
                                SEQUENCE LISTING

<110> Brandt, Cameron S.
      Kennedy, Jacob J.
      Xu, Wenfeng
      Yi, Eugene C.
      Fox, Brian A.
      Gao, Zeren
      Sivakumar, Pallavur V.

<120> B7 FAMILY MEMBER zB7H6 AND RELATED COMPOSITIONS AND METHODS 
  

<130> 07-20PC

<160> 34

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1365
<212> DNA
<213> Homo sapiens

<400> 1
atgacgtgga gggctgccgc ctccacgtgc gcggcgctcc tgattctgct gtgggcgctg 60
acgaccgaag gtgatctgaa agtagagatg atggcagggg ggactcagat cacacccctg 120
aatgacaatg tcaccatatt ctgcaatatc ttttattccc aacccctcaa catcacgtct 180
atgggtatca cctggttttg gaagagtctg acgtttgaca aagaagtcaa agtctttgaa 240
ttttttggag atcaccaaga ggcattccga cctggagcca ttgtgtctcc atggaggctg 300
aagagtgggg acgcctcact gcggctgcct ggaatccagc tggaggaagc aggagagtac 360
cgatgtgagg tggtggtcac ccctctgaag gcacagggaa cagtccagct tgaagttgtg 420
gcttccccag ccagcagatt gttgctggat caagtgggca tgaaagagaa tgaagacaaa 480
tatatgtgtg agtcaagtgg gttctaccca gaggctatta atataacatg ggagaagcag 540
acccagaagt ttccccatcc catagagatt tctgaggatg tcatcactgg tcccaccatc 600
aagaatatgg atggcacatt taatgtcact agctgcttga agctgaactc ctctcaggaa 660
gaccctggga ctgtctacca gtgtgtggta cggcatgcgt ccttgcatac ccccttgagg 720
agcaacttta ccctgactgc tgctcggcac agtctttctg aaactgagaa gacagataat 780
ttttccattc attggtggcc tatttcattc attggtgttg gactggtttt attaattgtt 840
ttgattcctt ggaaaaagat atgtaacaaa tcatcttcag cctatactcc tctcaagtgc 900
attctgaaac actggaactc ctttgacact cagactctga agaaagagca cctcatattc 960
ttttgcactc gggcatggcc gtcttaccag ctgcaggatg gggaggcttg gcctcctgag 1020
ggaagtgtta atattaatac tattcaacaa ctagatgttt tctgcagaca ggagggcaaa 1080
tggtccgagg ttccttatgt gcaagccttc tttgccttgc gagacaaccc agatctttgt 1140
cagtgttgta gaattgaccc tgctctccta acagttacat caggcaagtc catagatgat 1200
aattccacaa agtctgagaa acaaacccct agggaacact cggatgcagt tccggatgcc 1260
ccaatccttc ctgtctcccc tatctgggaa cctcctccag ccacaacatc aacaactcca 1320
gttctatcct cccaaccccc aactttactg ttacccctac agtaa                 1365

<210> 2
<211> 454
<212> PRT
<213> Homo sapiens

<400> 2
Met Thr Trp Arg Ala Ala Ala Ser Thr Cys Ala Ala Leu Leu Ile Leu
 1               5                  10                  15      
Leu Trp Ala Leu Thr Thr Glu Gly Asp Leu Lys Val Glu Met Met Ala
            20                  25                  30          
Gly Gly Thr Gln Ile Thr Pro Leu Asn Asp Asn Val Thr Ile Phe Cys
        35                  40                  45              
Asn Ile Phe Tyr Ser Gln Pro Leu Asn Ile Thr Ser Met Gly Ile Thr
    50                  55                  60                  
Trp Phe Trp Lys Ser Leu Thr Phe Asp Lys Glu Val Lys Val Phe Glu
65                  70                  75                  80  
Phe Phe Gly Asp His Gln Glu Ala Phe Arg Pro Gly Ala Ile Val Ser
                85                  90                  95      
Pro Trp Arg Leu Lys Ser Gly Asp Ala Ser Leu Arg Leu Pro Gly Ile
            100                 105                 110         
Gln Leu Glu Glu Ala Gly Glu Tyr Arg Cys Glu Val Val Val Thr Pro
        115                 120                 125             
Leu Lys Ala Gln Gly Thr Val Gln Leu Glu Val Val Ala Ser Pro Ala
    130                 135                 140                 
Ser Arg Leu Leu Leu Asp Gln Val Gly Met Lys Glu Asn Glu Asp Lys
145                 150                 155                 160 
Tyr Met Cys Glu Ser Ser Gly Phe Tyr Pro Glu Ala Ile Asn Ile Thr
                165                 170                 175     
Trp Glu Lys Gln Thr Gln Lys Phe Pro His Pro Ile Glu Ile Ser Glu
            180                 185                 190         
Asp Val Ile Thr Gly Pro Thr Ile Lys Asn Met Asp Gly Thr Phe Asn
        195                 200                 205             
Val Thr Ser Cys Leu Lys Leu Asn Ser Ser Gln Glu Asp Pro Gly Thr
    210                 215                 220                 
Val Tyr Gln Cys Val Val Arg His Ala Ser Leu His Thr Pro Leu Arg
225                 230                 235                 240 
Ser Asn Phe Thr Leu Thr Ala Ala Arg His Ser Leu Ser Glu Thr Glu
                245                 250                 255     
Lys Thr Asp Asn Phe Ser Ile His Trp Trp Pro Ile Ser Phe Ile Gly
            260                 265                 270         
Val Gly Leu Val Leu Leu Ile Val Leu Ile Pro Trp Lys Lys Ile Cys
        275                 280                 285             
Asn Lys Ser Ser Ser Ala Tyr Thr Pro Leu Lys Cys Ile Leu Lys His
    290                 295                 300                 
Trp Asn Ser Phe Asp Thr Gln Thr Leu Lys Lys Glu His Leu Ile Phe
305                 310                 315                 320 
Phe Cys Thr Arg Ala Trp Pro Ser Tyr Gln Leu Gln Asp Gly Glu Ala
                325                 330                 335     
Trp Pro Pro Glu Gly Ser Val Asn Ile Asn Thr Ile Gln Gln Leu Asp
            340                 345                 350         
Val Phe Cys Arg Gln Glu Gly Lys Trp Ser Glu Val Pro Tyr Val Gln
        355                 360                 365             
Ala Phe Phe Ala Leu Arg Asp Asn Pro Asp Leu Cys Gln Cys Cys Arg
    370                 375                 380                 
Ile Asp Pro Ala Leu Leu Thr Val Thr Ser Gly Lys Ser Ile Asp Asp
385                 390                 395                 400 
Asn Ser Thr Lys Ser Glu Lys Gln Thr Pro Arg Glu His Ser Asp Ala
                405                 410                 415     
Val Pro Asp Ala Pro Ile Leu Pro Val Ser Pro Ile Trp Glu Pro Pro
            420                 425                 430         
Pro Ala Thr Thr Ser Thr Thr Pro Val Leu Ser Ser Gln Pro Pro Thr
        435                 440                 445             
Leu Leu Leu Pro Leu Gln
    450                 


<210> 3
<211> 2207
<212> DNA
<213> Homo sapiens

<400> 3
ccccttcctg tggggttcat tggggcatcc cctttctgct gcaggaacct ctcatcagac 60
cgcctgaggg aagcggcgcc cggagacccg ccccggcccg gtccacattc tccccaggaa 120
gccggactct atggggcggg accctggggg agcctgagcc gagcccggag ccagccccga 180
acccctgaac ctccagccag gggcgccccg ggagcagcca gcccgtgggc gagccgcccg 240
cccgccgagc agccatgagc gagacggtca tctgttccag ccgggccact gtgatgcttt 300
atgatgatgg caacaagcga tggctccctg ctggcacggg tccccaggcc ttcagccgcg 360
tccagatcta ccacaacccc acggccaatt cctttcgcgt cgtgggccgg aagatgcagc 420
ccgaccagca ggtggtcatc aactgtgcca tcgtccgggg tgtcaagtat aaccaggcca 480
cccccaactt ccatcagtgg cgcgacgctc gccaggtctg gggcctcaac ttcggcagca 540
aggaggatgc ggcccagttt gccgccggca tggccagtgc cctagaggcg ttggaaggag 600
gtgggccccc tccaccccca gcacttccca cctggtcggt cccgaacggc ccctccccgg 660
aggaggtgga gcagcagaaa aggcagcagc ccggcccgtc ggagcacata gagcgccggg 720
tctccaatgc aggaggccca cctgctcccc ccgctggggg tccaccccca ccaccaggac 780
ctccccctcc tccaggtccc cccccacccc caggtttgcc cccttcgggg gtcccagctg 840
cagcgcacgg agcaggggga ggaccacccc ctgcaccccc tctcccggca gcacagggcc 900
ctggtggtgg gggagctggg gccccaggcc tggccgcagc tattgctgga gccaaactca 960
ggaaagtcag caagcaggag gaggcctcag gggggcccac agcccccaaa gctgagagtg 1020
gtcgaagcgg aggtggggga ctcatggaag agatgaacgc catgctggcc cggagaagga 1080
aagccacgca agttggggag aaaaccccca aggatgaatc tgccaatcag gaggagccag 1140
aggccagagt cccggcccag agtgaatctg tgcggagacc ctgggagaag aacagcacaa 1200
ccttgccaag gatgaagtcg tcttcttcgg tgaccacttc cgagacccaa ccctgcacgc 1260
ccagctccag tgattactcg gacctacaga gggtgaaaca ggagcttctg gaagaggtga 1320
agaaggaatt gcagaaagtg aaagaggaaa tcattgaagc cttcgtccag gagctgagga 1380
agcggggttc tccctgacca cagggaccca gaagacccgc ttctcctttc cgcacacccg 1440
gcctgtcacc ctgctttccc tgcctctact tgacttggaa ttggctgaag acacaggaat 1500
gcatcgttcc cactccccat cccacttgga aaactccaag ggggtgtggc ttccctgctc 1560
acacccacac tggctgctga ttggctgggg aggcccccgc ccttttctcc ctttggtcct 1620
tcccctctgc catccccttg gggccggtcc ctctgctggg gatgcaccaa tgaaccccac 1680
aggaaggggg aaggaaggag ggaatttcac attcccttgt tctagattca ctttaacgct 1740
taatgccttc aaagttttgg tttttttaag aaaaaaaaat atatatatat ttgggttttg 1800
ggggaaaagg gaaatttttt tttctctttg gttttgataa aatgggatgt gggagttttt 1860
aaatgctata gccctgggct tgccccattt ggggcagcta tttaagggga ggggatgtct 1920
caccgggctg ggggtgagat atccccccac cccagggact ccccttccct ctggctcctt 1980
ccccttttct atgaggaaat aagatgctgt aactttttgg aacctcagtt ttttgatttt 2040
ttatttgggt aggttttggg gtccaggcca ttttttttac cccttggagg aaataagatg 2100
agggagaaag gagaagggga ggaaacttct cccctcccac cttcaccttt agcttcttga 2160
aaatgggccc ctgcagaata aatctgccag tttttataaa aaaaaaa               2207

<210> 4
<211> 380
<212> PRT
<213> Homo sapiens

<400> 4
Met Ser Glu Thr Val Ile Cys Ser Ser Arg Ala Thr Val Met Leu Tyr
 1               5                  10                  15      
Asp Asp Gly Asn Lys Arg Trp Leu Pro Ala Gly Thr Gly Pro Gln Ala
            20                  25                  30          
Phe Ser Arg Val Gln Ile Tyr His Asn Pro Thr Ala Asn Ser Phe Arg
        35                  40                  45              
Val Val Gly Arg Lys Met Gln Pro Asp Gln Gln Val Val Ile Asn Cys
    50                  55                  60                  
Ala Ile Val Arg Gly Val Lys Tyr Asn Gln Ala Thr Pro Asn Phe His
65                  70                  75                  80  
Gln Trp Arg Asp Ala Arg Gln Val Trp Gly Leu Asn Phe Gly Ser Lys
                85                  90                  95      
Glu Asp Ala Ala Gln Phe Ala Ala Gly Met Ala Ser Ala Leu Glu Ala
            100                 105                 110         
Leu Glu Gly Gly Gly Pro Pro Pro Pro Pro Ala Leu Pro Thr Trp Ser
        115                 120                 125             
Val Pro Asn Gly Pro Ser Pro Glu Glu Val Glu Gln Gln Lys Arg Gln
    130                 135                 140                 
Gln Pro Gly Pro Ser Glu His Ile Glu Arg Arg Val Ser Asn Ala Gly
145                 150                 155                 160 
Gly Pro Pro Ala Pro Pro Ala Gly Gly Pro Pro Pro Pro Pro Gly Pro
                165                 170                 175     
Pro Pro Pro Pro Gly Pro Pro Pro Pro Pro Gly Leu Pro Pro Ser Gly
            180                 185                 190         
Val Pro Ala Ala Ala His Gly Ala Gly Gly Gly Pro Pro Pro Ala Pro
        195                 200                 205             
Pro Leu Pro Ala Ala Gln Gly Pro Gly Gly Gly Gly Ala Gly Ala Pro
    210                 215                 220                 
Gly Leu Ala Ala Ala Ile Ala Gly Ala Lys Leu Arg Lys Val Ser Lys
225                 230                 235                 240 
Gln Glu Glu Ala Ser Gly Gly Pro Thr Ala Pro Lys Ala Glu Ser Gly
                245                 250                 255     
Arg Ser Gly Gly Gly Gly Leu Met Glu Glu Met Asn Ala Met Leu Ala
            260                 265                 270         
Arg Arg Arg Lys Ala Thr Gln Val Gly Glu Lys Thr Pro Lys Asp Glu
        275                 280                 285             
Ser Ala Asn Gln Glu Glu Pro Glu Ala Arg Val Pro Ala Gln Ser Glu
    290                 295                 300                 
Ser Val Arg Arg Pro Trp Glu Lys Asn Ser Thr Thr Leu Pro Arg Met
305                 310                 315                 320 
Lys Ser Ser Ser Ser Val Thr Thr Ser Glu Thr Gln Pro Cys Thr Pro
                325                 330                 335     
Ser Ser Ser Asp Tyr Ser Asp Leu Gln Arg Val Lys Gln Glu Leu Leu
            340                 345                 350         
Glu Glu Val Lys Lys Glu Leu Gln Lys Val Lys Glu Glu Ile Ile Glu
        355                 360                 365             
Ala Phe Val Gln Glu Leu Arg Lys Arg Gly Ser Pro
    370                 375                 380 


<210> 5
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide Linker

<400> 5
Gly Ser Gly Gly
 1              


<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> FLAG tag

<400> 6
Asp Tyr Lys Asp Asp Asp Asp Lys
 1               5              


<210> 7
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Six-His tag

<400> 7
His His His His His His
 1               5      


<210> 8
<211> 365
<212> PRT
<213> Artificial Sequence

<220> 
<223> NKp30/mFc2

<400> 8
Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser
 1               5                  10                  15      
Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly
            20                  25                  30          
Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu
        35                  40                  45              
Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys
    50                  55                  60                  
Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu
65                  70                  75                  80  
Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg
                85                  90                  95      
Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val
            100                 105                 110         
Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu
        115                 120                 125             
Lys Glu His Pro Glu Pro Arg Ser Pro Thr Ile Lys Pro Cys Pro Pro
    130                 135                 140                 
Cys Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile
145                 150                 155                 160 
Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile
                165                 170                 175     
Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln
            180                 185                 190         
Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln
        195                 200                 205             
Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu
    210                 215                 220                 
Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Ala Phe Ala Cys Ala
225                 230                 235                 240 
Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys
                245                 250                 255     
Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro
            260                 265                 270         
Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr
        275                 280                 285             
Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys
    290                 295                 300                 
Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly
305                 310                 315                 320 
Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val
                325                 330                 335     
Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn
            340                 345                 350         
His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys
        355                 360                 365 


<210> 9
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide Primer

<400> 9
tcaggaattc gcaagatgac gtggagggct gccgcc                           36

<210> 10
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide Primer

<400> 10
ctgactcgag ttactgtagg ggtaacagta a                                31

<210> 11
<211> 187
<212> PRT
<213> Artificial Sequence

<220> 
<223> NKp30/VASP

<400> 11
Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser
 1               5                  10                  15      
Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly
            20                  25                  30          
Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu
        35                  40                  45              
Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys
    50                  55                  60                  
Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu
65                  70                  75                  80  
Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg
                85                  90                  95      
Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val
            100                 105                 110         
Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu
        115                 120                 125             
Lys Glu His Pro Glu Pro Arg Ser Gly Ser Gly Gly Ser Gly Gly Ser
    130                 135                 140                 
Asp Leu Gln Arg Val Lys Gln Glu Leu Leu Glu Glu Val Lys Lys Glu
145                 150                 155                 160 
Leu Gln Lys Val Lys Glu Glu Ile Ile Glu Ala Phe Val Gln Glu Leu
                165                 170                 175     
Arg Gly Ser Gly Gly His His His His His His
            180                 185         


<210> 12
<211> 195
<212> PRT
<213> Artificial Sequence

<220> 
<223> zB7R1/VASP

<400> 12
Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala
 1               5                  10                  15      
Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn
            20                  25                  30          
Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser
        35                  40                  45              
Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln
    50                  55                  60                  
Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser
65                  70                  75                  80  
Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln
                85                  90                  95      
Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr
            100                 105                 110         
Tyr Pro Asp Gly Ala Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu
        115                 120                 125             
Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Glu Pro Arg Ser
    130                 135                 140                 
Gly Ser Gly Gly Ser Gly Gly Ser Asp Leu Gln Arg Val Lys Gln Glu
145                 150                 155                 160 
Leu Leu Glu Glu Val Lys Lys Glu Leu Gln Lys Val Lys Glu Glu Ile
                165                 170                 175     
Ile Glu Ala Phe Val Gln Glu Leu Arg Gly Ser Gly Gly His His His
            180                 185                 190         
His His His
        195 


<210> 13
<211> 276
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7DC/VASP

<400> 13
Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln
 1               5                  10                  15      
Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile
            20                  25                  30          
Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser
        35                  40                  45              
His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn
    50                  55                  60                  
Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu
65                  70                  75                  80  
Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp
                85                  90                  95      
Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr
            100                 105                 110         
Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr
        115                 120                 125             
His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln
    130                 135                 140                 
Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val
145                 150                 155                 160 
Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val
                165                 170                 175     
Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys
            180                 185                 190         
Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp
        195                 200                 205             
Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Glu Pro Arg
    210                 215                 220                 
Ser Gly Ser Gly Gly Ser Gly Gly Ser Asp Leu Gln Arg Val Lys Gln
225                 230                 235                 240 
Glu Leu Leu Glu Glu Val Lys Lys Glu Leu Gln Lys Val Lys Glu Glu
                245                 250                 255     
Ile Ile Glu Ala Phe Val Gln Glu Leu Arg Gly Ser Gly Gly His His
            260                 265                 270         
His His His His
        275     


<210> 14
<211> 687
<212> PRT
<213> Homo sapiens

<400> 14
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
 1               5                  10                  15      
Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg
            20                  25                  30          
Phe Arg Arg Thr Pro Lys Pro Glu Leu Trp Ala Glu Thr Asn Phe Pro
        35                  40                  45              
Leu Ala Pro Trp Lys Asn Leu Thr Leu Trp Cys Arg Ser Pro Ser Gly
    50                  55                  60                  
Ser Thr Lys Glu Phe Val Leu Leu Lys Asp Gly Thr Gly Trp Ile Ala
65                  70                  75                  80  
Thr Arg Pro Ala Ser Glu Gln Val Arg Ala Ala Phe Pro Leu Gly Ala
                85                  90                  95      
Leu Thr Gln Ser His Thr Gly Ser Tyr His Cys His Ser Trp Glu Glu
            100                 105                 110         
Met Ala Val Ser Glu Pro Ser Glu Ala Leu Glu Leu Val Gly Thr Asp
        115                 120                 125             
Ile Leu Pro Lys Pro Val Ile Ser Ala Ser Pro Thr Ile Arg Gly Gln
    130                 135                 140                 
Glu Leu Gln Leu Arg Cys Lys Gly Trp Leu Ala Gly Met Gly Phe Ala
145                 150                 155                 160 
Leu Tyr Lys Glu Gly Glu Gln Glu Pro Val Gln Gln Leu Gly Ala Val
                165                 170                 175     
Gly Arg Glu Ala Phe Phe Thr Ile Gln Arg Met Glu Asp Lys Asp Glu
            180                 185                 190         
Gly Asn Tyr Ser Cys Arg Thr His Thr Glu Lys Arg Pro Phe Lys Trp
        195                 200                 205             
Ser Glu Pro Ser Glu Pro Leu Glu Leu Val Ile Lys Glu Met Tyr Pro
    210                 215                 220                 
Lys Pro Phe Phe Lys Thr Trp Ala Ser Pro Val Val Thr Pro Gly Ala
225                 230                 235                 240 
Arg Val Thr Phe Asn Cys Ser Thr Pro His Gln His Met Ser Phe Ile
                245                 250                 255     
Leu Tyr Lys Asp Gly Ser Glu Ile Ala Ser Ser Asp Arg Ser Trp Ala
            260                 265                 270         
Ser Pro Gly Ala Ser Ala Ala His Phe Leu Ile Ile Ser Val Gly Ile
        275                 280                 285             
Gly Asp Gly Gly Asn Tyr Ser Cys Arg Tyr Tyr Asp Phe Ser Ile Trp
    290                 295                 300                 
Ser Glu Pro Ser Asp Pro Val Glu Leu Val Val Thr Glu Phe Tyr Pro
305                 310                 315                 320 
Lys Pro Thr Leu Leu Ala Gln Pro Gly Pro Val Val Phe Pro Gly Lys
                325                 330                 335     
Ser Val Ile Leu Arg Cys Gln Gly Thr Phe Gln Gly Met Arg Phe Ala
            340                 345                 350         
Leu Leu Gln Glu Gly Ala His Val Pro Leu Gln Phe Arg Ser Val Ser
        355                 360                 365             
Gly Asn Ser Ala Asp Phe Leu Leu His Thr Val Gly Ala Glu Asp Ser
    370                 375                 380                 
Gly Asn Tyr Ser Cys Ile Tyr Tyr Glu Thr Thr Met Ser Asn Arg Gly
385                 390                 395                 400 
Ser Tyr Leu Ser Met Pro Leu Met Ile Trp Val Thr Gly Leu Leu Pro
                405                 410                 415     
Lys Pro Ser Leu Leu Ala Gln Pro Gly Pro Met Val Ala Pro Gly Glu
            420                 425                 430         
Asn Met Thr Leu Gln Cys Gln Gly Glu Leu Pro Asp Ser Thr Phe Val
        435                 440                 445             
Leu Leu Lys Glu Gly Ala Gln Glu Pro Leu Glu Gln Gln Arg Pro Ser
    450                 455                 460                 
Gly Tyr Arg Ala Asp Phe Trp Met Pro Ala Val Arg Gly Glu Asp Ser
465                 470                 475                 480 
Gly Ile Tyr Ser Cys Val Tyr Tyr Leu Asp Ser Thr Pro Phe Ala Ala
                485                 490                 495     
Ser Asn His Ser Asp Ser Leu Glu Ile Trp Val Thr Asp Lys Pro Pro
            500                 505                 510         
Lys Pro Ser Leu Ser Ala Trp Pro Ser Thr Met Phe Lys Leu Gly Lys
        515                 520                 525             
Asp Ile Thr Leu Gln Cys Arg Gly Pro Leu Pro Gly Val Glu Phe Val
    530                 535                 540                 
Leu Glu His Asp Gly Glu Glu Ala Pro Gln Gln Phe Ser Glu Asp Gly
545                 550                 555                 560 
Asp Phe Val Ile Asn Asn Val Glu Gly Lys Gly Ile Gly Asn Tyr Ser
                565                 570                 575     
Cys Ser Tyr Arg Leu Gln Ala Tyr Pro Asp Ile Trp Ser Glu Pro Ser
            580                 585                 590         
Asp Pro Leu Glu Leu Val Gly Ala Ala Gly Pro Val Ala Gln Glu Cys
        595                 600                 605             
Thr Val Gly Asn Ile Val Arg Ser Ser Leu Ile Val Val Val Val Val
    610                 615                 620                 
Ala Leu Gly Val Val Leu Ala Ile Glu Trp Lys Lys Trp Pro Arg Leu
625                 630                 635                 640 
Arg Thr Arg Gly Ser Glu Thr Asp Gly Arg Asp Gln Thr Ile Ala Leu
                645                 650                 655     
Glu Glu Cys Asn Gln Glu Gly Glu Pro Gly Thr Pro Ala Asn Ser Pro
            660                 665                 670         
Ser Ser Thr Ser Gln Arg Ile Ser Val Glu Leu Pro Val Pro Ile
        675                 680                 685         


<210> 15
<211> 290
<212> PRT
<213> Homo sapiens

<400> 15
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu
 1               5                  10                  15      
Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr
            20                  25                  30          
Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu
        35                  40                  45              
Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile
    50                  55                  60                  
Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser
65                  70                  75                  80  
Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn
                85                  90                  95      
Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr
            100                 105                 110         
Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val
        115                 120                 125             
Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val
    130                 135                 140                 
Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr
145                 150                 155                 160 
Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser
                165                 170                 175     
Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn
            180                 185                 190         
Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr
        195                 200                 205             
Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu
    210                 215                 220                 
Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His
225                 230                 235                 240 
Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr
                245                 250                 255     
Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys
            260                 265                 270         
Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu
        275                 280                 285             
Glu Thr
    290 


<210> 16
<211> 1500
<212> DNA
<213> Artificial Sequence

<220> 
<223> zB7H6/mFc2

<400> 16
atgacgtgga gggctgccgc ctccacgtgc gcggcgctcc tgattctgct gtgggcgctg 60
acgaccgaag gtgatctgaa agtagagatg atggcagggg ggactcagat cacacccctg 120
aatgacaatg tcaccatatt ctgcaatatc ttttattccc aacccctcaa catcacgtct 180
atgggtatca cctggttttg gaagagtctg acgtttgaca aagaagtcaa agtctttgaa 240
ttttttggag atcaccaaga ggcattccga cctggagcca ttgtgtctcc atggaggctg 300
aagagtgggg acgcctcact gcggctgcct ggaatccagc tggaggaagc aggagagtac 360
cgatgtgagg tggtggtcac ccctctgaag gcacagggaa cagtccagct tgaagttgtg 420
gcttccccag ccagcagatt gttgctggat caagtgggca tgaaagagaa tgaagacaaa 480
tatatgtgtg agtcaagtgg gttctaccca gaggctatta atataacatg ggagaagcag 540
acccagaagt ttccccatcc catagagatt tctgaggatg tcatcactgg tcccaccatc 600
aagaatatgg atggcacatt taatgtcact agctgcttga agctgaactc ctctcaggaa 660
gaccctggga ctgtctacca gtgtgtggta cggcatgcgt ccttgcatac ccccttgagg 720
agcaacttta ccctgactgc tgctcggcac agtctttctg aaactgagaa gacagataat 780
ttttccattc attggtggcc tgagcccaga tctcccacaa tcaagccctg tcctccatgc 840
aaatgcccag cacctaacct cgagggtgga ccatccgtct tcatcttccc tccaaagatc 900
aaggatgtac tcatgatctc cctgagcccc atagtcacat gtgtggtggt ggatgtgagc 960
gaggatgacc cagatgtcca gatcagctgg tttgtgaaca acgtggaagt acacacagct 1020
cagacacaaa cccatagaga ggattacaac agtactctcc gggtggtcag tgccctcccc 1080
atccagcacc aggactggat gagtggcaaa gctttcgcat gcgcggtcaa caacaaagac 1140
ctcccagcgc ccatcgagag aaccatctca aaacccaaag ggtcagtaag agctccacag 1200
gtatatgtct tgcctccacc agaagaagag atgactaaga aacaggtcac tctgacctgc 1260
atggtcacag acttcatgcc tgaagacatt tacgtggagt ggaccaacaa cgggaaaaca 1320
gagctaaact acaagaacac tgaaccagtc ctggactctg atggttctta cttcatgtac 1380
agcaagctga gagtggaaaa gaagaactgg gtggaaagaa atagctactc ctgttcagtg 1440
gtccacgagg gtctgcacaa tcaccacacg actaagagct tctcccggac tccgggtaaa 1500


<210> 17
<211> 500
<212> PRT
<213> Artificial Sequence

<220> 
<223> zB7H6/mFc2

<400> 17
Met Thr Trp Arg Ala Ala Ala Ser Thr Cys Ala Ala Leu Leu Ile Leu
 1               5                  10                  15      
Leu Trp Ala Leu Thr Thr Glu Gly Asp Leu Lys Val Glu Met Met Ala
            20                  25                  30          
Gly Gly Thr Gln Ile Thr Pro Leu Asn Asp Asn Val Thr Ile Phe Cys
        35                  40                  45              
Asn Ile Phe Tyr Ser Gln Pro Leu Asn Ile Thr Ser Met Gly Ile Thr
    50                  55                  60                  
Trp Phe Trp Lys Ser Leu Thr Phe Asp Lys Glu Val Lys Val Phe Glu
65                  70                  75                  80  
Phe Phe Gly Asp His Gln Glu Ala Phe Arg Pro Gly Ala Ile Val Ser
                85                  90                  95      
Pro Trp Arg Leu Lys Ser Gly Asp Ala Ser Leu Arg Leu Pro Gly Ile
            100                 105                 110         
Gln Leu Glu Glu Ala Gly Glu Tyr Arg Cys Glu Val Val Val Thr Pro
        115                 120                 125             
Leu Lys Ala Gln Gly Thr Val Gln Leu Glu Val Val Ala Ser Pro Ala
    130                 135                 140                 
Ser Arg Leu Leu Leu Asp Gln Val Gly Met Lys Glu Asn Glu Asp Lys
145                 150                 155                 160 
Tyr Met Cys Glu Ser Ser Gly Phe Tyr Pro Glu Ala Ile Asn Ile Thr
                165                 170                 175     
Trp Glu Lys Gln Thr Gln Lys Phe Pro His Pro Ile Glu Ile Ser Glu
            180                 185                 190         
Asp Val Ile Thr Gly Pro Thr Ile Lys Asn Met Asp Gly Thr Phe Asn
        195                 200                 205             
Val Thr Ser Cys Leu Lys Leu Asn Ser Ser Gln Glu Asp Pro Gly Thr
    210                 215                 220                 
Val Tyr Gln Cys Val Val Arg His Ala Ser Leu His Thr Pro Leu Arg
225                 230                 235                 240 
Ser Asn Phe Thr Leu Thr Ala Ala Arg His Ser Leu Ser Glu Thr Glu
                245                 250                 255     
Lys Thr Asp Asn Phe Ser Ile His Trp Trp Pro Glu Pro Arg Ser Pro
            260                 265                 270         
Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Glu
        275                 280                 285             
Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu
    290                 295                 300                 
Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser
305                 310                 315                 320 
Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu
                325                 330                 335     
Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr
            340                 345                 350         
Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser
        355                 360                 365             
Gly Lys Ala Phe Ala Cys Ala Val Asn Asn Lys Asp Leu Pro Ala Pro
    370                 375                 380                 
Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln
385                 390                 395                 400 
Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val
                405                 410                 415     
Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val
            420                 425                 430         
Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu
        435                 440                 445             
Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg
    450                 455                 460                 
Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val
465                 470                 475                 480 
Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg
                485                 490                 495     
Thr Pro Gly Lys
            500 


<210> 18
<211> 969
<212> DNA
<213> Artificial Sequence

<220> 
<223> zB7H6/VASP

<400> 18
atgacgtgga gggctgccgc ctccacgtgc gcggcgctcc tgattctgct gtgggcgctg 60
acgaccgaag gtgatctgaa agtagagatg atggcagggg ggactcagat cacacccctg 120
aatgacaatg tcaccatatt ctgcaatatc ttttattccc aacccctcaa catcacgtct 180
atgggtatca cctggttttg gaagagtctg acgtttgaca aagaagtcaa agtctttgaa 240
ttttttggag atcaccaaga ggcattccga cctggagcca ttgtgtctcc atggaggctg 300
aagagtgggg acgcctcact gcggctgcct ggaatccagc tggaggaagc aggagagtac 360
cgatgtgagg tggtggtcac ccctctgaag gcacagggaa cagtccagct tgaagttgtg 420
gcttccccag ccagcagatt gttgctggat caagtgggca tgaaagagaa tgaagacaaa 480
tatatgtgtg agtcaagtgg gttctaccca gaggctatta atataacatg ggagaagcag 540
acccagaagt ttccccatcc catagagatt tctgaggatg tcatcactgg tcccaccatc 600
aagaatatgg atggcacatt taatgtcact agctgcttga agctgaactc ctctcaggaa 660
gaccctggga ctgtctacca gtgtgtggta cggcatgcgt ccttgcatac ccccttgagg 720
agcaacttta ccctgactgc tgctcggcac agtctttctg aaactgagaa gacagataat 780
ttttccattc attggtggcc tgagcccaga tctggttccg gaggctccgg tggctccgac 840
ctacagaggg tgaaacagga gcttctggaa gaggtgaaga aggaattgca gaaagtgaaa 900
gaggaaatca ttgaagcctt cgtccaggag ctgaggggtt ccggtggcca tcaccatcac 960
catcactga                                                         969

<210> 19
<211> 322
<212> PRT
<213> Artificial Sequence

<220> 
<223> zB7H6/VASP

<400> 19
Met Thr Trp Arg Ala Ala Ala Ser Thr Cys Ala Ala Leu Leu Ile Leu
 1               5                  10                  15      
Leu Trp Ala Leu Thr Thr Glu Gly Asp Leu Lys Val Glu Met Met Ala
            20                  25                  30          
Gly Gly Thr Gln Ile Thr Pro Leu Asn Asp Asn Val Thr Ile Phe Cys
        35                  40                  45              
Asn Ile Phe Tyr Ser Gln Pro Leu Asn Ile Thr Ser Met Gly Ile Thr
    50                  55                  60                  
Trp Phe Trp Lys Ser Leu Thr Phe Asp Lys Glu Val Lys Val Phe Glu
65                  70                  75                  80  
Phe Phe Gly Asp His Gln Glu Ala Phe Arg Pro Gly Ala Ile Val Ser
                85                  90                  95      
Pro Trp Arg Leu Lys Ser Gly Asp Ala Ser Leu Arg Leu Pro Gly Ile
            100                 105                 110         
Gln Leu Glu Glu Ala Gly Glu Tyr Arg Cys Glu Val Val Val Thr Pro
        115                 120                 125             
Leu Lys Ala Gln Gly Thr Val Gln Leu Glu Val Val Ala Ser Pro Ala
    130                 135                 140                 
Ser Arg Leu Leu Leu Asp Gln Val Gly Met Lys Glu Asn Glu Asp Lys
145                 150                 155                 160 
Tyr Met Cys Glu Ser Ser Gly Phe Tyr Pro Glu Ala Ile Asn Ile Thr
                165                 170                 175     
Trp Glu Lys Gln Thr Gln Lys Phe Pro His Pro Ile Glu Ile Ser Glu
            180                 185                 190         
Asp Val Ile Thr Gly Pro Thr Ile Lys Asn Met Asp Gly Thr Phe Asn
        195                 200                 205             
Val Thr Ser Cys Leu Lys Leu Asn Ser Ser Gln Glu Asp Pro Gly Thr
    210                 215                 220                 
Val Tyr Gln Cys Val Val Arg His Ala Ser Leu His Thr Pro Leu Arg
225                 230                 235                 240 
Ser Asn Phe Thr Leu Thr Ala Ala Arg His Ser Leu Ser Glu Thr Glu
                245                 250                 255     
Lys Thr Asp Asn Phe Ser Ile His Trp Trp Pro Glu Pro Arg Ser Gly
            260                 265                 270         
Ser Gly Gly Ser Gly Gly Ser Asp Leu Gln Arg Val Lys Gln Glu Leu
        275                 280                 285             
Leu Glu Glu Val Lys Lys Glu Leu Gln Lys Val Lys Glu Glu Ile Ile
    290                 295                 300                 
Glu Ala Phe Val Gln Glu Leu Arg Gly Ser Gly Gly His His His His
305                 310                 315                 320 
His His
        


<210> 20
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 20
tccacaggtg tccagggaat tcaccatgca tggctggctg ctc                   43

<210> 21
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 21
agggcttgat tgtgggagat ctgggctcgg cagtctggaa ctgagc                46

<210> 22
<211> 104
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 22
acgcttccgt agatctggtt ccggaggctc cggtggctcc gacctacaga gggtgaaaca 60
ggagcttctg gaagaggtga agaaggaatt gcagaaagtg aaag                  104

<210> 23
<211> 104
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 23
aaggcgcgcc tctagatcag tgatggtgat ggtgatggcc accggaaccc ctcagctcct 60
ggacgaaggc ttcaatgatt tcctctttca ctttctgcaa ttcc                  104

<210> 24
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 24
ctcagccagg aaatccatgc cgagttgaga cgcttccgta gatctgg               47

<210> 25
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 25
ggggtgggta caaccccaga gctgttttaa ggcgcgcctc tagatc                46

<210> 26
<211> 70
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 26
ttgacatcca ctttgccttt ctctccacag gtgtccaggg aattcgcaaa tgacgtggag 60
ggctgccgcc                                                        70

<210> 27
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide primer

<400> 27
caccctctgt aggtcggagc caccggagcc tccggaacca gatctgggct caggccacca 60
atgaatggaa aa                                                     72

<210> 28
<211> 514
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7H3/VASP

<400> 28
Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala
 1               5                  10                  15      
Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln
            20                  25                  30          
Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu
        35                  40                  45              
Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn
    50                  55                  60                  
Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala
65                  70                  75                  80  
Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe
                85                  90                  95      
Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val
            100                 105                 110         
Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp
        115                 120                 125             
Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys
    130                 135                 140                 
Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr
145                 150                 155                 160 
Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val
                165                 170                 175     
Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr
            180                 185                 190         
Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu
        195                 200                 205             
Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn
    210                 215                 220                 
Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln
225                 230                 235                 240 
Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val
                245                 250                 255     
Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro
            260                 265                 270         
Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr
        275                 280                 285             
Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly
    290                 295                 300                 
Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln
305                 310                 315                 320 
Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly
                325                 330                 335     
Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val
            340                 345                 350         
Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu
        355                 360                 365             
Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser
    370                 375                 380                 
Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln
385                 390                 395                 400 
Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu
                405                 410                 415     
Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala
            420                 425                 430         
Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp
        435                 440                 445             
Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Ser Gly
    450                 455                 460                 
Ser Gly Gly Ser Gly Gly Ser Asp Leu Gln Arg Val Lys Gln Glu Leu
465                 470                 475                 480 
Leu Glu Glu Val Lys Lys Glu Leu Gln Lys Val Lys Glu Glu Ile Ile
                485                 490                 495     
Glu Ala Phe Val Gln Glu Leu Arg Gly Ser Gly Gly His His His His
            500                 505                 510         
His His
        


<210> 29
<211> 232
<212> PRT
<213> Homo sapien

<400> 29
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
            100                 105                 110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys
225                 230         


<210> 30
<211> 232
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc-488

<400> 30
Glu Pro Arg Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
            100                 105                 110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys
225                 230         


<210> 31
<211> 232
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc-4

<400> 31
Glu Pro Arg Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
            100                 105                 110         
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys
225                 230         


<210> 32
<211> 232
<212> PRT
<213> Artificial Sequence

<220> 
<223> Effector function minus Fc (Fc5)

<400> 32
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
            100                 105                 110         
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys
225                 230         


<210> 33
<211> 231
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc6

<400> 33
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
            100                 105                 110         
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly
225                 230     


<210> 34
<211> 232
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc7

<400> 34
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65                  70                  75                  80  
Tyr Glu Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
            100                 105                 110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys
225                 230         


