                         SEQUENCE LISTING

<110>  TOVEY, Michael
       LALLEMAND, Christophe
 
<120>  METHOD FOR CONDUCTING AN ASSAY FOR NEUTRALIZING ANTIBODIES

<130>  TOVEY9APCT

<150>  US60/983,813
<151>  2007-10-30

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  5849
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  CDS
<222>  (328)..(1980)

<400>  1
cccgggaggt accgagctct tacgcgtgct agctcgactc gggaaaggga aaccgaaact       60

gaagcccctc gggaaaggga aaccgaaact gaagcccgat ctgcatctca attagtcagc      120

aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca      180

ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc      240

ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcaaaaa      300

gcttggcatt ccggtactgt tggtaaa atg gaa gac gcc aaa aac ata aag aaa      354
                              Met Glu Asp Ala Lys Asn Ile Lys Lys         
                              1               5                           

ggc ccg gcg cca ttc tat cct cta gag gat gga acc gct gga gag caa        402
Gly Pro Ala Pro Phe Tyr Pro Leu Glu Asp Gly Thr Ala Gly Glu Gln           
10                  15                  20                  25            

ctg cat aag gct atg aag aga tac gcc ctg gtt cct gga aca att gct        450
Leu His Lys Ala Met Lys Arg Tyr Ala Leu Val Pro Gly Thr Ile Ala           
                30                  35                  40                

ttt aca gat gca cat atc gag gtg aac atc acg tac gcg gaa tac ttc        498
Phe Thr Asp Ala His Ile Glu Val Asn Ile Thr Tyr Ala Glu Tyr Phe           
            45                  50                  55                    

gaa atg tcc gtt cgg ttg gca gaa gct atg aaa cga tat ggg ctg aat        546
Glu Met Ser Val Arg Leu Ala Glu Ala Met Lys Arg Tyr Gly Leu Asn           
        60                  65                  70                        

aca aat cac aga atc gtc gta tgc agt gaa aac tct ctt caa ttc ttt        594
Thr Asn His Arg Ile Val Val Cys Ser Glu Asn Ser Leu Gln Phe Phe           
    75                  80                  85                            

atg ccg gtg ttg ggc gcg tta ttt atc gga gtt gca gtt gcg ccc gcg        642
Met Pro Val Leu Gly Ala Leu Phe Ile Gly Val Ala Val Ala Pro Ala           
90                  95                  100                 105           

aac gac att tat aat gaa cgt gaa ttg ctc aac agt atg aac att tcg        690
Asn Asp Ile Tyr Asn Glu Arg Glu Leu Leu Asn Ser Met Asn Ile Ser           
                110                 115                 120               

cag cct acc gta gtg ttt gtt tcc aaa aag ggg ttg caa aaa att ttg        738
Gln Pro Thr Val Val Phe Val Ser Lys Lys Gly Leu Gln Lys Ile Leu           
            125                 130                 135                   

aac gtg caa aaa aaa tta cca ata atc cag aaa att att atc atg gat        786
Asn Val Gln Lys Lys Leu Pro Ile Ile Gln Lys Ile Ile Ile Met Asp           
        140                 145                 150                       

tct aaa acg gat tac cag gga ttt cag tcg atg tac acg ttc gtc aca        834
Ser Lys Thr Asp Tyr Gln Gly Phe Gln Ser Met Tyr Thr Phe Val Thr           
    155                 160                 165                           

tct cat cta cct ccc ggt ttt aat gaa tac gat ttt gta cca gag tcc        882
Ser His Leu Pro Pro Gly Phe Asn Glu Tyr Asp Phe Val Pro Glu Ser           
170                 175                 180                 185           

ttt gat cgt gac aaa aca att gca ctg ata atg aat tcc tct gga tct        930
Phe Asp Arg Asp Lys Thr Ile Ala Leu Ile Met Asn Ser Ser Gly Ser           
                190                 195                 200               

act ggg tta cct aag ggt gtg gcc ctt ccg cat aga act gcc tgc gtc        978
Thr Gly Leu Pro Lys Gly Val Ala Leu Pro His Arg Thr Ala Cys Val           
            205                 210                 215                   

aga ttc tcg cat gcc aga gat cct att ttt ggc aat caa atc att ccg       1026
Arg Phe Ser His Ala Arg Asp Pro Ile Phe Gly Asn Gln Ile Ile Pro           
        220                 225                 230                       

gat act gcg att tta agt gtt gtt cca ttc cat cac ggt ttt gga atg       1074
Asp Thr Ala Ile Leu Ser Val Val Pro Phe His His Gly Phe Gly Met           
    235                 240                 245                           

ttt act aca ctc gga tat ttg ata tgt gga ttt cga gtc gtc tta atg       1122
Phe Thr Thr Leu Gly Tyr Leu Ile Cys Gly Phe Arg Val Val Leu Met           
250                 255                 260                 265           

tat aga ttt gaa gaa gag ctg ttt tta cga tcc ctt cag gat tac aaa       1170
Tyr Arg Phe Glu Glu Glu Leu Phe Leu Arg Ser Leu Gln Asp Tyr Lys           
                270                 275                 280               

att caa agt gcg ttg cta gta cca acc cta ttt tca ttc ttc gcc aaa       1218
Ile Gln Ser Ala Leu Leu Val Pro Thr Leu Phe Ser Phe Phe Ala Lys           
            285                 290                 295                   

agc act ctg att gac aaa tac gat tta tct aat tta cac gaa att gct       1266
Ser Thr Leu Ile Asp Lys Tyr Asp Leu Ser Asn Leu His Glu Ile Ala           
        300                 305                 310                       

tct ggg ggc gca cct ctt tcg aaa gaa gtc ggg gaa gcg gtt gca aaa       1314
Ser Gly Gly Ala Pro Leu Ser Lys Glu Val Gly Glu Ala Val Ala Lys           
    315                 320                 325                           

cgc ttc cat ctt cca ggg ata cga caa gga tat ggg ctc act gag act       1362
Arg Phe His Leu Pro Gly Ile Arg Gln Gly Tyr Gly Leu Thr Glu Thr           
330                 335                 340                 345           

aca tca gct att ctg att aca ccc gag ggg gat gat aaa ccg ggc gcg       1410
Thr Ser Ala Ile Leu Ile Thr Pro Glu Gly Asp Asp Lys Pro Gly Ala           
                350                 355                 360               

gtc ggt aaa gtt gtt cca ttt ttt gaa gcg aag gtt gtg gat ctg gat       1458
Val Gly Lys Val Val Pro Phe Phe Glu Ala Lys Val Val Asp Leu Asp           
            365                 370                 375                   

acc ggg aaa acg ctg ggc gtt aat cag aga ggc gaa tta tgt gtc aga       1506
Thr Gly Lys Thr Leu Gly Val Asn Gln Arg Gly Glu Leu Cys Val Arg           
        380                 385                 390                       

gga cct atg att atg tcc ggt tat gta aac aat ccg gaa gcg acc aac       1554
Gly Pro Met Ile Met Ser Gly Tyr Val Asn Asn Pro Glu Ala Thr Asn           
    395                 400                 405                           

gcc ttg att gac aag gat gga tgg cta cat tct gga gac ata gct tac       1602
Ala Leu Ile Asp Lys Asp Gly Trp Leu His Ser Gly Asp Ile Ala Tyr           
410                 415                 420                 425           

tgg gac gaa gac gaa cac ttc ttc ata gtt gac cgc ttg aag tct tta       1650
Trp Asp Glu Asp Glu His Phe Phe Ile Val Asp Arg Leu Lys Ser Leu           
                430                 435                 440               

att aaa tac aaa gga tat cag gtg gcc ccc gct gaa ttg gaa tcg ata       1698
Ile Lys Tyr Lys Gly Tyr Gln Val Ala Pro Ala Glu Leu Glu Ser Ile           
            445                 450                 455                   

ttg tta caa cac ccc aac atc ttc gac gcg ggc gtg gca ggt ctt ccc       1746
Leu Leu Gln His Pro Asn Ile Phe Asp Ala Gly Val Ala Gly Leu Pro           
        460                 465                 470                       

gac gat gac gcc ggt gaa ctt ccc gcc gcc gtt gtt gtt ttg gag cac       1794
Asp Asp Asp Ala Gly Glu Leu Pro Ala Ala Val Val Val Leu Glu His           
    475                 480                 485                           

gga aag acg atg acg gaa aaa gag atc gtg gat tac gtg gcc agt caa       1842
Gly Lys Thr Met Thr Glu Lys Glu Ile Val Asp Tyr Val Ala Ser Gln           
490                 495                 500                 505           

gta aca acc gcg aaa aag ttg cgc gga gga gtt gtg ttt gtg gac gaa       1890
Val Thr Thr Ala Lys Lys Leu Arg Gly Gly Val Val Phe Val Asp Glu           
                510                 515                 520               

gta ccg aaa ggt ctt acc gga aaa ctc gac gca aga aaa atc aga gag       1938
Val Pro Lys Gly Leu Thr Gly Lys Leu Asp Ala Arg Lys Ile Arg Glu           
            525                 530                 535                   

atc ctc ata aag gcc aag aag ggc gga aag tcc aaa ttg taa               1980
Ile Leu Ile Lys Ala Lys Lys Gly Gly Lys Ser Lys Leu                       
        540                 545                 550                       

aatgtaactg tattcagcga tgacgaaatt cttagctatt gtaatactgc gatgagtggc     2040

agggcggggc gtaatttttt taaggcagtt attggtgccc ttaaacgcct ggtgctacgc     2100

ctgaataagt gataataagc ggatgaatgg cagaaattcg ccggatcttt gtgaaggaac     2160

cttacttctg tggtgtgaca taattggaca aactacctac agagatttaa agctctaagg     2220

taaatataaa atttttaagt gtataatgtg ttaaactact gattctaatt gtttgtgtat     2280

tttagattcc aacctatgga actgatgaat gggagcagtg gtggaatgcc tttaatgagg     2340

aaaacctgtt ttgctcagaa gaaatgccat ctagtgatga tgaggctact gctgactctc     2400

aacattctac tcctccaaaa aagaagagaa aggtagaaga ccccaaggac tttccttcag     2460

aattgctaag ttttttgagt catgctgtgt ttagtaatag aactcttgct tgctttgcta     2520

tttacaccac aaaggaaaaa gctgcactgc tatacaagaa aattatggaa aaatattctg     2580

taacctttat aagtaggcat aacagttata atcataacat actgtttttt cttactccac     2640

acaggcatag agtgtctgct attaataact atgctcaaaa attgtgtacc tttagctttt     2700

taatttgtaa aggggttaat aaggaatatt tgatgtatag tgccttgact agagatcata     2760

atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc     2820

ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat     2880

aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg     2940

cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatccgtcga     3000

ccgatgccct tgagagcctt caacccagtc agctccttcc ggtgggcgcg gggcatgact     3060

atcgtcgccg cacttatgac tgtcttcttt atcatgcaac tcgtaggaca ggtgccggca     3120

gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc     3180

ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg     3240

aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct     3300

ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca     3360

gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct     3420

cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc     3480

gggaagcgtg gcgctttctc aatgctcacg ctgtaggtat ctcagttcgg tgtaggtcgt     3540

tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc     3600

cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc     3660

cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg     3720

gtggcctaac tacggctaca ctagaaggac agtatttggt atctgcgctc tgctgaagcc     3780

agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag     3840

cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga     3900

tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat     3960

tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag     4020

ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat     4080

cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc     4140

cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat     4200

accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag     4260

ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg     4320

ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc     4380

tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca     4440

acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg     4500

tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc     4560

actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta     4620

ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc     4680

aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg     4740

ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc     4800

cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc     4860

aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat     4920

actcatactc ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag     4980

cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc     5040

ccgaaaagtg ccacctgacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt     5100

tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt     5160

cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc gggggctccc     5220

tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg attagggtga     5280

tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga cgttggagtc     5340

cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc ctatctcggt     5400

ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa aaaatgagct     5460

gatttaacaa aaatttaacg cgaattttaa caaaatatta acgtttacaa tttcccattc     5520

gccattcagg ctgcgcaact gttgggaagg gcgatcggtg cgggcctctt cgctattacg     5580

ccagcccaag ctaccatgat aagtaagtaa tattaaggta cgtggaggtt ttacttgctt     5640

taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg     5700

ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca     5760

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat     5820

cttatggtac tgtaactgag ctaacataa                                       5849


<210>  2
<211>  550
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  2

Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asn Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Asn Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ser Lys Leu 
545                 550 


<210>  3
<211>  4412
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  CDS
<222>  (358)..(1077)

<400>  3
tagttattac tagcgctacc ggactcagac tcgggaaagg gaaaccgaaa ctgaagcccc       60

tcgggaaagg gaaaccgaaa ctgaagcccg atctgcatct caattagtca gcaaccatag      120

tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc cattctccgc      180

cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg gcctctgagc      240

tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa tctcgagctc      300

aagcttcgaa ttctgcagtc gacggtaccg cgggcccggg atccaccggt cgccacc         357

atg gtg agc aag ggc gag gag ctg ttc acc ggg gtg gtg ccc atc ctg        405
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu           
1               5                   10                  15                

gtc gag ctg gac ggc gac gta aac ggc cac aag ttc agc gtg tcc ggc        453
Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly           
            20                  25                  30                    

gag ggc gag ggc gat gcc acc tac ggc aag ctg acc ctg aag ttc atc        501
Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile           
        35                  40                  45                        

tgc acc acc ggc aag ctg ccc gtg ccc tgg ccc acc ctc gtg acc acc        549
Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr           
    50                  55                  60                            

ctg acc tac ggc gtg cag tgc ttc agc cgc tac ccc gac cac atg aag        597
Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys           
65                  70                  75                  80            

cag cac gac ttc ttc aag tcc gcc atg ccc gaa ggc tac gtc cag gag        645
Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu           
                85                  90                  95                

cgc acc atc ttc ttc aag gac gac ggc aac tac aag acc cgc gcc gag        693
Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu           
            100                 105                 110                   

gtg aag ttc gag ggc gac acc ctg gtg aac cgc atc gag ctg aag ggc        741
Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly           
        115                 120                 125                       

atc gac ttc aag gag gac ggc aac atc ctg ggg cac aag ctg gag tac        789
Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr           
    130                 135                 140                           

aac tac aac agc cac aac gtc tat atc atg gcc gac aag cag aag aac        837
Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn           
145                 150                 155                 160           

ggc atc aag gtg aac ttc aag atc cgc cac aac atc gag gac ggc agc        885
Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser           
                165                 170                 175               

gtg cag ctc gcc gac cac tac cag cag aac acc ccc atc ggc gac ggc        933
Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly           
            180                 185                 190                   

ccc gtg ctg ctg ccc gac aac cac tac ctg agc acc cag tcc gcc ctg        981
Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu           
        195                 200                 205                       

agc aaa gac ccc aac gag aag cgc gat cac atg gtc ctg ctg gag ttc       1029
Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe           
    210                 215                 220                           

gtg acc gcc gcc ggg atc act ctc ggc atg gac gag ctg tac aag taa       1077
Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys               
225                 230                 235                               

agcggccgcg actctagatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt     1137

taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg     1197

ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca     1257

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat     1317

cttaaggcgt aaattgtaag cgttaatatt ttgttaaaat tcgcgttaaa tttttgttaa     1377

atcagctcat tttttaacca ataggccgaa atcggcaaaa tcccttataa atcaaaagaa     1437

tagaccgaga tagggttgag tgttgttcca gtttggaaca agagtccact attaaagaac     1497

gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg gcgatggccc actacgtgaa     1557

ccatcaccct aatcaagttt tttggggtcg aggtgccgta aagcactaaa tcggaaccct     1617

aaagggagcc cccgatttag agcttgacgg ggaaagccgg cgaacgtggc gagaaaggaa     1677

gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa gtgtagcggt cacgctgcgc     1737

gtaaccacca cacccgccgc gcttaatgcg ccgctacagg gcgcgtcagg tggcactttt     1797

cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat     1857

ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtcct     1917

gaggcggaaa gaaccagctg tggaatgtgt gtcagttagg gtgtggaaag tccccaggct     1977

ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc aggtgtggaa     2037

agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa     2097

ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt     2157

ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc gcctcggcct     2217

ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaagatc     2277

gatcaagaga caggatgagg atcgtttcgc atgattgaac aagatggatt gcacgcaggt     2337

tctccggccg cttgggtgga gaggctattc ggctatgact gggcacaaca gacaatcggc     2397

tgctctgatg ccgccgtgtt ccggctgtca gcgcaggggc gcccggttct ttttgtcaag     2457

accgacctgt ccggtgccct gaatgaactg caagacgagg cagcgcggct atcgtggctg     2517

gccacgacgg gcgttccttg cgcagctgtg ctcgacgttg tcactgaagc gggaagggac     2577

tggctgctat tgggcgaagt gccggggcag gatctcctgt catctcacct tgctcctgcc     2637

gagaaagtat ccatcatggc tgatgcaatg cggcggctgc atacgcttga tccggctacc     2697

tgcccattcg accaccaagc gaaacatcgc atcgagcgag cacgtactcg gatggaagcc     2757

ggtcttgtcg atcaggatga tctggacgaa gagcatcagg ggctcgcgcc agccgaactg     2817

ttcgccaggc tcaaggcgag catgcccgac ggcgaggatc tcgtcgtgac ccatggcgat     2877

gcctgcttgc cgaatatcat ggtggaaaat ggccgctttt ctggattcat cgactgtggc     2937

cggctgggtg tggcggaccg ctatcaggac atagcgttgg ctacccgtga tattgctgaa     2997

gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt acggtatcgc cgctcccgat     3057

tcgcagcgca tcgccttcta tcgccttctt gacgagttct tctgagcggg actctggggt     3117

tcgaaatgac cgaccaagcg acgcccaacc tgccatcacg agatttcgat tccaccgccg     3177

ccttctatga aaggttgggc ttcggaatcg ttttccggga cgccggctgg atgatcctcc     3237

agcgcgggga tctcatgctg gagttcttcg cccaccctag ggggaggcta actgaaacac     3297

ggaaggagac aataccggaa ggaacccgcg ctatgacggc aataaaaaga cagaataaaa     3357

cgcacggtgt tgggtcgttt gttcataaac gcggggttcg gtcccagggc tggcactctg     3417

tcgatacccc accgagaccc cattggggcc aatacgcccg cgtttcttcc ttttccccac     3477

cccacccccc aagttcgggt gaaggcccag ggctcgcagc caacgtcggg gcggcaggcc     3537

ctgccatagc ctcaggttac tcatatatac tttagattga tttaaaactt catttttaat     3597

ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg     3657

agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc     3717

ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg     3777

tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag     3837

cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact     3897

ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg     3957

gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc     4017

ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg     4077

aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg     4137

cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag     4197

ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc     4257

gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct     4317

ttttacggtt cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc     4377

ctgattctgt ggataaccgt attaccgcca tgcat                                4412


<210>  4
<211>  239
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  4

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  5
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  5
ctcgggaaag ggaaaccgaa actgaagccc ctcgggaaag ggaaaccgaa actgaagccc       60


<210>  6
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  6
ggraaagwga aactg                                                        15


<210>  7
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n is either a, c, g, or t.

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is either a, c, g, or t.

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is either a, c, g, or t.

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is either a, c, g, or t.

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is either a, c, g, or t.

<400>  7
nnnsanttcc gggaantgns n                                                 21


<210>  8
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  8
ctcgggaaag ggaaaccgaa actgaagcc                                         29


