                         SEQUENCE LISTING

<110>  Biogen Idec MA Inc., et al.
      
<120>  CD23 BINDING MOLECULES AND METHODS OF USE THEREOF

<130>  BGN-A250PC

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 60/995747
<151>  2007-09-27

<160>  107   

<170>  PatentIn version 3.5

<210>  1
<211>  2115
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  1
gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc ctggggggtc cctgagactc       60

tcctgcgcag cctccgggtt caggttcacc ttcaataact actacatgga ctgggtccgc      120

caggctccag ggcaggggct ggagtgggtc tcacgtatta gtagtagtgg tgatcccaca      180

tggtacgcag actccgtgaa gggcagattc accatctcca gagagaacgc caagaacaca      240

ctgtttcttc aaatgaacag cctgagagct gaggacacgg ctgtctatta ctgtgcgagc      300

ttgactacag ggtctgactc ctggggccag ggagtcctgg tcaccgtctc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaatccggc gggggtggat ccggtggagg gggctccggc     1380

ggtggcgggt ccgacatcca gatgacccag tctccatctt ccctgtctgc atctgtaggg     1440

gacagagtca ccatcacttg cagggcaagt caggacatta ggtattattt aaattggtat     1500

cagcagaaac caggaaaagc tcctaagctc ctgatctatg ttgcatccag tttgcaaagt     1560

ggggtcccat caaggttcag cggcagtgga tctgggacag agttcactct caccgtcagc     1620

agcctgcagc ctgaagattt tgcgacttat tactgtctac aggtttatag tacccctcgg     1680

acgttcggcc aagggaccaa ggtggaaatc aaaggcggtg gcgggtccgg tgggggtggc     1740

tccgggggcg gtggctccga ggtgcagctg gtggagtctg ggggcggctt ggcaaagcct     1800

ggggggtccc tgagactctc ctgcgcagcc tccgggttca ggttcacctt caataactac     1860

tacatggact gggtccgcca ggctccaggg caggggctgg agtgggtctc acgtattagt     1920

agtagtggtg atcccacatg gtacgcagac tccgtgaagg gcagattcac catctccaga     1980

gagaacgcca agaacacact gtttcttcaa atgaacagcc tgagagctga ggacacggct     2040

gtctattact gtgcgagctt gactacaggg tctgactcct ggggccaggg agtcctggtc     2100

accgtctcct catga                                                      2115


<210>  2
<211>  704
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Thr Phe Asn 
            20                  25                  30          


Asn Tyr Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Arg Ile Ser Ser Ser Gly Asp Pro Thr Trp Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Leu Thr Thr Gly Ser Asp Ser Trp Gly Gln Gly Val 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
465                 470                 475                 480 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Tyr Tyr 
                485                 490                 495     


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            500                 505                 510         


Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
        515                 520                 525             


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
    530                 535                 540                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Val Tyr Ser Thr Pro Arg 
545                 550                 555                 560 


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
                565                 570                 575     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
            580                 585                 590         


Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        595                 600                 605             


Ala Ala Ser Gly Phe Arg Phe Thr Phe Asn Asn Tyr Tyr Met Asp Trp 
    610                 615                 620                 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Ser Arg Ile Ser 
625                 630                 635                 640 


Ser Ser Gly Asp Pro Thr Trp Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                645                 650                 655     


Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Asn 
            660                 665                 670         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Leu Thr 
        675                 680                 685             


Thr Gly Ser Asp Ser Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser 
    690                 695                 700                 


<210>  3
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  3
gacatccaga tgacccagtc tccatcttcc ctgtctgcat ctgtagggga cagagtcacc       60

atcacttgca gggcaagtca ggacattagg tattatttaa attggtatca gcagaaacca      120

ggaaaagctc ctaagctcct gatctatgtt gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagag ttcactctca ccgtcagcag cctgcagcct      240

gaagattttg cgacttatta ctgtctacag gtttatagta cccctcggac gttcggccaa      300

gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttga                      645


<210>  4
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Tyr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Val Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  5
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  5
gacatccaga tgacccagtc tccatcttcc ctgtctgcat ctgtagggga cagagtcacc       60

atcacttgca gggcaagtca ggacattagg tattatttaa attggtatca gcagaaacca      120

ggaaaagctc ctaagctcct gatctatgtt gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagag ttcactctca ccgtcagcag cctgcagcct      240

gaagattttg cgacttatta ctgtctacag gtttatagta cccctcggac gttcggccaa      300

gggaccaagg tggaaatcaa aggcggtggc gggtccggtg ggggtggctc cgggggcggt      360

ggctccgagg tgcagctggt ggagtctggg ggcggcttgg caaagcctgg ggggtccctg      420

agactctcct gcgcagcctc cgggttcagg ttcaccttca ataactacta catggactgg      480

gtccgccagg ctccagggca ggggctggag tgggtctcac gtattagtag tagtggtgat      540

cccacatggt acgcagactc cgtgaagggc agattcacca tctccagaga gaacgccaag      600

aacacactgt ttcttcaaat gaacagcctg agagctgagg acacggctgt ctattactgt      660

gcgagcttga ctacagggtc tgactcctgg ggccagggag tcctggtcac cgtctcctca      720


<210>  6
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Tyr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Val Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Arg Phe Thr Phe Asn Asn Tyr Tyr Met Asp Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Ser Arg Ile Ser 
                165                 170                 175     


Ser Ser Gly Asp Pro Thr Trp Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Leu Thr 
    210                 215                 220                 


Thr Gly Ser Asp Ser Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


<210>  7
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  7
gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc ctggggggtc cctgagactc       60

tcctgcgcag cctccgggtt caggttcacc ttcaataact actacatgga ctgggtccgc      120

caggctccag ggcaggggct ggagtgggtc tcacgtatta gtagtagtgg tgatcccaca      180

tggtacgcag actccgtgaa gggcagattc accatctcca gagagaacgc caagaacaca      240

ctgtttcttc aaatgaacag cctgagagct gaggacacgg ctgtctatta ctgtgcgagc      300

ttgactacag ggtctgactc ctggggccag ggagtcctgg tcaccgtctc ctcaggcggt      360

ggcgggtccg gtgggggtgg ctccgggggc ggtggctccg acatccagat gacccagtct      420

ccatcttccc tgtctgcatc tgtaggggac agagtcacca tcacttgcag ggcaagtcag      480

gacattaggt attatttaaa ttggtatcag cagaaaccag gaaaagctcc taagctcctg      540

atctatgttg catccagttt gcaaagtggg gtcccatcaa ggttcagcgg cagtggatct      600

gggacagagt tcactctcac cgtcagcagc ctgcagcctg aagattttgc gacttattac      660

tgtctacagg tttatagtac ccctcggacg ttcggccaag ggaccaaggt ggaaatcaaa      720


<210>  8
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Thr Phe Asn 
            20                  25                  30          


Asn Tyr Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Arg Ile Ser Ser Ser Gly Asp Pro Thr Trp Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Leu Thr Thr Gly Ser Asp Ser Trp Gly Gln Gly Val 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Asp Ile Arg Tyr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Val 
    210                 215                 220                 


Tyr Ser Thr Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


<210>  9
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  9
gacatccaga tgacccagtc tccatcttcc ctgtctgcat ctgtagggga cagagtcacc       60

atcacttgca gggcaagtca ggacattagg tattatttaa attggtatca gcagaaacca      120

ggaaaagctc ctaagctcct gatctatagc gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagag ttcactctca ccgtcagcag cctgcagcct      240

gaagatgccg cgacttatta ctgtctacag gtttatagta cccctcggac gttcggccaa      300

gggaccaagg tggaaatcaa aggcggtggc gggtccggtg ggggtggctc cgggggcggt      360

ggctccgagg tgcagctggt gcagtctggg ggcggcttgg caaagcctgg ggggtccctg      420

agactctcct gcgcagcctc cgggttcagg ttcaccttca gcaactacta catggactgg      480

gtccgccagg ctccagggca ggggctggag tgggtcggcc gtattagtag tagtggtgat      540

cccacatggt acgcagactc cgtgaagggc agattcacca tctccagaga caacgccaag      600

aacacactgt ttcttcaaat gaacagcctg agagctgagg acacggctgt ctattactgt      660

gcgagcttga ctacagggtc tgactcctgg ggccagggag tcctggtcac cgtctcctca      720


<210>  10
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Tyr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Val Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln 
        115                 120                 125             


Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Arg Phe Thr Phe Ser Asn Tyr Tyr Met Asp Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Gly Arg Ile Ser 
                165                 170                 175     


Ser Ser Gly Asp Pro Thr Trp Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Leu Thr 
    210                 215                 220                 


Thr Gly Ser Asp Ser Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


<210>  11
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  11
gacatccaga tgacccagtc tccatcttcc ctgtctgcat ctgtagggga cagagtcacc       60

atcacttgca gggcaagtca ggacattagg tattatttaa attggtatca gcagaaacca      120

ggaaaagctc ctaagctcct gatctatagc gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagag ttcactctca ccgtcagcag cctgcagcct      240

gaagatgccg cgacttatta ctgtctacag gtttatagta cccctcggac gttcggccaa      300

gggaccaagg tggaaatcaa aggcggtggc gggtccggtg ggggtggctc cgggggcggt      360

ggctccgagg tgcagctggt gcagtctggg ggcggcttgg caaagcctgg ggggtccctg      420

agactctcct gcgcagcctc cgggttcagg ttcaccttca ataactacta catggactgg      480

gtccgccagg ctccagggca ggggctggag tgggtcggcc gtattagtag tagtggtgat      540

cacacatggt acgcagactc cgtgaagggc agattcacca tctccagaga gaacgccaag      600

aacacactgt ttcttcaaat gaacagcctg agagctgagg acacggctgt ctattactgt      660

gcgagcttga ctacagggtc tgactcctgg ggccagggag tcctggtcac cgtctcctca      720

tga                                                                    723


<210>  12
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Tyr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Val Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln 
        115                 120                 125             


Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Arg Phe Thr Phe Asn Asn Tyr Tyr Met Asp Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Gly Arg Ile Ser 
                165                 170                 175     


Ser Ser Gly Asp His Thr Trp Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Leu Thr 
    210                 215                 220                 


Thr Gly Ser Asp Ser Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


<210>  13
<211>  2142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  13
gacatccaga tgacccagtc tccatcttcc ctgtctgcat ctgtagggga cagagtcacc       60

atcacttgca gggcaagtca ggacattagg tattatttaa attggtatca gcagaaacca      120

ggaaaagctc ctaagctcct gatctatagc gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagag ttcactctca ccgtcagcag cctgcagcct      240

gaagatgccg cgacttatta ctgtctacag gtttatagta cccctcggac gttcggccaa      300

gggaccaagg tggaaatcaa aggcggtggc gggtccggtg ggggtggctc cgggggcggt      360

ggctccgagg tgcagctggt gcagtctggg ggcggcttgg caaagcctgg ggggtccctg      420

agactctcct gcgcagcctc cgggttcagg ttcaccttca gcaactacta catggactgg      480

gtccgccagg ctccagggca ggggctggag tgggtcggcc gtattagtag tagtggtgat      540

cccacatggt acgcagactc cgtgaagggc agattcacca tctccagaga caacgccaag      600

aacacactgt ttcttcaaat gaacagcctg agagctgagg acacggctgt ctattactgt      660

gcgagcttga ctacagggtc tgactcctgg ggccagggag tcctggtcac cgtctcctca      720

ggcggtggag ggtccggtgg agggggctct ggagggggcg gttcaggggg cggtggatcc      780

gggggaggtg gctccgaggt gcagctggtg gagtctgggg gcggcttggc aaagcctggg      840

gggtccctga gactctcctg cgcagcctcc gggttcaggt tcaccttcaa taactactac      900

atggactggg tccgccaggc tccagggcag gggctggagt gggtctcacg tattagtagt      960

agtggtgatc ccacatggta cgcagactcc gtgaagggca gattcaccat ctccagagag     1020

aacgccaaga acacactgtt tcttcaaatg aacagcctga gagctgagga cacggctgtc     1080

tattactgtg cgagcttgac tacagggtct gactcctggg gccagggagt cctggtcacc     1140

gtctcctcag ctagcaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc     1200

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg     1260

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta     1320

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc     1380

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa     1440

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc     1500

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     1560

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag     1620

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     1680

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1740

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1800

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1860

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1920

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1980

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     2040

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     2100

cactacacgc agaagagcct ctccctgtct ccgggtaaat ga                        2142


<210>  14
<211>  713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Tyr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Val Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln 
        115                 120                 125             


Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Arg Phe Thr Phe Ser Asn Tyr Tyr Met Asp Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Gly Arg Ile Ser 
                165                 170                 175     


Ser Ser Gly Asp Pro Thr Trp Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Leu Thr 
    210                 215                 220                 


Thr Gly Ser Asp Ser Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Ala Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Phe Arg Phe Thr Phe Asn Asn Tyr Tyr Met Asp Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Ser Arg Ile Ser Ser 
305                 310                 315                 320 


Ser Gly Asp Pro Thr Trp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                325                 330                 335     


Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Asn Ser 
            340                 345                 350         


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Leu Thr Thr 
        355                 360                 365             


Gly Ser Asp Ser Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser Ala 
    370                 375                 380                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
385                 390                 395                 400 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                405                 410                 415     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            420                 425                 430         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        435                 440                 445             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    450                 455                 460                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
465                 470                 475                 480 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                485                 490                 495     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            500                 505                 510         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        515                 520                 525             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    530                 535                 540                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
545                 550                 555                 560 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                565                 570                 575     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            580                 585                 590         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        595                 600                 605             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    610                 615                 620                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
625                 630                 635                 640 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                645                 650                 655     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            660                 665                 670         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        675                 680                 685             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    690                 695                 700                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710             


<210>  15
<211>  2115
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  15
gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc ctggggggtc cctgagactc       60

tcctgcgcag cctccgggtt caggttcacc ttcaataact actacatgga ctgggtccgc      120

caggctccag ggcaggggct ggagtgggtc tcacgtatta gtagtagtgg tgatcccaca      180

tggtacgcag actccgtgaa gggcagattc accatctcca gagagaacgc caagaacaca      240

ctgtttcttc aaatgaacag cctgagagct gaggacacgg ctgtctatta ctgtgcgagc      300

ttgactacag ggtctgactc ctggggccag ggagtcctgg tcaccgtctc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaatccggc gggggtggat ccggtggagg gggctccggc     1380

ggtggcgggt ccgacatcca gatgacccag tctccatctt ccctgtctgc atctgtaggg     1440

gacagagtca ccatcacttg cagggcaagt caggacatta ggtattattt aaattggtat     1500

cagcagaaac caggaaaagc tcctaagctc ctgatctata gcgcatccag tttgcaaagt     1560

ggggtcccat caaggttcag cggcagtgga tctgggacag agttcactct caccgtcagc     1620

agcctgcagc ctgaagatgc cgcgacttat tactgtctac aggtttatag tacccctcgg     1680

acgttcggcc aagggaccaa ggtggaaatc aaaggcggtg gcgggtccgg tgggggtggc     1740

tccgggggcg gtggctccga ggtgcagctg gtgcagtctg ggggcggctt ggcaaagcct     1800

ggggggtccc tgagactctc ctgcgcagcc tccgggttca ggttcacctt cagcaactac     1860

tacatggact gggtccgcca ggctccaggg caggggctgg agtgggtcgg ccgtattagt     1920

agtagtggtg atcccacatg gtacgcagac tccgtgaagg gcagattcac catctccaga     1980

gacaacgcca agaacacact gtttcttcaa atgaacagcc tgagagctga ggacacggct     2040

gtctattact gtgcgagctt gactacaggg tctgactcct ggggccaggg agtcctggtc     2100

accgtctcct catga                                                      2115


<210>  16
<211>  704
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Thr Phe Asn 
            20                  25                  30          


Asn Tyr Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Arg Ile Ser Ser Ser Gly Asp Pro Thr Trp Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Leu Thr Thr Gly Ser Asp Ser Trp Gly Gln Gly Val 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
465                 470                 475                 480 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Tyr Tyr 
                485                 490                 495     


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            500                 505                 510         


Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
        515                 520                 525             


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
    530                 535                 540                 


Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Val Tyr Ser Thr Pro Arg 
545                 550                 555                 560 


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
                565                 570                 575     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln 
            580                 585                 590         


Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        595                 600                 605             


Ala Ala Ser Gly Phe Arg Phe Thr Phe Ser Asn Tyr Tyr Met Asp Trp 
    610                 615                 620                 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Gly Arg Ile Ser 
625                 630                 635                 640 


Ser Ser Gly Asp Pro Thr Trp Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                645                 650                 655     


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Asn 
            660                 665                 670         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Leu Thr 
        675                 680                 685             


Thr Gly Ser Asp Ser Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser 
    690                 695                 700                 


<210>  17
<211>  2142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  17
gacatccaga tgacccagtc tccatcttcc ctgtctgcat ctgtagggga cagagtcacc       60

atcacttgca gggcaagtca ggacattagg tattatttaa attggtatca gcagaaacca      120

ggaaaagctc ctaagctcct gatctatagc gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagag ttcactctca ccgtcagcag cctgcagcct      240

gaagatgccg cgacttatta ctgtctacag gtttatagta cccctcggac gttcggccaa      300

gggaccaagg tggaaatcaa aggcggtggc gggtccggtg ggggtggctc cgggggcggt      360

ggctccgagg tgcagctggt gcagtctggg ggcggcttgg caaagcctgg ggggtccctg      420

agactctcct gcgcagcctc cgggttcagg ttcaccttca ataactacta catggactgg      480

gtccgccagg ctccagggca ggggctggag tgggtcggcc gtattagtag tagtggtgat      540

cacacatggt acgcagactc cgtgaagggc agattcacca tctccagaga gaacgccaag      600

aacacactgt ttcttcaaat gaacagcctg agagctgagg acacggctgt ctattactgt      660

gcgagcttga ctacagggtc tgactcctgg ggccagggag tcctggtcac cgtctcctca      720

ggcggtggag ggtccggtgg agggggctct ggagggggcg gttcaggggg cggtggatcc      780

gggggaggtg gctccgaggt gcagctggtg gagtctgggg gcggcttggc aaagcctggg      840

gggtccctga gactctcctg cgcagcctcc gggttcaggt tcaccttcaa taactactac      900

atggactggg tccgccaggc tccagggcag gggctggagt gggtctcacg tattagtagt      960

agtggtgatc ccacatggta cgcagactcc gtgaagggca gattcaccat ctccagagag     1020

aacgccaaga acacactgtt tcttcaaatg aacagcctga gagctgagga cacggctgtc     1080

tattactgtg cgagcttgac tacagggtct gactcctggg gccagggagt cctggtcacc     1140

gtctcctcag ctagcaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc     1200

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg     1260

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta     1320

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc     1380

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa     1440

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc     1500

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc     1560

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag     1620

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     1680

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1740

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1800

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1860

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1920

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1980

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     2040

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     2100

cactacacgc agaagagcct ctccctgtct ccgggtaaat ga                        2142


<210>  18
<211>  713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Tyr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Val Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln 
        115                 120                 125             


Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Arg Phe Thr Phe Asn Asn Tyr Tyr Met Asp Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Gly Arg Ile Ser 
                165                 170                 175     


Ser Ser Gly Asp His Thr Trp Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Leu Thr 
    210                 215                 220                 


Thr Gly Ser Asp Ser Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Ala Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Phe Arg Phe Thr Phe Asn Asn Tyr Tyr Met Asp Trp Val 
    290                 295                 300                 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Ser Arg Ile Ser Ser 
305                 310                 315                 320 


Ser Gly Asp Pro Thr Trp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                325                 330                 335     


Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Asn Ser 
            340                 345                 350         


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Leu Thr Thr 
        355                 360                 365             


Gly Ser Asp Ser Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser Ala 
    370                 375                 380                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
385                 390                 395                 400 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                405                 410                 415     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            420                 425                 430         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        435                 440                 445             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    450                 455                 460                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
465                 470                 475                 480 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                485                 490                 495     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            500                 505                 510         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        515                 520                 525             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    530                 535                 540                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
545                 550                 555                 560 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                565                 570                 575     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            580                 585                 590         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        595                 600                 605             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    610                 615                 620                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
625                 630                 635                 640 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                645                 650                 655     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            660                 665                 670         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        675                 680                 685             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    690                 695                 700                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710             


<210>  19
<211>  2115
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  19
gaggtgcagc tggtggagtc tgggggcggc ttggcaaagc ctggggggtc cctgagactc       60

tcctgcgcag cctccgggtt caggttcacc ttcaataact actacatgga ctgggtccgc      120

caggctccag ggcaggggct ggagtgggtc tcacgtatta gtagtagtgg tgatcccaca      180

tggtacgcag actccgtgaa gggcagattc accatctcca gagagaacgc caagaacaca      240

ctgtttcttc aaatgaacag cctgagagct gaggacacgg ctgtctatta ctgtgcgagc      300

ttgactacag ggtctgactc ctggggccag ggagtcctgg tcaccgtctc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaatccggc gggggtggat ccggtggagg gggctccggc     1380

ggtggcgggt ccgacatcca gatgacccag tctccatctt ccctgtctgc atctgtaggg     1440

gacagagtca ccatcacttg cagggcaagt caggacatta ggtattattt aaattggtat     1500

cagcagaaac caggaaaagc tcctaagctc ctgatctata gcgcatccag tttgcaaagt     1560

ggggtcccat caaggttcag cggcagtgga tctgggacag agttcactct caccgtcagc     1620

agcctgcagc ctgaagatgc cgcgacttat tactgtctac aggtttatag tacccctcgg     1680

acgttcggcc aagggaccaa ggtggaaatc aaaggcggtg gcgggtccgg tgggggtggc     1740

tccgggggcg gtggctccga ggtgcagctg gtgcagtctg ggggcggctt ggcaaagcct     1800

ggggggtccc tgagactctc ctgcgcagcc tccgggttca ggttcacctt caataactac     1860

tacatggact gggtccgcca ggctccaggg caggggctgg agtgggtcgg ccgtattagt     1920

agtagtggtg atcacacatg gtacgcagac tccgtgaagg gcagattcac catctccaga     1980

gagaacgcca agaacacact gtttcttcaa atgaacagcc tgagagctga ggacacggct     2040

gtctattact gtgcgagctt gactacaggg tctgactcct ggggccaggg agtcctggtc     2100

accgtctcct catga                                                      2115


<210>  20
<211>  704
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Thr Phe Asn 
            20                  25                  30          


Asn Tyr Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Arg Ile Ser Ser Ser Gly Asp Pro Thr Trp Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Leu Thr Thr Gly Ser Asp Ser Trp Gly Gln Gly Val 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
465                 470                 475                 480 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Tyr Tyr 
                485                 490                 495     


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            500                 505                 510         


Tyr Ser Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
        515                 520                 525             


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
    530                 535                 540                 


Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Val Tyr Ser Thr Pro Arg 
545                 550                 555                 560 


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
                565                 570                 575     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln 
            580                 585                 590         


Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        595                 600                 605             


Ala Ala Ser Gly Phe Arg Phe Thr Phe Asn Asn Tyr Tyr Met Asp Trp 
    610                 615                 620                 


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val Gly Arg Ile Ser 
625                 630                 635                 640 


Ser Ser Gly Asp His Thr Trp Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                645                 650                 655     


Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Asn 
            660                 665                 670         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Leu Thr 
        675                 680                 685             


Thr Gly Ser Asp Ser Trp Gly Gln Gly Val Leu Val Thr Val Ser Ser 
    690                 695                 700                 


<210>  21
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide 

<400>  21

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val Leu Ser 
            


<210>  22
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide 

<400>  22

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys 
            20          


<210>  23
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide P5E8-VL01F 

<400>  23
cgctggtggt gccgttctat agccatagtg acatccagat gacc                        44


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide P5E8-VL01R 

<400>  24
gtggtcgact ttgatttcca c                                                 21


<210>  25
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide P5E8-VH01F 

<400>  25
cgctggtggt gccgttctat agccatagtg aggtgcagct ggtggag                     47


<210>  26
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide P5E8-VH01R 

<400>  26
gtggtcgact gaggagacgg tgac                                              24


<210>  27
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide P5E8-Leader01

<400>  27
ggcatatgaa aaaactgctg ttcgcgattc cgctggtggt gccgttctat ag               52


<210>  28
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_E6Q 

<400>  28
gaggtgcagc tggtgcagtc tgggggcggc ttg                                    33


<210>  29
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_L11SDG 

<400>  29
gagtctgggg gcggcrrcgc aaagcctggg ggg                                    33


<210>  30
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_A12VK_K13QER 

<400>  30
gtctgggggc ggcttgrhgm agcctggggg gtccctg                                37


<210>  31
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_N32S 

<400>  31
gttcaggttc accttcagca actactacat ggac                                   34


<210>  32
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_D35bHSN 

<400>  32
caataactac tacatgmrct gggtccgcca ggctc                                  35


<210>  33
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_Q43KR 

<400>  33
cgccaggctc cagggarggg gctggagtgg gtc                                    33


<210>  34
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_S49GA 

<400>  34
gggctggagt gggtcgsccg tattagtagt agtg                                   34


<210>  35
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_I51M 

<400>  35
gagtgggtct cacgtatgag tagtagtggt gatc                                   34


<210>  36
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_Q37A 

<400>  36
ggtattattt aaattggtat gcccagaaac caggaaaag                              39


<210>  37
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_D55GS 

<400>  37
gtattagtag tagtggtrgc cccacatggt acgcag                                 36


<210>  38
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_P56STD 

<400>  38
gtagtagtgg tgatrvcaca tggtacgcag ac                                     32


<210>  39
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_W58YN 

<400>  39
gtggtgatcc cacawactac gcagactccg tg                                     32


<210>  40
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_E72DN 

<400>  40
gattcaccat ctccagarac aacgccaaga acacac                                 36


<210>  41
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_A74S 

<400>  41
catctccaga gagaacagca agaacacact gtttc                                  35


<210>  42
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_F79YSV 

<400>  42
gccaagaaca cactgkhcct tcaaatgaac agc                                    33


<210>  43
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_Q81E 

<400>  43
gaacacactg tttcttgaaa tgaacagcct gagag                                  35


<210>  44
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_A84G 

<400>  44
caaatgaaca gcctgagagg cgaggacacg gctgtc                                 36


<210>  45
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_V89AGT 

<400>  45
gagctgagga cacggctrsc tattactgtg cg                                     32


<210>  46
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_S94RK 

<400>  46
gtctattact gtgcgargtt gactacaggg tctg                                   34


<210>  47
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_V107T 

<400>  47
ctcctggggc cagggaaccc tggtcaccgt ctcc                                   34


<210>  48
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_L108AGS 

<400>  48
ctggggccag ggagtckscg tcaccgtctc ctcag                                  35


<210>  49
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_T110VS 

<400>  49
cagggagtcc tggtckycgt ctcctcagtc gac                                    33


<210>  50
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_L11G 

<400>  50
cagtctccat cttccggctc tgcatctgta ggg                                    33


<210>  51
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_V15AGS 

<400>  51
ccctgtctgc atctrscggg gacagagtca cc                                     32


<210>  52
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_V19L 

<400>  52
ctgtagggga cagactgacc atcacttgca gg                                     32


<210>  53
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_I21L 

<400>  53
ggggacagag tcaccctgac ttgcagggca ag                                     32


<210>  54
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_T22S 

<400>  54
gacagagtca ccatcagctg cagggcaagt cag                                    33


<210>  55
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_D28SG 

<400>  55
gcagggcaag tcagrgcatt aggtattatt taaattg                                37


<210>  56
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_R30SL 

<400>  56
gcaagtcagg acattmkcta ttatttaaat tgg                                    33


<210>  57
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_K39A 

<400>  57
aattggtatc agcaggcccc aggaaaagct cc                                     32


<210>  58
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_K45ER 

<400>  58
ccaggaaaag ctcctsrcct cctgatctat gttg                                   34


<210>  59
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_V50n 


<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  n is a, c, g, or t

<400>  59
ctaagctcct gatctatnnk gcatccagtt tgcaaag                                37


<210>  60
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_L54R 

<400>  60
ctatgttgca tccagtcgcc aaagtggggt ccc                                    33


<210>  61
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_V58S 

<400>  61
cagtttgcaa agtgggtccc catcaaggtt cagc                                   34


<210>  62
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_E70D 

<400>  62
cagtggatct gggacagact tcactctcac cgtc                                   34


<210>  63
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_V75I 

<400>  63
gagttcactc tcaccatcag cagcctgcag cc                                     32


<210>  64
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_P80AG 

<400>  64
cagcagcctg cagrgcgaag attttgcgac                                        30


<210>  65
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_F83AGST 

<400>  65
ctgcagcctg aagatrscgc gacttattac tg                                     32


<210>  66
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_T85D 

<400>  66
cctgaagatt ttgcggacta ttactgtcta cag                                    33


<210>  67
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_L89AQ 

<400>  67
gcgacttatt actgtsmrca ggtttatagt acc                                    33


<210>  68
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_R96LY 

<400>  68
gtttatagta cccctmwaac gttcggccaa ggg                                    33


<210>  69
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_F98W 

<400>  69
gtacccctcg gacgtggggc caagggacca ag                                     32


<210>  70
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_I106AGS 

<400>  70
gggaccaagg tggaakscaa aggcggtggc ggg                                    33


<210>  71
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_L45C 

<400>  71
gctccagggc aggggtgcga gtgggtctca cg                                     32


<210>  72
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_F98C 

<400>  72
gtacccctcg gacgtgcggc caagggacca ag                                     32


<210>  73
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_D101C 

<400>  73
cttgactaca gggtcttgct cctggggcca gggag                                  35


<210>  74
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_L46C 

<400>  74
ggaaaagctc ctaagtgcct gatctatgtt gc                                     32


<210>  75
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_S102C 

<400>  75
gactacaggg tctgactgct ggggccaggg agtc                                   34


<210>  76
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_L46C 

<400>  76
ggaaaagctc ctaagtgcct gatctatgtt gc                                     32


<210>  77
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VH_G44C 

<400>  77
caggctccag ggcagtgcct ggagtgggtc tcac                                   34


<210>  78
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide VL_Q100C 

<400>  78
cctcggacgt tcggctgcgg gaccaaggtg gaaatc                                 36


<210>  79
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide 078F3

<400>  79
gttgctacgc gtggcggtgg atccggggga ggtggctccg aggtgcagct ggtggagtct       60

gg                                                                      62


<210>  80
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide 078-R3

<400>  80
gttaacagat cttcatttac ccggagacag ggagagg                                37


<210>  81
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide 078-F1

<400>  81
gttgctacgc gtgtcctgtc cgacatccag atgacccagt ctc                         43


<210>  82
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide 078-R4

<400>  82
tcccccggat ccaccgcccc ctgaaccgcc ccctccagag ccccctccac cggaccctcc       60

accgcctgag gagacggtga ccag                                              84


<210>  83
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide C-23VL-F 

<400>  83
agagagggat ccggtggagg gggctccggc ggtggcgggt ccgacatcca gatgacccag       60

tc                                                                      62


<210>  84
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide C-23VH-R 

<400>  84
agagagagat cttcatgagg agacggtgac caggac                                 36


<210>  85
<211>  122
<212>  PRT
<213>  Non-Human Primate

<400>  85

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Val Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Val Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Arg Ile Ser Gly Ser Gly Gly Ala Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ile Ile Ser Gln Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Asn Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Trp Ala Gln Ile Ala Gly Thr Thr Leu Gly Phe Trp 
            100                 105                 110         


Gly Gln Gly Val Leu Val Thr Val Ser Ser 
        115                 120         


<210>  86
<211>  6
<212>  PRT
<213>  Non-Human Primate

<400>  86

Ser Ser Asn Trp Trp Thr 
1               5       


<210>  87
<211>  17
<212>  PRT
<213>  Non-Human Primate

<400>  87

Arg Ile Ser Gly Ser Gly Gly Ala Thr Asn Tyr Asn Pro Ser Leu Lys 
1               5                   10                  15      


Ser 
    


<210>  88
<211>  12
<212>  PRT
<213>  Non-Human Primate

<400>  88

Asp Trp Ala Gln Ile Ala Gly Thr Thr Leu Gly Phe 
1               5                   10          


<210>  89
<211>  118
<212>  PRT
<213>  Non-Human Primate

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Thr Phe Asn 
            20                  25                  30          


Asn Tyr Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Arg Ile Ser Ser Ser Gly Asp Pro Thr Trp Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Leu Thr Thr Gly Ser Asp Ser Trp Gly Gln Gly Val 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  90
<211>  7
<212>  PRT
<213>  Non-Human Primate

<400>  90

Phe Asn Asn Tyr Tyr Met Asp 
1               5           


<210>  91
<211>  17
<212>  PRT
<213>  Non-Human Primate

<400>  91

Arg Ile Ser Ser Ser Gly Asp Pro Thr Trp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  92
<211>  7
<212>  PRT
<213>  Non-Human Primate

<400>  92

Leu Thr Thr Gly Ser Asp Ser 
1               5           


<210>  93
<211>  95
<212>  PRT
<213>  Non-Human Primate

<400>  93

Gln Ser Ala Pro Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Asp Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ala Lys Arg Ala Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Tyr Cys Cys Ser Tyr Thr Thr 
65                  70                  75                  80  


Ser Ser Thr Leu Leu Phe Gly Arg Gly Thr Arg Leu Thr Val Leu 
                85                  90                  95  


<210>  94
<211>  14
<212>  PRT
<213>  Non-Human Primate

<400>  94

Thr Gly Thr Ser Asp Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  95
<211>  7
<212>  PRT
<213>  Non-Human Primate

<400>  95

Asp Val Ala Lys Arg Ala Ser 
1               5           


<210>  96
<211>  10
<212>  PRT
<213>  Non-Human Primate

<400>  96

Cys Ser Tyr Thr Thr Ser Ser Thr Leu Leu 
1               5                   10  


<210>  97
<211>  107
<212>  PRT
<213>  Non-Human Primate

<400>  97

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Tyr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Val Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  98
<211>  11
<212>  PRT
<213>  Non-Human Primate

<400>  98

Arg Ala Ser Gln Asp Ile Arg Tyr Tyr Leu Asn 
1               5                   10      


<210>  99
<211>  10
<212>  PRT
<213>  Non-Human Primate

<400>  99

Val Ala Ser Ser Leu Gln Ser Pro Arg Thr 
1               5                   10  


<210>  100
<211>  9
<212>  PRT
<213>  Non-Human Primate

<400>  100

Leu Gln Val Tyr Ser Thr Pro Arg Thr 
1               5                   


<210>  101
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic gly-ser connecting peptide 

<400>  101

Gly Gly Gly Gly Ser 
1               5   


<210>  102
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic gly-ser connecting peptide 

<400>  102

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  103
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic gly-ser connecting peptide 

<400>  103

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  104
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic gly-ser connecting peptide 

<400>  104

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  105
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic gly-ser connecting peptide 

<400>  105

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  106
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic gly-ser connecting peptide 

<400>  106

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  107
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker peptide 

<400>  107

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ala Ser 
            20                  25  


