                         SEQUENCE LISTING

<110>  Abo, Arie
       Korver, Wouter
 
<120>  ANTIBODIES TO IREM-1

<130>  NUVO-32/PCT

<140>  Not Yet Assigned
<141>  2008-10-01

<150>  60/980,369
<151>  2007-10-16

<160>  59    

<170>  PatentIn version 3.4

<210>  1
<211>  1759
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (104)..(976)

<400>  1
aagttcaagg gcgagagtga gtaccagcag aaggctggga gtctgtagtt tgttcctgct     60

gccaggctcc actgagggga acggggacct gtctgaagag aag atg ccc ctg ctg      115
                                                Met Pro Leu Leu         
                                                1                       

aca ctc tac ctg ctc ctc ttc tgg ctc tca ggc tac tcc att gtc act      163
Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr Ser Ile Val Thr         
5                   10                  15                  20          

caa atc acc ggt cca aca aca gtg aat ggc ttg gag cgg ggc tcc ttg      211
Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu Arg Gly Ser Leu         
                25                  30                  35              

acc gtg cag tgt gtt tac aga tca ggc tgg gag acc tac ttg aag tgg      259
Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr Tyr Leu Lys Trp         
            40                  45                  50                  

tgg tgt cga gga gct att tgg cgt gac tgc aag atc ctt gtt aaa acc      307
Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile Leu Val Lys Thr         
        55                  60                  65                      

agt ggg tca gag cag gag gtg aag agg gac cgg gtg tcc atc aag gac      355
Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val Ser Ile Lys Asp         
    70                  75                  80                          

aat cag aaa aac cgc acg ttc act gtg acc atg gag gat ctc atg aaa      403
Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu Asp Leu Met Lys         
85                  90                  95                  100         

act gat gct gac act tac tgg tgt gga att gag aaa act gga aat gac      451
Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys Thr Gly Asn Asp         
                105                 110                 115             

ctt ggg gtc aca gtt caa gtg acc att gac cca gca cca gtc acc caa      499
Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala Pro Val Thr Gln         
            120                 125                 130                 

gaa gaa act agc agc tcc cca act ctg acc ggc cac cac ttg gac aac      547
Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His His Leu Asp Asn         
        135                 140                 145                     

agg cac aag ctc ctg aag ctc agt gtc ctc ctg ccc ctc atc ttc acc      595
Arg His Lys Leu Leu Lys Leu Ser Val Leu Leu Pro Leu Ile Phe Thr         
    150                 155                 160                         

ata ttg ctg ctg ctt ttg gtg gcc gcc tca ctc ttg gct tgg agg atg      643
Ile Leu Leu Leu Leu Leu Val Ala Ala Ser Leu Leu Ala Trp Arg Met         
165                 170                 175                 180         

atg aag tac cag cag aaa gca gcc ggg atg tcc cca gag cag gta ctg      691
Met Lys Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro Glu Gln Val Leu         
                185                 190                 195             

cag ccc ctg gag ggc gac ctc tgc tat gca gac ctg acc ctg cag ctg      739
Gln Pro Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu Thr Leu Gln Leu         
            200                 205                 210                 

gcc gga acc tcc ccg caa aag gct acc acg aag ctt tcc tct gcc cag      787
Ala Gly Thr Ser Pro Gln Lys Ala Thr Thr Lys Leu Ser Ser Ala Gln         
        215                 220                 225                     

gtt gac cag gtg gaa gtg gaa tat gtc acc atg gct tcc ttg ccg aag      835
Val Asp Gln Val Glu Val Glu Tyr Val Thr Met Ala Ser Leu Pro Lys         
    230                 235                 240                         

gag gac att tcc tat gca tct ctg acc ttg ggt gct gag gat cag gaa      883
Glu Asp Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala Glu Asp Gln Glu         
245                 250                 255                 260         

ccg acc tac tgc aac atg ggc cac ctc agt agc cac ctc ccc ggc agg      931
Pro Thr Tyr Cys Asn Met Gly His Leu Ser Ser His Leu Pro Gly Arg         
                265                 270                 275             

ggc cct gag gag ccc acg gaa tac agc acc atc agc agg cct tag          976
Gly Pro Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser Arg Pro                 
            280                 285                 290                 

cctgcactcc aggctccttc ttggacccca ggctgtgagc acactcctgc ctcatcgacc   1036

gtctgccccc tgctcccctc atcaggacca acccggggac tggtgcctct gcctgatcag   1096

ccagcattgc ccctagctct gggttgggct tggggccaag tctcaggggg cttctaggag   1156

ttggggtttt ctaaacgtcc cctcctctcc tacatagttg aggagggggc tagggatatg   1216

ctctggggct ttcatgggaa tgatgaagat gataatgaga aaaatgttat cattattatc   1276

atgaagtacc attatcgtaa tacaatgaac ctttatttat tgcctaccac atgttatggg   1336

ctgaataatg gcccccaaag atatctgtgt cctaatcctc agaacctgtg actgttacct   1396

tctgtggcag aaagggacag tgcagatgta tgtaagttaa ggactttgag atagagaggt   1456

tattcttgct gattcaggtg ggcccaaaat atcaccacaa gggtcctcat aagaaagagg   1516

ccagaaggtc aaagaggtag agacaaagtg atgatggaag tggacgtggg tgtgacgtga   1576

gcaggggcca tgaatgccgc agccttcaga tgccagaaag ggaaaggaat ggattcccct   1636

gcctggagcc tccaaaagaa accagccctg cccacgcctt gacttgagcc cattgaaact   1696

gatcttgagc tcctggcctc cagaattgca ggagaataaa tttgtgttgt ttttaatgag   1756

cca                                                                 1759


<210>  2
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Leu Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr 
1               5                   10                  15      


Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu 
            20                  25                  30          


Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr 
        35                  40                  45              


Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile 
    50                  55                  60                  


Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val 
65                  70                  75                  80  


Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu 
                85                  90                  95      


Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys 
            100                 105                 110         


Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala 
        115                 120                 125             


Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His 
    130                 135                 140                 


His Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val Leu Leu Pro 
145                 150                 155                 160 


Leu Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala Ser Leu Leu 
                165                 170                 175     


Ala Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro 
            180                 185                 190         


Glu Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu 
        195                 200                 205             


Thr Leu Gln Leu Ala Gly Thr Ser Pro Gln Lys Ala Thr Thr Lys Leu 
    210                 215                 220                 


Ser Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val Thr Met Ala 
225                 230                 235                 240 


Ser Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala 
                245                 250                 255     


Glu Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu Ser Ser His 
            260                 265                 270         


Leu Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser 
        275                 280                 285             


Arg Pro 
    290 


<210>  3
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  3

Tyr Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu 
1               5                   10                  15      


Glu Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu 
            20                  25                  30          


Thr Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys 
        35                  40                  45              


Ile Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg 
    50                  55                  60                  


Val Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met 
65                  70                  75                  80  


Glu Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu 
                85                  90                  95      


Lys Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro 
            100                 105                 110         


Ala Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly 
        115                 120                 125             


His His Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser 
    130                 135                 140     


<210>  4
<211>  387
<212>  DNA
<213>  Mus musculus

<400>  4
ttccagtgtg aggtgaagct ggtggagtct ggaggaggct tggttcagcc tgggggttct     60

ctgagtctct cctgtgcagc ttctggattc accttcactg attactacat gagctgggtc    120

cgccagcctc cagggatggc acctgagtgg ttgggtttta ttagaaacaa agctaacggt    180

tacacaacag agtacagtgc atctgtgaag ggtcggttca ccatctccag agatgattcc    240

caaagcatcc tctatcttca aatgaatgcc ctgagagctg aggacagtgc cacttattac    300

tgtgcaagag aggactacgg tagtagctgg ggttactatg ctatggactg ctggggtcaa    360

ggaacctcag tcaccgtctc ctcagcc                                        387


<210>  5
<211>  481
<212>  PRT
<213>  Mus musculus

<400>  5

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ser Phe Gln Cys Glu Val Lys Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg 
    50                  55                  60                  


Gln Pro Pro Gly Met Ala Pro Glu Trp Leu Gly Phe Ile Arg Asn Lys 
65                  70                  75                  80  


Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe 
                85                  90                  95      


Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn 
            100                 105                 110         


Ala Leu Arg Ala Glu Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Glu Asp 
        115                 120                 125             


Tyr Gly Ser Ser Trp Gly Tyr Tyr Ala Met Asp Cys Trp Gly Gln Gly 
    130                 135                 140                 


Thr Ser Val Thr Val Ser Ser Ala Arg Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  6
<211>  327
<212>  DNA
<213>  Mus musculus

<400>  6
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc     60

gtcacctgca aggccagtca gaatgtggat actaatgtag cctggtatca gcagaaacca    120

gggcaatctc ctaaagcact gctttattcg gcatcctacc ggcacagtgg agtccctgat    180

cgcttcacag gcagtggatc tgaaacagat ttcactctca ccatcaccaa tgtgcagtct    240

gaagacttgg cagagtattt ctgtcagcaa tataacagct ttcctcttac attcggctcg    300

gggacaaagt tggaaataag acgggct                                        327


<210>  7
<211>  237
<212>  PRT
<213>  Mus musculus

<400>  7

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ser Asp Ile Val Met Thr Gln Ser Gln Lys 
            20                  25                  30          


Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala 
        35                  40                  45              


Ser Gln Asn Val Asp Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Ser Pro Lys Ala Leu Leu Tyr Ser Ala Ser Tyr Arg His Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Thr Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln 
            100                 105                 110         


Gln Tyr Asn Ser Phe Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Arg Arg Ala Ala Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  8
<211>  353
<212>  DNA
<213>  Mus musculus

<400>  8
cagatccagt tggtgcaatc tggacctgag ctggagaagc ctggagagac agtcaagatc     60

tcctgcaagg cttctgggta taccttcaca aactatccaa tgcactgggt gaagcaggct    120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct actctggagt gccaacatat    180

gcagatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcatat    240

ttgcagatca acaacctcaa aaatgaggac atggctacat atttctgtgc aagaatggac    300

tactatagta acggctttaa ctactggggc caaggcacca ctctcacagt ctc           353


<210>  9
<211>  472
<212>  PRT
<213>  Mus musculus

<400>  9

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ser Gln Ile Gln Leu Val Gln Ser Gly Pro 
            20                  25                  30          


Glu Leu Glu Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Asn Tyr Pro Met His Trp Val Lys Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Ser Gly Val 
65                  70                  75                  80  


Pro Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu 
                85                  90                  95      


Thr Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu 
            100                 105                 110         


Asp Met Ala Thr Tyr Phe Cys Ala Arg Met Asp Tyr Tyr Ser Asn Gly 
        115                 120                 125             


Phe Asn Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Arg 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  10
<211>  345
<212>  DNA
<213>  Mus musculus

<400>  10
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc     60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg    120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt    180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc    240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg    300

tggacgttcg gtggaggcac caagctggaa ataaaacggg ctgcg                    345


<210>  11
<211>  242
<212>  PRT
<213>  Mus musculus

<400>  11

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ser Asp Val Leu Met Thr Gln Thr Pro Leu 
            20                  25                  30          


Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
    50                  55                  60                  


Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
            100                 105                 110         


Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Trp Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Ala Pro Ser Val Phe 
    130                 135                 140                 


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
145                 150                 155                 160 


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
                165                 170                 175     


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
            180                 185                 190         


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
        195                 200                 205             


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
    210                 215                 220                 


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
225                 230                 235                 240 


Glu Cys 
        


<210>  12
<211>  363
<212>  DNA
<213>  Mus musculus

<400>  12
gagatccagc tgcagcagtc tggagctgag ctggtaaggc ctgggacttc agtgaaggtg     60

tcctgcaagg cttctggata cgccttcact aattacttga tagagtgggt aaaacagagg    120

cctggacagg gccttgagtg gattggagtg attaatcctg gaagtggtgg ttcttactac    180

aatgagaagt tcaagggcaa gacaacactg actgcagaca agtcctccag cactgcctac    240

atgcagctca gcagcctggc ttttgatgac tctgcggtct atttctgtgc aagatcggag    300

agtaactact catattacta tgctatggac tactggggtc aaggaacctc agtcatcgtc    360

tcc                                                                  363


<210>  13
<211>  475
<212>  PRT
<213>  Mus musculus

<400>  13

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ser Glu Ile Gln Leu Gln Gln Ser Gly Ala 
            20                  25                  30          


Glu Leu Val Arg Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Ala Phe Thr Asn Tyr Leu Ile Glu Trp Val Lys Gln Arg Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Trp Ile Gly Val Ile Asn Pro Gly Ser Gly Gly 
65                  70                  75                  80  


Ser Tyr Tyr Asn Glu Lys Phe Lys Gly Lys Thr Thr Leu Thr Ala Asp 
                85                  90                  95      


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Ala Phe Asp 
            100                 105                 110         


Asp Ser Ala Val Tyr Phe Cys Ala Arg Ser Glu Ser Asn Tyr Ser Tyr 
        115                 120                 125             


Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Ile Val Ser 
    130                 135                 140                 


Ser Ala Arg Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  14
<211>  339
<212>  DNA
<213>  Mus musculus

<400>  14
gaccttgtgc tgacacagtc tccagcttct ttggctgtgt ctctagggca gagggccacc     60

atctcctgca gagccagcga aagtgttgat aattatggca ttagttttat gaactggttc    120

caacagaaat caggacagcc acccaaagtc ctcatctatg ctgcatccaa ccgaggatcc    180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat    240

cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaactaagga ggttccgtac    300

acgttcggag gggggaccaa gctggaaatc aaacgggct                           339


<210>  15
<211>  241
<212>  PRT
<213>  Mus musculus

<400>  15

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ser Asp Leu Val Leu Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln 
    50                  55                  60                  


Gln Lys Ser Gly Gln Pro Pro Lys Val Leu Ile Tyr Ala Ala Ser Asn 
65                  70                  75                  80  


Arg Gly Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Ser Leu Asn Ile His Pro Met Glu Glu Asp Asp Thr Ala Met 
            100                 105                 110         


Tyr Phe Cys Gln Gln Thr Lys Glu Val Pro Tyr Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Ala Pro Ser Val Phe Ile 
    130                 135                 140                 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
145                 150                 155                 160 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
                165                 170                 175     


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
    210                 215                 220                 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
225                 230                 235                 240 


Cys 
    


<210>  16
<211>  342
<212>  PRT
<213>  Artificial

<220>
<223>  IgK-IREM-1 Del1-HA tag deletion construct


<220>
<221>  SIGNAL
<222>  (1)..(23)
<223>  IgK signal peptide

<220>
<221>  MISC_FEATURE
<222>  (24)..(311)
<223>  IREM-1 Del1 (begins at aa 18)

<220>
<221>  MISC_FEATURE
<222>  (312)..(342)
<223>  HA tag

<400>  16

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ser Ile Val Thr Gln Ile Thr Gly Pro Thr 
            20                  25                  30          


Thr Val Asn Gly Leu Glu Arg Gly Ser Leu Thr Val Gln Cys Val Tyr 
        35                  40                  45              


Arg Ser Gly Trp Glu Thr Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile 
    50                  55                  60                  


Trp Arg Asp Cys Lys Ile Leu Val Lys Thr Ser Gly Ser Glu Gln Glu 
65                  70                  75                  80  


Val Lys Arg Asp Arg Val Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr 
                85                  90                  95      


Phe Thr Val Thr Met Glu Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr 
            100                 105                 110         


Trp Cys Gly Ile Glu Lys Thr Gly Asn Asp Leu Gly Val Thr Val Gln 
        115                 120                 125             


Val Thr Ile Asp Pro Ala Ser Thr Pro Ala Pro Thr Thr Pro Thr Ser 
    130                 135                 140                 


Thr Thr Phe Thr Ala Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro 
145                 150                 155                 160 


Thr Leu Thr Gly His His Leu Asp Asn Arg His Lys Leu Leu Lys Leu 
                165                 170                 175     


Ser Val Leu Leu Pro Leu Ile Phe Thr Ile Leu Leu Leu Leu Leu Val 
            180                 185                 190         


Ala Ala Ser Leu Leu Ala Trp Arg Met Met Lys Tyr Gln Gln Lys Ala 
        195                 200                 205             


Ala Gly Met Ser Pro Glu Gln Val Leu Gln Pro Leu Glu Gly Asp Leu 
    210                 215                 220                 


Cys Tyr Ala Asp Leu Thr Leu Gln Leu Ala Gly Thr Ser Pro Arg Lys 
225                 230                 235                 240 


Ala Thr Thr Lys Leu Ser Ser Ala Gln Val Asp Gln Val Glu Val Glu 
                245                 250                 255     


Tyr Val Thr Met Ala Ser Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser 
            260                 265                 270         


Leu Thr Leu Gly Ala Glu Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly 
        275                 280                 285             


His Leu Ser Ser His Leu Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu 
    290                 295                 300                 


Tyr Ser Thr Ile Ser Arg Pro Ser Leu Glu Gly Pro Arg Phe Glu Gly 
305                 310                 315                 320 


Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Arg Thr Gly 
                325                 330                 335     


His His His His His His 
            340         


<210>  17
<211>  317
<212>  PRT
<213>  Artificial

<220>
<223>  IgK-IREM-1-Del2-HA deletion construct


<220>
<221>  SIGNAL
<222>  (1)..(23)
<223>  IgK signal peptide

<220>
<221>  MISC_FEATURE
<222>  (24)..(286)
<223>  IREM-1 Del2 (begins at aa 43)

<220>
<221>  MISC_FEATURE
<222>  (287)..(317)
<223>  HA tag

<400>  17

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ser Arg Ser Gly Trp Glu Thr Tyr Leu Lys 
            20                  25                  30          


Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile Leu Val Lys 
        35                  40                  45              


Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val Ser Ile Lys 
    50                  55                  60                  


Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu Asp Leu Met 
65                  70                  75                  80  


Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys Thr Gly Asn 
                85                  90                  95      


Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala Ser Thr Pro 
            100                 105                 110         


Ala Pro Thr Thr Pro Thr Ser Thr Thr Phe Thr Ala Pro Val Thr Gln 
        115                 120                 125             


Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His His Leu Asp Asn 
    130                 135                 140                 


Arg His Lys Leu Leu Lys Leu Ser Val Leu Leu Pro Leu Ile Phe Thr 
145                 150                 155                 160 


Ile Leu Leu Leu Leu Leu Val Ala Ala Ser Leu Leu Ala Trp Arg Met 
                165                 170                 175     


Met Lys Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro Glu Gln Val Leu 
            180                 185                 190         


Gln Pro Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu Thr Leu Gln Leu 
        195                 200                 205             


Ala Gly Thr Ser Pro Arg Lys Ala Thr Thr Lys Leu Ser Ser Ala Gln 
    210                 215                 220                 


Val Asp Gln Val Glu Val Glu Tyr Val Thr Met Ala Ser Leu Pro Lys 
225                 230                 235                 240 


Glu Asp Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala Glu Asp Gln Glu 
                245                 250                 255     


Pro Thr Tyr Cys Asn Met Gly His Leu Ser Ser His Leu Pro Gly Arg 
            260                 265                 270         


Gly Pro Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser Arg Pro Ser Leu 
        275                 280                 285             


Glu Gly Pro Arg Phe Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly 
    290                 295                 300                 


Leu Asp Ser Thr Arg Thr Gly His His His His His His 
305                 310                 315         


<210>  18
<211>  292
<212>  PRT
<213>  Artificial

<220>
<223>  IgK-IREM-1-Del3-HA deletion construct


<220>
<221>  SIGNAL
<222>  (1)..(23)
<223>  IgK signal peptide

<220>
<221>  MISC_FEATURE
<222>  (24)..(261)
<223>  IREM-1-Del3 (begins at aa 67)

<220>
<221>  MISC_FEATURE
<222>  (262)..(292)
<223>  HA tag

<400>  18

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ser Thr Ser Gly Ser Glu Gln Glu Val Lys 
            20                  25                  30          


Arg Asp Arg Val Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr 
        35                  40                  45              


Val Thr Met Glu Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys 
    50                  55                  60                  


Gly Ile Glu Lys Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr 
65                  70                  75                  80  


Ile Asp Pro Ala Ser Thr Pro Ala Pro Thr Thr Pro Thr Ser Thr Thr 
                85                  90                  95      


Phe Thr Ala Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu 
            100                 105                 110         


Thr Gly His His Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val 
        115                 120                 125             


Leu Leu Pro Leu Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala 
    130                 135                 140                 


Ser Leu Leu Ala Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly 
145                 150                 155                 160 


Met Ser Pro Glu Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr 
                165                 170                 175     


Ala Asp Leu Thr Leu Gln Leu Ala Gly Thr Ser Pro Arg Lys Ala Thr 
            180                 185                 190         


Thr Lys Leu Ser Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val 
        195                 200                 205             


Thr Met Ala Ser Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr 
    210                 215                 220                 


Leu Gly Ala Glu Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu 
225                 230                 235                 240 


Ser Ser His Leu Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser 
                245                 250                 255     


Thr Ile Ser Arg Pro Ser Leu Glu Gly Pro Arg Phe Glu Gly Lys Pro 
            260                 265                 270         


Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Arg Thr Gly His His 
        275                 280                 285             


His His His His 
    290         


<210>  19
<211>  267
<212>  PRT
<213>  Artificial

<220>
<223>  IgK-IREM-1-Del4-HA deletion construct


<220>
<221>  SIGNAL
<222>  (1)..(23)
<223>  IgK signal peptide

<220>
<221>  MISC_FEATURE
<222>  (24)..(236)
<223>  IREM-1-Del4 (begins at aa 92)

<220>
<221>  MISC_FEATURE
<222>  (237)..(267)
<223>  HA tag

<400>  19

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ser Val Thr Met Glu Asp Leu Met Lys Thr 
            20                  25                  30          


Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys Thr Gly Asn Asp Leu 
        35                  40                  45              


Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala Ser Thr Pro Ala Pro 
    50                  55                  60                  


Thr Thr Pro Thr Ser Thr Thr Phe Thr Ala Pro Val Thr Gln Glu Glu 
65                  70                  75                  80  


Thr Ser Ser Ser Pro Thr Leu Thr Gly His His Leu Asp Asn Arg His 
                85                  90                  95      


Lys Leu Leu Lys Leu Ser Val Leu Leu Pro Leu Ile Phe Thr Ile Leu 
            100                 105                 110         


Leu Leu Leu Leu Val Ala Ala Ser Leu Leu Ala Trp Arg Met Met Lys 
        115                 120                 125             


Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro Glu Gln Val Leu Gln Pro 
    130                 135                 140                 


Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu Thr Leu Gln Leu Ala Gly 
145                 150                 155                 160 


Thr Ser Pro Arg Lys Ala Thr Thr Lys Leu Ser Ser Ala Gln Val Asp 
                165                 170                 175     


Gln Val Glu Val Glu Tyr Val Thr Met Ala Ser Leu Pro Lys Glu Asp 
            180                 185                 190         


Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala Glu Asp Gln Glu Pro Thr 
        195                 200                 205             


Tyr Cys Asn Met Gly His Leu Ser Ser His Leu Pro Gly Arg Gly Pro 
    210                 215                 220                 


Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser Arg Pro Ser Leu Glu Gly 
225                 230                 235                 240 


Pro Arg Phe Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp 
                245                 250                 255     


Ser Thr Arg Thr Gly His His His His His His 
            260                 265         


<210>  20
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  IgK-IREM-1-Del5-HA deletion construct


<220>
<221>  SIGNAL
<222>  (1)..(23)
<223>  IgK signal peptide

<220>
<221>  MISC_FEATURE
<222>  (24)..(211)
<223>  IREM-1-Del4 (begins at aa 117)

<220>
<221>  MISC_FEATURE
<222>  (212)..(242)
<223>  HA tag

<400>  20

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ser Gly Val Thr Val Gln Val Thr Ile Asp 
            20                  25                  30          


Pro Ala Ser Thr Pro Ala Pro Thr Thr Pro Thr Ser Thr Thr Phe Thr 
        35                  40                  45              


Ala Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly 
    50                  55                  60                  


His His Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val Leu Leu 
65                  70                  75                  80  


Pro Leu Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala Ser Leu 
                85                  90                  95      


Leu Ala Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly Met Ser 
            100                 105                 110         


Pro Glu Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr Ala Asp 
        115                 120                 125             


Leu Thr Leu Gln Leu Ala Gly Thr Ser Pro Arg Lys Ala Thr Thr Lys 
    130                 135                 140                 


Leu Ser Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val Thr Met 
145                 150                 155                 160 


Ala Ser Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr Leu Gly 
                165                 170                 175     


Ala Glu Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu Ser Ser 
            180                 185                 190         


His Leu Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser Thr Ile 
        195                 200                 205             


Ser Arg Pro Ser Leu Glu Gly Pro Arg Phe Glu Gly Lys Pro Ile Pro 
    210                 215                 220                 


Asn Pro Leu Leu Gly Leu Asp Ser Thr Arg Thr Gly His His His His 
225                 230                 235                 240 


His His 
        


<210>  21
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  IgK-IREM-1-Del6-HA deletion construct


<220>
<221>  SIGNAL
<222>  (1)..(23)
<223>  IgK signal peptide

<220>
<221>  MISC_FEATURE
<222>  (24)..(188)
<223>  IREM-1-Del6 (begins at aa 140)

<220>
<221>  MISC_FEATURE
<222>  (189)..(219)
<223>  HA tag

<400>  21

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ser Phe Thr Ala Pro Val Thr Gln Glu Glu 
            20                  25                  30          


Thr Ser Ser Ser Pro Thr Leu Thr Gly His His Leu Asp Asn Arg His 
        35                  40                  45              


Lys Leu Leu Lys Leu Ser Val Leu Leu Pro Leu Ile Phe Thr Ile Leu 
    50                  55                  60                  


Leu Leu Leu Leu Val Ala Ala Ser Leu Leu Ala Trp Arg Met Met Lys 
65                  70                  75                  80  


Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro Glu Gln Val Leu Gln Pro 
                85                  90                  95      


Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu Thr Leu Gln Leu Ala Gly 
            100                 105                 110         


Thr Ser Pro Arg Lys Ala Thr Thr Lys Leu Ser Ser Ala Gln Val Asp 
        115                 120                 125             


Gln Val Glu Val Glu Tyr Val Thr Met Ala Ser Leu Pro Lys Glu Asp 
    130                 135                 140                 


Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala Glu Asp Gln Glu Pro Thr 
145                 150                 155                 160 


Tyr Cys Asn Met Gly His Leu Ser Ser His Leu Pro Gly Arg Gly Pro 
                165                 170                 175     


Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser Arg Pro Ser Leu Glu Gly 
            180                 185                 190         


Pro Arg Phe Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp 
        195                 200                 205             


Ser Thr Arg Thr Gly His His His His His His 
    210                 215                 


<210>  22
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  22

Leu Leu Ser Arg Thr Gly Lys Asp Gly Ser Phe Leu Val Arg Ala Ser 
1               5                   10                  15      


Glu Ser Ile Ser Arg Ala Tyr Ala Leu Cys 
            20                  25      


<210>  23
<211>  423
<212>  DNA
<213>  Homo sapiens

<400>  23
attgtcactc aaatcaccgg tccaacaaca gtgaatggct tggagcgggg ctccttgacc     60

gtgcagtgtg tttacagatc aggctgggag acctacttga agtggtggtg tcgaggagct    120

atttggcgtg actgcaagat ccttgttaaa accagtgggt cagagcagga ggtgaagagg    180

gaccgggtgt ccatcaagga caatcagaaa aaccgcacgt tcactgtgac catggaggat    240

ctcatgaaaa ctgatgctga cacttactgg tgtggaattg agaaaactgg aaatgacctt    300

ggggtcacag ttcaagtgac cattgaccca gcgtcgactc ctgcccccac cacgcctacc    360

tccactacgt ttacagcacc agtcacccaa gaagaaacta gcagctcccc aactctgacc    420

ggc                                                                  423


<210>  24
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  24
ggattcacct tcactgatta ctacatgagc                                      30


<210>  25
<211>  57
<212>  DNA
<213>  Mus musculus

<400>  25
tttattagaa acaaagctaa cggttacaca acagagtaca gtgcatctgt gaagggt        57


<210>  26
<211>  42
<212>  DNA
<213>  Mus musculus

<400>  26
gaggactacg gtagtagctg gggttactat gctatggact gc                        42


<210>  27
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  27

Gly Phe Thr Phe Thr Asp Tyr Tyr Met Ser 
1               5                   10  


<210>  28
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  28

Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  29
<211>  28
<212>  PRT
<213>  Mus musculus

<400>  29

Glu Asp Tyr Gly Ser Ser Trp Gly Tyr Tyr Ala Met Asp Cys Glu Asp 
1               5                   10                  15      


Tyr Gly Ser Ser Trp Gly Tyr Tyr Ala Met Asp Cys 
            20                  25              


<210>  30
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  30
aaggccagtc agaatgtgga tactaatgta gcc                                  33


<210>  31
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  31
tcggcatcct accggcacag t                                               21


<210>  32
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  32
cagcaatata acagctttcc tcttaca                                         27


<210>  33
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  33

Lys Ala Ser Gln Asn Val Asp Thr Asn Val Ala 
1               5                   10      


<210>  34
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  34

Ser Ala Ser Tyr Arg His Ser 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  35

Gln Gln Tyr Asn Ser Phe Pro Leu Thr 
1               5                   


<210>  36
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  36
gggtatacct tcacaaacta tccaatgcac                                      30


<210>  37
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  37
tggataaaca cctactctgg agtgccaaca tatgcagatg acttcaaggg a              51


<210>  38
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  38
atggactact atagtaacgg ctttaactac                                      30


<210>  39
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  39

Gly Tyr Thr Phe Thr Asn Tyr Pro Met His 
1               5                   10  


<210>  40
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  40

Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  41
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  41

Met Asp Tyr Tyr Ser Asn Gly Phe Asn Tyr 
1               5                   10  


<210>  42
<211>  48
<212>  DNA
<213>  Mus musculus

<400>  42
agatctagtc agagcattgt acatagtaat ggaaacacct atttagaa                  48


<210>  43
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  43
aaagtttcca accgattttc t                                               21


<210>  44
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  44
tttcaaggtt cacatgttcc gtggacg                                         27


<210>  45
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  45

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  46
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  46

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  47
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  47

Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   


<210>  48
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  48
ggatacgcct tcactaatta cttgatagag                                      30


<210>  49
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  49
gtgattaatc ctggaagtgg tggttcttac tacaatgaga agttcaaggg c              51


<210>  50
<211>  39
<212>  DNA
<213>  Mus musculus

<400>  50
tcggagagta actactcata ttactatgct atggactac                            39


<210>  51
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  51

Gly Tyr Ala Phe Thr Asn Tyr Leu Ile Glu 
1               5                   10  


<210>  52
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  52

Val Ile Asn Pro Gly Ser Gly Gly Ser Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  53
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  53

Ser Glu Ser Asn Tyr Ser Tyr Tyr Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  54
<211>  45
<212>  DNA
<213>  Mus musculus

<400>  54
agagccagcg aaagtgttga taattatggc attagtttta tgaac                     45


<210>  55
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  55
gctgcatcca accgaggatc c                                               21


<210>  56
<211>  26
<212>  DNA
<213>  Mus musculus

<400>  56
cagcaaacta aggaggttcc gtacac                                          26


<210>  57
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  57

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210>  58
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  58

Ala Ala Ser Asn Arg Gly Ser 
1               5           


<210>  59
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  59

Gln Gln Thr Lys Glu Val Pro Tyr Thr 
1               5                   


