                         SEQUENCE LISTING

<110>  Affinergy, Inc.
       Darby, Martyn
       Sanford, Isaac
       Benson, R. Edward
       Gron, Hanne
       Hamilton, Paul
       Nair, Shrikumar
 
<120>  Methods and compositions for delivery of glycopeptide antibiotics
        to medical device surfaces

<130>  AF-031-US-PCT

<160>  131   

<170>  PatentIn version 3.4

<210>  1
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  1

Cys Leu Ile Asp Met Tyr Gly Val Cys His Asn Phe Asp Gly Ala Tyr 
1               5                   10                  15      


Asp Ser 
        


<210>  2
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  2

Cys Leu Phe Asp Ile Phe Gly Val Cys His Ser Phe Asp Gly Ala Tyr 
1               5                   10                  15      


Asp Ser 
        


<210>  3
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  3

Pro Cys Glu Leu Ile Asp Met Phe Gly Asn Asp His Cys Pro 
1               5                   10                  


<210>  4
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  4

Ser Cys Asp Met Leu Phe Cys Glu Asn Phe Ser Gly Ser Gly Asn Asn 
1               5                   10                  15      


Trp Phe Ser 
            


<210>  5
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  5

Ser Leu Ile Asp Met Tyr Gly Val Cys His Asn Phe Asp Gly Ala Tyr 
1               5                   10                  15      


Asp Ser 
        


<210>  6
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized


<220>
<221>  DISULFID
<222>  (1)..(12)
<223>  Cysteine residues 1 and 12 are disulfide bonded

<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Residues 2, 3 and 4 can be present or absent

<220>
<221>  MISC_FEATURE
<222>  (9)..(11)
<223>  Residues 9, 10 and 11 can be present or absent

<400>  6

Cys Xaa Xaa Xaa Asp Met Phe Gly Xaa Xaa Xaa Cys 
1               5                   10          


<210>  7
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Either Xaa1 or Xaa2 is C and Xaa2 can be absent if Xaa1 is C

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Position three is L, M, I, V or A

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Position four is I, M or F

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Position five is D or C

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Position six is M or I

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Position seven is F or Y

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Position eight is G

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Position nine is any amino acid except C or P

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  If position 11 or 12 is C, position 10 is any amino acid except C
       and can be absent

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Position 11 is C or H unless position 10 or 12 is C and then 
       position 11 is not C

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Position 12 is C or H unless position 10 or 11 is C and then 
       position 12 is not C

<400>  7

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10          


<210>  8
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Either Xaa1 or Xaa2 is C and Xaa2 can be absent if Xaa1 is C

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Position 3 is not C, G, P, Q or T

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Position 4 is not A, G, P or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Position 5 is D or C

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Position 6 is M or I

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Position 7 is F or Y

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Position 8 is not A, R, S or V

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Position 9 is not C or P

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  If position 11 or 12 is C, position 10 is any amino acid except C
       and can be absent

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Position 11 is C or H unless position 10 or 12 is C and then 
       position 11 is not C

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Position 12 is C or H unless position 10 or 11 is C and then 
       position 12 is not C

<400>  8

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10          


<210>  9
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  9

Ser Thr Cys Leu Ile Asp Met Tyr Gly Val Cys His 
1               5                   10          


<210>  10
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  10

Ser Thr Cys Leu Ile Asp Met Tyr Gly Val Cys His Ser Ser Cys Leu 
1               5                   10                  15      


Ile Asp Met Tyr Gly Val Cys His 
            20                  


<210>  11
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  11

Ser Thr Cys Leu Ile Ala Met Tyr Gly Val Cys His 
1               5                   10          


<210>  12
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  12

Ser Thr Cys Leu Ile Glu Met Tyr Gly Val Cys His 
1               5                   10          


<210>  13
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  13

Ser Thr Cys Leu Ile Asp Met Tyr Ser Val Cys His 
1               5                   10          


<210>  14
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  14

Phe Leu Ser Phe Val Phe Pro Ala Ser Ala Trp Gly Gly 
1               5                   10              


<210>  15
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  15

Phe Tyr Met Pro Phe Gly Pro Thr Trp Trp Gln His Val 
1               5                   10              


<210>  16
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  16

Leu Phe Ser Trp Phe Leu Pro Thr Asp Asn Tyr Pro Val 
1               5                   10              


<210>  17
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  17

Phe Met Asp Ile Trp Ser Pro Trp His Leu Leu Gly Thr 
1               5                   10              


<210>  18
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  18

Phe Ser Ser Leu Phe Phe Pro His Trp Pro Ala Gln Leu 
1               5                   10              


<210>  19
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  19

Ser Cys Ala Met Ala Gln Trp Phe Cys Asp Arg Ala Glu Pro His His 
1               5                   10                  15      


Val Ile Ser 
            


<210>  20
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  20

Ser Cys Asn Met Ser His Leu Thr Gly Val Ser Leu Cys Asp Ser Leu 
1               5                   10                  15      


Ala Thr Ser 
            


<210>  21
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  21

Ser Cys Val Tyr Ser Phe Ile Asp Gly Ser Gly Cys Asn Ser His Ser 
1               5                   10                  15      


Leu Gly Ser 
            


<210>  22
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  22

Ser Cys Ser Gly Phe His Leu Leu Cys Glu Ser Arg Ser Met Gln Arg 
1               5                   10                  15      


Glu Leu Ser 
            


<210>  23
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  23

Ser Cys Gly Ile Leu Cys Ser Ala Phe Pro Phe Asn Asn His Gln Val 
1               5                   10                  15      


Gly Ala Ser 
            


<210>  24
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  24

Ser Cys Cys Ser Met Phe Phe Lys Asn Val Ser Tyr Val Gly Ala Ser 
1               5                   10                  15      


Asn Pro Ser 
            


<210>  25
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  25

Ser Cys Pro Ile Trp Lys Tyr Cys Asp Asp Tyr Ser Arg Ser Gly Ser 
1               5                   10                  15      


Ile Phe Ser 
            


<210>  26
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  26

Ser Cys Leu Phe Asn Ser Met Lys Cys Leu Val Leu Ile Leu Cys Phe 
1               5                   10                  15      


Val Ser 
        


<210>  27
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  27

Ser Cys Tyr Val Asn Gly His Asn Ser Val Trp Val Val Val Phe Trp 
1               5                   10                  15      


Gly Val Ser 
            


<210>  28
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  28

Ser Cys Asp Phe Val Cys Asn Val Leu Phe Asn Val Asn His Gly Ser 
1               5                   10                  15      


Asn Met Ser 
            


<210>  29
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  29

Ser Cys Leu Asn Lys Phe Phe Val Leu Met Ser Val Gly Leu Arg Ser 
1               5                   10                  15      


Tyr Thr Ser 
            


<210>  30
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  30

Ser Cys Cys Asn His Asn Ser Thr Ser Val Lys Asp Val Gln Phe Pro 
1               5                   10                  15      


Thr Leu Ser 
            


<210>  31
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  31

Phe Phe Pro Ser Ser Trp Tyr Ser His Leu Gly Val Leu 
1               5                   10              


<210>  32
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  32

Phe Phe Gly Phe Asp Val Tyr Asp Met Ser Asn Ala Leu 
1               5                   10              


<210>  33
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  33

Leu Ser Phe Ser Asp Phe Tyr Phe Ser Glu Gly Ser Glu 
1               5                   10              


<210>  34
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  34

Phe Ser Tyr Ser Val Ser Tyr Ala His Pro Glu Gly Leu 
1               5                   10              


<210>  35
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  35

Leu Pro His Leu Ile Gln Tyr Arg Val Leu Leu Val Ser 
1               5                   10              


<210>  36
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  36

Ser Cys Tyr Val Asn Gly His Asn Ser Val Trp Val Val Val Phe Trp 
1               5                   10                  15      


Gly Val Ser 
            


<210>  37
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  37

Ser Cys Asn Ser Phe Met Phe Ile Asn Gly Ser Phe Lys Glu Thr Gly 
1               5                   10                  15      


Gly Cys Ser 
            


<210>  38
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  38

Ser Cys Phe Gly Asn Leu Gly Asn Leu Ile Tyr Thr Cys Asp Arg Leu 
1               5                   10                  15      


Met Pro Ser 
            


<210>  39
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  39

Ser Cys Ser Phe Phe Met Pro Trp Cys Asn Phe Leu Asn Gly Glu Met 
1               5                   10                  15      


Ala Val Ser 
            


<210>  40
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  40

Ser Cys Phe Gly Asn Val Phe Cys Val Tyr Asn Gln Phe Ala Ala Gly 
1               5                   10                  15      


Leu Phe Ser 
            


<210>  41
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  41

Ser Cys Cys Phe Ile Asn Ser Asn Phe Ser Val Met Asn His Ser Leu 
1               5                   10                  15      


Phe Lys Ser 
            


<210>  42
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  42

Ser Cys Asp Tyr Phe Ser Phe Leu Glu Cys Phe Ser Asn Gly Trp Ser 
1               5                   10                  15      


Gly Ala Ser 
            


<210>  43
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  43

Ser Cys Trp Met Gly Leu Phe Glu Cys Pro Asp Ala Trp Leu His Asp 
1               5                   10                  15      


Trp Asp Ser 
            


<210>  44
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  44

Ser Cys Phe Trp Tyr Ser Trp Leu Cys Ser Ala Ser Ser Ser Asp Ala 
1               5                   10                  15      


Leu Ile Ser 
            


<210>  45
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  45

Ser Cys Phe Gly Asn Phe Leu Ser Phe Gly Phe Asn Cys Glu Ser Ala 
1               5                   10                  15      


Leu Gly Ser 
            


<210>  46
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  46

Ser Cys Leu Tyr Cys His Leu Asn Asn Gln Phe Leu Ser Trp Val Ser 
1               5                   10                  15      


Gly Asn Ser 
            


<210>  47
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  47

Ser Cys Phe Gly Phe Ser Asp Cys Leu Ser Trp Phe Val Gln Pro Ser 
1               5                   10                  15      


Thr Ala Ser 
            


<210>  48
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  48

Ser Cys Asn His Leu Gly Phe Phe Ser Ser Phe Cys Asp Arg Leu Val 
1               5                   10                  15      


Glu Asn Ser 
            


<210>  49
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  49

Ser Cys Gly Tyr Phe Cys Ser Phe Tyr Asn Tyr Leu Asp Ile Gly Thr 
1               5                   10                  15      


Ala Ser Ser 
            


<210>  50
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  50

Ser Cys Asn Ser Ser Ser Tyr Ser Trp Tyr Cys Trp Phe Gly Gly Ser 
1               5                   10                  15      


Ser Pro Ser 
            


<210>  51
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  51

Phe Gly His Gly Trp Leu Asn Thr Leu Asn Leu Gly Trp 
1               5                   10              


<210>  52
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  52

Phe Ser Pro Phe Ser Ala Asn Leu Trp Tyr Asp Met Phe 
1               5                   10              


<210>  53
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  53

Val Phe Val Pro Phe Gly Asn Trp Leu Ser Thr Ser Val 
1               5                   10              


<210>  54
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  54

Phe Trp Asn Val Asn Tyr Asn Pro Trp Gly Trp Asn Tyr 
1               5                   10              


<210>  55
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  55

Phe Tyr Trp Asp Arg Leu Asn Val Gly Trp Gly Leu Leu 
1               5                   10              


<210>  56
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  56

Leu Tyr Ser Thr Met Tyr Pro Gly Met Ser Trp Leu Val 
1               5                   10              


<210>  57
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  57

Ser Cys Phe Tyr Gln Asn Val Ile Ser Ser Ser Phe Ala Gly Asn Pro 
1               5                   10                  15      


Trp Glu Cys 
            


<210>  58
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  58

Ser Cys Asn Met Leu Leu Asn Ser Leu Pro Leu Pro Ser Glu Asp Trp 
1               5                   10                  15      


Ser Ala Cys 
            


<210>  59
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  59

Ser Cys Pro Phe Thr His Ser Leu Ala Leu Asn Thr Asp Arg Ala Ser 
1               5                   10                  15      


Pro Gly Cys 
            


<210>  60
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  60

Ser Cys Phe Glu Ser Asp Phe Pro Asn Val Arg His His Val Leu Lys 
1               5                   10                  15      


Gln Ser Cys 
            


<210>  61
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  61

Ser Cys Val Phe Asp Ser Lys His Phe Ser Pro Thr His Ser Pro His 
1               5                   10                  15      


Asp Val Cys 
            


<210>  62
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  62

Ser Cys Gly Asp His Met Thr Asp Lys Asn Met Pro Asn Ser Gly Ile 
1               5                   10                  15      


Ser Gly Cys 
            


<210>  63
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  63

Ser Cys Asp Phe Phe Asn Arg His Gly Tyr Asn Ser Gly Cys Glu His 
1               5                   10                  15      


Ser Val Cys 
            


<210>  64
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  64

Ser Cys Gly Asp His Met Thr Asp Lys Asn Met Pro Asn Ser Gly Ile 
1               5                   10                  15      


Ser Gly Cys 
            


<210>  65
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  65

Ser Cys Tyr Tyr Asn Gly Leu Val Val His His Ser Asn Ser Gly His 
1               5                   10                  15      


Lys Asp Cys 
            


<210>  66
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  66

Cys Trp Ser Arg Phe Arg Leu Phe Met Leu Phe Cys Met Phe Tyr Leu 
1               5                   10                  15      


Val Ser 
        


<210>  67
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  67

Cys Ile Lys Tyr Pro Phe Leu Tyr Cys Cys Leu Leu Ser Leu Phe Leu 
1               5                   10                  15      


Phe Ser 
        


<210>  68
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  68

Ser Trp Trp Gly Phe Trp Asn Gly Ser Ala Ala Pro Val Trp Ser Arg 
1               5                   10                  15      


<210>  69
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  69

Ser Trp Asp Phe Arg Ser Leu Arg Asp Trp Trp Pro Pro Ala Pro Ser 
1               5                   10                  15      


Leu Ser Ser Arg 
            20  


<210>  70
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  70

Ser Ile Phe Ser Thr Trp Asn Pro Trp Ser Pro Tyr Ser Val Ser Arg 
1               5                   10                  15      


<210>  71
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  71

Ser Phe Gly Ser Trp Trp Trp Gly Ser Gly Ala Ala Ser Ser Arg 
1               5                   10                  15  


<210>  72
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  72

Ser Cys Phe Trp Phe Leu Arg Trp Ser Leu Phe Ile Val Leu Phe Thr 
1               5                   10                  15      


Cys Cys Ser 
            


<210>  73
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  73

Ser Cys Glu Ser Val Asp Cys Phe Ala Asp Ser Arg Met Ala Lys Val 
1               5                   10                  15      


Ser Met Ser 
            


<210>  74
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  74

Ser Cys Val Gly Phe Phe Cys Ile Thr Gly Ser Asp Val Ala Ser Val 
1               5                   10                  15      


Asn Ser Ser 
            


<210>  75
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  75

Ser Cys Ser Asp Cys Leu Lys Ser Val Asp Phe Ile Pro Ser Ser Leu 
1               5                   10                  15      


Ala Ser Ser 
            


<210>  76
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  76

Ser Cys Ala Phe Asp Cys Pro Ser Ser Val Ala Arg Ser Pro Gly Glu 
1               5                   10                  15      


Trp Ser Ser 
            


<210>  77
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  77

Ser Cys Val Asp Val Met His Ala Asp Ser Pro Gly Pro Asp Gly Leu 
1               5                   10                  15      


Asn Ser 
        


<210>  78
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  78

Ser Cys Ser Ser Phe Glu Val Ser Glu Met Phe Thr Cys Ala Val Ser 
1               5                   10                  15      


Ser Tyr Ser 
            


<210>  79
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  79

Ser Cys Gly Leu Asn Phe Pro Leu Cys Ser Phe Val Asp Phe Ala Gln 
1               5                   10                  15      


Asp Ala Ser 
            


<210>  80
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  80

Ser Cys Met Leu Phe Ser Ser Val Phe Asp Cys Gly Met Leu Ile Ser 
1               5                   10                  15      


Asp Leu Ser 
            


<210>  81
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  81

Ser Cys Val Asp Tyr Val Met His Ala Asp Ser Pro Gly Pro Asp Gly 
1               5                   10                  15      


Leu Asn Ser 
            


<210>  82
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  82

Ser Cys Ser Glu Asn Phe Met Phe Asn Met Tyr Gly Thr Gly Val Cys 
1               5                   10                  15      


Thr Glu Ser 
            


<210>  83
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  83

His Lys His Pro Val Thr Pro Arg Phe Phe Val Val Glu 
1               5                   10              


<210>  84
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  84

Cys Asn Cys Tyr Val Thr Pro Asn Leu Leu Lys His Lys Cys Tyr Lys 
1               5                   10                  15      


Ile Cys 
        


<210>  85
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  85

Cys Ser His Asn His His Lys Leu Thr Ala Lys His Gln Val Ala His 
1               5                   10                  15      


Lys Cys 
        


<210>  86
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  86

Cys Asp Gln Asn Asp Ile Phe Tyr Thr Ser Lys Lys Ser His Lys Ser 
1               5                   10                  15      


His Cys 
        


<210>  87
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  87

Ser Ser Asp Val Tyr Leu Val Ser His Lys His His Leu Thr Arg His 
1               5                   10                  15      


Asn Ser 
        


<210>  88
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  88

Ser Asp Lys Cys His Lys His Trp Tyr Cys Tyr Glu Ser Lys Tyr Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  89
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  89

Ser Asp Lys Ser His Lys His Trp Tyr Ser Tyr Glu Ser Lys Tyr Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  90
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  90

His His Lys Leu Lys His Gln Met Leu His Leu Asn Gly Gly 
1               5                   10                  


<210>  91
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  91

Gly His His His Lys Lys Asp Gln Leu Pro Gln Leu Gly Gly 
1               5                   10                  


<210>  92
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  92

Ser Ser His Lys His Pro Val Thr Pro Arg Phe Phe Val Val Glu Ser 
1               5                   10                  15      


Arg 
    


<210>  93
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  93

Ser Ser Cys Asn Cys Tyr Val Thr Pro Asn Leu Leu Lys His Lys Cys 
1               5                   10                  15      


Tyr Lys Ile Cys Ser Arg 
            20          


<210>  94
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  94

Ser Ser Cys Ser His Asn His His Lys Leu Thr Ala Lys His Gln Val 
1               5                   10                  15      


Ala His Lys Cys Ser Arg 
            20          


<210>  95
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  95

Ser Ser Cys Asp Gln Asn Asp Ile Phe Tyr Thr Ser Lys Lys Ser His 
1               5                   10                  15      


Lys Ser His Cys Ser Arg 
            20          


<210>  96
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  96

Ser Ser Ser Ser Asp Val Tyr Leu Val Ser His Lys His His Leu Thr 
1               5                   10                  15      


Arg His Asn Ser Ser Arg 
            20          


<210>  97
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  97

Ser Ser Ser Asp Lys Cys His Lys His Trp Tyr Cys Tyr Glu Ser Lys 
1               5                   10                  15      


Tyr Gly Gly Ser Ser Arg 
            20          


<210>  98
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  98

His His Lys Leu Lys His Gln Met Leu His Leu Asn Gly Gly 
1               5                   10                  


<210>  99
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  99

Gly His His His Lys Lys Asp Gln Leu Pro Gln Leu Gly Gly 
1               5                   10                  


<210>  100
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  100

Cys Phe Val Leu Asn Cys His Leu Val Leu Asp Arg Pro 
1               5                   10              


<210>  101
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  101

Ser Cys Phe Gly Asn Phe Leu Ser Phe Gly Phe Asn Cys Glu Tyr Ala 
1               5                   10                  15      


Leu Gly Ser 
            


<210>  102
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  102

Asp Gly Phe Phe Ile Leu Tyr Lys Asn Pro Asp Val Leu 
1               5                   10              


<210>  103
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  103

Asn His Gln Asn Gln Thr Asn 
1               5           


<210>  104
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  104

Ala Thr His Met Val Gly Ser 
1               5           


<210>  105
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  105

Gly Ile Asn Pro Asn Phe Ile 
1               5           


<210>  106
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  106

Thr Ala Ile Ser Gly His Phe 
1               5           


<210>  107
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  107

Leu Tyr Gly Thr Pro Glu Tyr Ala Val Gln Pro Leu Arg 
1               5                   10              


<210>  108
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  108

Cys Phe Leu Thr Gln Asp Tyr Cys Val Leu Ala Gly Lys 
1               5                   10              


<210>  109
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  109

Val Leu His Leu Asp Ser Tyr Gly Pro Ser Val Pro Leu 
1               5                   10              


<210>  110
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  110

Val Val Asp Ser Thr Gly Tyr Leu Arg Pro Val Ser Thr 
1               5                   10              


<210>  111
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  111

Val Leu Gln Asn Ala Thr Asn Val Ala Pro Phe Val Thr 
1               5                   10              


<210>  112
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  112

Trp Trp Ser Ser Met Pro Tyr Val Gly Asp Tyr Thr Ser 
1               5                   10              


<210>  113
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  113

Ser Ser Tyr Phe Asn Leu Gly Leu Val Lys His Asn His Val Arg His 
1               5                   10                  15      


His Asp Ser 
            


<210>  114
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  114

Cys His Asp His Ser Asn Lys Tyr Leu Lys Ser Trp Lys His Gln Gln 
1               5                   10                  15      


Asn Cys 
        


<210>  115
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  115

Ser Cys Lys His Asp Ser Glu Phe Ile Lys Lys His Val His Ala Val 
1               5                   10                  15      


Lys Lys Cys 
            


<210>  116
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  116

Ser Cys His His Leu Lys His Asn Thr His Lys Glu Ser Lys Met His 
1               5                   10                  15      


His Glu Cys 
            


<210>  117
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  117

Val Asn Lys Met Asn Arg Leu Trp Glu Pro Leu 
1               5                   10      


<210>  118
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  118

Ser Ser His Arg Thr Asn His Lys Lys Asn Asn Pro Lys Lys Lys Asn 
1               5                   10                  15      


Lys Thr Arg 
            


<210>  119
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized

<400>  119

Asn His Thr Ile Ser Lys Asn His Lys Lys Lys Asn Lys Asn Ser Asn 
1               5                   10                  15      


Lys Thr Arg 
            


<210>  120
<211>  49
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Residue 25 is a linker comprised of 2 PEG [poly(ethylene) glycol]
       units having the shortest ether structure possible of PEG with 
       two ethylene oxide unitsas follows:

       (HN-CH2-CH2-O-CH2-CH2-O-CH2-C=O)2

<400>  120

Ser Ser Ser Cys Leu Ile Asp Met Tyr Gly Val Cys His Asn Phe Asp 
1               5                   10                  15      


Gly Ala Tyr Asp Ser Ser Arg Gly Xaa Ser Ser His Arg Thr Asn His 
            20                  25                  30          


Lys Lys Asn Asn Pro Lys Lys Lys Asn Lys Thr Arg Gly Ser Ser Gly 
        35                  40                  45              


Lys 
    


<210>  121
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  Synthesized

<400>  121
tgtttgattg atatgtatgg tgtttgccat aattttgatg gggcgtatga tagc           54


<210>  122
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  Synthesized

<400>  122
tgtctgtttg atatttttgg tgtttgtcac agctttgatg gggcgtatga tagc           54


<210>  123
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Synthesized

<400>  123
ccgtgtgagc tgattgatat gtttgggaat gatcattgtc cg                        42


<210>  124
<211>  49
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4 residues of aminoundecanoic acid ("AUD") are added sequentially
       to the N-terminus during linear synthesis

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Residue 25 is a linker comprised of 2 PEG [poly(ethylene) glycol]
       units having the shortest ether structure possible of PEG with 
       two ethylene oxide unitsas follows:

       (HN-CH2-CH2-O-CH2-CH2-O-CH2-C=O)2

<400>  124

Ser Ser Ser Cys Leu Ile Asp Met Tyr Gly Val Cys His Asn Phe Asp 
1               5                   10                  15      


Gly Ala Tyr Asp Ser Ser Arg Gly Xaa Ser Ser His Arg Thr Asn His 
            20                  25                  30          


Lys Lys Asn Asn Pro Lys Lys Lys Asn Lys Thr Arg Gly Ser Ser Gly 
        35                  40                  45              


Lys 
    


<210>  125
<211>  35
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  A myristic acid and an aminohexanoic acid are added to the 
       N-terminus during linear synthesis

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Residue 18 is a linker comprised of 2 PEG [poly(ethylene) glycol]
       units having the shortest ether structure possible of PEG with 
       two ethylene oxide unitsas follows:

       (HN-CH2-CH2-O-CH2-CH2-O-CH2-C=O)2

<400>  125

Ser Ser Cys Leu Ile Asp Ile Tyr Gly Val Cys His Asn Phe Asp Ala 
1               5                   10                  15      


Tyr Xaa His Lys Lys Asn Asn Pro Lys Lys Lys Asn Lys Thr Arg Gly 
            20                  25                  30          


Ser Ser Lys 
        35  


<210>  126
<211>  35
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  3 residues of aminoundecanoic acid ("AUD") are added sequentially
       to the N-terminus during linear synthesis

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Residue 18 is a linker comprised of 2 PEG [poly(ethylene) glycol]
       units having the shortest ether structure possible of PEG with 
       two ethylene oxide unitsas follows:

       (HN-CH2-CH2-O-CH2-CH2-O-CH2-C=O)2

<400>  126

Ser Ser Cys Leu Ile Asp Ile Tyr Gly Val Cys His Asn Phe Asp Ala 
1               5                   10                  15      


Tyr Xaa His Lys Lys Asn Asn Pro Lys Lys Lys Asn Lys Thr Arg Gly 
            20                  25                  30          


Ser Ser Lys 
        35  


<210>  127
<211>  35
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  4 residues of aminoundecanoic acid ("AUD") are added sequentially
       to the N-terminus during linear synthesis

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Residue 18 is a linker comprised of 2 PEG [poly(ethylene) glycol]
       units having the shortest ether structure possible of PEG with 
       two ethylene oxide unitsas follows:

       (HN-CH2-CH2-O-CH2-CH2-O-CH2-C=O)2

<400>  127

Ser Ser Cys Leu Ile Asp Ile Tyr Gly Val Cys His Asn Phe Asp Ala 
1               5                   10                  15      


Tyr Xaa His Lys Lys Asn Asn Pro Lys Lys Lys Asn Lys Thr Arg Gly 
            20                  25                  30          


Ser Ser Lys 
        35  


<210>  128
<211>  40
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Residue 18 is a linker comprised of 2 PEG [poly(ethylene) glycol]
       units having the shortest ether structure possible of PEG with 
       two ethylene oxide unitsas follows:

       (HN-CH2-CH2-O-CH2-CH2-O-CH2-C=O)2

<400>  128

Ser Ser Cys Leu Ile Asp Ile Tyr Gly Val Cys His Asn Phe Asp Ala 
1               5                   10                  15      


Tyr Xaa Tyr Phe Arg Ala Phe Arg Lys Phe Val Lys Pro Phe Lys Arg 
            20                  25                  30          


Ala Phe Lys Gly Ser Ser Gly Lys 
        35                  40  


<210>  129
<211>  40
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  A myristic acid and an aminohexanoic acid are added to the 
       N-terminus during linear synthesis

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Residue 18 is a linker comprised of 2 PEG [poly(ethylene) glycol]
       units having the shortest ether structure possible of PEG with 
       two ethylene oxide unitsas follows:

       (HN-CH2-CH2-O-CH2-CH2-O-CH2-C=O)2

<400>  129

Ser Ser Cys Leu Ile Asp Ile Tyr Gly Val Cys His Asn Phe Asp Ala 
1               5                   10                  15      


Tyr Xaa Tyr Phe Arg Ala Phe Arg Lys Phe Val Lys Pro Phe Lys Arg 
            20                  25                  30          


Ala Phe Lys Gly Ser Ser Gly Lys 
        35                  40  


<210>  130
<211>  35
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Residue 18 is a linker comprised of 2 PEG [poly(ethylene) glycol]
       units having the shortest ether structure possible of PEG with 
       two ethylene oxide unitsas follows:

       (HN-CH2-CH2-O-CH2-CH2-O-CH2-C=O)2

<400>  130

Ser Ser Cys Leu Ile Asp Ile Tyr Gly Val Cys His Asn Phe Asp Ala 
1               5                   10                  15      


Tyr Xaa His Lys Lys Asn Asn Pro Lys Lys Lys Asn Lys Thr Arg Gly 
            20                  25                  30          


Ser Ser Lys 
        35  


<210>  131
<211>  42
<212>  PRT
<213>  Artificial

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Residue 18 is a linker comprised of 2 PEG [poly(ethylene) glycol]
       units having the shortest ether structure possible of PEG with 
       two ethylene oxide unitsas follows:

       (HN-CH2-CH2-O-CH2-CH2-O-CH2-C=O)2

<400>  131

Ser Ser Cys Leu Ile Asp Ile Tyr Gly Val Cys His Asn Phe Asp Ala 
1               5                   10                  15      


Tyr Xaa Ser Ser His Arg Thr Asn His Lys Lys Asn Asn Pro Lys Lys 
            20                  25                  30          


Lys Asn Lys Thr Arg Gly Ser Ser Gly Lys 
        35                  40          


