glu Tyr Glu Gln Ser Ile Gln Ser Lys Thr 
            180                 185                 190         


Val Arg His Leu Ile Leu Val Phe Tyr Leu Leu Phe Phe Met Gly Val 
        195                 200                 205             


Ile Lys Lys Leu Asp Thr Tyr Leu Lys Glu Lys Leu Tyr Glu Arg Leu 
    210                 215                 220                 


Glu Gln Glu Gln Ala Leu Arg Tyr Arg Asp Met Glu Arg Tyr Ser Arg 
225                 230                 235                 240 


His Ile Glu Glu Leu Tyr Lys Glu Val Arg Ser Phe Arg His Asp Tyr 
                245                 250                 255     


Thr Asn Leu Leu Thr Ser Leu Arg Leu Gly Ile Glu Glu Glu Asp Met 
            260                 265                 270         


Glu Gln Ile Lys Glu Val Tyr Gly Ser Val Leu Lys Asp Ser Ser Gln 
        275                 280                 285             


Lys Leu Gln Asn Asn Lys Tyr Asp Leu Gly Arg Leu Val Asn Ile Arg 
    290                 295                 300                 


Asp Lys Ala Leu Lys Ser Leu Leu Ala Gly Lys Phe Leu Lys Ala Arg 
305                 310                 315                 320 


Asp Lys Asn Ile Val Phe Asn Val Glu Val Pro Glu Glu Ile Gln Val 
                325                 330                 335     


Glu Gly Met Ser Leu Leu Asp Phe Leu Thr Ile Val Ser Ile Leu Cys 
            340                 345                 350         


Asp Asn Ala Ile Glu Ala Ser Val Glu Ala Ser Gln Pro His Val Ser 
        355                 360                 365             


Ile Ala Phe Leu Lys Asn Gly Ala Gln Glu Thr Phe Ile Ile Glu Asn 
    370                 375                 380                 


Ser Ile Lys Glu Glu Gly Ile Asp Ile Ser Glu Ile Phe Ser Phe Gly 
385                 390                 395                 400 


Ala Ser Ser Lys Gly Glu Glu Arg Gly Val Gly Leu Tyr Thr Val Met 
                405                 410                 415     


Lys Ile Val Glu Ser His Pro Asn Thr Ser Leu Asn Thr Thr Cys Gln 
            420                 425                 430         


Asn Gln Val Phe Arg Gln Val Leu Thr Val Ile His Thr Glu 
        435                 440                 445     


<210>  5
<211>  722
<212>  PRT
<213>  Streptococcus thermophilus

<400>  5

Met Lys Gly Phe Gly Met Phe Arg Phe Arg Arg Thr Phe Val Pro Gln 
1               5                   10                  15      


Ile Asp Met Arg Asn Cys Gly Val Ala Ala Leu Ala Leu Val Ala Lys 
            20                  25                  30          


Tyr Tyr Gly Ser Asp Tyr Ser Leu Ala His Leu Arg Glu Leu Ala Lys 
        35                  40                  45              


Thr Asn Lys Glu Gly Thr Thr Ala Leu Gly Leu Val Glu Ala Ala Lys 
    50                  55                  60                  


Lys Ile Gly Phe Glu Thr Arg Ala Ile Lys Ala Glu Met Ser Leu Phe 
65                  70                  75                  80  


Glu Met Glu Asp Val Pro Tyr Pro Phe Ile Ala His Val Asn Lys Asp 
                85                  90                  95      


Gly Lys Leu Gln His Tyr Tyr Val Ile Tyr Lys Ser Thr Lys Asp Tyr 
            100                 105                 110         


Leu Ile Ile Gly Asp Pro Asp Pro Ser Val Lys Val Thr Lys Met Thr 
        115                 120                 125             


Lys Glu Arg Phe Glu Lys Glu Trp Thr Gly Val Thr Leu Phe Met Gly 
    130                 135                 140                 


Pro Glu Pro Ser Tyr Lys Pro His Lys Asp Lys Lys Asn Gly Leu Trp 
145                 150                 155                 160 


Asp Phe Leu Pro Leu Ile Phe Lys Gln Arg Ser Leu Ile Ala Asn Ile 
                165                 170                 175     


Val Phe Ala Ser Leu Leu Val Thr Leu Ile Asn Ile Leu Gly Ser Tyr 
            180                 185                 190         


Tyr Leu Gln Gly Ile Leu Asp Glu Tyr Val Pro Asn Gln Met Lys Ser 
        195                 200                 205             


Thr Leu Gly Ile Ile Ser Ile Gly Leu Val Val Thr Tyr Val Leu Gln 
    210                 215                 220                 


Gln Met Met Thr Phe Ala Arg Asp Tyr Leu Leu Thr Ile Leu Ser Gln 
225                 230                 235                 240 


Arg Leu Thr Ile Asp Val Ile Leu Ser Tyr Ile Arg His Ile Phe Glu 
                245                 250                 255     


Leu Pro Met Ser Phe Phe Ala Thr Arg Arg Thr Gly Glu Val Ile Ser 
            260                 265                 270         


Arg Phe Ser Asp Ala Asn Ser Ile Ile Asp Ala Leu Ala Ser Thr Ile 
        275                 280                 285             


Leu Ser Leu Phe Leu Asp Phe Ser Ile Val Ile Ile Val Gly Gly Val 
    290                 295                 300                 


Leu Leu Ile Gln Asn Ser Asn Leu Phe Lys Leu Val Leu Cys Ser Val 
305                 310                 315                 320 


Pro Ile Tyr Thr Leu Ile Val Phe Ala Phe Met Lys Pro Phe Glu Leu 
                325                 330                 335     


Met Asn His Asp Val Met Gln Ser Asn Ala Met Val Asn Ser Ala Ile 
            340                 345                 350         


Ile Glu Asp Ile Asn Gly Ile Glu Thr Ile Lys Ser Leu Thr Ser Glu 
        355                 360                 365             


Glu Val Cys Tyr Gln Lys Ile Asp Gly Glu Phe Val Asp Tyr Leu Asp 
    370                 375                 380                 


Asn Ser Phe Arg Leu Ser Lys Leu Ser Ile Leu Gln Thr Ser Leu Lys 
385                 390                 395                 400 


Gln Gly Ala Gln Leu Ile Leu Asn Val Leu Ile Leu Trp Thr Gly Ala 
                405                 410                 415     


Gln Leu Val Met Gly Asn Thr Ile Ser Ile Gly Gln Leu Ile Thr Phe 
            420                 425                 430         


Asn Met Leu Leu Ser Tyr Phe Thr Asn Pro Leu Glu Asn Ile Ile Asn 
        435                 440                 445             


Leu Gln Thr Lys Leu Gln Ser Ala Lys Val Ala Asn Thr Arg Leu Asn 
    450                 455                 460                 


Glu Val Tyr Leu Ile Glu Ser Glu Phe Gly Gln Ser Asp Asp Thr Tyr 
465                 470                 475                 480 


Gln Glu Gly Ile Ala Asp Gly Asp Ile Thr Val Thr Asp Leu Ser Tyr 
                485                 490                 495     


Lys Tyr Gly Phe Gly Arg Asp Thr Leu Thr Asp Val Ser Leu Thr Ile 
            500                 505                 510         


Arg Gln Gly Glu Lys Ile Ser Phe Val Gly Val Ser Gly Ser Gly Lys 
        515                 520                 525             


Thr Thr Leu Ala Lys Met Leu Val Asn Phe Tyr Gln Pro Tyr Lys Gly 
    530                 535                 540                 


His Ile Asp Phe Asn Gly Gln Asn Ile Ser Arg Ile Asp Lys Lys Thr 
545                 550                 555                 560 


Leu Arg Gln His Ile Asn Tyr Leu Pro Gln Gln Ser Tyr Ile Phe Ser 
                565                 570                 575     


Gly Ser Val Leu Glu Asn Leu Thr Leu Gly Ala Ala Arg Gly Ile Thr 
            580                 585                 590         


Gln Ala Asp Ile Leu Lys Ala Cys Glu Ile Ala Glu Ile Arg Gln Asp 
        595                 600                 605             


Ile Glu Asn Met Pro Met Gly Phe Gln Thr Glu Leu Ser Asp Gly Ala 
    610                 615                 620                 


Gly Leu Ser Gly Gly Gln Lys Gln Arg Ile Ala Leu Ala Arg Ala Leu 
625                 630                 635                 640 


Leu Thr Lys Ser Pro Val Leu Ile Leu Asp Glu Ala Thr Ser Gly Leu 
                645                 650                 655     


Asp Val Leu Thr Glu Lys Gln Val Ile Asp Asn Leu Leu Ala Leu Lys 
            660                 665                 670         


Asp Lys Thr Ile Ile Phe Val Ala His Arg Leu Ser Ile Ala Glu Arg 
        675                 680                 685             


Thr Asp Arg Ile Val Val Ile Asp Gln Gly Arg Val Val Glu Thr Gly 
    690                 695                 700                 


Ser His Gln Asp Leu Met Ser Asn Pro Gly Phe Tyr Tyr Gln Leu Phe 
705                 710                 715                 720 


Arg Lys 
        


<210>  6
<211>  453
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  6

Met Asn Pro Asn Leu Phe Arg Ser Val Glu Phe Tyr Gln Arg Arg Tyr 
1               5                   10                  15      


His Asn Tyr Ala Thr Val Leu Ile Ile Pro Leu Ser Leu Leu Phe Thr 
            20                  25                  30          


Phe Ile Leu Ile Phe Ser Leu Val Ala Thr Lys Glu Ile Thr Val Thr 
        35                  40                  45              


Ser Gln Gly Glu Ile Ala Pro Thr Ser Val Ile Ala Ser Ile Gln Ser 
    50                  55                  60                  


Thr Ser Asp Asn Pro Ile Leu Ala Asn His Leu Val Ala Asn Gln Val 
65                  70                  75                  80  


Val Glu Lys Gly Asp Leu Leu Ile Lys Tyr Ser Glu Thr Met Glu Glu 
                85                  90                  95      


Ser Gln Lys Thr Ala Leu Ala Thr Gln Leu Gln Arg Leu Glu Lys Gln 
            100                 105                 110         


Lys Glu Gly Leu Gly Ile Leu Lys Gln Ser Leu Glu Lys Ala Thr Asp 
        115                 120                 125             


Leu Phe Ser Gly Glu Asp Glu Phe Gly Tyr His Asn Thr Phe Met Asn 
    130                 135                 140                 


Phe Thr Lys Gln Ser His Asp Ile Glu Leu Gly Ile Thr Lys Thr Asn 
145                 150                 155                 160 


Thr Glu Val Ser Asn Gln Ala Asn Leu Ser Asn Ser Ser Ser Ser Ala 
                165                 170                 175     


Ile Glu Gln Glu Ile Thr Lys Val Gln Gln Gln Ile Gly Glu Tyr Gln 
            180                 185                 190         


Glu Leu Arg Asp Ala Ile Ile Asn Asn Arg Ala Arg Leu Pro Thr Gly 
        195                 200                 205             


Asn Pro His Gln Ser Ile Leu Asn Arg Tyr Leu Val Ala Ser Gln Gly 
    210                 215                 220                 


Gln Thr Gln Gly Thr Ala Glu Glu Pro Phe Leu Ser Gln Ile Asn Gln 
225                 230                 235                 240 


Ser Ile Ala Gly Leu Glu Ser Ser Ile Ala Ser Leu Lys Ile Gln Gln 
                245                 250                 255     


Ala Gly Ile Gly Ser Val Ala Thr Tyr Asp Asn Ser Leu Ala Thr Lys 
            260                 265                 270         


Ile Glu Val Leu Arg Thr Gln Phe Leu Gln Thr Ala Ser Gln Gln Gln 
        275                 280                 285             


Leu Thr Val Glu Asn Gln Leu Thr Glu Leu Lys Val Gln Leu Asp Gln 
    290                 295                 300                 


Ala Thr Gln Arg Leu Glu Asn Asn Thr Leu Thr Ser Pro Ser Lys Gly 
305                 310                 315                 320 


Ile Val His Leu Asn Ser Glu Phe Glu Gly Lys Asn Arg Ile Pro Thr 
                325                 330                 335     


Gly Thr Glu Ile Ala Gln Ile Phe Pro Val Ile Thr Asp Thr Arg Glu 
            340                 345                 350         


Val Leu Ile Thr Tyr Tyr Val Ser Ser Asp Tyr Leu Pro Leu Leu Asp 
        355                 360                 365             


Lys Gly Gln Thr Val Arg Leu Lys Leu Glu Lys Ile Gly Asn His Gly 
    370                 375                 380                 


Thr Thr Ile Ile Gly Gln Leu Gln Thr Ile Asp Gln Thr Pro Thr Arg 
385                 390                 395                 400 


Thr Glu Gln Gly Asn Leu Phe Lys Leu Thr Ala Leu Ala Lys Leu Ser 
                405                 410                 415     


Asn Glu Asp Ser Lys Leu Ile Gln Tyr Gly Leu Gln Gly Arg Val Thr 
            420                 425                 430         


Ser Val Thr Thr Lys Lys Thr Tyr Phe Asp Tyr Phe Lys Asp Lys Ile 
        435                 440                 445             


Leu Thr His Ser Asp 
    450             


<210>  7
<211>  84
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  7

Met Asp Thr Lys Ile Met Glu Gln Phe His Glu Met Asp Ile Thr Met 
1               5                   10                  15      


Leu Ser Ser Ile Glu Gly Gly Lys Asn Asn Trp Gln Thr Asn Val Leu 
            20                  25                  30          


Glu Gly Gly Gly Ala Ala Phe Gly Gly Trp Gly Leu Gly Thr Ala Ile 
        35                  40                  45              


Cys Ala Ala Ser Gly Val Gly Ala Pro Phe Met Gly Ala Cys Gly Tyr 
    50                  55                  60                  


Ile Gly Ala Lys Phe Gly Val Asp Leu Trp Ala Gly Val Thr Gly Ala 
65                  70                  75                  80  


Thr Gly Gly Phe 
                


<210>  8
<211>  84
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  8

Met Asp Thr Lys Ile Met Glu Gln Phe His Glu Met Asp Ile Thr Met 
1               5                   10                  15      


Leu Ser Ser Ile Glu Gly Gly Lys Asn Asn Trp Gln Thr Asn Val Leu 
            20                  25                  30          


Glu Gly Gly Gly Ala Ala Phe Gly Gly Trp Gly Leu Gly Thr Ala Ile 
        35                  40                  45              


Cys Ala Ala Ser Gly Val Gly Ala Pro Phe Met Gly Ala Cys Gly Tyr 
    50                  55                  60                  


Ile Gly Ala Lys Phe Gly Val Asp Leu Trp Ala Gly Val Thr Gly Ala 
65                  70                  75                  80  


Thr Gly Gly Phe 
                


<210>  9
<211>  84
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  9

Met Asp Thr Lys Ile Met Glu Gln Phe His Glu Met Asp Ile Thr Met 
1               5                   10                  15      


Leu Ser Ser Ile Glu Gly Gly Lys Asn Asn Trp Gln Thr Asn Val Leu 
            20                  25                  30          


Glu Gly Gly Gly Ala Ala Phe Gly Gly Trp Gly Leu Gly Thr Ala Ile 
        35                  40                  45              


Cys Ala Ala Ser Gly Val Gly Ala Pro Phe Met Gly Ala Cys Gly Tyr 
    50                  55                  60                  


Ile Gly Ala Lys Phe Gly Val Ala Leu Trp Ala Gly Val Thr Gly Ala 
65                  70                  75                  80  


Thr Gly Gly Phe 
                


<210>  10
<211>  84
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  10

Met Asp Thr Lys Ile Met Glu Gln Phe His Glu Met Asp Ile Thr Met 
1               5                   10                  15      


Leu Ser Ser Ile Glu Gly Gly Lys Asn Asn Trp Gln Thr Asn Val Leu 
            20                  25                  30          


Glu Gly Gly Gly Ala Ala Phe Gly Gly Trp Gly Leu Gly Thr Ala Ile 
        35                  40                  45              


Cys Ala Ala Ser Gly Val Gly Ala Pro Phe Met Gly Ala Cys Gly Tyr 
    50                  55                  60                  


Ile Gly Ala Lys Phe Gly Val Asp Leu Trp Ala Gly Val Thr Gly Ala 
65                  70                  75                  80  


Thr Gly Gly Phe 
                


<210>  11
<211>  84
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  11

Met Asp Thr Lys Met Met Glu Gln Phe His Glu Met Asp Ile Ala Met 
1               5                   10                  15      


Leu Ser Ser Ile Glu Gly Gly Lys Asn Asn Trp Gln Thr Asn Val Phe 
            20                  25                  30          


Glu Gly Gly Ser Ala Ala Phe Gly Gly Trp Gly Leu Gly Thr Ala Ile 
        35                  40                  45              


Cys Ala Ala Ser Gly Val Gly Ala Pro Phe Met Gly Ala Cys Gly Tyr 
    50                  55                  60                  


Ile Gly Ala Lys Phe Gly Val Ala Leu Trp Ala Gly Val Thr Gly Ala 
65                  70                  75                  80  


Thr Gly Gly Phe 
                


<210>  12
<211>  84
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  12

Met Asn Thr Lys Met Met Glu Gln Phe His Glu Met Asp Ile Ala Met 
1               5                   10                  15      


Leu Ser Ser Ile Glu Gly Gly Lys Asn Asn Trp Gln Thr Asn Val Phe 
            20                  25                  30          


Glu Gly Gly Ser Ala Ala Phe Gly Gly Trp Gly Leu Gly Thr Ala Ile 
        35                  40                  45              


Cys Ala Ala Ser Gly Val Gly Ala Pro Phe Met Gly Ala Cys Gly Tyr 
    50                  55                  60                  


Ile Gly Ala Lys Phe Gly Val Ala Leu Trp Ala Gly Val Thr Gly Ala 
65                  70                  75                  80  


Thr Gly Gly Phe 
                


<210>  13
<211>  45
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  13

Ala Ala Val Val Ala Ala Leu Gly Cys Ala Ala Gly Gly Val Lys Tyr 
1               5                   10                  15      


Gly Arg Leu Leu Gly Pro Trp Gly Ala Ala Ile Gly Gly Ile Gly Gly 
            20                  25                  30          


Ala Val Val Cys Gly Tyr Leu Ala Tyr Thr Ala Thr Ser 
        35                  40                  45  


<210>  14
<211>  45
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  14

Ala Ala Val Val Ala Ala Leu Gly Cys Ala Ala Gly Gly Val Lys Tyr 
1               5                   10                  15      


Gly Lys Ile Leu Gly Pro Trp Gly Ala Ala Ile Gly Gly Ile Gly Gly 
            20                  25                  30          


Ala Val Val Cys Gly Tyr Leu Ala Tyr Thr Ala Thr Ser 
        35                  40                  45  


<210>  15
<211>  45
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  15

Ala Ala Val Val Ala Ala Leu Gly Cys Ala Ala Gly Gly Val Lys Tyr 
1               5                   10                  15      


Gly Arg Leu Leu Gly Pro Trp Gly Ala Ala Ile Gly Gly Ile Gly Gly 
            20                  25                  30          


Ala Val Val Cys Gly Tyr Leu Ala Tyr Thr Ala Thr Ser 
        35                  40                  45  


<210>  16
<211>  61
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  16

Lys Asn Asn Trp Gln Thr Asn Val Leu Glu Gly Gly Gly Ala Ala Phe 
1               5                   10                  15      


Gly Gly Trp Gly Leu Gly Thr Ala Ile Cys Ala Ala Ser Gly Val Gly 
            20                  25                  30          


Ala Pro Phe Met Gly Ala Cys Gly Tyr Ile Gly Ala Lys Phe Gly Val 
        35                  40                  45              


Ala Leu Trp Ala Gly Val Thr Gly Ala Thr Ser Gly Phe 
    50                  55                  60      


<210>  17
<211>  61
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  17

Lys Asn Asn Trp Gln Thr Asn Val Leu Glu Gly Gly Gly Ala Ala Phe 
1               5                   10                  15      


Gly Gly Trp Gly Leu Gly Thr Ala Ile Cys Ala Ala Ser Gly Val Gly 
            20                  25                  30          


Ala Pro Phe Met Gly Ala Cys Gly Tyr Ile Gly Ala Lys Phe Gly Val 
        35                  40                  45              


Asp Leu Trp Ala Gly Val Thr Gly Ala Thr Gly Gly Phe 
    50                  55                  60      


<210>  18
<211>  61
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  18

Lys Asn Asn Trp Gln Thr Asn Val Phe Glu Gly Gly Ser Ala Ala Phe 
1               5                   10                  15      


Gly Gly Trp Gly Leu Gly Thr Ala Ile Cys Ala Ala Ser Gly Val Gly 
            20                  25                  30          


Ala Pro Phe Met Gly Ala Cys Gly Tyr Ile Gly Ala Lys Phe Gly Val 
        35                  40                  45              


Ala Leu Trp Ala Gly Val Thr Gly Ala Thr Gly Gly Phe 
    50                  55                  60      


<210>  19
<211>  84
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  19

Met Asp Thr Lys Ile Met Glu Gln Phe His Glu Met Asp Ile Thr Met 
1               5                   10                  15      


Leu Ser Ser Ile Glu Gly Gly Lys Asn Asn Trp Gln Thr Asn Val Leu 
            20                  25                  30          


Glu Gly Gly Gly Ala Ala Phe Gly Gly Trp Gly Leu Gly Thr Ala Ile 
        35                  40                  45              


Cys Ala Ala Ser Gly Val Gly Ala Pro Phe Met Gly Ala Cys Gly Tyr 
    50                  55                  60                  


Ile Gly Ala Lys Phe Gly Val Asp Leu Trp Ala Gly Val Thr Gly Ala 
65                  70                  75                  80  


Thr Gly Gly Phe 
                


<210>  20
<211>  393
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  20

Met Lys His Leu Lys Thr Phe Tyr Lys Lys Trp Phe Gln Leu Leu Val 
1               5                   10                  15      


Val Ile Val Ile Ser Phe Phe Ser Gly Ala Leu Gly Ser Phe Ser Ile 
            20                  25                  30          


Thr Gln Leu Thr Gln Lys Ser Ser Val Asn Asn Ser Asn Asn Asn Ser 
        35                  40                  45              


Thr Ile Thr Gln Thr Ala Tyr Lys Asn Glu Asn Ser Thr Thr Gln Ala 
    50                  55                  60                  


Val Asn Lys Val Lys Asp Ala Val Val Ser Val Ile Thr Tyr Ser Ala 
65                  70                  75                  80  


Asn Arg Gln Asn Ser Val Phe Gly Asn Asp Asp Thr Asp Thr Asp Ser 
                85                  90                  95      


Gln Arg Ile Ser Ser Glu Gly Ser Gly Val Ile Tyr Lys Lys Asn Asp 
            100                 105                 110         


Lys Glu Ala Tyr Ile Val Thr Asn Asn His Val Ile Asn Gly Ala Ser 
        115                 120                 125             


Lys Val Asp Ile Arg Leu Ser Asp Gly Thr Lys Val Pro Gly Glu Ile 
    130                 135                 140                 


Val Gly Ala Asp Thr Phe Ser Asp Ile Ala Val Val Lys Ile Ser Ser 
145                 150                 155                 160 


Glu Lys Val Thr Thr Val Ala Glu Phe Gly Asp Ser Ser Lys Leu Thr 
                165                 170                 175     


Val Gly Glu Thr Ala Ile Ala Ile Gly Ser Pro Leu Gly Ser Glu Tyr 
            180                 185                 190         


Ala Asn Thr Val Thr Gln Gly Ile Val Ser Ser Leu Asn Arg Asn Val 
        195                 200                 205             


Ser Leu Lys Ser Glu Asp Gly Gln Ala Ile Ser Thr Lys Ala Ile Gln 
    210                 215                 220                 


Thr Asp Thr Ala Ile Asn Pro Gly Asn Ser Gly Gly Pro Leu Ile Asn 
225                 230                 235                 240 


Ile Gln Gly Gln Val Ile Gly Ile Thr Ser Ser Lys Ile Ala Thr Asn 
                245                 250                 255     


Gly Gly Thr Ser Val Glu Gly Leu Gly Phe Ala Ile Pro Ala Asn Asp 
            260                 265                 270         


Ala Ile Asn Ile Ile Glu Gln Leu Glu Lys Asn Gly Lys Val Thr Arg 
        275                 280                 285             


Pro Ala Leu Gly Ile Gln Met Val Asn Leu Ser Asn Val Ser Thr Ser 
    290                 295                 300                 


Asp Ile Arg Arg Leu Asn Ile Pro Ser Asn Val Thr Ser Gly Val Ile 
305                 310                 315                 320 


Val Arg Ser Val Gln Ser Asn Met Pro Ala Asn Gly His Leu Glu Lys 
                325                 330                 335     


Tyr Asp Val Ile Thr Lys Val Asp Asp Lys Glu Ile Ala Ser Ser Thr 
            340                 345                 350         


Asp Leu Gln Ser Ala Leu Tyr Asn His Ser Ile Gly Asp Thr Ile Lys 
        355                 360                 365             


Ile Thr Tyr Tyr Arg Asn Gly Lys Glu Glu Thr Thr Ser Ile Lys Leu 
    370                 375                 380                 


Asn Lys Ser Ser Gly Asp Leu Glu Ser 
385                 390             


<210>  21
<211>  1179
<212>  DNA
<213>  Streptococcus pneumoniae

<400>  21
atgaaacatc tgaaaacctt ttataaaaaa tggtttcagc tgctggtggt gattgtgatt     60

agctttttta gcggcgcgct gggcagcttt agcattaccc agctgaccca gaaaagcagc    120

gtgaacaaca gcaacaacaa cagcaccatt acccagaccg cgtataaaaa cgaaaacagc    180

accacccagg cggtgaacaa agtgaaagat gcggtggtga gcgtgattac ctatagcgcg    240

aaccgccaga acagcgtgtt tggcaacgat gataccgata ccgatagcca gcgcattagc    300

agcgaaggca gcggcgtgat ttataaaaaa aacgataaag aagcgtatat tgtgaccaac    360

aaccatgtga ttaacggcgc gagcaaagtg gatattcgcc tgagcgatgg caccaaagtg    420

ccgggcgaaa ttgtgggcgc ggataccttt agcgatattg cggtggtgaa aattagcagc    480

gaaaaagtga ccaccgtggc ggaatttggc gatagcagca aactgaccgt gggcgaaacc    540

gcgattgcga ttggcagccc gctgggcagc gaatatgcga acaccgtgac ccagggcatt    600

gtgagcagcc tgaaccgcaa cgtgagcctg aaaagcgaag atggccaggc gattagcacc    660

aaagcgattc agaccgatac cgcgattaac ccgggcaaca gcggcggccc gctgattaac    720

attcagggcc aggtgattgg cattaccagc agcaaaattg cgaccaacgg cggcaccagc    780

gtggaaggcc tgggctttgc gattccggcg aacgatgcga ttaacattat tgaacagctg    840

gaaaaaaacg gcaaagtgac ccgcccggcg ctgggcattc agatggtgaa cctgagcaac    900

gtgagcacca gcgatattcg ccgcctgaac attccgagca acgtgaccag cggcgtgatt    960

gtgcgcagcg tgcagagcaa catgccggcg aacggccatc tggaaaaata tgatgtgatt   1020

accaaagtgg atgataaaga aattgcgagc agcaccgatc tgcagagcgc gctgtataac   1080

catagcattg gcgataccat taaaattacc tattatcgca acggcaaaga agaaaccacc   1140

agcattaaac tgaacaaaag cagcggcgat ctggaaagc                          1179


<210>  22
<211>  246
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  22

Met Gln Arg Val Glu Phe Phe Leu Arg Gln Ile Trp Tyr Asn Ser Phe 
1               5                   10                  15      


Asn Lys Glu Glu Phe Leu Met Ile Lys Ile Leu Leu Val Glu Asp Asp 
            20                  25                  30          


Leu Gly Leu Ser Asn Ser Val Phe Asp Phe Leu Asp Asp Phe Ala Asp 
        35                  40                  45              


Val Met Gln Val Phe Asp Gly Glu Glu Gly Leu Tyr Glu Ala Glu Ser 
    50                  55                  60                  


Gly Val Tyr Asp Leu Ile Leu Leu Asp Leu Met Leu Pro Glu Lys Asn 
65                  70                  75                  80  


Gly Phe Gln Val Leu Lys Glu Leu Arg Glu Lys Gly Ile Thr Thr Pro 
                85                  90                  95      


Val Leu Ile Met Thr Ala Lys Glu Ser Leu Asp Asp Lys Gly His Gly 
            100                 105                 110         


Phe Glu Leu Gly Ala Asp Asp Tyr Leu Thr Lys Pro Phe Tyr Leu Glu 
        115                 120                 125             


Glu Leu Lys Met Arg Ile Gln Ala Leu Leu Lys Arg Ser Gly Lys Phe 
    130                 135                 140                 


Asn Glu Asn Thr Leu Thr Tyr Gly Asn Ile Val Val Asn Leu Ser Thr 
145                 150                 155                 160 


Asn Thr Val Lys Val Glu Asp Thr Pro Val Glu Leu Leu Gly Lys Glu 
                165                 170                 175     


Phe Asp Leu Leu Val Tyr Phe Leu Gln Asn Gln Asn Val Ile Leu Pro 
            180                 185                 190         


Lys Thr Gln Ile Phe Asp Arg Leu Trp Gly Phe Asp Ser Asp Thr Thr 
        195                 200                 205             


Ile Ser Val Val Glu Val Tyr Val Ser Lys Val Arg Lys Lys Leu Lys 
    210                 215                 220                 


Gly Thr Thr Phe Ala Glu Asn Leu Gln Thr Leu Arg Ser Val Gly Tyr 
225                 230                 235                 240 


Leu Leu Lys Asp Val Gln 
                245     


<210>  23
<211>  734
<212>  DNA
<213>  Streptococcus pneumoniae

<400>  23
atgcagcgcg tggaattttt tctgcgccag atttggtata acagctttaa caaagaagaa     60

tttctgatga ttaaaattct gctggtggaa gatgatctgg gcctgagcaa cagcgtgttt    120

gattttctgg atgattttgc ggatgtgatg caggtgtttg atggcgaaga aggcctgtat    180

gaagcggaaa gcggcgtgta tgatctgatt ctgctggatc tgatgctgcc ggaaaaaaac    240

gctttcaggt gctgaaagaa ctgcgcgaaa aaggcattac caccccggtg ctgattatgc    300

cgcgaaagaa agcctggatg ataaaggcca tggctttgaa ctgggcgcgg atgattatct    360

gaccaaaccg ttttatctgg aagaactgaa aatgcgcatt caggcgctgc tgaaacgcgc    420

ggcaaattta acgaaaacac cctgacctat ggcaacattg tggtgaacct gagcaccaca    480

ccgtgaaagt ggaagatacc ccggtggaac tgctgggcaa agaatttgat ctgctggtgt    540

attttctgca gaaccagaac gtgattctgc cgaaaaccca gatttttgat cgcctgtggg    600

gctttgatag cgataccacc attagcgtgg tggaagtgta tgtgagcaaa gtgcgcaaaa    660

aactgaaagg caccaccttt gcggaaaacc tgcagaccct gcgcagcgtg ggctatctgc    720

tgaaagatgt gcag                                                      734


<210>  24
<211>  444
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  24

Met Phe Ser Lys Leu Lys Lys Thr Trp Tyr Ala Asp Asp Phe Ser Tyr 
1               5                   10                  15      


Phe Ile Arg Asn Phe Gly Val Phe Thr Leu Ile Phe Ser Thr Met Thr 
            20                  25                  30          


Leu Ile Ile Leu Gln Val Met His Ser Ser Leu Tyr Thr Ser Val Asp 
        35                  40                  45              


Asp Lys Leu His Gly Leu Ser Glu Asn Pro Gln Ala Val Ile Gln Leu 
    50                  55                  60                  


Ala Ile Asn Arg Ala Thr Glu Glu Ile Lys Asp Leu Glu Asn Ala Arg 
65                  70                  75                  80  


Ala Asp Ala Ser Lys Val Glu Ile Lys Pro Asn Val Ser Ser Asn Thr 
                85                  90                  95      


Glu Val Ile Leu Phe Asp Lys Asp Phe Thr Gln Leu Leu Ser Gly Asn 
            100                 105                 110         


Arg Phe Leu Gly Leu Asp Lys Ile Lys Leu Glu Lys Lys Glu Leu Gly 
        115                 120                 125             


His Ile Tyr Gln Ile Gln Val Phe Asn Ser Tyr Gly Gln Glu Glu Ile 
    130                 135                 140                 


Tyr Arg Val Ile Leu Met Glu Thr Asn Ile Ser Ser Val Ser Thr Asn 
145                 150                 155                 160 


Ile Lys Tyr Ala Ala Val Leu Ile Asn Thr Ser Gln Leu Glu Gln Ala 
                165                 170                 175     


Ser Gln Lys His Glu Gln Leu Ile Val Val Val Met Ala Ser Phe Trp 
            180                 185                 190         


Ile Leu Ser Leu Leu Ala Ser Leu Tyr Leu Ala Arg Val Ser Val Arg 
        195                 200                 205             


Pro Leu Leu Glu Ser Met Gln Lys Gln Gln Ser Phe Val Glu Asn Ala 
    210                 215                 220                 


Ser His Glu Leu Arg Thr Pro Leu Ala Val Leu Gln Asn Arg Leu Glu 
225                 230                 235                 240 


Thr Leu Phe Arg Lys Pro Glu Ala Thr Ile Met Asp Val Ser Glu Ser 
                245                 250                 255     


Ile Ala Ser Ser Leu Glu Glu Val Arg Asn Met Arg Phe Leu Thr Thr 
            260                 265                 270         


Ser Leu Leu Asn Leu Ala Arg Arg Asp Asp Gly Ile Lys Pro Glu Leu 
        275                 280                 285             


Ala Glu Val Pro Thr Ser Phe Phe Asn Thr Thr Phe Thr Asn Tyr Glu 
    290                 295                 300                 


Met Ile Ala Ser Glu Asn Asn Arg Val Phe Arg Phe Glu Asn Arg Ile 
305                 310                 315                 320 


His Arg Thr Ile Val Thr Asp Gln Leu Leu Leu Lys Gln Leu Met Thr 
                325                 330                 335     


Ile Leu Phe Asp Asn Ala Val Lys Tyr Thr Glu Glu Asp Gly Glu Ile 
            340                 345                 350         


Asp Phe Leu Ile Ser Ala Thr Asp Arg Asn Leu Tyr Leu Leu Val Ser 
        355                 360                 365             


Asp Asn Gly Ile Gly Ile Ser Thr Glu Asp Lys Lys Lys Ile Phe Asp 
    370                 375                 380                 


Arg Phe Tyr Arg Val Asp Lys Ala Arg Thr Arg Gln Lys Gly Gly Phe 
385                 390                 395                 400 


Gly Leu Gly Leu Ser Leu Ala Lys Gln Ile Val Asp Ala Leu Lys Gly 
                405                 410                 415     


Thr Val Thr Val Lys Asp Asn Lys Pro Lys Gly Thr Ile Phe Glu Val 
            420                 425                 430         


Lys Ile Ala Ile Gln Thr Pro Ser Lys Lys Lys Lys 
        435                 440                 


<210>  25
<211>  1331
<212>  DNA
<213>  Streptococcus pneumoniae

<400>  25
atgtttagca aactgaaaaa aacctggtat gcggatgatt ttagctattt tattcgcaac     60

tttggcgtgt ttaccctgat ttttagcacc atgaccctga ttattctgca ggtgatgcat    120

agcagcctgt ataccagcgt ggatgataaa ctgcatggcc tgagcgaaaa cccgcaggcg    180

gtgattcagc tggcgattaa ccgcgcgacc gaagaaatta aagatctgga aaacgcgcgc    240

gcggatgcga gcaaagtgga aattaaaccg aacgtgagca gcaacaccga agtgattctg    300

tttgataaag attttaccca gctgctgagc ggcaaccgct ttctgggcct ggataaaatt    360

aaactggaaa aaaaagaact gggccatatt tatcagattc aggtgtttaa cagctatggc    420

caggaagaaa tttatcgcgt gattctgatg gaaaccaaca ttagcagcgt gagcaccaac    480

attaaatatg cggcggtgct gattaacacc agccagctgg aacaggcgag ccagaaacat    540

gaacagctga ttgtggtggt gatggcgagc ttttggattc tgagcctgct ggcgagcctg    600

tatctggcgc gcgtgagcgt gcgcccgctg ctggaaagca tgcagaaaca gcagagcttt    660

gtggaaaacg cgagccatga actgcgcacc ccgctggcgg tgctgcagaa ccgcctggaa    720

accctgtttc gcaaaccgga agcgaccatt atggatgtga gcgaaagcat tgcgagcagc    780

ctggaagaag tgcgcaacat gcgctttctg accaccagcc tgctgaacct ggcgcgccgc    840

gatgatggca ttaaaccgga actggcggaa gtgccgacca gcttttttaa caccaccttt    900

accaactatg aaatgattgc gagcgaaaac aaccgcgtgt ttcgctttga aaaccgcatt    960

catcgcacca ttgtgaccga tcagctgctg ctgaaacagc tgatgaccat tctgtttgat   1020

aacgcggtga aatataccga agaagatggc gaaattgatt ttctgattac gcgaccgatc   1080

gcaacctgta tctgctggtg agcgataacg gcattggcat tagcaccgaa gataaaaaaa   1140

aaatttttga tcgcttttat cgcgtggata aagcgcgcac ccgccagaaa ggcggctttg   1200

gcctgggcct gagcctggcg aaacagattg tggatgcgct gaaaggcacc gtgaccgtga   1260

aagataacaa accgaaaggc accatttttg aagtgaaaat tgcgattcag accccgagca   1320

aaaaaaaaaa a                                                        1331


