                         SEQUENCE LISTING

<110>  Navigen Pharmaceuticals
       Zhang, Kang
 
<120>  Antibodies to HTRA1 and methods of using the same

<130>  38263/8

<160>  4     

<170>  PatentIn version 3.4

<210>  1
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  1

Leu His Arg Pro Pro Val Ile Val Leu Gln Arg Gly Ala Cys Gly Gln 
1               5                   10                  15      


Gly Gln Glu Asp Pro Asn Ser Leu Arg His Lys Tyr Asn Phe Ile Ala 
            20                  25                  30          


Asp Val Val Glu Lys Ile Ala Pro Ala Val Val His Ile Glu Leu Phe 
        35                  40                  45              


Arg Lys Leu Pro Phe Ser Lys Arg Glu Val Pro Val Ala Ser Gly Ser 
    50                  55                  60                  


Gly Phe Ile Val Ser Glu Asp Gly Leu Ile Val Thr Asn Ala His Val 
65                  70                  75                  80  


Val Thr Asn Lys His Arg Val Lys Val Glu Leu Lys Asn Gly Ala Thr 
                85                  90                  95      


Tyr Glu Ala Lys Ile Lys Asp Val Asp Glu Lys Ala Asp Ile Ala Leu 
            100                 105                 110         


Ile Lys Ile Asp His Gln Gly Lys Leu Pro Val Leu Leu Leu Gly Arg 
        115                 120                 125             


Ser Ser Glu Leu Arg Pro Gly Glu Phe Val Val Ala Ile Gly Ser Pro 
    130                 135                 140                 


Phe Ser Leu Gln Asn Thr Val Thr Thr Gly Ile Val Ser Thr Thr Gln 
145                 150                 155                 160 


Arg Gly Gly Lys Glu Leu Gly Leu Arg Asn Ser Asp Met Asp Tyr Ile 
                165                 170                 175     


Gln Thr Asp Ala Ile Ile Asn Tyr Gly Asn Ser Gly Gly Pro Leu Val 
            180                 185                 190         


Asn Leu Asp Gly Glu Val Ile Gly Ile Asn Thr Leu Lys Val Thr Ala 
        195                 200                 205             


Gly Ile Ser Phe Ala Ile Pro Ser Asp Lys Ile Lys Lys Phe Leu Thr 
    210                 215                 220                 


Glu Ser His Asp Arg Gln Ala Lys Gly Lys Ala Ile Thr Lys Lys Lys 
225                 230                 235                 240 


Tyr Ile Gly Ile Arg Met Met Ser Leu Thr Ser Ser Lys Ala Lys Glu 
                245                 250                 255     


Leu Lys Asp Arg His Arg Asp Phe Pro Asp Val Ile Ser Gly Ala Tyr 
            260                 265                 270         


Ile Ile Glu Val Ile Pro Asp Thr Pro Ala Glu Ala Gly Gly Leu Lys 
        275                 280                 285             


Glu Asn Asp Val Ile Ile Ser Ile Asn Gly Gln Ser Val Val Ser Ala 
    290                 295                 300                 


Asn Asp Val Ser Asp Val Ile Lys Arg Glu Ser Thr Leu Asn Met Val 
305                 310                 315                 320 


Val Arg Arg Gly Asn Glu Asp Ile Met Ile Thr Val Ile Pro Glu Glu 
                325                 330                 335     


Ile Asp Pro 
            


<210>  2
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Ile Pro Arg Ala Ala Leu Leu Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Pro Ala Ser Ala Gln Leu Ser Arg Ala Gly Arg Ser Ala Pro 
            20                  25                  30          


Leu Ala Ala Gly Cys Pro Asp Arg Cys Glu Pro Ala Arg Cys Pro Pro 
        35                  40                  45              


Gln Pro Glu His Cys Glu Gly Gly Arg Ala Arg Asp Ala Cys Gly Cys 
    50                  55                  60                  


Cys Glu Val Cys Gly Ala Pro Glu Gly Ala Ala Cys Gly Leu Gln Glu 
65                  70                  75                  80  


Gly Pro Cys Gly Glu Gly Leu Gln Cys Val Val Pro Phe Gly Val Pro 
                85                  90                  95      


Ala Ser Ala Thr Val Arg Arg Arg Ala Gln Ala Gly Leu Cys Val Cys 
            100                 105                 110         


Ala Ser Ser Glu Pro Val Cys Gly Ser Asp Ala Asn Thr Tyr Ala Asn 
        115                 120                 125             


Leu Cys Gln Leu Arg Ala Ala Ser Arg Arg Ser Glu Arg Leu His Arg 
    130                 135                 140                 


Pro Pro Val Ile Val Leu Gln Arg Gly Ala Cys Gly Gln Gly Gln Glu 
145                 150                 155                 160 


Asp Pro Asn Ser Leu Arg His Lys Tyr Asn Phe Ile Ala Asp Val Val 
                165                 170                 175     


Glu Lys Ile Ala Pro Ala Val Val His Ile Glu Leu Phe Arg Lys Leu 
            180                 185                 190         


Pro Phe Ser Lys Arg Glu Val Pro Val Ala Ser Gly Ser Gly Phe Ile 
        195                 200                 205             


Val Ser Glu Asp Gly Leu Ile Val Thr Asn Ala His Val Val Thr Asn 
    210                 215                 220                 


Lys His Arg Val Lys Val Glu Leu Lys Asn Gly Ala Thr Tyr Glu Ala 
225                 230                 235                 240 


Lys Ile Lys Asp Val Asp Glu Lys Ala Asp Ile Ala Leu Ile Lys Ile 
                245                 250                 255     


Asp His Gln Gly Lys Leu Pro Val Leu Leu Leu Gly Arg Ser Ser Glu 
            260                 265                 270         


Leu Arg Pro Gly Glu Phe Val Val Ala Ile Gly Ser Pro Phe Ser Leu 
        275                 280                 285             


Gln Asn Thr Val Thr Thr Gly Ile Val Ser Thr Thr Gln Arg Gly Gly 
    290                 295                 300                 


Lys Glu Leu Gly Leu Arg Asn Ser Asp Met Asp Tyr Ile Gln Thr Asp 
305                 310                 315                 320 


Ala Ile Ile Asn Tyr Gly Asn Ser Gly Gly Pro Leu Val Asn Leu Asp 
                325                 330                 335     


Gly Glu Val Ile Gly Ile Asn Thr Leu Lys Val Thr Ala Gly Ile Ser 
            340                 345                 350         


Phe Ala Ile Pro Ser Asp Lys Ile Lys Lys Phe Leu Thr Glu Ser His 
        355                 360                 365             


Asp Arg Gln Ala Lys Gly Lys Ala Ile Thr Lys Lys Lys Tyr Ile Gly 
    370                 375                 380                 


Ile Arg Met Met Ser Leu Thr Ser Ser Lys Ala Lys Glu Leu Lys Asp 
385                 390                 395                 400 


Arg His Arg Asp Phe Pro Asp Val Ile Ser Gly Ala Tyr Ile Ile Glu 
                405                 410                 415     


Val Ile Pro Asp Thr Pro Ala Glu Ala Gly Gly Leu Lys Glu Asn Asp 
            420                 425                 430         


Val Ile Ile Ser Ile Asn Gly Gln Ser Val Val Ser Ala Asn Asp Val 
        435                 440                 445             


Ser Asp Val Ile Lys Arg Glu Ser Thr Leu Asn Met Val Val Arg Arg 
    450                 455                 460                 


Gly Asn Glu Asp Ile Met Ile Thr Val Ile Pro Glu Glu Ile Asp Pro 
465                 470                 475                 480 


<210>  3
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  3
acgcgtcgac aaaggctgca ccggccgccg gt                                   32


<210>  4
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  4
ataagaatgc ggccgcctat gggtcaattt cttcgg                               36


