                         SEQUENCE LISTING

<110>  Bristol-Myers Squibb Company
       Gordon, David
       Blat, Yuval
       Nayeem, Akbar
       Kirby, Mark S.
       He, Bin
 
<120>  11 BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1

<130>  11019 PCT

<150>  60/978,231
<151>  2007-10-08

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  879
<212>  DNA
<213>  Homo sapiens

<400>  1
atggctttta tgaaaaaata tctcctcccc attctggggc tcttcatggc ctactactac       60

tattctgcaa acgaggaatt cagaccagag atgctccaag gaaagaaagt gattgtcaca      120

ggggccagca aagggatcgg aagagagatg gcttatcatc tggcgaagat gggagcccat      180

gtggtggtga cagcgaggtc aaaagaaact ctacagaagg tggtatccca ctgcctggag      240

cttggagcag cctcagcaca ctacattgct ggcaccatgg aagacatgac cttcgcagag      300

caatttgttg cccaagcagg aaagctcatg ggaggactag acatgctcat tctcaaccac      360

atcaccaaca cttctttgaa tctttttcat gatgatattc accatgtgcg caaaagcatg      420

gaagtcaact tcctcagtta cgtggtcctg actgtagctg ccttgcccat gctgaagcag      480

agcaatggaa gcattgttgt cgtctcctct ctggctggga aagtggctta tccaatggtt      540

gctgcctatt ctgcaagcaa gtttgctttg gatgggttct tctcctccat cagaaaggaa      600

tattcagtgt ccagggtcaa tgtatcaatc actctctgtg ttcttggcct catagacaca      660

gaaacagcca tgaaggcagt ttctgggata gtccatatgc aagcagctcc aaaggaggaa      720

tgtgccctgg agatcatcaa agggggagct ctgcgccaag aagaagtgta ttatgacagc      780

tcactctgga ccactcttct gatcagaaat ccatgcagga agatcctgga atttctctac      840

tcaacgagct ataatatgga cagattcata aacaagtag                             879


<210>  2
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Phe Met Lys Lys Tyr Leu Leu Pro Ile Leu Gly Leu Phe Met 
1               5                   10                  15      


Ala Tyr Tyr Tyr Tyr Ser Ala Asn Glu Glu Phe Arg Pro Glu Met Leu 
            20                  25                  30          


Gln Gly Lys Lys Val Ile Val Thr Gly Ala Ser Lys Gly Ile Gly Arg 
        35                  40                  45              


Glu Met Ala Tyr His Leu Ala Lys Met Gly Ala His Val Val Val Thr 
    50                  55                  60                  


Ala Arg Ser Lys Glu Thr Leu Gln Lys Val Val Ser His Cys Leu Glu 
65                  70                  75                  80  


Leu Gly Ala Ala Ser Ala His Tyr Ile Ala Gly Thr Met Glu Asp Met 
                85                  90                  95      


Thr Phe Ala Glu Gln Phe Val Ala Gln Ala Gly Lys Leu Met Gly Gly 
            100                 105                 110         


Leu Asp Met Leu Ile Leu Asn His Ile Thr Asn Thr Ser Leu Asn Leu 
        115                 120                 125             


Phe His Asp Asp Ile His His Val Arg Lys Ser Met Glu Val Asn Phe 
    130                 135                 140                 


Leu Ser Tyr Val Val Leu Thr Val Ala Ala Leu Pro Met Leu Lys Gln 
145                 150                 155                 160 


Ser Asn Gly Ser Ile Val Val Val Ser Ser Leu Ala Gly Lys Val Ala 
                165                 170                 175     


Tyr Pro Met Val Ala Ala Tyr Ser Ala Ser Lys Phe Ala Leu Asp Gly 
            180                 185                 190         


Phe Phe Ser Ser Ile Arg Lys Glu Tyr Ser Val Ser Arg Val Asn Val 
        195                 200                 205             


Ser Ile Thr Leu Cys Val Leu Gly Leu Ile Asp Thr Glu Thr Ala Met 
    210                 215                 220                 


Lys Ala Val Ser Gly Ile Val His Met Gln Ala Ala Pro Lys Glu Glu 
225                 230                 235                 240 


Cys Ala Leu Glu Ile Ile Lys Gly Gly Ala Leu Arg Gln Glu Glu Val 
                245                 250                 255     


Tyr Tyr Asp Ser Ser Leu Trp Thr Thr Leu Leu Ile Arg Asn Pro Cys 
            260                 265                 270         


Arg Lys Ile Leu Glu Phe Leu Tyr Ser Thr Ser Tyr Asn Met Asp Arg 
        275                 280                 285             


Phe Ile Asn Lys 
    290         


<210>  3
<211>  879
<212>  DNA
<213>  Mus musculus

<400>  3
atggcagtta tgaaaaatta cctcctcccg atcctggtgc tcttcctggc ctactactac       60

tattctacaa atgaagagtt cagaccagaa atgctccagg gaaagaaagt gattgtcact      120

ggggccagca aagggattgg aagagaaatg gcatatcatc tgtcaaaaat gggagcccat      180

gtggtattga ctgccaggtc ggaggaaggt ctccagaagg tagtgtctcg ctgccttgaa      240

ctcggagcag cctctgctca ctacattgct ggcactatgg aagacatgac atttgcggag      300

caatttattg tcaaggcggg aaagctcatg ggcggactgg acatgcttat tctaaaccac      360

atcactcaga cctcgctgtc tctcttccat gacgacatcc actctgtgcg aagagtcatg      420

gaggtcaact tcctcagcta cgtggtcatg agcacagccg ccttgcccat gctgaagcag      480

agcaatggca gcattgccgt catctcctcc ttggctggga aaatgaccca gcctatgatt      540

gctccctact ctgcaagcaa gtttgctctg gatgggttct tttccaccat tagaacagaa      600

ctctacataa ccaaggtcaa cgtgtccatc actctctgtg tccttggcct catagacaca      660

gaaacagcta tgaaggaaat ctctgggata attaacgccc aagcttctcc caaggaggag      720

tgcgccctgg agatcatcaa aggcacagct ctacgcaaaa gcgaggtgta ctatgacaaa      780

tcgcctttga ctccaatcct gcttgggaac ccaggaagga agatcatgga atttttttca      840

ttacgatatt ataataagga catgtttgta agtaactag                             879


<210>  4
<211>  292
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Val Met Lys Asn Tyr Leu Leu Pro Ile Leu Val Leu Phe Leu 
1               5                   10                  15      


Ala Tyr Tyr Tyr Tyr Ser Thr Asn Glu Glu Phe Arg Pro Glu Met Leu 
            20                  25                  30          


Gln Gly Lys Lys Val Ile Val Thr Gly Ala Ser Lys Gly Ile Gly Arg 
        35                  40                  45              


Glu Met Ala Tyr His Leu Ser Lys Met Gly Ala His Val Val Leu Thr 
    50                  55                  60                  


Ala Arg Ser Glu Glu Gly Leu Gln Lys Val Val Ser Arg Cys Leu Glu 
65                  70                  75                  80  


Leu Gly Ala Ala Ser Ala His Tyr Ile Ala Gly Thr Met Glu Asp Met 
                85                  90                  95      


Thr Phe Ala Glu Gln Phe Ile Val Lys Ala Gly Lys Leu Met Gly Gly 
            100                 105                 110         


Leu Asp Met Leu Ile Leu Asn His Ile Thr Gln Thr Ser Leu Ser Leu 
        115                 120                 125             


Phe His Asp Asp Ile His Ser Val Arg Arg Val Met Glu Val Asn Phe 
    130                 135                 140                 


Leu Ser Tyr Val Val Met Ser Thr Ala Ala Leu Pro Met Leu Lys Gln 
145                 150                 155                 160 


Ser Asn Gly Ser Ile Ala Val Ile Ser Ser Leu Ala Gly Lys Met Thr 
                165                 170                 175     


Gln Pro Met Ile Ala Pro Tyr Ser Ala Ser Lys Phe Ala Leu Asp Gly 
            180                 185                 190         


Phe Phe Ser Thr Ile Arg Thr Glu Leu Tyr Ile Thr Lys Val Asn Val 
        195                 200                 205             


Ser Ile Thr Leu Cys Val Leu Gly Leu Ile Asp Thr Glu Thr Ala Met 
    210                 215                 220                 


Lys Glu Ile Ser Gly Ile Ile Asn Ala Gln Ala Ser Pro Lys Glu Glu 
225                 230                 235                 240 


Cys Ala Leu Glu Ile Ile Lys Gly Thr Ala Leu Arg Lys Ser Glu Val 
                245                 250                 255     


Tyr Tyr Asp Lys Ser Pro Leu Thr Pro Ile Leu Leu Gly Asn Pro Gly 
            260                 265                 270         


Arg Lys Ile Met Glu Phe Phe Ser Leu Arg Tyr Tyr Asn Lys Asp Met 
        275                 280                 285             


Phe Val Ser Asn 
    290         


<210>  5
<211>  879
<212>  DNA
<213>  Mus musculus

<400>  5
atggcagtta tgaaaaatta cctcctcccg atcctggtgc tcttcctggc ctactactac       60

tattctacaa atgaagagtt cagaccagaa atgctccagg gaaagaaagt gattgtcact      120

ggggccagca aagggattgg aagagaaatg gcatatcatc tgtcaaaaat gggagcccat      180

gtggtattga ctgccaggtc ggaggaaggt ctccagaagg tagtgtctcg ctgccttgaa      240

ctcggagcag cctctgctca ctacattgct ggcactatgg aagacatgac atttgcggag      300

caatttattg tcaaggcggg aaagctcatg ggcggactgg acatgcttat tctaaaccac      360

atcactcaga cctcgctgtc tctcttccat gacgacatcc actctgtgcg aagagtcatg      420

gaggtcaact tcctcagcta cgtggtcatg agcacagccg ccttgcccat gctgaagcag      480

agcaatggca gcattgccgt catctcctcc ttggctggga aaatgaccta tcctatgatt      540

gctccctact ctgcaagcaa gtttgctctg gatgggttct tttccaccat tagaacagaa      600

ctctacataa ccaaggtcaa cgtgtccatc actctctgtg tccttggcct catagacaca      660

gaaacagcta tgaaggaaat ctctgggata attaacgccc aagcttctcc caaggaggag      720

tgcgccctgg agatcatcaa aggcacagct ctacgcaaaa gcgaggtgta ctatgacaaa      780

tcgcctttga ctccaatcct gcttgggaac ccaggaagga agatcatgga atttttttca      840

ttacgatatt ataataagga catgtttgta agtaactag                             879


<210>  6
<211>  292
<212>  PRT
<213>  Mus musculus

<400>  6

Met Ala Val Met Lys Asn Tyr Leu Leu Pro Ile Leu Val Leu Phe Leu 
1               5                   10                  15      


Ala Tyr Tyr Tyr Tyr Ser Thr Asn Glu Glu Phe Arg Pro Glu Met Leu 
            20                  25                  30          


Gln Gly Lys Lys Val Ile Val Thr Gly Ala Ser Lys Gly Ile Gly Arg 
        35                  40                  45              


Glu Met Ala Tyr His Leu Ser Lys Met Gly Ala His Val Val Leu Thr 
    50                  55                  60                  


Ala Arg Ser Glu Glu Gly Leu Gln Lys Val Val Ser Arg Cys Leu Glu 
65                  70                  75                  80  


Leu Gly Ala Ala Ser Ala His Tyr Ile Ala Gly Thr Met Glu Asp Met 
                85                  90                  95      


Thr Phe Ala Glu Gln Phe Ile Val Lys Ala Gly Lys Leu Met Gly Gly 
            100                 105                 110         


Leu Asp Met Leu Ile Leu Asn His Ile Thr Gln Thr Ser Leu Ser Leu 
        115                 120                 125             


Phe His Asp Asp Ile His Ser Val Arg Arg Val Met Glu Val Asn Phe 
    130                 135                 140                 


Leu Ser Tyr Val Val Met Ser Thr Ala Ala Leu Pro Met Leu Lys Gln 
145                 150                 155                 160 


Ser Asn Gly Ser Ile Ala Val Ile Ser Ser Leu Ala Gly Lys Met Thr 
                165                 170                 175     


Tyr Pro Met Ile Ala Pro Tyr Ser Ala Ser Lys Phe Ala Leu Asp Gly 
            180                 185                 190         


Phe Phe Ser Thr Ile Arg Thr Glu Leu Tyr Ile Thr Lys Val Asn Val 
        195                 200                 205             


Ser Ile Thr Leu Cys Val Leu Gly Leu Ile Asp Thr Glu Thr Ala Met 
    210                 215                 220                 


Lys Glu Ile Ser Gly Ile Ile Asn Ala Gln Ala Ser Pro Lys Glu Glu 
225                 230                 235                 240 


Cys Ala Leu Glu Ile Ile Lys Gly Thr Ala Leu Arg Lys Ser Glu Val 
                245                 250                 255     


Tyr Tyr Asp Lys Ser Pro Leu Thr Pro Ile Leu Leu Gly Asn Pro Gly 
            260                 265                 270         


Arg Lys Ile Met Glu Phe Phe Ser Leu Arg Tyr Tyr Asn Lys Asp Met 
        275                 280                 285             


Phe Val Ser Asn 
    290         


<210>  7
<211>  879
<212>  DNA
<213>  Mus musculus

<400>  7
atggcagtta tgaaaaatta cctcctcccg atcctggtgc tcttcctggc ctactactac       60

tattctacaa atgaagagtt cagaccagaa atgctccagg gaaagaaagt gattgtcact      120

ggggccagca aagggattgg aagagaaatg gcatatcatc tgtcaaaaat gggagcccat      180

gtggtattga ctgccaggtc ggaggaaggt ctccagaagg tagtgtctcg ctgccttgaa      240

ctcggagcag cctctgctca ctacattgct ggcactatgg aagacatgac atttgcggag      300

caatttattg tcaaggcggg aaagctcatg ggcggactgg acatgcttat tctaaaccac      360

atcactcaga cctcgctgtc tctcttccat gacgacatcc actctgtgcg aagagtcatg      420

gaggtcaact tcctcagcta cgtggtcatg agcacagccg ccttgcccat gctgaagcag      480

agcaatggca gcattgccgt catctcctcc ttggctggga aaatgaccta tcctatgatt      540

gctccctact ctgcaagcaa gtttgctctg gatgggttct tttccaccat tagaacagaa      600

ctctacataa ccaaggtcaa cgtgtccatc actctctgtg tccttggcct catagacaca      660

gaaacagcta tgaaggaaat ctctgggata gttaacatgc aagcttctcc caaggaggag      720

tgcgccctgg agatcatcaa aggcacagct ctacgcaaaa gcgaggtgta ctatgacaaa      780

tcgcctttga ctccaatcct gcttgggaac ccaggaagga agatcatgga atttttttca      840

ttacgatatt ataataagga catgtttgta agtaactag                             879


<210>  8
<211>  292
<212>  PRT
<213>  Mus musculus

<400>  8

Met Ala Val Met Lys Asn Tyr Leu Leu Pro Ile Leu Val Leu Phe Leu 
1               5                   10                  15      


Ala Tyr Tyr Tyr Tyr Ser Thr Asn Glu Glu Phe Arg Pro Glu Met Leu 
            20                  25                  30          


Gln Gly Lys Lys Val Ile Val Thr Gly Ala Ser Lys Gly Ile Gly Arg 
        35                  40                  45              


Glu Met Ala Tyr His Leu Ser Lys Met Gly Ala His Val Val Leu Thr 
    50                  55                  60                  


Ala Arg Ser Glu Glu Gly Leu Gln Lys Val Val Ser Arg Cys Leu Glu 
65                  70                  75                  80  


Leu Gly Ala Ala Ser Ala His Tyr Ile Ala Gly Thr Met Glu Asp Met 
                85                  90                  95      


Thr Phe Ala Glu Gln Phe Ile Val Lys Ala Gly Lys Leu Met Gly Gly 
            100                 105                 110         


Leu Asp Met Leu Ile Leu Asn His Ile Thr Gln Thr Ser Leu Ser Leu 
        115                 120                 125             


Phe His Asp Asp Ile His Ser Val Arg Arg Val Met Glu Val Asn Phe 
    130                 135                 140                 


Leu Ser Tyr Val Val Met Ser Thr Ala Ala Leu Pro Met Leu Lys Gln 
145                 150                 155                 160 


Ser Asn Gly Ser Ile Ala Val Ile Ser Ser Leu Ala Gly Lys Met Thr 
                165                 170                 175     


Gln Pro Met Ile Ala Pro Tyr Ser Ala Ser Lys Phe Ala Leu Asp Gly 
            180                 185                 190         


Phe Phe Ser Thr Ile Arg Thr Glu Leu Tyr Ile Thr Lys Val Asn Val 
        195                 200                 205             


Ser Ile Thr Leu Cys Val Leu Gly Leu Ile Asp Thr Glu Thr Ala Met 
    210                 215                 220                 


Lys Glu Ile Ser Gly Ile Val Asn Ala Gln Ala Ser Pro Lys Glu Glu 
225                 230                 235                 240 


Cys Ala Leu Glu Ile Ile Lys Gly Thr Ala Leu Arg Lys Ser Glu Val 
                245                 250                 255     


Tyr Tyr Asp Lys Ser Pro Leu Thr Pro Ile Leu Leu Gly Asn Pro Gly 
            260                 265                 270         


Arg Lys Ile Met Glu Phe Phe Ser Leu Arg Tyr Tyr Asn Lys Asp Met 
        275                 280                 285             


Phe Val Ser Asn 
    290         


<210>  9
<211>  671
<212>  DNA
<213>  Mus musculus

<400>  9
gtctccagaa ggtagtgtct cgctgccttg aactcggagc agcctctgct cactacattg       60

ctggcactat ggaagacatg acatttgcgg agcaatttat tgtcaaggcg ggaaagctca      120

tgggcggact ggacatgctt attctaaacc acatcactca gacctcgctg tctctcttcc      180

atgacgacat ccactctgtg cgaagagtca tggaggtcaa cttcctcagc tacgtggtca      240

tgagcacagc cgccttgccc atgctgaagc agagcaatgg cagcattgcc gtcatctcct      300

ccttggctgg gaaaatgacc tatcctatga ttgctcccta ctctgcaagc aagtttgctc      360

tggatgggtt cttttccacc attagaacag aactctacat aaccaaggtc aacgtgtcca      420

tcactctctg tgtccttggc ctcatagaca cagaaacagc tatgaaggaa atctctggga      480

tagttaacat gcaagcttct cccaaggagg agtgcgccct ggagatcatc aaaggcacag      540

ctctacgcaa aagcgaggtg tactatgaca aatcgccttt gactccaatc ctgcttggga      600

acccaggaag gaagatcatg gaattttttt cattacgata ttataataag gacatgtttg      660

taagtaacta g                                                           671


<210>  10
<211>  292
<212>  PRT
<213>  Mus musculus

<400>  10

Met Ala Val Met Lys Asn Tyr Leu Leu Pro Ile Leu Val Leu Phe Leu 
1               5                   10                  15      


Ala Tyr Tyr Tyr Tyr Ser Thr Asn Glu Glu Phe Arg Pro Glu Met Leu 
            20                  25                  30          


Gln Gly Lys Lys Val Ile Val Thr Gly Ala Ser Lys Gly Ile Gly Arg 
        35                  40                  45              


Glu Met Ala Tyr His Leu Ser Lys Met Gly Ala His Val Val Leu Thr 
    50                  55                  60                  


Ala Arg Ser Glu Glu Gly Leu Gln Lys Val Val Ser Arg Cys Leu Glu 
65                  70                  75                  80  


Leu Gly Ala Ala Ser Ala His Tyr Ile Ala Gly Thr Met Glu Asp Met 
                85                  90                  95      


Thr Phe Ala Glu Gln Phe Ile Val Lys Ala Gly Lys Leu Met Gly Gly 
            100                 105                 110         


Leu Asp Met Leu Ile Leu Asn His Ile Thr Gln Thr Ser Leu Ser Leu 
        115                 120                 125             


Phe His Asp Asp Ile His Ser Val Arg Arg Val Met Glu Val Asn Phe 
    130                 135                 140                 


Leu Ser Tyr Val Val Met Ser Thr Ala Ala Leu Pro Met Leu Lys Gln 
145                 150                 155                 160 


Ser Asn Gly Ser Ile Ala Val Ile Ser Ser Leu Ala Gly Lys Met Thr 
                165                 170                 175     


Gln Pro Met Ile Ala Pro Tyr Ser Ala Ser Lys Phe Ala Leu Asp Gly 
            180                 185                 190         


Phe Phe Ser Thr Ile Arg Thr Glu Leu Tyr Ile Thr Lys Val Asn Val 
        195                 200                 205             


Ser Ile Thr Leu Cys Val Leu Gly Leu Ile Asp Thr Glu Thr Ala Met 
    210                 215                 220                 


Lys Glu Ile Ser Gly Ile Ile Asn Met Gln Ala Ser Pro Lys Glu Glu 
225                 230                 235                 240 


Cys Ala Leu Glu Ile Ile Lys Gly Thr Ala Leu Arg Lys Ser Glu Val 
                245                 250                 255     


Tyr Tyr Asp Lys Ser Pro Leu Thr Pro Ile Leu Leu Gly Asn Pro Gly 
            260                 265                 270         


Arg Lys Ile Met Glu Phe Phe Ser Leu Arg Tyr Tyr Asn Lys Asp Met 
        275                 280                 285             


Phe Val Ser Asn 
    290         


<210>  11
<211>  879
<212>  DNA
<213>  Mus musculus

<400>  11
atggcagtta tgaaaaatta cctcctcccg atcctggtgc tcttcctggc ctactactac       60

tattctacaa atgaagagtt cagaccagaa atgctccagg gaaagaaagt gattgtcact      120

ggggccagca aagggattgg aagagaaatg gcatatcatc tgtcaaaaat gggagcccat      180

gtggtattga ctgccaggtc ggaggaaggt ctccagaagg tagtgtctcg ctgccttgaa      240

ctcggagcag cctctgctca ctacattgct ggcactatgg aagacatgac atttgcggag      300

caatttattg tcaaggcggg aaagctcatg ggcggactgg acatgcttat tctaaaccac      360

atcactcaga cctcgctgtc tctcttccat gacgacatcc actctgtgcg aagagtcatg      420

gaggtcaact tcctcagcta cgtggtcatg agcacagccg ccttgcccat gctgaagcag      480

agcaatggca gcattgccgt catctcctcc ttggctggga aaatgaccta tcctatgatt      540

gctccctact ctgcaagcaa gtttgctctg gatgggttct tttccaccat tagaacagaa      600

ctctacataa ccaaggtcaa cgtgtccatc actctctgtg tccttggcct catagacaca      660

gaaacagcta tgaaggaaat ctctgggata gttaacatgc aagcttctcc caaggaggag      720

tgcgccctgg agatcatcaa aggcacagct ctacgcaaaa gcgaggtgta ctatgacaaa      780

tcgcctttga ctccaatcct gcttgggaac ccaggaagga agatcatgga atttttttca      840

ttacgatatt ataataagga catgtttgta agtaactag                             879


<210>  12
<211>  292
<212>  PRT
<213>  Mus musculus

<400>  12

Met Ala Val Met Lys Asn Tyr Leu Leu Pro Ile Leu Val Leu Phe Leu 
1               5                   10                  15      


Ala Tyr Tyr Tyr Tyr Ser Thr Asn Glu Glu Phe Arg Pro Glu Met Leu 
            20                  25                  30          


Gln Gly Lys Lys Val Ile Val Thr Gly Ala Ser Lys Gly Ile Gly Arg 
        35                  40                  45              


Glu Met Ala Tyr His Leu Ser Lys Met Gly Ala His Val Val Leu Thr 
    50                  55                  60                  


Ala Arg Ser Glu Glu Gly Leu Gln Lys Val Val Ser Arg Cys Leu Glu 
65                  70                  75                  80  


Leu Gly Ala Ala Ser Ala His Tyr Ile Ala Gly Thr Met Glu Asp Met 
                85                  90                  95      


Thr Phe Ala Glu Gln Phe Ile Val Lys Ala Gly Lys Leu Met Gly Gly 
            100                 105                 110         


Leu Asp Met Leu Ile Leu Asn His Ile Thr Gln Thr Ser Leu Ser Leu 
        115                 120                 125             


Phe His Asp Asp Ile His Ser Val Arg Arg Val Met Glu Val Asn Phe 
    130                 135                 140                 


Leu Ser Tyr Val Val Met Ser Thr Ala Ala Leu Pro Met Leu Lys Gln 
145                 150                 155                 160 


Ser Asn Gly Ser Ile Ala Val Ile Ser Ser Leu Ala Gly Lys Met Thr 
                165                 170                 175     


Tyr Pro Met Ile Ala Pro Tyr Ser Ala Ser Lys Phe Ala Leu Asp Gly 
            180                 185                 190         


Phe Phe Ser Thr Ile Arg Thr Glu Leu Tyr Ile Thr Lys Val Asn Val 
        195                 200                 205             


Ser Ile Thr Leu Cys Val Leu Gly Leu Ile Asp Thr Glu Thr Ala Met 
    210                 215                 220                 


Lys Glu Ile Ser Gly Ile Val Asn Met Gln Ala Ser Pro Lys Glu Glu 
225                 230                 235                 240 


Cys Ala Leu Glu Ile Ile Lys Gly Thr Ala Leu Arg Lys Ser Glu Val 
                245                 250                 255     


Tyr Tyr Asp Lys Ser Pro Leu Thr Pro Ile Leu Leu Gly Asn Pro Gly 
            260                 265                 270         


Arg Lys Ile Met Glu Phe Phe Ser Leu Arg Tyr Tyr Asn Lys Asp Met 
        275                 280                 285             


Phe Val Ser Asn 
    290         


<210>  13
<211>  879
<212>  DNA
<213>  Mus musculus

<400>  13
atggcagtta tgaaaaatta cctcctcccg atcctggtgc tcttcctggc ctactactac       60

tattctacaa atgaagagtt cagaccagaa atgctccagg gaaagaaagt gattgtcact      120

ggggccagca aagggattgg aagagaaatg gcatatcatc tgtcaaaaat gggagcccat      180

gtggtattga ctgccaggtc ggaggaaggt ctccagaagg tagtgtctcg ctgccttgaa      240

ctcggagcag cctctgctca ctacattgct ggcactatgg aagacatgac atttgcggag      300

caatttattg tcaaggcggg aaagctcatg ggcggactgg acatgcttat tctaaaccac      360

atcactcaga cctcgctgtc tctcttccat gacgacatcc actctgtgcg aagagtcatg      420

gaggtcaact tcctcagcta cgtggtcatg agcacagccg ccttgcccat gctgaagcag      480

agcaatggca gcattgccgt catctcctcc ttggctggga aaatgaccta tcctatgatt      540

gctccctact ctgcaagcaa gtttgctctg gatgggttct tttccaccat tagaacagaa      600

ctctacataa ccaaggtcaa cgtgtccatc actctctgtg tccttggcct catagacaca      660

gaaacagcta tgaaggaaat ctctgggata gttaacatgc aagcttctcc caaggaggag      720

tgcgccctgg agatcatcaa aggcacagct ctacgcaaaa gcgaggtgta ctatgacaaa      780

tcgcctttga ctccaatcct gcttgggaac ccaggaagga agatcatgga atttttttca      840

ttacgatatt ataataagga catgtttgta agtaactag                             879


<210>  14
<211>  292
<212>  PRT
<213>  Mus musculus

<400>  14

Met Ala Val Met Lys Asn Tyr Leu Leu Pro Ile Leu Val Leu Phe Leu 
1               5                   10                  15      


Ala Tyr Tyr Tyr Tyr Ser Thr Asn Glu Glu Phe Arg Pro Glu Met Leu 
            20                  25                  30          


Gln Gly Lys Lys Val Ile Val Thr Gly Ala Ser Lys Gly Ile Gly Arg 
        35                  40                  45              


Glu Met Ala Tyr His Leu Ser Lys Met Gly Ala His Val Val Leu Thr 
    50                  55                  60                  


Ala Arg Ser Glu Glu Gly Leu Gln Lys Val Val Ser Arg Cys Leu Glu 
65                  70                  75                  80  


Leu Gly Ala Ala Ser Ala His Tyr Ile Ala Gly Thr Met Glu Asp Met 
                85                  90                  95      


Thr Phe Ala Glu Gln Phe Ile Val Lys Ala Gly Lys Leu Met Gly Gly 
            100                 105                 110         


Leu Asp Met Leu Ile Leu Asn His Ile Thr Gln Thr Ser Leu Ser Leu 
        115                 120                 125             


Phe His Asp Asp Ile His Ser Val Arg Arg Val Met Glu Val Asn Phe 
    130                 135                 140                 


Leu Ser Tyr Val Val Met Ser Thr Ala Ala Leu Pro Met Leu Lys Gln 
145                 150                 155                 160 


Ser Asn Gly Ser Ile Ala Val Ile Ser Ser Leu Ala Gly Lys Met Thr 
                165                 170                 175     


Tyr Pro Met Val Ala Pro Tyr Ser Ala Ser Lys Phe Ala Leu Asp Gly 
            180                 185                 190         


Phe Phe Ser Thr Ile Arg Thr Glu Leu Tyr Ile Thr Lys Val Asn Val 
        195                 200                 205             


Ser Ile Thr Leu Cys Val Leu Gly Leu Ile Asp Thr Glu Thr Ala Met 
    210                 215                 220                 


Lys Ala Val Ser Gly Ile Val Asn Met Gln Ala Ser Pro Lys Glu Glu 
225                 230                 235                 240 


Cys Ala Leu Glu Ile Ile Lys Gly Thr Ala Leu Arg Lys Ser Glu Val 
                245                 250                 255     


Tyr Tyr Asp Lys Ser Pro Leu Thr Pro Ile Leu Leu Gly Asn Pro Gly 
            260                 265                 270         


Arg Lys Ile Met Glu Phe Phe Ser Leu Arg Tyr Tyr Asn Lys Asp Met 
        275                 280                 285             


Phe Val Ser Asn 
    290         


<210>  15
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  15
caccatggca gttatgaaaa att                                               23


<210>  16
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  16
ctagttactt acaaacatgt cctt                                              24


<210>  17
<211>  34
<212>  DNA
<213>  Mus musculus

<400>  17
ggctgggaaa atgacctatc ctatgattgc tccc                                   34


<210>  18
<211>  47
<212>  DNA
<213>  Mus musculus

<400>  18
cagctatgaa ggaaatctct gggatagtta acatgcaagc ttctccc                     47


<210>  19
<211>  47
<212>  DNA
<213>  Mus musculus

<400>  19
cagctatgaa ggaaatctct gggatagtta acatgcaagc ttctccc                     47


<210>  20
<211>  48
<212>  DNA
<213>  Mus musculus

<400>  20
tcagtcgtca tcgtccttgt agtccatgtt acttacaaac atgtcctt                    48


