SEQUENCE LISTING

<110> ZymoGenetics, Inc.
       Levin, Steven D.
      Ramsdell, Frederick J.
      Howard, Edward D.
      Taft, David W.
      Rixon, Mark W.
      Hebb, LuAnne
      

<120> COMPOSITIONS AND METHODS FOR MODULATING
  IMMUNE RESPONSES

<130> 07-27PC

<160> 7

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 726
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS            
<222> (1)...(726)

<400> 1
atg gct gtg ttt ctg cag ctg cta ccg ctg ctg ctc tcg agg gcc caa   48
Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln
 1               5                   10                  15
 
ggg aac cct ggg gct tct ctg gac ggc cgc cct ggg gac cgg gtg aat   96
Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn
             20                  25                  30
 
ctc tcc tgc gga gga gtc tct cat ccc atc cgc tgg gtc tgg gca ccc   144
Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro
         35                  40                  45
 
agc ttc ccg gcc tgc aag ggc ctg tcc aaa gga cgc cga ccg atc ctg   192
Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu
     50                  55                  60
 
tgg gcc tct tcg agc ggg acc ccc acc gtg cct ccc ctc cag cct ttc   240
Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe
 65                  70                  75                  80
 
gtc ggc cgc cta cgc tcc ctg gac tct ggt atc cgg cgg ctg gag ctc   288
Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu
                 85                  90                  95
 
ctc ttg agc gcg ggg gac tcg ggc act ttt ttc tgc aag ggc cgc cac   336
Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His
            100                 105                 110
 
gag gac gag agc cgt aca gtg ctt cac gtg ctg ggg gac agg acc tat   384
Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr
        115                 120                 125
 
tgc aag gcc ccc ggg cct acc cat ggg tcc gtg tat ccc cag ctc ctg   432
Cys Lys Ala Pro Gly Pro Thr His Gly Ser Val Tyr Pro Gln Leu Leu
    130                 135                 140
 
atc ccg ctg ctg ggc gct ggg ttg gtg ctc gga ctg gga gct ttg ggc   480
Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly
145                 150                 155                 160
 
ctg gtc tgg tgg ctg cac agg cgc ctg ccc ccg caa ccg att cga cca   528
Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro
                165                 170                 175
 
ctc cct aga ttt gct cca ctt gtg aaa acc gag ccc cag agg cca gta   576
Leu Pro Arg Phe Ala Pro Leu Val Lys Thr Glu Pro Gln Arg Pro Val
            180                 185                 190
 
aag gag gaa gag ccc aag att cca ggg gac ctg gac cag gaa ccg agc   624
Lys Glu Glu Glu Pro Lys Ile Pro Gly Asp Leu Asp Gln Glu Pro Ser
        195                 200                 205
 
ctg ctc tat gcg gat ctg gac cat cta gcc ctc agc agg ccc cgc cgg   672
Leu Leu Tyr Ala Asp Leu Asp His Leu Ala Leu Ser Arg Pro Arg Arg
    210                 215                 220
 
ctg tcc aca gcg gac cct gct gat gcc tcc acc atc tat gca gtt gta   720
Leu Ser Thr Ala Asp Pro Ala Asp Ala Ser Thr Ile Tyr Ala Val Val
225                 230                 235                 240
 
gtt tga                                                           726
Val  *

 

<210> 2
<211> 241
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln
 1               5                  10                  15      
Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn
            20                  25                  30          
Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro
        35                  40                  45              
Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu
    50                  55                  60                  
Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe
65                  70                  75                  80  
Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu
                85                  90                  95      
Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His
            100                 105                 110         
Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr
        115                 120                 125             
Cys Lys Ala Pro Gly Pro Thr His Gly Ser Val Tyr Pro Gln Leu Leu
    130                 135                 140                 
Ile Pro Leu Leu Gly Ala Gly Leu Val Leu Gly Leu Gly Ala Leu Gly
145                 150                 155                 160 
Leu Val Trp Trp Leu His Arg Arg Leu Pro Pro Gln Pro Ile Arg Pro
                165                 170                 175     
Leu Pro Arg Phe Ala Pro Leu Val Lys Thr Glu Pro Gln Arg Pro Val
            180                 185                 190         
Lys Glu Glu Glu Pro Lys Ile Pro Gly Asp Leu Asp Gln Glu Pro Ser
        195                 200                 205             
Leu Leu Tyr Ala Asp Leu Asp His Leu Ala Leu Ser Arg Pro Arg Arg
    210                 215                 220                 
Leu Ser Thr Ala Asp Pro Ala Asp Ala Ser Thr Ile Tyr Ala Val Val
225                 230                 235                 240 
Val
    


<210> 3
<211> 142
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln
 1               5                  10                  15      
Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn
            20                  25                  30          
Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro
        35                  40                  45              
Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu
    50                  55                  60                  
Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe
65                  70                  75                  80  
Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu
                85                  90                  95      
Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His
            100                 105                 110         
Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr
        115                 120                 125             
Cys Lys Ala Pro Gly Pro Thr His Gly Ser Val Tyr Pro Gln
    130                 135                 140         


<210> 4
<211> 699
<212> DNA
<213> Mus musculus

<220> 
<221> CDS            
<222> (1)...(699)

<400> 4
atg gcc ttg gtc ctg ccg ctg ctg cct ttg ttg ctc tca aag gtc cag   48
Met Ala Leu Val Leu Pro Leu Leu Pro Leu Leu Leu Ser Lys Val Gln
 1               5                   10                  15
 
ggg aat ccc gag gtt tct ttg gag ggc agc cct ggg gac cgg gtg aat   96
Gly Asn Pro Glu Val Ser Leu Glu Gly Ser Pro Gly Asp Arg Val Asn
             20                  25                  30
 
ctc tcc tgc ata ggg gtc tcc gac ccc acc cgc tgg gct tgg gcg cct   144
Leu Ser Cys Ile Gly Val Ser Asp Pro Thr Arg Trp Ala Trp Ala Pro
         35                  40                  45
 
agt ttc cca gca tgc aag ggc ttg tct aaa ggg cgc cgt ccg atc ttg   192
Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu
     50                  55                  60
 
tgg gcc tcg acg aga ggg acc cca act gtg ctc cag cat ttc tct ggc   240
Trp Ala Ser Thr Arg Gly Thr Pro Thr Val Leu Gln His Phe Ser Gly
 65                  70                  75                  80
 
cgc ctg cgt tcc ctg gac aat ggt atc aag cgg cta gag ctg ctg ctg   288
Arg Leu Arg Ser Leu Asp Asn Gly Ile Lys Arg Leu Glu Leu Leu Leu
                 85                  90                  95
 
agc gcc ggg gat tct gga acc ttt ttc tgc aaa gga cgc cac gag aat   336
Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His Glu Asn
            100                 105                 110
 
gag agt cgc aca gtg ctt caa gtg tta ggg gac aag gca ggt tgc cgg   384
Glu Ser Arg Thr Val Leu Gln Val Leu Gly Asp Lys Ala Gly Cys Arg
        115                 120                 125
 
cct gca gga tct acc cac ggg tac gag tat ccc aag gtc ctg att ccg   432
Pro Ala Gly Ser Thr His Gly Tyr Glu Tyr Pro Lys Val Leu Ile Pro
    130                 135                 140
 
ctc ctg ggc gtt ggg ctt gtg ctg gga ctg gga gtc gcg ggc gtg gtc   480
Leu Leu Gly Val Gly Leu Val Leu Gly Leu Gly Val Ala Gly Val Val
145                 150                 155                 160
 
tgg cgg cgg cgc agt tct gtc cct ccc tcc cac ata gct cca gtc ata   528
Trp Arg Arg Arg Ser Ser Val Pro Pro Ser His Ile Ala Pro Val Ile
                165                 170                 175
 
aat gct gag cca cag agg cct tta gaa cag gag tcc aag atc tca ggc   576
Asn Ala Glu Pro Gln Arg Pro Leu Glu Gln Glu Ser Lys Ile Ser Gly
            180                 185                 190
 
cac ctg gac cag gag ccg agc ctg cac tac gct gat ctg gac cac tct   624
His Leu Asp Gln Glu Pro Ser Leu His Tyr Ala Asp Leu Asp His Ser
        195                 200                 205
 
gtc ctc ggg agg cac cgc cgg atg tcc aca gtg gtt tct ggt gat gcc   672
Val Leu Gly Arg His Arg Arg Met Ser Thr Val Val Ser Gly Asp Ala
    210                 215                 220
 
tcc act gtc tat gcg gtt gta gta taa                               699
Ser Thr Val Tyr Ala Val Val Val  *
225                 230
 

<210> 5
<211> 232
<212> PRT
<213> Mus musculus

<400> 5
Met Ala Leu Val Leu Pro Leu Leu Pro Leu Leu Leu Ser Lys Val Gln
 1               5                  10                  15      
Gly Asn Pro Glu Val Ser Leu Glu Gly Ser Pro Gly Asp Arg Val Asn
            20                  25                  30          
Leu Ser Cys Ile Gly Val Ser Asp Pro Thr Arg Trp Ala Trp Ala Pro
        35                  40                  45              
Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu
    50                  55                  60                  
Trp Ala Ser Thr Arg Gly Thr Pro Thr Val Leu Gln His Phe Ser Gly
65                  70                  75                  80  
Arg Leu Arg Ser Leu Asp Asn Gly Ile Lys Arg Leu Glu Leu Leu Leu
                85                  90                  95      
Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His Glu Asn
            100                 105                 110         
Glu Ser Arg Thr Val Leu Gln Val Leu Gly Asp Lys Ala Gly Cys Arg
        115                 120                 125             
Pro Ala Gly Ser Thr His Gly Tyr Glu Tyr Pro Lys Val Leu Ile Pro
    130                 135                 140                 
Leu Leu Gly Val Gly Leu Val Leu Gly Leu Gly Val Ala Gly Val Val
145                 150                 155                 160 
Trp Arg Arg Arg Ser Ser Val Pro Pro Ser His Ile Ala Pro Val Ile
                165                 170                 175     
Asn Ala Glu Pro Gln Arg Pro Leu Glu Gln Glu Ser Lys Ile Ser Gly
            180                 185                 190         
His Leu Asp Gln Glu Pro Ser Leu His Tyr Ala Asp Leu Asp His Ser
        195                 200                 205             
Val Leu Gly Arg His Arg Arg Met Ser Thr Val Val Ser Gly Asp Ala
    210                 215                 220                 
Ser Thr Val Tyr Ala Val Val Val
225                 230         


<210> 6
<211> 140
<212> PRT
<213> Mus musculus

<400> 6
Met Ala Leu Val Leu Pro Leu Leu Pro Leu Leu Leu Ser Lys Val Gln
 1               5                  10                  15      
Gly Asn Pro Glu Val Ser Leu Glu Gly Ser Pro Gly Asp Arg Val Asn
            20                  25                  30          
Leu Ser Cys Ile Gly Val Ser Asp Pro Thr Arg Trp Ala Trp Ala Pro
        35                  40                  45              
Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu
    50                  55                  60                  
Trp Ala Ser Thr Arg Gly Thr Pro Thr Val Leu Gln His Phe Ser Gly
65                  70                  75                  80  
Arg Leu Arg Ser Leu Asp Asn Gly Ile Lys Arg Leu Glu Leu Leu Leu
                85                  90                  95      
Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His Glu Asn
            100                 105                 110         
Glu Ser Arg Thr Val Leu Gln Val Leu Gly Asp Lys Ala Gly Cys Arg
        115                 120                 125             
Pro Ala Gly Ser Thr His Gly Tyr Glu Tyr Pro Lys
    130                 135                 140 


<210> 7
<211> 138
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Val Phe Leu Gln Leu Leu Pro Leu Leu Leu Ser Arg Ala Gln
 1               5                  10                  15      
Gly Asn Pro Gly Ala Ser Leu Asp Gly Arg Pro Gly Asp Arg Val Asn
            20                  25                  30          
Leu Ser Cys Gly Gly Val Ser His Pro Ile Arg Trp Val Trp Ala Pro
        35                  40                  45              
Ser Phe Pro Ala Cys Lys Gly Leu Ser Lys Gly Arg Arg Pro Ile Leu
    50                  55                  60                  
Trp Ala Ser Ser Ser Gly Thr Pro Thr Val Pro Pro Leu Gln Pro Phe
65                  70                  75                  80  
Val Gly Arg Leu Arg Ser Leu Asp Ser Gly Ile Arg Arg Leu Glu Leu
                85                  90                  95      
Leu Leu Ser Ala Gly Asp Ser Gly Thr Phe Phe Cys Lys Gly Arg His
            100                 105                 110         
Glu Asp Glu Ser Arg Thr Val Leu His Val Leu Gly Asp Arg Thr Tyr
        115                 120                 125             
Cys Lys Ala Pro Gly Pro Thr His Gly Ser
    130                 135             
 

