                         SEQUENCE LISTING

<110>  DiMarchi, et al.
 
<120>  Glucagon Antagonists

<130>  29920-79399 (31135/43853)

<150>  60/983783
<151>  2000-01-01

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  2
<211>  28
<212>  PRT
<213>  Artificial Sequence                   

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<400>  2

Ser Gln Gly Thr Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg 
1               5                   10                  15      


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25              


<210>  3
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<400>  3

Gln Gly Thr Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg 
1               5                   10                  15      


Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25          


<210>  4
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<400>  4

Gly Thr Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala 
1               5                   10                  15      


Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25      


<210>  5
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<400>  5

Thr Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln 
1               5                   10                  15      


Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25  


<210>  6
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is glutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is Met, Leu or Nle

<400>  6

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  7
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  7

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  8
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  8

Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  9
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  9

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  10
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  10

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Xaa 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  11
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypetide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  11

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  


<210>  12
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  12

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  


<210>  13
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  13

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Cys Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  14
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  14

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Xaa Asn Thr 
            20                  


<210>  15
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  15

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Cys 
            20                  


<210>  16
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  16

Phe Thr Ser Xaa Tyr Ser Arg Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Lys Trp Leu Xaa Asn Thr 
            20                  


<210>  17
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  17

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Cys Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Xaa Asn Thr 
            20                  


<210>  18
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  18

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Glu Cys Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4

<400>  19

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 8 amino acids 
       of oxyntomodulin

<400>  20

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  21
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy 4 amino acids of 
       oxyntomodulin carboxy terminus

<400>  21

Lys Arg Asn Arg 
1               


<210>  22
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Lys, Cys, Orn, homocycstein or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocycstein or acetyl phenyalanine

<400>  22

Phe Thr Ser Arg Tyr Ser Xaa Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Met Asn Thr 
            20                  


<210>  23
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  23

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Xaa 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  24
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  24

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr Lys Arg Asn Arg Asn Asn Ile Ala 
            20                  25                  30          


<210>  25
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  25

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  26
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Pegylation

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  26

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Xaa 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn Arg Asn Asn Ile Ala 
            20                  25                  30          


<210>  27
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  27

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Xaa 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn Arg 
            20                  25              


<210>  28
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  28

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr Lys Arg Asn Arg 
            20                  25              


<210>  29
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  29

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  30
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  30

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn Arg Asn Asn Ile Ala 
            20                  25                  30          


<210>  31
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  31

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Cys 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn Arg 
            20                  25              


<210>  32
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  32

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  33
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  33

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  34
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  2-butyrolactone bound through thiol group of Cysteine

<400>  34

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  35
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analogue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Carboxymethyl group bound through thiol group of Cysteine

<400>  35

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  36
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  36

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Glu Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  37
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  37

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  38
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  38

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  39
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Asp, Glu, cysteic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa id Thr, Asp, Glu, cysteic acid or homocysteic acid

<400>  39

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  40
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Glu, cysteic acid, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  40

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  41
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Glu, cysteic acid, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr, glu or Asp

<400>  41

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  42
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Glu, cysteic acid, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  42

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  43
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  20kDa PEG group attached to Xaa at position 11

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  43

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Cys Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  44
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  20kDa PEG group attached to Xaa at position 16

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  44

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Cys 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  45
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  45

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Xaa Xaa Xaa 
            20                  


<210>  46
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Lys, Cys, Orn, homocycstein or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Pegylated

<400>  46

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa Xaa Gly Pro Ser Ser Gly Ala Pro 
            20                  25                  30          


Pro Pro Ser 
        35  


<210>  47
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Pegylated

<400>  47

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Xaa 
        35  


<210>  48
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  48

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  49
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met , Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Pegylated

<400>  49

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Xaa 
        35  


<210>  50
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<400>  50

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  51
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  51

Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp 
1               5                   10                  15      


Leu Met Asn Thr 
            20  


<210>  52
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Homocysteic acid

<400>  52

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  53
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<400>  53

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Xaa 
1               5                   10      


<210>  54
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenyl lactic acid

<400>  54

His Ser Gln Gly Thr Xaa 
1               5       


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<400>  55

Ser Gln Gly Thr Xaa 
1               5   


<210>  56
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is phenyl lactic acid

<400>  56

Gln Gly Thr Xaa 
1               


<210>  57
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is phenyl lactic acid

<400>  57

Gly Thr Xaa 
1           


<210>  58
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is phenyl lactic acid

<400>  58

Thr Xaa 
1       


<210>  59
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of His, D-histidine, 
       alpha, alpha-dimethyl imidiazole acetic acid (DMIA), N-methyl 
       histidine, alpha-methyl histidine, imidazole acetic acid, 
       desaminohistidine, hydroxyl-histidine, acetyl-histidine and 
       

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, Val, Gly, N-methyl serine, N-methyl alanine, and 
       aminoisobutyric acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is selected from a group consisting of Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenyl lactic acid

<400>  59

Xaa Xaa Xaa Gly Thr Xaa 
1               5       


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, Val, Gly, N-methyl serine, N-methyl alanine, and 
       aminoisobutyric acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<400>  60

Xaa Xaa Gly Thr Xaa 
1               5   


<210>  61
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Glu and Gln

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is phenyl lactic acid

<400>  61

Xaa Gly Thr Xaa 
1               


<210>  62
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AL

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate optionally replaced with amide

<400>  62

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  63
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AM

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate optionally replaced with amide

<400>  63

Ser Gln Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg 
1               5                   10                  15      


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25              


<210>  64
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AN

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Threonine in position 4 and phenyl lactic acid in position 5 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Optional C-terminal alpha carboxylate replaced with amide

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate optionally replaced with amide

<400>  64

Ser Gln Gly Thr Xaa Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg 
1               5                   10                  15      


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25              


<210>  65
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AO

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Threonine in position 5 and phenyl lactic acid in position 6 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal alpha carboxylate optionally replaced with amide

<400>  65

His Ser Gln Gly Thr Xaa Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  66
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AQ

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is amino isobutyric acid

<400>  66

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  67
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide AT

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<400>  67

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  68
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of His, D-histidine, 
       alpha, alpha-dimethyl imidiazole acetic acid (DMIA), N-methyl 
       histidine, alpha-methyl histidine, imidazole acetic acid, 
       desaminohistidine, hydroxyl-histidine, acetyl-histidine and 
       

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, Val, Gly, N-methyl serine, N-methyl alanine, and 
       aminoisobutyric acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is selected from a group consisting of Glu or Gln

<400>  68

Xaa Xaa Xaa Thr Gly Phe 
1               5       


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, Val, Gly, N-methyl serine, N-methyl alanine, and 
       aminoisobutyric acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Glu or Gln

<400>  69

Xaa Xaa Thr Gly Phe 
1               5   


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Glu or Gln

<400>  70

Xaa Thr Gly Phe 
1               


<210>  71
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate optionally replaced with an amide

<400>  71

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


