                         SEQUENCE LISTING

<110>  Sanofi Pasteur
       MERIAL Limited
 
<120>  Procd de production du virus de la grippe

<130>  PM 0706

<140>  0757884
<141>  2007-09-26

<160>  3     

<170>  PatentIn version 3.3

<210>  1
<211>  564
<212>  PRT
<213>  Avian influenza virus


<220>
<221>  Squence de la protine HA du virus de la grippe aviaire 
       A/chicken/Indonesia/7/03
<222>  (1)..(564)
<223>  Squence en acide amin code par le gne synthtique HA modifi 
       au niveau du site de clivage

<400>  1

Met Glu Lys Ile Val Leu Leu Leu Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Asn Leu Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Asp His Glu Ala Ser 
    130                 135                 140                 


Ser Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Lys Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Ala Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Arg Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Lys Ile Ala Ile Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Ala Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His 
        355                 360                 365             


Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys 
385                 390                 395                 400 


Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu 
                405                 410                 415     


Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp 
            420                 425                 430         


Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg 
        435                 440                 445             


Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val 
    450                 455                 460                 


Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Ile Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asn Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg 
            500                 505                 510         


Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly Thr Tyr Gln Ile 
        515                 520                 525             


Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile Met 
    530                 535                 540                 


Met Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln Cys 
545                 550                 555                 560 


Arg Ile Cys Ile 
                


<210>  2
<211>  7618
<212>  DNA
<213>  Artificial

<220>
<223>  plasmide donneur pJY1394.1

<400>  2
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc     60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga    120

gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc    180

caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc    240

ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag    300

cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa    360

agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac    420

cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcc cattcgccat tcaggctgcg    480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg    540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg    600

taaaacgacg gccagtgaat tgtaatacga ctcactatag ggcgaattgg gtgacccttt    660

acaagaataa aagaagaaac aactgtgaaa tagtttataa atgtaattcg tatgcagaaa    720

acgataatat attttggtat gagaaatcta aaggagacat agtttgtata gacatgcgct    780

cttccgatga gatattcgat gcttttctaa tgtatcatat agctacaaga tatgcctatc    840

atgatgatga tatatatcta caaatagtgt tatattattc taataatcaa aatgttatat    900

cttatattac gaaaaataaa tacgttaagt atataagaaa taaaactaga gacgatattc    960

ataaagtaaa aatattagct ctagaagact ttacaacgga agaaatatat tgttggatta   1020

gtaatatata acagcgtagc tgcacggttt tgatcatttt ccaacaatat aaaccaatga   1080

aggaggacga ctcatcaaac ataaataaca ttcacggaaa atattcagta tcagatttat   1140

cacaagatga ttatgttatt gaatgtatag acggatcttt tgattcgatc aagtatagag   1200

atataaaggt tataataatg aagaataacg gttacgttaa ttgtagtaaa ttatgtaaaa   1260

tgcggaataa atacttttct agatggttgc gtctttctac ttctaaagca ttattagaca   1320

tttacaataa taagtcagta gataatgcta ttgttaaagt ctatggtaaa ggtaagaaac   1380

ttattataac aggattttat ctcaaacaaa atatgatacg ttatgttatt gagtggatag   1440

gggatgattt tacaaacgat atatacaaaa tgattaattt ctataatgcg ttattcggta   1500

acgatgaatt aaaaatagta tcctgtgaaa acactctatg cccgtttata gaacttggta   1560

gatgctatta tggtaaaaaa tgtaagtata tacacggaga tcaatgtgat atctgtggtc   1620

tatatatact acaccctacc gatattaacc aacgagtttc tcacaagaaa acttgtttag   1680

tagatagaga ttctttgatt gtgtttaaaa gaagtaccag taaaaagtgt ggcatatgca   1740

tagaagaaat aaacaaaaaa catatttccg aacagtattt tggaattctc ccaagttgta   1800

aacatatttt ttgcctatca tgtataagac gttgggcaga tactaccaga aatacagata   1860

ctgaaaatac gtgtcctgaa tgtagaatag tttttccttt cataataccc agtaggtatt   1920

ggatagataa taaatatgat aaaaaaatat tatataatag atataagaaa atgattttta   1980

caaaaatacc tataagaaca ataaaaatat aattacattt acggaaaata gctggtttta   2040

gtttaccaac ttagagtaat tatcatattg aatctatatt gctaattagc taataaaaac   2100

ccgggttaat taattagtca tcaggcaggg cgagaacgag actatctgct cgttaattaa   2160

ttagagcttc tttattctat acttaaaaag tgaaaataaa tacaaaggtt cttgagggtt   2220

gtgttaaatt gaaagcgaga aataatcata aattatttca ttatcgcgat atccgttaag   2280

tttgtatcgt aatggagaaa atcgtgctgc tgctggccat cgtgagcctg gtgaaaagcg   2340

atcagatctg catcggctac cacgccaaca acagcacaga gcaagtggac acaatcatgg   2400

aaaagaacgt gaccgtgaca cacgcccagg acatcctgga aaagacacac aacgggaagc   2460

tgtgcgatct ggatggagtg aagcctctga tcctgagaga ttgcagcgtg gccggatggc   2520

tgctggggaa cccaatgtgc gacgaattca tcaacgtgcc cgaatggagc tacatcgtgg   2580

agaaggccaa cccagccaac gacctgtgct acccagggaa cctgaacgac tacgaagaac   2640

tgaaacacct gctgagcaga atcaaccact ttgagaaaat ccagatcatc cccaaaagca   2700

gctggtccga tcacgaagcc agcagcggag tgagcagcgc ctgcccatac cagggaaagt   2760

ccagcttttt tagaaacgtg gtgtggctga tcaaaaagaa cagcgcctac ccaacaatca   2820

agagaagcta caacaacacc aaccaggaag atctgctggt gctgtggggg atccaccacc   2880

ctaacgatgc cgccgagcag acaaggctgt accagaaccc aaccacctac atctccgtgg   2940

ggacaagcac actgaaccag agactggtgc caaaaatcgc catcagatcc aaagtgaacg   3000

ggcagagcgg aagaatggag ttcttctgga caatcctgaa acccaacgat gccatcaact   3060

tcgagagcaa cggaaacttc atcgccccag aatacgccta caaaatcgtg aagaaagggg   3120

acagcgccat catgaaaagc gaactggaat acggcaactg caacaccaag tgccagaccc   3180

caatgggggc catcaacagc agcatgccat tccacaacat ccaccctctg accatcgggg   3240

aatgccccaa atacgtgaaa agcaacagac tggtgctggc caccgggctg agaaacagcc   3300

ctcagagaga gaccagagga ctgtttggag ccatcgccgg ctttatcgag ggaggatggc   3360

agggaatggt ggatggctgg tacggatacc accacagcaa cgagcagggg agcggatacg   3420

ccgccgacaa agaatccacc cagaaggcca tcgacggcgt gaccaacaaa gtgaacagca   3480

tcatcgacaa aatgaacacc cagtttgagg ccgtgggaag ggagtttaac aacctggaaa   3540

ggagaatcga gaacctgaac aagaagatgg aggacggatt cctggatgtg tggacctaca   3600

acgccgaact gctggtgctg atggaaaacg agagaaccct ggactttcac gacagcaacg   3660

tgaagaacct gtacgacaaa gtgaggctgc agctgaggga taacgccaag gagctgggca   3720

acggctgctt cgagttctac cacaaatgcg ataacgaatg catggaaagc atcagaaacg   3780

gaacctacaa ctacccccag tacagcgaag aagccagact gaaaagagaa gaaatctccg   3840

gagtgaaact ggaatccatc ggaacctacc agatcctgag catctacagc acagtggcct   3900

cctccctggc cctggccatc atgatggccg gactgagcct gtggatgtgc tccaacggaa   3960

gcctgcagtg cagaatctgc atctgactcg agtttttatt gactagttaa tcataagata   4020

aataatatac agcattgtaa ccatcgtcat ccgttatacg gggaataata ttaccataca   4080

gtattattaa attttcttac gaagaatata gatcggtatt tatcgttagt ttattttaca   4140

tttattaatt aaacatgtct actattacct gttatggaaa tgacaaattt agttatataa   4200

tttatgataa aattaagata ataataatga aatcaaataa ttatgtaaat gctactagat   4260

tatgtgaatt acgaggaaga aagtttacga actggaaaaa attaagtgaa tctaaaatat   4320

tagtcgataa tgtaaaaaaa ataaatgata aaactaacca gttaaaaacg gatatgatta   4380

tatacgttaa ggatattgat cataaaggaa gagatacttg cggttactat gtacaccaag   4440

atctggtatc ttctatatca aattggatat ctccgttatt cgccgttaag gtaaataaaa   4500

ttattaacta ttatatatgt aatgaatatg atatacgact tagcgaaatg gaatctgata   4560

tgacagaagt aatagatgta gttgataaat tagtaggagg atacaatgat gaaatagcag   4620

aaataatata tttgtttaat aaatttatag aaaaatatat tgctaacata tcgttatcaa   4680

ctgaattatc tagtatatta aataatttta taaattttaa taaaaaatac aataacgaca   4740

taaaagatat taaatcttta attcttgatc tgaaaaacac atctataaaa ctagataaaa   4800

agttattcga taaagataat aatgaatcga acgatgaaaa attggaaaca gaagttgata   4860

agctaatttt tttcatctaa atagtattat tttattgaag tacgaagttt tacgttagat   4920

aaataataaa ggtcgatttt tattttgtta aatatcaaat atgtcattat ctgataaaga   4980

tacaaaaaca cacggtgatt atcaaccatc taacgaacag atattacaaa aaatacgtcg   5040

gactatggaa aacgaagctg atagcctcaa tagaagaagc attaaagaaa ttgttgtaga   5100

tgttatgaag aattgggatc atcctctcaa cgaagaaata gataaagttc taaactggaa   5160

aaatgataca ttaaacgatt tagatcatct aaatacagat gataatatta aggaaatcat   5220

acaatgtctg attagagaat ttgcgtttaa aaagatcaat tctattatgt atagttatgc   5280

tatggtaaaa ctcaattcag ataacgaaac attgaaagat aaaattaagg attattttat   5340

agaaactatt cttaaagaca aacgtggtta taaacaaaag ccattaccct agagcggccg   5400

ccaccgcggt ggagctccag cttttgttcc ctttagtgag ggttaatttc gagcttggcg   5460

taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac   5520

atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca   5580

ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat   5640

taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc   5700

tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca   5760

aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca   5820

aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg   5880

ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg   5940

acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt   6000

ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt   6060

tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc   6120

tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt   6180

gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt   6240

agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc   6300

tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa   6360

agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt   6420

tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct   6480

acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta   6540

tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa   6600

agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc   6660

tcagcgatct gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact   6720

acgatacggg agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc   6780

tcaccggctc cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt   6840

ggtcctgcaa ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta   6900

agtagttcgc cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg   6960

tcacgctcgt cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt   7020

acatgatccc ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc   7080

agaagtaagt tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt   7140

actgtcatgc catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc   7200

tgagaatagt gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc   7260

gcgccacata gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa   7320

ctctcaagga tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac   7380

tgatcttcag catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa   7440

aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt   7500

tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa   7560

tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccac     7618


<210>  3
<211>  4885
<212>  DNA
<213>  Artificial

<220>
<223>  squence nuclotidique de l'insert du plasmide pJY1394.1


<220>
<221>  squence partielle du plasmide de clonage comprenant la squence 
       du primer M13F
<222>  (1)..(53)

<220>
<221>  squence du " bras gauche " flanquant le locus d'insertion F8 
       dans le gnome du vecteur TROVAC fowlpox.
<222>  (54)..(1483)

<220>
<221>  squence de liaison entre le bras gauche et le promoteur H6
<222>  (1484)..(1568)

<220>
<221>  squence du promoteur H6 du virus de la vaccine
<222>  (1569)..(1692)

<220>
<221>  squence du gne synthtique modifi HA de la souche 
       A/chicken/Indonesia/7/03
<222>  (1693)..(3387)

<220>
<221>  squence de liaison entre le gne HA et le bras droit
<222>  (3388)..(3414)
<223>  squence comprenant une squence TTTTTAT d'arrt de transcription
       des gnes prcoces du fowlpox

<220>
<221>  squence du " bras droit " flanquant le locus d'insertion F8 dans
       le gnome du vecteur TROVAC fowlpox
<222>  (3415)..(4790)

<220>
<221>  squence partielle du plasmide de clonage comprenant la squence 
       du primer M13R
<222>  (4791)..(4885)

<400>  3
gtaaaacgac ggccagtgaa ttgtaatacg actcactata gggcgaattg ggtgaccctt     60

tacaagaata aaagaagaaa caactgtgaa atagtttata aatgtaattc gtatgcagaa    120

aacgataata tattttggta tgagaaatct aaaggagaca tagtttgtat agacatgcgc    180

tcttccgatg agatattcga tgcttttcta atgtatcata tagctacaag atatgcctat    240

catgatgatg atatatatct acaaatagtg ttatattatt ctaataatca aaatgttata    300

tcttatatta cgaaaaataa atacgttaag tatataagaa ataaaactag agacgatatt    360

cataaagtaa aaatattagc tctagaagac tttacaacgg aagaaatata ttgttggatt    420

agtaatatat aacagcgtag ctgcacggtt ttgatcattt tccaacaata taaaccaatg    480

aaggaggacg actcatcaaa cataaataac attcacggaa aatattcagt atcagattta    540

tcacaagatg attatgttat tgaatgtata gacggatctt ttgattcgat caagtataga    600

gatataaagg ttataataat gaagaataac ggttacgtta attgtagtaa attatgtaaa    660

atgcggaata aatacttttc tagatggttg cgtctttcta cttctaaagc attattagac    720

atttacaata ataagtcagt agataatgct attgttaaag tctatggtaa aggtaagaaa    780

cttattataa caggatttta tctcaaacaa aatatgatac gttatgttat tgagtggata    840

ggggatgatt ttacaaacga tatatacaaa atgattaatt tctataatgc gttattcggt    900

aacgatgaat taaaaatagt atcctgtgaa aacactctat gcccgtttat agaacttggt    960

agatgctatt atggtaaaaa atgtaagtat atacacggag atcaatgtga tatctgtggt   1020

ctatatatac tacaccctac cgatattaac caacgagttt ctcacaagaa aacttgttta   1080

gtagatagag attctttgat tgtgtttaaa agaagtacca gtaaaaagtg tggcatatgc   1140

atagaagaaa taaacaaaaa acatatttcc gaacagtatt ttggaattct cccaagttgt   1200

aaacatattt tttgcctatc atgtataaga cgttgggcag atactaccag aaatacagat   1260

actgaaaata cgtgtcctga atgtagaata gtttttcctt tcataatacc cagtaggtat   1320

tggatagata ataaatatga taaaaaaata ttatataata gatataagaa aatgattttt   1380

acaaaaatac ctataagaac aataaaaata taattacatt tacggaaaat agctggtttt   1440

agtttaccaa cttagagtaa ttatcatatt gaatctatat tgctaattag ctaataaaaa   1500

cccgggttaa ttaattagtc atcaggcagg gcgagaacga gactatctgc tcgttaatta   1560

attagagctt ctttattcta tacttaaaaa gtgaaaataa atacaaaggt tcttgagggt   1620

tgtgttaaat tgaaagcgag aaataatcat aaattatttc attatcgcga tatccgttaa   1680

gtttgtatcg taatggagaa aatcgtgctg ctgctggcca tcgtgagcct ggtgaaaagc   1740

gatcagatct gcatcggcta ccacgccaac aacagcacag agcaagtgga cacaatcatg   1800

gaaaagaacg tgaccgtgac acacgcccag gacatcctgg aaaagacaca caacgggaag   1860

ctgtgcgatc tggatggagt gaagcctctg atcctgagag attgcagcgt ggccggatgg   1920

ctgctgggga acccaatgtg cgacgaattc atcaacgtgc ccgaatggag ctacatcgtg   1980

gagaaggcca acccagccaa cgacctgtgc tacccaggga acctgaacga ctacgaagaa   2040

ctgaaacacc tgctgagcag aatcaaccac tttgagaaaa tccagatcat ccccaaaagc   2100

agctggtccg atcacgaagc cagcagcgga gtgagcagcg cctgcccata ccagggaaag   2160

tccagctttt ttagaaacgt ggtgtggctg atcaaaaaga acagcgccta cccaacaatc   2220

aagagaagct acaacaacac caaccaggaa gatctgctgg tgctgtgggg gatccaccac   2280

cctaacgatg ccgccgagca gacaaggctg taccagaacc caaccaccta catctccgtg   2340

gggacaagca cactgaacca gagactggtg ccaaaaatcg ccatcagatc caaagtgaac   2400

gggcagagcg gaagaatgga gttcttctgg acaatcctga aacccaacga tgccatcaac   2460

ttcgagagca acggaaactt catcgcccca gaatacgcct acaaaatcgt gaagaaaggg   2520

gacagcgcca tcatgaaaag cgaactggaa tacggcaact gcaacaccaa gtgccagacc   2580

ccaatggggg ccatcaacag cagcatgcca ttccacaaca tccaccctct gaccatcggg   2640

gaatgcccca aatacgtgaa aagcaacaga ctggtgctgg ccaccgggct gagaaacagc   2700

cctcagagag agaccagagg actgtttgga gccatcgccg gctttatcga gggaggatgg   2760

cagggaatgg tggatggctg gtacggatac caccacagca acgagcaggg gagcggatac   2820

gccgccgaca aagaatccac ccagaaggcc atcgacggcg tgaccaacaa agtgaacagc   2880

atcatcgaca aaatgaacac ccagtttgag gccgtgggaa gggagtttaa caacctggaa   2940

aggagaatcg agaacctgaa caagaagatg gaggacggat tcctggatgt gtggacctac   3000

aacgccgaac tgctggtgct gatggaaaac gagagaaccc tggactttca cgacagcaac   3060

gtgaagaacc tgtacgacaa agtgaggctg cagctgaggg ataacgccaa ggagctgggc   3120

aacggctgct tcgagttcta ccacaaatgc gataacgaat gcatggaaag catcagaaac   3180

ggaacctaca actaccccca gtacagcgaa gaagccagac tgaaaagaga agaaatctcc   3240

ggagtgaaac tggaatccat cggaacctac cagatcctga gcatctacag cacagtggcc   3300

tcctccctgg ccctggccat catgatggcc ggactgagcc tgtggatgtg ctccaacgga   3360

agcctgcagt gcagaatctg catctgactc gagtttttat tgactagtta atcataagat   3420

aaataatata cagcattgta accatcgtca tccgttatac ggggaataat attaccatac   3480

agtattatta aattttctta cgaagaatat agatcggtat ttatcgttag tttattttac   3540

atttattaat taaacatgtc tactattacc tgttatggaa atgacaaatt tagttatata   3600

atttatgata aaattaagat aataataatg aaatcaaata attatgtaaa tgctactaga   3660

ttatgtgaat tacgaggaag aaagtttacg aactggaaaa aattaagtga atctaaaata   3720

ttagtcgata atgtaaaaaa aataaatgat aaaactaacc agttaaaaac ggatatgatt   3780

atatacgtta aggatattga tcataaagga agagatactt gcggttacta tgtacaccaa   3840

gatctggtat cttctatatc aaattggata tctccgttat tcgccgttaa ggtaaataaa   3900

attattaact attatatatg taatgaatat gatatacgac ttagcgaaat ggaatctgat   3960

atgacagaag taatagatgt agttgataaa ttagtaggag gatacaatga tgaaatagca   4020

gaaataatat atttgtttaa taaatttata gaaaaatata ttgctaacat atcgttatca   4080

actgaattat ctagtatatt aaataatttt ataaatttta ataaaaaata caataacgac   4140

ataaaagata ttaaatcttt aattcttgat ctgaaaaaca catctataaa actagataaa   4200

aagttattcg ataaagataa taatgaatcg aacgatgaaa aattggaaac agaagttgat   4260

aagctaattt ttttcatcta aatagtatta ttttattgaa gtacgaagtt ttacgttaga   4320

taaataataa aggtcgattt ttattttgtt aaatatcaaa tatgtcatta tctgataaag   4380

atacaaaaac acacggtgat tatcaaccat ctaacgaaca gatattacaa aaaatacgtc   4440

ggactatgga aaacgaagct gatagcctca atagaagaag cattaaagaa attgttgtag   4500

atgttatgaa gaattgggat catcctctca acgaagaaat agataaagtt ctaaactgga   4560

aaaatgatac attaaacgat ttagatcatc taaatacaga tgataatatt aaggaaatca   4620

tacaatgtct gattagagaa tttgcgttta aaaagatcaa ttctattatg tatagttatg   4680

ctatggtaaa actcaattca gataacgaaa cattgaaaga taaaattaag gattatttta   4740

tagaaactat tcttaaagac aaacgtggtt ataaacaaaa gccattaccc tagagcggcc   4800

gccaccgcgg tggagctcca gcttttgttc cctttagtga gggttaattt cgagcttggc   4860

gtaatcatgg tcatagctgt ttcct                                         4885


